ID   APAH_BURMA     STANDARD;      PRT;   282 AA.
AC   Q9AEV8; Q62I92;
DT   28-FEB-2003 (Rel. 41, Created)
DT   01-FEB-2005 (Rel. 46, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41)
DE   (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Diadenosine 5',5'''-
DE   P1,P4-tetraphosphate pyrophosphohydrolase).
GN   Name=apaH; OrderedLocusNames=BMA1991;
OS   Burkholderia mallei (Pseudomonas mallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=13373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21650683; PubMed=11790757;
RA   Burtnick M.N., Brett P.J., Woods D.E.;
RT   "Molecular and physical characterization of Burkholderia mallei O
RT   antigens.";
RL   J. Bacteriol. 184:849-852(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23344;
RX   PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA   Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA   Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M.,
RA   Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F.,
RA   Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M.,
RA   Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y.,
RA   Zafar N., Zhou L., Fraser C.M.;
RT   "Structural flexibility in the Burkholderia mallei genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AY028370; AAK27390.1; -.
DR   EMBL; CP000010; AAU49991.1; -.
DR   TIGR; BMA1991; -.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   InterPro; IPR006186; T_phtase_apaH.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   ProDom; PD000252; T_phtase_apaH; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
KW   Complete proteome; Hydrolase.
FT   CONFLICT     90     90       T -> S (in Ref. 1).
FT   CONFLICT     96     96       D -> Y (in Ref. 1).
FT   CONFLICT    280    280       A -> P (in Ref. 1).
SQ   SEQUENCE   282 AA;  30572 MW;  665D4AA4D13EDF9D CRC64;
     MTNFSSSPPI AFGDLQGCHA AYRQLFDTLA PAADTPLWFA GDLVNRGPAS LATLREIAAL
     GERAIAVLGN HDLHLLAVAA GIRTLKPGDT IGEILDAPDA DDLIEWVRHR PFAHFERGML
     MVHAGLLPQW DAALALELAD ELQRALRASN WRDTLRSLYG NDPNCWSPDL KHADRLRVAF
     NAFTRIRFCT PEGAMEFRAN GGPAAAPAGY LPWFDAPGRK TADVTVVFGH WAALGLMLRE
     NLVALDSGCV WGNRLSAVRL ADDPAARVVT QVACERCGAA DE
//