ID   HIS4_AZOBR     STANDARD;      PRT;   254 AA.
AC   P26720;
DT   01-AUG-1992 (Rel. 23, Created)
DT   01-AUG-1992 (Rel. 23, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
DE   imidazole-4-carboxamide isomerase (EC 5.3.1.16)
DE   (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide
DE   isomerase).
GN   Name=hisA;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sp6;
RX   MEDLINE=89313660; PubMed=2664449;
RA   Fani R., Allotta G., Bazzicalupo M., Gallori E., Polsinelli M.;
RT   "Cloning of histidine genes of Azospirillum brasilense: organization
RT   of the ABFH gene cluster and nucleotide sequence of the hisB gene.";
RL   Mol. Gen. Genet. 216:224-229(1989).
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from PRPP: step 4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA / hisF family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; X61207; CAA43518.1; -.
DR   PIR; S16801; S16801.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR003009; FMN_enzyme.
DR   InterPro; IPR006063; His4.
DR   InterPro; IPR006062; His_biosynth.
DR   InterPro; IPR011060; RibP_bind_barrel.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00007; His4; 1.
KW   Histidine biosynthesis; Isomerase.
FT   ACT_SITE      8      8       Proton acceptor (By similarity).
FT   ACT_SITE    129    129       Proton donor (By similarity).
SQ   SEQUENCE   254 AA;  26791 MW;  CCE0E31126563973 CRC64;
     MIIYPAIDLK DGACVRLLRG EMSQATVFNT EPADQARLFE SQGFEWLHLV DLNGAFEGKP
     VNGKAVESIL GAVTVPVQLG GGIRDLKTIA LWLEKGVSRV ILGTVALREP ELVREARREF
     PGKVAVGIDA REGYVAVAGW AETSTIKALD LALKFEDSGV AAIIYTDINR DGAMGGVNVE
     ATSDLAFHLT TPVIASGAVS SIDDLIALKK EEDTGIQGVI CGRALYDGRI DPKTALDLLS
     SVSVSGTPVT GKAG
//