ID   CBF5_EMENI     STANDARD;      PRT;   481 AA.
AC   O43100;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Centromere/microtubule binding protein CBF5 (Centromere-binding factor
DE   5) (Small nucleolar RNP protein CBF5) (H/ACA snoRNP protein CBF5).
GN   Name=cbf5;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Jiang W., Clifford J., Koltin Y.;
RT   "A highly conserved nucleolar protein Cbf5p may be involved in the
RT   centromere DNA-binding activity of protein complex CBF3.";
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds in vitro to centromeres and microtubules. It is a
CC       centromere DNA-CBF3-binding factor and is involved in mitotic
CC       chromosome segregation. Essential for cell growth (By similarity).
CC   -!- FUNCTION: Involved in ribosome biogenesis; more specifically in
CC       18S rRNA pseudouridylation and in cleavage of pre-rRNA. May
CC       function as a pseudouridine synthase (By similarity).
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein
CC       particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear; nucleolar (By similarity).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase truB family.
CC   -!- SIMILARITY: Contains 1 PUA domain.
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DR   EMBL; U59148; AAB94296.1; -.
DR   HSSP; P09171; 1K8W.
DR   InterPro; IPR004802; Cbf5_synth.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR002501; TruB__synth_N.
DR   InterPro; IPR004521; Unchar_dom_2.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SMART; SM00359; PUA; 1.
DR   TIGRFAMs; TIGR00425; CBF5; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
KW   Centromere; DNA-binding; Microtubule; Nuclear protein; Repeat;
KW   Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   DOMAIN      268    343       PUA.
SQ   SEQUENCE   481 AA;  54204 MW;  A671BB6C57CE9590 CRC64;
     MAKEVDYTIK PEATASNINT EDWPLLLKNY DKLMVRTGHF TPIPAGSSPL KRDLKSYINS
     GVINLDKPSN PSSHEVVAWM KRILRAEKTG HSGTLDPKVT GCLIVCIDRA TRLVKSQQGA
     GKEYVCVIRL HDKIPGGEAQ FKRALETLTG ALFQRPPLIS AVKRQLRIRT IHESKLYEFD
     NERHLGVFWV SCEAGTYIRT LCVHLGLLLG VGAHMQELRR VRSGAMSENE GMVTLHDVLD
     AQWLYDNQRD ESYLRKVIKP LESLLTTYKR IVVKDSAVNA VCYGAKLMIP GLLRFEAGIE
     LGEEVVLMTT KGEAIAIGIA QMSTVELSTC DHGVVAKVKR CIMERDLYPR RWGLGPVALE
     KKKLKSSGKL DKYGRANEAT PAKWKSEYKD YSAPDGDSSQ QAVDVVAKEE ASPKEEPSLE
     ANESKMDIDD AQDDEDKKKR KRHEGETPEE RAERKRKKKE KKEKKERRKS KQEKDDSDDS
     D
//