ID   GMHA_BURMA     STANDARD;      PRT;   197 AA.
AC   Q9AI36; Q62HG3;
DT   28-FEB-2003 (Rel. 41, Created)
DT   01-FEB-2005 (Rel. 46, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Phosphoheptose isomerase (EC 5.3.1.-) (Sedoheptulose 7-phosphate
DE   isomerase).
GN   Name=gmhA; OrderedLocusNames=BMA2295;
OS   Burkholderia mallei (Pseudomonas mallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=13373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 23344;
RX   MEDLINE=21267073; PubMed=11373120; DOI=10.1006/mpat.2000.0430;
RA   DeShazer D., Waag D.M., Fritz D.L., Woods D.E.;
RT   "Identification of a Burkholderia mallei polysaccharide gene cluster
RT   by subtractive hybridization and demonstration that the encoded
RT   capsule is an essential virulence determinant.";
RL   Microb. Pathog. 30:253-269(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23344;
RX   PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA   Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA   Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M.,
RA   Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F.,
RA   Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M.,
RA   Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y.,
RA   Zafar N., Zhou L., Fraser C.M.;
RT   "Structural flexibility in the Burkholderia mallei genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
RN   [3]
RP   BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE.
RX   PubMed=12101286;
RA   Valvano M.A., Messner P., Kosma P.;
RT   "Novel pathways for biosynthesis of nucleotide-activated glycero-
RT   manno-heptose precursors of bacterial glycoproteins and cell surface
RT   polysaccharides.";
RL   Microbiology 148:1979-1989(2002).
CC   -!- FUNCTION: Catalyzes the isomerization of sedoheptulose 7-phosphate
CC       in D-glycero-D-manno-heptose 7-phosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: D-sedoheptulose 7-phosphate = D-glycero-alpha-
CC       D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-
CC       phosphate.
CC   -!- PATHWAY: Capsular polysaccharide (CPS) biosynthesis; GDP-D-
CC       glycero-alpha-D-manno-heptose biosynthesis; first step.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity).
CC   -!- SIMILARITY: Belongs to the SIS family. GmhA subfamily.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF285636; AAK26468.1; -.
DR   EMBL; CP000010; AAU49838.1; -.
DR   TIGR; BMA2295; -.
DR   HAMAP; MF_00067; -; 1.
DR   InterPro; IPR004515; GmhA.
DR   InterPro; IPR001347; SIS.
DR   Pfam; PF01380; SIS; 1.
DR   TIGRFAMs; TIGR00441; gmhA; 1.
KW   Bacterial capsule; Carbohydrate metabolism; Complete proteome;
KW   Isomerase.
FT   CONFLICT     26     26       D -> N (in Ref. 1).
SQ   SEQUENCE   197 AA;  20784 MW;  63A1B00CA5E440D4 CRC64;
     MENRELTYIT NSIAEAQRVM AAMLADERLL ATVQKVADAC IASIAQGGKV LLAGNGGSAA
     DAQHIAGEFV SRFAFDRPGL PAVALTTDTS ILTAIGNDYG YEKLFSRQVQ ALGNKGDVLI
     GYSTSGKSPN ILAAFREAKA KGMTCVGFTG NRGGEMRELC DLLLEVPSAD TPKIQEGHLV
     LGHIVCGLVE HSIFGKQ
//