ID   FAAA_EMENI     STANDARD;      PRT;   431 AA.
AC   Q00770; O42828;
DT   29-MAR-2004 (Rel. 43, Created)
DT   29-MAR-2004 (Rel. 43, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Fumarylacetoacetase (EC 3.7.1.2) (Fumarylacetoacetate hydrolase)
DE   (Beta-diketonase) (FAA).
GN   Name=fahA; Synonyms=fah;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION.
RC   STRAIN=BIA1;
RX   MEDLINE=96016123; PubMed=7568087;
RA   Fernandez-Canon J.M., Penalva M.A.;
RT   "Fungal metabolic model for human type I hereditary tyrosinaemia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:9132-9136(1995).
RN   [2]
RP   SEQUENCE REVISION TO 67-68, AND PROBABLE FUNCTION.
RC   STRAIN=BIA1;
RX   MEDLINE=98079064; PubMed=9417084; DOI=10.1074/jbc.273.1.329;
RA   Fernandez-Canon J.M., Penalva M.A.;
RT   "Characterization of a fungal maleylacetoacetate isomerase gene and
RT   identification of its human homologue.";
RL   J. Biol. Chem. 273:329-337(1998).
CC   -!- FUNCTION: Use of phenylalanine and phenylacetate as a carbon
CC       source.
CC   -!- CATALYTIC ACTIVITY: 4-fumarylacetoacetate + H(2)O = acetoacetate +
CC       fumarate.
CC   -!- PATHWAY: Phenylalanine catabolism; sixth step.
CC   -!- PATHWAY: Tyrosine catabolism; fifth step.
CC   -!- INDUCTION: By phenylacetate (PhoAc), 2OH-PhoAc, 3OH-PhoAc, 4OH-
CC       PhoAc, phenylalanine, and tyrosine. Not induced by acetate or
CC       glutamate. Expression is partially repressed by glucose.
CC   -!- MISCELLANEOUS: Disruption of the fah gene results in phenylalanine
CC       toxicity, secretion of succinylacetone and the absence of growth.
CC       This is analogous to the genetic disease, type I hereditary
CC       tyrosinaemia in humans.
CC   -!- SIMILARITY: Belongs to the FAH family.
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DR   EMBL; L41670; AAA85778.1; -.
DR   EMBL; AJ001836; CAA05043.1; -.
DR   HSSP; P35505; 1HYO.
DR   InterPro; IPR002529; FAA_hydrolase.
DR   InterPro; IPR005959; Fum_ac_acetase.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   TIGRFAMs; TIGR01266; fum_ac_acetase; 1.
KW   Hydrolase; Phenylalanine catabolism; Tyrosine catabolism.
SQ   SEQUENCE   431 AA;  47011 MW;  E6C380CEFDCCAA67 CRC64;
     MASWLQIPKN SPFSLANIPF GIISSSKLSS RVPAIAIGDY ALDLSKFASS GGFSQLPVIQ
     PHLNVFKEST LNAFAALGRP VHRQVREYIQ KVFSTETPFP QILRDNAALQ KEALLPLSEV
     TNHLPMQIGD YTDFYAGLNH AYNVGVLFRG PDNALQPNYK HLPVAYHGRA SSVVTSGTPL
     HRPQGQILTN PAANPKLPTF SPCKKLDIEL ELAFFVSTPN DLGHPVHIDK AEDHIFGVVL
     MNDWSARDIQ AWEYVPLGPF NAKNFGTTIT PWVVLIDALE PFRTVGLEPG NRESLLPYLR
     EKRADTAYDI PLEVEVTNAG GEPTVISRSN AKNLLYSFPQ MLAHHTITGC NLNTGDLLGS
     GTISGKENQT EGSFLEQTNG KNPIKLADGS ERLFLEDGDT VILRGMAGTE GNYVGFGDCA
     GTILPPVQLD L
//