ID   GCH2_AZOBR     STANDARD;      PRT;   385 AA.
AC   P43525;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   GTP cyclohydrolase II (EC 3.5.4.25).
GN   Name=ribA;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sp7 / ATCC 29145;
RX   MEDLINE=95189096; PubMed=7883178; DOI=10.1016/0378-1119(94)00826-E;
RA   van Bastelaere E., Keijers V., Vanderleyden J.;
RT   "Cloning and sequencing of the putative Azospirillum brasilense gene
RT   encoding GTP cyclohydrolase II.";
RL   Gene 153:141-142(1995).
CC   -!- CATALYTIC ACTIVITY: GTP + 3 H(2)O = formate + 2,5-diamino-6-
CC       hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate.
CC   -!- PATHWAY: Riboflavin biosynthesis.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the GTP
CC       cyclohydrolase II family.
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DR   EMBL; U09869; AAA82170.1; -.
DR   PIR; I39498; I39498.
DR   HAMAP; MF_00179; fused; 1.
DR   InterPro; IPR000422; DHBP_synthase.
DR   InterPro; IPR000926; GTP_cyclohydroII.
DR   Pfam; PF00926; DHBP_synthase; 1.
DR   Pfam; PF00925; GTP_cyclohydro2; 1.
DR   TIGRFAMs; TIGR00505; ribA; 1.
KW   Hydrolase; Riboflavin biosynthesis.
FT   DOMAIN        1    189       Unknown.
FT   DOMAIN      190    385       GTP cyclohydrolase II.
SQ   SEQUENCE   385 AA;  40972 MW;  A98C225E2B068536 CRC64;
     MYADAPSDSA PPEAVLPMDE AAMRAVDRAT AALRRGEAVA IETADGSVGA AVSVESVAID
     AVQRLVQLTG AAPVLAVTRR RATVLKLMGE GTGVVALSLP RCLTADEAHA LADPEHRPDG
     DMPDGLTATA MDPGSRETAA VDLARLARLL PAAIVAPATD HTGSAAEWAA EHDLLLVRAR
     DIADYRVHVV RTLRRVAEAR VPLSGAENTS IAAFRPIDGG PEHLAIIVGN PVAGEPVLAR
     LHSECFTGDL LAGLRCDCGQ QLRGAIAEIA RHGSGVLLYL AQEGRGIGLV NKLRAYRIQD
     RGFDTVDANE ILGFEADERV YLPAAEMLRQ LGFTAVRLMT NNPEKLRQLA RCGIEVVERV
     PHIFPANGHN EGYLRTKAER SGHMF
//