ID   GMHB_BURMA     STANDARD;      PRT;   189 AA.
AC   Q9AI34; Q62HG5;
DT   25-OCT-2004 (Rel. 45, Created)
DT   25-OCT-2004 (Rel. 45, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   D,D-heptose 1,7-bisphosphate phosphatase (EC 3.1.3.-) (D-glycero-D-
DE   manno-heptose 1,7-bisphosphate phosphatase).
GN   Name=gmhB; Synonyms=wcbN; OrderedLocusNames=BMA2293;
OS   Burkholderia mallei (Pseudomonas mallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=13373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 23344;
RX   MEDLINE=21267073; PubMed=11373120; DOI=10.1006/mpat.2000.0430;
RA   DeShazer D., Waag D.M., Fritz D.L., Woods D.E.;
RT   "Identification of a Burkholderia mallei polysaccharide gene cluster
RT   by subtractive hybridization and demonstration that the encoded
RT   capsule is an essential virulence determinant.";
RL   Microb. Pathog. 30:253-269(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23344;
RX   PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA   Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA   Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M.,
RA   Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F.,
RA   Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M.,
RA   Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y.,
RA   Zafar N., Zhou L., Fraser C.M.;
RT   "Structural flexibility in the Burkholderia mallei genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
RN   [3]
RP   BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE.
RX   PubMed=12101286;
RA   Valvano M.A., Messner P., Kosma P.;
RT   "Novel pathways for biosynthesis of nucleotide-activated glycero-
RT   manno-heptose precursors of bacterial glycoproteins and cell surface
RT   polysaccharides.";
RL   Microbiology 148:1979-1989(2002).
CC   -!- FUNCTION: Converts the D-glycero-alpha-D-manno-heptose 1,7-
CC       bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1-
CC       phosphate by removing the phosphate group at the C-7 position (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: D-glycero-alpha-D-manno-heptose 1,7-
CC       bisphosphate + H(2)O = D-glycero-alpha-D-manno-heptose 1-phosphate
CC       + phosphate.
CC   -!- PATHWAY: Capsular polysaccharide (CPS) biosynthesis; GDP-D-
CC       glycero-alpha-D-manno-heptose biosynthesis; first step.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity).
CC   -!- MISCELLANEOUS: This enzyme is insensitive to the anomeric
CC       configuration of the D-glycero-D-manno-heptose 1,7-bisphosphate
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the gmhB family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF285636; AAK26470.1; -.
DR   EMBL; CP000010; AAU49840.1; -.
DR   TIGR; BMA2293; -.
DR   InterPro; IPR006549; HAD_SF-IIIA.
DR   InterPro; IPR006543; Histidinol-phos.
DR   InterPro; IPR004446; Hstdl_phs_rel.
DR   TIGRFAMs; TIGR00213; GmhB_yaeD; 1.
DR   TIGRFAMs; TIGR01662; HAD-SF-IIIA; 1.
DR   TIGRFAMs; TIGR01656; Histidinol-ppas; 1.
KW   Bacterial capsule; Carbohydrate metabolism; Complete proteome;
KW   Hydrolase.
SQ   SEQUENCE   189 AA;  20428 MW;  C176C93FCE0144B4 CRC64;
     MKNRALFLDR DGVINRDDGY VFEIEKFVFL DGIFELAGAA KALGYLSIVV TNQAGIGRGY
     YSEDDFFRLS DWMKGVFATE GAPIDGVYFC PTHPEHGIGR YKVESRFRKP NPGMILAAQH
     DFDLDLGASL LVGDKESDIQ AGSTAGVGTT LLICDRDASR VATAASAVVR NPRDVIPFLT
     GPGPDAGSF
//