ID   ALSR_BACSU     STANDARD;      PRT;   302 AA.
AC   Q04778;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   07-MAR-2006, entry version 45.
DE   HTH-type transcriptional regulator alsR (Als operon regulatory
DE   protein).
GN   Name=alsR; OrderedLocusNames=BSU36020;
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93286000; PubMed=7685336;
RA   Renna M.C., Najimudin N., Winik L.R., Zahler S.A.;
RT   "Regulation of the Bacillus subtilis alsS, alsD, and alsR genes
RT   involved in post-exponential-phase production of acetoin.";
RL   J. Bacteriol. 175:3863-3875(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98015417; PubMed=9353933;
RA   Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA   Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H.,
RA   Villani G., Kunst F., Danchin A., Glaser P.;
RT   "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT   degrees).";
RL   Microbiology 143:3313-3328(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Regulates the expression of the alsSD operon for acetoin
CC       biosynthesis.
CC   -!- SIMILARITY: Contains 1 HTH lysR-type DNA-binding domain.
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DR   EMBL; L04470; AAA22221.1; -; Genomic_DNA.
DR   EMBL; Z93767; CAB07788.1; -; Genomic_DNA.
DR   EMBL; Z99122; CAB15619.1; -; Genomic_DNA.
DR   PIR; A47126; A47126.
DR   SubtiList; BG10470; alsR.
DR   GenomeReviews; AL009126_GR; BSU36020.
DR   BioCyc; BSUB1423:BSU3600-MONOMER; -.
DR   InterPro; IPR000847; HTH_LysR.
DR   InterPro; IPR005119; LysR_subst_bd.
DR   InterPro; IPR011991; Wing_hlx_DNA_bd.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   PROSITE; PS50931; HTH_LYSR; 1.
KW   Acetoin biosynthesis; Complete proteome; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    302       HTH-type transcriptional regulator alsR.
FT                                /FTId=PRO_0000105584.
FT   DOMAIN        1     58       HTH lysR-type.
FT   DNA_BIND     18     37       H-T-H motif (By similarity).
SQ   SEQUENCE   302 AA;  34333 MW;  BCA4DF5CF95A3E33 CRC64;
     MELRHLQYFI AVAEELHFGK AARRLNMTQP PLSQQIKQLE EEVGVTLLKR TKRFVELTAA
     GEIFLNHCRM ALMQIGQGIE LAQRTARGEQ GLLVIGFVGS ATYEFLPPIV REYRKKFPSV
     KIELREISSS RQQEELLKGN IDIGILHPPL QHTALHIETA QSSPCVLALP KQHPLTSKES
     ITIEDLRDEP IITVAKEAWP TLYMDFIQFC EQAGFRPNIV QEATEYQMVI GLVSAGIGMT
     FVPSSAKKLF NLDVTYRKMD QIQLNAEWVI AYRKDNHNPL IKHFIHISNC QQTRTKESDA
     GT
//