ID   ACEA_BACHD     STANDARD;      PRT;   427 AA.
AC   Q9K9H0;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   Isocitrate lyase (EC 4.1.3.1) (Isocitrase) (Isocitratase) (ICL).
GN   Name=aceA; OrderedLocusNames=BH2677;
OS   Bacillus halodurans.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=86665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C-125 / JCM 9153;
RX   MEDLINE=20512582; PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA   Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA   Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT   halodurans and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY: Isocitrate = succinate + glyoxylate.
CC   -!- PATHWAY: Glyoxylate bypass; first step.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic.
CC   -!- SIMILARITY: Belongs to the isocitrate lyase family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
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DR   EMBL; AP001516; BAB06396.1; -.
DR   PIR; E83984; E83984.
DR   HSSP; P05313; 1IGW.
DR   InterPro; IPR006254; Isocit_lyase.
DR   InterPro; IPR000918; Isocit_lyase_ph.
DR   Pfam; PF00463; ICL; 1.
DR   ProDom; PD001857; Isocit_lyase_ph; 1.
DR   TIGRFAMs; TIGR01346; isocit_lyase; 1.
DR   PROSITE; PS00161; ISOCITRATE_LYASE; 1.
KW   Complete proteome; Glyoxylate bypass; Lyase; Tricarboxylic acid cycle.
FT   ACT_SITE    188    188       By similarity.
SQ   SEQUENCE   427 AA;  46783 MW;  0C52D4A9F89E0DFE CRC64;
     MSGWQETAEK LEMSWSNDVR WQGVERPYSG EEVVKLRGSL KIEYTLAKTG AEKLWKLLHE
     EDYVNALGAM TGGQAIQQVK AGLKAIYLSG WQVAADANLA GHMYPDQSLY PANSVPSVVK
     RINQALQRAD QIQHLEGEGE VDYFAPIVAD AEAGFGGQLN VFELMKAMIE AGASGVHFED
     QLASEKKCGH LGGKVLIPTQ TAIRNLVSAR LAADVMGVPT ILVARTDADA ADLITSDIDP
     ADQRFITGER TPEGFYRTNA GIEQAIARGL AYAPYADLIW CETSKPSLEE AKQFADAIHE
     KFPGKLLAYN CSPSFNWEAN LDRATIETFQ QELGKMGYKF QFVTLAGFHA LNHSMFELAY
     GYKQRGMGAY SELQQAEFAS EVKGYTATRH QREVGTGYFD QVAQTITGGT SSTTALTGST
     EEAQFQK
//