ID   HEM1_AGABI     STANDARD;      PRT;   621 AA.
AC   Q92403;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   5-aminolevulinate synthase, mitochondrial precursor (EC 2.3.1.37) (5-
DE   aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-
DE   ALA synthetase).
GN   Name=hem1;
OS   Agaricus bisporus (Common mushroom).
OC   Eukaryota; Fungi; Basidiomycota; Hymenomycetes; Homobasidiomycetes;
OC   Agaricales; Agaricaceae; Agaricus.
OX   NCBI_TaxID=5341;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=D649;
RA   Yague E., Mehak-Zunic M., Wood D.A., Thurston C.F.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Succinyl-CoA + glycine = 5-aminolevulinate +
CC       CoA + CO(2).
CC   -!- COFACTOR: Pyridoxal phosphate.
CC   -!- PATHWAY: Heme biosynthesis; first (rate-limiting) step.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrial matrix.
CC   -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC       aminotransferase family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
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CC   --------------------------------------------------------------------------
DR   EMBL; Z50096; CAA90424.1; -.
DR   HSSP; P07912; 1FC4.
DR   InterPro; IPR010961; 5aminolev_synth.
DR   InterPro; IPR003408; Ala_synthase.
DR   InterPro; IPR004839; Aminotrans_I/II.
DR   InterPro; IPR001917; Aminotrans_II.
DR   Pfam; PF02490; ALA_synthase; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   TIGRFAMs; TIGR01821; 5aminolev_synth; 1.
DR   PROSITE; PS00599; AA_TRANSFER_CLASS_2; 1.
KW   Acyltransferase; Heme biosynthesis; Mitochondrion;
KW   Pyridoxal phosphate; Transferase; Transit peptide.
FT   TRANSIT       1      ?       Mitochondrion.
FT   CHAIN         ?    621       5-aminolevulinate synthase.
FT   BINDING     362    362       Pyridoxal phosphate (covalent)
FT                                (Probable).
SQ   SEQUENCE   621 AA;  67426 MW;  A335C3268FAE1AA3 CRC64;
     MSHHGPRLST RSQQIVAGYA SVAANFDVEK LHREQGVNIP TSGASINQCP HAAAARAAAR
     MADDLASAAR AKKSLDAKGS LAGRPVHHKA ATESTKAKHT GFDYEAFYKG ELAKKHQDKS
     YRYFNNINRL ARKFPVAHTA NPRDEVEVWC SNDYLGMGNN PVVLETMHRT LDKYGHGAGG
     TRNIAGNGAM HLGLERELRL HRKEAALVFS SCYVANDATL STLGTKLPGC VIFSDTMNHA
     SMIQGMRHST PKRVIFKHND LEDLETKLQQ YPKETPKIIA FESVYSMCGS IGPVKEICDL
     AEQYGAITFL DEVHAVGLYG PRGAGVAEHL DYDAHLAAGS SPDPIPGSVM DRIDIITGTL
     GKSYGAVGGY IAGSEEFVDM IRSYAPGFIF TTSLPPATVA GARASIVYQS EYLGDRQLKQ
     INVREVKRRL AELDIPVVPG SSHIVPVLVG DAALARAASD KLLSEHDIYV QAINYPTVAR
     GEERLRITVT PRHTMEQMEG LIRSLNQVFE ELNINRLSDW KLAGGRAGVG IPGAADDVQP
     IWTDEQIGLL NGTAPRSLRN AEKSVVDMRA VTIARSRFDV LLGPVYGELQ PTEDFDTPAV
     GATFKAPLVD REVAHDITVS A
//