ID   CBF5_ASPFU     STANDARD;      PRT;   487 AA.
AC   O43102;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Centromere/microtubule binding protein CBF5 (Centromere-binding factor
DE   5) (Small nucleolar RNP protein CBF5) (H/ACA snoRNP protein CBF5).
GN   Name=cbf5;
OS   Aspergillus fumigatus (Sartorya fumigata).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=5085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Jiang W., Clifford J., Koltin Y.;
RT   "A highly conserved nucleolar protein Cbf5p may be involved in the
RT   centromere DNA-binding activity of protein complex CBF3.";
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds in vitro to centromeres and microtubules. It is a
CC       centromere DNA-CBF3-binding factor and is involved in mitotic
CC       chromosome segregation. Essential for cell growth (By similarity).
CC   -!- FUNCTION: Involved in ribosome biogenesis; more specifically in
CC       18S rRNA pseudouridylation and in cleavage of pre-rRNA. May
CC       function as a pseudouridine synthase (By similarity).
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein
CC       particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nuclear; nucleolar (By similarity).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase truB family.
CC   -!- SIMILARITY: Contains 1 PUA domain.
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DR   EMBL; U59150; AAB94298.1; -.
DR   InterPro; IPR004802; Cbf5_synth.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR002501; TruB__synth_N.
DR   InterPro; IPR004521; Unchar_dom_2.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   TIGRFAMs; TIGR00425; CBF5; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
KW   Centromere; DNA-binding; Microtubule; Nuclear protein; Repeat;
KW   Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   DOMAIN      273    348       PUA.
SQ   SEQUENCE   487 AA;  54726 MW;  3B38D74A4EF2FFD0 CRC64;
     MAVSVTKEEM DYTIKPEAGA SNISTEDWPL LLKNYDKLMV RTGHFTPIPA GCSPLKRDLK
     SYISSGVINL DKPSNPSSHE VVAWMKRILR AEKTGHSGTL DPKVTGCLIV CIDRATRLVK
     SQQGAGKEYV CVIRLHDKIP GGEAQFKRAL ETLTGALFQR PPLISAVKRQ LRIRTIHESK
     LYEFDNDRHL GVFWVSCEAG TYIRTLCVHL GLLLGVGAHM QELRRVRSGA MDENNGLVTL
     HDVLDAQWMY DNQRDESYLR RVIQPLESLL TTYKRIVVKD SAVNAVCYGA KLMIPGLLRF
     EAGIEVNEEV VLMTTKGEAI AIGIAQMSTV ELSTCDHGVV AKVKRCIMER DLYPRRWGLG
     PVALEKKKLK SAGKLDKYGR ANEDTPAKWK TEYKDYSAPE EASAHAASES TAKEDVAAAL
     TTEQDEAPSS PQSKMDVDET KEEKKRKRHE GETAEERAER KRKKKEKKEK KERRKSKQEK
     EDSDDSD
//