ID   DHAS_AZOVI     STANDARD;      PRT;   368 AA.
AC   P96198;
DT   01-NOV-1997 (Rel. 35, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) (ASA dehydrogenase)
DE   (ASADH).
GN   Name=asd;
OS   Azotobacter vinelandii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Azotobacter.
OX   NCBI_TaxID=354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UW;
RX   MEDLINE=97261869; PubMed=9108283; DOI=10.1007/s004380050409;
RA   Manna A.C., Das H.K.;
RT   "Characterization and mutagenesis of the leucine biosynthetic genes of
RT   Azotobacter vinelandii: an analysis of the rarity of amino acid
RT   auxotrophs.";
RL   Mol. Gen. Genet. 254:207-217(1997).
CC   -!- CATALYTIC ACTIVITY: L-aspartate 4-semialdehyde + phosphate +
CC       NADP(+) = L-4-aspartyl phosphate + NADPH.
CC   -!- PATHWAY: Second step in the common biosynthetic pathway leading
CC       from Asp to the cell wall precursor meso-diaminopimelate, to Lys,
CC       to Met, to Ile and to Thr.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase
CC       family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; Y11280; CAA72152.1; -.
DR   HSSP; P00353; 1BRM.
DR   InterPro; IPR000319; Asp_semiald_dh.
DR   InterPro; IPR000534; Semialdh_dh.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   Pfam; PF02774; Semialdhyde_dhC; 1.
DR   TIGRFAMs; TIGR01745; asd_gamma; 1.
DR   PROSITE; PS01103; ASD; 1.
KW   Diaminopimelate biosynthesis; Lysine biosynthesis; NADP;
KW   Oxidoreductase.
FT   ACT_SITE    134    134       Acyl-thioester intermediate (By
FT                                similarity).
SQ   SEQUENCE   368 AA;  40388 MW;  0F9B62D790C0AAD5 CRC64;
     MKRVGLIGWR GMVGSVLMQR MLEERDFDLI EPVFFTTSSV GGQGAIGKET VPLKDAYSIE
     ELKSLDAIIT CQGGDYTSEV FPKLRDAGWQ GYWIDAASSL RMADDAVIVL DPVNRRVIDQ
     SLDAGVKNYI GGNCTVSLML MALGRLRGRP GRLDERHDLS GRFRAGAQNM RELIRQMGTI
     NAAVAAEPAD PASAILEIDR KGPETQRSAE FPVDHFGVPL AGSLIPYIDK ELPNGQSREE
     WKGQAETNKI LGRIKNPIPV DGICVRVGAM RCHSQALTIK LNKDVPIADI EGLISQHNPW
     VKLVPNHREA SMQELSPAAI TGTLTVPVGR LRKLNMGSQY LGAFTVGDQL LWGAAEPVRR
     MLLILLER
//