ID ARLY_BURCE STANDARD; PRT; 469 AA. AC P59615; DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot. DT 23-APR-2003, sequence version 1. DT 16-MAY-2006, entry version 20. DE Argininosuccinate lyase (EC 4.3.2.1) (Arginosuccinase) (ASAL). GN Name=argH; OS Burkholderia cepacia (Pseudomonas cepacia). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex. OX NCBI_TaxID=292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 17616 / 249; RX MEDLINE=22638290; PubMed=12754231; RX DOI=10.1128/JB.185.11.3333-3343.2003; RA Komatsu H., Imura Y., Ohori A., Nagata Y., Tsuda M.; RT "Distribution and organization of auxotrophic genes on the RT multichromosomal genome of Burkholderia multivorans ATCC 17616."; RL J. Bacteriol. 185:3333-3343(2003). CC -!- CATALYTIC ACTIVITY: (N(omega)-L-arginino)succinate = fumarate + CC L-arginine. CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; CC L-arginine from L-ornithine and carbamoyl phosphate: step 3 [final CC step]. CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable). CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase CC subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AB091437; BAC65282.1; -; Genomic_DNA. DR HSSP; P04424; 1AOS. DR HAMAP; MF_00006; -; 1. DR InterPro; IPR009049; argH. DR InterPro; IPR003031; D_crystallin. DR InterPro; IPR000362; Fumarate_lyase. DR InterPro; IPR008948; L-Aspartase-like. DR Pfam; PF00206; Lyase_1; 1. DR PRINTS; PR00145; DCRYSTALLIN. DR PRINTS; PR00149; FUMRATELYASE. DR TIGRFAMs; TIGR00838; argH; 1. DR PROSITE; PS00163; FUMARATE_LYASES; 1. KW Amino-acid biosynthesis; Arginine biosynthesis; Lyase. FT CHAIN 1 469 Argininosuccinate lyase. FT /FTId=PRO_0000137752. SQ SEQUENCE 469 AA; 51328 MW; 3BB758C89B16E3F1 CRC64; MTSQLHKKGE AWSARFSEPM SELVKRYTSS VFFDKRLALV DIAGSLAHAN MLAAQKIISA DDLAAIERGM AQIKGEIERG EFEWQLDLED VHLNIEARLT ALIGDAGKRL HTGRSRNDQV ATDIRLWLRG EIDRIGGLLN DLRGALIDLA EQNADTIMPG FTHLQVAQPV TFGHHLLAYV EMFSRDAERM RDCRTRVNRL PLGAAALAGT SYPIDRHAVA KSLGFDGICA NSLDAVSDRD FAIEFTAAAA LVMTHVSRFS EELVLWMSPR VGFIDIADRF CTGSSIMPQK KNPDVPELAR GKTGRVNGHL MALLTLMKGQ PLAYNKDNQE DKEPLFDTVD TVADTLRIFA EMVAGITVKP DAMRAAALQG FSTATDLADY LVKRGLPFRD AHEAVAHAVK ICDDRGIDLA DLTLDEMKRE LPNVAQLIGD DVFDYLTLEG SVASRNHPGG TAPDQVRAAA QAARAALGK //