ID   ACEA_EMENI     STANDARD;      PRT;   537 AA.
AC   P28298;
DT   01-DEC-1992 (Rel. 24, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   Isocitrate lyase (EC 4.1.3.1) (Isocitrase) (Isocitratase) (ICL).
GN   Name=acuD;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R153;
RX   MEDLINE=92136435; PubMed=1531185;
RA   Gainey L.D.S., Connerton I.F., Lewis E.H., Turner G., Ballance D.J.;
RT   "Characterization of the glyoxysomal isocitrate lyase genes of
RT   Aspergillus nidulans (acuD) and Neurospora crassa (acu-3).";
RL   Curr. Genet. 21:43-47(1992).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS), AND SEQUENCE REVISION TO 17
RP   AND 156.
RX   MEDLINE=20264302; PubMed=10801489; DOI=10.1016/S0969-2126(00)00117-9;
RA   Britton K.L., Langridge S.J., Baker P.J., Weeradechapon K.,
RA   Sedelnikova S.E., De Lucas J.R., Rice D.W., Turner G.;
RT   "The crystal structure and active site location of isocitrate lyase
RT   from the fungus aspergillus nidulans.";
RL   Structure 8:349-362(2000).
CC   -!- CATALYTIC ACTIVITY: Isocitrate = succinate + glyoxylate.
CC   -!- PATHWAY: Glyoxylate bypass; first step.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Glyoxysomal.
CC   -!- INDUCTION: By acetate.
CC   -!- SIMILARITY: Belongs to the isocitrate lyase family.
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DR   EMBL; X62696; CAA44572.1; ALT_SEQ.
DR   PDB; 1DQU; X-ray; A=1-536.
DR   InterPro; IPR006254; Isocit_lyase.
DR   InterPro; IPR000918; Isocit_lyase_ph.
DR   Pfam; PF00463; ICL; 1.
DR   ProDom; PD001857; Isocit_lyase_ph; 1.
DR   TIGRFAMs; TIGR01346; isocit_lyase; 1.
DR   PROSITE; PS00161; ISOCITRATE_LYASE; 1.
KW   3D-structure; Glyoxylate bypass; Glyoxysome; Lyase;
KW   Tricarboxylic acid cycle.
FT   ACT_SITE    205    205
SQ   SEQUENCE   537 AA;  60193 MW;  7109E853C351962D CRC64;
     MSYIEEEDQR YWDEVAAVKN WWKDSRWRYT KRPFTAEQIV AKRGNLKIEY PSNVQAKKLW
     GILERNFNKE ASFTYGCLDP TMVTQMAKYL DTVYVSGWQS SSTASSTDEP SPDLADYPMN
     TVPNKVNHLW MAQLFHDRKQ REERMTTPKD QRHKVANVDY LRPIIADADT GHGGLTAVMK
     LTKLFVERGA AGIHIEDQAP GTKKCGHMAG KVLVPISEHI NRLVAIRAQA DIMGTDLLAI
     ARTDSEAATL ITSTIDHRDH PFIIGSTNPD IQPLNDLMVM AEQAGKNGAE LQAIEDEWLA
     KAGLKLFNDA VVDAINNSPL PNKKAAIEKY LTQSKGKSNL EARAIAKEIA GTDIYFDWEA
     PRTREGYYRY QGGTQCAINR AVAYAPFADL IWMESKLPDY KQAKEFADGV HAVWPEQKLA
     YNLSPSFNWK KAMPRDEQET YIKRLGALGY AWQFITLAGL HTTALISDTF AKAYAKQGMR
     AYGELVQEPE MANGVDVVTH QKWSGANYVD NMLKMITGGV SSTAAMGKGV TEDQFKS
//