ID   HLDD_BURPS     STANDARD;      PRT;   330 AA.
AC   Q9WWX6; Q63S12;
DT   01-FEB-2005 (Rel. 46, Created)
DT   01-FEB-2005 (Rel. 46, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (ADP-L-
DE   glycero-beta-D-manno-heptose-6-epimerase) (ADP-glyceromanno-heptose 6-
DE   epimerase) (ADP-hep 6-epimerase) (AGME).
GN   Name=hldD; Synonyms=gmhD; OrderedLocusNames=BPSL2509;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1026b;
RX   MEDLINE=20011168; PubMed=10543742;
RA   Burtnick M.N., Woods D.E.;
RT   "Isolation of polymyxin B-susceptible mutants of Burkholderia
RT   pseudomallei and molecular characterization of genetic loci involved
RT   in polymyxin B resistance.";
RL   Antimicrob. Agents Chemother. 43:2648-2656(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L.,
RA   Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R.,
RA   Brooks K., Brown K.A., Brown N.F., Challis G.L., Cherevach I.,
RA   Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D.,
RA   Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K.,
RA   Keith K.E., Maddison M., Moule S., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA   Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis,
RT   Burkholderia pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- FUNCTION: Catalyzes the interconversion between ADP-D-glycero-
CC       beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an
CC       epimerization at carbon 6 of the heptose (By similarity).
CC   -!- CATALYTIC ACTIVITY: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-
CC       D-manno-heptose.
CC   -!- COFACTOR: Binds 1 NADP(+) per subunit (By similarity).
CC   -!- SUBUNIT: Homopentamer (By similarity).
CC   -!- DOMAIN: Contains a large N-terminal NADP-binding domain, and a
CC       smaller C-terminal substrate-binding domain (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family. HldD subfamily.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF159428; AAD43346.1; -.
DR   EMBL; BX571965; CAH36516.1; -.
DR   HSSP; P17963; 1EQ2.
DR   HAMAP; MF_01601; -; 1.
KW   Carbohydrate metabolism; Complete proteome; Isomerase; NADP.
FT   NP_BIND       7     13       ADP (By similarity).
FT   ACT_SITE    116    116       By similarity.
FT   ACT_SITE    139    139       By similarity.
FT   ACT_SITE    143    143       By similarity.
FT   CONFLICT     64     64       G -> S (in Ref. 1).
FT   CONFLICT    242    242       T -> A (in Ref. 1).
FT   CONFLICT    302    302       T -> K (in Ref. 1).
SQ   SEQUENCE   330 AA;  37019 MW;  3DBF6A129000E524 CRC64;
     MTLIVTGAAG FIGANIVKAL NERGETRIIA VDNLTRADKF KNLVDCEIDD YLDKTEFVER
     FARGDFGKVR AVFHEGACSD TMETDGRYMM DNNFRYSRAV LDACLAQGTQ FLYASSAAIY
     GGSSRFVEAR EFEAPLNVYG YSKFLFDQVI RRVMPSAKSQ IAGFRYFNVY GPRESHKGRM
     ASVAFHNFNQ FRAEGKVKLF GEYNGYGPGE QTRDFVSVED VAKVNLHFFD HPQKSGIFNL
     GTGRAQPFND IATTVVNTLR ALEGQPALTL AEQVEQGLVE YVPFPDALRG KYQCFTQADQ
     TTLRAAGYDA PFLTVQEGVD RYVRWLFGQL
//