ID   ADH1_EMENI     STANDARD;      PRT;   349 AA.
AC   P08843;
DT   01-NOV-1988 (Rel. 09, Created)
DT   01-NOV-1988 (Rel. 09, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Alcohol dehydrogenase I (EC 1.1.1.1) (ADH I).
GN   Name=alcA;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=87248079; PubMed=3297923; DOI=10.1016/0378-1119(87)90309-X;
RA   Gwynne D.I., Buxton F.P., Sibley S., Davies R.W., Lockington R.A.,
RA   Scazzocchio C., Sealy-Lewis H.M.;
RT   "Comparison of the cis-acting control regions of two coordinately
RT   controlled genes involved in ethanol utilization in Aspergillus
RT   nidulans.";
RL   Gene 51:205-216(1987).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; M16196; AAA33291.1; -.
DR   PIR; A29054; A29054.
DR   HSSP; P39462; 1JVB.
DR   InterPro; IPR002328; ADH_zinc.
DR   InterPro; IPR002085; Adh_zn_family.
DR   InterPro; IPR011032; GroES_like.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
KW   Metal-binding; Multigene family; NAD; Oxidoreductase; Zinc.
FT   METAL        44     44       Zinc 1 (catalytic).
FT   METAL        67     67       Zinc 1 (catalytic).
FT   METAL        98     98       Zinc 2.
FT   METAL       101    101       Zinc 2.
FT   METAL       104    104       Zinc 2.
FT   METAL       112    112       Zinc 2.
FT   METAL       154    154       Zinc 1 (catalytic).
SQ   SEQUENCE   349 AA;  37181 MW;  23AB655D459E7B2C CRC64;
     MCIPTMQWAQ VAEKVGGPLV YKQIPVPKPG PDQILVKIRY SGVCHTDLHA MMGHWPIPVK
     MPLVGGHEGA GIVVAKGELV HEFEIGDQAG IKWLNGSCGE CEFCRQSDDP LCARAQLSGY
     TVDGTFQQYA LGKASHASKI PAGVPVDAAA PVLCAGITVY KGLKEAGVRP GQTVAIVGAG
     GGLGSLAQQY AKAMGIRVVA VDGGDEKRAM CESLGTETYV DFTKSKDLVA DVRHGRGCLG
     AHAVILLAVS EKPFQQATEY VRSRGTIVAI GLPPDAYLKA PVINTVVRMI TIKGSYVGNR
     QDGVEALDFF ARGLIKAPFK TAPLKDLPKI YELMEQGRIA GRYVLEMPE
//