ID   BPHI_BURCE     STANDARD;      PRT;   346 AA.
AC   P51015;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   07-FEB-2006, entry version 23.
DE   4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-) (HOA).
GN   Name=bphI;
OS   Burkholderia cepacia (Pseudomonas cepacia).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LB400;
RX   MEDLINE=94299175; PubMed=8026764; DOI=10.1016/0378-1119(94)90196-1;
RA   Hofer B., Backhaus S., Timmis K.N.;
RT   "The biphenyl/polychlorinated biphenyl-degradation locus (bph) of
RT   Pseudomonas sp. LB400 encodes four additional metabolic enzymes.";
RL   Gene 144:9-16(1994).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxy-2-oxovalerate = pyruvate +
CC       acetaldehyde.
CC   -!- PATHWAY: Biphenyl and polychlorinated biphenyl degradation.
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DR   EMBL; X76500; CAA54036.1; -; Genomic_DNA.
DR   HSSP; P51016; 1NVM.
DR   InterPro; IPR012425; DmpG_comm.
DR   InterPro; IPR000891; PYR_CT.
DR   Pfam; PF07836; DmpG_comm; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
KW   Aromatic hydrocarbons catabolism; Lyase.
FT   CHAIN         1    346       4-hydroxy-2-oxovalerate aldolase.
FT                                /FTId=PRO_0000064978.
SQ   SEQUENCE   346 AA;  36872 MW;  3E7895034B987D85 CRC64;
     MKLEGKKVTV HDMTLRDGMH PKRHQMTLEQ MKSIACGLDA AGIPLIEVTH GDGLGGSSVN
     YGFPAHSDEE YLGAVIPLMK QAKVSALLLP GIGTVEHLKM AKDLGVNTIR VATHCTEADV
     SEQHITQSRK LGLDTVGFLM MAHMASPEKL VSQALLMQGY GANCIYVTDS AGYMLPDDVK
     ARLSAVRAAL KPETELGFHG HHNLAMGVAN SIAAIEAGAT RIDAAAAGLG AGAGNTPMEV
     FIAVCARMGI ETGVDVFKIQ DVSEDLVVPI MDHVIRIDRD SLTLGYAGVY SSFLLFAKRA
     SEKYGVPARD ILVELGRRGM VGGQEDMIED TAMTMARERG LTLTAA
//