ID   HIS7_AZOBR     STANDARD;      PRT;   207 AA.
AC   P18787;
DT   01-NOV-1990 (Rel. 16, Created)
DT   01-NOV-1990 (Rel. 16, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD).
GN   Name=hisB;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sp6;
RX   MEDLINE=89313660; PubMed=2664449;
RA   Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C.,
RA   Sgaramella V., Polsinelli M.;
RT   "Cloning of histidine genes of Azospirillum brasilense: organization
RT   of the ABFH gene cluster and nucleotide sequence of the hisB gene.";
RL   Mol. Gen. Genet. 216:224-229(1989).
CC   -!- CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-
CC       phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from PRPP: step 6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity).
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; X17435; CAA35478.1; -.
DR   EMBL; X61207; CAA43515.1; -.
DR   PIR; JE0045; JE0045.
DR   HAMAP; MF_00076; -; 1.
DR   InterPro; IPR000807; IGPD.
DR   Pfam; PF00475; IGPD; 1.
DR   ProDom; PD002282; IGPD; 1.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR   PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
KW   Histidine biosynthesis; Lyase.
SQ   SEQUENCE   207 AA;  22666 MW;  1D5EC1D4AA0EB8DB CRC64;
     MDQSLANGVG GASIERNTTE TRIRVAVNLD GTGVYDVKTG VGFLDHMLEQ LSRHSLMDLS
     VAAEGDVHID AHHTTEHSGI AIGQAVAKAV GDRKGIQRYG HAYVPMDETL TRVALDFSNR
     PYLIWKVSFS RDKIGDMDTE LFREWFQAFA MAAGVTLHVE CLYGENNHHI VESCYKALAR
     ALRAGIEIDP RKRDAVPSTK GTLGGSL
//