ID   AMDS_EMENI     STANDARD;      PRT;   548 AA.
AC   P08158;
DT   01-AUG-1988 (Rel. 08, Created)
DT   01-AUG-1988 (Rel. 08, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Acetamidase (EC 3.5.1.4).
GN   Name=amdS;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=87248110; PubMed=3036667; DOI=10.1016/0378-1119(87)90093-X;
RA   Corrick C.M., Twomey A.P., Hynes M.J.;
RT   "The nucleotide sequence of the amdS gene of Aspergillus nidulans and
RT   the molecular characterization of 5' mutations.";
RL   Gene 53:63-71(1987).
CC   -!- FUNCTION: Allows acetamide to be used as a sole carbon or nitrogen
CC       source.
CC   -!- CATALYTIC ACTIVITY: A monocarboxylic acid amide + H(2)O = a
CC       monocarboxylate + NH(3).
CC   -!- INDUCTION: Acetate induction mediated by facB regulatory gene and
CC       probably by amdA regulatory gene. Omega amino acid induction is
CC       dependent on amdR regulatory gene.
CC   -!- SIMILARITY: Belongs to the amidase family.
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DR   EMBL; M16371; AAA33295.1; -.
DR   PIR; A26511; A26511.
DR   HSSP; P97612; 1MT5.
DR   InterPro; IPR000120; Amidase.
DR   Pfam; PF01425; Amidase; 1.
DR   PROSITE; PS00571; AMIDASES; 1.
KW   Hydrolase.
FT   ACT_SITE    129    129       Charge relay system (By similarity).
FT   ACT_SITE    204    204       Charge relay system (By similarity).
FT   ACT_SITE    228    228       Acyl-ester intermediate (By similarity).
SQ   SEQUENCE   548 AA;  60229 MW;  1EC6368CB867C630 CRC64;
     MPQSWEELAA DKRARLAKTI PDEWKVQTLP AEDSVIDFPK KSGILSEAEL KITEASAADL
     VSKLAAGELT SVEVTLAFCK RAAIAQQLTN CAHEFFPDAA LAQARELDEY YAKHKRPVGP
     LHGLPISLKD QLRVKGYETS MGYISWLNKY DEGDSVLTTM LRKAGAVFYV KTSVPQTLMV
     CETVNNIIGR TVNPRNKNWS CGGSSGGEGA IVGIRGGVIG VGTDIGGSIR VPAAFNFLYG
     LRPSHGRLPY AKMANSMEGQ ETVHSVVGPI THSVEDLRLF TKSVLGQEPW KYDSKVIPMP
     WRQSESDIIA SKIKNGGLNI GYYNFDGNVL PHPPILRGVE TTVAALAKAG HTVTPWTPYK
     HDFGHDLISH IYAADGSADV MRDISASGEP AIPNIKDLLN PNIKAVNMNE LWDTHLQKWN
     YQMEYLEKWR EAEEKAGKEL DAIIAPITPT AAVRHDQFRY YGYASVINLL DFTSVVVPVT
     FADKNIDKKN ESFKAVSELD ALVQEEYDPE AYHGAPVAVQ VIGRRLSEER TLAIAEEVGK
     LLGNVVTP
//