ID   HIS6_AZOBR     STANDARD;      PRT;   261 AA.
AC   P26721;
DT   01-AUG-1992 (Rel. 23, Created)
DT   01-AUG-1992 (Rel. 23, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Imidazole glycerol phosphate synthase subunit hisF (EC 4.1.3.-) (IGP
DE   synthase cyclase subunit) (IGP synthase subunit hisF) (ImGP synthase
DE   subunit hisF) (IGPS subunit hisF).
GN   Name=hisF;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sp6;
RX   MEDLINE=89313660; PubMed=2664449;
RA   Fani R., Allotta G., Bazzicalupo M., Gallori E., Polsinelli M.;
RT   "Cloning of histidine genes of Azospirillum brasilense: organization
RT   of the ABFH gene cluster and nucleotide sequence of the hisB gene.";
RL   Mol. Gen. Genet. 216:224-229(1989).
CC   -!- FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to
CC       IGP, AICAR and glutamate. The hisF subunit catalyzes the
CC       cyclization activity that produces IGP and AICAR from PRFAR using
CC       the ammonia provided by the hisH subunit (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-
CC       ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-
CC       carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-
CC       aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from PRPP: step 5.
CC   -!- SUBUNIT: Heterodimer of hisH and hisF (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA / hisF family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; X61207; CAA43519.1; -.
DR   PIR; S16802; S16802.
DR   HSSP; Q9X0C6; 1GPW.
DR   HAMAP; MF_01013; -; 1.
DR   InterPro; IPR003009; FMN_enzyme.
DR   InterPro; IPR006062; His_biosynth.
DR   InterPro; IPR004651; HisF.
DR   InterPro; IPR011060; RibP_bind_barrel.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00735; hisF; 1.
KW   Histidine biosynthesis; Lyase.
FT   ACT_SITE     11     11       Potential.
FT   ACT_SITE    130    130       Potential.
SQ   SEQUENCE   261 AA;  28061 MW;  2EEE810685953AFF CRC64;
     MLKMRVIPCL DVKDGRVVKG VNFVDLIDAG DPVEQARVYD REGADELTFL DITASHENRD
     TIYDVVRRTA EQVFMPLTVG GGVRTVDDIR KLLLAGADKV SINTAAIHRP EFVQEAAEKF
     GAQCIVVAID AKQVEPGRWE IFTHGGRKAT GIDAIEWAKR MESYGAGEIL LTSMDRDGTK
     SGFDLALTRK VADGLRIPVI ASGGVGTLDH LVEGIREGHA TAVLAASIFH FGTYTIGQAK
     AALAEAGIPV RPARMAEAAH G
//