ID   ADEC_BACSU     STANDARD;      PRT;   577 AA.
AC   P39761;
DT   01-FEB-1995 (Rel. 31, Created)
DT   01-FEB-1995 (Rel. 31, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Adenine deaminase (EC 3.5.4.2) (Adenase) (Adenine aminase).
GN   Name=adeC; Synonyms=ade; OrderedLocusNames=BSU14520;
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=168 / JH642;
RA   Kobayashi K., Sato T., Kobayashi Y.;
RT   "The nucleotide sequence analysis of kinC region.";
RL   Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE, CATALYTIC ACTIVITY, AND COFACTOR.
RC   STRAIN=168;
RX   MEDLINE=96146537; PubMed=8550522;
RA   Nygaard P., Duckert P., Saxild H.H.;
RT   "Role of adenine deaminase in purine salvage and nitrogen metabolism
RT   and characterization of the ade gene in Bacillus subtilis.";
RL   J. Bacteriol. 178:846-853(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=168;
RX   MEDLINE=97124187; PubMed=8969500;
RA   Winters P., Caldwell R., Enfield L., Ferrari E.;
RT   "The ampS-nprE (124 degrees-127 degrees) region of the Bacillus
RT   subtilis 168 chromosome: sequencing of a 27 kb segment and
RT   identification of several genes in the area.";
RL   Microbiology 142:3033-3037(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.K., Codani J.J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Dusterhoft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- CATALYTIC ACTIVITY: Adenine + H(2)O = hypoxanthine + NH(3).
CC   -!- COFACTOR: Manganese.
CC   -!- SIMILARITY: Belongs to the adenine deaminase family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; D37799; BAA07052.1; -.
DR   EMBL; X83795; CAA58726.1; -.
DR   EMBL; AF012285; AAC24927.1; -.
DR   EMBL; Z99111; CAB13325.1; -.
DR   PIR; B69583; B69583.
DR   SubtiList; BG11044; adeC.
DR   HAMAP; MF_01518; -; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR005847; DHOase.
DR   InterPro; IPR011059; Metalo_hydrolase.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   ProDom; PD001248; Amidohydro_like; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
KW   Complete proteome; Hydrolase; Manganese.
FT   CONFLICT    193    193       A -> G (in Ref. 2).
FT   CONFLICT    231    231       D -> Y (in Ref. 2).
FT   CONFLICT    262    265       RTPV -> ARRF (in Ref. 2).
SQ   SEQUENCE   577 AA;  62815 MW;  D5FABF90D2B0FF6E CRC64;
     MNKEALVNRL NASAKRQKAD IVIKNGKIMD VYNQEWIYED IAITDGVIVG LGEYEGENII
     DAEGQMIVPG FIDGHVHIES SMVTPIEFAK AVLPHGVTTV VTDPHEIANV SGEKGIEFML
     EQARHTPLNI HFMLPSSVPA ASFERSGAIL KAADLKPFYE EEEVLGLAEV MDYVSVQQAE
     KDMVQKLLDA RVAGKRIDGH LAGLSTDLIN IYRTAFVLND HEVTSKEEAL DRIRRGMYVM
     MREGSVAKNT LNVLPAVNEK NRTPVFFCTD DKHVDDLLSE GSVNHQVKMA IQAGLNPFLA
     YQLGSLNAAE CYGLDTKGAI APGFDADLLF VSDLENVTVT MTMVKGQTVA EDSKAVYQDH
     ASTAAPDQAL LDSVKLAAPL NKQDFHMPID SEQQINVIQI IPNQLETRLV QVPAPVAREF
     EPDTELDLLK IAVVERHKGL KETGLGVVKG FGFKSGAIAT TISHDSHNII AVGTNDEDIA
     AAVNKLQEIG GGLTIIKNGE ELHSVPLPIA GLLSDQSAEQ VNQSLLTLHD KLSLIGFTGG
     FNPFLTLSFL ALPVIPDIKM TTTGLFDVKS FQHISLQ
//