ID   GSHR_BURCE     STANDARD;      PRT;   449 AA.
AC   P48639;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   07-MAR-2006, entry version 47.
DE   Glutathione reductase (EC 1.8.1.7) (GR) (GRase).
GN   Name=gor;
OS   Burkholderia cepacia (Pseudomonas cepacia).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AC1100;
RX   MEDLINE=95266809; PubMed=7538273;
RA   Daubaras D.L., Hershberger C.D., Kitano K., Chakrabarty A.M.;
RT   "Sequence analysis of a gene cluster involved in metabolism of
RT   2,4,5-trichlorophenoxyacetic acid by Burkholderia cepacia AC1100.";
RL   Appl. Environ. Microbiol. 61:1279-1289(1995).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + NADP(+) = glutathione
CC       disulfide + NADPH.
CC   -!- COFACTOR: Binds 1 FAD per subunit (By similarity).
CC   -!- PATHWAY: 2,4,5-trichlorophenoxyacetic acid degradation.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: The active site is a redox-active disulfide bond.
CC   -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC       oxidoreductase family.
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DR   EMBL; U19883; AAC43334.1; -; Genomic_DNA.
DR   PIR; I40178; I40178.
DR   HSSP; Q94655; 1ONF.
DR   InterPro; IPR013027; FAD_pyr_redox.
DR   InterPro; IPR006324; Glut_reduct_pln.
DR   InterPro; IPR000815; Hg_reductase.
DR   InterPro; IPR001100; Pyr_redox.
DR   InterPro; IPR004099; Pyr_redox_dim.
DR   InterPro; IPR012999; Pyr_redox_I_AS.
DR   InterPro; IPR001327; Pyr_redox_NAD_bd.
DR   Pfam; PF00070; Pyr_redox; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF02852; Pyr_redox_dim; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00945; HGRDTASE.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   ProDom; PD000139; FAD_pyr_redox; 1.
DR   TIGRFAMs; TIGR01424; gluta_reduc_2; 1.
DR   PROSITE; PS00076; PYRIDINE_REDOX_1; 1.
KW   FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
FT   CHAIN         1    449       Glutathione reductase.
FT                                /FTId=PRO_0000067974.
FT   NP_BIND      35     43       FAD (ADP part) (By similarity).
FT   ACT_SITE    435    435       Proton acceptor (By similarity).
FT   DISULFID     43     48       Redox-active (By similarity).
SQ   SEQUENCE   449 AA;  47541 MW;  402FCC6E7A8D6720 CRC64;
     MQKYDFDLFV IGAGSGGVRA ARIAAGHGAK VAIAEEYRFG GTCVIRGCVP KKLLMYASQY
     GQGFEDAAGF GWHSAATSHS WTSLIAAKDA EIARLEGVYQ RLIENANVEI FKGRAQIAGP
     NRVTVTGASV SARTILIATG ARPVMPPVAG ANLMITSDDV FDLPVGPPRI AIIGGGYIAC
     EFAGIFNGLG RHVVQLHRGS QVLRGFDDEL REHLGDELKK SGIDLRLGVD VVAVERQRGA
     LSVQLTTGDA MEVDAVMAAT GRLPNTWGLG LETVDVGLDQ NGAIKVDEYS RTSSPGIYAV
     GDVTNRLNLT PVAIHEGHAF ADTVFGGKAL PTEHENVPFA VFSQPQAASV GLSEAQARDR
     YSNVEIYGSA FRPMRAALSG RDEKALVKLV VNGSNDRVVG AHIVGADAAE IIQGIAVAIK
     ARATKADFDA TLGVHPTLAE EFVTLRNRR
//