ID   NTRB_AZOBR     STANDARD;      PRT;   400 AA.
AC   P45670;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   Nitrogen regulation protein ntrB (EC 2.7.3.-).
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sp7 / ATCC 29145;
RX   MEDLINE=96002420; PubMed=7553451;
RA   Machado H.B., Yates M.G., Funayama S., Rigo L.U., Steffens M.B.R.,
RA   Souza E.M., Pedrosa F.O.;
RT   "The ntrBC genes of Azospirillum brasilense are part of a nifR3-like-
RT   ntrB-ntrC operon and are negatively regulated.";
RL   Can. J. Microbiol. 41:674-684(1995).
CC   -!- FUNCTION: NtrB acts as a signal transducer which responds to the
CC       nitrogen level of cell and modulates the activity of ntrC. In
CC       nitrogen limitation ntrB activates ntrC by phosphorylating it,
CC       while in nitrogen excess ntrC is dephosphorylated and consequently
CC       inactivated by ntrB.
CC   -!- SIMILARITY: Contains 1 histidine kinase domain.
CC   -!- SIMILARITY: Contains 1 PAS (PER-ARNT-SIM) dimerization domain.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; Z37984; CAA86064.1; -.
DR   PIR; I39493; I39493.
DR   InterPro; IPR003594; ATPbind_ATPase.
DR   InterPro; IPR004358; Bact_sens_pr_C.
DR   InterPro; IPR009082; His_kin_homodim.
DR   InterPro; IPR003661; His_kinA_N.
DR   InterPro; IPR005467; His_kinase.
DR   InterPro; IPR000014; PAS.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00989; PAS; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00091; PAS; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50112; PAS; 1.
KW   ATP-binding; Kinase; Nitrogen fixation; Phosphorylation;
KW   Sensory transduction; Transferase; Two-component regulatory system.
FT   DOMAIN       29     99       PAS.
FT   DOMAIN      163    381       Histidine kinase.
FT   MOD_RES     166    166       Phosphohistidine (by autocatalysis) (By
FT                                similarity).
SQ   SEQUENCE   400 AA;  43406 MW;  28AC58224489D218 CRC64;
     MARASAAAPL PRRPARPRAP SSSYRPVRPC IDPSVMLNAL PDPVLVVDGS GDIRYVNLEA
     QEFFGLSAAM MEGMPLAELL PPNSPVSQLI EQVQQGRHRA SQEGVVIDTP RIGPHHVTVR
     VTALGEPADH VLLTVNERTL ARKIDNSLTH RNAARSVTAM ASMLGHEVKN PLSGIRGAAQ
     LLEENCSESD RVLTRLICDE ADRIVALVNR MEVFSDQRPL ERDAVNIHTV LEHVRKVAQS
     GFARNIRFIE RYDPSLPPVY GNRDQLIQIF LNLIKNAAEA APESGGEIIL STSYQHGVRM
     ALPGGDTRLH LPLLVSVQDN GDGIPDDLRS NLFDAFITTK VNGTGLGLAL VAKIVGDHGG
     VIEFDSQPRR TVFKVSLPMF DEAQMSGDPA PARGIRGAIG
//