ID   APAH_BURMA     STANDARD;      PRT;   282 AA.
AC   Q9AEV8; Q62I92;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   07-MAR-2006, entry version 26.
DE   Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41)
DE   (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Diadenosine 5',5'''-
DE   P1,P4-tetraphosphate pyrophosphohydrolase).
GN   Name=apaH; OrderedLocusNames=BMA1991;
OS   Burkholderia mallei (Pseudomonas mallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=13373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=21650683; PubMed=11790757;
RA   Burtnick M.N., Brett P.J., Woods D.E.;
RT   "Molecular and physical characterization of Burkholderia mallei O
RT   antigens.";
RL   J. Bacteriol. 184:849-852(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23344;
RX   PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA   Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA   Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M.,
RA   Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F.,
RA   Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M.,
RA   Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y.,
RA   Zafar N., Zhou L., Fraser C.M.;
RT   "Structural flexibility in the Burkholderia mallei genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; AY028370; AAK27390.1; -; Genomic_DNA.
DR   EMBL; CP000010; AAU49991.1; -; Genomic_DNA.
DR   GenomeReviews; CP000010_GR; BMA1991.
DR   TIGR; BMA1991; -.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   InterPro; IPR006186; T_phtase_apaH.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   ProDom; PD000252; T_phtase_apaH; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    282       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_0000197984.
FT   CONFLICT     90     90       T -> S (in Ref. 1).
FT   CONFLICT     96     96       D -> Y (in Ref. 1).
FT   CONFLICT    280    280       A -> P (in Ref. 1).
SQ   SEQUENCE   282 AA;  30572 MW;  665D4AA4D13EDF9D CRC64;
     MTNFSSSPPI AFGDLQGCHA AYRQLFDTLA PAADTPLWFA GDLVNRGPAS LATLREIAAL
     GERAIAVLGN HDLHLLAVAA GIRTLKPGDT IGEILDAPDA DDLIEWVRHR PFAHFERGML
     MVHAGLLPQW DAALALELAD ELQRALRASN WRDTLRSLYG NDPNCWSPDL KHADRLRVAF
     NAFTRIRFCT PEGAMEFRAN GGPAAAPAGY LPWFDAPGRK TADVTVVFGH WAALGLMLRE
     NLVALDSGCV WGNRLSAVRL ADDPAARVVT QVACERCGAA DE
//