ID   HISX_AZOBR     STANDARD;      PRT;   128 AA.
AC   P18786;
DT   01-NOV-1990 (Rel. 16, Created)
DT   01-NOV-1990 (Rel. 16, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Putative histidinol dehydrogenase (EC 1.1.1.23) (HDH) (Fragment).
GN   Name=hisD;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sp6;
RX   MEDLINE=89313660; PubMed=2664449;
RA   Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C.,
RA   Sgaramella V., Polsinelli M.;
RT   "Cloning of histidine genes of Azospirillum brasilense: organization
RT   of the ABFH gene cluster and nucleotide sequence of the hisB gene.";
RL   Mol. Gen. Genet. 216:224-229(1989).
CC   -!- FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-
CC       histidinol to L-histidinaldehyde and then to L-histidine (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: L-histidinol + 2 NAD(+) = L-histidine + 2
CC       NADH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from PRPP: step 9 [final step].
CC   -!- SIMILARITY: Belongs to the histidinol dehydrogenase family.
CC   -!- CAUTION: Highly divergent compared to other bacterial hisD.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; X17435; CAA35477.1; -.
DR   PIR; PE0006; PE0006.
DR   HAMAP; MF_01024; atypical; 1.
DR   InterPro; IPR001692; Histidinol_dh.
DR   PROSITE; PS00611; HISOL_DEHYDROGENASE; PARTIAL.
KW   Histidine biosynthesis; NAD; Oxidoreductase.
FT   NON_TER       1      1
SQ   SEQUENCE   128 AA;  14111 MW;  BDF52031D2B04CCD CRC64;
     ILVQTAPAGP IDVLIGRPAL QRPDIAPRHH APPHRAEREA VEADRSRRTA GDGWGFAGLR
     QLPAHAGGQH QQGREGQEKA SGRRHVRCHI PLCALSVHTT MHTHALSGIA TDGHRRFRRR
     HLCRPRAS
//