ID   GBA1_EMENI     STANDARD;      PRT;   352 AA.
AC   Q00743;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Guanine nucleotide-binding protein alpha subunit.
GN   Name=fadA;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND MUTAGENESIS OF GLY-41 AND GLY-202.
RC   STRAIN=FGSC 4;
RX   MEDLINE=97050824; PubMed=8895563;
RA   Yu J.H., Wieser J., Adams T.H.;
RT   "The Aspergillus FlbA RGS domain protein antagonizes G protein
RT   signaling to block proliferation and allow development.";
RL   EMBO J. 15:5184-5190(1996).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC       involved as modulators or transducers in various transmembrane
CC       signaling systems.
CC   -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
CC       gamma. The alpha chain contains the guanine nucleotide binding
CC       site.
CC   -!- SIMILARITY: Belongs to the G-alpha family. Subfamily 3 (G(q)).
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DR   EMBL; U49917; AAC49476.1; -.
DR   PIR; S71965; S71965.
DR   HSSP; P04896; 1CUL.
DR   InterPro; IPR002975; Fungi_GproteinA.
DR   InterPro; IPR001019; Gprotein_alpha.
DR   InterPro; IPR011025; Transducn_insert.
DR   Pfam; PF00503; G-alpha; 1.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR01241; GPROTEINAFNG.
DR   ProDom; PD000281; Gprotein_alpha; 1.
KW   GTP-binding; Lipoprotein; Myristate; Transducer.
FT   INIT_MET      0      0       By similarity.
FT   LIPID         1      1       N-myristoyl glycine (By similarity).
FT   NP_BIND      39     46       GTP (By similarity).
FT   NP_BIND     199    203       GTP (By similarity).
FT   NP_BIND     268    271       GTP (By similarity).
FT   MUTAGEN      41     41       G->R: Loss of intrinsic GTPase activity
FT                                leading to constitutive signaling.
FT   MUTAGEN     202    202       G->R: Reduced growth without impairing
FT                                sporulation.
SQ   SEQUENCE   352 AA;  40590 MW;  441E5B7331E0F43D CRC64;
     GCGMSTEDKE GKARNEEIEN QLKRDKMMQR NEIKMLLLGA GESGKSTILK QMKLIHEGGY
     SRDERESFKE IIYSNTVQSM RVILEAMESL ELPLEDARNE YHVQTVFMQP AQIEGDSLPS
     EVGNAIAALW QDAGVQECFK RSREYQLNDS AKYYFDSIER IAQSDYLPTD QDVLRSRVKT
     TGITETTFII GDLTYRMFDV GGQRSERKKW IHCFENVTTI LFLVAISEYD QLLFEDETVN
     RMQEALTLFD SICNSRWFVK TSIILFLNKI DRFKEKLPVS PMKNYFPDYE GGADYAAACD
     YILNRFVSLN QAEQKQIYTH FTCATDTTQI RFVMAAVNDI IIQENLRLCG LI
//