ID   GMHA_BURPS     STANDARD;      PRT;   197 AA.
AC   Q93UJ2; Q63R78;
DT   28-FEB-2003 (Rel. 41, Created)
DT   01-FEB-2005 (Rel. 46, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Phosphoheptose isomerase (EC 5.3.1.-) (Sedoheptulose 7-phosphate
DE   isomerase).
GN   Name=gmhA; OrderedLocusNames=BPSL2795;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=20569162; PubMed=11119486; DOI=10.1128/IAI.69.1.34-44.2001;
RA   Reckseidler S.L., DeShazer D., Sokol P.A., Woods D.E.;
RT   "Detection of bacterial virulence genes by subtractive hybridization:
RT   identification of capsular polysaccharide of Burkholderia pseudomallei
RT   as a major virulence determinant.";
RL   Infect. Immun. 69:34-44(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L.,
RA   Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R.,
RA   Brooks K., Brown K.A., Brown N.F., Challis G.L., Cherevach I.,
RA   Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D.,
RA   Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K.,
RA   Keith K.E., Maddison M., Moule S., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA   Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis,
RT   Burkholderia pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
RN   [3]
RP   BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE.
RX   PubMed=12101286;
RA   Valvano M.A., Messner P., Kosma P.;
RT   "Novel pathways for biosynthesis of nucleotide-activated glycero-
RT   manno-heptose precursors of bacterial glycoproteins and cell surface
RT   polysaccharides.";
RL   Microbiology 148:1979-1989(2002).
CC   -!- FUNCTION: Catalyzes the isomerization of sedoheptulose 7-phosphate
CC       in D-glycero-D-manno-heptose 7-phosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: D-sedoheptulose 7-phosphate = D-glycero-alpha-
CC       D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-
CC       phosphate.
CC   -!- PATHWAY: Capsular polysaccharide (CPS) biosynthesis; GDP-D-
CC       glycero-alpha-D-manno-heptose biosynthesis; first step.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity).
CC   -!- SIMILARITY: Belongs to the SIS family. GmhA subfamily.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF228583; AAK49808.1; -.
DR   EMBL; BX571965; CAH36804.1; -.
DR   HAMAP; MF_00067; -; 1.
DR   InterPro; IPR004515; GmhA.
DR   InterPro; IPR001347; SIS.
DR   Pfam; PF01380; SIS; 1.
DR   TIGRFAMs; TIGR00441; gmhA; 1.
KW   Bacterial capsule; Carbohydrate metabolism; Complete proteome;
KW   Isomerase.
FT   CONFLICT     34     34       R -> Q (in Ref. 1).
FT   CONFLICT    115    115       E -> K (in Ref. 1).
SQ   SEQUENCE   197 AA;  20813 MW;  22A249C834AC585B CRC64;
     MENRELTYIT NSIAEAQRVM AAMLADERLL ATVRKVADAC IASIAQGGKV LLAGNGGSAA
     DAQHIAGEFV SRFAFDRPGL PAVALTTDTS ILTAIGNDYG YEKLFSRQVQ ALGNEGDVLI
     GYSTSGKSPN ILAAFREAKA KGMTCVGFTG NRGGEMRELC DLLLEVPSAD TPKIQEGHLV
     LGHIVCGLVE HSIFGKQ
//