ID   GLYA_MYCH2     STANDARD;      PRT;   418 AA.
AC   Q601P7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   07-MAR-2006, entry version 11.
DE   Serine hydroxymethyltransferase (EC 2.1.2.1) (Serine methylase)
DE   (SHMT).
GN   Name=glyA; OrderedLocusNames=mhp154;
OS   Mycoplasma hyopneumoniae (strain 232).
OC   Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=295358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15489423; DOI=10.1128/JB.186.21.7123-7133.2004;
RA   Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M.,
RA   Mahairas G.G.;
RT   "The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent
RT   of swine mycoplasmosis.";
RL   J. Bacteriol. 186:7123-7133(2004).
CC   -!- FUNCTION: Interconversion of serine and glycine.
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine +
CC       H(2)O = tetrahydrofolate + L-serine.
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- PATHWAY: Key enzyme in the biosynthesis of purines, lipids,
CC       hormones and other components.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SHMT family.
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DR   EMBL; AE017332; AAV27431.1; -; Genomic_DNA.
DR   GenomeReviews; AE017332_GR; mhp154.
DR   HAMAP; MF_00051; -; 1.
DR   InterPro; IPR001085; Gly_Hymtfrase.
DR   PANTHER; PTHR11680; Gly_Hymtfrase; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   PIRSF; PIRSF000412; SHMT; 1.
DR   PROSITE; PS00096; SHMT; 1.
KW   Complete proteome; One-carbon metabolism; Pyridoxal phosphate;
KW   Transferase.
FT   CHAIN         1    418       Serine hydroxymethyltransferase.
FT                                /FTId=PRO_0000113610.
FT   BINDING     226    226       Pyridoxal phosphate (covalent) (By
FT                                similarity).
SQ   SEQUENCE   418 AA;  46507 MW;  018ED794FAA5A728 CRC64;
     MYKKIKLRDQ QISELINLES KRQNSQIELI ASENYASEDV ILANGTSLSN KYGEGYPGKR
     YYGGCTFIDQ IEKIAIERVK KLFKIEYANV QPYSGSSANA AVFAALLKPG DKILGLDLNA
     GGHLSHGYKI NFSGMFYSGI SYFLDENELL DYDAIEKIAL KTKPNLIICG YSAYSRKIDF
     ARFRQIADKV NAFLLADIAH IAGLIAAGQH PSPVGYAHII TSTTQKTLRG PRGGLILTNS
     KEIAAKIDKV VFPGIQGGPF FHTIAAKAVA FKEALEPWFK EYCAQIVKNA SHFASEFIKK
     GIRIVSQGTE NHLFTIDVLS SYNLNGKQAQ ILLESVNIIT NKNTIPNDTL SPFVTSGLRL
     GTPAMTSRGF KEQEFSQMAE IIDFVLRKKE LNALEIKEIK KKVKILTKNF PIKKSYWP
//