ID   BRLA_EMENI     STANDARD;      PRT;   432 AA.
AC   P10069;
DT   01-MAR-1989 (Rel. 10, Created)
DT   01-MAR-1989 (Rel. 10, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Regulatory protein brlA (Bristle A protein).
GN   Name=brlA;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FGSC 4;
RX   MEDLINE=88282543; PubMed=3293800; DOI=10.1016/0092-8674(88)90198-5;
RA   Adams T.H., Boylan M.T., Timberlake W.E.;
RT   "brlA is necessary and sufficient to direct conidiophore development
RT   in Aspergillus nidulans.";
RL   Cell 54:353-362(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Kupfer D.M., Reece C.A., Clifton S.W., Roe B.A., Prade R.A.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE OF 1-37.
RC   STRAIN=FGSC 4;
RX   MEDLINE=93285114; PubMed=8508769;
RA   Prade R.A., Timberlake W.E.;
RT   "The Aspergillus nidulans brlA regulatory locus consists of
RT   overlapping transcription units that are individually required for
RT   conidiophore development.";
RL   EMBO J. 12:2439-2447(1993).
CC   -!- FUNCTION: Mediates the developmental switch from the
CC       indeterminate, apical growth pattern of vegetative cells to the
CC       budding growth pattern of conidiophores. Expression of brlA leads
CC       to activation of abaA, wetA and stuA cessation of vegetative
CC       growth, cellular vacuolization and spore formation. BrlA, abaA and
CC       wetA are pivotal regulators of conidiophore development and
CC       conidium maturation. They act individually and together to
CC       regulate their own expression and that of numerous other
CC       sporulation-specific genes.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- SIMILARITY: Contains 2 C2H2-type zinc fingers.
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DR   EMBL; M20631; AAA33300.1; -.
DR   EMBL; AC000133; AAB48671.1; -.
DR   EMBL; S62606; AAB27149.1; -.
DR   PIR; A28913; A28913.
DR   HSSP; P07248; 1ARD.
DR   TRANSFAC; T00069; -.
DR   InterPro; IPR007087; Znf_C2H2.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
KW   Conidiation; Developmental protein; DNA-binding; Metal-binding;
KW   Repeat; Zinc-finger.
FT   ZN_FING     320    344       C2H2-type 1.
FT   ZN_FING     350    375       C2H2-type 2.
SQ   SEQUENCE   432 AA;  47932 MW;  CA93E6A21CD33E25 CRC64;
     MRNQSSLSDR LTVEVDCSSL GSNECPSMTS SFSPLESPTP TPTSIYSQGS LESPGWHGAG
     SLPNNTYERT PGSASMRSAF RLAGMASTES LGLPYGSMEG QERMPMPDFL SGYDENIEQL
     WMPSEAPKSY DHVAQGLAYH QGMHQYPTMA RNTNNNYRHQ AAAYLPESTT NPCLSRSIFH
     QPERVPSSMS SSMSMNNMLP WMNLGDSIAP QTIAPSQVGP VTPPPSYTDF PTSLSAFKQH
     SPTTPIRSCS LGTGSGADTP LSRLSGGPCE YMDDFQPSPV YRDGFQRPHR VASRKMLRRQ
     TSKQNLMLEN LPQVIKQVQF KCKEPGCNGR FKRQEHLKRH MKSHSKEKPH VCWVPGCHRA
     FSRSDNLNAH YTKTHSKRGG RNRYVATLDE NSPDYDPEFR GQLTPDGRPI YGSKLDDPIP
     GAGDMSLDGW DE
//