ID   ACEA_ASPFU     STANDARD;      PRT;   538 AA.
AC   Q6T267;
DT   25-OCT-2004 (Rel. 45, Created)
DT   25-OCT-2004 (Rel. 45, Last sequence update)
DT   25-JAN-2005 (Rel. 46, Last annotation update)
DE   Isocitrate lyase (EC 4.1.3.1) (Isocitrase) (Isocitratase) (ICL).
GN   Name=icl1; Synonyms=icl;
OS   Aspergillus fumigatus (Sartorya fumigata).
OC   Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=5085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Shankar J., Madan T., Sarma P.U.;
RT   "Aspergillus fumigatus isocitrate lyase (icl) gene.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Isocitrate = succinate + glyoxylate.
CC   -!- PATHWAY: Glyoxylate bypass; first step.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisomal (By similarity).
CC   -!- SIMILARITY: Belongs to the isocitrate lyase family.
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DR   EMBL; AY442291; AAR15146.1; -.
DR   InterPro; IPR006254; Isocit_lyase.
DR   InterPro; IPR000918; Isocit_lyase_ph.
DR   Pfam; PF00463; ICL; 1.
DR   ProDom; PD001857; Isocit_lyase_ph; 1.
DR   TIGRFAMs; TIGR01346; isocit_lyase; 1.
DR   PROSITE; PS00161; ISOCITRATE_LYASE; 1.
KW   Glyoxylate bypass; Lyase; Peroxisome; Tricarboxylic acid cycle.
FT   ACT_SITE    205    205       By similarity.
SQ   SEQUENCE   538 AA;  60231 MW;  0D7AF9A5C8CF261C CRC64;
     MGFLEDEDQK YWDDVQAVKA WWKDSRWRYT KRPYTAEQIV AKRGNLKIHY PSNDQSKKLW
     KILESNFDKV ASFTYGCLEP TMLTQMAKYL DTVYVSGWQS SSTASSTDEP SPDLADYPMN
     TVPNKVNQLF MAQLFHDRKQ REERITTPKD QRSKLPNIDY LRPIIADADT GHGGLTAVMK
     LTKLFIERGA AGIHIEDQAP GTKKCGHMAG KVLVPISEHI NRLVAIRAQA DIMGETDLLA
     IARTDSEAAT LITSTIDHRD HAFIVGSTNP NLQPLNDLML AGEQAGKTGE ELQAIEDQWI
     AQAGLKLFDD AVVDTIKAGV HVNKDALIKE YLTAAKGKSN SEARAIAKGI TGVDIYWDWD
     APRTREGYYR YQGGTQCAIN RAVAYAPFAD LIWMESKLPD YAQAKEFADG VHAVWPEQKL
     AYNLSPSFNW KKAMPREEQE TYIKRLGALG YAWQFITLAG LHTTALISDQ FARAYAKQGM
     RAYGELVQEP EMEQGVDVVT HQKWSGANYV DNMLKMLTGG VSSTAAMGKG VTEDQFKH
//