ID   DHAS_AZOVI     STANDARD;      PRT;   368 AA.
AC   P96198;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   16-MAY-2006, entry version 33.
DE   Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) (ASA dehydrogenase)
DE   (ASADH).
GN   Name=asd;
OS   Azotobacter vinelandii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Azotobacter.
OX   NCBI_TaxID=354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13705 / OP1 / DSM 366 / NCIB 11614 / LMG 3878 / UW;
RX   MEDLINE=97261869; PubMed=9108283; DOI=10.1007/s004380050409;
RA   Manna A.C., Das H.K.;
RT   "Characterization and mutagenesis of the leucine biosynthetic genes of
RT   Azotobacter vinelandii: an analysis of the rarity of amino acid
RT   auxotrophs.";
RL   Mol. Gen. Genet. 254:207-217(1997).
CC   -!- CATALYTIC ACTIVITY: L-aspartate 4-semialdehyde + phosphate +
CC       NADP(+) = L-4-aspartyl phosphate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 2.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis;
CC       L-homoserine from L-aspartate: step 2.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis;
CC       L-threonine from L-aspartate: step 2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; Y11280; CAA72152.1; -; Genomic_DNA.
DR   HSSP; P00353; 1BRM.
DR   InterPro; IPR000534; ADH_NAD_bd.
DR   InterPro; IPR011534; Asp_ADH_proteob.
DR   InterPro; IPR012080; Asp_sema_DH.
DR   InterPro; IPR000319; Asp_sema_DH_mic.
DR   InterPro; IPR012280; Semialdhyde_DH_C.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   Pfam; PF02774; Semialdhyde_dhC; 1.
DR   PIRSF; PIRSF000148; ASA_dh; 1.
DR   TIGRFAMs; TIGR01745; asd_gamma; 1.
DR   PROSITE; PS01103; ASD; 1.
KW   Amino-acid biosynthesis; Diaminopimelate biosynthesis;
KW   Lysine biosynthesis; NADP; Oxidoreductase.
FT   CHAIN         1    368       Aspartate-semialdehyde dehydrogenase.
FT                                /FTId=PRO_0000141360.
FT   ACT_SITE    134    134       Acyl-thioester intermediate (By
FT                                similarity).
SQ   SEQUENCE   368 AA;  40388 MW;  0F9B62D790C0AAD5 CRC64;
     MKRVGLIGWR GMVGSVLMQR MLEERDFDLI EPVFFTTSSV GGQGAIGKET VPLKDAYSIE
     ELKSLDAIIT CQGGDYTSEV FPKLRDAGWQ GYWIDAASSL RMADDAVIVL DPVNRRVIDQ
     SLDAGVKNYI GGNCTVSLML MALGRLRGRP GRLDERHDLS GRFRAGAQNM RELIRQMGTI
     NAAVAAEPAD PASAILEIDR KGPETQRSAE FPVDHFGVPL AGSLIPYIDK ELPNGQSREE
     WKGQAETNKI LGRIKNPIPV DGICVRVGAM RCHSQALTIK LNKDVPIADI EGLISQHNPW
     VKLVPNHREA SMQELSPAAI TGTLTVPVGR LRKLNMGSQY LGAFTVGDQL LWGAAEPVRR
     MLLILLER
//