LOCUS BX842582 349563 bp DNA linear BCT 17-APR-2005 DEFINITION Mycobacterium tuberculosis H37Rv complete genome; segment 11/13. ACCESSION BX842582 AL009198 AL021646 AL021840 AL021841 AL123456 Z77165 Z83867 Z92771 Z95120 Z95121 Z95150 Z96070 VERSION BX842582.1 GI:38490319 KEYWORDS complete genome. SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C., Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III, Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T., Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S., Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J., Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A., Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J., Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and Barrell,B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393 (6685), 537-544 (1998) PUBMED 9634230 REFERENCE 2 AUTHORS Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148 (PT 10), 2967-2973 (2002) PUBMED 12368430 REFERENCE 3 (bases 1 to 349563) AUTHORS Parkhill,J. TITLE Direct Submission JOURNAL Submitted (11-JUN-1998) Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk COMMENT On or before Nov 21, 2003 this sequence version replaced gi:3242262, gi:3242278, gi:3261516, gi:3261517, gi:3261609, gi:3261695, gi:3242259, gi:3261739, gi:3261742, gi:3250708, gi:3261791. Notes: Details of M. tuberculosis sequencing at the Sanger Centre are available on the World Wide Web. (URL, http://www.sanger.ac.uk/Projects/M_tuberculosis/). FEATURES Location/Qualifiers source 1..349563 /organism="Mycobacterium tuberculosis H37Rv" /mol_type="genomic DNA" /strain="H37Rv" /db_xref="taxon:83332" gene complement(150..756) /gene="ssr" misc_RNA complement(150..756) /gene="ssr" /product="10Sa RNA" /note="ssr, len: 607 nt. Match to EM_BA:MT10SARNA X60301 M.tuberculosis gene for 10Sa RNA." /function="INVOLVED IN DEGRADATION OF PROTEINS ENCODED BY ABNORMAL MESSENGER RNA." gene complement(750..1601) /locus_tag="Rv3099c" CDS complement(750..1601) /locus_tag="Rv3099c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3099c, (MTCY164.10c), len: 283 aa. Conserved hypothetical protein, some similarity with hypothetical proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 384, E(): 1.8e-17, (32.7% identity in 269 aa overlap); and P71606|Y036_MYCTU|Rv0036c from Mycobacterium tuberculosis strain H37Rv (257 aa), FASTA scores: opt: 179, E(): 0.00024, (25.85% identity in 205 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08389.1" /db_xref="GI:2076674" /db_xref="UniProtKB/TrEMBL:O05777" /translation="MTTPGRPLTTLDKSDVLAGLFAVWHSLDALLDGLLETDWQATSP LPGWDVKAVVSHIIGTESFLLGIAAPEPDTDVSALAHVRNPIGVMNECWVRHLGTESG VGLLERFRAVTSQRRKVLASLSDDEWNAPTTTPSGPDSYGRFMRIRIFDCWMHEQDIR AAVQRPSSDDELGGPASPLVLDEIAATMGFVVGKLAKAPDGSRVLLELTGPLSRSIRV SVDGRARVVDDFGGPAPTATIRLDGLQFTRLAGGRPMSPARSQDVELGGDKELAGHIL ERLNFVI" gene complement(1638..2120) /gene="smpB" /locus_tag="Rv3100c" CDS complement(1638..2120) /gene="smpB" /locus_tag="Rv3100c" /function="BINDS SPECIFICALLY TO THE SSRA RNA (TMRNA) AND IS REQUIRED FOR STABLE ASSOCIATION OF SSRA WITH RIBOSOMES. THOUGHT TO BE IMPLICATED IN THE SURVIVAL OF BACTERIUM WITHIN MACROPHAGES." /note="Rv3100c, (MTCY164.11c), len: 160 aa. Probable smpB, small protein b related to several bacterial small protein b homologs e.g. O32881|SSRP_MYCLE|ML0671|MLCB1779.19c from Mycobacterium leprae (160 aa), FASTA scores: opt: 914, E(): 1.1e-52, (84.9% identity in 159 aa overlap); Q9L1S9|SMPB from Streptomyces coelicolor (159 aa), FASTA scores: opt: 568, E(): 3.3e-30, (55.15% identity in 145 aa overlap); O32230|SSRP_BACSU from Bacillus subtilis (156 aa), FASTA scores: opt: 511, E(): 1.7e-26, (47.05% identity in 153 aa overlap); etc. BELONGS TO THE SSRP FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE SSRA-BINDING PROTEIN SMPB" /protein_id="CAB08390.1" /db_xref="GI:2076675" /db_xref="GOA:P0A612" /db_xref="InterPro:IPR000037" /db_xref="UniProtKB/Swiss-Prot:P0A612" /translation="MSKSSRGGRQIVASNRKARHNYSIIEVFEAGVALQGTEVKSLRE GQASLADSFATIDDGEVWLRNAHIPEYRHGSWTNHEPRRNRKLLLHRRQIDTLVGKIR EGNFALVPLSLYFAEGKVKVELALARGKQARDKRQDMARRDAQREVLRELGRRAKGMT " gene complement(2123..3016) /gene="ftsX" /locus_tag="Rv3101c" CDS complement(2123..3016) /gene="ftsX" /locus_tag="Rv3101c" /function="INVOLVED IN GROWTH (PRINCIPALLY DURING LOG PHASE CELLS). THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF SEPTATION COMPONENT ACROSS THE MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. IS CODED IN AN OPERON ESSENTIAL FOR CELL DIVISION." /experiment="experimental evidence, no additional details recorded" /note="Rv3101c, (MTCY164.12c), len: 297 aa. Putative ftsX, cell division protein, septation component transport integral membrane protein ABC transporter (see citations below), equivalent to O32882|FTSX_MYCLE|ML0670|MLCB1779.20c CELL DIVISION PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1597, E(): 9.2e-93, (80.8% identity in 297 aa overlap); and similar to others e.g. Q9L1S7|SCE59.27c from Streptomyces coelicolor (305 aa), FASTA scores: opt: 585, E(): 1.9e-29, (34.55% identity in 304 aa overlap); O34876|FTSX_BACSU from Bacillus subtilis (296 aa), FASTA scores: opt: 318, E(): 9.1e-13, (24.65% identity in 300 aa overlap); Q9K6X3|FTSX|BH3601 from Bacillus halodurans (298 aa), FASTA scores: opt: 290, E(): 5.2e-11, (22.75% identity in 299 aa overlap); etc. BELONGS TO THE FTSX FAMILY." /codon_start=1 /transl_table=11 /product="PUTATIVE CELL DIVISION PROTEIN FTSX (SEPTATION COMPONENT-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER)" /protein_id="CAB08391.1" /db_xref="GI:2076676" /db_xref="GOA:P96293" /db_xref="InterPro:IPR003838" /db_xref="UniProtKB/Swiss-Prot:P96293" /translation="MRFGFLLNEVLTGFRRNVTMTIAMILTTAISVGLFGGGMLVVRL ADSSRAIYLDRVESQVFLTEDVSANDSSCDTTACKALREKIETRSDVKAVRFLNRQQA YDDAIRKFPQFKDVAGKDSFPASFIVKLENPEQHKDFDTAMKGQPGVLDVLNQKELID RLFAVLDGLSNAAFAVALVQAIGAILLIANMVQVAAYTRRTEIGIMRLVGASRWYTQL PFLVEAMLAATMGVGIAVAGLMVVRALFLENALNQFYQANLIAKVDYADILFITPWLL LLGVAMSGLTAYLTLRLYVRR" gene complement(3017..3706) /gene="ftsE" /locus_tag="Rv3102c" CDS complement(3017..3706) /gene="ftsE" /locus_tag="Rv3102c" /function="INVOLVED IN GROWTH. THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT OF SEPTATION COMPONENT ACROSS THE MEMBRANE. RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM. IS CODED IN AN OPERON ESSENTIAL FOR CELL DIVISION." /experiment="experimental evidence, no additional details recorded" /note="Rv3102c, (MTCY164.13_2c), len: 229 aa. Putative ftsE, cell division protein, septation component transport ATP-binding protein ABC transporter (see citations below), equivalent to O32883|FTSE|ML0669 CELL DIVISION ATP-BINDING PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1384, E(): 2.4e-74, (91.7% identity in 229 aa overlap); and similar to Q9L1S6|FTSE from Streptomyces coelicolor (229 aa), FASTA scores: opt: 914, E(): 8.7e-47, (62.85% identity in 226 aa overlap); Q9A0S4|FTSE|SPY0644 from Streptococcus pyogenes (230 aa), FASTA scores: opt: 866, E(): 5.7e-44, (57.9% identity in 228 aa overlap); Q9CGX0|FTSE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (230 aa), FASTA scores: opt: 792, E(): 1.3e-39, (52.2% identity in 228 aa overlap); etc. Other relatives from Mycobacterium tuberculosis include: MTCY253.24; MTCY16B7.10; MTCY9C4.04c; MTCY50.01; MTCY05A6.09c; MTCY04C12.31. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and ABC transporters family signature (PS00211). BELONG TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS)." /codon_start=1 /transl_table=11 /product="PUTATIVE CELL DIVISION ATP-BINDING PROTEIN FTSE (SEPTATION COMPONENT-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER)" /protein_id="CAB08392.1" /db_xref="GI:2076677" /db_xref="GOA:O05779" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="UniProtKB/TrEMBL:O05779" /translation="MITLDHVTKQYKSSARPALDDINVKIDKGEFVFLIGPSGSGKST FMRLLLAAETPTSGDVRVSKFHVNKLRGRHVPKLRQVIGCVFQDFRLLQQKTVYDNVA FALEVIGKRTDAINRVVPEVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVL LADEPTGNLDPETSRDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELSLGRLVR DEQRGVYGMDR" misc_feature complement(3248..3292) /gene="ftsE" /locus_tag="Rv3102c" /note="PS00211 ABC transporters family signature" misc_feature complement(3578..3601) /gene="ftsE" /locus_tag="Rv3102c" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene complement(3750..4187) /locus_tag="Rv3103c" CDS complement(3750..4187) /locus_tag="Rv3103c" /function="UNKNOWN" /note="Rv3103c, (MTCY164.13c), len: 145 aa. Hypothetical unknown pro-rich protein, with some similarity to Proline-rich proteins e.g. Q39789 PROLINE-RICH CELL WALL PROTEIN from Gossypium hirsutum (Upland cotton) (214 aa), FASTA scores: opt: 267, E(): 0.00014, (40% identity in 110 aa overlap). Equivalent to AAK47525 from M. mycobacterium strain CDC1551 (158 aa) but shorter 13 aa." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROLINE-RICH PROTEIN" /protein_id="CAB08393.1" /db_xref="GI:2076678" /db_xref="InterPro:IPR001412" /db_xref="UniProtKB/TrEMBL:O05780" /translation="MKLSNQKRHWPGYLFGRIRTSTLVLIAAFLAVWWIYETYRPQAP GPGDSPPTQVVPPGFVPDPDYTWVPRTRVQPPTVKATPTTTSSTPPVSPPETTTDSAV PPPFELPPPFGPGTTTPTPPAPLPQPGPGPTAGTYPKSEPPTR" gene complement(4189..5115) /locus_tag="Rv3104c" CDS complement(4189..5115) /locus_tag="Rv3104c" /function="UNKNOWN" /note="Rv3104c, (MTCY164.14c), len: 308 aa. Possible conserved transmembrane protein, with some similarity to hypthetical proteins e.g. Q9L1X9|SC8E4A.26 PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (408 aa), FASTA scores: opt: 514, E(): 4.3e-25, (35.2% identity in 287 aa overlap); Q9XA89|CF43A.26c HYPOTHETICAL 36.1 KDA PROTEIN from Streptomyces coelicolor (333 aa), FASTA scores: opt: 482, E(): 3.7e-23, (34.9% identity in 301 aa overlap); Q55987|SLR0765 HYPOTHETICAL 68.9 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (617 aa), FASTA scores: opt: 429, E(): 1.3e-19, (30.6% identity in 278 aa overlap); etc." /codon_start=1 /transl_table=11 /product="POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN" /protein_id="CAB08394.1" /db_xref="GI:2076679" /db_xref="GOA:O05781" /db_xref="InterPro:IPR006685" /db_xref="UniProtKB/TrEMBL:O05781" /translation="MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVL AARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEV IDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGS PENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADL GRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAG RQLRVLVIRALTRAGIVTAADARAAVAESPEQ" gene complement(5105..6241) /gene="prfB" /locus_tag="Rv3105c" CDS complement(5105..6241) /gene="prfB" /locus_tag="Rv3105c" /function="PEPTIDE CHAIN RELEASE FACTOR 2 DIRECTS THE TERMINATION OF TRANSLATION IN RESPONSE TO THE PEPTIDE CHAIN TERMINATION CODONS UGA AND UAA." /note="Rv3105c, (MTCY164.15c), len: 378 aa. Probable prfB, peptide chain release factor 2, equivalent to O32885|RF2_MYCLE|ML0667|MLCB1779.24c from Mycobacterium leprae, FASTA scores: opt: 2197, E(): 1.8e-126, (90.05% identity in 372 aa overlap); and also similar to other peptide chain release factors e.g. Q9L1S3|PRFB from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1674, E(): 1.2e-94, (69.3% identity in 365 aa overlap); O67695|RF2_AQUAE|PRFB|AQ_1840 from Aquifex aeolicus (373 aa), FASTA scores: opt: 1082, E(): 1.3e-58, (44.45% identity in 369 aa overlap); P28367|RF2_BACSU from B. subtilis (366 aa), FASTA scores: opt: 1030, E(): 1.9e-55, (44.0% identity in 359 aa overlap); etc. Also related to Q10605|MTCY373.19|RF1_MYCTU|Rv1299|MT1338 peptide chain release factor 1 (rf-1) (357 aa), FASTA scores: opt: 646, E(): 1.1e-34, (38.6% identity in 350 aa overlap). Contains prokaryotic-type class I peptide chain release factors signature (PS00745). BELONGS TO THE PROKARYOTIC AND MITOCHONDRIAL RELEASE FACTORS FAMILY. TBparse score is 0.888." /codon_start=1 /transl_table=11 /product="PROBABLE PEPTIDE CHAIN RELEASE FACTOR 2 PRFB (RF-2)" /protein_id="CAB08395.1" /db_xref="GI:2076680" /db_xref="GOA:P66026" /db_xref="UniProtKB/Swiss-Prot:P66026" /translation="MPVTLAAVDPDRQADIAALDCTLTTVERVLDVEGLRSRIEKLEH EASDPHLWDDQTRAQRVTSELSHTQGELRRVEELRRRLDDLPVLYELAAEEAGAAAAD AVAEADAELKSLRADIEATEVRTLLSGEYDEREALVTIRSGAGGVDAADWAEMLMRMY IRWAEQHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQ SRRQTSFAEVEVLPVVETTDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPS GIVVTCQNEKSQLQNKIAAMRVLQAKLLERKRLEERAELDALKADGGSSWGNQMRSYV LHPYQMVKDLRTEYEVGNPAAVLDGDLDGFLEAGIRWRNRRNDD" misc_feature complement(5435..5485) /gene="prfB" /locus_tag="Rv3105c" /note="PS00745 Prokaryotic-type class I peptide chain release factors signature" gene 6344..7714 /gene="fprA" /locus_tag="Rv3106" CDS 6344..7714 /gene="fprA" /locus_tag="Rv3106" /EC_number="1.18.1.2" /function="GENERATES OXIDIZED FERREDOXIN FROM FERREDOXIN [CATALYTIC ACTIVITY: REDUCED FERREDOXIN + NADP(+) = OXIDIZED FERREDOXIN + NADPH]." /experiment="experimental evidence, no additional details recorded" /note="Rv3106, (MTCY164.16), len: 456 aa. fprA, NADPH:adrenodoxin oxidoreductase (NADPH-ferredoxin reductase) (EC 1.18.1.2) (see citations below), equivalent to O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae (456 aa), FASTA scores: opt: 2505, E(): 1.2e-142, (81,05% identity in 459 aa overlap); also similar to other NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from Deinococcus radiodurans (479 aa), FASTA scores: opt: 1331, E(): 2.6e-72, (48.9% identity in 454 aa overlap); Q9RK35|SCF15.02 from Streptomyces coelicolor (454 aa), FASTA scores: opt: 1102, E(): 1.3e-58, (41.35% identity in 462 aa overlap); P82861 from Salvelinus fontinalis (Brook trout) (498 aa), FASTA scores: opt: 827, E(): 4e-42, (41.3% identity in 460 aa overlap); Q9V3T9|ADRO_DROME from Drosophila melanogaster (Fruit fly) (466 aa), FASTA scores: opt: 790, E(): 6.3e-40, (39.45% identity in 459 aa overlap); etc. Also similar to Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium tuberculosis strain H37Rv (575 aa), FASTA scores: opt: 894, E(): 4.4e-46, (42.05% identity in 459 aa overlap)." /codon_start=1 /transl_table=11 /product="NADPH:ADRENODOXIN OXIDOREDUCTASE FPRA (NADPH-FERREDOXIN REDUCTASE)" /protein_id="CAB08363.1" /db_xref="GI:2076681" /db_xref="GOA:O05783" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000759" /db_xref="UniProtKB/Swiss-Prot:O05783" /translation="MRPYYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELSERYDAVIY AVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPDLSGARAVVIGNGNVAL DVARILLTDPDVLARTDIADHALESLRPRGIQEVVIVGRRGPLQAAFTTLELRELADL DGVDVVIDPAELDGITDEDAAAVGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPI EIKGKRKVERIVLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPF DDQSGTIPNVGGRINGSPNEYVVGWIKRGPTGVIGTNKKDAQDTVDTLIKNLGNAKEG AECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFERAAGEPHGRPRVKLASLAEL LRIGLG" gene complement(7715..9298) /gene="agpS" /locus_tag="Rv3107c" CDS complement(7715..9298) /gene="agpS" /locus_tag="Rv3107c" /EC_number="2.5.1.26" /function="INVOLVED IN ETHER LIPID BIOSYNTHESIS [CATALYTIC ACTIVITY: 1-ACYL-GLYCERONE 3-PHOSPHATE + A LONG-CHAIN ALCOHOL = 1-ALKYL-GLYCERONE 3-PHOSPHATE + A LONG-CHAIN ACID ANION]." /note="Rv3107c, (MTCY164.17c), len: 527 aa. Possible agpS, alkyl-dihydroxyacetonephosphate synthase (EC 2.5.1.26), similar to others and some various enzymes e.g. AAK46595|MT2311 PUTATIVE ALKYL-DIHYDROXYACETONEPHOSPHATE SYNTHASE from Mycobacterium tuberculosis strain CDC1551 (529 aa), FASTA scores: opt: 1052, E(): 2.1e-58, (37.1% identity in 542 aa overlap); Q9RJ97|SCF91.28c PUTATIVE FLAVOPROTEIN from Streptomyces coelicolor (530 aa), FASTA scores: opt: 972, E(): 2.2e-53, (36.2% identity in 544 aa overlap); O96759|ADAS_DICDI ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE (EC 2.5.1.26) from Dictyostelium discoideum (Slime mold) (611 aa), FASTA scores: opt: 617, E(): 4.5e-31, (33.95% identity in 480 aa overlap); O97157|ADAS_TRYBB ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE from Trypanosoma brucei (613 aa), FASTA scores: opt: 567, E(): 6.2e-28, (29.15% identity in 521 aa overlap); etc. Also similar to O53525|Rv2251|MTV022.01 HYPOTHETICAL 49.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (475 aa), FASTA scores: opt: 1019, E(): 2.3e-56, (38.6% identity in 487 aa overlap). BELONGS TO THE FAD-BINDING OXIDOREDUCTASE/TRANSFERASE FAMILY 4. COFACTOR: FAD (BY SIMILARITY)." /codon_start=1 /transl_table=11 /product="POSSIBLE ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE AGPS (ALKYL-DHAP SYNTHASE) (ALKYLGLYCERONE-PHOSPHATE SYNTHASE)" /protein_id="CAB08364.1" /db_xref="GI:2076682" /db_xref="GOA:O05784" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR006094" /db_xref="UniProtKB/TrEMBL:O05784" /translation="MRSWWGWGTVEDALSDQETQALQSRVAALVSGHDLSDHPPPDLT ALGLAAPRVSPPASLAALCSSDLVDRAGHARGKAYRDIARNLQGQLDHLPDLIARPRS EQDVIDVLDWCAREGIAVIPYGGGSSVVGGVEPRFDEPVVTVDVTAMSAVLEIDRVSR AARIQAGAFGPSIEHQLRPHDLTLRHFPQSFGFSTLGGWLATRSGGHFATLYTHIDDL TESLRIVTPVGISESRRLPGSGAGPSPDRLFLGSEGTLGIITEAWMRLQHRPRWQVTV SVVFDDWAAAVAATRTIAQAGLYPANCRLLDPAEALLNAGTSVGGGLLVLAFESADHP IDPWLHRAVAITAEHGGTVTAQRSRGTTSDATEHNAAANWRSAFLRMPYQRDALVRRG VIAETFETACTWDGFDTLHAAVTDAARTAIWKVCGTGVVTCRFTHVYPDGPAPYYGIY AGGRWGSLDAQWDEIKAAVSEAISASGGTITHHHAVGRDHRAWYDRQRPDPFAAALRA AKSALDPAGILNPGVLLGR" gene 9397..9837 /locus_tag="Rv3108" CDS 9397..9837 /locus_tag="Rv3108" /function="UNKNOWN" /note="Rv3108, (MTCY164.18), len: 146 aa. Hypothetical unknown protein." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAB08365.1" /db_xref="GI:2076683" /db_xref="UniProtKB/TrEMBL:O05785" /translation="MTPNAASTGDSAKNTITGCCLITARALVARTRSISLPGMPFRMP ADYHNASSDEPTNRHPWPAPARCCRHEWRTMRRTNACDRRRFGLSLTIHEDACRIISV VPVVLEVRRAEPAHPATPYPEPLARCSRSPGLNESSHMSGRIPP" gene 9986..11065 /gene="moaA1" /locus_tag="Rv3109" CDS 9986..11065 /gene="moaA1" /locus_tag="Rv3109" /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS; INVOLVED IN THE BIOSYNTHESIS OF MOLYBDOPTERIN PRECURSOR Z FROM GUANOSINE." /standard_name="moaA" /note="Rv3109, (MTCY164.19), len: 359 aa. Probable moaA1, molybdenum cofactor biosynthesis protein, highly similar to others e.g. P39757|MOAA_BACSU|NARA|NARAB from Bacillus subtilis (341 aa), FASTA scores: opt: 810, E(): 6.2e-44, (39.75% identity in 327 aa overlap); O67929|MOAA_AQUAE|AQ_2183 from Aquifex aeolicus (320 aa), FASTA scores: opt: 794, E(): 6e-43, (40.55% identity in 323 aa overlap); Q9ZIM6|MOAA_STACA from Staphylococcus carnosus (340 aa), FASTA scores: opt: 783, E(): 3.2e-42, (38.65% identity in 326 aa overlap); etc. Also highly similar to O53143|MOAA3|MOA3_MYCTU|MT3427 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 3 from Mycobacterium tuberculosis strain F4 (378 aa), FASTA scores: opt: 1762, E(): 4.7e-104, (74.3% identity in 350 aa overlap); and similar to O53881|MOA2_MYCTU|MOAA2|Rv0869c|MT0892|MTV043.62 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A 2 from Mycobacterium tuberculosis strain H37Rv (360 aa), FASTA scores: opt: 657, E(): 3e-34, (36.55% identity in 309 aa overlap). BELONGS TO THE MOAA / NIFB / PQQE FAMILY. Note that previously known as moaA." /codon_start=1 /transl_table=11 /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1" /protein_id="CAE55548.1" /db_xref="GI:38490320" /db_xref="GOA:O05786" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="UniProtKB/Swiss-Prot:O05786" /translation="MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYC MPEEHYTWLPRQDLLSVKEISAIVDVFLSVGVSKVRITGGEPLIRPDLPEIVRTLSAK VGEDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVSLDTLQPERFKAISQRNSHDKV IAGIKAVAAAGFTDTKIDTTVMRGANHDELADLIEFARTVNAEVRFIEYMDVGGATHW AWEKVFTKANMLESLEKRYGRIEPLPKHDTAPANRYALPDGTTFGIIASTTEPFCATC DRSRLTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQ RERGVFLPLSTLKADPHLEMHTRGG" gene 11116..11511 /gene="moaB1" /locus_tag="Rv3110" CDS 11116..11511 /gene="moaB1" /locus_tag="Rv3110" /EC_number="4.2.1.96" /function="THOUGHT TO BE INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS. CATALYZES THE DEHYDRATATION OF 4A-HYDROXYTETRAHYDROPTERINS [CATALYTIC ACTIVITY: (6R)-6-(L-ERYTHRO-1,2-DIHYDROXYPROPYL)-5,6,7,8-TETRAHYDRO -4 A-HYDROXYPTERIN = (6R)-6-(L-ERYTHRO-1,2- DIHYDROXYPROPYL)-7,8-DIHYDRO-6H-PTERIN + H(2)O]." /standard_name="moaB" /note="Rv3110, (MTCY164.20), len: 131 aa. Probable moaB1, pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), similar to others e.g. P73790|SSL2296 from Synechocystis sp. strain PCC 6803 (96 aa), FASTA scores: opt: 195, E(): 6.2e-07, (35.4% identity in 96 aa overlap); Q9PAB4|PHS_XYLFA|XF2604 from Xylella fastidiosa (116 aa), FASTA scores: opt: 187, E(): 2.6e-06, (36.25% identity in 102 aa overlap); AAK42360|Q97WM6|PHS_SULSO|SSO2187 from Sulfolobus solfataricus (114 aa), FASTA scores: opt: 177, E(): 1.3e-05, (34.6% identity in 78 aa overlap); etc. Also highly similar to AAK47768|MT3426 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis CDC1551 (124 aa), FASTA scores: opt: 383, E(): 7.7e-20, (50.0% identity in 110 aa overlap). BELONGS TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE FAMILY. Note that previously known as moaB." /codon_start=1 /transl_table=11 /product="PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB1 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD)" /protein_id="CAE55549.1" /db_xref="GI:38490321" /db_xref="GOA:Q6MX13" /db_xref="InterPro:IPR001533" /db_xref="UniProtKB/TrEMBL:Q6MX13" /translation="MTVSTPEQHEQRASHDASEGKHNVCQGRLAALADAAVSEKLGAL PGWQLLDMRLSRAFQCTNFDQSIDFMNRVASIANDINHHPDIAVLDKRSVRVTAWTRK LGYLTDIDFDLAASVEAMYATEFADRPAR" gene 11508..12020 /gene="moaC1" /locus_tag="Rv3111" CDS 11508..12020 /gene="moaC1" /locus_tag="Rv3111" /function="INVOLVED IN THE BIOSYNTHESIS OF MOLYBDOPTERIN." /standard_name="moaC" /note="Rv3111, (MTCY164.21), len: 170 aa. Probable moaC1, molybdopterin cofactor biosynthesis protein, highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa), FASTA scores: opt: 576, E(): 2.2e-29, (62.1% identity in 153 aa overlap); Q9ZFA6|MOAC from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (159 aa), FASTA scores: opt: 541, E(): 3.4e-27, (59.85% identity in 157 aa overlap); BAB48171|MLR0616 from Rhizobium loti (Mesorhizobium loti) (160 aa), FASTA scores: opt: 531, E(): 1.5e-26, (58.75% identity in 160 aa overlap); P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa), FASTA scores: opt: 527, E(): 2.6e-26, (58.5% identity in 159 aa overlap); etc. Also highly similar to O53376|MOAC3|Rv3324c|MTV016.24c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 3 from Mycobacterium tuberculosis (177 aa), FASTA scores: opt: 738, E(): 1.7e-39, (71.5% identity in 165 aa overlap); AAK47767|MT3425 MOLYBDOPTERIN COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis strain CDC1551 (184 aa), FASTA scores: opt: 734, E(): 3.1e-39, (71.8% identity in 163 aa overlap); and Rv0864|MOAC2|MTV043.57 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 2 (167 aa). Note that previously known as moaC." /codon_start=1 /transl_table=11 /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C MOAC1" /protein_id="CAE55550.1" /db_xref="GI:38490322" /db_xref="GOA:P0A5K4" /db_xref="InterPro:IPR002820" /db_xref="UniProtKB/Swiss-Prot:P0A5K4" /translation="MIDHALALTHIDERGAARMVDVSEKPVTLRVAKASGLVIMKPST LRMISDGAAAKGDVMAAARIAGIAAAKRTGDLIPLCHPLGLDAVSVTITPCEPDRVKI LATTTTLGRTGVEMEALTAVSVAALTIYDMCKAVDRAMEISQIVLQEKSGGRSGVYRR SASDLACQSR" gene 12037..12288 /gene="moaD1" /locus_tag="Rv3112" CDS 12037..12288 /gene="moaD1" /locus_tag="Rv3112" /function="INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS." /standard_name="moaD" /note="Rv3112, (MTCY164.22), len: 83 aa. Probable moaD1, molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to others e.g. Q9HJF0|TA1019 from Thermoplasma acidophilum (85 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); BAB59710|TVG0556526 from Thermoplasma volcanium (90 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7% identity in 82 aa overlap); P30748|MOAD_ECOLI|CHLA4|CHLM|B0784 from Escherichia coli strain K12 (81 aa), FASTA scores: opt: 116, E(): 0.11, (36.9% identity in 84 aa overlap); etc. N-terminus also highly similar to to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 333, E(): 2e-16, (65.05% identity in 83 aa overlap); and some similarity with Rv0868c|MTV043.61c|MOAD2 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D 2 (92 aa). Note that previously known as moaD." /codon_start=1 /transl_table=11 /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D MOAD1 (MOLYBDOPTERIN CONVERTING FACTOR SMALL SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 1)" /protein_id="CAE55551.1" /db_xref="GI:38490323" /db_xref="GOA:Q7D640" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="UniProtKB/TrEMBL:Q7D640" /translation="MIKVNVLYFGAVREACDETPREEVEVQNGTDVGNLVDQLQQKYP RLRDHCQRVQMAVNQFIAPLSTVLGDGDEVAFIPQVAGG" gene 12411..13079 /locus_tag="Rv3113" CDS 12411..13079 /locus_tag="Rv3113" /EC_number="3.1.3.-" /function="UNKNOWN" /note="Rv3113, (MTCY164.23), len: 222 aa. Possible phosphatase (EC 3.1.3.-), with weak similarity to other phosphatases e.g. Q9KYY0|SCE33.02c from Streptomyces coelicolor (223 aa), FASTA scores: opt: 368, E(): 1.2e-16, (32.9% identity in 222 aa overlap); and Q55039|GPH_SYNP7|CBBZ PHOSPHOGLYCOLATE PHOSPHATASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (212 aa), FASTA scores: opt: 176, E(): 0.00025, (24.7% identity in 182 aa overlap)." /codon_start=1 /transl_table=11 /product="POSSIBLE PHOSPHATASE" /protein_id="CAB08370.1" /db_xref="GI:2076688" /db_xref="GOA:O05790" /db_xref="InterPro:IPR005834" /db_xref="InterPro:IPR006439" /db_xref="UniProtKB/TrEMBL:O05790" /translation="MTSRDGFTIVWDWNGTLCDDRTILLDAVGQTLVNEGFEPLSQQQ LIQRFARPLRTFFENACGRDLLTSEWERVQSTFRRIYRSREAEVTLVEDAYDVLAQGN RSAAGQFLLSLAPHDELMHFVQKYGIAKWFNGIRGRTRPDQEKPMMLAELIMQRSLNP TRVVHIGDSLEDAAAASAVGAISVLVTGASLQPPDRVMLKQLQPFVASSLKQALQYAG GDGD" gene 13096..13626 /locus_tag="Rv3114" CDS 13096..13626 /locus_tag="Rv3114" /function="UNKNOWN" /note="Rv3114, (MTCY164.24), len: 176 aa. Conserved hypothetical protein, with some similarity to Q9F9W7 CYTOSINE DEAMINASE from Bifidobacterium longum (143 aa), FASTA scores: opt: 207, E(): 2.2e-07, (37.05% identity in 108 aa overlap); and Q9RV23|DR1207 CELL CYCLE PROTEIN MESJ, PUTATIVE/CYTOSINE DEAMINASE-RELATED PROTEIN from Deinococcus radiodurans (600 aa), FASTA scores: opt: 212, E(): 3.5e-07, (33.35% identity in 177 aa overlap). Equivalent to AAK47536|MT3196 CYTIDINE AND DEOXYCYTIDYLATE DEAMINASE FAMILY PROTEIN from Mycobacterium tuberculosis strain CDC1551 (187 aa) but shorter 11 aa." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08371.1" /db_xref="GI:2076689" /db_xref="GOA:O05791" /db_xref="InterPro:IPR002125" /db_xref="UniProtKB/TrEMBL:O05791" /translation="MVAARLPFGWSADSGVTADIIEAAMELAIDTARHATAPFGAALL DVTTLRAFSGGNTYFESGDRFAHAETNVLRAAMSTLPELSNHVLISTAEPCPMCAAAS VLSGVRAIIFGTSIETLIQCGWFQIRISASDVVAASTRPTRPSVYSGFLSHKTDLLYR NSENRRAMNPWTDPSH" repeat_region 13736..15059 /note="IS1081-6, len: 1324 bp. Insertion sequence IS1081." /insertion_seq="IS1081-6" repeat_unit 13736..13750 /note="15 bp inverted repeat at left end of IS1081: TCGCGTGATCCTTCG" gene 13788..15035 /locus_tag="Rv3115" CDS 13788..15035 /locus_tag="Rv3115" /function="INVOLVED IN THE TRANSPOSITION IN THE INSERTION SEQUENCE IS1081." /experiment="experimental evidence, no additional details recorded" /note="Rv3115, (MTCY164.25), len: 415 aa. Probable IS1081 transposase, similar to others. Has transposases, mutator family, signature (PS01007). Other copies are MTCY10G2.02c, MTCY441.35, MTCY77.03c. TBparse score is 0.894." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAB08372.1" /db_xref="GI:2076690" /db_xref="GOA:P96354" /db_xref="InterPro:IPR001207" /db_xref="InterPro:IPR002016" /db_xref="UniProtKB/TrEMBL:P96354" /translation="MTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADAL CGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERA LTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGP YTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRD LVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRT LLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIW SNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRA RAALTSTEEPAKQQTTNTPALTT" misc_feature 14484..14558 /locus_tag="Rv3115" /note="PS01007 Transposases, Mutator family, signature" repeat_unit complement(15045..15059) /note="15 bp inverted repeat at right end of IS1081: TCGCGTGATCCTTCG" gene 15113..16282 /gene="moeB2" /locus_tag="Rv3116" CDS 15113..16282 /gene="moeB2" /locus_tag="Rv3116" /function="POSSIBLY INVOLVED IN MOLYBDOPTERIN METABOLISM (SYNTHESIS)." /standard_name="moeB" /note="Rv3116, (MTCY164.26), len: 389 aa. Probable moeB2, molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 1433, E(): 8e-80, (57.8% identity in 384 aa overlap). Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1562, E(): 1.1e-87, (58.15% identity in 380 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1311, E(): 2.1e-72, (52.4% identity in 395 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1238, E(): 5.7e-68, (51.4% identity in 393 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1212, E(): 2.2e-66, (46.5% identity in 398 aa overlap); etc. Also highly similar to O05860|MTCY07D11.20|MOEB1|Rv3206c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis strain H37Rv (392 aa), FASTA scores: opt: 1445, E(): 1.5e-80, (56.25% identity in 400 aa overlap). BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeB." /codon_start=1 /transl_table=11 /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB2 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE)" /protein_id="CAE55552.1" /db_xref="GI:38490324" /db_xref="GOA:Q7D637" /db_xref="InterPro:IPR000205" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR007901" /db_xref="UniProtKB/TrEMBL:Q7D637" /translation="MTEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARV LCIGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPKVESAAE AVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYV WGSIYRFNGQTSVFWPGRGPCYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTE VLKLLTGVGTPLVGRLLMYEALDATYHQIRIAKNPDCAICGDAPTITELVDDSVSCAS TQSVDPELVISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGL AQLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSSLLVY" gene 16311..17144 /gene="cysA3" /locus_tag="Rv3117" CDS 16311..17144 /gene="cysA3" /locus_tag="Rv3117" /EC_number="2.8.1.1" /function="MAY BE A SULFOTRANSFERASE INVOLVED IN THE FORMATION OF THIOSULFATE [CATALYTIC ACTIVITY: THIOSULFATE + CYANIDE = SULFITE + THIOCYANATE]." /standard_name="sseC3" /experiment="experimental evidence, no additional details recorded" /note="Rv3117, (MTCY164.27, MT3199, O05793), len: 277 aa. Probable cysA3 (alternate gene name: sseC3), thiosulfate sulfurtransferase (EC 2.8.1.1) (see Wooff et al., 2002), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE PUTATIVE SULFURTRANSFERASE THIOSULFATE from Mycobacterium leprae (277 aa). Also highly similar to other putative thiosulfate sulfurtransferases e.g. P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1442, E(): 1.7e-84, (75.55% identity in 274 aa overlap); Q9RXT9DR0217|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1046, E(): 2.6e-59, (53.8% identity in 275 aa overlap); Q9HMT7|TSSA|VNG2393G from Halobacterium sp. strain NRC-1 (293 aa), FASTA scores: opt: 1030, E(): 2.7e-58, (56.1% identity in 278 aa overlap); Q9Y8N8|APE2595 from Aeropyrum pernix (218 aa), FASTA scores: opt: 808, E(): 2.7e-44, (53.5% identity in 215 aa overlap); etc. Identical second copy present as Rv0815c|AL022004|MTV043.07c|MT0837|O05793|cysA2 (277 aa) (100.0% identity in 277 aa overlap). Also shows some similarity to P96888|THT2_MYCTU|SSEA|Rv3283|MT3382|MTCY71.23 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (297 aa), FASTA scores: opt: 955, E(): 1.6e-53, (50.2% identity in 271 aa overlap); and Q59570|THT3_MYCTU|SSEB|Rv2291|MT2348|MTCY339.19c PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium tuberculosis (284 aa), FASTA scores: E(): 1.4e-14, (26.7% identity in 292 aa overlap). Contains rhodanese active site and C-terminal signatures (PS00380, PS00683). BELONGS TO THE RHODANESE FAMILY. TBparse score is 0.901." /codon_start=1 /transl_table=11 /product="PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA3 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)" /protein_id="CAB08374.1" /db_xref="GI:2076692" /db_xref="GOA:O05793" /db_xref="InterPro:IPR001307" /db_xref="InterPro:IPR001763" /db_xref="UniProtKB/Swiss-Prot:O05793" /translation="MARCDVLVSADWAESNLHAPKVVFVEVDEDTSAYDRDHIAGAIK LDWRTDLQDPVKRDFVDAQQFSKLLSERGIANEDTVILYGGNNNWFAAYAYWYFKLYG HEKVKLLDGGRKKWELDGRPLSSDPVSRPVTSYTASPPDNTIRAFRDEVLAAINVKNL IDVRSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSRAANEDGTFKSDEELAKLY ADAGLDNSKETIAYCRIGERSSHTWFVLRELLGHQNVKNYDGSWTEYGSLVGAPIELG S" misc_feature 16935..17027 /gene="cysA3" /locus_tag="Rv3117" /note="PS00380 Rhodanese active site" misc_feature 17082..17105 /gene="cysA3" /locus_tag="Rv3117" /note="PS00683 Rhodanese C-terminal signature" gene 17146..17448 /gene="sseC1" /locus_tag="Rv3118" CDS 17146..17448 /gene="sseC1" /locus_tag="Rv3118" /function="THOUGHT TO BE INVOLVED IN SULPHUR METABOLISM." /standard_name="sseC" /note="Rv3118, (MTCY164.28, O05794), len: 100 aa. sseC1, conserved hypothetical protein, equivalent to Q9CBC7|ML2199 HYPOTHETICAL PROTEIN from Mycobacterium leprae (100 aa), FASTA scores: opt: 545, E(): 3.1e-30, (84.0% identity in 10 aa overlap). Also similar to hypothetical proteins e.g. Q50035 from Saccharopolyspora erythraea (Streptomyces erythraeus) (101 aa), FASTA scores: opt: 345, E(): 9.7e-17, (57.15% identity in 98 aa overlap); and Q9K4H3|SCD66.02 from Streptomyces coelicolor (95 aa), FASTA scores: opt: 249, E(): 2.8e-10, (48.5% identity in 99 aa overlap). Some weak similarity with Q9ZB84|PCAG PROTOCATECHUATE 3,4-DIOXYGENASE ALPHA-SUBUNIT from Pseudomonas marginata (196 aa), FASTA scores: opt: 109, E(): 1.4, (31.3% identity in 83 aa overlap); and other bacterial proteins. Identical second copy present as Rv0814c|AL022004|MTV043.06c|SSEC2 from Mycobacterium tuberculosis (100 aa) (100.0% identity in 100 aa overlap). Note that previously known as sseC." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN SSEC1" /protein_id="CAE55553.1" /db_xref="GI:38490325" /db_xref="GOA:Q7D986" /db_xref="InterPro:IPR000627" /db_xref="InterPro:IPR010814" /db_xref="UniProtKB/TrEMBL:Q7D986" /translation="MCSGPKQGLTLPASVDLEKETVITGRVVDGDGQAVGGAFVRLLD SSDEFTAEVVASATGDFRFFAAPGSWTLRALSAAGNGDAVVQPSGAGIHEVDVKIT" gene 17469..17912 /gene="moaE1" /locus_tag="Rv3119" CDS 17469..17912 /gene="moaE1" /locus_tag="Rv3119" /function="POSSIBLY A MOLYBDENUM BIOSYNTHESIS COFACTOR. CONVERSION OF MOLYBDOPTERIN PRECURSOR Z INTO MOLYBDOPTERIN REQUIRES TRANSFER OF TWO SULFUR ATOMS TO PRECURSOR Z (TO GENERATE THE DITHIOLENE GROUP). THIS IS CATALYZED BY THE CONVERTING FACTOR COMPOSED OF A SMALL AND LARGE SUBUNIT." /standard_name="moaE" /note="Rv3119, (MTCY164.29), len: 147 aa. Probable moaE1, molybdopterin converting factor E (molybdopterin converting factor (subunit 2)), highly similar to others e.g. O31705|MOAE from Bacillus subtilis (157 aa), FASTA scores: opt: 390, E(): 8.6e-19, (43.95% identity in 132 aa overlap); Q9K8I7|MOAE|BH3019 from Bacillus halodurans (156 aa), FASTA scores: opt: 369, E(): 2e-17, (42.4% identity in 132 aa overlap); P30749|MOAE_ECOLI|CHLA5|B0785 from Escherichia coli strain K12 (149 aa), FASTA scores: opt: 312, E(): 1.1e-13, (38.45% identity in 130 aa overlap); etc. Also highly similar (but shorter 74 aa) to O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE FUSION PROTEIN from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 733, E(): 3.9e-41, (76.2% identity in 143 aa overlap); and highly similar to O53878|MOAE2|Rv0866|MTV043.59 PUTATIVE MOLYBDOPTERIN SYNTHASE LARGE SUBUNIT from Mycobacterium tuberculosis (141 aa), FASTA scores: opt: 321, E(): 2.6e-14, (40.9% identity in 132 aa overlap). Note that previously known as moaE." /codon_start=1 /transl_table=11 /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E MOAE1 (MOLYBDOPTERIN CONVERTING FACTOR LARGE SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 2)" /protein_id="CAE55554.1" /db_xref="GI:38490326" /db_xref="GOA:O05795" /db_xref="InterPro:IPR003448" /db_xref="UniProtKB/Swiss-Prot:O05795" /translation="MANVVAEGAYPYCRLTDQPLSVDEVLAAVSGPEQGGIVIFVGNV RDHNAGHDVTRLFYEAYPPMVIRTLMSIIGRCEDKAEGVRVAVAHRTGELQIGDAAVV IGASAPHRAEAFDAARMCIELLKQEVPIWKKEFSSTGAEWVGDRP" gene 17909..18511 /locus_tag="Rv3120" CDS 17909..18511 /locus_tag="Rv3120" /function="UNKNOWN" /note="Rv3120, (MTCY164.30), len: 200 aa. Conserved hypothetical protein, with weak similarity to several hypothetical proteins and many N-methyl transferases e.g. Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor A3(2) (208 aa), FASTA scores: opt: 177, E(): 0.00011, (34.6% identity in 130 aa overlap); Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 147, E(): 0.011, (31.3% identity in 166 aa overlap); BAB52127|MLL5735 PROBABLE METHYLTRANSFERASE from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 133, E(): 0.11, (29.75% identity in 158 aa overlap). Highly similar to O53374|Rv3322c|MTV016.22c POSSIBLE METHYLTRANSFERASE from Mycobacterium tuberculosis strain H37Rv (204 aa), FASTA scores: opt: 691, E(): 1.1e-38, (57.0% identity in 200 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08377.1" /db_xref="GI:2076695" /db_xref="GOA:O05796" /db_xref="InterPro:IPR000051" /db_xref="UniProtKB/TrEMBL:O05796" /translation="MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQF GVPEGPVLELACGRSGTALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVH ADLCSWQSGDGRFALVLCRLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRA EWCLKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL" gene 18846..20048 /gene="cyp141" /locus_tag="Rv3121" CDS 18846..20048 /gene="cyp141" /locus_tag="Rv3121" /EC_number="1.14.-.-" /function="CYTOCHROMES P450 ARE A GROUP OF HEME-THIOLATE MONOOXYGENASES. THEY OXIDIZE A VARIETY OF STRUCTURALLY UNRELATED COMPOUNDS, INCLUDING STEROIDS, FATTY ACIDS, AND XENOBIOTICS." /note="Rv3121, (MTCY164.31), len: 400 aa. Probable cyp141, cytochrome P-450 integral membrane protein (EC 1.14.-.-), similar to other cytochrome P450-dependent oxidases e.g. Q9X5P9|CYP107N1 from Streptomyces lavendulae (410 aa), FASTA scores: opt: 825, E(): 3.1e-42, (33.35% identity in 393 aa overlap); Q59819|OLEP|CYP107D1 from Streptomyces antibioticus (407 aa), FASTA scores: opt: 812, E(): 1.9e-41, (34.85% identity in 396 aa overlap); O32460|CYP107M1 from Actinomadura hibisca (411 aa), FASTA scores: opt: 713, E(): 1.6e-35, (31.05% identity in 396 aa overlap); P55544|CPXP_RHISN|CYP112A|Y4LD from Rhizobium sp. strain NGR234 (400 aa), FASTA scores: opt: 688, E(): 5.1e-34, (33.0% identity in 406 aa overlap); etc. Also similar to MTCY339.44c, MTCY369.22, MTCY50.26, MTCY03C7.11, MTCY339.34c, MTCY339.42, MTCY369.11c. Contains cytochrome P450 cysteine heme-iron ligand signature (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE CYTOCHROME P450 141 CYP141" /protein_id="CAB08378.1" /db_xref="GI:2076696" /db_xref="GOA:O08362" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="UniProtKB/Swiss-Prot:O08362" /translation="MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAW LVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQG LNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVH ELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQS TMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIV RFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPN EHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIK ELLVTWPT" misc_feature 19860..19889 /gene="cyp141" /locus_tag="Rv3121" /note="PS00086 Cytochrome P450 cysteine heme-iron ligand signature" gene 20426..20896 /locus_tag="Rv3122" CDS 20426..20896 /locus_tag="Rv3122" /function="UNKNOWN" /note="Rv3122, (MTCY164.32), len: 156 aa. Hypothetical unknown protein." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAB08379.1" /db_xref="GI:2094816" /db_xref="UniProtKB/TrEMBL:O07033" /translation="MYSGCWINNQNGETRVGEDSLEDLEQRRARLYDQLAATGDFRRG SISENYRRCGKPNCVCAQEGHPGHGPRYLWTRTVAGRGTKGRQLSVEEVDKVRAELAN YHRFAQVSEQIVAVNEAICEARPPNPAATAPPAGTTGHKKGGSATRSRRSSPPR" gene 20906..21400 /locus_tag="Rv3123" CDS 20906..21400 /locus_tag="Rv3123" /function="UNKNOWN" /note="Rv3123, (MTCY164.33), len: 162 aa. Hypothetical unknown protein, but N-terminus shares weak similarity with N-terminal part of O93439|CMESO-1 BHLH TRANSCRIPTION FACTOR from Gallus gallus (Chicken) (287 aa), FASTA scores: opt: 129, E(): 0.81, (38.75% identity in 80 aa overlap)." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAB08380.1" /db_xref="GI:2094817" /db_xref="UniProtKB/TrEMBL:O07034" /translation="MRSRSVRWDPRCRPGRSGVGDPHCDDPAGLLAAGAAAGRRHRAP GPAHRLRARALRVVRRLPRQEPRYRAGPGPVAPRLLPLPHLRAWDGAPWIWNLATAIL PEATPIVDLYHARQHVHDLAGQLAPALGEHHSDWLTARLVDLDSGDIETLVQQPIGQH TGHT" gene 21843..22712 /locus_tag="Rv3124" CDS 21843..22712 /locus_tag="Rv3124" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /note="Rv3124, (MTCY164.34), len: 289 aa. Probable transcriptional regulatory protein, similar to many Streptomyces and Mycobacterium tuberculosis regulatory proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15 from Mycobacterium tuberculosis strain H37Rv (388 aa), FASTA scores: opt: 963, E(): 2e-56, (55.15% identity in 252 aa overlap); O53145 from Mycobacterium tuberculosis (381 aa); P71484|EMBR from Mycobacterium avium (384 aa), FASTA scores: opt: 859, E(): 1.5e-49, (52.2% identity in 249 aa overlap); Q9XCC3|TYLT from Streptomyces fradiae (404 aa), FASTA scores: opt: 462, E(): 3.1e-23, (35.05% identity in 254 aa overlap); Q9XCC4|TYLS from Streptomyces fradiae (277 aa), FASTA scores: opt: 456, E(): 5.6e-23, (33.45% identity in 269 aa overlap); etc. Start chosen by similarity, alternative possible (see AAK47548 from Mycobacterium tuberculosis strain CDC1551, longer N-terminus (311 aa))." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN" /protein_id="CAB08381.1" /db_xref="GI:2076697" /db_xref="GOA:O05797" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR005158" /db_xref="InterPro:IPR011991" /db_xref="UniProtKB/TrEMBL:O05797" /translation="MQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQVVAADA LVQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDRQQCD LDRFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALTED ELLVHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDA YHRLKSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEEL TESDKDLLPIGLA" gene complement(22813..23988) /gene="PPE49" /locus_tag="Rv3125c" CDS complement(22813..23988) /gene="PPE49" /locus_tag="Rv3125c" /function="UNKNOWN" /note="Rv3125c, (MTCY164.35c), len: 391 aa. Member of the Mycobacterium tuberculosis PPE family, similar to other e.g. P95247|Rv2352c|MTCY98.21c (391 aa), FASTA scores: opt: 1576, E(): 3.8e-72, (62.55% identity in 398 aa overlap), MTCY98.0029c, MTCY03A2.22c, MTCY10G2.10, MTCY02B10.25c, MTCI364.08, M TCY21C12.09c, MTCY48.17." /codon_start=1 /transl_table=11 /product="PPE FAMILY PROTEIN" /protein_id="CAE55555.1" /db_xref="GI:38490327" /db_xref="InterPro:IPR000030" /db_xref="UniProtKB/TrEMBL:Q7D631" /translation="MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWASA SSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQARAAATAFEAA LAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDYLEMWAQDVAAMVGYHAGA KSVAATLAPFSLPPVSLAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQ SLVSQLPLQHASMLFLPVRILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAA IPAFKPLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPV ALTQAAGAAGGGMPMMLMPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG" gene complement(24145..24459) /locus_tag="Rv3126c" CDS complement(24145..24459) /locus_tag="Rv3126c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3126c, (MTCY164.36c), unknown, len: 104 aa. Hypothetical unknown protein. Shortened version of MTCY164.36c, avoiding overlap." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAB08398.1" /db_xref="GI:3250711" /db_xref="UniProtKB/TrEMBL:O05799" /translation="MVIRFDQIGSLVLSMKSLASLSFQRCLRENSSLVAALDRLDAAV DELSALSFDALTTPERDRARRDRDHHPWSRSRSQLSPRMAHGAVHQCQWPKAVWAVID NP" gene 24484..25518 /locus_tag="Rv3127" CDS 24484..25518 /locus_tag="Rv3127" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3127, (MTCY164.37), len: 344 aa. Hypothetical protein, highly similar to Mycobacterium tuberculosis protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 1212, E(): 6e-69, (56.7% identity in 321 aa overlap), and also similar to P95195|MTCY03A2.27c (332 aa), FASTA scores: opt: 521, E(): 1.6e-25; (35.0% identity in 326 aa overlap). Some similarity to C-terminal half of hypothetical Mycobacterium tuberculosis proteins." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08361.1" /db_xref="GI:2076700" /db_xref="UniProtKB/TrEMBL:O05800" /translation="MLKNAVLLACRAPSVHNSQPWRWVAESGSEHTTVHLFVNRHRTV PATDHSGRQAIISCGAVLDHLRIAMTAAHWQANITRFPQPNQPDQLATVEFSPIDHVT AGQRNRAQAILQRRTDRLPFDSPMYWHLFEPALRDAVDKDVAMLDVVSDDQRTRLVVA SQLSEVLRRDDPYYHAELEWWTSPFVLAHGVPPDTLASDAERLRVDLGRDFPVRSYQN RRAELADDRSKVLVLSTPSDTRADALRCGEVLSTILLECTMAGMATCTLTHLIESSDS RDIVRGLTRQRGEPQALIRVGIAPPLAAVPAPTPRRPLDSVLQIRQTPEKGRNASDRN ARETGWFSPP" gene complement(25505..26518) /locus_tag="Rv3128c" /pseudo CDS complement(25505..26518) /locus_tag="Rv3128c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3128c, (MTCY164.38c), len: 337 aa. Conserved hypothetical protein, similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon but is similar throughout its length to Rv2807|MTCY16B7.36c|Z81331 CONSERVED HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (384 aa), FASTA scores: opt: 954, E(): 0, (47.2% identity in 339 aa overlap)." /pseudo /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" gene 26997..27329 /locus_tag="Rv3129" CDS 26997..27329 /locus_tag="Rv3129" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3129, (MTCY164.40), len: 110 aa. Conserved hypothetical protein, with some similarity to various hypothetical proteins from Streptomyces coelicolor e.g. Q9RI34|SCJ12.26 HYPOTHETICAL 14.5 KDA PROTEIN (137 aa), FASTA scores: opt: 141, E(): 0.0016, (39.3% identity in 84 aa overlap); Q9RI49|SCJ12.09c HYPOTHETICAL 15.8 KDA PROTEIN (146 aa), FASTA scores: opt: 141, E(): 0.0017, (38.05% identity in 92 aa overlap); Q9RJ05|SCJ1.09C POSSIBLE DNA-BINDING PROTEIN (233 aa), FASTA scores: opt: 140, E(): 0.0029, (34.85% identity in 89 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT (334 aa); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAE55557.1" /db_xref="GI:38490328" /db_xref="UniProtKB/TrEMBL:Q7D628" /translation="MVQGRTVLFRTAEGAKLFSAVAKCAVAFEADDHNVAEGWSVIVK VRAQVLTTDAGVREAERAQLLPWTATLKRHCVRVIPWEITGRHFRFGPEPDRSQTFAC EASSHNQR" gene complement(27312..28703) /locus_tag="Rv3130c" CDS complement(27312..28703) /locus_tag="Rv3130c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3130c, (MTCY03A2.28, MTCY164.41c), len: 463 aa. Conserved hypothetical protein, similar to several other hypothetical Mycobacterium tuberculosis strain H37Rv proteins e.g. O06795|YH60_MYCTU|Rv1760|MTCY28.26 HYPOTHETICAL 54.1 KDA PROTEIN (502 aa), FASTA scores: opt: 586, E(): 9.8e-29, (28.95% identity in 463 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08399.1" /db_xref="GI:3250712" /db_xref="InterPro:IPR004255" /db_xref="UniProtKB/Swiss-Prot:P0A650" /translation="MNHLTTLDAGFLKAEDVDRHVSLAIGALAVIEGPAPDQEAFLSS LAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWRIALPRPGNEDQLFELIA DLMARRLDRGRPLWEVWVIEGLADSKWAILTKLHHCMADGIAATHLLAGLSDESMSDS FASNIHTTMQSQSASVRRGGFRVNPSEALTASTAVMAGIVRAAKGASEIAAGVLSPAA SSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNVLIQRGERPR FDSLRTLVPVSTRSNSALSKTDNRVSLMLPNLPVDQENPLQRLRIVHSRLTRAKAGGQ RQFGNTLMAIANRLPFPMTAWAVGLLMRLPQRGVVTVATNVPGPRRPLQIMGRRVLDL YPVSPIAMQLRTSVAMLSYADDLYFGILADYDVVADAGQLARGIEDAVARLVAISKRR KVTRRRGALSLVV" gene 28888..29886 /locus_tag="Rv3131" CDS 28888..29886 /locus_tag="Rv3131" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3131, (MTCY03A2.27c), len: 332 aa. Hypothetical protein, similar to other hypothetical bacterial proteins e.g. O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 568, E(): 2.5e-27, (36.7% identity in 321 aa overlap); O05800|Rv3127|MTCY164.37 (344 aa), FASTA scores: opt: 521, E(): 1.9e-24, (34.95% identity in 326 aa overlap); Q9RI33|SCJ12.27c from Streptomyces coelicolor (335 aa), FASTA scores: opt: 441, E(): 1.3e-19, (35.75% identity in 319 aa overlap); Q9RI44|SCJ12.14 from Streptomyces coelicolor (309 aa), FASTA scores: opt: 328, E(): 9.3e-13, (27.9% identity in 308 aa overlap); Q9CBP5|ML1751 from Mycobacterium leprae (721 aa), FASTA scores: opt: 137, E(): 0.78, (26.15% identity in 298 aa overlap); etc. Equivalent to AAK47555 from Mycobacterium tuberculosis strain CDC1551 but shorter 12 aa." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB06283.1" /db_xref="GI:1781236" /db_xref="UniProtKB/TrEMBL:P95195" /translation="MNTHFPDAETVRTVLTLAVRAPSIHNTQPWRWRVCPTSLELFSR PDMQLRSTDPDGRELILSCGVALHHCVVALASLGWQAKVNRFPDPKDRCHLATIGVQP LVPDQADVALAAAIPRRRTDRRAYSCWPVPGGDIALMAARAARGGVMLRQVSALDRMK AIVAQAVLDHVTDEEYLRELTIWSGRYGSVAGVPARNEPPSDPSAPIPGRLFAGPGLS QPSDVLPADDGAAILALGTETDDRLARLRAGEAASIVLLTATAMGLACCPITEPLEIA KTRDAVRAEVFGAGGYPQMLLRVGWAPINADPLPPTPRRELSQVVEWPEELLRQRC" gene complement(29866..31602) /gene="devS" /locus_tag="Rv3132c" CDS complement(29866..31602) /gene="devS" /locus_tag="Rv3132c" /EC_number="2.7.3.-" /function="SENSOR PART OF THE TWO COMPONENT REGULATORY SYSTEM DEVR/DEVS. THOUGHT TO CONTROL HSPX|Rv2031|ACR EXPRESSION." /experiment="experimental evidence, no additional details recorded" /note="Rv3132c, (MTCY03A2.26), len: 578 aa. devS, membrane-bound two component sensor histidine kinase (EC 2.7.3.-) (see citations below; dev for Differentially Expressed in Virulent strain), similar to others two component sensors e.g. Q9RI43|SCJ12.15c PUTATIVE TWO-COMPONENT SENSOR from Streptomyces coelicolor (585 aa), FASTA scores: opt: 1305, E(): 2.5e-69, (41.35% identity in 573 aa overlap); Q9ZBY4|SCD78.15 PUTATIVE TWO COMPONENT SENSOR from Streptomyces coelicolor (560 aa), FASTA scores: opt: 1194, E(): 8.1e-63, (41.05% identity in 558 aa overlap); O85371|CPRS TWO COMPONENT REGULATOR from Rhodococcus sp (563 aa), FASTA scores: opt: 803, E(): 8.3e-40, (38.4% identity in 552 aa overlap); Q9L094|SCC24.23 PUTATIVE TWO-COMPONENT SENSOR HISTIDINE KINASE from Streptomyces coelicolor (similarity only in C-terminus for this one); etc. Also highly similar to mycobacterium O53473|Rv2027c|MTV018.14c PUTATIVE MEMBRANE PROTEIN (573 aa), FASTA scores: opt: 2333, E(): 7.6e-130, (61.45% identity in 576 aa overlap). TBparse score is 0.921." /codon_start=1 /transl_table=11 /product="TWO COMPONENT SENSOR HISTIDINE KINASE DEVS" /protein_id="CAB06282.1" /db_xref="GI:1781235" /db_xref="GOA:P95194" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="UniProtKB/TrEMBL:P95194" /translation="MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEG RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEG IDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPV RVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEA TRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETV GSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGT VAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIAR DLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGAS QGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVVREAVSNAVRHA KASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLASVPGAS GTVLRWSAPLSQ" gene complement(31599..32252) /gene="devR" /locus_tag="Rv3133c" CDS complement(31599..32252) /gene="devR" /locus_tag="Rv3133c" /function="REGULATOR PART OF THE TWO COMPONENT REGULATORY SYSTEM DEVR/DEVS. CONTROLS HSPX|Rv2031|ACR EXPRESSION." /experiment="experimental evidence, no additional details recorded" /note="Rv3133c, (MTCY03A2.25), len: 217 aa. devR, two component transcriptional regulator (see Dasgupta et al., 2000; dev for Differentially Expressed in Virulent strain), highly similar to several e.g. O85372|CPRR TWO COMPONENT REGULATOR from Rhodococcus sp. (212 aa), FASTA scores: opt: 868, E(): 6.2e-46, (65.05% identity in 206 aa overlap); Q9RI42|SCJ12.16c PUTATIVE LUXR FAMILY TWO-COMPONENT RESPONSE REGULATOR from Streptomyces coelicolor (233 aa), FASTA scores: opt: 849, E(): 9.7e-45, (60.55% identity in 218 aa overlap); Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 835, E(): 6.5e-44, (61.55% identity in 208 aa overlap); and similar to others. Contains bacterial regulatory proteins, LuxR family signature (PS00622) near C-terminus as seen in bvgA, comA, dctR, degU, evgA, fimZ, fixJ, gacA, glpR, narL, narP, nodW, rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15 SD). BELONGS TO THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS." /codon_start=1 /transl_table=11 /product="TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY)" /protein_id="CAB06281.1" /db_xref="GI:1781234" /db_xref="GOA:P95193" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="UniProtKB/TrEMBL:P95193" /translation="MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVP AARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYV VKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGL LSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP" misc_feature complement(31680..31763) /gene="devR" /locus_tag="Rv3133c" /note="PS00622 Bacterial regulatory proteins, luxR family signature" gene complement(32280..33086) /locus_tag="Rv3134c" CDS complement(32280..33086) /locus_tag="Rv3134c" /function="UNKNOWN. COULD PLAY A ROLE IN THE ADAPTATION TO HYPOXIA, PARTICIPATING IN THE PHOSPHORELAY IN THE TWO COMPONENT REGULATORY SYSTEM DEVR|Rv3133c/DEVS|Rv3132c." /experiment="experimental evidence, no additional details recorded" /note="Rv3134c, (MTCY03A2.240, len: 268 aa. Ala-, Val- rich protein (see citations below), related to other hypothetical Mycobacterium tuberculosis proteins e.g. O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt: 562, E(): 3.2e-28, (40.65% identity in 273 aa overlap); O06188|Rv2624c|MTCY01A10.08 (272 aa), FASTA scores: opt: 458, E(): 1.1e-21, (36.55% identity in 271 aa overlap); O53472|R2026c|MTV018.13c (294 aa), FASTA scores: opt: 232, E(): 1.9e-07, (30.45% identity in 276 aa overlap); etc. Shares some similarity with other hypothetical proteins from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c (294 aa), FASTA scores: opt: 207, E(): 6.9e-06, (28.9% identity in 263 aa overlap); Q9K4L5|SC5F8.09 PUTATIVE STRESS-INDUCIBLE PROTEIN (312 aa), FASTA scores: opt: 204, E(): 1.1e-05, (28.4% identity in 271 aa overlap); etc. Equivalent to AAK47558|MT3220 Universal stress protein family from Mycobacterium tuberculosis strain CDC1551 (268 aa). Rv3134c seems cotranscribed with devR-devS (see Sherman et al., 2001)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB06280.1" /db_xref="GI:1781233" /db_xref="GOA:P95192" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="UniProtKB/TrEMBL:P95192" /translation="MSDPRPARAVVVGIDGSRAATHAALWAVDEAVNRDIPLRLVYVI DPSQLSAAGEGGGQSAARAALHDASRKVEATGQPVKIETEVLCGRPLTKLMQESRSAA MLCVGSVGLDHVRGRRGSVAATLAGSALCPVAVIHPSPAEPATTSQVSAVVAEVDNGV VLRHAFEEARLRGVPLRAVAVHAAETPDDVEQGSRLAHVHLSRRLAHWTRLYPEVRVD RAIAGGSACRHLAANAKPGQLFVADSHSAHELCGAYQPGCAVLTVRSANL" gene 33671..34069 /gene="PPE50" /locus_tag="Rv3135" CDS 33671..34069 /gene="PPE50" /locus_tag="Rv3135" /function="UNKNOWN" /note="Rv3135, (MTCY03A2.23c), len: 132 aa. Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to P95190|Rv3136|MTCY03A2.22c (380 aa), FASTA scores: opt: 494, E(): 6.7e-25, (57.25% identity in 131 aa overlap) (next ORF downstream), MTY21C12_9, MTCY3C7_24, MTCI125_27, MTV049_12, MTV049_9, MTV049_11 , MTCY274_24 etc. TBparse score is 0.912." /codon_start=1 /transl_table=11 /product="PPE FAMILY PROTEIN" /protein_id="CAE55558.1" /db_xref="GI:38490329" /db_xref="InterPro:IPR000030" /db_xref="InterPro:IPR010916" /db_xref="UniProtKB/TrEMBL:Q6MX07" /translation="MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAEN YGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTATQARAAAAAFEQAHA MTVPPALVTGIRGAIVVETASASNTAGTPP" gene 34131..35273 /gene="PPE51" /locus_tag="Rv3136" CDS 34131..35273 /gene="PPE51" /locus_tag="Rv3136" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3136, (MTCY03A2.22c), len: 380 aa. Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to Q9AGF0|Ov2770c Rv2770c-LIKE PROTEIN from M. microti (397 aa), FASTA scores: opt: 917, E(): 9e-41, (46.15% identity in 388 aa overlap); O33312|Rv2770c|MTV002.35c, MTV002_36, MTCI125_26, MTCY10G2_10, MTCI364_8, MTV049_28, MTV049_29, etc. TBparse score is 0.923." /codon_start=1 /transl_table=11 /product="PPE FAMILY PROTEIN" /protein_id="CAE55559.1" /db_xref="GI:38490330" /db_xref="InterPro:IPR000030" /db_xref="UniProtKB/TrEMBL:Q7D623" /translation="MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAELATTAEA YGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTAIQARAAALAFEQAYA MTLPPPVVAANRIQLLALIATNFFGQNTAAIAATEAQYAEMWAQDAAAMYGYATASAA AALLTPFSPPRQTTNPAGLTAQAAAVSQATDPLSLLIETVTQALQALTIPSFIPEDFT FLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEVTPGDFGIGELVSA TSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLT TLPGTDVAEHGMPGVPGVPVAAGRASGVLPRYGVRLTVMAHPPAAG" gene 35730..36512 /locus_tag="Rv3137" CDS 35730..36512 /locus_tag="Rv3137" /EC_number="3.1.3.-" /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM." /note="Rv3137, (MTCY03A2.21c), len: 260 aa. Probable monophosphatase (EC 3.1.3.-), equivalent to O32889|MLCB1779_19|ML0662 PUTATIVE MONOPHOSPHATASE from Mycobacterium leprae (255 aa), FASTA scores: opt: 1403, E(): 1.2e-81, (81.8% identity in 253 aa overlap). Also similar to Q9K4B1|SC7E4.05c from Streptomyces coelicolor (266 aa), FASTA scores: opt: 969, E(): 3.5e-54, (57.9% identity in 259 aa overlap); Q53743|PUR3 MONO-PHOSPHATASE from Streptomyces lipmanii (Streptomyces alboniger) (273 aa), FASTA scores: opt: 862, E(): 2.1e-47, (55.25% identity in 257 aa overlap); BAB50023|MLL3039 MONO-PHOSPHATASE from Rhizobium loti (Mesorhizobium loti) (262 aa), FASTA scores: opt: 448, E(): 3.2e-21, (31.37% identity in 255 aa overlap); etc. Contains inositol monophosphatase family signature 1 (PS00629). TBparse score is 0.881." /codon_start=1 /transl_table=11 /product="PROBABLE MONOPHOSPHATASE" /protein_id="CAB06277.1" /db_xref="GI:1781230" /db_xref="GOA:P95189" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR011809" /db_xref="UniProtKB/TrEMBL:P95189" /translation="MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDAD RAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLI ALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFS SLSGWARPGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALD IVVREAGGRLTSLDGVAGPHGGSAVATNGLLHDEVLTRLNAG" misc_feature 35967..36008 /locus_tag="Rv3137" /note="PS00629 Inositol monophosphatase family signature 1" gene 36532..37620 /gene="pflA" /locus_tag="Rv3138" CDS 36532..37620 /gene="pflA" /locus_tag="Rv3138" /EC_number="1.97.1.4" /function="INVOLVED IN CELLULAR METABOLISM [CATALYTIC ACTIVITY: S-adenosyl-L-methionine + dihydroflavodoxin + [formate acetyltransferase]-glycine = 5'-deoxyadenosine + methionine + flavodoxin + [formate acetyltransferase]-glycine-2-yl radical]." /experiment="experimental evidence, no additional details recorded" /note="Rv3138, (MTCY03A2.20c), len: 362 aa. Probable pflA, pyruvate formate lyase activating protein (EC 1.97.1.4), similar to other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa), FASTA scores: opt: 926, E(): 1.1e-52, (39.95% identity in 343 aa overlap); O27446|MTH1395 from Methanobacterium thermoautotrophicum (335 aa), FASTA scores: opt: 909, E(): 1.3e-51, (42.2% identity in 327 aa overlap); O28939|AF1330 from Archaeoglobus fulgidus (336 aa), FASTA scores: opt: 884, E(): 5.6e-50, (42.0% identity in 319 aa overlap); etc. Also similar to O50099|PH1391 HYPOTHETICAL 40.2 KDA PROTEIN from Pyrococcus horikoshii (348 aa), FASTA scores: opt: 934, E(): 3.3e-53, (40.5% identity in 343 aa overlap); and other hypothetical proteins. TBparse score is 0.881." /codon_start=1 /transl_table=11 /product="PROBABLE PYRUVATE FORMATE LYASE ACTIVATING PROTEIN PFLA (FORMATE ACETYLTRANSFERASE ACTIVATING ENZYME) ([PYRUVATE FORMATE-LYASE] ACTIVATING ENZYME)" /protein_id="CAB06292.1" /db_xref="GI:3261696" /db_xref="GOA:P95188" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="UniProtKB/TrEMBL:P95188" /translation="MSDPFTIATKHWHRLHDSRIQCDVCPRACKLHEGQRGLCFVRGR FDDQVKLTSYGRSSGFCVDPIEKKPLNHFLPGSATLSFGTAGCNLACKFCQNWDISKS REIDVLASRAAPADIARTAHELGCRSVAFTYNDPTIFWEYAADVADACHDQGIKAVAV TAGYMCPEPRAEFYRRVDAANVDLKAFTEDFYRKVCVSHLRNVLDTLAYLRHQTNVWL EITTLLIPGRNDSDAEVAAECRWIRENLGVDVPVHFTAFHPDYKMMDTPATPTATLTR AREIGIGEGLRFVYTGNVHDAVGGSTSCPGCRATVIVRDWYSIRHYALTEDGRCQACG YQMPGVYDGPAGHWGQRRLPLLTSLSRM" gene 37700..39106 /gene="fadE24" /locus_tag="Rv3139" CDS 37700..39106 /gene="fadE24" /locus_tag="Rv3139" /EC_number="1.3.99.-" /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." /experiment="experimental evidence, no additional details recorded" /note="Rv3139, (MTCY03A2.19c), len: 468 aa. Probable fadE24, acyl-CoA dehydrogenase (1.3.99.-), equivalent to O32890|MLCB1779.30|FADE24|ML0661 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (465 aa), FASTA scores: opt: 2587, E(): 4e-153, (83.6% identity in 464 aa overlap). Similar to other e.g. Q9HUH0|PA4995 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 1139, E(): 2.8e-63, (45.3% identity in 426 aa overlap); Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa), FASTA scores: opt: 603, E(): 4.7e-30, (30.3% identity in 366 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 601, E(): 6.3e-30, (32.25% identity in 363 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 2 (PS00073) near C-terminus. BELONGS TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.881." /codon_start=1 /transl_table=11 /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE24" /protein_id="CAB06276.1" /db_xref="GI:1781228" /db_xref="GOA:P95187" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006090" /db_xref="InterPro:IPR006092" /db_xref="UniProtKB/TrEMBL:P95187" /translation="MTNTTSAANAAKPSGARTDRRGRTTGVGLAPHKRTGIDVALALL TPIVGQEFLDKYRLRDPLNRSLRYGVKTMFATAGAATRQFQRVQGLRGGPTRLKSSGR DYFDLTPDDDQKLIIETVDEFAEEVLRPAAHDADDAATYPSDLTAKAAELGITAINIP EDFDGIAEHRSSVTNVLVAEALAYGDMGLALPILAPGGVASALTHWGSADQQATYLKE FAGENVPQACVAITEPQPLFDPTRLKTTAVRTPSGYRLDGVKSLIPAAADAELFIVGA QLGGKPALFIVESAASGLTVKADPSMGIRGAALGQVELCGVSVPLNARLGEDEASDND YSEALALARLGWAALAVGTSHAVLDYVVPYVKQRQAFGEPIAHRQAVAFMCANIAIEL DGLRLITWRGASRAEQGLPFAREAALAKRLGSDKGMQIGLDGVQLLGGHGYTKEHPVE RWYRDLRAIGVAEGVVVI" misc_feature 39005..39064 /gene="fadE24" /locus_tag="Rv3139" /note="PS00073 Acyl-CoA dehydrogenases signature 2" gene 39127..40332 /gene="fadE23" /locus_tag="Rv3140" CDS 39127..40332 /gene="fadE23" /locus_tag="Rv3140" /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION." /experiment="experimental evidence, no additional details recorded" /note="Rv3140, (MTCY03A2.18c), len: 401 aa. Probable fadE23, acyl-CoA dehydrogenase (1.3.99.-) (see citation below), equivalent to O32891|MLCB1779.31|FADE23|ML0660 PUTATIVE ACYL-CoA DEHYDROGENASE from Mycobacterium leprae (400 aa), FASTA scores: opt: 2307, E(): 3e-136, (89.5% identity in 401 aa overlap). Also similar to others e.g. Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 1558, E(): 1.2e-89, (61.0% identity in 400 aa overlap); O31251 from Acinetobacter sp. ADP1 (401 aa), FASTA scores: opt: 1509, E(): 1.3e-86, (58.2% identity in 402 aa overlap); Q9K6D1|ACDA OR BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 612, E(): 8.4e-31, (38.2% identity in 293 aa overlap); Q9AHX9|FADFX from Pseudomonas putida (375 aa), FASTA scores: opt: 584, E(): 4.6e-29, (32.7% identity in 379 aa overlap); etc. COULD BELONG TO THE ACYL-CoA DEHYDROGENASES FAMILY. TBparse score is 0.890." /codon_start=1 /transl_table=11 /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE23" /protein_id="CAB06275.1" /db_xref="GI:1781227" /db_xref="GOA:P95186" /db_xref="InterPro:IPR006090" /db_xref="InterPro:IPR006091" /db_xref="UniProtKB/TrEMBL:P95186" /translation="MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVEL DTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSL PYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVING EKIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTA VIRFDNARIPKGNLLGNPEIEVGKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSV LTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMS KAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRL LGLSSSELK" gene 40432..41403 /gene="fadB4" /locus_tag="Rv3141" CDS 40432..41403 /gene="fadB4" /locus_tag="Rv3141" /EC_number="1.6.5.5" /function="INVOLVED IN LIPID DEGRADATION [CATALYTIC ACTIVITY: NADPH + QUINONE = NADP(+) + SEMIQUINONE]." /experiment="experimental evidence, no additional details recorded" /note="Rv3141, (MTCY03A2.17c), len: 323 aa. Probable fadB4, quinone oxidoreductase (EC 1.6.5.5), showing strong similarity to variety of quinone oxidoreductases and domains in polyketide and fatty acid synthases e.g. Q9HTV6|PA5234 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (325 aa), FASTA scores: opt: 737, E(): 1.4e-35, (39.65% identity in 328 aa overlap); Q9RYQ7|DRA0251 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (336 aa), FASTA scores: opt: 688, E(): 1e-32, (40.6% identity in 325 aa overlap); Q9RVG8|DR1061 PUTATIVE NADPH QUINONE OXIDOREDUCTASE from Deinococcus radiodurans (388 aa), FASTA scores: opt: 559, E(): 3.3e-25, (36.3% identity in 325 aa overlap); BAB49685|MLL2594 PROBABLE QUINONE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (326 aa), FASTA scores: opt: 519, E(): 5.9e-23, (34.25% identity in 330 aa overlap); Q9LXZ4|T5P19_110 QUINONE REDUCTASE-LIKE PROTEIN from Arabidopsis thaliana (348 aa), FASTA scores: opt: 517, E(): 8.1e-23, (33.55% identity in 322 aa overlap); etc. Also similar to Q9AA38|CC0770 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (325 aa), FASTA scores: opt: 673, E(): 7.2e-32, (40.2% identity in 326 aa overlap); and Q9ABX4|CC0096 ZINC-CONTAINING ALCOHOL DEHYDROGENASE from Caulobacter crescentus (332 aa), FASTA scores: opt: 623, E(): 5.7e-29, (40.7% identity in 334 aa overlap). Also resembles Mycobacterium tuberculosis proteins P96826|Rv0149|MTCI5_23, MTCY13D12.11, MTCY24G1.03, MTCY19H9.01. BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE OXIDOREDUCTASE SUBFAMILY. TBparse score is 0.904. Thought to be differentially expressed within host cells (see Triccas et al., 1999)." /codon_start=1 /transl_table=11 /product="PROBABLE NADPH QUINONE OXIDOREDUCTASE FADB4 (NADPH:QUINONE REDUCTASE) (ZETA-CRYSTALLIN)" /protein_id="CAB06274.1" /db_xref="GI:1781226" /db_xref="GOA:P95185" /db_xref="InterPro:IPR002085" /db_xref="UniProtKB/TrEMBL:P95185" /translation="MRAVRVTRLEGPDAVEVAEVEEPTSAGVVIEVHAAGVAFPDALL TRGRYQYRPEPPFVLGAEIAGVVRSAPDNSQVRSGDRVVGLTMLTGGMAEVAVLSPER VFKLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAGGIGTSTLRLAPA LGASRTVAVVSTQEKAELATVAGATDVVLAEGFKDAVQELTNGRGVDIVVDPVGGDRF TDSLRSLAAGGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWSLTHPDALAQQW SQLERLLRSGKLPPPEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD" gene complement(41455..41883) /locus_tag="Rv3142c" CDS complement(41455..41883) /locus_tag="Rv3142c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3142c, (MTCY03A2.16), len: 142 aa. Hypothetical unknown protein. Equivalent to AAK47569 from Mycobacterium tuberculosis strain CDC1551 but shorter 33 aa. TBparse score is 0.921." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAB06273.1" /db_xref="GI:1781225" /db_xref="UniProtKB/TrEMBL:P95184" /translation="MTEQEMTEQWLEGCAVQRIMFRDGLVLNFDDYNELVISVPLQLT LPAIETSPAEVVAIDPNDPADHERPLFDFAGATCTAFVWYDTGDLHLEFSDGHQIDVH PDDRVTAWELYGKYHGYAACLAPGKLRVVRHDVADANGDQ" gene 41991..42392 /locus_tag="Rv3143" CDS 41991..42392 /locus_tag="Rv3143" /function="UNKNOWN, BUT COULD BE INVOLVED IN REGULATORY MECHANISM" /note="Rv3143, (MTCY03A2.15c), len: 133 aa. Probable response regulator, similar to other sensory transduction regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor (133 aa), FASTA scores: opt: 474, E(): 2.8e-24, (54.15% identity in 120 aa overlap); Q9KZ82|SCE25.04c from Streptomyces coelicolor (225 aa), FASTA scores: opt: 144, E(): 0.016, (32.3% identity in 127 aa overlap); Q9RZT4|DRB0029 from Deinococcus radiodurans (416 aa), FASTA scores: opt: 145, E(): 0.024, (30.65% identity in 124 aa overlap). SIMILAR TO OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS." /codon_start=1 /transl_table=11 /product="PROBABLE RESPONSE REGULATOR" /protein_id="CAB06272.1" /db_xref="GI:1781224" /db_xref="GOA:P95183" /db_xref="InterPro:IPR001789" /db_xref="UniProtKB/TrEMBL:P95183" /translation="MPDSSTALRILVYSDNVQTRERVMRALGKRLHPDLPDLTYVEVA TGPMVIRQMDRGGIDLAILDGEATPTGGMGIAKQLKDELASCPPILVLTGRPDDTWLA SWSRAEAAVPHPVDPIVLGRTVLSLLRAPAH" gene complement(42425..43654) /gene="PPE52" /locus_tag="Rv3144c" CDS complement(42425..43654) /gene="PPE52" /locus_tag="Rv3144c" /function="UNKNOWN" /note="Rv3144c, (MTCY03A2.14), len: 409 aa. Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-rich, similar to others e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1007, E(): 5.2e-35, (56.2% identity in 306 aa overlap); and MTV014_3, MTCY6G11_5, MTCY98.0034c, MTCY31.06c, MTCY48.17, MTCY98.0029c, MTCY03C7.17c, etc. TBparse score is 0.891." /codon_start=1 /transl_table=11 /product="PPE-FAMILY PROTEIN" /protein_id="CAE55560.1" /db_xref="GI:38490331" /db_xref="InterPro:IPR000030" /db_xref="UniProtKB/TrEMBL:Q6MX05" /translation="MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQS FASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQA ATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASA IAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASG GGVGYVGSGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFI GAPLALAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPT VDPKVAAKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAG QLRPRVRKDPKIQMRGG" gene 44019..44405 /gene="nuoA" /locus_tag="Rv3145" CDS 44019..44405 /gene="nuoA" /locus_tag="Rv3145" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3145, (MTCY03A2.13c), len: 128 aa. Probable nuoA, integral membrane NADH dehydrogenase, chain A (EC 1.6.5.3), similar to others e.g. Q9XAQ4|NUOA from Streptomyces coelicolor (119 aa), FASTA scores: opt: 405, E(): 5.4e-20, (68.75% identity in 128 aa overlap); Q9RU86|DR1506 from Deinococcus radiodurans (160 aa), FASTA scores: opt: 327, E(): 9e-15, (40.3% identity in 124 aa overlap); BAB47039|NDHC from Triticum aestivum (Wheat), FASTA scores: opt: 273, E(): 2.6e-11, (38.1% identity in 126 aa overlap); etc. Also similar to a NADH-PLASTOQUINONE OXIDOREDUCTASES e.g. P26303|NU3C_WHEAT|NDHC from Triticum aestivum (Wheat) (120 aa), FASTA scores: opt: 273, E(): 2.6e-1, (38.1% identity in 126 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 3 FAMILY. TBparse score is 0.895." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN A) NUOA (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN A)" /protein_id="CAB06271.1" /db_xref="GI:1781223" /db_xref="GOA:P65563" /db_xref="InterPro:IPR000440" /db_xref="UniProtKB/Swiss-Prot:P65563" /translation="MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECG IEPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFAL VEMAIFMLTVFVAYAYVWRRGGLTWD" gene 44414..44968 /gene="nuoB" /locus_tag="Rv3146" CDS 44414..44968 /gene="nuoB" /locus_tag="Rv3146" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3146, (MTCY03A2.12c), len: 184 aa. Probable nuoB, NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. Q9XAQ5|NUOB from Streptomyces coelicolor (184 aa), FASTA scores: opt: 989, E(): 1.4e-56, (78.25% identity in 184 aa overlap); Q56218|NQO6_THETH|NQO6 from Thermus aquaticus (subsp. thermophilus) (181 aa), FASTA scores: opt: 720, E(): 2.6e-39, (64.45% identity in 152 aa overlap); Q9RU87|DR1505 from Deinococcus radiodurans (181 aa), FASTA scores: opt: 719, E(): 3e-39, (62.6% identity in 155 aa overlap); etc. BELONGS TO THE COMPLEX I 20 KDA SUBUNIT FAMILY. MAY CONTAIN AN IRON-SULFUR 4FE-4S CLUSTER. TBparse score is 0.912." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN B) NUOB (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN B)" /protein_id="CAB06270.1" /db_xref="GI:1781222" /db_xref="GOA:P65575" /db_xref="InterPro:IPR006137" /db_xref="InterPro:IPR006138" /db_xref="UniProtKB/Swiss-Prot:P65575" /translation="MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMA TAGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGV CASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQQMPLGINRE RAIAEAEEAALLARPTIEMRGLLR" gene 44965..45675 /gene="nuoC" /locus_tag="Rv3147" CDS 44965..45675 /gene="nuoC" /locus_tag="Rv3147" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3147, (MTCY03A2.11c), len: 236 aa. Probable nuoC, NADH dehydrogenase, chain C (EC 1.6.5.3), similar to others e.g. Q9XAQ6|NUOC from Streptomyces coelicolor (251 aa), FASTA scores: opt: 1113, E(): 2.6e-64, (67.35% identity in 236 aa overlap); Q9A6X2|CC1954 from Caulobacter crescentus (197 aa), FASTA scores: opt: 351, E(): 1.6e-15, (41.65% identity in 132 aa overlap); BAB48757|MLL1369 from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 347, E(): 3e-15, (42.4% identity in 132 aa overlap); etc. Also similar to Q9UUU0|NUGM NUGM PROTEIN PRECURSOR (EC 1.6.99.3) from Yarrowia lipolytica (Candida lipolytica) (281 aa), FASTA scores: opt: 356, E(): 1.1e-15, (34.55% identity in 162 aa overlap). Also similar to MTCY251.05, FASTA score: E():4.9e-05. Equivalent to AAK47574 from Mycobacterium tuberculosis strain CDC1551 but longer 26 aa. BELONGS TO THE COMPLEX I 30 KDA SUBUNIT FAMILY. TBparse score is 0.893." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN C) NUOC (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN C)" /protein_id="CAB06269.1" /db_xref="GI:1781221" /db_xref="GOA:P65571" /db_xref="InterPro:IPR001268" /db_xref="InterPro:IPR008992" /db_xref="InterPro:IPR010218" /db_xref="UniProtKB/Swiss-Prot:P65571" /translation="MSPPNQDAQEGRPDSPTAEVVDVRRGMFGVSGTGDTSGYGRLVR QVVLPGSSPRPYGGYFDDIVDRLAEALRHERVEFEDAVEKVVVYRDELTLHVRRDLLP RVAQRLRDEPELRFELCLGVSGVHYPHETGRELHAVYPLQSITHNRRLRLEVSAPDSD PHIPSLFAIYPTNDWHERETYDFFGIIFDGHPALTRIEMPDDWQGHPQRKDYPLGGIP VEYKGAQIPPPDERRGYN" gene 45675..46997 /gene="nuoD" /locus_tag="Rv3148" CDS 45675..46997 /gene="nuoD" /locus_tag="Rv3148" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3148, (MTCY03A2.10c), len: 440 aa. Probable nuoD, NADH dehydrogenase, chain B (EC 1.6.5.3), similar to others e.g. Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa), FASTA scores: opt: 2198, E(): 1e-131, (73.9% identity in 429 aa overlap); P15689|NUCM_PARTE from Paramecium tetraurelia (400 aa), FASTA scores: opt: 922, E(): 5.8e-51, (38.5% identity in 408 aa overlap); Q9RU89|NUOD_DEIRA|DR1503 from Deinococcus radiodurans (401 aa), FASTA scores: opt: 922, E(): 5.8e-51, (47.75% identity in 404 aa overlap); etc. Equivalent to AAK47575 from Mycobacterium tuberculosis strain CDC1551 but longer 42 aa. Contains helix-turn-helix motif at aa 340-361. BELONGS TO THE COMPLEX I 49 KDA SUBUNIT FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN D) NUOD (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN D)" /protein_id="CAB06291.1" /db_xref="GI:1781220" /db_xref="GOA:P65569" /db_xref="InterPro:IPR001135" /db_xref="InterPro:IPR010219" /db_xref="UniProtKB/Swiss-Prot:P65569" /translation="MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMG PQHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLS PFFNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTP MFVGFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLRE MGELLNENAIWKARTQGVGYLDLTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYE FDVITDDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGP DGLGNSPKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDG GTRPYRVHYRDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR" gene 46994..47752 /gene="nuoE" /locus_tag="Rv3149" CDS 46994..47752 /gene="nuoE" /locus_tag="Rv3149" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3149, (MTCY03A2.09c), len: 252 aa. Probable nuoE, NADH dehydrogenase, chain E (EC 1.6.5.3), similar to others e.g. Q9XAQ8|NUOE from Streptomyces coelicolor (290 aa), FASTA scores: opt: 1002, E(): 5.7e-55, (69.5% identity in 213 aa overlap); P40915|NUHM_NEUCR|NUO-24 from Neurospora crassa (263 aa), FASTA scores: opt: 412, E(): 1.9e-18, (38055% identity in 192 aa overlap); P19234|NUHM_RAT from Rattus norvegicus (Rat) (241 aa), FASTA scores: opt: 410, E(): 2.4e-18, (23.9% identity in 237 aa overlap); etc. BELONGS TO THE COMPLEX I 24 KDA SUBUNIT FAMILY. BINDS A 2FE-2S CLUSTER (POTENTIAL)." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN E) NUOE (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN E)" /protein_id="CAB06290.1" /db_xref="GI:1781219" /db_xref="GOA:P65573" /db_xref="InterPro:IPR002023" /db_xref="UniProtKB/Swiss-Prot:P65573" /translation="MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDA KEIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYR RRPTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACD YAPVVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQR PDEGQGGPGAPTLAGLQVARKNDMQAPPTPGADE" gene 47749..49086 /gene="nuoF" /locus_tag="Rv3150" CDS 47749..49086 /gene="nuoF" /locus_tag="Rv3150" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3150, (MTCY03A2.08c), len: 445 aa. Probable nuoF, NADH dehydrogenase, chain F (EC 1.6.5.3), similar to others e.g. Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449 aa), FASTA scores: opt: 2314, E(): 3.5e-139, (76.25% identity in 434 aa overlap); NUF2_RHIME from Rhizobium meliloti (421 aa), FASTA scores: opt: 1545, E(): 1.8e-90, (53.1% identity in 424 aa overlap); Q9RU92|DR1500 from Deinococcus radiodurans (444 aa), FASTA scores: opt: 1445, E(): 4.1e-84, (52.9% identity in 427 aa overlap); etc. Contains respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2 (PS00645). BELONGS TO THE COMPLEX I 51 KDA SUBUNIT FAMILY. COFACTOR: FMN AND ONE 4FE-4S CLUSTER (PROBABLE). TBparse score is 0.889." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN F) NUOF (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN F)" /protein_id="CAB06289.1" /db_xref="GI:1781218" /db_xref="GOA:P65567" /db_xref="InterPro:IPR001949" /db_xref="UniProtKB/Swiss-Prot:P65567" /translation="MTTQATPLTPVISRHWDDPESWTLATYQRHDRYRGYQALQKALT MPPDDVISIVKDSGLRGRGGAGFATGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTC KDIPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVVPVLRRLHNAVAEAYAAGFLG RNIGGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTV INNVETIASVPSIILGGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLREL LDYAGGVRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDET TCVVRAVRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDISDS ILGKSFCALGDGAASPVMSSIKHFRDEYLAHVEGGGCPFDPRDSMLVANGVDA" misc_feature 48799..48834 /gene="nuoF" /locus_tag="Rv3150" /note="PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2" gene 49083..51503 /gene="nuoG" /locus_tag="Rv3151" CDS 49083..51503 /gene="nuoG" /locus_tag="Rv3151" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /note="Rv3151, (MTCY03A2.07c), len: 806 aa. Probable nuoG, NADH dehydrogenase I, chain G (EC 1.6.5.3), similar to others e.g. Q9XAR0|NUOG_STRCO from Streptomyces coelicolor (843 aa), FASTA scores: opt: 1968 ,E(): 5.2e-107, (62.45% identity in 818 aa overlap); P56914|NUG2_RHIME from Rhizobium meliloti (853 aa), FASTA scores: opt: 964, E(): 1.6e-48, (30.6% identity in 840 aa overlap); etc. But also similarity with other proteins e.g. P77908|FDHA FORMATE DEHYDROGENASE, ALPHA SUBUNIT (EC 1.2.1.43) (FORMATE DEHYDROGENASE [NADP+]) from Moorella thermoacetica (Clostridium thermoaceticum) (893 aa), FASTA scores: opt: 928, E(): 2e-46, (28.65% identity in 865 aa overlap); and Q9UUU3|NUAM NUAM PROTEIN PRECURSOR (EC 1.6.99.3) from Yarrowia lipolytica (Candida lipolytica) (728 aa), FASTA scores: opt: 894, E(): 1.7e-44, (31.95% identity in 676 aa overlap). Equivalent to AAK47578 from Mycobacterium tuberculosis strain CDC1551 but longer 15 aa. Contains respiratory-chain NADH dehydrogenase 75 kDa subunit signature 2 (PS00642). BELONGS TO THE COMPLEX I 75 KDA SUBUNIT FAMILY. COFACTOR: MAY BIND TWO 4FE-4S CLUSTER AND ONE 2FE-2S CLUSTER. TBparse score is 0.887." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G)" /protein_id="CAB06288.1" /db_xref="GI:1781217" /db_xref="GOA:P95175" /db_xref="InterPro:IPR000283" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR001450" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR010228" /db_xref="UniProtKB/Swiss-Prot:P95175" /translation="MTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQ IPRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHG VMELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLD RERCILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGA LTGTAYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCD KGRWAFTYATQPDVITTPLIRDGGDPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVG GRVTWEDAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESA PVVLLVGFEPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGE PAALDDLATGAVGDLLATPGAVIIVGERLATVPGGLSAAARLADTTGARLAWVPRRAG ERGALEAGALPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETL AALLVGGIEPADFADPDAVLAALDATGFVVSLELRHSTVTERADVVFPVAPTTQKAGA FVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGI WDGKHAAGPHIAATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSP DTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGS IVKIGAGS" misc_feature 49425..49463 /gene="nuoG" /locus_tag="Rv3151" /note="PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2" gene 51619..52851 /gene="nuoH" /locus_tag="Rv3152" CDS 51619..52851 /gene="nuoH" /locus_tag="Rv3152" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3152, (MTCY03A2.06c), len: 410 aa. Probable nuoH, integral membrane NADH dehydrogenase I, chain H (EC 1.6.5.3), similar to others e.g. Q9XAR1 Q9XAR1|NUOH from Streptomyces coelicolor (467 aa), FASTA scores: opt: 1630, E(): 3.4e-90, (58.35% identity in 413 aa overlap); Q9RU94|DR1498 from Deinococcus radiodurans (397 aa), FASTA scores: opt: 1081, E(): 2e-57, (45.5% identity in 391 aa overlap); Q9ZCF7|NUOH_RICPR|RP796 from Rickettsia prowazekii (339 aa), FASTA scores: opt: 976, E(): 3.4e-51, (46.2% identity in 329 aa overlap); etc. Contains respiratory-chain NADH dehydrogenase subunit 1 signature 2 (PS00668). Some similarity to MTCY251.02 (FASTA score: E(): 1.2e-07). BELONGS TO THE COMPLEX I SUBUNIT 1 FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN H) NUOH (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN H)" /protein_id="CAB06287.1" /db_xref="GI:1781216" /db_xref="GOA:P65561" /db_xref="InterPro:IPR001694" /db_xref="UniProtKB/Swiss-Prot:P65561" /translation="MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLR PGPNRVGPKGALQSLADGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFG PEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQV ISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAP FDLPEAEGELVAGFHTEYSSLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMW ASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVA AIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEP AFPTPPLLAGATKENAGG" misc_feature 52270..52311 /gene="nuoH" /locus_tag="Rv3152" /note="PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2" gene 52844..53479 /gene="nuoI" /locus_tag="Rv3153" CDS 52844..53479 /gene="nuoI" /locus_tag="Rv3153" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3153, (MTCY03A2.05c), len: 211 aa. Probable nuoI, NADH dehydrogenase I, chain I (EC 1.6.5.3), similar to others e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211 aa), FASTA scores: opt: 825, E(): 9.3e-44, (70.1% identity in 164 aa overlap); Q56224|NQO9_THETH from Thermus aquaticus (subsp. thermophilus) (182 aa), FASTA scores: opt: 543, E(): 1.8e-26, (50.9% identity in 163 aa overlap); Q9RU95|DR1497 from Deinococcus radiodurans (178 aa), FASTA scores: opt: 527, E(): 1.7e-25, (48.75% identity in 162 aa overlap); etc. Contains two 4Fe-4S ferredoxins, iron-sulfur binding region signatures (PS00198). BELONGS TO THE COMPLEX I 23 KDA SUBUNIT FAMILY. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. COFACTOR: BINDS TWO 4FE-4S CLUSTERS. TBparse score is 0.952." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN I) NUOI (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN I)" /protein_id="CAB06286.1" /db_xref="GI:1781215" /db_xref="GOA:P95173" /db_xref="InterPro:IPR001450" /db_xref="InterPro:IPR010226" /db_xref="UniProtKB/Swiss-Prot:P95173" /translation="MANTDRPALPHKRAVPPSRADSGPRRRRTKLLDAVAGFGVTLGS MFKKTVTEEYPERPGPVAARYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGAD NTEEERFSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTYDYELADDNRADLIYE KDRLLAPLLPEMAAPPHPRTPGATDKDYYLGNVTAEGLRGVRESQTTGDSR" misc_feature 53084..53119 /gene="nuoI" /locus_tag="Rv3153" /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature" misc_feature 53219..53254 /gene="nuoI" /locus_tag="Rv3153" /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature" gene 53476..54264 /gene="nuoJ" /locus_tag="Rv3154" CDS 53476..54264 /gene="nuoJ" /locus_tag="Rv3154" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3154, (MTCY03A2.04c), len: 262 aa. Probable nuoJ, transmembrane NADH dehydrogenase I, chain J (EC 1.6.5.3), similar to others e.g. Q9XAR3|NUOJ from Streptomyces coelicolor (285 aa), FASTA scores: opt: 991, E(): 3.2e-52, (63.7% identity in 243 aa overlap); Q9JX90|NUOJ|NMA0006 from Neisseria meningitidis (serogroup A) (223 aa), FASTA scores: opt: 329, E(): 9.6e-13, (34.85% identity in 175 aa overlap); Q9K1B2|NMB0253 from Neisseria meningitidis (serogroup B) (223 aa), FASTA scores: opt: 326, E(): 1.5e-12, (34.85% identity in 175 aa overlap); etc. But also similarity with Q00243|NU6C_PLEBO|NDH6 NADH-PLASTOQUINONE OXIDOREDUCTASE CHAIN 6 HOMOLOG (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) from Plectonema boryanum (199 aa), FASTA scores: opt: 287, E(): 2.8e-10, (34.35% identity in 195 aa overlap). SIMILAR TO POLYPEPTIDE 6 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIA. TBparse score is 0.890." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN J) NUOJ (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN J)" /protein_id="CAB06285.1" /db_xref="GI:1781214" /db_xref="GOA:P95172" /db_xref="InterPro:IPR001457" /db_xref="UniProtKB/TrEMBL:P95172" /translation="MTAVLASDVIVRTSTGEAVMFWVLSALALLGAVGVVLAVNAVYS AMFLAMTMIILAVFYMAQDALFLGVVQVVVYTGAVMMLFLFVLMLIGVDSAESLKETL RGQRVAAVLTGVGFGVLLISTIGQVATRGFAGLTVANANGNVEGLAALIFSRYLWAFE LTSALLITAAVGAMVLAHRERFERRKTQRELSQERFRPGGHPTPLPNPGVYARHNAVD VAALLPDGSYSELSVPRMLRTRGADGLQTPSPGAVSGSLEGGAS" gene 54261..54560 /gene="nuoK" /locus_tag="Rv3155" CDS 54261..54560 /gene="nuoK" /locus_tag="Rv3155" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3155, (MTCY03A2.03c), len: 99 aa. Probable nuoK, integral membrane NADH dehydrogenase I, chain K (EC 1.6.5.3), similar to others e.g. Q9XAR4|NUOK from Streptomyces coelicolor (99 aa), FASTA scores: opt: 509, E(): 2.7e-31, (78.55% identity in 98 aa overlap); Q56226|NQOB_THETH|NQO11 from Thermus aquaticus (subsp. thermophilus) (95 aa), BLAST scores: initn: 298, init1: 180, bits: 85.7, FASTA scores: opt: 313, E(): 9.4e-17, (53.7% identity in 95 aa overlap); Q9RU97|DR1495 from Deinococcus radiodurans (103 aa), FASTA scores: opt: 309, E(): 2e-16, (52.0% identity in 100 aa overlap); etc. But also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES CHAIN 4L e.g. Q9MUL4|NULC_MESVI|NDHE from Mesostigma viride (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) (101 aa), FASTA scores: opt: 280, E(): 2.8e-14, (40.6% identity in 101 aa overlap); and P06261|NULC_TOBAC|NDHE|NDH4L from Nicotiana tabacum (Common tobacco) (101 aa), FASTA scores: opt: 259, E(): 1e-12, (43.0% identity in 93 aa overlap). SIMILAR TO POLYPEPTIDE 4L OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIA. TBparse score is 0.897." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN K) NUOK (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN K)" /protein_id="CAB06284.1" /db_xref="GI:1781213" /db_xref="GOA:P65565" /db_xref="InterPro:IPR001133" /db_xref="InterPro:IPR003214" /db_xref="InterPro:IPR003215" /db_xref="UniProtKB/Swiss-Prot:P65565" /translation="MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLA FVTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG" gene 54571..56472 /gene="nuoL" /locus_tag="Rv3156" CDS 54571..56472 /gene="nuoL" /locus_tag="Rv3156" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3156, (MTCY03A2.02c), len: 633 aa. Probable nuoL, integral membrane NADH dehydrogenase I, chain L (EC 1.6.5.3), similar to others e.g. Q9XAR5|NUOL_STRCO from Streptomyces coelicolor (654 aa), FASTA scores: opt: 2074, E(): 1.1e-111, (61.1% identity in 648 aa overlap); Q56227|NQOC_THETH|NQO12 from Thermus aquaticus (subsp. thermophilus) (606 aa), FASTA scores: opt: 1420, E(): 3.8e-74, (43.35% identity in 630 aa overlap); Q9ZJV6|NUOL|JHP1192 from Helicobacter pylori J99 (Campylobacter pylori J99) (612 aa), FASTA scores: opt: 1279, E(): 4.7e-66, (41.65% identity in 516 aa overlap); etc. Also similar to MTCY251.04 (FASTA score: E(): 1.3e-11) and MTCY03A2.01c (FASTA score: E(): 2.3e-10). SIMILAR TO POLYPEPTIDE 5 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIAL. TBparse score is 0.892." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN L) NUOL (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN L)" /protein_id="CAA16667.1" /db_xref="GI:3242279" /db_xref="GOA:O86350" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003916" /db_xref="InterPro:IPR003945" /db_xref="UniProtKB/Swiss-Prot:O86350" /translation="MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAAL AAFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGV GSLIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLL IGFWYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAV LTAIGLLMLLGACAKSAQVPLQAWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPL YNLAPTAQLAVVIVGAVTLLFGAIIGCAKDDIKRALAASTISQIGYMVLAAGLGPAGY AFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAI IGVPPFAGFFSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKR WTPGAHPHEAPAVMTWPMILLAVGSVFSGGLLAVGGTLRHWLQPVVGSHEEATHALPT WVATTLALGVVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFNEEVFMR PGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVA AALLVVQLW" gene 56469..58130 /gene="nuoM" /locus_tag="Rv3157" CDS 56469..58130 /gene="nuoM" /locus_tag="Rv3157" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3157, (MTCY03A2.01c-MTV014.01c), len: 553 aa. Probable nuoM, integral membrane NADH dehydrogenase I, chain M (EC 1.6.5.3), similar to others e.g. Q9XAR6|NUOM from Streptomyces coelicolor (523 aa), FASTA scores: opt: 1621, E(): 4.2e-89, (56.55% identity in 541 aa overlap); P50974|NUOM_RHOCA|NUOM from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (512 aa), FASTA scores: opt: 996, E(): 6.5e-52, (38.2% identity in 521 aa overlap); P29925|NQOD_PARDE|NQO13 from Paracoccus denitrificans (513 aa), FASTA scores: opt: 987, E(): 2.2e-51, (37.05% identity in 540 aa overlap); etc. Also similar to MTCY251.04 (FASTA score: E(): 3.3e-16) and MTCY03A2.02c (FASTA score: E(): 9.6e-13). SIMILAR TO POLYPEPTIDE 4 OF THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR MITOCHONDRIAL. TBparse score is 0.883." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN M) NUOK (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN M)" /protein_id="CAA16668.1" /db_xref="GI:3242280" /db_xref="GOA:O53307" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR010227" /db_xref="UniProtKB/Swiss-Prot:O53307" /translation="MNNVPWLSVLWLVPLAGAVLIILLPPGRRRLAKWAGMVVSVLTL AVSIVVAAEFKPSAEPYQFVEKHSWIPAFGAGYTLGVDGIAVVLVLLTTVLIPLLLVA GWNDATDADDLSPASGRYPQRPAPPRLRSSGGERTRGVHAYVALTLAIESMVLMSVIA LDVLLFYVFFEAMLIPMYFLIGGFGQGAGRSRAAVKFLLYNLFGGLIMLAAVIGLYVV TAQYDSGTFDFREIVAGVAAGRYGADPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAA VESTPATAVLMMAVMDKVGTFGMLRYCLQLFPDPSTYFRPLIVTLAIIGVIYGAIVAI GQTDMMRLIAYTSISHFGFIIAGIFVMTTQGQSGSTLYMLNHGLSTAAVFLIAGFLIA RRGSRSIADYGGVQKVAPILAGTFMVSAMATVSLPGLAPFISEFLVLLGTFSRYWLAA AFGVTALVLSAVYMLWLYQRVMTGPVAEGNERIGDLVGREMIVVAPLIALLLVLGVYP KPVLDIINPAVENTMTTIGQHDPAPSVAHPVPAVGASRTAEGPHP" gene 58127..59722 /gene="nuoN" /locus_tag="Rv3158" CDS 58127..59722 /gene="nuoN" /locus_tag="Rv3158" /EC_number="1.6.5.3" /function="INVOLVED IN AEROBIC|ANAEROBIC RESPIRATION [CATALYTIC ACTIVITY: NADH + UBIQUINONE = NAD(+) + UBIQUINOL]." /experiment="experimental evidence, no additional details recorded" /note="Rv3158, (MTV014.02c), len: 531 aa. Probable nuoN, integral membrane NADH dehydrogenase I, chain N (EC 1.6.5.3), similar to others e.g. Q9XAR7|SC10A7.08c from Streptomyces coelicolor (552 aa), FASTA scores: opt: 1493, E(): 1.1e-81, (56.7% identity in 543 aa overlap); Q9PGI2|XF0318 from Xylella fastidiosa (485 aa), FASTA scores: opt: 942, E(): 7.4e-49, (39.6% identity in 379 aa overlap); CAB51628|NUON2 from Rhizobium meliloti (Sinorhizobium meliloti) (479 aa), FASTA scores: opt: 934, E(): 2.2e-48, (35.5% identity in 479 aa overlap); etc. But also similarity with NADH-PLASTOQUINONE OXIDOREDUCTASES CHAIN 4L (EC 1.6.5.3) (CATALYTIC ACTIVITY: NADH + PLASTOQUINONE = NAD(+) + PLASTOQUINOL) e.g. P29801|NU2C_SYNP7|NDHB from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (521 aa), FASTA scores: opt: 921, E(): 1.4e-47, (40.25% identity in 395 aa overlap). BELONGS TO THE COMPLEX I SUBUNIT 2 FAMILY. TBparse score is 0.901." /codon_start=1 /transl_table=11 /product="PROBABLE NADH DEHYDROGENASE I (CHAIN N) NUON (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN N)" /protein_id="CAA16623.1" /db_xref="GI:2827568" /db_xref="GOA:P0A5M0" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR010096" /db_xref="UniProtKB/Swiss-Prot:P0A5M0" /translation="MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVT LALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAE RSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSV GGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFF LYGVALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPD VYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVT AVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLV RGADGSAGSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAA SAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEESGDTPHVAAPGVLSKAAIAVCTVV TVVLGIAPQPVLDLADQAAQLLR" gene complement(59728..61500) /gene="PPE53" /locus_tag="Rv3159c" CDS complement(59728..61500) /gene="PPE53" /locus_tag="Rv3159c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3159c, (MTV014.03c), len: 590 aa. Member of the Mycobacterium tuberculosis PPE_family of Gly-, Asn-rich proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 2289, E(): 3.2e-98, (63.5% identity in 600 aa overlap); and also similar to MTCY48_17, MTV041_29, MTCY6G11_5, MTCY98_24, etc. TBparse score is 0.921." /codon_start=1 /transl_table=11 /product="PPE FAMILY PROTEIN" /protein_id="CAE55561.1" /db_xref="GI:38490332" /db_xref="InterPro:IPR000030" /db_xref="InterPro:IPR002989" /db_xref="UniProtKB/TrEMBL:Q6MX04" /translation="MNYSVLPPEINSLRMFTGAGSAPMLAASVAWDRLAAELAVAASS FGSVTSGLAGQSWQGAAAAAMAAAAAPYAGWLAAAAARAAGASAQAKAVASAFEAARA ATVHPMLVAANRNAFVQLVLSNLFGQNAPAIAAAEAMYEQMWAADVAAMVGYHGGASA AAAQLSSWSIGLQQALPAAPSALAAAIGLGNIGVGNLGGGNTGDYNLGSGNSGNANVG SGNSGNANVGSGNDGATNLGSGNIGNTNLGSGNVGNVNLGSGNRGFGNLGNGNFGSGN LGSGNTGSTNFGGGNLGSFNLGSGNIGSSNIGFGNNGDNNLGLGNNGNNNIGFGLTGD NLVGIGALNSGIGNLGFGNSGNNNIGFFNSGNNNVGFFNSGNNNFGFGNAGDINTGFG NAGDTNTGFGNAGFFNMGIGNAGNEDMGVGNGGSFNVGVGNAGNQSVGFGNAGTLNVG FANAGSINTGFANSGSINTGGFDSGDRNTGFGSSVDQSVSSSGFGNTGMNSSGFFNTG NVSAGYGNNGDVQSGINNTNSGGFNVGFYNSGAGTVGIANSGLQTTGIANSGTLNTGV ANTGDHSSGGFNQGSDQSGFFGQP" gene complement(61675..62316) /locus_tag="Rv3160c" CDS complement(61675..62316) /locus_tag="Rv3160c" /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3160c, (MTV014.04c), len: 213 aa. Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR PROTEIN (global repressor in the nitrogen regulation system; see Jakoby et al., 2000) (222 aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity in 208 aa overlap); Q9X7X9|SC6A5.33c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (223 aa), FASTA scores: opt: 176, E(): 0.00018, (26.5% identity in 185 aa overlap); Q9XA31|SCH69.03c PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (209 aa), FASTA scores: opt: 173, E(): 0.00027, (27.25% identity in 176 aa overlap); BAB54133|MLL7734 TRANSCRIPTIONAL REGULATOR from Rhizobium loti (Mesorhizobium loti) (213 aa), FASTA scores: opt: 172, E(): 0.00031, (23.55% identity in 204 aa overlap); etc. Also similar to hypothetical proteins from Mycobacterium tuberculosis strain H37Rv e.g. P96839|Rv3557v|MTCY06G11.04c (200 aa), FASTA scores: opt: 169, E(): 0.00046, (26.75% identity in 157 aa overlap). Contains probable helix-turn-helix motif from aa 31 to 52 (Score 1857, +5.51 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.901." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)" /protein_id="CAA16625.1" /db_xref="GI:2827570" /db_xref="GOA:O53310" /db_xref="InterPro:IPR001647" /db_xref="UniProtKB/TrEMBL:O53310" /translation="MPRQAGRWSPTALRILGAAAELIALRGYSSTSTRDIAAAVGVEQ PAIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVPAVVKLHRWLTESLDHLHASP YVLVSILITPDLHQESFVAERELVAEMERALVGLIETGQGEGDVRAMHPLSAARLVQA LFDALALPEFAVSPDEIVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL" gene complement(62327..63475) /locus_tag="Rv3161c" CDS complement(62327..63475) /locus_tag="Rv3161c" /EC_number="1.-.-.-" /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3161c, (MTV014.05c), len: 382 aa. Possible dioxygenase (EC 1.-.-.-), similar to subunit of several dioxygenases and related proteins e.g. BAB50510|MLR3662 DIOXYGENASE, ALPHA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (400 aa), FASTA scores: opt: 413, E(): 6.2e-20, (28.4% identity in 331 aa overlap); Q9A3T0|CC3122 RIESKE 2FE-2S FAMILY PROTEIN from Caulobacter crescentus (404 aa), FASTA scores: opt: 405, E(): 2.1e-19, (27.95% identity in 372 aa overlap); Q9HTF4|PA5410 PROBABLE RING HYDROXYLATING DIOXYGENASE, ALPHA-SUBUNIT from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 392, E(): 1.6e-18, (25.8% identity in 399 aa overlap); Q9AGK6|PHTAA PHTHALATE DIOXYGENASE LARGE SUBUNIT from Arthrobacter keyseri (473 aa), FASTA scores: opt: 385, E(): 5.2e-18, (34.0% identity in 206 aa overlap); P76253|YEAW_ECOLI PUTATIVE DIOXYGENASE, ALPHA SUBUNIT from Escherichia coli (374 aa), FASTA scores: opt: 376, E(): 1.7e-17, (27.05% identity in 344 aa overlap); etc. TBparse score is 0.932." /codon_start=1 /transl_table=11 /product="POSSIBLE DIOXYGENASE" /protein_id="CAA16626.1" /db_xref="GI:2827571" /db_xref="GOA:O53311" /db_xref="InterPro:IPR001663" /db_xref="InterPro:IPR005806" /db_xref="UniProtKB/TrEMBL:O53311" /translation="MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQLE RERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHALSPICRHRLMLM VEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDFNRRECRLPQFAVATWNGLVW INLDADAEPIAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLG LHRQTLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKSNLVVLWTFP NSALAIAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDED RLGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS" gene complement(63545..63982) /locus_tag="Rv3162c" CDS complement(63545..63982) /locus_tag="Rv3162c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3162c, (MTV014.06c), len: 145 aa. Possible integral membrane protein, with some similarity to C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical protein from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa overlap); and other hypothetical proteins from other organisms. TBparse score is 0.924." /codon_start=1 /transl_table=11 /product="POSSIBLE INTEGRAL MEMBRANE PROTEIN" /protein_id="CAA16627.1" /db_xref="GI:2827572" /db_xref="UniProtKB/TrEMBL:O53312" /translation="MTSFAHPGTRGLSTVFGLMMVGSAAVGSHGLAVVVGLAAVIAVG VAAVFRLAATLAVVLSVVMIVVSGPTHVLAALSGFCAAVYLVCRYGAGVVAGSWPTTV AAVGFTFAGLAATSFPLQVPWLPLAAPLAVLATYVLATRPFSR" gene complement(63979..65250) /locus_tag="Rv3163c" CDS complement(63979..65250) /locus_tag="Rv3163c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3163c, (MTV014.07c), len: 423 aa. Possible conserved secreted protein, with some similarity to other hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from Streptomyces coelicolor (460 aa), FASTA scores: opt: 666, E(): 1.5e-33, (33.55% identity in 417 aa overlap); O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa), FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity in 389 aa overlap); etc. Also some similarity with P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium tuberculosis (317 aa), FASTA scores: opt: 198, E(): 6.3e-05, (26.75% identity in 269 aa overlap). Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature." /codon_start=1 /transl_table=11 /product="POSSIBLE CONSERVED SECRETED PROTEIN" /protein_id="CAA16628.1" /db_xref="GI:2827573" /db_xref="InterPro:IPR002881" /db_xref="UniProtKB/TrEMBL:O53313" /translation="MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAA PLLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALA GMQFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPL TPPQSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLH VTRRLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGG NRPRWLGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTE FALALIDLRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLS WPADHSLQQSMGALPNRRRRGRGRASRARLP" misc_feature complement(64774..64860) /locus_tag="Rv3163c" /note="PS00402 Binding-protein-dependent transport systems inner membrane comp signature" gene complement(65280..66242) /gene="moxR3" /locus_tag="Rv3164c" CDS complement(65280..66242) /gene="moxR3" /locus_tag="Rv3164c" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM; REGULATES METHANOL DEHYDROGENASE." /note="Rv3164c, (MTV014.08c), len: 320 aa. Probable moxR3, methanol dehydrogenase regulatory protein, highly similar to Q9Z538|SC9B2.21c PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (332 aa), FASTA scores: opt: 1227, E(): 1.7e-67, (60.25% identity in 302 aa overlap); Q9UZ67|MOXR-3|PAB0848 METHANOL DEHYDROGENASE REGULATORY PROTEIN from Pyrococcus abyssi (314 aa), FASTA scores: opt: 1126, E(): 2.3e-61, (54.1% identity in 305 aa overlap); Q9HSH7|MOXR|VNG0223G METHANOL DEHYDROGENASE REGULATORY PROTEIN from Halobacterium sp. strain NRC-1 (318 aa), FASTA scores: opt: 1072, E(): 4.5e-58, (51.45% identity in 315 aa overlap); Q9RVV4|DR0918 MOXR-RELATED PROTEIN from Deinococcus radiodurans (354 aa), FASTA scores: opt: 1000, E(): 1.2e-53, (50.95% identity in 318 aa overlap); etc. Also high similarity with several hypothetical bacterial proteins. TBparse score is 0.917." /codon_start=1 /transl_table=11 /product="PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN MOXR3" /protein_id="CAA16629.1" /db_xref="GI:2827574" /db_xref="InterPro:IPR011703" /db_xref="UniProtKB/TrEMBL:O53314" /translation="MIMPAATTTAHCEAVLDEIERVVVGKRSALTLILTAVLARGHVL IEDLPGLGKTLIARSFAAALGLDFTRVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPI FTNLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTY PLPEAQLDRFAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVE QVTVHEDVLHYVVSLANATRHHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDV KELATAAVAHRITLRPEMWVRKIAGADVVSELLRRLPVPRISGT" gene complement(66250..66732) /locus_tag="Rv3165c" CDS complement(66250..66732) /locus_tag="Rv3165c" /function="UNKNOWN" /note="Rv3165c, (MTV014.09)c, len: 160 aa. Hypothetical unknown protein. TBparse score is 0.928." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAA16630.1" /db_xref="GI:2827575" /db_xref="UniProtKB/TrEMBL:O53315" /translation="MKRLIALGIFLIVGIELLALILHDRRLVLAGSGLALALVLLNVR RMLGNRDELTAAPDSDDLGEGLRRWLSNTETTIRWSESTRADWDRHLRPMLARRFEIA TGHRQAKDPVAFAATGRMLFGDELWEWVNPNNVTHTGDRQPGPGRAALEEILQKLEQV " gene complement(66729..67688) /locus_tag="Rv3166c" CDS complement(66729..67688) /locus_tag="Rv3166c" /function="UNKNOWN" /note="Rv3166c, (MTV014.10c), len: 319 aa. Probable transmembrane protein, similar but longer (52 aa) to O32895|MLCB1779.35c hypothetical protein from Mycobacterium leprae (119 aa), FASTA scores: opt: 289, E(): 3.7e-10, (44.25% identity in 122 aa overlap). Also some similarity to Q9Z536|SC9B2.23c PUTATIVE TRANSMEMBRANE PROTEIN from Streptomyces coelicolor (339 aa), FASTA scores: opt: 247, E(): 2.5e-07, (28.2% identity in 326 aa overlap); and in N-terminus to Q9RS20|DR2307 PUTATIVE MULTIDRUG-EFFLUX TRANSPORTER from Deinococcus radiodurans (410 aa), FASTA scores: opt: 135,E(): 1, (32.35% identity in 136 aa overlap). TBparse score is 0.934." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16631.1" /db_xref="GI:2827576" /db_xref="UniProtKB/TrEMBL:O53316" /translation="MPGTKPGSDKPTGRVVVVIVLLMLAGAALRGHLPADDGAPLAAA GGSRAALMFIVAALAATLALIALAIITRLRHPLPVAPSAGELSAMLGGAAGRPNWRVL LLGLGTILAWLLIAILLARLFVPDDVGPAAPIPDSTATPDASSTTPSRPQPPQDNNDD VLGILFASTIGLFLMVVAGSLITSRRQRKSAPARISGDRIESPAPSARSESLARAAEI GLAEMADLRREPREAIIACYVAMERELSHVPGVAPQDFDTPTEVLARAVEHRALHGAS AAALVSLFAEARFSPHVMNEEHREVAMRLLRLVLDELSTRTAI" gene complement(67768..68394) /locus_tag="Rv3167c" CDS complement(67768..68394) /locus_tag="Rv3167c" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /note="Rv3167c, (MTV014.11c), len: 208 aa. Probable transcriptional regulator, tetR family, similar to several transcriptional regulators e.g. Q9L2A4|SC8F4.22c (TETR/ACRR FAMILY) from Streptomyces coelicolor (234 aa), FASTA scores: opt: 317, E(): 7.5e-13, (33.35% identity in 210 aa overlap); Q9RK47|SCF12.11 (TETR/ACRR FAMILY) from Streptomyces coelicolor (206 aa), FASTA scores: opt: 293, E(): 2.1e-11, (32.65% identity in 199 aa overlap); Q54288 REGULATOR OF ANTIBIOTIC TRANSPORT COMPLEXES (TETR/ACRR FAMILY) (204 aa), FASTA scores: opt: 260, E(): 2.4e-09, (30.75% identity in 205 aa overlap); etc. Equivalent to AAK47595 from Mycobacterium tuberculosis strain CDC1551 but shorter 21 aa. Contains probable helix-turn-helix motif from aa 42 to 63 (Score 1727, +5.07 SD). MAY BE BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.871." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)" /protein_id="CAA16632.1" /db_xref="GI:2827577" /db_xref="GOA:O53317" /db_xref="InterPro:IPR001647" /db_xref="UniProtKB/TrEMBL:O53317" /translation="MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSL AAVAERAGTTKSALYRRWSSKAELVHEAAFPAAPTALQAAAGDIAADIRMMIAATRDV FTTPVVRAALPGLVADMTADAELNARVLARFADLFAAVRMRLREAVDRGEAHPDVDPD RLIELIGGATMLRMLLYPDDMLDDAWVDQTTAIVVRGVHRAAPGGSVV" gene 68439..69575 /locus_tag="Rv3168" CDS 68439..69575 /locus_tag="Rv3168" /function="UNKNOWN" /note="Rv3168, (MTV014.12), len: 378 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. Q9M7Y6|F3E22.6 from Arabidopsis thaliana (Mouse-ear cress) (314 aa), FASTA scores: opt: 236, E(): 1.1e-07, (27.35% identity in 234 aa overlap); Q9RYW2|DRA0194 from Deinococcus radiodurans (386 aa), FASTA scores: opt: 207, E(): 9.1e-06, (23.45% identity in 320 aa overlap); etc. Also some similarity with O69727|Rc3761c|MTV025.109c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (351 aa), FASTA scores: opt: 193, E(): 6.4e-05, (29.4% identity in 242 aa overlap). TBparse score is 0.907." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16633.1" /db_xref="GI:2827578" /db_xref="GOA:O53318" /db_xref="InterPro:IPR002575" /db_xref="UniProtKB/TrEMBL:O53318" /translation="MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVT VESGVDSTGMSSETIILTARWQQDGRSIQQKLVARVAPAAEDVPVFPTYRLDHQFEVI RLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAE RQRQLQDATVAALATLHSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIG RSPLLERTFEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWEMVALGPR ELDVAWMIFAHRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSG VMWACVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH" gene 69575..70699 /locus_tag="Rv3169" CDS 69575..70699 /locus_tag="Rv3169" /function="UNKNOWN" /note="Rv3169, (MTV014.13), len: 374 aa. Conserved hypothetical protein, with similarity to other hypothetical proteins: Q9A8W6|CC1232 from Caulobacter crescentus (368 aa), FASTA scores: opt: 669, E(): 3.3e-34, (34.05% identity in 376 aa overlap); and O32901|MLCB1779.41 from Mycobacterium leprae (127 aa), FASTA scores: opt: 179, E(): 0.00034, (29.0% identity in 131 aa overlap). Also weak similarity with P95149|Rv1866|MTCY359.07c (804 aa), FASTA scores: opt: 121, E(): 6.4, (37.0% identity in 119 aa overlap). Equivalent to AAK47597 from Mycobacterium tuberculosis strain CDC1551 but shorter 43 aa. TBparse score is 0.890." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16634.1" /db_xref="GI:2827579" /db_xref="UniProtKB/TrEMBL:O53319" /translation="MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGN IFLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLR KLRIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVD GERIAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLI IQEEPDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVH FDVESKLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHV GRALCRDGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP" misc_feature 70839..70859 /note="PS00092 N-6 Adenine-specific DNA methylases signature" gene 70842..72188 /gene="aofH" /locus_tag="Rv3170" CDS 70842..72188 /gene="aofH" /locus_tag="Rv3170" /EC_number="1.4.3.4" /function="POSSIBLY CATALYZES THE OXIDATIVE DEAMINATION: OXIDIZE ON PRIMARY AMINES, AND PERHAPS ON SECONDARY AND TERTIARY AMINES [CATALYTIC ACTIVITY: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)]. MUST HAVE IMPORTANT FUNCTION IN METABOLISM. SUPPOSED INVOLVED IN STATIONARY-PHASE SURVIVAL." /experiment="experimental evidence, no additional details recorded" /note="Rv3170, (MT3259, MTV014.14), len: 448 aa. Probable aofH, flavin-containing (mono)amine oxidase (EC 1.4.3.4), equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and similar to many eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY from Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) (522 aa), FASTA scores: opt: 869, E(): 5.3e-44, (37.7% identity in 448 aa overlap); P21396|AOFA_RAT|MAOA from Rattus norvegicus (Rat) (526 aa), FASTA scores: opt: 839, E(): 3.2e-42, (37.45% identity in 446 aa overlap); Q99NA8|MAO-A from Cavia porcellus (Guinea pig) (506 aa), FASTA scores: opt: 836, E(): 4.6e-42, (37.0% identity in 446 aa overlap); P21398|AOFA_BOVIN from Bos taurus (Bovine) (527 aa), FASTA scores: opt: 806, E(): 2.8e-40, (37.0% identity in 446 aa overlap); P21397|AOFA_HUMAN (527 aa), FASTA scores: opt: 801, E(): 5.6e-40, (37.2% identity in 446 aa overlap); etc. Alternative start possible at position 3538487. BELONGS TO THE FLAVIN MONOAMINE OXIDASE FAMILY. COFACTOR: FAD (POTENTIAL). TBparse score is 0.900." /codon_start=1 /transl_table=11 /product="PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE OXIDASE) (MAO)" /protein_id="CAA16635.1" /db_xref="GI:2827580" /db_xref="GOA:P63533" /db_xref="UniProtKB/Swiss-Prot:P63533" /translation="MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYR GTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATS SSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQDRVPGGTQQI AQAAAAQLGARVLLNAAVRRIDRHGAGVTVTSDQGQAEAGFVIVAIPPAHRVAIEFDP PLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADG PGILMGFVDARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGP TAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVAALL" gene complement(72183..73082) /gene="hpx" /locus_tag="Rv3171c" CDS complement(72183..73082) /gene="hpx" /locus_tag="Rv3171c" /EC_number="1.11.1.-" /function="SUPPOSED INVOLVED IN DETOXIFICATION REACTIONS." /note="Rv3171c, (MTV014.15c), len: 299 aa. Possible hpx, non-heme haloperoxidase (EC 1.11.1.-), similar to other hydrolases (principaly epoxide hydrolases) and non-heme chloroperoxidases e.g. Q9RKB6|SCE87.22c PUTATIVE HYDROLASE from Streptomyces coelicolor (314 aa), FASTA scores: opt: 431, E(): 6e-20, (38.05% identity in 297 aa overlap); Q9HZ14|PA3226 PROBABLE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 236, E(): 1e-07, (29.6% identity in 277 aa overlap); Q9DBL9|1300003 D03RIK PROTEIN SIMILAR TO ALPHA/BETA HYDROLASE FOLD from Mus musculus (Mouse) (351 aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35% identity in 304 aa overlap); AAK46260|MT1988 EPOXIDE HYDROLASE from Mycobacterium tuberculosis strain CDC1551 (356 aa), FASTA scores: opt: 223, E(): 8.4e-07, (40.7% identity in 113 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) from Streptomyces lividans (275 aa), FASTA scores: opt: 220, E(): 1e-06, (29.5% identity in 305 aa overlap); etc. Equivalent to AAK47599 Hydrolase, alpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 but shorter 24 aa. Start chosen by similarity, alternative with good RBS possible. TBparse score is 0.907." /codon_start=1 /transl_table=11 /product="POSSIBLE NON-HEME HALOPEROXIDASE HPX" /protein_id="CAA16636.1" /db_xref="GI:2827581" /db_xref="GOA:O53321" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000379" /db_xref="InterPro:IPR003089" /db_xref="UniProtKB/TrEMBL:O53321" /translation="MTVRAADGTPLHTQVFGPPHGYPIVLTHGFVCAIRAWAYQIADL AGDYRVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAGHSMGGI TIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELSPVRVLAGRSLVNTF GGFPLPGAARALSRHVISTLAVAADADPSATRLVYELFTQTSAAGRGGCAKMLVEEVG SAHLNLDGLTVPTLVIGGVRDRLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQE VNSHLRALAESVTRHVRDRRISS" gene complement(73219..73701) /locus_tag="Rv3172c" CDS complement(73219..73701) /locus_tag="Rv3172c" /function="UNKNOWN" /note="Rv3172c, (MTV014.16c), len: 160 aa. Hypothetical unknown protein." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAA16637.1" /db_xref="GI:2827582" /db_xref="UniProtKB/TrEMBL:O53322" /translation="MSVALLREMFDRMVVAKNAELIEHYYDPDFLMYSDGLSQSFAKF RDSHRKLYATAISYAVEYDEHAWVEAQTRLPGGCGSPRRDLARSRPASRWYSLPPTAT AEFTGSGRRRGRVGATWPPSTITETTTDRLAMRNQLRAGAATLLFCDPMLQRFPATRK " gene complement(73780..74382) /locus_tag="Rv3173c" CDS complement(73780..74382) /locus_tag="Rv3173c" /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM (PROBABLY REPRESSION)." /note="Rv3173c, (MTV014.17c), len: 200 aa. Probable transcriptional regulatory protein tetR family, similar to several bacterial putative regulatory proteins e.g. Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195 aa), FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity in 195 aa overlap); O85695|3SCF60.04 from Streptomyces lividans and Streptomyces coelicolor (192 aa), FASTA scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa overlap); BAB50853|MLR4117 from Rhizobium loti (Mesorhizobium loti) (205 aa), FASTA scores: opt: 280, E(): 5.5e-11, (31.45% identity in 194 aa overlap); BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti) (194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05% identity in 185 aa overlap); etc. Also similar to other regulators from Mycobacterium tuberculosis e.g. P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt: 154, E(): 0.0013, (38.8% identity in 80 aa overlap). Contains probable helix-turn-helix motif from aa 39 to 60 (Score 1251, +3.45 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.925." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY)" /protein_id="CAA16638.1" /db_xref="GI:2827583" /db_xref="GOA:O53323" /db_xref="InterPro:IPR001647" /db_xref="UniProtKB/TrEMBL:O53323" /translation="MPPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATGVELIA NKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGEADKMPKASNATPRERLLALFDRPN RGDGRMRGCPFHNAAVEAAGEMPGVERIVHSHKRDYIKGLARLAREAGAAHPRSLGNQ LAVLFEGAAALSTSLDDAGPWAHARAAAEVLIDQATARPV" gene 74475..75182 /locus_tag="Rv3174" CDS 74475..75182 /locus_tag="Rv3174" /EC_number="1.-.-.-" /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM." /note="Rv3174, (MTV014.18), len: 235 aa. Probable oxidoreductase short-chain dehyrogenase/reductase (EC 1.-.-.-), similar to others e.g. Q9RPT7|SITS from Streptomyces albus (223 aa), FASTA scores: opt: 654, E(): 6.1e-32, (49.3% identity in 215 aa overlap); Q9RI61|SCJ11.46 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 626, E(): 2.9e-30, (50.9% identity in 224 aa overlap); Q9A5Z1|CC2306 from Caulobacter crescentus (252 aa), FASTA scores: opt: 430, E(): 1.3e-18, (39.45% identity in 228 aa overlap); Q51641 INSECT-TYPE DEHYDROGENASE (249 aa), FASTA scores: opt: 301, E(): 5.7e-11, (38.3% identity in 188 aa overlap); Q9HXC9|PA3883 from Pseudomonas aeruginosa (276 aa), FASTA scores: opt: 296, E(): 1.2e-10, (29.55% identity in 247 aa overlap); etc. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. TBparse score is 0.900." /codon_start=1 /transl_table=11 /product="PROBABLE SHORT-CHAIN DEHYDROGENASE/REDUCTASE" /protein_id="CAA16639.1" /db_xref="GI:2827584" /db_xref="GOA:O53324" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR002347" /db_xref="UniProtKB/TrEMBL:O53324" /translation="MTSLAERTVLVTGANRGMGREYVAQLLGRKVAKVYAATRNPLAI DVSDPRVIPLQLDVTDAVSVAEAADLATDVGILINNAGISRASSVLDKDTSALRGELE TNLFGPLALASAFADRIAERSGAIVNVSSVLAWLPLGMSYGVSKAAMWSATESMRIEL APRGVQVVGVYVGLVDTDMGRFADAPKSDPADVVRQVLDGIEAGKEDVLADEMSRQVR ASLNVPARERIARLMGN" gene 75197..76684 /locus_tag="Rv3175" CDS 75197..76684 /locus_tag="Rv3175" /EC_number="3.5.1.-" /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM." /note="Rv3175, (MTV014.19), len: 495 aa. Possible amidase (EC 3.5.1.-), similar to others e.g. Q9F6D0|ZHUL ENANTIOMER SELECTIVE AMIDASE from Streptomyces sp. R1128 (507 aa), FASTA scores: opt: 1328 ,E(): 7.5e-69, (44.5% identity in 492 aa overlap); BAB51815|MLR5350 PROBABLE AMIDASE from Rhizobium loti (Mesorhizobium loti) (457 aa), FASTA scores: opt: 7487, E(): 1.3e-35, (35.9% identity in 482 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE (EC 3.5.1.4) from Archaeoglobus fulgidus (453 aa), FASTA scores: opt: 532, E(): 3.2e-23, (32.05% identity in 471 aa overlap); etc. But also similar to glutamyl-tRNA amidotransferases who belong to amidase family e.g. Q9RTA9|DR1856 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE, SUBUNIT A from Deinococcus radiodurans (482 aa), FASTA scores: opt: 560, E(): 8.2e-25, (30.6% identity in 513 aa overlap); Q9LCX3|GATA GLU/ASP-TRNA AMIDOTRANSFERASE SUBUNIT A from Thermus aquaticus (subsp. thermophilus) (471 aa), FASTA scores: opt: 558, E(): 1.1e-24, (30.85% identity in 486 aa overlap); Q49091|GATA_MORCA GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A (EC 6.3.5.-) from Moraxella catarrhalis (492 aa), FASTA scores: opt: 526, E(): 7.5e-23, (30.45% identity in 473 aa overlap); etc. SEEMS TO BELONG TO THE AMIDASE FAMILY. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.901." /codon_start=1 /transl_table=11 /product="POSSIBLE AMIDASE (AMINOHYDROLASE)" /protein_id="CAA16640.1" /db_xref="GI:2827585" /db_xref="GOA:O53325" /db_xref="InterPro:IPR000120" /db_xref="UniProtKB/TrEMBL:O53325" /translation="MAMSAKASDDIAWLPATAQLAVLAAKKVSSAELVELYLSRIDTY NASLNAIVTVDPDAARRVAKRSDAARARGDELGPLHGLPITVKDSYETAGMRTTCGRR DLADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSG GSAGGGAAATAAGLTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGN PGRWGQADMACAGVQVRGARDIIPALEATVGPMRADGGFSYALAPPRAGALKDFRVAV WAEDPHCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFA VDRSTLSPASAAALGLRAVRHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFF NEFDVLLLPVTPTPAPLHHNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATT MPITTTATGLPIGIQAMGPAGGDRTTVEFAALLTEVLGGFRVPPL" misc_feature 75563..75586 /locus_tag="Rv3175" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene complement(76681..77637) /gene="mesT" /locus_tag="Rv3176c" CDS complement(76681..77637) /gene="mesT" /locus_tag="Rv3176c" /EC_number="3.3.2.3" /function="BIOTRANSFORMATION ENZYME THAT ACTS ON A VARIETY OF EPOXIDES AND ARENE OXIDES. CATALYZES THE HYDROLYSIS OF ARENE AND EPOXIDES TO LESS REACTIVE AND MORE WATER SOLUBLE DIHYDRODIOLS BY THE TRANS ADDITION OF WATER [CATALYTIC ACTIVITY: AN EPOXIDE + H(2)O = A GLYCOL]." /standard_name="lipS" /note="Rv3176c, (MTV014.20c), len: 318 aa. Probable mesT, epoxide hydrolase (EC 3.3.2.3), similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST PROTEIN (MESODERM SPECIFIC TRANSCRIPT (MOUSE) HOMOLOG) (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Homo sapiens (Human) (335 aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity in 280 aa overlap); AAH06639|Q07646 MEST PROTEIN from Mus musculus (Mouse) (335 aa), FASTA scores: opt: 342, E(): 1.4e-14, (31.45% identity in 280 aa overlap); Q9I8E7|MEST EPOXIDE HYDROLASE (EC 3.3.2.3) from Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E(): 2.7e-13, (29.55% identity in 301 aa overlap); Q9PUC9|PEG1|MEST EPOXIDE HYDROLASE from Brachydanio rerio (Zebrafish) (Zebra danio) (344 aa), FASTA scores: opt: 322, E(): 2.8e-13, (32.35% identity in 207 aa overlap); Q9HYH6|PA3429 PROBABLE EPOXIDE HYDROLASE from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 258, E(): 3e-09, (29.85% identity in 288 aa overlap); O31243|ECHA EPOXIDE HYDROLASE from Agrobacterium radiobacter (294 aa), FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in 278 aa overlap); etc. Also similar to Q50599|Rv1834|MT1882|MTCY1A11.09c HYPOTHETICAL 31.7 KDA PROTEIN from Mycobacterium tuberculosis (288 aa), FASTA scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa overlap). Equivalent to AAK47604 from Mycobacterium tuberculosis strain CDC1551 (339 aa) but shorter 21 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. MAY BE BELONG TO PEPTIDASE FAMILY S33. Note that previously known as lipS. TBparse score is 0.911." /codon_start=1 /transl_table=11 /product="PROBABLE EPOXIDE HYDROLASE MEST (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE)" /protein_id="CAE55562.1" /db_xref="GI:38490333" /db_xref="GOA:Q6MX03" /db_xref="UniProtKB/TrEMBL:Q6MX03" /translation="MTHRASALISAQEWFSAGERVGYDAERPGINPRSPLRAFIRRAA GTGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIYLDYIGHGDSDKPRDYPYSTFER ADLVEALWHAEGIAQTVVVAFDYSCIVSLELLARRIDRERAGNDQRTRITACLLANGG IFADGHTHAWYTTPLLTSPLGAAITPIGQRSWRMFAPFLRPVFSRGYPLSAAEMKELH DAISRRDGVRVLPATAGFVDEHREHAARWDLARIISALGDEVAFGVVGSAEDPFEGEQ LRLARERLADSVEITELAGGHLTTAEQPDRLAEVIAALPERS" gene 77784..78644 /locus_tag="Rv3177" CDS 77784..78644 /locus_tag="Rv3177" /EC_number="1.11.1.-" /function="SUPPOSED INVOLVED IN DETOXIFICATION REACTIONS." /note="Rv3177, (MTV014.21), len: 286 aa. Possible peroxidase (non-haem peroxidase) (EC 1.11.1.-), highly similar to Q9KJF9|W78 CULTIVAR SPECIFICITY PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) W78 from Rhizobium leguminosarum (287 aa), FASTA scores: opt: 1059, E(): 2.3e-59, (61.4% identity in 272 aa overlap); BAB48728|MLL1328 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: 746, E(): 1.1e-39, (43.25% identity in 282 aa overlap). Similar to nonheme chloroperoxidases and related esterases e.g. O73957|SAL LIPOLYTIC ENZYME from Sulfolobus acidocaldarius (314 aa), FASTA scores: opt: 408, E(): 1.9e-18, (32.4% identity in 287 aa overlap); Q9AJM9|BIOH PROTEIN INVOLVED IN BIOTIN SYNTHESIS from Kurthia sp. 538-KA26 (267 aa), FASTA scores: opt: 324 ,E(): 3.2e-13, (30.0% identity in 250 aa overlap); Q9CBB1|ML2269 PUTATIVE HYDROLASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (265 aa); O05691|THCF_RHOER NON-HEME HALOPEROXIDASE (EC 1.11.1.-) from Rhodococcus erythropolis (SIMILAR TO OTHER BACTERIAL NON-HEME BROMO- AND CHLORO-PEROXIDASES) (274 aa), FASTA scores: opt: 279, E(): 2.2e-10, (29.0% identity in 276 aa overlap); Q53540|EST ESTERASE (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Pseudomonas putida (276 aa), FASTA scores: opt: 271, E(): 7.1e-10, (29.65% identity in 280 aa overlap); etc. Also similar to O06420|BPOC|Rv0554|MTCY25D10.33 HYPOTHETICAL 28.3 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from M. tuberculosis (262 aa), FASTA scores: opt: 280 ,E(): 1.8e-10, (28.0% identity in 257 aa overlap). Equivalent to AAK47605 from Mycobacterium tuberculosis strain CDC1551 (300 aa) but shorter 14 aa. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. TBparse score is 0.913." /codon_start=1 /transl_table=11 /product="POSSIBLE PEROXIDASE (NON-HAEM PEROXIDASE)" /protein_id="CAA16642.1" /db_xref="GI:2827587" /db_xref="GOA:O53327" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000379" /db_xref="UniProtKB/TrEMBL:O53327" /translation="MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLGADAGVPVIFL HHLGAVLDNWDPRVVDGIAAKHPVVTFDNRGVGASEGQTPDTVTTMADDAIAFVRALG FDQVDLLGFSLGGFVAQVIAQQEPQLVRKIILAGTGPAGGVGIGKVTFGTIRESIKAT LTFRDPKELRFFTRTDSGKSAARQFVKRLKERKDNRDKSITVRAFRSQLKAIHAWGTQ KPSDLTSIGHPVLIANGDDDTMVPTSNSLDLADRLPDATLRIYPDAGHGGIFQHHAQF VDDALQFLES" gene 78775..79134 /locus_tag="Rv3178" CDS 78775..79134 /locus_tag="Rv3178" /function="UNKNOWN" /note="Rv3178, (MTV014.22), len: 119 aa. Hypothetical protein, with some similarity to other hypothetical bacterial proteins (principaly mycobacterium and streptomyces proteins) e.g. P71854|Rv3547|MTCY03C7.09c from Mycobacterium tuberculosis strain H37Rv (151 aa), FASTA scores: opt: 310, E(): 2e-14, (40.5% identity in 116 aa overlap); Q9ZH81 from M. paratuberculosis (144 aa), FASTA scores: opt: 274, E(): 5.6e-12, (38.9% identity in 108 aa overlap); O85698|3SCF60.07 from Streptomyces lividans and Streptomyces coelicolor (149 aa), FASTA scores: opt: 235, E(): 2.7e-09, (35.2% identity in 108 aa overlap); Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148 aa); Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa); etc. Equivalent to AAK47606 from Mycobacterium tuberculosis strain CDC1551 (171 aa) but shorter 52 aa." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16643.1" /db_xref="GI:2827588" /db_xref="GOA:O53328" /db_xref="InterPro:IPR004378" /db_xref="UniProtKB/TrEMBL:O53328" /translation="MRLGAGFRKPVPTLLLEHRSRKSGKNFVAPLLYITDRNNVIVVA SALGQAENPQWYRNLPPNPDTHIQIGSDRRPVRAVVASSDERARLWPRPVDAYADFDS CQSWTERGIPVIILRPR" gene 79955..81244 /locus_tag="Rv3179" CDS 79955..81244 /locus_tag="Rv3179" /function="UNKNOWN" /note="Rv3179, (MTV014.23), len: 429 aa. Conserved hypothetical protein, highly similar to Q9KH61 PUTATIVE ATP/GTP BINDING PROTEIN from Mycobacterium smegmatis (428 aa), FASTA scores: opt: 2466, E(): 1.5e-148, (89.7% identity in 428 aa overlap) (no article found on the NCBI web site (July 2001)); and to other hypothetical bacterial proteins e.g. O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411 aa), FASTA scores: opt: 1031, E(): 8e-58, (41.5% identity in 417 aa overlap); BAB54715|MLR9349 from Rhizobium loti (Mesorhizobium loti) (435 aa), FASTA scores: opt: 365, E(): 1.1e-15, (31.75% identity in 416 aa overlap); etc. Equivalent to AAK47609 from Mycobacterium tuberculosis strain CDC1551 (454 aa) but shorter 25 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.923." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16644.1" /db_xref="GI:2827589" /db_xref="GOA:O53329" /db_xref="UniProtKB/TrEMBL:O53329" /translation="MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQ QLHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATD RDRRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEP QVVLGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKR IEQTDRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWS RNLTAKIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAA TELEVDLYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDE FITGVLFYTGARALPFGDRLMALPINLLWNGQSVSSL" misc_feature 80051..80074 /locus_tag="Rv3179" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene complement(81591..82025) /locus_tag="Rv3180c" CDS complement(81591..82025) /locus_tag="Rv3180c" /function="UNKNOWN" /note="Rv3180c, (MTV014.24c), len: 144 aa. Hypothetical unknown ala-rich protein. Contains probable coiled-coil domain from aa 40 to 70." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL ALANINE RICH PROTEIN" /protein_id="CAA16645.1" /db_xref="GI:2827590" /db_xref="UniProtKB/TrEMBL:O53330" /translation="MPLVYFDASAFVKLLTTETGSSLASALWDGCDAALSSRLAYPEV RAALAAAARNHDLTESELADAERDWEDFWAATRPVELTATVEQHAGHLARAHALRGAD AVHLASALAVGDPGLVVAVWDRRLHTGAHAAGCRVAPAQLDP" gene complement(82028..82480) /locus_tag="Rv3181c" CDS complement(82028..82480) /locus_tag="Rv3181c" /function="UNKNOWN" /note="Rv3181c, (MTV014.25c), len: 150 aa. Hypothetical protein, with some similarity to other mycobacterium proteins e.g. Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c (99 aa), FASTA scores: opt: 123, E(): 0.25, (33.7% identity in 89 aa overlap); and O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt: 123, E(): 0.26, (39.7% identity in 68 aa overlap). TBparse score is 0.910." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16646.1" /db_xref="GI:2827591" /db_xref="InterPro:IPR006442" /db_xref="UniProtKB/TrEMBL:O53331" /translation="MQLGRKVTSHHDIDRFGVASTADESVYRPLPPRLRLAQVNLSRR RCRTQSDMYKSRFSECTVQSVDVSVTELRAHLSDWLDRARAGGEVVITERGIPIARLA ALDSTDTLERLTAEGVIGKATAQRPVAAGRPRPRPQRPVSDRVSDQRR" gene 82711..83055 /locus_tag="Rv3182" CDS 82711..83055 /locus_tag="Rv3182" /function="UNKNOWN" /note="Rv3182, (MTV014.26), len: 114 aa. Hypothetical protein, with some similarity to other hypothetical bacterial proteins e.g. O53468|Rv2022c|MTV018.09c from M. tuberculosis (201 aa), FASTA scores: opt: 335, E(): 3.6e-16, (51.9% identity in 104 aa overlap); and Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119 aa), FASTA scores: opt: 250, E(): 1.6e-10, (42.1% identity in 95 aa overlap). Equivalent to AAK47614 from Mycobacterium tuberculosis strain CDC1551 (94 aa) but longer 20 aa." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16647.1" /db_xref="GI:2827592" /db_xref="UniProtKB/TrEMBL:O53332" /translation="MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVD KVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLLGGDKAGNWKRWYDNNIPIADQR SENWLASEHGGG" gene 83052..83381 /locus_tag="Rv3183" CDS 83052..83381 /locus_tag="Rv3183" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /note="Rv3183, (MTV014.27), len: 109 aa. Possible transcriptional regulator, similar to others e.g. Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa), FASTA scores: opt: 119, E(): 0.47, (40.55% identity in 74 aa overlap); Q9X153|TM1330 from Thermotoga maritima (111 aa), FASTA scores: opt: 115, E(): 0.91, (40.35% identity in 57 aa overlap); P95258|Rv1956|MTCY09F9.08c (alias AAK46277 putative DNA-binding protein from strain CDC1551) (149 aa), FASTA scores: opt: 116, E(): 1, (42.25% identity in 71 aa overlap). Also similar to O53467|Rv2021c|MTV018.08c from Mycobacterium tuberculosis (101 aa), FASTA scores: opt: 214, E(): 5.8e-07, (43.0% identity in 107 aa overlap). Contains probable helix-turn-helix motif from aa 51 to 72 (Score 1803, +5.33 SD). TBparse score is 0.852." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN" /protein_id="CAA16648.1" /db_xref="GI:2827593" /db_xref="GOA:O53333" /db_xref="InterPro:IPR001387" /db_xref="UniProtKB/TrEMBL:O53333" /translation="MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEI RKALGHARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAEFGE NTVELTA" repeat_unit 83564..83566 /note="3 bp direct repeat, cga, at 5'-end of IS6110" repeat_region 83567..84921 /note="IS6110-12, len: 1355 bp. Insertion sequence IS6110." /insertion_seq="IS6110-12" repeat_unit 83567..83594 /note="28 bp inverted repeat at left end of IS6110, TGAACCGCCCCGGCATGTCCGGAGACTC" gene 83618..83944 /locus_tag="Rv3184" CDS 83618..83944 /locus_tag="Rv3184" /function="INVOLVED IN THE TRANSPOSITION IN THE INSERTION SEQUENCE IS6110." /note="Rv3184, (MTV014.28), len: 108 aa. Probable IS6110 transposase. TBparse score is 0.928." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA16649.1" /db_xref="GI:2827594" /db_xref="GOA:Q50686" /db_xref="InterPro:IPR002514" /db_xref="InterPro:IPR009057" /db_xref="UniProtKB/Swiss-Prot:Q50686" /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE LDRPAR" gene <83941..84879 /locus_tag="Rv3185" CDS <83941..84879 /locus_tag="Rv3185" /function="INVOLVED IN THE TRANSPOSITION IN THE INSERTION SEQUENCE IS6110." /note="Rv3185, (MTV014.29), len: 312 aa. Probable IS6110 transposase. TBparse score is 0.926." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA16650.1" /db_xref="GI:2827595" /db_xref="GOA:P19774" /db_xref="UniProtKB/Swiss-Prot:P19774" /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYD HINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTK LGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVA FVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTS IRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATAR WVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG" repeat_unit complement(84894..84921) /note="28 bp inverted repeat at right end of IS6110, TGAACCGCCCCGGTGAGTCCGGAGACTC" repeat_unit 84922..84924 /note="3 bp direct repeat, cga, at 3'-end of IS6110" repeat_unit 85047..85049 /note="3 bp direct repeat, att, at 5'-end of IS6110" repeat_region 85050..86404 /note="IS6110-13, len: 1355 bp. Insertion sequence IS6110." /insertion_seq="IS6110-13" repeat_unit 85050..85077 /note="28 bp inverted repeat at left end of IS6110, TGAACCGCCCCGGCATGTCCGGAGACTC" gene 85101..85427 /locus_tag="Rv3186" CDS 85101..85427 /locus_tag="Rv3186" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS6110." /note="Rv3186, (MTV014.30), len: 108 aa. Probable IS6110 transposase. TBparse score is 0.928." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA16651.1" /db_xref="GI:2827596" /db_xref="GOA:Q50686" /db_xref="InterPro:IPR002514" /db_xref="InterPro:IPR009057" /db_xref="UniProtKB/Swiss-Prot:Q50686" /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE LDRPAR" gene <85424..86362 /locus_tag="Rv3187" CDS <85424..86362 /locus_tag="Rv3187" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS6110." /note="Rv3187, (MTV014.31), len: 312 aa. Probable IS6110 transposase." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA16652.1" /db_xref="GI:2827597" /db_xref="GOA:P19774" /db_xref="UniProtKB/Swiss-Prot:P19774" /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYD HINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTK LGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVA FVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTS IRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATAR WVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG" repeat_unit complement(86377..86404) /note="28 bp inverted repeat at right end of IS6110, TGAACCGCCCCGGTGAGTCCGGAGACTC" repeat_unit 86405..86407 /note="3 bp direct repeat, att, at 5'-end of IS6110" gene 86635..86982 /locus_tag="Rv3188" CDS 86635..86982 /locus_tag="Rv3188" /function="UNKNOWN" /note="Rv3188, (MTV014.32), len: 115 aa. Conserved hypothetical protein, with similarity to other proteins from Mycobacterium tuberculosis: Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 HYPOTHETICAL PROTEIN (113 aa), FASTA scores: opt: 184, E(): 8.1e-06, (28.45% identity in 109 aa overlap); and O06299|Rv0348|MTCY13E10.08 HYPOTHETICAL PROTEIN (217 aa), FASTA scores: opt: 129, E(): 0.074, (30.0% identity in 100 aa overlap). Also some similarity with C-terminus of Q9XA59|SCGD3.19 PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (218 aa), FASTA scores: opt: 114, E(): 0.76, (30.0% identity in 110 aa overlap) (for this one, no similarity exists in the N-terminal region with the N-terminus of other regulatory components of sensory transduction systems). TBparse score is 0.881." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16653.1" /db_xref="GI:2827598" /db_xref="UniProtKB/TrEMBL:O53334" /translation="MAVTLDRAVEASEIVDALKPFGVTQVDVAAVIQVSDRAVRGWRT GDIRPERYDRLAQLRDLVLLLSDSLTPRGVGQWLHAKNRLLDGQRPVDLLAKDRYEDV RSAAESFIDGAYV" gene 86979..87599 /locus_tag="Rv3189" CDS 86979..87599 /locus_tag="Rv3189" /function="UNKNOWN" /note="Rv3189, (MTV014.33), len: 206 aa. Conserved hypothetical protein, weakly similar to other proteins from Mycobacterium tuberculosis e.g. O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa), FASTA scores: opt: 135, E(): 0.79, (27.8% identity in 187 aa overlap); and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186 aa), FASTA scores: opt: 122, E(): 0.85, (32.25% identity in 93 aa overlap). TBparse score is 0.881." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16654.1" /db_xref="GI:2827599" /db_xref="UniProtKB/TrEMBL:O53335" /translation="MKLADAIATAPRRTLKGTYWHQGPTRHPVTSCADPARGPGRYHR TGEPGVWYASNKEQGAWAELFRHFVDDGVDPFEVRRRVGRVAVTLQVLDLTDERTRSH LGVDETDLLSDDYTTTQAIAAARDANFDAVLAPAAALPGCQTLAVFVHALPNIEPERS EVRQPPPRLANLLPLIRPHEHMPDSVRRLLATLTRAGAEAIRRRRR" gene complement(87759..89024) /locus_tag="Rv3190c" CDS complement(87759..89024) /locus_tag="Rv3190c" /function="UNKNOWN" /note="Rv3190c, (MTV014.34c), len: 421 aa. Hypothetical unknown protein. TBparse score is 0.937." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAA16655.1" /db_xref="GI:2827600" /db_xref="UniProtKB/TrEMBL:O53336" /translation="MEYVQLFSKGRLNDLAGSLAGFLGKASQATAQRLQSWDADDLLN TPVDDVVEQLVELGSVECPDLRVDDAFMLPATEVDQQYRDWGEQRTRRVTRLVLVVPF EGHKDIFNLRPDQFTTMPPQVLRLQGHEIHLAIDNLSNDAAAINAAFHKQIANIEKYL GWSRRQIDLHNQGLRNELPGMVARRREQLLATRNLQAEIGFPVRRRKDADTYAAPISR KSVRPRPHRPAGARAAFKPEPAMQDEDYQSALRVLRNQRNALERTPSVAAKLDGEEIR DMLLVGLNAQFEGDAGGELFNGAGKTDILIRVDDRNIFIGECKVWSGPRTMDDVLKQL FGYLVWRDTKAAILLFIRNKDVTAVIDNAIAKIKEHPNHKRCPAHRAGADQYEFTMHA DGDPEREIHLTLIPFALRPTAEVPTTTIP" gene complement(89648..90682) /locus_tag="Rv3191c" CDS complement(89648..90682) /locus_tag="Rv3191c" /function="INVOLVED IN THE TRANSPOSITION OF AN INSERTION SEQUENCE." /note="Rv3191c, (MTV014.35c), len: 344 aa. Probable transposase, similar to many especially Q9K2N8 PUTATIVE TRANSPOSASE from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 837, E(): 1.3e-43, (42.55% identity in 336 aa overlap); Q9RBF4 INSERTION SEQUENCE IS1088 from Alcaligenes eutrophus (Ralstonia eutropha) (342 aa), FASTA scores: opt: 823, E(): 9.2e-43, (43.05% identity in 337 aa overlap); and Q51379 PUTATIVE TRANSPOSASE from Pseudomonas alcaligenes (338 aa), FASTA scores: opt: 818, E(): 1.8e-42, (42.35% identity in 333 aa overlap). Contains probable helix-turn-helix motif from aa 25 to 46 (Score 1968, +5.89 SD)." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA16656.1" /db_xref="GI:2827601" /db_xref="GOA:O53337" /db_xref="InterPro:IPR001584" /db_xref="UniProtKB/TrEMBL:O53337" /translation="MRQISSRYLSEEERINIADLRRSGLSIRKIADQLGRAPSTVSRE LRRNSRRDGQYRPFEAHRWAVQRRVRRHRRRIDKNPDLCELIAELLAQRWSPQQIARH LRRKYPDDRSMWLCHESIYQAVYQPQSRLIRPPQVKSPHRGPLRTGRTHRRAHLRPGR RRPRFAQPMLSIHQRPFDPADRSEPGHWEGDLIVGKNQGSAIGTLVERQTRLIRLLHL PTHDAYCLRIAITETMSDLPVTLVRSITWDQGIEMARHIDITADLGAPVYFCDSRSPW QRASNENSNGLLRQYFPKGTSLSTYTPDHLRAVEYEINNRPRQVLGHRSPAELFTALL TSPDHQLLRR" repeat_region complement(89651..90682) /note="IS1603, len: 1032 bp. Insertion sequence IS1603." /insertion_seq="IS1603" gene complement(91707..91780) /gene="tRNA-Met(CAT)" tRNA complement(91707..91780) /gene="tRNA-Met(CAT)" /product="tRNA-Met" /note="codon recognized: AUG" /anticodon=(pos:complement(91744..91746),aa:Met) gene 91900..92361 /locus_tag="Rv3192" CDS 91900..92361 /locus_tag="Rv3192" /function="UNKNOWN" /note="Rv3192, (MTV014.36), len: 153 aa. Conserved hypothetical ala- and pro-rich protein, with weak similarity to N-terminal half of several proteins e.g. Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 HYPOTHETICAL 37.3 KDA PROTEIN from Mycobacterium tuberculosis (340 aa), FASTA scores: opt: 245, E(): 3.7e-08, (33.1% identity in 157 aa overlap); O30260|AF2411 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (363 aa), FASTA scores: opt: 144, E(): 0.072, (32.6% identity in 92 aa overlap); Q9ZA30|GRA-ORF29 PUTATIVE FMN-DEPENDENT MONOOXYGENASE from Streptomyces violaceoruber (343 aa), FASTA scores: opt: 133, E(): 0.33, (25.15% identity in 159 aa overlap). TBparse score is 0.920." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL ALANINE AND PROLINE-RICH PROTEIN" /protein_id="CAA16657.1" /db_xref="GI:2827602" /db_xref="InterPro:IPR011251" /db_xref="UniProtKB/TrEMBL:O53338" /translation="MIPQPLSQLGDLARRPGRRVLCSPKTAAPSISNATVASPAAPGL ELSTGIALAFPRGPFVPAAAAWELQEATSGKFQLGLGTQVRKNVVHRYGMAFHRPGPR LRYLLAVKACFAVFQTGTPDHHGEFDNPDFITAQWSPARIDPPGPSPAGPR" gene complement(92531..95509) /locus_tag="Rv3193c" CDS complement(92531..95509) /locus_tag="Rv3193c" /function="UNKNOWN" /note="Rv3193c, (MTV014.37c), len: 992 aa. Probable conserved transmembrane protein, with hydrophobic N-terminal domain (~1-340 aa), highly similar to Q9CCM6|ML0644 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Mycobacterium leprae (983 aa), FASTA scores: opt: 5421, E(): 0, (86.15% identity in 989 aa overlap); and O53609|Rv0064|MTV030.07 PUTATIVE MEMBRANE PROTEIN from Mycobacterium tuberculosis strain H37Rv (979 aa), FASTA scores: opt: 3204, E(): 2.1e-142, (50.25% identity in 985 aa overlap). C-terminal part (709-990 aa) highly similar to O32904|MLCB1779.46 HYPOTHETICAL 29.1 KDA PROTEIN from Mycobacterium leprae (277 aa), FASTA scores: opt: 1521, E(): 3.4e-64, (82.6% identity in 282 aa overlap). Also some similarity to hypothetical proteins generally transmembrane e.g. Q9FCI4|2SC3B6.28 from Streptomyces coelicolor (815 aa), FASTA scores: opt: 951, E(): 3.4e-37, (39.2% identity in 826 aa overlap); P72637|SLL1060 from Synechocystis sp. strain PCC 6803 (1032 aa), FASTA scores: opt: 938, E(): 1.6e-36, (29.95% identity in 855 aa overlap); O28851|AF1421 from Archaeoglobus fulgidus (880 aa), FASTA scores: opt: 526, E(): 2.6e-17, (28.05% identity in 970 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" /protein_id="CAA16658.1" /db_xref="GI:2827603" /db_xref="GOA:O53339" /db_xref="InterPro:IPR005372" /db_xref="UniProtKB/Swiss-Prot:O53339" /translation="MGMRSAARMPKLTRRSRILIMIALGVIVLLLAGPRLIDAYVDWL WFGELGYRSVFTTMLATRIVVCLVAGVVVGGIVFGGLALAYRTRPVFVPDADNDPVAR YRAVVLARLRLVGIGIPAAIGLLAGIVAQSYWARIQLFLHGGDFGVRDPQFGRDLGFY AFELPFYRLMLSYMLVSVFLAFVANLVAHYIFGGIRLSGRTGALSRSARVQLVSLVGV LVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAAAVFSA IALRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSITATRQA YGLTSDVVTYRNYSGDSPATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYF PDQLSIDRYLDRNGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANT VRGIANDPNQNGGYPEFLVNVVGANGTVVSDGPAPLDQPRIYFGPVISNTSADYAIVG RNGDDREYDYETNIDTKRYTYTGSGGVPLGGWLARSVFAAKFAERNFLFSNVIGSNSK ILFNRDPAQRVEAVAPWLTTDSAVYPAIVNKRLVWIVDGYTTLDNYPYSELTSLSSAT ADSNEVAFNRLVPDKKVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMQVFPGTV KPKSDIAPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASS YQPPYYIVAKNIAKDDNSASYQLISAMNRFKRDYLAAYISASSDPATYGNLTVLTIPG QVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVARGGLLYVEPVYASP GASDAASSYPRLIRVAMMYNDKVGYGPTVRDALTGLFGPGAGATATGIAPTEAAVPPS PAANPPPPASGPQPPPVTAAPPVPVGAVTLSPAKVAALQEIQAAIGAARDAQKKGDFA AYGSALQRLDEAITKFNDAG" gene complement(95601..96623) /locus_tag="Rv3194c" CDS complement(95601..96623) /locus_tag="Rv3194c" /function="UNKNOWN" /note="Rv3194c, (MTV014.38c), len: 340 aa. Possible conserved secreted protein (N-terminal stretch hydrophobic), equivalent to Q9CCM7|ML0643 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (340 aa), FASTA scores: opt: 1822, E(): 1.6e-102, (80.3% identity in 340 aa overlap). Also similar to other proteins e.g. Q9FCI6|2SC3B6.26 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (364 aa), FASTA scores: opt: 430, E(): 1.1e-18, (40.95% identity in 359 aa overlap); Q9S3Y5|SDRC SDRC PROTEIN from Streptomyces coelicolor (241 aa), FASTA scores: opt: 396, E(): 8.9e-17, (35.2% identity in 318 aa overlap) (similarity in part for this one); O34470|YLBL YLBL PROTEIN from Bacillus subtilis (350 aa), FASTA scores: opt: 385, E(): 5.6e-16, (27.7% identity in 350 aa overlap); etc. TBparse score is 0.890." /codon_start=1 /transl_table=11 /product="POSSIBLE CONSERVED SECRETED PROTEIN" /protein_id="CAA16659.1" /db_xref="GI:2827604" /db_xref="GOA:O53340" /db_xref="InterPro:IPR001478" /db_xref="UniProtKB/TrEMBL:O53340" /translation="MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEI DGKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGK SREEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAV DGTPVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVV DAPWAPFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQ IGGITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSG SPTPSC" gene 96701..98119 /locus_tag="Rv3195" CDS 96701..98119 /locus_tag="Rv3195" /function="UNKNOWN" /note="Rv3195, (MTV014.39), len: 472 aa. Hypothetical protein, equivalent to Q49746|ML0642|B1937_C3_231 HYPOTHETICAL 50.3 KDA PROTEIN from Mycobacterium leprae (479 aa), FASTA scores: opt: 2503, E(): 1e-138, (79.35% identity in 475 aa overlap). Similar in part to Q9FCI9|2SC3B6.23c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (487 aa), FASTA scores: opt: 1382, E(): 2.7e-73, (46.4% identity in 489 aa overlap); Q9X8I7|SCE9.14 HYPOTHETICAL 41.2 KDA PROTEIN from Streptomyces coelicolor (375 aa), FASTA scores: opt: 319, E(): 2.4e-11, (25.6% identity in 383 aa overlap); etc. TBparse score is 0.893." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16660.1" /db_xref="GI:2827605" /db_xref="UniProtKB/TrEMBL:O53341" /translation="MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPL GAFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIA PIPAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMA QQISTVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLP LGPKGVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVE AYAMGMKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETL LALIEGWVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLR EAGALWERLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAE LERDQQARGADDSGHDGGPVDN" gene 98125..99024 /locus_tag="Rv3196" CDS 98125..99024 /locus_tag="Rv3196" /function="UNKNOWN" /note="Rv3196, (MTV014.40), len: 299 aa. Hypothetical protein, with some similarity to other hypothetical proteins e.g. Q9FCJ5|2SC3B6.17c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (442 aa), FASTA scores: opt: 233, E(): 3.5e-07, (29.9% identity in 261 aa overlap). TBparse score is 0.936." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA16661.1" /db_xref="GI:2827606" /db_xref="UniProtKB/TrEMBL:O53342" /translation="MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRR AVLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGV ATPLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVD LVVLSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSD RDAAWPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTT LEFDLNAGSIVARQWTRHPRCFC" gene complement(99033..99233) /locus_tag="Rv3196A" CDS complement(99033..99233) /locus_tag="Rv3196A" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3196A, len: 66 aa. Hypothetical unknown protein." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAE55563.1" /db_xref="GI:38490334" /db_xref="UniProtKB/TrEMBL:Q8VJ55" /translation="MQEGGPQETMSARSTQHDAADALFRAIIETLDKHRNERTLTEDV LDTLARAYASISTNVPEQGRLG" gene 99361..100704 /locus_tag="Rv3197" CDS 99361..100704 /locus_tag="Rv3197" /function="THOUGHT TO BE INVOLVED IN ACTIVE TRANSPORT ACROSS THE MEMBRANE. RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM." /note="Rv3197, (MTV014.41), len: 447 aa. Probable conserved ATP-binding protein ABC transporter, highly similar to Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140, (83.0% identity in 447 aa overlap). Interestingly, the N-terminal half (1-219 aa) corresponds to Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68, (88.6% identity in 219 aa overlap); and the C-terminal half (239-447 aa) corresponds to Q49745|B1937_C2_179 HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt: 1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap); two adjacent orfs from Mycobacterium leprae. Also highly similar to other proteins (generally ABC transporters) e.g. Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340, E(): 1.8e-71, (45.9% identity in 449 aa overlap); O65576|ABC1AT ABC1 PROTEIN (alias Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa overlap); O27682|MTH1645 ABC TRANSPORTER from Methanobacterium thermoautotrophicum (623 aa), FASTA scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). TBparse score is 0.892." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER" /protein_id="CAA16662.1" /db_xref="GI:2827607" /db_xref="GOA:O53343" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR004147" /db_xref="UniProtKB/TrEMBL:O53343" /translation="MDDGSVSDIKRGRAARNAKLASIPVGFAGRAALGLGKRLTGKSK DEVTAELMEKAANQLFTVLGELKGGAMKVGQALSVMEAAIPDEFGEPYREALTKLQKD APPLPASKVHRVLDGQLGTKWRERFSSFNDTPVASASIGQVHKAIWSDGREVAVKIQY PGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEMELDYRLEAANQRAFA KAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDA PRRLGLMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGGFPIELGMTIRLAREKNYDLL LPTMEKAGLIQRGRQVSVREIDEMLRQYVEPIQVEVFHYTRKWLQKMTVSQIDRSVAQ IRTARQMDLPAKLAIPMRVIASVGAILCQLDAHVPIKALSEELIPGFAEPDAIVV" misc_feature 99466..99489 /locus_tag="Rv3197" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene complement(100738..101016) /gene="whiB7" /locus_tag="Rv3197A" CDS complement(100738..101016) /gene="whiB7" /locus_tag="Rv3197A" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /standard_name="whmC" /note="Rv3197A, len: 92 aa. Probable whiB7 (alternate gene name: whmC), WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q49765|WHIB7|ML0639|B1937_F2_68 PUTATIVE TRANSCRIPTIONAL REGULATOR WHIB7 from Mycobacterium leprae (89 aa), FASTA scores: opt: 441, E(): 6.3e-24, (69.3% identity in 88 aa overlap). Similar to Q9FCJ8|2SC3B6.14 PUTATIVE DNA-BINDING PROTEIN from Streptomyces coelicolor (122 aa), FASTA scores: opt: 348, E(): 2.2e-17, (57.7% identity in 78 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa), FASTA scores: opt: 166, E(): 7.1e-05, (39.4% identity in 76 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB7" /protein_id="CAE55564.1" /db_xref="GI:38490335" /db_xref="GOA:Q6MX01" /db_xref="InterPro:IPR000637" /db_xref="InterPro:IPR003482" /db_xref="UniProtKB/TrEMBL:Q6MX01" /translation="MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCV SCPIRRQCLAAALQRAEPWGVWGGEIFDQGSIVSHKRPRGRPRKDAVA" gene complement(101446..103548) /gene="uvrD2" /locus_tag="Rv3198c" CDS complement(101446..103548) /gene="uvrD2" /locus_tag="Rv3198c" /EC_number="3.6.1.-" /function="INVOLVED IN NUCLEOTIDE EXCISION REPAIR. HAS BOTH ATPASE AND HELICASE ACTIVITIES. UNWINDS DNA DUPLEXES WITH 3' TO 5' POLARITY WITH RESPECT TO THE BOUND STRAND AND INITIATES UNWINDING MOST EFFECTIVELY WHEN A SINGLE-STRANDED REGION IS PRESENT. INVOLVED IN THE POSTINCISION EVENTS OF NUCLEOTIDE EXCISION REPAIR AND METHYL-DIRECTED MISMATCH REPAIR." /note="Rv3198c, (MTV014.42c), len: 700 aa. Probable UvrD2, ATP dependent DNA helicase II (EC 3.6.1.-) (see citation below), equivalent to P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 PROBABLE DNA HELICASE II HOMOLOG from Mycobacterium leprae (714 aa), FASTA scores: opt: 3749, E(): 0, (82.85% identity in 706 aa overlap); and C-terminal half (466-700 aa) corresponds to Q49764|RECQ|B1937_F2_66 PUTATIVE DNA HELICASE RECQ (EC 3.6.1.-) (242 aa), FASTA scores: opt: 1267, E(): 1.4e-69, (82.5% identity in 234 aa overlap); products of two adjacent ORFS in Mycobacterium leprae. Also similar to other DNA helicases e.g. Q9FCK0|2SC3B6.12 from Streptomyces coelicolor (785 aa), FASTA scores: opt: 1687, E(): 1.2e-94, (52.05% identity in 728 aa overlap); P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in 710 aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153 ATP-DEPENDENT DNA HELICASE PCRA from Mycobacterium leprae (778 aa), FASTA scores: opt: 687, E(): 5.1e-34, (32.0% identity in 719 aa overlap); O83991|TP1028 DNA HELICASE II (UVRD) from Treponema pallidum (670 aa), FASTA scores: opt: 652, E(): 6e-32, (30.25% identity in 671 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE UVRD SUBFAMILY OF HELICASES. TBparse score is 0.903." /codon_start=1 /transl_table=11 /product="PROBABLE ATP-DEPENDENT DNA HELICASE II UVRD2" /protein_id="CAA16663.1" /db_xref="GI:2827608" /db_xref="GOA:P64320" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR002121" /db_xref="UniProtKB/Swiss-Prot:P64320" /translation="MSIASDPLIAGLDDQQREAVLAPRGPVCVLAGAGTGKTRTITHR IASLVASGHVAAGQVLAVTFTQRAAGEMRSRLRALDAAARTGSGVGAVQALTFHAAAY RQLRYFWSRVIADTGWQLLDSKFAVVARAASRTRLHASTDDVRDLAGEIEWAKASLIG PEEYVTAVAAARRDPPLDAAQIAAVYSEYEALKARGDGVTLLDFDDLLLHTAAAIEND AAVAEEFQDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGASP RFLLDFSRRFPDAAVVRLERDYRSTPQVVSLANRVIAAARGRVAGSKLRLSGQREPGP VPSFHEHSDEPAEAATVAASIARLIASGTPPSEVAILYRVNAQSEVYEEALTQAGIAY QVRGGEGFFNRQEIKQALLALQRVSERDTDAALSDVVRAVLAPLGLTAQPPVGTRARE RWEALTALAELVDDELAQRPALQLPGLLAELRRRAEARHPPVVQGVTLASLHAAKGLE WDAVFLVGLADGTLPISHALAHGPNSEPVEEERRLLYVGITRARVHLALSWALSRSPG GRQSRKPSRFLNGIAPQTRADPVPGTSRRNRGAAARCRICNNELNTSAAVMLRRCETC AADVDEELLLQLKSWRLSTAKEQNVPAYVVFTDNTLIAIAELLPTDDAALIAIPGIGA RKLEQYGSDVLQLVRGRT" misc_feature complement(103435..103458) /gene="uvrD2" /locus_tag="Rv3198c" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene 103672..103926 /locus_tag="Rv3198A" CDS 103672..103926 /locus_tag="Rv3198A" /EC_number="1.-.-.-" /function="UNKNOWN" /note="Rv3198A, len: 84 aa. Possible glutaredoxin protein (EC 1.-.-.-), highly similar to Q9FCK1|2SC3B6.11c PUTATIVE GLUTAREDOXIN-LIKE PROTEIN from Streptomyces coelicolor (80 aa), FASTA scores: opt: 293, E(): 2.2e-14, (55.15% identity in 78 aa overlap); and Q9RSN9|DR2085 PUTATIVE GLUTAREDOXIN from Deinococcus radiodurans (81 aa), FASTA scores: opt: 198, E(): 1.2e-07, (53.55% identity in 56 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9X8C2|SCE36.09 HYPOTHETICAL 13.0 KDA PROTEIN from Streptomyces coelicolor (114 aa), FASTA scores: opt: 181, E(): 2.6e-06, (44.45% identity in 72 aa overlap)." /codon_start=1 /transl_table=11 /product="POSSIBLE GLUTAREDOXIN PROTEIN" /protein_id="CAE55565.1" /db_xref="GI:38490336" /db_xref="GOA:Q8VJ51" /db_xref="InterPro:IPR006662" /db_xref="InterPro:IPR011915" /db_xref="UniProtKB/TrEMBL:Q8VJ51" /translation="MITAALTIYTTSWCGYCLRLKTALTANRIAYDEVDIEHNRAAAE FVGSVNGGNRTVPTVKFADGSTLTNPSADEVKAKLVKIAG" gene complement(103939..104880) /gene="nudC" /locus_tag="Rv3199c" CDS complement(103939..104880) /gene="nudC" /locus_tag="Rv3199c" /EC_number="3.6.1.22" /function="INVOLVED IN NICOTINATE AND NICOTINAMIDE METABOLISM. GENERATES AMP AND NMN FROM NAD(+) AND H(2)O. ACTING ON ACID ANHYDRIDES, IN PHOSPHORUS-CONTAINING ANHYDRIDES. ALSO ACTS ON NADP+, 3-ACETYLPYRIDINE AND THE THIONICOTINAMIDE ANALOGUES OF NAD+ AND NADP+ [CATALYTIC ACTIVITY: NADH + H(2)O = AMP + NMNH]." /note="Rv3199c, (MTV014.43)c, len: 313 aa. Probable nudC, NADH pyrophosphatase (EC 3.6.1.22), similar in particular to Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa), FASTA scores: opt: 493, E(): 7.4e-24, (39.65% identity in 232 aa overlap); Q9ABG1|CC0266 MUTT/NUDIX FAMILY PROTEIN from Caulobacter crescentus (313 aa), FASTA scores: opt: 479, E(): 5.1e-23, (38.3% identity in 222 aa overlap); O86062|NUDC_PSEAE|NUDC|PA1823 NADH PYROPHOSPHATASE from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 371,2 E(): 3e-16, (43.15% identity in 153 aa overlap); Q9RV62|NUDC_DEIRA|NUDC|DR1168 NADH PYROPHOSPHATASE from Deinococcus radiodurans (280 aa), FASTA scores: opt: 363, E(): 9.6e-16, (34.45% identity in 270 aa overlap); etc. Caution: equivalent to AAK47636 from Mycobacterium tuberculosis strain CDC1551 (386 aa) but shorter 72 aa. Contains PS00893 mutT domain signature. BELONGS TO THE NUDIX HYDROLASE FAMILY, NUDC SUBFAMILY. COFACTOR: REQUIRES DIVALENT IONS: MANGANESE OR MAGNESIUM. TBparse score is 0.906." /codon_start=1 /transl_table=11 /product="PROBABLE NADH PYROPHOSPHATASE NUDC (NAD+ DIPHOSPHATASE) (NAD+ PYROPHOSPHATASE) (NADP PYROPHOSPHATASE)" /protein_id="CAA16664.1" /db_xref="GI:2827609" /db_xref="GOA:O53345" /db_xref="InterPro:IPR000086" /db_xref="UniProtKB/Swiss-Prot:O53345" /translation="MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAAL LRVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPD IPAEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNP ITGHEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVARE IREEIGLTVRDVRYLGSQQWPFPRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEV RAALAAGDWSSASESKLLLPGSISIARVIIESWAACE" misc_feature complement(104215..104274) /gene="nudC" /locus_tag="Rv3199c" /note="PS00893 mutT domain signature" gene complement(104939..106006) /locus_tag="Rv3200c" CDS complement(104939..106006) /locus_tag="Rv3200c" /function="THOUGHT TO BE INVOLVED IN CATION TRANSPORT ACROSS THE MEMBRANE." /note="Rv3200c, (MTV014.44c), len: 355 aa. Possible transmembrane cation transporter, similar to many transmembrane proteins and putative potassium channels e.g. Q9XA52|SCGD3.27C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (365 aa), FASTA scores: opt: 1022, E(): 2.6e-53, (49.85% identity in 325 aa overlap); Q9RRZ3|DR2336 PUTATIVE POTASSIUM CHANNEL from Deinococcus radiodurans (320 aa), FASTA scores: opt: 436, E(): 1e-18, (30.9% identity in 304 aa overlap); O28600|AF1673 PUTATIVE POTASSIUM CHANNEL from Archaeoglobus fulgidus (314 aa), FASTA scores: opt: 363, E(): 2.1e-14, (27.2% identity in 309 aa overlap); Q57604|Y13B_METJAMJ0138.1|MJ0138.1 PUTATIVE POTASSIUM CHANNEL from Methanococcus jannaschii (333 aa), FASTA scores: opt: 356, E(): 5.7e-14, (26.0% identity in 281 aa overlap); P73132|SLL0993 POTASSIUM CHANNEL from Synechocystis sp. strain PCC 6803 (365 aa), FASTA scores: opt: 330, E(): 2.1e-12, (27.8% identity in 324 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.904." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSMEMBRANE CATION TRANSPORTER" /protein_id="CAA16665.1" /db_xref="GI:2827610" /db_xref="GOA:O53346" /db_xref="InterPro:IPR001622" /db_xref="InterPro:IPR003148" /db_xref="UniProtKB/TrEMBL:O53346" /translation="MAGSWRRLRGLNEKLTAQPGYALVGVLRIPQRRASPARVISRRV VVAVVALLLTAGIVYVDRDGYLDAQGDRLTFLDCLYYAAVTLSTTGYGDITPISEFAR AINIFVITPLRIAFLILLVGTTLEVLTETSRQAYKIQRWRSRVRNHTVVIGYGTKGKT AVAAMVSDELVPGEIVVVDTDSGVLERAAAAGLVTVHGDATKSDVLRLAGTQHASSII VATSRDDTAVLVTLTAREIAPKAKIVASIREAENQHLLRQSGADTVVVSSETAGRLLG IATTTPSVVEMIEDLLTPEAGLAVAEREVEQAEVGGSPRHLRDIVLGVVRDGQLLRIG APEVDAIEASDRLLYIRQVGR" misc_feature complement(105527..105550) /locus_tag="Rv3200c" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene complement(106068..109373) /locus_tag="Rv3201c" CDS complement(106068..109373) /locus_tag="Rv3201c" /EC_number="3.6.1.-" /function="HAS BOTH ATPASE AND HELICASE ACTIVITIES" /note="Rv3201c, (MTV014.45c), len: 1101 aa. Probable ATP-dependent DNA helicase (EC 3.6.1.-), similar to others e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 aa), FASTA scores: opt: 1209, E(): 5.4e-63, (38.45% identity in 1199 aa overlap); P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 403, E(): 6.5e-16, (28.15% identity in 717 aa overlap); Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity in 1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp. (512 aa; fragment), FASTA scores: opt: 290, E(): 2e-09, (27.95% identity in 479 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). TBparse score is 0.909." /codon_start=1 /transl_table=11 /product="PROBABLE ATP-DEPENDENT DNA HELICASE" /protein_id="CAA16666.1" /db_xref="GI:2827611" /db_xref="GOA:O53347" /db_xref="InterPro:IPR000212" /db_xref="UniProtKB/TrEMBL:O53347" /translation="MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAG AGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGIGLGC GDPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDTRLLSETELWQLAFDVVSGYDGVLC TDKSPAAVTSIVVRLWGQLGEHLVDTRALRDTHVELERLVHALPAGRYQRDRGPSQWL LRMLATQTQRAELVPLLDALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYR VVLLDEYQDTGHAQRVVLSSLFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTT DFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRALRPRPDAPPGAVR CALLPDVQAEREWIADHLRMRYQRAEADGVKPPTAAVLVRRNADAAAIADTLRARGIP AEVVGLAGLLSIPEVAEVVAMLRLVADPTAGAAAMRVLTGPRWRLGARDLAALWRRAL TLSGESPSTASPESIAMAASADADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSA LRGRLGHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAERASA RSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVHAAKGLEWQVVAVAHLS RGVFPSTVSRSSWLTDPAELPPLLRGDRASAGAHGIPVLDTSAVADRKQLSDKISEHR RLLDRRRVDEERRLLYVAVTRAEDTLLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSA AAGDPCGVVEQWASAPAGDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSA DLPGSTTDIDHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGD PVGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADREVGDPEE LAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAVFVDPDGGATVVDWKTGK PPHGPAAMRQAAVQLAVYRLAWAALRGCPTSSVRTAFYYVRSGITVVPDELPAPGELA MLLTDCAGRRSDT" misc_feature complement(109224..109247) /locus_tag="Rv3201c" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene complement(109370..112537) /locus_tag="Rv3202c" CDS complement(109370..112537) /locus_tag="Rv3202c" /EC_number="3.6.1.-" /function="HAS BOTH ATPASE AND HELICASE ACTIVITIES" /note="Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa. Possible ATP-dependent DNA helicase (EC 3.6.1.-), showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 PUTATIVE ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 MISMATCH REPAIR PROTEIN MUTU (DNA HELICASE II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06, (23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar to Q9FDU2|ORF3 ORF3 PROTEIN (FRAGMENT) from Streptomyces griseus (551 aa), FASTA scores: opt: 800, E(): 1.7e-37, (36.2% identity in 525 aa overlap); and Q9ZG15 HYPOTHETICAL 35.5 KDA PROTEIN from Rhodococcus erythropolis (323 aa), FASTA scores: opt: 232, E(): 9.7e-06, (28.55% identity in 266 aa overlap)." /codon_start=1 /transl_table=11 /product="POSSIBLE ATP-DEPENDENT DNA HELICASE" /protein_id="CAA16669.1" /db_xref="GI:3242281" /db_xref="GOA:O53348" /db_xref="InterPro:IPR000212" /db_xref="UniProtKB/TrEMBL:O53348" /translation="MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLVEAAVAHIG AGTDPESVLLLTGSGRMGMRARSALTTALLRSRTNGPCRAAIREPVVRTVHSYAYAVL RKAAQRAGDALPRLLTSAEQDAIIRELLAGDAEDGPAATTTWPAHLRPALTTAGFATE LRNLLARCAERGLDPLELQQLGRRRGRPEWIAAGQFAQRYEQVMLLRGAVGLAAPQAT APALSAAELVGAALEAFAVDPELLAAERARVRTLLVDDAQQLDPQAARLVRMLAAGTE LALIAGDPNQAVFGFRGGEPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGI ARRLPGRSVGRRIEGTGTEVGSVTVRLAGSAHAEAAMIADALRRAHLIDGVPWSQMAV IVRSVPRAVRLPRALAAAGVPVAPPAVGGPLSAEPAVRALLTVLEATADGLDGDQALL LLTGPIGGVDPVSLRQLRRTLQRARPGQTSRKFGDLLVEVLGGDAPPSGPGSRALRRV RAVLTAAARCHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAAVQATRDLET VTALFDITDHYVSRTSGASLRGLVEHVTALQLPVVRPEPAAPTEQVMVLSAHAALGHE WDLVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTKDASMRAPLLAEERRLLVTAM GRARRRLLVTAVDSDAGGGGHEAVLPSAFFFEIAQWADGDGEPVAMQPVSAPRVLSAA AVVGRLRVVVCAPACAVDDADRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLC DSDDLVTLTPSTLQALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRSESQL LAELDRVWGHLPFGAQWYSANELARHRAMIQAFVQWRAQSRSELTEVGVEVDIDGALE DGSGQARKIRLRGRADRLERDPAGRLVIVDIKTGKTPVSKDDAQQHAQLAMYQLAVAE GLVRAGDEPGGARLVYVGKSGAAGVAERKQDPLTPAARDEWRNLVRQLAAATAGPQFI ARRNDGCTHCPLRPGCPAHVRGSAP" gene 112975..113649 /gene="lipV" /locus_tag="Rv3203" CDS 112975..113649 /gene="lipV" /locus_tag="Rv3203" /EC_number="3.1.-.-" /function="UNKNOWN; PRESUMED LIPOLYTIC ENZYME INVOLVED IN CELLULAR METABOLISM." /note="Rv3203, (MTCY07D11.23c), len: 224 aa. Possible lipV, hydrolase lipase (EC 3.1.-.-), showing some similarity to other lipases e.g. Q9JSN0|NMA2216 PUTATIVE HYDROLASE from Neisseria meningitidis (serogroup A) (312 aa), FASTA scores: opt: 192, E(): 0.00016, (45.2% identity in 73 aa overlap); Q9RK95|SCF1.09 PUTATIVE HYDROLASE from Streptomyces coelicolor (258 aa), FASTA scores: opt: 188, E(): 0.00024, (30.1% identity in 226 aa overlap); Q9KZC3|SC6F7.19c PUTATIVE LIPASE from Streptomyces coelicolor (269 aa), FASTA scores: opt: 179, E(): 0.00086, (36.35% identity in 121 aa overlap); etc. Equivalent to AAK47641 Hydrolase, alpha/beta hydrolase family from Mycobacterium tuberculosis strain CDC1551 (261 aa) but shorter 37 aa. Contains serine active site signature of lipases (PS00120)." /codon_start=1 /transl_table=11 /product="POSSIBLE LIPASE LIPV" /protein_id="CAB08320.1" /db_xref="GI:3261740" /db_xref="GOA:O05863" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000379" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR003089" /db_xref="InterPro:IPR008262" /db_xref="UniProtKB/TrEMBL:O05863" /translation="MPEIPIAAPDLLGHGRSPWAAPWTIDANVSALAALLDNQGDGPV VVVGHSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDAMLASPDYLDPAE ARAEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRISLPAMVCYWSELARDIVLPP VGTATTLVRAVRASPAYVSDQLLAALDKRLGADFELLDFDCGHMVPQAKPTEVAAVIR SRLGPR" misc_feature 113104..113133 /gene="lipV" /locus_tag="Rv3203" /note="PS00120 Lipases, serine active site" gene 113652..113957 /locus_tag="Rv3204" CDS 113652..113957 /locus_tag="Rv3204" /EC_number="2.1.1.-" /function="CAUSES METHYLATION." /note="Rv3204, (MTCY07D11.22c), len: 101 aa. Possible DNA methyltransferase (EC 2.1.1.-), similar to many hypothetical bacteriel proteins and methyltransferases e.g. Q9KT40|VC1065 METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE-RELATED PROTEIN from Vibrio cholerae (100 aa), FASTA scores: opt: 170, E(): 2.8e-05, (34.35% identity in 99 aa overlap); Q9UTN9|SPAC1250.04c PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (108 aa), FASTA scores: opt: 161, E(): 0.00013, (36.65% identity in 101 aa overlap); Q9YDF4|APE0959 175 AA LONG HYPOTHETICAL METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE from Aeropyrum pernix (175 aa), FASTA scores: opt: 144, E(): 0.003, (37.95% identity in 87 aa overlap); Q50855 PUTATIVE METHYLGUANINE-DNA METHYLTRANSFERASE from Myxococcus xanthus (147 aa), FASTA scores: opt: 141, E(): 0.0041, (37.65% identity in 93 aa overlap); etc." /codon_start=1 /transl_table=11 /product="POSSIBLE DNA-METHYLTRANSFERASE (MODIFICATION METHYLASE)" /protein_id="CAB08312.1" /db_xref="GI:2072681" /db_xref="GOA:O05862" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR011991" /db_xref="UniProtKB/TrEMBL:O05862" /translation="MAPVTDEQVELVRSLVAAIPLGRVSTYGDIAALTGLSSPRIVGW IMRTDSSDLPWHRVIRASGRPAQHLATRQLELLRAEGVLSVDGRVALSEIRYEFPPG" gene complement(113964..114842) /locus_tag="Rv3205c" CDS complement(113964..114842) /locus_tag="Rv3205c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3205c, (MTCY07D11.21), len: 292 aa. Hypothetical protein, highly similar to Q9CCG7|ML0818 HYPOTHETICAL PROTEIN from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08311.1" /db_xref="GI:2072680" /db_xref="UniProtKB/TrEMBL:O05861" /translation="MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGE VVLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPR HDEVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGV PTAPPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYW RPASWAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAE AFPGLAHTAALVRLVL" gene complement(114869..116047) /gene="moeB1" /locus_tag="Rv3206c" CDS complement(114869..116047) /gene="moeB1" /locus_tag="Rv3206c" /function="POSSIBLY INVOLVED IN MOLYBDOPTERIN METABOLISM (SYNTHESIS)" /standard_name="moeZ" /experiment="experimental evidence, no additional details recorded" /note="Rv3206c, (MTCY07D11.20), len: 392 aa. Probable moeB1, molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 2285, E(): 3.3e-130, (86.45% identity in 391 aa overlap.) Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1776, E(): 1.4e-99, (65.3% identity in 395 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1526, E(): 1.5e-84, (59.1% identity in 391 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1309, E(): 1.8e-71, (52.95% identity in 387 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1308, E(): 2e-71, (50.65% identity in 397 aa overlap); etc. Also highly similar to O05792|MOEB2|Rv3116|MTCY164.26 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (389 aa), FASTA scores: opt: 1440, E(): 2.3e-79, (57.25% identity in 386 aa overlap). Has hydrophobic segment from ~45-71. BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeZ. Thought to be differentially expressed within host cells (see citation below)." /codon_start=1 /transl_table=11 /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE)" /protein_id="CAE55566.1" /db_xref="GI:38490337" /db_xref="GOA:Q7D5X9" /db_xref="InterPro:IPR000205" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR007901" /db_xref="UniProtKB/TrEMBL:Q7D5X9" /translation="MSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNAR VLVIGAGGLGAPTLLYLAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSAR DSIVAINPLIRVRLHELRLAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPY VWGSIYRFEGQASVFWEDAPDGLGVNYRDLYPEPPPPGMVPSCAEGGVLGIICASVAS VMGTEAIKLITGIGETLLGRLLVYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVV ADDAAQAAKGSTITPRELRDWLDSGRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSG EGLAKLPQDRTAVLYCKTGVRSAEALAAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY " gene complement(116138..116995) /locus_tag="Rv3207c" CDS complement(116138..116995) /locus_tag="Rv3207c" /function="UNKNOWN" /note="Rv3207c, (MTCY07D11.19), len: 285 aa. Hypothetical protein, highly similar but shorter (57 aa) to Q9CCG9|ML0816 HYPOTHETICAL PROTEIN from Mycobacterium leprae (341 aa), FASTA scores: opt: 1676, E(): 9.7e-96, (81.0% identity in 284 aa overlap). Also similar to C-terminus of Q9FBI6|SCP8.36 HYPOTHETICAL PROTEIN from Streptomyces coelicolor (559 aa), FASTA scores: opt: 426, E(): 8.4e-19, (37.35% identity in 281 aa overlap); and similar to other hypothetical proteins (generally membrane proteins) e.g. Q9K456|SC2H12.28C PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor (314 aa), FASTA scores: opt: 341, E(): 8.8e-14, (29.75% identity in 296 aa overlap). Contains neutral zinc metallopeptidases, zinc-binding region signature (PS00142)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08309.1" /db_xref="GI:2072678" /db_xref="GOA:O05859" /db_xref="InterPro:IPR006025" /db_xref="InterPro:IPR006026" /db_xref="UniProtKB/TrEMBL:O05859" /translation="MSTYGWRAYALPVLMVLTTVVVYQTVTGTSTPRPAAAQTVRDSP AIGVVGTAILDAPPRGLAVFDANLPAGTLPDGGPFTEAGDKTWRVVPGTTPQVGQGTV KVFRYTVEIENGLDPTMYGGDNAFAQMVDQTLTNPKGWTHNPQFAFVRIDSGKPDFRI SLVSPTTVRGGCGYEFRLETSCYNPSFGGMDRQSRVFINEARWVRGAVPFEGDVGSYR QYVINHEVGHAIGYLRHEPCDQQGGLAPVMMQQTFSTSNDDAAKFDPDFVKADGKTCR FNPWPYPIP" misc_feature complement(116306..116335) /locus_tag="Rv3207c" /note="PS00142 Neutral zinc metallopeptidases, zinc-binding region signature" gene 117341..118027 /locus_tag="Rv3208" CDS 117341..118027 /locus_tag="Rv3208" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3208, (MTCY07D11.18c), len: 228 aa. Probable transcriptional regulator, tetR family, equivalent to Q9CCH0|ML0815 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (228 aa), FASTA scores: opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa overlap). Also highly similar to Q9FBI8|SCP8.33c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (213 aa), FASTA scores: opt: 629, E(): 4e-34, (45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R (FRAGMENT) from Streptomyces coelicolor A3(2) (149 aa), FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity in 147 aa overlap); Q9K3T5|SCE66.08 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (225 aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15% identity in 212 aa overlap); Q9RYK4|DRA0308 TRANSCRIPTIONAL REGULATOR, TETR FAMILY from Deinococcus radiodurans (239 aa), FASTA scores: opt: 290, E(): 6.5e-12, (30.5% identity in 223 aa overlap); etc. And also similar to Mycobacterium tuberculosis proteins P96381|Rv1019|MTCY10G2.30c HYPOTHETICAL 21.7 KDA PROTEIN (197 aa), FASTA scores: opt: 356, E(): 2.7e-16, (34.4% identity in 189 aa overlap); MTV034_4; MTY07A7A_3; MTV032_1; MTCY07A7_12; etc. Contains probable helix-turn-helix motif at aa 60-81 (Score 1517, +4.35 SD). SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)" /protein_id="CAB08308.1" /db_xref="GI:2072677" /db_xref="GOA:O05858" /db_xref="InterPro:IPR001647" /db_xref="UniProtKB/TrEMBL:O05858" /translation="MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQL LVVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGV HQALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCI DAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWG GLSHVPLTRS" gene complement(118014..118286) /gene="TB9.4" /locus_tag="Rv3208A" CDS complement(118014..118286) /gene="TB9.4" /locus_tag="Rv3208A" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3208A, len: 90 aa. TB9.4, conserved hypothetical protein (see citations below), equivalent to Q9CCH1|ML0814 HYPOTHETICAL PROTEIN from Mycobacterium leprae (82 aa), FASTA scores: opt: 411, E(): 1.8e-22, (81.0% identity in 79 aa overlap). Also similar, but shorter in N-terminus, to Q9FBI9|SCP8.32c PUTATIVE ATP-BINDING PROTEIN from Streptomyces coelicolor (94 aa), FASTA scores: opt: 246, E(): 8.1e-11, (53.4% identity in 73 aa overlap); Q9DGP6 (alias Q9DGP4) GLUTAMATE DECARBOXYLASE 67 KDA ISOFORM (FRAGMENT) from Alepocephalus bairdii (182 aa), FASTA scores: opt: 100, E(): 2.6, (35.3% identity in 85 aa overlap). Corresponds to Statens Serum Institute antigen, CYP10 TB9.4. Has N-terminal sequence, VEVKIGITDSPRELV." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN TB9.4" /protein_id="CAE55567.1" /db_xref="GI:38490338" /db_xref="UniProtKB/TrEMBL:Q6MWZ8" /translation="MEVKIGITDSPRELVFSSAQTPSEVEELVSNALRDDSGLLTLTD ERGRRFLIHTARIAYVEIGVADARRVGFGVGVDAAAGSAGKVATSG" gene 118611..119171 /locus_tag="Rv3209" CDS 118611..119171 /locus_tag="Rv3209" /function="UNKNOWN" /note="Rv3209, (MTCY07D11.17c), len: 186 aa. Conserved hypothetical thr-, pro-rich protein, equivalent (but shorter 36 aa in N-terminus) to Q9CCH2|ML0813 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (195 aa), FASTA scores: opt: 508, E(): 1.4e-15, (58.4% identity in 185 aa overlap). Also some similarity with Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from M. tuberculosis (299 aa), FASTA scores: opt: 339, E(): 3.7e-08, (35.0% identity in 180 aa overlap); and Q9CCE9|MMPS3|ML0877 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (293 aa), FASTA scores: opt: 272, E(): 2.8e-05, (36.4% identity in 173 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL THREONIN AND PROLINE RICH PROTEIN" /protein_id="CAB08307.1" /db_xref="GI:2072676" /db_xref="UniProtKB/TrEMBL:O05857" /translation="MALGAVATAVIINSGDSTSTKAIVGAPAPRTVISTSPRPTAPTS TSPHPSPSTLRPQLPPETVTTVAPPGTGPTTVPTRTPTAAPPQTAVPPPAPLNPRTVV YRVTGTKQLFDLVNVVYTDARGFPVTDFNVSLPWTKMVVLNPGVQTESVVATSLYSRL NCSIVNTGAQTVVASTNNAIIATCTR" gene complement(119181..119876) /locus_tag="Rv3210c" CDS complement(119181..119876) /locus_tag="Rv3210c" /function="UNKNOWN" /note="Rv3210c, (MTCY07D11.16), len: 231 aa. Conserved hypothetical protein, similar (but N-terminus shorter) to Q9FBJ1|SCP8.30 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (260 aa), FASTA scores: opt: 599, E(): 1.1e-30, (42.5% identity in 233 aa overlap); and some similarity to Q9RRV1|DR2384 PHENYLACETIC ACID DEGRADATION PROTEIN PAAC from Deinococcus radiodurans (263 aa), FASTA scores: opt: 129, E(): 0.43, (27.9% identity in 172 aa overlap); and Q9F621 FLGK PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (472 aa)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08306.1" /db_xref="GI:2072675" /db_xref="GOA:O05856" /db_xref="InterPro:IPR002197" /db_xref="UniProtKB/TrEMBL:O05856" /translation="MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLT DEARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLT TPSTWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAA VTASGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQ QTHDQRMRELGLS" gene 120135..121718 /gene="rhlE" /locus_tag="Rv3211" CDS 120135..121718 /gene="rhlE" /locus_tag="Rv3211" /function="HAS A HELIX-DESTABILIZING ACTIVITY" /note="Rv3211, (MTCY07D11.15c), len: 527 aa. Probable rhlE, ATP-dependent RNA helicase, equivalent (but shorter 22 aa) to Q9CCH3|RHLE|ML0811 PUTATIVE ATP-DEPENDENT RNA HELICASE from Mycobacterium leprae (544 aa), FASTA scores: opt: 2497, E(): 8.7e-131, (74.75% identity in 531 aa overlap). Also highly similar to other RNA helicases e.g. Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879 aa), FASTA scores: opt: 1458, E(): 3.6e-73, (52.5% identity in 522 aa overlap); Q9DF36 from Xenopus laevis (African clawed frog) (800 aa), FASTA scores: opt: 792, E(): 2.3e-36, (37.15% identity in 385 aa overlap); Q99Z38|DEAD|SPY1415 from Streptococcus pyogenes (759 aa), FASTA scores: opt: 779, E(): 1.1e-35, (37.1% identity in 380 aa overlap); P33906|DEAD|CSDA from Klebsiella pneumoniae (642 aa), FASTA scores: opt: 768, E(): 4e-35, (43.4% identity in 387 aa overlap); etc. Contains ATP/GTP-binding site motif A (PS00017) and DEAD-box subfamily ATP-dependent helicases signature (PS00039). SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND SIMILAR TO HELICASE C-TERMINAL DOMAIN." /codon_start=1 /transl_table=11 /product="PROBABLE ATP-DEPENDENT RNA HELICASE RHLE" /protein_id="CAB08305.1" /db_xref="GI:2072674" /db_xref="GOA:O05855" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001410" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="UniProtKB/TrEMBL:O05855" /translation="MTAVKHTTESTFAKLGVRDEIVRALGEEGIKRPFAIQELTLPLA LDGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGAPRALVVVPTRELCLQVTD DLATAGKYLTAGPDTDDAAAVRRRLSVVSIYGGRPYEPQIEALRAGADVVVGTPGRLL DLCQQGHLQLGGLSVLVLDEADEMLDLGFLPDIERILRQIPADRQSMLFSATMPDPII TLARTFMVRPTHIRAEAPHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIF TRTKRTAQKVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGI DIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSMIDQALGLG SPDPAETYSNSPHLYAELAIPATAGGTVGPARKSQGRRRDTDCDGQKTAQHARNTPRR RRTRGGKPVTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVVSGSRSGNGEAARRR RRRRRRPTHAQDGFAARAN" misc_feature 120294..120317 /gene="rhlE" /locus_tag="Rv3211" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" misc_feature 120663..120689 /gene="rhlE" /locus_tag="Rv3211" /note="PS00039 DEAD-box subfamily ATP-dependent helicases signature" gene 121731..122954 /locus_tag="Rv3212" CDS 121731..122954 /locus_tag="Rv3212" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3212, (MTCY07D11.14c), len: 407 aa. Hypothetical ala-, val-rich protein, equivalent to Q9CCH4|ML0810 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (407 aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85% identity in 407 aa overlap). Weak similarity to several eukaryotic transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 TRANS-ACTING TRANSCRIPTIONAL PROTEIN from Herpes simplex virus (type 1 / strain 17) (775 aa), FASTA scores: opt: 115, E(): 2, (26.9% identity in 334 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL ALANINE VALINE RICH PROTEIN" /protein_id="CAB08304.1" /db_xref="GI:2072673" /db_xref="UniProtKB/TrEMBL:O05854" /translation="MVKPERRTKTDIAAAATIAVVVAVAASLIWWTSDARATISRPAA VAVPTPAPAREVPTSLKQLWTAASPATRVPVVVGGTVATGDGRQVDGRDPATGESLWS YARDTDLCGVTWVYHYAVAVYRYDRGCGQVSTIDGSTGRRGAARSGYADPRVRLFSDG TTVLSAGDTRLELWRSDMVRMLAYGEIDARVKPSNRGLQSGCTLESAAASSAAVSVLE ACTNQADLRLVLLRPGKEDDEPIQRIVPEPGVRPGSGARVLVVSQNNTAVYLPARSGA QPRVDVIDETGATVSSTLLAKPPSTSAVASRTGNLVTWWTGDALLVFDAGNLTQRYTI AAGETTAPVGPGVMMAGQLLVPVTGGIGVYDPVSGANNRYIPVTRPPSTSAVIPAVSG SRVIEQRGDTLVALG" gene complement(123029..123829) /locus_tag="Rv3213c" CDS complement(123029..123829) /locus_tag="Rv3213c" /function="UNKNOWN, BUT POSSIBLY INVOLVED IN REGULATION OF PARTITIONING." /experiment="experimental evidence, no additional details recorded" /note="Rv3213c, (MTCY07D11.13), len: 266 aa. Possible soj/parA-related protein, very similar in particular to Soj/ParA proteins (and relatives) from Bacillus subtilis that inhibit the initiation of sporulation by preventing phosphorylation of Spo0A (see Quisel & Grossman 2000) e.g. Q9S228|SCI51.12c from Streptomyces coelicolor (340 aa), FASTA scores: opt: 746, E(): 1.6e-40, (48.2% identity in 249 aa overlap); Q9HT11|SOJ|PA5563 from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 649, E(): 2.1e-34, (42.2% identity in 256 aa overlap); Q9PB62|XF2282 from Xylella fastidiosa (264 aa), FASTA scores: opt: 624, E(): 8.3e-33, (42.25% identity in 251 aa overlap); Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus halodurans (253 aa), FASTA scores: opt: 621, E(): 1.2e-32, (41.55% identity in 248 aa overlap); P37522|SOJ_BACSU (253 aa), FASTA scores: opt: 620, E(): 1.4e-32, (41.65% identity in 245; etc. Also similar to various mycobacterial proteins: U00021_10 from Mycobacterium leprae, MTCI125_29 from Mycobacterium tuberculosis, MLCB1351_6 from Mycobacterium leprae, MTV028_9c|Rv3918c|PARA PROBABLE CHROMOSOME PARTITIONING PROTEIN from Mycobacterium tuberculosis, MSGDNAB_18 from Mycobacterium leprae. SEEMS TO BELONG TO THE PARA FAMILY." /codon_start=1 /transl_table=11 /product="POSSIBLE SOJ/PARA-RELATED PROTEIN" /protein_id="CAB08303.1" /db_xref="GI:2072672" /db_xref="GOA:O05853" /db_xref="InterPro:IPR002586" /db_xref="UniProtKB/TrEMBL:O05853" /translation="MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQ GCLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMR AGREYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADKAIVPLQCEMLAHRGVG QFLRTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTV RFAEASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL" repeat_unit complement(123830..123906) /note="77 bp Mycobacterial Interspersed Repetitive Unit, Class I" gene 123983..124594 /gene="gpm2" /locus_tag="Rv3214" CDS 123983..124594 /gene="gpm2" /locus_tag="Rv3214" /EC_number="5.4.2.1" /function="INVOLVED IN GLYCOLYSIS [CATALYTIC ACTIVITY: 1,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE = 2,3-DIPHOSPHOGLYCERATE + 3-PHOSPHOGLYCERATE]." /standard_name="entD" /note="Rv3214, (MTCY07D11.12c), len: 203 aa. Possible gpm2, phosphoglycerate mutase (EC 5.4.2.1), similar to many mutases especially phosphoglycerate mutases e.g. Q9F3H5|2SCC13.14c PUTATIVE MUTASE from Streptomyces coelicolor (198 aa), FASTA scores: opt: 487, E(): 4.4e-25, (42.25% identity in 194 aa overlap); BAB49378|MLL2186 PROBABLE PHOSPHOGLYCERATE MUTASE from Rhizobium loti (Mesorhizobium loti) (193 aa), FASTA scores: opt: 423, E(): 7e-21, (41.2% identity in 182 aa overlap); Q9RKV8|SC9G1.08c PUTATIVE PHOSPHATASE from Streptomyces coelicolor (199 aa), FASTA scores: opt: 419, E(): 1.3e-20, (41.1% identity in 185 aa overlap); Q9RDL0|SCC123.14c PUTATIVE PHOSPHOGLYCERATE MUTASE from Streptomyces coelicolor (223 aa), FASTA scores: opt: 240, E(): 8.8e-09, (36.9% identity in 168 aa overlap); Q9X194|TM1374 PHOSPHOGLYCERATE MUTASE from Thermotoga maritima (201 aa), FASTA scores: opt: 218, E(): 2.3e-07, (33.15% identity in 202 aa overlap); etc. But N-terminus also similar to Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa), FASTA scores: opt: 346, E(): 2.1e-15, (55.05% identity in 109 aa overlap). N-terminus shows also some similarity with other M. tuberculosis proteins e.g. MTCY427.09c; MTCY20G9.15; MTCY428.28. Equivalent to AAK47652 from Mycobacterium tuberculosis strain CDC1551 (228 aa) but shorter 25 aa. Note that previously known as entD." /codon_start=1 /transl_table=11 /product="POSSIBLE PHOSPHOGLYCERATE MUTASE GPM2 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)" /protein_id="CAE55568.1" /db_xref="GI:38490339" /db_xref="GOA:Q6MWZ7" /db_xref="InterPro:IPR001309" /db_xref="InterPro:IPR001345" /db_xref="UniProtKB/TrEMBL:Q6MWZ7" /translation="MGVRNHRLLLLRHGETAWSTLGRHTGGTEVELTDTGRTQAELAG QLLGELELDDPIVICSPRRRTLDTAKLAGLTVNEVTGLLAEWDYGSYEGLTTPQIRES EPDWLVWTHGCPAGESVAQVNDRADSAVALALEHMSSRDVLFVSHGHFSRAVITRWVQ LPLAEGSRFAMPTASIGICGFEHGVRQLAVLGLTGHPQPIAAG" gene 124591..125709 /gene="entC" /locus_tag="Rv3215" CDS 124591..125709 /gene="entC" /locus_tag="Rv3215" /EC_number="5.4.4.2" /function="COULD BE INVOLVED IN ENTEROBACTIN BIOSYNTHESIS. ENTEROBACTIN IS AN IRON-CHELATING COMPOUND INVOLVED IN TRANSPORTING IRON FROM THE BACTERIAL ENVIRONMENT INTO THE CELL CYTOPLASM. COULD BE ALSO INVOLVED IN 2,3-DIHYDROXYBENZOATE OR ENTEROCHELIN OR MENAQUINONE BIOSYNTHESIS [CATALYTIC ACTIVITY: CHORISMATE = ISOCHORISMATE]." /note="Rv3215, (MTCY07D11.11c), len: 372 aa. Probable entC, isochorismate synthase (EC 5.4.99.6), equivalent to Q9CCH5|ENTC|ML0808 PUTATIVE ISOCHORISMATE SYNTHASE from Mycobacterium leprae (577 aa), FASTA scores: opt: 1817, E(): 5.5e-105, (73.5% identity in 366 aa overlap). Also similar to others e.g. Q9F639|MXCD PROTEIN INVOLVED IN MYXOCHELIN-TYPE IRON CHELATOR BIOSYNTHESIS (see citation below) from Stigmatella aurantiaca (408 aa), FASTA scores: opt: 893, E(): 6.2e-48, (41.6% identity in 382 aa overlap); P45744|DHBC_BACSU ISOCHORISMATE SYNTHASE from Bacillus subtilis (398 aa), FASTA scores: opt: 883, E(): 2.5e-47, (40.45% identity in 393 aa overlap); Q9KI93|CSBC ISOCHORISMATE SYNTHASE (FRAGMENT) from Azotobacter vinelandii (361 aa), FASTA scores: opt: 794, E(): 7.6e-42, (45.65% identity in 298 aa overlap); and the two Escherichia coli proteins AAG54928|ENTC (alias BAB34055|ECS0632) ISOCHORISMATE HYDROXYMUTASE 2 from Escherichia coli strain O157:H7 (391 aa), FASTA scores: opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap); P10377|ENTC|B0593 ISOCHORISMATE SYNTHASE from Escherichia coli strain K12 (391 aa), FASTA scores: opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap); etc. Stronger similarity to Escherichia coli entC. Also similar to MTCY253.35." /codon_start=1 /transl_table=11 /product="PROBABLE ISOCHORISMATE SYNTHASE ENTC (ISOCHORISMATE HYDROXYMUTASE) (ENTEROCHELIN BIOSYNTHESIS)" /protein_id="CAB08301.1" /db_xref="GI:2072670" /db_xref="GOA:O05851" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="UniProtKB/TrEMBL:O05851" /translation="MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRS GTAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTR IGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSA GNDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRH EHQLVVDTMRVALEPLCEDLTIPAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALA LHPTPAVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRR AALAHAGGGIVAESDPDDELEETTTKFATILTALGVEQ" gene 125857..126189 /locus_tag="Rv3216" CDS 125857..126189 /locus_tag="Rv3216" /EC_number="2.3.1.-" /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM." /note="Rv3216, (MTCY07D11.10c), len: 110 aa. Possible acetyltransferase (2.3.1.-), similar but shorter to many e.g. Q9AB32|CC0402 ACETYLTRANSFERASE (GNAT FAMILY) from Caulobacter crescentus (159 aa), FASTA scores: opt: 325, E(): 3.8e-17, (45.65% identity in 103 aa overlap); P79081|ATS1 PUTATIVE ACETYLTRANSFERASE ATS1 from Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa overlap); Q9I640|PA0478 PROBABLE N-ACETYLTRANSFERASE from Pseudomonas aeruginosa (158 aa), FASTA scores: opt: 308, E(): 6.9e-16, (50.0% identity in 98 aa overlap); Q9KHE3 PUTATIVE ACETYLTRANSFERASE from Anabaena sp. strain PCC 7120 (164 aa), FASTA scores: opt: 269, E(): 5.4e-13, (41.75% identity in 103 aa overlap); etc. Also some similarity to diamine acetyltransferases (EC 2.3.1.57) e.g. Q28999|ATDA_PIG|SAT from Sus scrofa (Pig) (171 aa), FASTA scores: opt: 152, E(): 0.00025, (23.15% identity in 108 aa overlap)." /codon_start=1 /transl_table=11 /product="POSSIBLE ACETYLTRANSFERASE" /protein_id="CAB08300.1" /db_xref="GI:2072669" /db_xref="GOA:O05850" /db_xref="InterPro:IPR000182" /db_xref="UniProtKB/TrEMBL:O05850" /translation="MRGHVAEVNGGVAAMALWFLNFSTWDGVAGIYVEDLFVWPRFRR RGLARGLLSTLARECVDNRYTRLAWSVLNWNSDAIALYDRIGGQPQHEWTIYRLSGPR LAALAAPR" gene complement(126141..126572) /locus_tag="Rv3217c" CDS complement(126141..126572) /locus_tag="Rv3217c" /function="UNKNOWN" /note="Rv3217c, (MTCY07D11.09), len: 143 aa. Probable conserved integral membrane protein, equivalent (highly similar but shorter 30 aa) to Q9CCH6|ML0806 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (173 aa). Also similar to others e.g. Q9F3L9|2SC7G11.04 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (152 aa), FASTA scores: opt: 177, E(): 0.00024, (33.8% identity in 136 aa overlap). And shows similarity to O34238|MVIN|VC0680 VIRULENCE FACTOR MVIN HOMOLOG from Vibrio (525 aa), FASTA scores: opt: 126, E(): 0.97, (30.9% identity in 68 aa overlap). First GTG taken." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" /protein_id="CAB08299.1" /db_xref="GI:2072668" /db_xref="UniProtKB/TrEMBL:O05849" /translation="MPVRAPAAVRGAGLIVAVQGGAALVVAAALLVRGLAGADQHIVN GLGTAGWFVLVGGAVLAAGCRLAVGKLWGRGLAVFAQLLLLPVAWYLIVGSHQPAIGI PVGIIALGVLVLLFSPPSIRWAAGRDQRGAASAANRGPDSR" gene 126805..127770 /locus_tag="Rv3218" CDS 126805..127770 /locus_tag="Rv3218" /function="UNKNOWN" /note="Rv3218, (MTCY07D11.08c), len: 321 aa. Conserved hypothetical protein, similar to several hypothetical bacterial proteins e.g. Q9F3M0|2SC7G11.03c from Streptomyces coelicolor (322 aa), FASTA scores: opt: 694, E(): 4.2e-35, (39.95% identity in 328 aa overlap); Q9A0J4|SPY0752 from Streptomyces pyogenes (340 aa), FASTA scores: opt: 187, E(): 0.00033, (30.5% identity in 141 aa overlap); O31502|YERQ from Bacillus subtilis (303 aa), FASTA scores: opt: 184, E(): 0.00045, (34.15% identity in 126 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08319.1" /db_xref="GI:2072667" /db_xref="GOA:O05848" /db_xref="InterPro:IPR001206" /db_xref="UniProtKB/TrEMBL:O05848" /translation="MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGT ELGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLAR ALGISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVE AERDKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTY ANNRPVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVAC LRVTSMGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI" gene 128050..128304 /gene="whiB1" /locus_tag="Rv3219" CDS 128050..128304 /gene="whiB1" /locus_tag="Rv3219" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /standard_name="whmE" /note="Rv3219, (MTCY07D11.07c), len: 84 aa. Probable whiB1 (alternate gene name: whmE), WhiB-like regulatory protein (see citation below), similar to WhiB paralogue of Streptomyces coelicolor. Equivalent to Q9CCH7|WHIB1|ML0804 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (84 aa), FASTA scores: opt: 580, E(): 3.5e-35, (95.25% identity in 84 aa overlap). Highly similar to several e.g. Q9X952|WBLE DEVELOPMENTAL REGULATORY PROTEIN WHIB-PARALOG from Streptomyces coelicolor (85 aa), FASTA scores: opt: 477, E(): 9.2e-28, (75.3% identity in 81 aa overlap); Q9AD55|SCP1.95 PUTATIVE REGULATORY PROTEIN from Streptomyces coelicolor (102 aa), FASTA scores: opt: 383, E(): 6.1e-21, (60.75% identity in 79 aa overlap); Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83 aa), FASTA scores: opt: 346, E(): 2.5e-18, (54.75% identity in 84 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB1" /protein_id="CAB08318.1" /db_xref="GI:2072666" /db_xref="GOA:O05847" /db_xref="InterPro:IPR003482" /db_xref="UniProtKB/TrEMBL:O05847" /translation="MDWRHKAVCRDEDPELFFPVGNSGPALAQIADAKLVCNRCPVTT ECLSWALNTGQDSGVWGGMSEDERRALKRRNARTKARTGV" gene complement(128366..129871) /locus_tag="Rv3220c" CDS complement(128366..129871) /locus_tag="Rv3220c" /EC_number="2.7.3.-" /function="SENSOR PART OF A TWO COMPONENT REGULATORY SYSTEM." /note="Rv3220c, (MTCY07D11.06), len: 501 aa. Probable sensor (probably histidine kinase), equivalent to Q9CCH8|ML0803 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (500 aa). Similar to others e.g. Q9F3M1|2SC7G11.01 PUTATIVE HISTIDINE KINASE (FRAGMENT) from Streptomyces coelicolor (372 aa), FASTA scores: opt: 1038, E(): 7.4e-56, (48.95% identity in 380 aa overlap); Q9A3K5|CC3198 SENSOR HISTIDINE KINASE from Caulobacter crescentus (327 aa), FASTA scores: opt: 311, E(): 1.2e-11, (33.35% identity in 201 aa overlap) (similarity only in C-terminal part for this one); Q9A2T2|CC3474 PUTATIVE SENSOR HISTIDINE KINASE from Caulobacter crescentus (547 aa); etc. C-terminal half shows similarity to many sensor proteins, that respond to various stimuli from Methanobacterium thermoautotrophicum e.g. O26568|MTH468 SENSORY TRANSDUCTION HISTIDINE KINASE (554 aa), FASTA scores: opt: 425, E(): 2.1e-18, (34.0% identity in 244 aa overlap); O26546|MTH446 SENSORY TRANSDUCTION REGULATORY PROTEIN (583 aa), FASTA scores: opt: 380, E(): 1.2e-15, (37.15% identity in 202 aa overlap); O26913|MTH823 SENSORY TRANSDUCTION REGULATORY PROTEIN (677 aa), FASTA scores: opt: 375, E(): 2.7e-15, (35.4% identity in 195 aa overlap); etc. SEEMS SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES." /codon_start=1 /transl_table=11 /product="PROBABLE TWO COMPONENT SENSOR KINASE" /protein_id="CAB08317.1" /db_xref="GI:2072665" /db_xref="GOA:O05846" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011495" /db_xref="UniProtKB/TrEMBL:O05846" /translation="MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWV RRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQN SCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEG TFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDA TRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAI LIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIE SVRRVSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLD SDRATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGF SLEKSDSLGLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML" gene complement(129888..130103) /gene="TB7.3" /locus_tag="Rv3221c" CDS complement(129888..130103) /gene="TB7.3" /locus_tag="Rv3221c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3, Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium leprae (70 aa), FASTA scores: opt: 367, E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM BIOTINYLATED PROTEIN TB7.3 HOMOLOG from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341, E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G BIOTIN CARBOXYLASE from Halobacterium sp. strain NRC-1 (610 aa), FASTA scores: opt: 212, E(): 4e-07, (50.0% identity in 68 aa overlap); Q58628|PYCB_METJA|MJ1231 PYRUVATE CARBOXYLASE SUBUNIT B from Methanococcus jannaschii (567 aa), FASTA scores: opt: 192, E(): 7.8e-06, (44.8% identity in 58 aa overlap); Q9ZAA7|GCDC GLUTACONYL-CoA DECARBOXYLASE GAMMA SUBUNIT from Acidaminococcus fermentans (145 aa), FASTA scores: opt: 184, E(): 8.9e-06, (39.4% identity in 66 aa overlap); etc." /codon_start=1 /transl_table=11 /product="BIOTINYLATED PROTEIN TB7.3" /protein_id="CAB08316.1" /db_xref="GI:2072664" /db_xref="GOA:P0A510" /db_xref="UniProtKB/Swiss-Prot:P0A510" /translation="MAEDVRAEIVASVLEVVVNEGDQIDKGDVVVLLESMKMEIPVLA EAAGTVSKVAVSVGDVIQAGDLIAVIS" gene complement(130388..130693) /locus_tag="Rv3221A" CDS complement(130388..130693) /locus_tag="Rv3221A" /function="BINDS SIGMA FACTOR AND INHIBITS IT. PROBABLY INVOLVED IN SURVIVAL FOLLOWING HEAT SHOCK AND OXIDATIVE STRESS." /note="Rv3221A, len: 101 aa. Possible anti-sigma factor, similar to Q9XCD7|AAD41811.1 unknown protein from Mycobacterium smegmatis, linked to sigma factor sigH (see Fernandes et al., 1999) (101 aa), FASTA scores: opt: 422, E(): 3.4e-22, (64.9% identity in 94 aa overlap); and to Q9RL96|RsrA anti-sigma factor from Streptomyces coelicolor (see Kang et al., 1999) (105 aa), FASTA scores: opt: 163, E(): 0.00016, (32.05% identity in 78 aa overlap)." /codon_start=1 /transl_table=11 /product="POSSIBLE ANTI-SIGMA FACTOR" /protein_id="CAE55569.1" /db_xref="GI:38490340" /db_xref="UniProtKB/TrEMBL:Q8VJ46" /translation="MSENCGPTDAHADHDDSHGGMGCAEVIAEVWTLLDGECTPETRE RLRRHLEACPGCLRHYGLEERIKALIGTKCRGDRAPEGLRERLRLEIRRTTIIRGGP" gene complement(130690..131241) /locus_tag="Rv3222c" CDS complement(130690..131241) /locus_tag="Rv3222c" /function="UNKNOWN" /note="Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 GLYCINE-RICH PROTEIN LIKE from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 PUTATIVE TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6, (36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% identity in 170 aa overlap); AAK45760|MT1497.1 PE_PGRS FAMILY PROTEIN from strain CDC1551 (1408 aa), FASTA scores: opt: 137, E(): 2, (31.75% identity in 148 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08315.1" /db_xref="GI:2072663" /db_xref="UniProtKB/TrEMBL:O05844" /translation="MSSPVSSRRLANLVKESLQGSVLGGVVSDAVLPAVSDDVKPGAG EDAYRVPVVVAAGSGAVVQVGGLEVGSAAVAGEVADTVAELFVCRPTEPDVGDFVGLA GGAGDAGQAGQQFGLGVGVRGESFGARRRLALSTVGASGATAGLRKTHDGHHGCQARG ALTQRRLYIGNPSEITDTRMVHQ" gene complement(131238..131888) /gene="sigH" /locus_tag="Rv3223c" CDS complement(131238..131888) /gene="sigH" /locus_tag="Rv3223c" /function="ALTERNATIVE SIGMA FACTOR THAT PLAYS A ROLE IN THE OXIDATIVE-STRESS RESPONSE (REGULATION OF THIOREDOXIN RECYCLING). THE SIGMA FACTOR IS AN INITIATION FACTOR THAT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC INITIATION SITES AND THEN IS RELEASED. THIS SIGMA FACTOR IS INVOLVED IN HEAT SHOCK AND OXIDATIVE STRESS RESPONSE; IT IS BELIEVED TO CONTROL PROTEIN PROCESSING IN THE EXTRACYTOPLASMIC COMPARTMENT. REGULATES POSITIVELY DNAK AND CLPB GENES. REGULATES TRXB2, TRXC, Rv2466c AND SIGB GENES, AND PROBABLY SIG B GENE. SIGH MAY MEDIATE THE TRANSCRIPTION OF AT LEAST 31 GENES DIRECTLY AND MODULATES THE EXPRESSION OF ABOUT 150 OTHERS." /standard_name="rpoE" /experiment="experimental evidence, no additional details recorded" /note="Rv3223c, (MTCY07D11.03), len: 216 aa. sigH (alternate gene name: rpoE), alternative RNA polymerase sigma factor (see citations below), similar to many e.g. Q9XCD8|SIGH from Mycobacterium smegmatis (215 aa), FASTA scores: opt: 1187, E(): 8.1e-69, (87.75% identity in 212 aa overlap); O87834|SIGR from Streptomyces coelicolor (227 aa), FASTA scores: opt: 913, E(): 2.6e-51, (68.8% identity in 202 aa overlap); O68520|RPOE1 from Myxococcus xanthus (213 aa), FASTA scores: opt: 452, E(): 6.7e-22, (42.8% identity in 187 aa overlap); Q06198|RPSH_PSEAE|ALGU|ALGT|PA0762 from Pseudomonas aeruginosa (193 aa), FASTA scores: opt: 301, E(): 2.7e-12, (29.9% identity in 194 aa overlap); etc. Equivalent to AAK47662 RNA polymerase sigma-70 factor from Mycobacterium tuberculosis strain CDC1551 (284 aa), but shorter 68 aa. Has sigma-70 factors ECF subfamily signature (PS01063). So BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. Start chosen on basis of similarity, other potential starts upstream." /codon_start=1 /transl_table=11 /product="ALTERNATIVE RNA POLYMERASE SIGMA-E FACTOR (SIGMA-24) SIGH (RPOE)" /protein_id="CAB08314.1" /db_xref="GI:2072662" /db_xref="GOA:P66807" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009043" /db_xref="UniProtKB/Swiss-Prot:P66807" /translation="MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGA LRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPA EYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYAD VEGFPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS" misc_feature complement(131691..131729) /gene="sigH" /locus_tag="Rv3223c" /note="PS01063 Sigma-70 factors ECF subfamily signature" gene 132188..133036 /locus_tag="Rv3224" CDS 132188..133036 /locus_tag="Rv3224" /EC_number="1.-.-.-" /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR METABOLISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase (EC 1.-.-.-), highly similar to BAB49551|MLL2413 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59, (57.95% identity in 276 aa overlap); Q9AB34|CC0400 SHORT CHAIN DEHYDROGENASE FAMILY PROTEIN from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59, (55.9% identity in 281 aa overlap); and Q9VB10|CG5590 HYPOTHETICAL PROTEIN (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Drosophila melanogaster (Fruit fly) (412 aa), FASTA scores: opt: 966, E(): 2.5e-53, (52.15% identity in 278 aa overlap). Similar to various proteins (principaly oxidoreductases) e.g. Q18639|C45B11.3 HYPOTHETICAL PROTEIN (SIMILAR TO THE SDR FAMILY) from Caenorhabditis elegans (293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3% identity in 271 aa overlap); Q9HZV5|PA2892 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (274 aa), FASTA scores: opt: 847, E(): 5.1e-46, (49.25% identity in 274 aa overlap); Q9I6V0|PA0182 PROBABLE SHORT-CHAIN DEHYDROGENASE (SIMILAR TO THE SDR FAMILY) from Pseudomonas aeruginosa (250 aa), FASTA scores: opt: 333, E(): 8.3e-14, (29.8% identity in 245 aa overlap); Q9HY98|PA3511 PROBABLE SHORT-CHAIN DEHYDROGENASE from Pseudomonas aeruginosa (253 aa), FASTA scores: opt: 330, E(): 1.3e-13, (31.2% identity in 250 aa overlap); etc. Related proteins in Mycobacterium tuberculosis include MTCY02B10.14, MTCY369.14, and MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017) near C-terminus. MAY BE BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." /codon_start=1 /transl_table=11 /product="POSSIBLE IRON-REGULATED SHORT-CHAIN DEHYDROGENASE/REDUCTASE" /protein_id="CAB08313.1" /db_xref="GI:2072661" /db_xref="GOA:O05842" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR002347" /db_xref="UniProtKB/TrEMBL:O05842" /translation="MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPK LPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINL GSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPT AYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPE VYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANP PGYLPA" misc_feature 132881..132904 /locus_tag="Rv3224" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene 132972..133160 /locus_tag="Rv3224A" CDS 132972..133160 /locus_tag="Rv3224A" /function="UNKNOWN" /note="Rv3224A, len: 62 aa. Conserved hypothetical protein (possibly gene fragment), overlaps Rv3224. Similar to N-terminus of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 104, E(): 0.78, (59.37% identity in 32 aa overlap). Note that upstream ORF Rv3224B is similar to C-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAE55570.1" /db_xref="GI:38490341" /db_xref="UniProtKB/TrEMBL:Q6MWZ5" /translation="MRRSASTCGWKTPTRRGTSRPSDSKTLILELPDERAVAIVPVPS KLSLKAAGGPRGAQSGHG" gene 133138..133356 /locus_tag="Rv3224B" CDS 133138..133356 /locus_tag="Rv3224B" /function="UNKNOWN" /note="Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAE55571.1" /db_xref="GI:38490342" /db_xref="InterPro:IPR007214" /db_xref="UniProtKB/TrEMBL:Q6MWZ4" /translation="MPKAAMAKPAAAEQATGYVVGGISPFGQRKRLRTVVDVSALSWD RVLRCRQTALGRHGGPAGPDHLDQRDHR" gene complement(133353..134777) /locus_tag="Rv3225c" CDS complement(133353..134777) /locus_tag="Rv3225c" /EC_number="2.-.-.-" /function="UNKNOWN" /note="Rv3225c, (MTCY07D11.01), len: 474 aa (start uncertain). Possible transferase (EC 2.-.-.-). C-terminal part shows some similarity to various bacterial proteins e.g. BAB49093|MLL1809 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (298 aa), FASTA scores: opt: 557, E(): 2.8e-26, (34.55% identity in 295 aa overlap); P14509|KKA8_ECOLI|APHA AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE from Escherichia coli (271 aa), FASTA scores: opt: 194, E(): 0.00018, (27.75% identity in 227 aa overlap); Q53826|CPH CAPREOMYCIN PHOSPHOTRANSFERASE from Streptomyces capreolus (281 aa), FASTA scores: opt: 178, E(): 0.0017, (30.5% identity in 269 aa overlap); Q9CDM4|YWIA UNKNOWN PROTEIN from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (213 aa), FASTA scores: opt: 167, E(): 0.0061, (2705% identity in 149 aa overlap); Q9X843|SC9B1.24 PUTATIVE TRANSFERASE (FRAGMENT) from Streptomyces coelicolor (317 aa), FASTA scores: opt: 165, E(): 0.011, (26.05% identity in 280 aa overlap); etc." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSFERASE" /protein_id="CAB08321.1" /db_xref="GI:3261741" /db_xref="GOA:O05841" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR002575" /db_xref="UniProtKB/TrEMBL:O05841" /translation="MRFAKLSDGLSDGIVTLSPLCLDDVDAHLAGGDERLVRWLSGMP STRASVEAYIRHCREQWVTGGPLRSFGIRTVAETIVGTIDLRFDGEGLASGQVNVAYG LYPSWRGRGLATRAVDLVCQYAAEHGATEAVIKVEPENSASARVALRAGFAFVRRICE QDGTVFDRYERVLRAKMHADEVDIDEDLVRRLLRAQFPQWADLPIAPVRSAGTDNAMY RLGEDLAVRIPRIGWAIESLRTEQQWLPRIAAHLGVASPVPVGLGSPAEGFGWPWSVC RWVAGENPSAAEFVEPNRAVEDLADFITALRATDPMGGPPAKRGAPLGEQDAEVRAAL AALDGIIDVHAATAAWESALRVPPYAGPPMWFHGDLSRFNILTAQGRLTGVIDFGLMG VGDPSVDLIIAWNLLSAPARAQFRVAVGAADDDWMRGRGRALAIALIALPYYQDTNPP LAASARYAIGEVLADFRYGARPGC" gene complement(134901..135659) /locus_tag="Rv3226c" CDS complement(134901..135659) /locus_tag="Rv3226c" /function="UNKNOWN" /note="Rv3226c, (MTCY20B11.01c), len: 252 aa. Conserved hypothetical protein, similar to various hypothetical bacterial proteins e.g. Q9CCI2|ML0793 PUTATIVE BACTERIOPHAGE PROTEIN from Mycobacterium leprae (252 aa), FASTA scores: opt: 1183, E(): 3.8e-68, (70.65% identity in 252 aa overlap); BAB54183|MLR7795 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (369 aa), FASTA scores: opt: 417, E(): 2.9e-19, (33.75% identity in 252 aa overlap); O64131 YOQW PROTEIN from Bacteriophage SPBc2 (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O31916 YOQW PROTEIN from Bacillus subtilis (224 aa), FASTA scores: opt: 413, E(): 3.4e-19, (38.5% identity in 244 aa overlap); O34906 YOAM PROTEIN from Bacillus subtilis (227 aa), FASTA scores: opt: 401, E(): 2e-18, (37.7% identity in 244 aa overlap); Q9K4A5|SC7E4.11 HYPOTHETICAL 30.8 KDA PROTEIN from Streptomyces coelicolor (271 aa), FASTA scores: opt: 383, E(): 3.3e-17, (39.6% identity in 283 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08327.1" /db_xref="GI:2072693" /db_xref="InterPro:IPR003738" /db_xref="UniProtKB/TrEMBL:O05872" /translation="MCGRFAVTTDPAQLAEKITAIDEATGCGGGKTSYNVAPTDTIAT VVSRHSEPDDEPTRRVRLMRWGLIPSWIKAGPGGAPDAKGPPLINARADKVATSPAFR SAVRSKRCLVPMDGWYEWRVDPDATPGRPNAKTPFFLHRHDGALLFTAGLWSVWKSYR SAPPLLSCTVITTDAVGELAEIHDRMPLLLAEEDWDDWLNPDAPPDPELLARPPDVRD IALRQVSTLVNNVRNNGPELLEPARSQPEQIQLL" gene 135714..137066 /gene="aroA" /locus_tag="Rv3227" CDS 135714..137066 /gene="aroA" /locus_tag="Rv3227" /EC_number="2.5.1.19" /function="INVOLVED IN THE BIOSYNTHESIS OF CHORISMATE WITHIN THE BIOSYNTHESIS OF AROMATIC AMINO ACIDS (THE SHIKIMATE PATHWAY). ACTS IN THE SIXTH STEP OF THIS PATHWAY. [CATALYTIC ACTIVITY: PHOSPHOENOLPYRUVATE + 3-PHOSPHOSHIKIMATE = ORTHOPHOSPHATE + O(5)-(1-CARBOXYVINYL)-3-PHOSPHOSHIKIMATE]." /experiment="experimental evidence, no additional details recorded" /note="Rv3227, (MTCY20B11.02), len: 450 aa. aroA, 3-phosphoshikimate 1-carboxyvinyl transferase (EC 2.5.1.19) (see citation below), equivalent (but C-terminus longer) to Q9CCI3|AROA|ML0792 PUTATIVE 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYL TRANSFERASE from Mycobacterium leprae (430 aa), FASTA scores: opt: 1466, E(): 1.4e-78, (55.05% identity in 427 aa overlap). Contains PS00885 EPSP synthase signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY." /codon_start=1 /transl_table=11 /product="3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE AROA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS)" /protein_id="CAB08328.1" /db_xref="GI:2072694" /db_xref="GOA:P22487" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="UniProtKB/Swiss-Prot:P22487" /translation="MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGRGAS TISGALRSRDTELMLDALQTLGLRVDGVGSELTVSGRIEPGPGARVDCGLAGTVLRFV PPLAALGSVPVTFDGDQQARGRPIAPLLDALRELGVAVDGTGLPFRVRGNGSLAGGTV AIDASASSQFVSGLLLSAASFTDGLTVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDST PNRWQVRPGPVAARRWDIEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAI LRQLNAVVIHADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGI AHLRGHETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHRMAMAGAI IGLRVAGVEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPRSGQRARRATGQGSGG " misc_feature 136725..136781 /gene="aroA" /locus_tag="Rv3227" /note="PS00885 EPSP synthase signature 2" gene 137063..138055 /locus_tag="Rv3228" CDS 137063..138055 /locus_tag="Rv3228" /function="UNKNOWN" /note="Rv3228, (MTCY20B11.03), len: 330 aa. Conserved hypothetical protein, equivalent to Q9CCI4|ML0791 HYPOTHETICAL PROTEIN from Mycobacterium leprae (327 aa), FASTA scores: opt: 1828, E(): 1e-98, (84.0% identity in 331 aa overlap). Also similar to several hypothetical bacterial proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces coelicolor (337 aa), FASTA scores: opt: 1051, E(): 1e-53, (52.65% identity in 338 aa overlap); Q9HUL3|PA4952 from Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 392 ,E(): 1.4e-15, (34.85% identity in 281 aa overlap); Q9PFV1|XF0556 from Xylella fastidiosa (341 aa), FASTA scores: opt: 367, E(): 4e-14, (36.85% identity in 247 aa overlap); P45339|YJEQ_HAEIN|HI1714 from Haemophilus influenzae (346 aa), FASTA scores: opt: 355, E(): 2e-13, (31.65% identity in 281 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08329.1" /db_xref="GI:2072695" /db_xref="GOA:O05873" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="UniProtKB/TrEMBL:O05873" /translation="MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGR WGCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVL RRTADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKT DLAPAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLV PEADRAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVL LAFSDLAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT" misc_feature 137672..137695 /locus_tag="Rv3228" /note="PS00017 ATP/GTP-binding site motif A" gene complement(138088..139371) /locus_tag="Rv3229c" CDS complement(138088..139371) /locus_tag="Rv3229c" /EC_number="1.14.19.3" /function="THOUGHT TO BE INVOLVED IN LIPID METABOLISM [CATALYTIC ACTIVITY: LINOLEOYL-CoA + AH(2) + O(2) = GAMMA-LINOLENOYL-CoA + A + 2 H(2)O]" /standard_name="desA3" /experiment="experimental evidence, no additional details recorded" /note="Rv3229c, (MTCY20B11.04c), len: 427 aa. Possible linoleoyl-CoA desaturase (EC 1.14.99.25), showing similarity with desaturases and other proteins e.g. Q08871|DES6|SLL0262 LINOLEOYL-CoA DESATURASE from Synechocystis sp. strain PCC 6803 (359 aa), FASTA scores: opt: 319, E(): 4e-13, (25.1% identity in 295 aa overlap); Q54795|DESD DELTA 6 DESATURASE from Spirulina platensis (368 aa), FASTA scores: opt: 268, E(): 7.7e-10, (25.0% identity in 300 aa overlap); Q9ZTU8|S276 PROTEIN WITH SIMILARITY TO CYTOCHROME B5 DOMAIN from Triticum aestivum (Wheat) (469 aa), FASTA scores: opt: 240, E(): 5.9e-08, (27.05% identity in 266 aa overlap); etc. Note that previously known as desA3." /codon_start=1 /transl_table=11 /product="POSSIBLE LINOLEOYL-CoA DESATURASE (DELTA(6)-DESATURASE)" /protein_id="CAE55572.1" /db_xref="GI:38490343" /db_xref="GOA:Q7D5W1" /db_xref="InterPro:IPR005804" /db_xref="InterPro:IPR010257" /db_xref="UniProtKB/TrEMBL:Q7D5W1" /translation="MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIR RTIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWMND PEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVTRDQRWKRYNI FNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVA FPALTSLSPGATYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKG QWYLRQMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYD LPYTTGSFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPV TGRRRGLKTAIAAVRGRRRSKRMAKSVTEPDDLAA" gene complement(139449..140591) /locus_tag="Rv3230c" CDS complement(139449..140591) /locus_tag="Rv3230c" /EC_number="1.-.-.-" /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR METABOLISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3230c, (MTCY20B11.05c), len: 380 aa. Putative oxidoreductase (EC 1.-.-.-), with some similarity to various proteins, especially reductases e.g. Q9HUS4|PA4889 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (366 aa), FASTA scores: opt: 516, E(): 1.8e-24, (33.8% identity in 367 aa overlap); P95533|TDNB ELECTRON TRANSFER PROTEIN from Pseudomonas putida (337 aa), FASTA scores: opt: 380, E(): 4e-16, (30.7% identity in 277 aa overlap); BAB34381|ECS0958 NADH OXIDOREDUCTASE FOR THE HCP from Escherichia coli strain O157:H7 (322 aa), FASTA scores: opt: 369, E(): 1.8e-15, (28.65% identity in 328 aa overlap); Q44253|ATDA5 ANILINE DIOXYGENASE REDUCTASE COMPONENT from Acinetobacter sp. (336 aa), FASTA scores: opt: 305, E(): 1.6e-11, (27.4% identity in 303 aa overlap); etc." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL OXIDOREDUCTASE" /protein_id="CAB08331.1" /db_xref="GI:2072697" /db_xref="GOA:O05875" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR008333" /db_xref="UniProtKB/TrEMBL:O05875" /translation="MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLL PDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLV DGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGN FVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELA ALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSA GASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCR MGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI" gene complement(140701..141210) /locus_tag="Rv3231c" CDS complement(140701..141210) /locus_tag="Rv3231c" /function="UNKNOWN" /note="Rv3231c, (MTCY20B11.06c), len: 169 aa. Hypothetical protein, similar to Q9KYX9|SCE33.03c HYPOTHETICAL 17.4 KDA PROTEIN from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08332.1" /db_xref="GI:2072698" /db_xref="UniProtKB/TrEMBL:O05876" /translation="MTQVYIPATLAMLQRLVADGALWPVNGTAFAVTPTLRESYAEGD DEELAEVALREAALASLRLLAADIGATADALPPRRAVLAAEVDDATYRPDLDDAVVRL AGPITIDQVVAAYVDNAGAEPAVMAAIAVIDAADLGDEDAELVVGDAQDHDLAWYANQ ELPFLLDLL" gene complement(141207..142094) /gene="pvdS" /locus_tag="Rv3232c" CDS complement(141207..142094) /gene="pvdS" /locus_tag="Rv3232c" /function="POSSIBLY INVOLVED IN TRANSCRIPTIONAL MECHANISM (PROBABLY SIGMA FACTOR PROMOTING ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC INITIATION SITES)." /note="Rv3232c, (MTCY20B11.07c), len: 295 aa (start uncertain). Possible pvdS, an alternative RNA polymerase sigma factor, highly similar (but N-terminus longer 25-50 residues approximatively) to Q9RIZ9|SCJ1.15 PUTATIVE REGULATOR from Streptomyces coelicolor (267 aa), FASTA scores: opt: 1189, E(): 1.4e-70, (65.65% identity in 262 aa overlap); Q9KU02|VC0728 HYPOTHETICAL PROTEIN from Vibrio cholerae (258 aa), FASTA scores: opt: 1074, E(): 4.5e-63, (62.6% identity in 254 aa overlap); P72119|PVDS PAO SUBSTRAIN OT684 PYOVERDINE GENE TRANSCRIPTIONAL REGULATOR PVDS (FRAGMENT) from Pseudomonas aeruginosa (see citations below) (237 aa), FASTA scores: opt: 988, E(): 1.8e-57, (60.8% identity in 227 aa overlap). Also highly similar to Q9I154|PA2428 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (304 aa), FASTA scores: opt: 1057, E(): 6.8e-62, (60.7% identity in 252 aa overlap); Q9I6Z1|PA0141 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 990, E(): 1.6e-57, (54.6% identity in 249 aa overlap); and other hypothetical bacterial proteins. Could be a member of a subfamily of RNA polymerase sigma factors which direct the synthesis of extracellular products by bacteria." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN PVDS (PROBABLE RNA POLYMERASE SIGMA FACTOR)" /protein_id="CAB08333.1" /db_xref="GI:2072699" /db_xref="InterPro:IPR005660" /db_xref="UniProtKB/TrEMBL:O05877" /translation="MDIPSVDVSTATNDGASSRAKGHRSAAPGRRKISDAVYQAELFR LQTEFVKLQEWARHSGARLVVIFEGRDGAGKGGAIKRITEYLNPRVARIAALPAPTDR ERGQWYYQRYIAHLPAKGEIVLFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQM LIDDGILLRKYWFSVSDAEQLRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEM MVHTDTPVSPWYVVESDIKKHARLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGNYRR PPRELSTYVDDYVATLIAR" gene complement(142118..142708) /locus_tag="Rv3233c" CDS complement(142118..142708) /locus_tag="Rv3233c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3233c, (MTCY20B11.08c), len: 196 aa. Hypothetical protein, similar to C-terminus of Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from Streptomyces coelicolor (446 aa), FASTA scores: opt: 308, E(): 1.2e-12, (32.0% identity in 200 aa overlap); and several hypothetical M. tuberculosis proteins e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa), FASTA scores: opt: 248, E(): 9.8e-09, (27.5% identity in 200 aa overlap); MTCY28_26; MTCY493_29; MTCY31_25; MTCY31_25." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08334.1" /db_xref="GI:2072700" /db_xref="UniProtKB/TrEMBL:O05878" /translation="MIAGALGNWLMSRGEAVAPTATVRAMAPLSVYADDQLDSTGPGQ AISQVTPFLVDLPVGEGNAVVRLSQIAHATESNPTAASLVDARTIVTLSGLAPATLHA MGVRVATSFSARLFNLLITNAPGTQSQMYIAGTKLLETYSVPPLLHNQALAISVTSYN GMLYFGINADRDAMSDVDLLPGLLSQALDELLEASR" gene complement(142711..143526) /locus_tag="Rv3234c" CDS complement(142711..143526) /locus_tag="Rv3234c" /function="UNKNOWN" /note="Rv3234c, (MTCY20B11.09c), len: 271 aa. Hypothetical protein, similar to C-terminus of Mycobacterium tuberculosis hypothetical proteins e.g. P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26; MTV013_8; MTY13E12_33; etc. Also similar to Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from Mycobacterium leprae (491 aa), FASTA scores: opt: 309, E(): 4.3e-12, (33.35% identity in 189 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08335.1" /db_xref="GI:2072701" /db_xref="GOA:O05879" /db_xref="InterPro:IPR004255" /db_xref="UniProtKB/Swiss-Prot:O05879" /translation="MVTRLSASDASFYQLENTATPMYVGLLLILRRPRAGLSYEALLE TVEQRLPQIPRYRQKVQEVKLGLARPVWIDDRDFDITYHVRRSALPSPGSDEQLHELI ARLAARPLDKSRPLWEMYLVEGLEKNRIALYTKSHQALINGVTALAIGHVIADRTRRP PAFPEDIWVPERDPGTTRLLLRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRK VLDIARTVARGTAPSSPLNATVSRNRRFTVARASLDDYRTVRARYDCDSTTWC" gene 143637..144278 /locus_tag="Rv3235" CDS 143637..144278 /locus_tag="Rv3235" /function="UNKNOWN" /note="Rv3235, (MTCY20B11.10), len: 213 aa. Hypothetical unknown ala-, arg-, pro-rich protein." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL ALANINE ARGININE PROLINE RICH PROTEIN" /protein_id="CAB08336.1" /db_xref="GI:2072702" /db_xref="UniProtKB/TrEMBL:O05880" /translation="MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTF AVTPVVEYEPPPRNIPPCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRL RQAGTFADAALRRVLEVIDRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRR IRLTPAGPDTADTAAEVFGTYSRGDRIHAIACRVEQRPAGNETRWLMVALHIG" gene complement(144296..145453) /locus_tag="Rv3236c" CDS complement(144296..145453) /locus_tag="Rv3236c" /function="PROBABLY INVOLVED IN TRANSPORT OF UNDETERMINATED SUBSTRATE (POSSIBLY CATIONS Na/H) ACROSS THE MEMBRANE. THOUGHT TO BE RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." /standard_name="kefB" /note="Rv3236c, (MTCY20B11.11c), len: 385 aa. Probable conserved integral membrane transport protein, possibly cation (Na/H) transporter, equivalent to Q9CCI5|ML0782 putative transmembrane transport protein from Mycobacterium leprae (385 aa), FASTA scores: opt: 1975, E(): 2.4e-108, (81.55% identity in 385 aa overlap). Highly similar to others e.g. O69958|SC4H2.03c putative transmembrane transport protein from Streptomyces coelicolor (411 aa), FASTA scores: opt: 1226, E(): 1.6e-64, (53.5% identity in 372 aa overlap); Q9XAKO|SC66T3.13c putative transmembrane transport protein from Streptomyces coelicolor (403 aa), FASTA scores: opt: 1198, E(): 6.8e-63, (53.25% identity in 370 aa overlap); Q9RV80|DR1149 putative Na+/H+ antiporter from Deinococcus radiodurans (383 aa), FASTA scores: opt: 1069, E(): 2.3e-55, (47.35% identity in 376 aa overlap); Q9L191|SC10G8.11 putative transmembrane transport protein from Streptomyces coelicolor (446 aa), FASTA scores: opt: 695, E(): 1.9e-33, (38.05% identity in 384 aa overlap); Q9RRW8|DR2367 putative glutathione-regulated potassium-efflux system protein KEFB from Deinococcus radiodurans (575 aa), FASTA scores: opt: 414, E(): 6.2e-17, (30.25% identity in 380 aa overlap); etc. SEEMS TO BELONG TO THE CPA2 FAMILY. Note that previously known as kefB." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN" /protein_id="CAE55573.1" /db_xref="GI:38490344" /db_xref="UniProtKB/TrEMBL:Q7D5V5" /translation="MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLG NGGILGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLRHHLPSAGVDIVLNAT PGAVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDF AMAAYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPDSEQL LLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRARMVLTPLRDLFATIFFL GIGLSVDPGKLVSMLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARG EFSLIIIGLAGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN" gene complement(145458..145940) /locus_tag="Rv3237c" CDS complement(145458..145940) /locus_tag="Rv3237c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3237c, (MTCY20B11.12c), len: 160 aa. Conserved hypothetical protein, equivalent to Q9CCI6|ML0781 HYPOTHETICAL PROTEIN from Mycobacterium leprae (160 aa), FASTA scores: opt: 828, E(): 1.5e-45, (80.6% identity in 160 aa overlap); and similar to other hypothetical bacterial proteins and more weakly to putative potassium channels e.g. Q9RV81|DR1148 CONSERVED HYPOTHETICAL PROTEIN from Deinococcus radiodurans (175 aa), FASTA scores: opt: 420, E(): 9.5e-20, (37.95% identity in 158 aa overlap); O69959|SC4H2.04c HYPOTHETICAL 17.1 KDA PROTEIN from Streptomyces coelicolor (161 aa), FASTA scores: opt: 315, E(): 3.8e-13, (40.0% identity in 150 aa overlap); Q9HNH3|PCHB|VNG2104G POTASSIUM CHANNEL HOMOLOG from Halobacterium sp. strain NRC-1 (418 aa), FASTA scores: opt: 158, E(): 0.007, (31.45% identity in 124 aa overlap); Q58752|YD57_METJA|MJ1357 PUTATIVE POTASSIUM CHANNEL PROTEIN from Methanococcus jannaschii (343 aa), FASTA scores: opt: 143, E(): 0.053, (33.8% identity in 68 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08338.1" /db_xref="GI:2072704" /db_xref="GOA:O05882" /db_xref="InterPro:IPR006037" /db_xref="UniProtKB/TrEMBL:O05882" /translation="MDVKEVLLPGVGLRYEFTSYRGDRIGIVARRSGGFDVVLYGRDD PDEARPVLRLTDEEAEAVAQILGAPRIAERFTELTREVPGLKAGQIHIRAGSLFVDRP LGDTRARTRTGASIVAIVRDEDVLASPGPTDVLRAGDVLIVIGTEDGIAGVEQIVEKG " gene complement(146001..146735) /locus_tag="Rv3238c" CDS complement(146001..146735) /locus_tag="Rv3238c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3238c, (MTCY20B11.13c), len: 244 aa. Probable conserved integral membrane protein, similar to several hypothetical proteins and transmembrane proteins e.g. Q9UN92|NRM29 MULTISPANNING NUCLEAR ENVELOPE MEMBRANE PROTEIN NURIM (FRAGMENT) from Homo sapiens (Human) (261 aa), FASTA scores: opt: 281, E(): 3.3e-11, (30.7% identity in 189 aa overlap); Q9VEG9|CG7655 HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit fly) (253 aa), FASTA scores: opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa overlap); BAB48937|MLR1600 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (222 aa), FASTA scores: opt: 137, E(): 0.066, (28.1% identity in 185 aa overlap); BAB57936|SAV1774 AESENICAL PUMP MEMBRANE PROTEIN HOMOLOG from Staphylococcus aureus subsp. aureus Mu50 (430 aa), FASTA scores: opt: 125, E(): 0.68, (25.7% identity in 144 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" /protein_id="CAB08339.1" /db_xref="GI:2072705" /db_xref="UniProtKB/TrEMBL:O05883" /translation="MKRYLTIIYGAASYLVFLVAFGYAIGFVGDVVVPRTVDHAIAAP IGQAVVVNLVLLGVFAVQHSVMARQGFKRWWTRFVPPSIERSTYVLLASVALLLLYWQ WRTMPAVIWDVRQPAGRVALWALFWLGWATVLTSTFMINHFELFGLRQVYLAWRGKPY TEIGFQAHLLYRWVRHPIMLGFVVAFWATPMMTAGHLLFAIGATGYILVALQFEERDL LAALGDQYRDYRREVSMLLPWPHRHT" gene complement(146794..149940) /locus_tag="Rv3239c" CDS complement(146794..149940) /locus_tag="Rv3239c" /function="UNKNOWN, BUT SEEMS INVOLVED IN EFFLUX SYSTEM (PROBABLY SUGAR OR DRUG TRANSPORT)." /note="Rv3239c, (MTCY20B11.14c), len: 1048 aa. Probable conserved transmembrane protein, organised in two domains. Domain comprising first ~500 aa residues is similar to various antibiotic resistance and efflux proteins and contains sugar transport proteins signature 1 (PS00216); e.g. Q9RL22|SC5G9.04c PUTATIVE TRANSMEMBRANE EFFLUX PROTEIN from Streptomyces coelicolor (489 aa), FASTA scores: opt: 905, E(): 3.1e-41, (36.95% identity in 482 aa overlap); and O68912|FRNF PUTATIVE ANTIBIOTIC ANTIPORTER from Streptomyces roseofulvus (517 aa), FASTA scores: opt: 866, E(): 4.1e-39, (37.1% identity in 512 aa overlap). Second part, corresponding to last 550 aa residues, is very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical 62.1 kDa protein from Mycobacterium tuberculosis (583 aa), FASTA scores: E(): 2.1e-28, (36.5% identity in 572 aa overlap). Also equivalent to Rv3728|MTV025.076 PUTATIVE TWO-DOMAIN MEMBRANE PROTEIN (SIMILAR TO SUGAR TRANSPORTER FAMILY) from Mycobacterium tuberculosis (1065 aa), FASTA scores: opt: 4328, E(): 0, (64.15% identity in 1046 aa overlap); and similar to other Mycobacterium tuberculosis proteins: MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E(): 6.3e-32; MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E(): 2.5e-26. Equivalent to AAK47679 Drug transporter from Mycobacterium tuberculosis strain CDC1551 (1065 aa) but shorter 20 aa. Contains cyclic nucleotide-binding domain signature 2 (PS00889). Probably member of major facilitator superfamily (MFS)." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN" /protein_id="CAB08340.1" /db_xref="GI:2072706" /db_xref="GOA:O05884" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR001411" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR007114" /db_xref="InterPro:IPR011701" /db_xref="UniProtKB/TrEMBL:O05884" /translation="MHISLHGGKGFANLTRRRRPSSASVLLVAGFGAFLAFLDSTIVN IAFPDIQRSFPSYDIGSLSWILNGYNIVFAAFMVAAGRLADLLGRRRTFLSGVLVFTI ASGLCAVAGSVEQLVAFRVLQGIGAAILVPASLALVVEGFDAARRAHAIGLWGAAAAI AAGLGPPIGGLLVEWAGWRWVLLVNVPLGIVAAIATKRMLVESRASGRRRMPDLRGAL LLAVTLGLVTLGLVKGPDWGWLSVATVGSFLASVLTSVGFVHSSRSHPAPLVEPALLR SRSFVAGNLLTLVAAAGFYCYGLTHVLYLNYVWHYSLLKAGFAIAPAAVVAAVVAAAL GRVAGRHGHRVIVLVGALVWAGSLVWYLQRVGSEPDFLRVWLPGQLLQGIGVGATLPV LSSAALAEVAKGGSYATSSAVVSTTRQLGAVLGVAVMVILIGKPEHGTAEEALRRGWA MAAICFIAVAVAAAVLGRTNRNPVQMPAPEPAIAPRLEPPIPQPAAAPIEHWAAGDAD PLGNLPLFAGLDAATLAQLGEHVEDVELEAGCYLFHEGDPSDSLYVIRTGRVQVLQDS IVLKELGRGEVLGELGLLIDAPRSATVRALRDTKLVRLTKAQFDEIADHGALAALVKV LATRLREAPPPATDSTSPEVVVSVIGVSGDAPVPAVAAGLLTALSARLRAVDPGRVDR DGLDRAERVADKVVLHAAVEDAGWRDFCLRVADRIVLVAGDPNPQAARLPARARGADL VLAGPAASREHRRQWEELITPRSVHVVHYRRILENVRPLAARIAGRSIGLVLGGGGAR GFAHLGVLDELERVGVTIDRFAGTSMGAVIAVFGACGMDAATADAYAYEYFIRHNPLS DYAFPVRGLVRGRRTLTLLEAAFGDRLVEELPKEFRCVSVDLLARRPVVHRRGRLVDV IGCSLRLPGIYPPQVYNGRLHVDGGVLDNLPVSTRASPDGPLIAVSIGLGGGGPGSAR QDGSPKVPGIGDTLMRTMTIGSQRGADAALSLAQVVIRPDTGAVGLLEFHQIDAAREA GRVAAREAMPHIMALLNR" misc_feature complement(148156..148209) /locus_tag="Rv3239c" /note="PS00889 Cyclic nucleotide-binding domain signature 2" misc_feature complement(149653..149703) /locus_tag="Rv3239c" /note="PS00216 Sugar transport proteins signature 1" gene complement(150019..152868) /gene="secA1" /locus_tag="Rv3240c" CDS complement(150019..152868) /gene="secA1" /locus_tag="Rv3240c" /function="INVOLVED IN PROTEIN EXPORT. INTERACTS WITH THE SECY/SECE SUBUNITS. SECA HAS A CENTRAL ROLE IN COUPLING THE HYDROLYSIS OF ATP TO THE TRANSFER OF PRE-SECRETORY PERIPLASMIC AND OUTER MEMBRANE PROTEINS ACROSS THE MEMBRANE." /standard_name="secA" /experiment="experimental evidence, no additional details recorded" /note="Rv3240c, (MTCY20B11.15c), len: 949 aa. Probable secA1, preprotein translocase subunit, component of secretion apparatus (see citations below), highly similar to many e.g. P57996|SEA1_MYCLE from Mycobacterium leprae (940 aa), FASTA scores: opt: 5044, E(): 0, (87.5% identity in 849 aa overlap); P95759|SECA_STRGR from Streptomyces griseus (940 aa), FASTA scores: opt: 2612, E(): 1.9e-134, (61.35% identity in 960 aa overlap); P28366|SECA_BACSU|DIV+ from Bacillus subtilis (841 aa), FASTA scores: opt: 1776, E(): 4.9e-89, (48.05% identity in 837 aa overlap); etc. BELONGS TO THE SECA FAMILY. PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Note that previously known as secA." /codon_start=1 /transl_table=11 /product="PROBABLE PREPROTEIN TRANSLOCASE SECA1 1 SUBUNIT" /protein_id="CAE55574.1" /db_xref="GI:38490345" /db_xref="GOA:P0A5Y8" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="UniProtKB/Swiss-Prot:P0A5Y8" /translation="MLSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTD EFKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLGNVAEMK TGEGKTLTCVLPAYLNALAGNGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILATM TPDERRVAYNADITYGTNNEFGFDYLRDNMAHSLDDLVQRGHHYAIVDEVDSILIDEA RTPLIISGPADGASNWYTEFARLAPLMEKDVHYEVDLRKRTVGVHEKGVEFVEDQLGI DNLYEAANSPLVSYLNNALKAKELFSRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGM HQAIEAKEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVS IPTNMPMIREDQSDLIYKTEEAKYIAVVDDVAERYAKGQPVLIGTTSVERSEYLSRQF TKRRIPHNVLNAKYHEQEATIIAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRL RERGLDPVETPEEYEAAWHSELPIVKEEASKEAKEVIEAGGLYVLGTERHESRRIDNQ LRGRSGRQGDPGESRFYLSLGDELMRRFNGAALETLLTRLNLPDDVPIEAKMVTRAIK SAQTQVEQQNFEVRKNVLKYDEVMNQQRKVIYAERRRILEGENLKDQALDMVRDVITA YVDGATGEGYAEDWDLDALWTALKTLYPVGITADSLTRKDHEFERDDLTREELLEALL KDAERAYAAREAELEEIAGEGAMRQLERNVLLNVIDRKWREHLYEMDYLKEGIGLRAM AQRDPLVEYQREGYDMFMAMLDGMKEESVGFLFNVTVEAVPAPPVAPAAEPAELAEFA AAAAAAAQQRSAVDGGARERAPSALRAKGVASESPALTYSGPAEDGSAQVQRNGGGAH KTPAGVPAGASRRERREAARRQGRGAKPPKSVKKR" gene complement(152947..153591) /locus_tag="Rv3241c" CDS complement(152947..153591) /locus_tag="Rv3241c" /function="UNKNOWN, BUT MAY BE INVOLVED IN TRANSDUCTION MECHANISM" /note="Rv3241c, (MTCY20B11.16c), len: 213 aa. Conserved hypothetical protein, similar to many hypothetical proteins and to some putative ribosomal proteins e.g. Q9CCI7|ML0778 HYPOTHETICAL PROTEIN from Mycobacterium leprae (229 aa), FASTA scores: opt: 1234, E(): 1.3e-72, (89.3% identity in 206 aa overlap); Q9KYX2|SCE33.11c HYPOTHETICAL 27.9 KDA PROTEIN from Streptomyces coelicolor (254 aa), FASTA scores: opt: 487, E(): 2.2e-24, (47.6% identity in 210 aa overlap); Q9FLV3 PROTEIN SIMILAR TO RIBOSOMAL PROTEIN 30S SUBUNIT from Arabidopsis thaliana (Mouse-ear cress) (365 aa), FASTA scores: opt: 264, E(): 7e-10, (26.4% identity in 212 aa overlap); P19954|RR30_SPIOL|RPS22 PLASTID-SPECIFIC 30S RIBOSOMAL PROTEIN 1, chloroplast, from Spinacia oleracea (Spinach) (302 aa), FASTA scores: opt: 261, E(): 9.3e-10, (26.15% identity in 214 aa overlap); P47995|YSEA_STACA HYPOTHETICAL PROTEIN IN SECA 5'REGION (ORF1) (FRAGMENT) (BELONGS TO THE S30AE FAMILY OF RIBOSOMAL PROTEINS) from Staphylococcus carnosus (165 aa), FASTA scores: opt: 201, E(): 4.2e-06, (33.35% identity in 147 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08342.1" /db_xref="GI:2072708" /db_xref="InterPro:IPR003489" /db_xref="UniProtKB/TrEMBL:O05886" /translation="MDSGQVLAEPKSNAEIVFKGRNVEIPDHFRIYVSQKLARLERFD RTIYLFDVELDHERNRRQRKSCQRVEITARGRGPVVRGEACADSFYAALESAVVKLES RLRRGKDRRKVHYGDKTPVSLAEATAVVPAPENGFNTRPAEAHDHDGAVVEREPGRIV RTKEHPAKPMSVDDALYQMELVGHDFFLFYDKDTERPSVVYRRHAYDYGLIRLA" gene complement(153907..154548) /locus_tag="Rv3242c" CDS complement(153907..154548) /locus_tag="Rv3242c" /function="UNKNOWN" /note="Rv3242c, (MTCY20B11.17c), len: 213 aa. Conserved hypothetical protein, highly similar in N-terminus to Q9CCI9|ML0776 HYPOTHETICAL PROTEIN from Mycobacterium leprae (85 aa), FASTA scores: opt: 324, E(): 1.7e-13, (78.1% identity in 64 aa overlap). Also similar to Q9RUJ7|DR1389 PUTATIVE COMPETENCE PROTEIN COMF from Deinococcus radiodurans (219 aa), FASTA scores: opt: 223, E(): 6.3e-07, (35.8% identity in 215 aa overlap); BAB50338|MLL3453 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (240 aa), FASTA scores: opt: 218, E(): 1.4e-06, (28.5% identity in 224 aa overlap); Q9A9Y1|CC0830 COMPETENCE PROTEIN F from Caulobacter crescentus (265 aa), FASTA scores: opt: 182, E(): 0.00026, (30.15% identity in 219 aa overlap); etc. Equivalent to AAK47682 from Mycobacterium tuberculosis strain CDC1551 (241 aa) but shorter 29 aa. Contains purine/pyrimidine phosphoribosyl transferases signature (PS00103). SEEMS TO BELONG TO PURINE/PYRIMIDINE PHOSPHORIBOSYL TRANSFERASE FAMILY." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08343.1" /db_xref="GI:2072709" /db_xref="GOA:O05887" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR002375" /db_xref="UniProtKB/TrEMBL:O05887" /translation="MLDLVLPLECGGCGAPATRWCAACAAELSVAAGEPHVVSPRVDP QVPVFALGRYAGVRRQAILAMKEHGRRDLVAPLACALIVGVDHLLSWGMLENPLTMVP APTRRWAARRRGGDPVSRMARIAGATLGRHHDVTVVPALRMRALARDSVGLGASARER NITGRVLLRGQRPRNEVVLVDDIITTGATARESVRVLQAAGVRVGAVLAVAAA" misc_feature complement(153982..154020) /locus_tag="Rv3242c" /note="PS00103 Purine/pyrimidine phosphoribosyl transferases signature" gene complement(154586..155428) /locus_tag="Rv3243c" CDS complement(154586..155428) /locus_tag="Rv3243c" /function="UNKNOWN" /note="Rv3243c, (MTCY20B11.18c), len: 280 aa. Hypothetical unknown protein." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAB08344.1" /db_xref="GI:2072710" /db_xref="UniProtKB/TrEMBL:O05888" /translation="MSPRVPRLRWDDPFRALDMLASLWSSTGMSLVSAGAAQAVAAPY RTLFTTLQQLLIGKEVTVRIGDHDVVLTVTELDSALEPQGLAVGQLGEVRVAARGISW DQHHLHSAVAVLRNVHIRPGVPPLVIAAPVELSSALPTEIFDDVLRQATPQLRGELSE SGAARLRWARRPDWGGLEVDVDVAGTTSQTTLWLRPRTVITGQRRWTLPARTPAYRVP LPELPHGLRITDVSLAADCLQLSALLPEWRTELPLRYLESVITQLSQGALSFVWPPLR SGAD" gene complement(155496..157247) /gene="lpqB" /locus_tag="Rv3244c" CDS complement(155496..157247) /gene="lpqB" /locus_tag="Rv3244c" /function="UNKNOWN" /note="Rv3244c, (MTCY20B11.19c), len: 583 aa. Probable lpqB, conserved lipoprotein; contains appropriately placed lipoprotein signature (PS00013). Equivalent to Q9CCJ0|LPQB|ML0775 PUTATIVE LIPOPROTEIN from Mycobacterium leprae (589 aa), FASTA scores: opt: 3375, E(): 1.4e-186, (87.9% identity in 579 aa overlap). Also similar to various proteins (in particular transferases) e.g. Q9KYX0|SCE33.13c PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (615 aa), FASTA scores: opt: 228, E(): 1.3e-05, (25.5% identity in 624 aa overlap); O87992|BBLPS1.19c PUTATIVE GLUTAMINE AMIDOTRANSFERASE from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (628 aa), FASTA scores: opt: 162, E(): 0.079, (28.05% identity in 171 aa overlap); Q9L2F4|SC7A8.01 PUTATIVE SUGAR KINASE (FRAGMENT) from Streptomyces coelicolor (434 aa), FASTA scores: opt: 143, E(): 0.72, (27.65% identity in 293 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED LIPOPROTEIN LPQB" /protein_id="CAB08345.1" /db_xref="GI:2072711" /db_xref="UniProtKB/TrEMBL:O05889" /translation="MRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSP GMDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAE KVSVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSDGWRIDRLPNGVFLDWQQF QETYKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLL APPLRLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADI RGPYVINADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVT PVPGAFGRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHS LSRPSWSLDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSR DGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRT DAAHPVSYVNLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGW ADVPGLMVPGAAPVLPG" misc_feature complement(157200..157232) /gene="lpqB" /locus_tag="Rv3244c" /note="PS00013 Prokaryotic membrane lipoprotein lipid attachment site" gene complement(157247..158950) /gene="mtrB" /locus_tag="Rv3245c" CDS complement(157247..158950) /gene="mtrB" /locus_tag="Rv3245c" /EC_number="2.7.3.-" /function="SENSOR PART OF A TWO COMPONENT REGULATORY SYSTEM." /note="Rv3245c, (MTCY20B11.20c), len: 567 aa. mtrB, sensor-like histidine kinase (EC 2.7.3.-) (see citations below), equivalent to Q9CCJ1|MTRB OR ML0774 PUTATIVE TWO-COMPONENT SYSTEM SENSOR KINASE from Mycobacterium leprae (562 aa), FASTA scores: opt: 3208, E(): 7.4e-173, (88.7% identity in 566 aa overlap). Also similar to others e.g. Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE KINASE from Streptomyces coelicolor (688 aa), FASTA scores: opt: 1355, E(): 1.1e-68, (48.95% identity in 515 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: MTCY369.03, E(): 1.5e-22; MTCY20G9.16, E(): 1.9e-17. SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES." /codon_start=1 /transl_table=11 /product="TWO COMPONENT SENSORY TRANSDUCTION HISTIDINE KINASE MTRB" /protein_id="CAB08346.1" /db_xref="GI:2072712" /db_xref="GOA:Q50496" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR009082" /db_xref="UniProtKB/Swiss-Prot:Q50496" /translation="MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVA LTLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDS SLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKA GQAAYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATG GLVLLVLLAGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFN DMAESLSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSADLDPTLRR STELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAG IELLVDLPAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRD YGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWGEPGEG ACFRLTLPMVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPREHAEWS G" repeat_unit complement(158951..159003) /note="53 bp Mycobacterial Interspersed Repetitive Unit, Class II" gene complement(159000..159686) /gene="mtrA" /locus_tag="Rv3246c" CDS complement(159000..159686) /gene="mtrA" /locus_tag="Rv3246c" /function="TRANSCRIPTIONAL ACTIVATOR PART OF A TWO COMPONENT REGULATORY SYSTEM." /experiment="experimental evidence, no additional details recorded" /note="Rv3246c, (MTCY20B11.21c), len: 228 aa. mtrA, transcriptional activator, response regulator (see citations below), equivalent to Q9CCJ2|MTRA|ML0773 PUTATIVE TWO-COMPONENT RESPONSE REGULATOR from Mycobacterium leprae (228 aa), FASTA scores: opt: 1458, E(): 1.4e-85, (98.7% identity in 228 aa overlap). Also highly similar to others e.g. Q9F9J5|SCRA PUTATIVE RESPONSE REGULATOR from Streptomyces coelicolor (228 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9KYW8|SCE33.15c PUTATIVE TWO-COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (229 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9% identity in 227 aa overlap); Q9F868|REGX3 RESPONSE REGULATOR REGX3 from Mycobacterium smegmatis (228 aa), FASTA scores: opt: 730, E(): 2.3e-39, (50.90% identity in 222 aa overlap); etc. Relatives in Mycobacterium tuberculosis are: U01971|MTU01971_1; Q11156|RGX3_MYCTU; MTCY20G9.17, E(): 0; MTCY31.31c, E(): 3.4e-29; MTCY369.02, E(): 5.7e-28. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Experiments showed mtrA is differentially expressed in virulent and avirulent strains during growth in macrophages." /codon_start=1 /transl_table=11 /product="TWO COMPONENT SENSORY TRANSDUCTION TRANSCRIPTIONAL REGULATORY PROTEIN MTRA" /protein_id="CAB08347.1" /db_xref="GI:2072713" /db_xref="GOA:P0A5Z4" /db_xref="UniProtKB/Swiss-Prot:P0A5Z4" /translation="MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTA VRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDY IMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFD LLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTV RGVGYKAGPP" gene complement(159756..160400) /gene="tmk" /locus_tag="Rv3247c" CDS complement(159756..160400) /gene="tmk" /locus_tag="Rv3247c" /EC_number="2.7.4.9" /function="PHOSPHORYLATION OF DTMP TO FORM DTDP IN BOTH DE NOVO AND SALVAGE PATHWAYS OF DTTP SYNTHESIS [CATALYTIC ACTIVITY: ATP + THYMIDINE 5'-PHOSPHATE = ADP + THYMIDINE 5'-DIPHOSPHATE]." /note="Rv3247c, (MTCY20B11.22c), len: 214 aa. Probable tmk, thymidylate kinase (EC 2.7.4.9), equivalent to Q9CCJ3|TMK|ML0772 PUTATIVE THYMIDYLATE KINASE from Mycobacterium leprae (210 aa), FASTA scores: opt: 1023, E(): 4.8e-57, (77.3% identity in 207 aa overlap). Also similar to other thymidylate kinases e.g. Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from Caulobacter crescentus (208 aa), FASTA scores: opt: 179, E(): 0.0003, (31.3% identity in 214 aa overlap); Q9V1E9|KTHY_PYRAB|TMK|PAB0319 from Pyrococcus abyssi (205 aa), FASTA scores: opt: 176, E(): 0.00045, (29.1% identity in 189 aa overlap); etc. BELONGS TO THE THYMIDYLATE KINASE FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE THYMIDYLATE KINASE TMK (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)" /protein_id="CAB08348.1" /db_xref="GI:2072714" /db_xref="GOA:O05891" /db_xref="InterPro:IPR000062" /db_xref="UniProtKB/Swiss-Prot:O05891" /translation="MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVA ADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAA YSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGR ARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS" gene complement(160497..161984) /gene="sahH" /locus_tag="Rv3248c" CDS complement(160497..161984) /gene="sahH" /locus_tag="Rv3248c" /EC_number="3.3.1.1" /function="THIOESTER HYDROLASE WHICH ACTING ON ETHER BOUNDS. COULD BE INVOLVED IN METHIONINE AND SELENOAMINO ACID METABOLISMS. ALSO INVOLVED IN ACTIVATED METHYL. CYCLE ADENOSYLHOMOCYSTEINE IS A COMPETITIVE INHIBITOR OF S-ADENOSYL-L-METHIONINE-DEPENDENT METHYL TRANSFERASE REACTIONS; THEREFORE ADENOSYLHOMOCYSTEINASE MAY PLAY A KEY ROLE IN THE CONTROL OF METHYLATIONS VIA REGULATION OF THE INTRACELLULAR CONCENTRATION OF ADENOSYLHOMOCYSTEINE [CATALYTIC ACTIVITY: S-ADENOSYL-L-HOMOCYSTEINE + H(2)O = ADENOSINE + L-HOMOCYSTEINE]." /experiment="experimental evidence, no additional details recorded" /note="Rv3248c, (MTCY20B11.23c), len: 495 aa. Probable sahH, adenosylhomocysteinase (EC 3.3.1.1), equivalent to Q9CCJ4|SAHH|ML0771 PUTATIVE S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE from Mycobacterium leprae (492 aa), FASTA scores: opt: 3019, E(): 1.3e-177, (91.4% identity in 489 aa overlap). Also highly similar to other adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces coelicolor (485 aa), FASTA scores: opt: 2258, E(): 5.7e-131, (70.0% identity in 483 aa overlap); P51540|SAHH_TRIVA from Trichomonas vaginalis (486 aa), FASTA scores: opt: 2005, E(): 1.8e-115, (62.05% identity in 477 aa overlap); P35007|SAHH_CATRO from Catharanthus roseus (Rosy periwinkle) (Madagascar periwinkle) (485 aa), FASTA scores: opt: 1941, E(): 1.5e-111, (60.15% identity in 492 aa overlap); etc. Has S-adenosyl-L-homocysteine hydrolase signature (PS00739). BELONGS TO THE ADENOSYLHOMOCYSTEINASE FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE ADENOSYLHOMOCYSTEINASE SAHH (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE)" /protein_id="CAB08349.1" /db_xref="GI:2072715" /db_xref="GOA:P60176" /db_xref="UniProtKB/Swiss-Prot:P60176" /translation="MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMP GLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHA AAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDA TMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEE TTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGK KVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIV VTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTF GDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLP KHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY" misc_feature complement(161118..161162) /gene="sahH" /locus_tag="Rv3248c" /note="PS00739 S-adenosyl-L-homocysteine hydrolase signature" gene complement(162089..162724) /locus_tag="Rv3249c" CDS complement(162089..162724) /locus_tag="Rv3249c" /function="PROBABLY INVOLVED IN A TRANSCRIPTIONAL MECHANISM" /experiment="experimental evidence, no additional details recorded" /note="Rv3249c, (MTCY20B11.24c), len: 211 aa. Possible transcriptional regulatory protein, tetR family, with similarity to several e.g. Q9AE61|ALKB1 PUTATIVE TETR-REGULATORY from Rhodococcus erythropolis (208 aa), FASTA scores: opt: 503, E(): 7.7e-26, (40.6% identity in 192 aa overlap); CAC37620 PUTATIVE TETR-REGULATORY PROTEIN from Prauserella rugosa (212 aa), FASTA scores: opt: 246, E(): 4.4e-09, (27.95% identity in 186 aa overlap); Q9K4B0|SC7E4.06 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL from Streptomyces coelicolor (203 aa), FASTA scores: opt: 224, E(): 1.1e-07, (34.5% identity in 197 aa overlap); Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.27 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 191, E(): 1.6e-05, (28.35% identity in 180 aa overlap); etc. Equivalent to AAK47689 from Mycobacterium tuberculosis strain CDC1551 (230 aa) but shorter 19 aa. COULD BELONG TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Possible helix-turn helix motif at aa 44-65 (+6.66 SD)." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)" /protein_id="CAB08350.1" /db_xref="GI:2072716" /db_xref="GOA:O05892" /db_xref="InterPro:IPR001647" /db_xref="UniProtKB/TrEMBL:O05892" /translation="MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAI TLSDVARAAGISRQTIYNEFGSRQGLAQGYALRLADRLVDNVHASLDANVGNFYEAFL QGFRSFFAESAADPLVISLLTGVAKPDLLQLITTDSAPIITRASARLAPAFTDTWVAT TDNDANVLSRAIVRLCLSYVSMPPEADHDVAADLARLITPFAERHGVINVP" gene complement(162721..162903) /gene="rubB" /locus_tag="Rv3250c" CDS complement(162721..162903) /gene="rubB" /locus_tag="Rv3250c" /function="INVOLVED IN THE HYDROCARBON HYDROXYLATING SYSTEM TO CONVERT CONVERSION OF DODECANE TO LAURIC ACID, WHICH TRANSFERS ELECTRONS FROM NADH TO RUBREDOXIN REDUCTASE AND THEN THROUGH RUBREDOXIN TO ALKANE 1 MONOOXYGENASE." /experiment="experimental evidence, no additional details recorded" /note="Rv3250c, (MTCY20B11.25c), len: 60 aa. Probable rubB, rubredoxin, highly similar to other rubredoxins e.g. Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA scores: opt: 391, E(): 2.2e-21, (83.05% identity in 59 aa overlap); Q9AE63|RUBA2 from Rhodococcus erythropolis (63 aa), FASTA scores: opt: 380, E(): 1.4e-20, (83.9% identity in 56 aa overlap); P42453|RUBR_ACICA|RUBA from Acinetobacter calcoaceticus (54 aa), FASTA scores: opt: 315, E(): 4.9e-16, (69.8% identity in 53 aa overlap); Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa), FASTA scores: opt: 298, E(): 8e-15, (64.15% identity in 53 aa overlap); Q9PGC3|XF0379 from Xylella fastidiosa (57 aa), FASTA scores: opt: 263, E(): 2.5e-12, (59.25% identity in 54 aa overlap); etc. Also similar to neighbouring ORF M. tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE RUBREDOXIN RUBB" /protein_id="CAB08351.1" /db_xref="GI:2072717" /db_xref="GOA:O05893" /db_xref="InterPro:IPR001052" /db_xref="InterPro:IPR004039" /db_xref="UniProtKB/TrEMBL:O05893" /translation="MNDYKLFRCIQCGFEYDEALGWPEDGIAAGTRWDDIPDDWSCPD CGAAKSDFEMVEVARS" misc_feature complement(162766..162798) /gene="rubB" /locus_tag="Rv3250c" /note="PS00202 Rubredoxin signature" gene complement(162908..163075) /gene="rubA" /locus_tag="Rv3251c" CDS complement(162908..163075) /gene="rubA" /locus_tag="Rv3251c" /function="INVOLVED IN THE HYDROCARBON HYDROXYLATING SYSTEM, WHICH TRANSFERS ELECTRONS FROM NADH TO RUBREDOXIN REDUCTASE AND THEN THROUGH RUBREDOXIN TO ALKANE 1 MONOOXYGENASE." /experiment="experimental evidence, no additional details recorded" /note="Rv3251c, (MTCY20B11.26c), len: 55 aa. Probable rubA, rubredoxin, highly similar to other rubredoxins (but sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus erythropolis (61 aa), FASTA scores: opt: 335, E(): 1e-17, (73.6% identity in 53 aa overlap); P00272|RUB2_PSEOL|ALKG from Pseudomonas oleovorans (172 aa), FASTA scores: opt: 278, E(): 2.7e-13, (65.3% identity in 49 aa overlap); CAC38028|ALKG from Alcanivorax borkumensis (174 aa), FASTA scores: opt: 271, E(): 8.6e-13, (62.0% identity in 50 aa overlap); Q9WWW4|ALKG from Pseudomonas putida (175 aa), FASTA scores: opt: 270, E(): 1e-12, (61.8% identity in 55 aa overlap); etc. Also highly similar to C-terminus of Q9XBM1|ALKB ALKANE 1-MONOOXYGENASE (EC 1.14.15.3) from Prauserella rugosa (490 aa), FASTA scores: opt: 296, E(): 2.9e-14, (75.5% identity in 49 aa overlap). Also similar to neighbouring ORF Mycobacterium tuberculosis rubB (MTCY20B11.25c). Contains rubredoxin signature (PS00202). BELONGS TO THE RUBREDOXIN FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE RUBREDOXIN RUBA" /protein_id="CAB08322.1" /db_xref="GI:2072718" /db_xref="GOA:O05894" /db_xref="InterPro:IPR001052" /db_xref="InterPro:IPR004039" /db_xref="UniProtKB/TrEMBL:O05894" /translation="MAAYRCPVCDYVYDEANGDAREGFPAGTGWDQIPDDWCCPDCAV REKVDFEKIGG" misc_feature complement(162947..162979) /gene="rubA" /locus_tag="Rv3251c" /note="PS00202 Rubredoxin signature" gene complement(163075..164325) /gene="alkB" /locus_tag="Rv3252c" CDS complement(163075..164325) /gene="alkB" /locus_tag="Rv3252c" /EC_number="1.14.15.3" /function="THOUGHT TO BE INVOLVED IN FATTY ACID METABOLISM. GENERATES OCTANOL AND OXIDIZED RUBREDOXIN FROM OCTANE AND REDUCED RUBREDOXIN. ALSO HYDROXYLATES FATTY ACIDS IN THE OMEGA-POSITION [CATALYTIC ACTIVITY: OCTANE + REDUCED RUBREDOXIN + (O)2 = 1-OCTANOL + OXIDIZED RUBREDOXIN + H(2)O]." /experiment="experimental evidence, no additional details recorded" /note="Rv3252c, (MTCY20B11.27c), len: 416 aa. Probable alkB, transmembrane alkane-1-monooxygenase (EC 1.14.15.3), highly similar to many (see Marin et al., 2001) e.g. Q9AE68|ALKB2 from Rhodococcus erythropolis (408 aa), FASTA scores: opt: 2018, E(): 9.6e-122, (68.6% identity in 415 aa overlap); Q9AFD5|ALKB from Nocardioides sp. CF8 (483 aa), FASTA scores: opt: 1485, E(): 1.4e-87, (56.55% identity in 405 aa overlap); Q9XAU0|ALKB1 from Rhodococcus erythropolis (391 aa), FASTA scores: opt: 1400, E(): 3.3e-82, (62.6% identity in 396 aa overlap); Q9XBM1|ALKB from Prauserella rugosa (490 aa), FASTA scores: opt: 1266, E(): 1.5e-73, (57.55% identity in 410 aa overlap); CAC40954|ALKB4 from Rhodococcus erythropolis (386 aa), FASTA scores: opt: 1190, E(): 9.1e-69, (54.3% identity in 383 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN)" /protein_id="CAB08323.1" /db_xref="GI:2072719" /db_xref="GOA:O05895" /db_xref="InterPro:IPR005804" /db_xref="UniProtKB/TrEMBL:O05895" /translation="MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLP LIWGMNQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDKYYR YCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSVGVLGGVGINTA HEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRVSTPEDPASARFGETLWEFL PRSVIGGLRSAVHLEAQRLRRLGVSPWNPMTYLRNDVLNAWLMSVVLWGGLIAVFGPA LIPFVIIQAVFGFSLLEAVNYLEHYGLLRQKSANGRYERCAPVHSWNSDHIVTNLFLY HLQRHSDHHANPTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYG GDITRVNLHPRVREKALARYGASA" gene complement(164434..165921) /locus_tag="Rv3253c" CDS complement(164434..165921) /locus_tag="Rv3253c" /function="THOUGHT TO BE INVOLVED IN CATIONIC AMINO ACID TRANSPORT ACROSS THE MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." /note="Rv3253c, (MTCY20B11.28c), len: 495 aa. Possible cationic amino acid transporter, integral membrane protein, similar to many e.g. O69844|SC1C3.02 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Streptomyces coelicolor (503 aa), FASTA scores: opt: 1649, E(): 5.8e-92, (52.6% identity in 485 aa overlap); Q9AE69 PUTATIVE TRANSPORTER (FRAGMENT) from Rhodococcus erythropolis (385 aa), FASTA scores: opt: 1594, E(): 9.7e-89, (62.0% identity in 387 aa overlap); Q9PBD7|XF2207 CATIONIC AMINO ACID TRANSPORTER from Xylella fastidiosa (483 aa), FASTA scores: opt: 1079, E(): 1.2e-57, (40.55% identity in 493 aa overlap); Q9SRU9|F20H23.25 PUTATIVE CATIONIC AMINO ACID TRANSPORTER from Arabidopsis thaliana (Mouse-ear cress) (614 aa), FASTA scores: opt: 802, E(): 6.7e-41, (36.4% identity in 445 aa overlap); P30823|CTR1_RAT|SLC7A1|ATRC1 HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 from Rattus norvegicus (Rat) (624 aa), FASTA scores: opt: 782, E(): 1.1e-39, (36.1% identity in 432 aa overlap); etc. Relatives in Mycobacterium tuberculosis include: MTCY3G12.14, E(): 5.6e-31; MTCY39.19, E(): 1.6e-14. SEEMS TO BELONG TO THE APC FAMILY." /codon_start=1 /transl_table=11 /product="POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE PROTEIN" /protein_id="CAB08324.1" /db_xref="GI:2072720" /db_xref="GOA:O05896" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="UniProtKB/TrEMBL:O05896" /translation="MAGRRRMKSVEQSIADTDEPTTRLRKDLTWWDLVVFGVSVVIGA GIFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVAGSAYTFSYATFG EFLAWVIGWNLVLELAMGAAVVAKGWSSYLGTVFGFGNGTGHLGSLQLDWGALVIVTL VATLIALGTKLSSRFSAVVTAIKVSVVVLVVVVGAFYIRAANYSPFIPEPEVQHHGGG LDQSVFSLLTGAQGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGIL ASLGVVTLLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGAL AGLTTVVMVLMLGQCRVLFAMARDGLVPRQLAKTGSRGTPVRVTVLVAVLVATTASVF PITKLEEMVNVGTLFAFILVSAGVVVLRRTRPDLQRGFTAPWVPLLPIAAVCACLWLM LNLTALTWIRFGIWLVAGTAIYVGYGRRHSAQGLRQARESATRRC" gene 166012..167400 /locus_tag="Rv3254" CDS 166012..167400 /locus_tag="Rv3254" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3254, (MTCY20B11.29), len: 462 aa. Conserved hypothetical protein, similar to CAC37877|SC1G7.02 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (440 aa), FASTA scores: opt: 606, E(): 6.2e-31, (31.7% identity in 445 aa overlap); O86550|SC1F2.13c HYPOTHETICAL 50.7 KDA PROTEIN from Streptomyces coelicolor (476 aa), FASTA scores: opt: 577, E(): 4.5e-29, (32.5% identity in 400 aa overlap); Q9L0A8|SCC24.09 PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (468 aa), FASTA scores: opt: 380, E(): 1.3e-16, (30.7% identity in 391 aa overlap); BAB48792|MLL1411 PROBABLE FAD-DEPENDENT MONOOXYGENASE from Rhizobium loti (Mesorhizobium loti) (421 aa), FASTA scores: opt: 128, E(): 1.1, (25.2% identity in 397 aa overlap); Q9L7X9|BENF BENZOATE-SPECIFIC PORIN-LIKE PROTEIN from Pseudomonas putida (397 aa), FASTA scores: opt: 119, E(): 4, (24.85% identity in 157 aa overlap); etc. Also similar to N-terminus of AAK46259|MT1987 PUTATIVE FERREDOXIN REDUCTASE, ELECTRON TRANSFER COMPONENT from Mycobacterium tuberculosis strain CDC1551 (839 aa), FASTA scores: opt: 493, E(): 1.5e-23, (30.65% identity in 382 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08325.1" /db_xref="GI:2072721" /db_xref="UniProtKB/TrEMBL:O05897" /translation="MVIGASIAGLCAARVLSDFYSTVTVFERDELPEAPANRATVPQD RHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENRPDCIYLGAAGHVLGTGHTLRKE FTAYVPSRPHLEWQLRRRVLQLSNVQIVRRLVTEPQFERRQQRVVGVLLDSPGSGQDR EREEFIAADLVVDAAGRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAE KVVVAGASHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFTA ALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGMTMTSLQ AGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDISFHHATAEPLPRWWR PAGSLFDQFLGAAETDPVLAEWFLRRFSLLDSLYMVPSVPIIGRAIAHNLRLWLKEQR ERRQPVTTRRSP" gene complement(167378..168604) /gene="manA" /locus_tag="Rv3255c" CDS complement(167378..168604) /gene="manA" /locus_tag="Rv3255c" /EC_number="5.3.1.8" /function="THIS ENZYME CONVERTS D-MANNOSE 6-PHOSPHATE TO D-FRUCTOSE 6-PHOSPHATE [CATALYTIC ACTIVITY: D-MANNOSE 6-PHOSPHATE = D-FRUCTOSE 6-PHOSPHATE]." /note="Rv3255c, (MTCY20B11.30c), len: 408 aa. Probable manA, mannose-6-phosphate isomerase (EC 5.3.1.8), equivalent to Q9CCJ5|MANA|ML0765 PUTATIVE MANNOSE-6-PHOSPHATE ISOMERASE from Mycobacterium leprae (410 aa), FASTA scores: opt: 2271, E(): 1.6e-133, (84.45% identity in 411 aa overlap). Also similar to many others e.g. Q9KZL9|MANA from Streptomyces coelicolor (383 aa), FASTA scores: opt: 946, E(): 2.4e-51, (44.4% identity in 403 aa overlap); Q9KV87|VC0269 from Vibrio cholerae (399 aa), FASTA scores: opt: 726, E(): 1.1e-37, (34.15% identity in 404 aa overlap); Q9CMJ5|PMI|PM0829 from Pasteurella multocida (400 aa), FASTA scores: opt: 640, E(): 2.4e-32, (32.5% identity in 391 aa overlap); etc. SIMILAR TO FAMILY 1 OF MANNOSE-6-PHOSPHATE ISOMERASES." /codon_start=1 /transl_table=11 /product="PROBABLE MANNOSE-6-PHOSPHATE ISOMERASE MANA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE)" /protein_id="CAB08326.1" /db_xref="GI:2072722" /db_xref="GOA:O05898" /db_xref="InterPro:IPR001250" /db_xref="UniProtKB/TrEMBL:O05898" /translation="MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGD PAWLQTPHGQTSLLEALVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSA EQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRA LAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATE FGAEAKTVLELGERYPGDAGVLAALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMA NSDNVLRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLGLVFETPTDEFAATL LVLDGDHLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIR LTAGQPAKLFRATVGL" gene complement(168612..169652) /locus_tag="Rv3256c" CDS complement(168612..169652) /locus_tag="Rv3256c" /function="UNKNOWN" /note="Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa. Conserved hypothetical protein, equivalent to Q9CCJ6|ML0764 HYPOTHETICAL PROTEIN from Mycobacterium leprae (365 aa), FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012, (31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap). TBparse score is 0.878." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB08352.1" /db_xref="GI:3261743" /db_xref="UniProtKB/TrEMBL:O05899" /translation="MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEG ELDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVL IVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFG LSRYLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGC QLALAGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEID GPAPQRLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRL EMAAVYLRLVRG" gene complement(169649..171046) /gene="pmmA" /locus_tag="Rv3257c" CDS complement(169649..171046) /gene="pmmA" /locus_tag="Rv3257c" /EC_number="5.4.2.8" /function="THIS ENZYME CONVERSES D-MANNOSE 1-PHOSPHATE IN D-MANNOSE 6-PHOSPHATE [CATALYTIC ACTIVITY: D-MANNOSE 1-PHOSPHATE = D-MANNOSE 6-PHOSPHATE]." /note="Rv3257c, (MTV015.02c), len: 465 aa. Probable pmmA, phosphomannomutase (EC 5.4.2.8), equivalent to Q9CCJ7|PMMA|ML0763 PHOSPHOMANNOMUTASE from Mycobacterium leprae (468 aa), FASTA scores: opt: 2533, E(): 2e-145, (83.1% identity in 468 aa overlap). Also similar to many e.g. Q9KZL6|MANB from Streptomyces coelicolor (454 aa), FASTA scores: opt: 1820, E(): 2e-102, (63.2% identity in 459 aa overlap); Q9PGN8|XF0260 from Xylella fastidiosa (500 aa), FASTA scores: opt: 1085, E(): 4.7e-58, (40.7% identity in 462 aa overlap); Q9EY19|MANB from Salmonella enterica subsp. arizonae (456 aa), FASTA scores: opt: 988, E(): 3.1e-52, (38.65% identity in 445 aa overlap); etc. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. TBparse score is 0.903." /codon_start=1 /transl_table=11 /product="PROBABLE PHOSPHOMANNOMUTASE PMMA (PMM) (PHOSPHOMANNOSE MUTASE)" /protein_id="CAB08353.1" /db_xref="GI:3261744" /db_xref="GOA:O86374" /db_xref="InterPro:IPR002110" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="UniProtKB/TrEMBL:O86374" /translation="MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRTE DARPVVIGHDMRDSSPSLADAFAAGVTGQGLDVVRVGLASTDQLYFASGLLDCPGAMF TASHNPAAYNGIKMCRAAAKPVGADTGLTAIRDDLIAGVARYDGTPGTIADQDVLVDY GAFLRSLVDTSGLRPLRVAVDAGNGMAGHTAPAVLGVIDSITLLPSYFELDGSFPNHE ANPLDPANLVDLQAYVRDTGADIGLAFDGDADRCFVVDERGQPVSPSTVTALVAAREL NREIGATIIHNVITSRAVPELVAERGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHY YFRDFWGADSGMLAALHVLAALGEQSRPLSELTADYQRYESSGEINFTVVDSSACVEA VLKSFGNRIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVEGRSVGDVDAVVRQV SAEIAAQSAHAKAGP" gene complement(171148..171639) /locus_tag="Rv3258c" CDS complement(171148..171639) /locus_tag="Rv3258c" /function="UNKNOWN" /note="Rv3258c, (MTV015.03c), len: 163 aa. Conserved hypothetical protein, equivalent to Q9CCJ8|ML0762 HYPOTHETICAL PROTEIN from Mycobacterium leprae (165 aa), FASTA scores: opt: 840, E(): 9.9e-42, (76.9% identity in 169 aa overlap). Also similar to Q9KZL4|SCE34.11c HYPOTHETICAL 15.0 KDA PROTEIN from Streptomyces coelicolor (140 aa), FASTA scores: opt: 353, E(): 1.1e-13, (48.3% identity in 147 aa overlap); and shows really weak similarity to other bacterial proteins. TBparse score is 0.928." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17072.1" /db_xref="GI:2894206" /db_xref="UniProtKB/TrEMBL:O53351" /translation="MRVSGASAALVHDSLSVVNVPRRCCRPGCPHYAVATLTFVYSDS TAVIGPLATAREPHSWDLCVGHAGRITAPRGWELVRHAGPLPSHPDEDDLVALADAVR EGGPSAGRRHHPGGNGAPLHGFDDFPAAATGAPTGGGVLAPPEPGAGRRRGHLRVLPD PAD" gene 171762..172181 /locus_tag="Rv3259" CDS 171762..172181 /locus_tag="Rv3259" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3259, (MTV015.04), len: 139 aa. Conserved hypothetical protein, equivalent, but shorter 29 aa, to Q9CCJ9|ML0761 HYPOTHETICAL PROTEIN from Mycobacterium leprae (167 aa), FASTA scores: opt: 846, E(): 2.2e-47, (89.2% identity in 139 aa overlap). C-terminus highly similar to Q9S425 HYPOTHETICAL 6.0 KDA PROTEIN (FRAGMENT) from Mycobacterium smegmatis (54 aa), FASTA scores: opt: 275, E(): 2.7e-11, (81.15% identity in 53 aa overlap). Also similar to Q9KZL3|SCE34.12 from Streptomyces coelicolor (117 aa), FASTA scores: opt: 152, E(): 0.004, (34.15% identity in 126 aa overlap). Equivalent to AAK47699 from Mycobacterium tuberculosis strain CDC1551 (175 aa) but shorter 36 aa. TBparse score is 0.884." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17073.1" /db_xref="GI:2894207" /db_xref="UniProtKB/TrEMBL:O53352" /translation="MRGPLLPPTVPGWRSRAERFDMAVLEAYEPIERRWQERVSQLDI AVDEIPRIAAKDPESVQWPPEVIADGPIALARLIPAGVDVRGNATRARIVLFRKPIER RAKDTEELGELLHEILVAQVAIYLDVDPSVIDPTIDD" gene complement(172209..172478) /gene="whiB2" /locus_tag="Rv3260c" CDS complement(172209..172478) /gene="whiB2" /locus_tag="Rv3260c" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /standard_name="whmD" /experiment="experimental evidence, no additional details recorded" /note="Rv3260c, (MTV015.05c), len: 89 aa. Probable whiB2 (alternate gene name: whmD), WhiB-like regulatory protein (see Hutter & Dick 1999), similar to WhiB paralogue of Streptomyces coelicolor, wblE gene product (85 aa). Equivalent to Q9CCK0|WHIB2|ML0760 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (89 aa), FASTA scores: opt: 550, E(): 6.1e-31, (85.4% identity in 89 aa overlap). Also similar to others e.g. Q9S426 WHMD REGULATORY PROTEIN (see Gomez & Bishai 2000) from Mycobacterium smegmatis (129 aa), FASTA scores: opt: 488, E(): 1.4e-26, (83.55% identity in 85 aa overlap); Q06387|WHIB-STV WHIB-STV PROTEIN from Streptomyces griseocarneus (87 aa), FASTA scores: opt: 443, E(): 1.2e-23, (74.7% identity in 83 aa overlap); Q05429|WHIB|WHIB1 TRANSCRIPTION-LIKE FACTOR WHIB from Streptomyces aureofaciens (87 aa), FASTA scores: opt: 442, E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc. Equivalent to AAK47700 WhiB-related protein from Mycobacterium tuberculosis strain CDC1551 (123 aa) but shorter 34 aa. Also similar to other Mycobacterium tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71 aa overlap) and MTCY78.13c (37.4% identity in 91 aa overlap). Start chosen by homology but ORF continues to ATG upstream at 3754." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB2" /protein_id="CAA17074.1" /db_xref="GI:2894208" /db_xref="GOA:O53353" /db_xref="InterPro:IPR003482" /db_xref="UniProtKB/TrEMBL:O53353" /translation="MVPEAPAPFEEPLPPEATDQWQDRALCAQTDPEAFFPEKGGSTR EAKKICMGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGII" gene 172880..173875 /gene="fbiA" /locus_tag="Rv3261" CDS 172880..173875 /gene="fbiA" /locus_tag="Rv3261" /function="REQUIRED FOR COENZYME F420 PRODUCTION: INVOLVED IN THE CONVERSION OF FO INTO F420." /note="Rv3261, (MTCY71.01), len: 331 aa. Probable fbiA, F420 biosynthesis protein, equivalent to FBIA F420 biosynthesis protein fbiA from Mycobacterium bovis BCG (see citations below). Also equivalent, but shorter 46 aa, to Q9CCK1|ML0759 HYPOTHETICAL PROTEIN from Mycobacterium leprae (379 aa), FASTA scores: opt: 1855, E(): 3.9e-110, (79.3% identity in 333 aa overlap). Also similar to others e.g. Q9KZK9|SCE34.17 HYPOTHETICAL 33.6 KDA PROTEIN from Streptomyces coelicolor (319 aa), FASTA scores: opt: 1151, E(): 1.2e-65, (55.1% identity in 332 aa overlap); O29345|AF0917 CONSERVED HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (296 aa), FASTA scores: opt: 469, E(): 1.7e-22, (31.15% identity in 302 aa overlap); Q58653|MJ1256 HYPOTHETICAL PROTEIN from Methanococcus jannaschii (311 aa), FASTA scores: opt: 436, E(): 2.2e-20, (27.35% identity in 274 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE F420 BIOSYNTHESIS PROTEIN FBIA" /protein_id="CAB07094.1" /db_xref="GI:1877316" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010115" /db_xref="UniProtKB/TrEMBL:P96866" /translation="MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAV VNVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWF ELGDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPV DESRKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVV SIGAILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHY GARCATGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA" gene 173872..175218 /gene="fbiB" /locus_tag="Rv3262" CDS 173872..175218 /gene="fbiB" /locus_tag="Rv3262" /function="REQUIRED FOR COENZYME F420 PRODUCTION: INVOLVED IN THE CONVERSION OF FO INTO F420." /note="Rv3262, (MTCY71.02), len: 448 aa. Probable fbiB, F420 biosynthesis protein, equivalent to FBIB F420 biosynthesis protein fbiB from Mycobacterium bovis BCG (see citations below). Also equivalent to Q9CCK2|ML0758 PUTATIVE OXIDOREDUCTASE from Mycobacterium leprae (457 aa), FASTA scores: opt: 2411, E(): 3.5e-137, (82.25% identity in 445 aa overlap). Also similar to Q9KZK8|SCE34.18 PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (443 aa), FASTA scores: opt: 1180, E(): 2.2e-63, (51.75% identity in 433 aa overlap); other oxidoreductases in C-terminus; and several hypothetical bacterial proteins." /codon_start=1 /transl_table=11 /product="PROBABLE F420 BIOSYNTHESIS PROTEIN FBIB" /protein_id="CAB07089.1" /db_xref="GI:1877317" /db_xref="GOA:P96867" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR002847" /db_xref="InterPro:IPR008225" /db_xref="UniProtKB/TrEMBL:P96867" /translation="MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGD VVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLGLV QAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITDTMGRAWRNGQ TDAAVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAAAADLVKGKLTATPVAVVR GFGVSDDGSTARQLLRPGANDLFWLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLV EAAVAEALTAPAPHHTRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERR VARGQILYDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRG LGSCWIGSTIFAADLVRDELDLPVDWEPLGAIAIGYADEPSGLRDPVPAADLLILK" gene 175514..177175 /locus_tag="Rv3263" CDS 175514..177175 /locus_tag="Rv3263" /EC_number="2.1.1.-" /function="CAUSES DNA METHYLATION." /note="Rv3263, (MTCY71.03), len: 553 aa. Probable DNA methylase (EC 2.1.1.-), equivalent to Q9CCK4|ML0756 PROBABLE DNA METHYLASE from Mycobacterium leprae (555 aa), FASTA scores: opt: 2980, E(): 2.1e-184, (81.9% identity in 541 aa overlap). Also similar to others e.g. P25240|MT57_ECOLI|ECO57IM MODIFICATION METHYLASE from Escherichia coli (544 aa), FASTA scores: opt: 595, E(): 1e-30, (30.35% identity in 507 aa overlap); P25201|MTA1_ACICA|ACCIM MODIFICATION METHYLASE ACCI from Acinetobacter calcoaceticus (540 aa), FASTA scores: opt: 366, E(): 5.7e-16, (23.35% identity in 467 aa overlap); Q56752|M-ACCI ACCI METHYLASE from Bergeyella zoohelcum (541 aa), FASTA scores: opt: 365, E(): 6.6e-16, (22.95% identity in 466 aa overlap); etc. Contains PS00092 N-6 Adenine-specific DNA methylases signature. Alternative start site at aa 25." /codon_start=1 /transl_table=11 /product="PROBABLE DNA METHYLASE (MODIFICATION METHYLASE) (METHYLTRANSFERASE)" /protein_id="CAB07090.1" /db_xref="GI:1877318" /db_xref="GOA:P96868" /db_xref="InterPro:IPR002052" /db_xref="UniProtKB/TrEMBL:P96868" /translation="MQPSHPTRPGAVIRYVGSSLDTCPMTTFAGKTAASADKVRGGYY TPPAVARFLAHWVHQAGPKILEPSCGDGRILRELSAITDHAHGVELVAREAKKSRDFA SVDTENLFTWLHKTQLGSWDGVAGNPPYIRFGNWASEQRDPALELMRRVGLRPTKLTN AWVPFVVASTTLARDGGRVGLVVPAELLQVTYAAQLREFLLSRYREITLVTFERLVFD GILQEVVLFCGVVGPGPAHIRTVRLGDANDLNALGDKDFTNESAPALLHEKEKWTKYF LDPAQIRLLRGLKQSATMIRLGELADVDVGIVTGRNSFFTFTDAKAQALGLRAHCVPL VSRSAQLSGLIYDEDCRACDVAGNHRTWLLDAADYPTDPALVAHITAGEAAGVHLGYK CSIRKPWWSTPSLWMPDLFMLRQIHFAPRLTVNAAAATSTDTVHRVRLDPNVDPATLA AVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPMPPPAYGSAELAQDVDLLLKANE IDKALDVVDRHVLIDGLGLSPRLVAGCRAAWLTLRDRRTKRGSRR" misc_feature 175883..175903 /locus_tag="Rv3263" /note="PS00092 N-6 Adenine-specific DNA methylases signature" gene complement(177235..178314) /gene="manB" /locus_tag="Rv3264c" CDS complement(177235..178314) /gene="manB" /locus_tag="Rv3264c" /EC_number="2.7.7.-" /function="INVOLVED IN GDP-MANNOSE BIOSYNTHESIS AND BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE (D-ALPHA-D PATHWAY): GENERATES GDP-MANNOSE AND PHOSPHATE FROM GTP AND ALPHA-D-MANNOSE 1-PHOSPHATE. MANB PRODUCT IS NEEDED FOR ALL MANNOSYL GLYCOLIPIDS AND POLYSACCHARIDES WHICH, LIKE RHAMNOSYL RESIDUES, ARE AN IMPORTANT PART OF THE MYCOBACTERIUM ENVELOPE [CATALYTIC ACTIVITY: ALPHA-D-MANNOSE 1-PHOSPHATE + GTP = GDP-MANNOSE + PHOSPHATE]." /standard_name="hddC" /experiment="experimental evidence, no additional details recorded" /note="Rv3264c, (MTCY71.04c), len: 359 aa. manB (alternate gene name: hddC), D-alpha-D-mannose-1-phosphate guanylyltransferase (EC 2.7.7.-) (see citations below), equivalent to Q9CCK6|RMLA2|ML0753 PUTATIVE SUGAR-PHOSPHATE NUCLEOTIDYL TRANSFERASE from Mycobacterium leprae (358 aa), FASTA scores: opt: 2075, E(): 2.7e-115, (86.9% identity in 359 aa overlap). Also similar to others e.g. Q9KZK6|SCE34.20c PUTATIVE NUCLEOTIDE PHOSPHORYLASE from Streptomyces coelicolor (360 aa), FASTA scores: opt: 1314, E(): 2.2e-70, (57.0% identity in 358 aa overlap); Q9KZP4|SC1A8A.08 PUTATIVE MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Streptomyces coelicolor (831 aa), FASTA scores: opt: 699, E(): 8.6e-34, (34.45% identity in 354 aa overlap) (only similarity in N-terminus for this one); P74589|SLL1496 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Synechocystis sp. strain PCC 6803 (843 aa), FASTA scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa overlap) (only similarity in N-terminus for this one too); BAB59222|TVG0079558 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE from Thermoplasma volcanium (359 aa), FASTA scores: opt: 664, E(): 5.2e-32, (34.6% identity in 338 aa overlap); Q9ZTW5|GMP GDP-MANNOSE PYROPHOSPHORYLASE from Solanum tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E(): 2.3e-30, (34.65% identity in 361 aa overlap); etc. BELONGS TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that previously known as rmlA2." /codon_start=1 /transl_table=11 /product="D-ALPHA-D-MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE MANB (D-ALPHA-D-HEPTOSE-1-PHOSPHATE GUANYLYLTRANSFERASE)" /protein_id="CAE55575.1" /db_xref="GI:38490346" /db_xref="GOA:Q7D5T3" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="UniProtKB/TrEMBL:Q7D5T3" /translation="MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLS RIAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLR NDTAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAF LEKTEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDAS YWRDMGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRG AEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVIGDGADIGARC ELLSGARVWPGVFLPDGGIRYSSDV" gene complement(178316..179221) /gene="wbbL1" /locus_tag="Rv3265c" CDS complement(178316..179221) /gene="wbbL1" /locus_tag="Rv3265c" /EC_number="2.-.-.-" /function="PROBABLY INVOLVED IN CELL WALL ARABINOGALACTAN LINKER FORMATION: USES DTDP-L-RHAMNOSE AS SUBSTRATE TO INSERT THE RHAMNOSYL RESIDUE INTO THE CELL WALL. SEEMS TO BE ESSENTIAL FOR MYCOBACTERIAL VIABILITY." /standard_name="wbbL" /experiment="experimental evidence, no additional details recorded" /note="Rv3265c, (MTCY71.05c), len: 301 aa. Probable wbbL1, dTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL A-3-L-RHAMNOSYL TRANSFERASE (EC 2.-.-.-) (see citations below), equivalent to Q9CCK7|WBBL|ML0752 PUTATIVE DTDP-RHAMNOSYL TRANSFERASE from Mycobacterium leprae (308 aa), FASTA scores: opt: 1788, E(): 3e-104, (85.05% identity in 301 aa overlap); and Q9RN50|WBBL|Q9RN49 (see note * below) DTDP-RHA:A-D-GLCNAC-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE from Mycobacterium smegmatis (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86, (72.35% identity in 293 aa overlap). Note that previously known as wbbL. [* Note: UNPUBLISHED (experimental study on Mycobacterium smegmatis). Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases - The cell wall arabinogalactan linker formation enzyme, dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase is essential for mycobacterial viability - Mills J.A., Motichka K., Jucker M., Wu H.P., Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W., Pan F., Kimbrel S., Kundu M., McNeil M.]." /codon_start=1 /transl_table=11 /product="PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WBBL1 (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENY L)" /protein_id="CAE55576.1" /db_xref="GI:38490347" /db_xref="GOA:Q7D5T2" /db_xref="InterPro:IPR001173" /db_xref="UniProtKB/TrEMBL:Q7D5T2" /translation="MVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAA VQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGS IDALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTT AYRQERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWL SVYVPSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLAL RSHLMVRSSLRRSRRRKLKLVEGRH" gene complement(179232..180146) /gene="rmlD" /locus_tag="Rv3266c" CDS complement(179232..180146) /gene="rmlD" /locus_tag="Rv3266c" /EC_number="1.-.-.-" /function="INVOLVED IN dTDP-L-RHAMNOSE BIOSYNTHESIS: CONVERTS dTDP-6-DEOXY-L-LYXO-4-HEXULOSE TO dTDP-L-RHAMNOSE WITH THE CONCOMITANT OXIDATION OF NADPH TO NADP+ [CATALYTIC ACTIVITY: dTDP-6-DEOXY-L-LYXO-4-HEXULOSE + NADPH = dTDP-L-RHAMNOSE + NADP+]." /experiment="experimental evidence, no additional details recorded" /note="Rv3266c, (MTCY71.06c), len: 304 aa. rmlD, dTDP-6-deoxy-L-lyxo-4-hexulose reductase (dTDP-rhamnose modification protein) (EC 1.-.-.-)(see citations below), highly similar to Q9CCK8 putative dTDP-rhamnose modification protein from Mycobacterium leprae (311 aa), FASTA scores, opt: 1440, E(): 1.1e-78, (74.7% identity in 312 aa overlap); and similar to several dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) e.g. STRL_STRGR|P29781 from Streptomyces griseus (304 aa), FASTA scores, opt: 788, E(): 0, (47.4% identity in 304 aa overlap)." /codon_start=1 /transl_table=11 /product="dTDP-6-DEOXY-L-LYXO-4-HEXULOSE REDUCTASE RMLD (dTDP-RHAMNOSE MODIFICATION PROTEIN) (dTDP-RHAMNOSE BIOSYNTHESIS PROTEIN) (dTDP-RHAMNOSE SYNTHASE)" /protein_id="CAB07093.1" /db_xref="GI:1877321" /db_xref="GOA:P96871" /db_xref="InterPro:IPR005913" /db_xref="UniProtKB/TrEMBL:P96871" /translation="MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITD PAAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHV STDYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYT GGTGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAAN EGVVSRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLR HWRSALATALAAPANSTSIDRRLPSTRD" gene 180222..181718 /locus_tag="Rv3267" CDS 180222..181718 /locus_tag="Rv3267" /function="UNKNOWN" /note="Rv3267, (MTCY71.07), len: 498 aa. Conserved hypothetical protein, CPSA-related protein, equivalent to Q9CCK9|ML0750 HYPOTHETICAL PROTEIN from Mycobacterium leprae (489 aa), FASTA scores: opt: 2523, E(): 5e-138, (78.9% identity in 498 aa overlap); and Q50160|CPSA (HYPOTHETICAL PROTEIN CPSA) from Mycobacterium leprae (516 aa), FASTA scores: opt: 868, E(): 1.2e-42, (34.7% identity in 507 aa overlap). Also similar to O06347|CPSA|Rv3484|MTCY13E12.37 CPSA from Mycobacterium tuberculosis (512 aa), FASTA scores: opt: 928, E(): 4.2e-46, (37.35% identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c HYPOTHETICAL 72.9 KDA PROTEIN from Mycobacterium tuberculosis (684 aa), FASTA scores: opt: 434, E(): 1.5e-17, (30.9% identity in 541 aa overlap). Also similar to Q9KZK0|SCE34.26 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (507 aa), FASTA scores: opt: 437, E(): 8.1e-18, (28.55% identity in 469 aa overlap); O68907 FRNA PROTEIN from Streptomyces roseofulvus (770 aa), FASTA scores: opt: 388, E(): 7.6e-15, (32.6% identity in 267 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN (CPSA-RELATED PROTEIN)" /protein_id="CAB07086.1" /db_xref="GI:1877322" /db_xref="InterPro:IPR004474" /db_xref="UniProtKB/TrEMBL:P96872" /translation="MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIF HMSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILI RVPNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAA GTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGAD FPAGRQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLK RLEQAVQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVD PRQVQDWVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTT GSVGNNDGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYS GPGSGLGGSDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN" misc_feature 180588..180611 /locus_tag="Rv3267" /note="PS00017 ATP/GTP-binding site motif A" gene 181757..182446 /locus_tag="Rv3268" CDS 181757..182446 /locus_tag="Rv3268" /function="UNKNOWN" /note="Rv3268, (MTCY71.08), len: 229 aa. Conserved hypothetical protein, similar to Q9KZK4|SCE34.22 HYPOTHETICAL 27.1 KDA PROTEIN from Streptomyces coelicolor (263 aa), FASTA scores: opt: 442, E(): 5.9e-20, (40.1% identity in 242 aa overlap). Also weak similarity to N-terminal part (approximatively 1530 to 1740 residues) of O07944|SNBDE PRISTINAMYCIN I SYNTHASE 3 AND 4 from Streptomyces pristinaespiralis (4848 aa), FASTA scores: opt: 159, E(): 0.11, (30.35% identity in 224 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB07087.1" /db_xref="GI:1877323" /db_xref="GOA:P96873" /db_xref="InterPro:IPR000873" /db_xref="UniProtKB/TrEMBL:P96873" /translation="MLRADPVGPRITYYDDATGERIELSAVTLANWAAKTGNLLRDEL AAGPASRVAILLPAHWQTAAVLFGVWWIGAQAILDDSPADVALCTADRLAEADAVVNS AAVAGEVAVLSLDPFGRPATGLPVGVTDYATAVRVHGDQIVPEHNPGPVLAGRSVEQI LRDCAASAAARGLTAADRVLSTASWAGPDELVDGLLAILAAGASLVQVANPDPAMLQR RIATEKVTRVL" gene 182571..182852 /locus_tag="Rv3269" CDS 182571..182852 /locus_tag="Rv3269" /function="UNKNOWN. MAY BE INVOLVED IN A CHAPERONING PROCESS." /experiment="experimental evidence, no additional details recorded" /note="Rv3269, (MTCY71.09), len: 93 aa. Conserved hypothetical protein, similar to many Mycobacterium proteins and chaperonins/heat shock proteins e.g. Q9CCL0|ML0748 HYPOTHETICAL PROTEIN from Mycobacterium leprae (92 aa), FASTA scores: opt: 427, E(): 6.8e-21, (73.65% identity in 91 aa overlap); Q10865|Rv1993c|MT2049|MTCY39.26c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (90 aa), FASTA scores: opt: 313, E(): 1.2e-13, (60.7% identity in 84 aa overlap); P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c (98 aa), FASTA scores: opt: 294, E(): 2.2e-12, (55.1% identity in 98 aa overlap); Q50827|MOPA|GROEL|CH60_MYCVA CHAPERONIN (PROTEIN CPN60) from Mycobacterium vaccae (120 aa), FASTA scores: opt: 107, E(): 2.1, (39.5% identity in 81 aa overlap); Q9AEB3|HSP65 HEAT SHOCK PROTEIN (FRAGMENT) from Mycobacterium gadium (122 aa), FASTA scores: opt: 102, E(): 4.4, (38.25% identity in 81 aa overlap); Q49374|CH60_MYCGN|MOPA|GROEL CHAPERONIN (PROTEIN CPN60) from Mycobacterium genavense (120 aa), FASTA scores: opt: 99, E(): 6.8, (40.25% identity in 82 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB07088.1" /db_xref="GI:1877324" /db_xref="InterPro:IPR009963" /db_xref="UniProtKB/TrEMBL:P96874" /translation="MAIQVFLAKATTTVITGLAGVTAYEILKKAAAKAPLRQTAVSAA ALGLRGTRKAEEAAESARLKVADVMAEARERIGEESPTPAISDLHDHDH" gene 182863..185019 /gene="ctpC" /locus_tag="Rv3270" CDS 182863..185019 /gene="ctpC" /locus_tag="Rv3270" /EC_number="3.6.3.-" /function="METAL CATION-TRANSPORTING ATPASE; POSSIBLY CATALYZES THE TRANSPORT OF UNDETERMINED METAL CATION WITH THE HYDROLYSE OF ATP [CATALYTIC ACTIVITY: ATP + H(2)O + UNDETERMINATED METAL CATION(IN) = ADP + PHOSPHATE + UNDETERMINATED METAL CATION(OUT)]." /note="Rv3270, (MT3370, MTCY71.10), len: 718 aa. Probable ctpC, metal cation-transport ATPase P-type (EC 3.6.3.-), integral membrane protein, equivalent to Q9CCL1|CTPC|ML0747 PUTATIVE CATION TRANSPORT ATPASE from Mycobacterium leprae (725 aa), FASTA scores: opt: 3908, E(): 0, (85.95% identity in 713 aa overlap). Also similar to O66027|MTAA METAL TRANSPORTING ATPASE MTA72 from Mycobacterium tuberculosis (680 aa), FASTA scores: opt: 3756, E(): 5.5e-213, (91.45% identity in 679 aa overlap); and to other ATPases e.g. Q9ZHC7|SILP_SALTY PUTATIVE CATION TRANSPORTING P-TYPE ATPASE from Salmonella typhimurium (824 aa), FASTA scores: opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa overlap); Q9HX93|PA3920 PROBABLE METAL TRANSPORTING P-TYPE ATPASE from Pseudomonas aeruginosa (792 aa), FASTA scores: opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB." /codon_start=1 /transl_table=11 /product="PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C CTPC" /protein_id="CAB07083.1" /db_xref="GI:1877325" /db_xref="GOA:P0A502" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR005834" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006404" /db_xref="InterPro:IPR006416" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR009078" /db_xref="UniProtKB/Swiss-Prot:P0A502" /translation="MTLEVVSDAAGRMRVKVDWVRCDSRRAVAVEEAVAKQNGVRVVH AYPRTGSVVVWYSPRRADRAAVLAAIKGAAHVAAELIPARAPHSAEIRNTDVLRMVIG GVALALLGVRRYVFARPPLLGTTGRTVATGVTIFTGYPFLRGALRSLRSGKAGTDALV SAATVASLILRENVVALTVLWLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWVRLTD PSAGSDAATEIQVPIDTVQIGDEVVVHEHVAIPVDGEVVDGEAIVNQSAITGENLPVS VVVGTRVHAGSVVVRGRVVVRAHAVGNQTTIGRIISRVEEAQLDRAPIQTVGENFSRR FVPTSFIVSAIALLITGDVRRAMTMLLIACPCAVGLSTPTAISAAIGNGARRGILIKG GSHLEQAGRVDAIVFDKTGTLTVGRPVVTNIVAMHKDWEPEQVLAYAASSEIHSRHPL AEAVIRSTEERRISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLRAEKVRVSKKAS EWVDKLRRQAETPLLLAVDGTLVGLISLRDEVRPEAAQVLTKLRANGIRRIVMLTGDH PEIAQVVADELGIDEWRAEVMPEDKLAAVRELQDDGYVVGMVGDGINDAPALAAADIG IAMGLAGTDVAVETADVALANDDLHRLLDVGDLGERAVDVIRQNYGMSIAVNAAGLLI GAGGALSPVLAAILHNASSVAVVANSSRLIRYRLDR" misc_feature 184084..184104 /gene="ctpC" /locus_tag="Rv3270" /note="PS00154 E1-E2 ATPases phosphorylation site" gene complement(185016..185684) /locus_tag="Rv3271c" CDS complement(185016..185684) /locus_tag="Rv3271c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3271c, (MTCY71.11c), len: 222 aa. Probable conserved integral membrane protein, similar to others e.g. Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa), FASTA scores: opt: 360, E(): 4.7e-16, (33.85% identity in 195 aa overlap); Q9X897|SCE2.02c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 357, E(): 7.3e-16, (33.85% identity in 195 aa overlap); Q9D0E0 2610024A01RIK PROTEIN from Mus musculus (Mouse) (288 aa), FASTA scores: opt: 191, E(): 3.7e-05, (23.65% identity in 207 aa overlap)." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" /protein_id="CAB07084.1" /db_xref="GI:1877326" /db_xref="GOA:P96876" /db_xref="InterPro:IPR002524" /db_xref="UniProtKB/TrEMBL:P96876" /translation="METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLL TEGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVA VSFWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSG ATAGEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGH GCGC" gene 185785..186969 /locus_tag="Rv3272" CDS 185785..186969 /locus_tag="Rv3272" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3272, (MTCY71.12), len: 394 aa. Conserved hypothetical protein, similar to various proteins e.g. Q9I672|PA0446 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (407 aa), FASTA scores: opt: 643, E(): 6.8e-32, (33.15% identity in 389 aa overlap); Q9RJU8|SCF41.21 PUTATIVE RACEMASE from Streptomyces coelicolor (403 aa), FASTA scores: opt: 541, E(): 1.1e-25, (31.95% identity in 385 aa overlap); O87838|SC8A6.04c PUTATIVE TRANSFERASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 539, E(): 1.5e-25, (29.95% identity in 395 aa overlap); Q9I563|PA0882 from Pseudomonas aeruginosa (400 aa), FASTA scores: opt: 530, E(): 5.2e-25, (28.8% identity in 396 aa overlap); BAB60328|TVG1215416 L-CARNITINE DEHYDRATASE from Thermoplasma volcanium (399 aa), FASTA scores: opt: 529, E(): 6e-25, (32.9% identity in 383 aa overlap); etc. C-terminus is similar to Q49678|U00012_27|B1308_C3_195 from Mycobacterium leprae (130 aa) (60.0% identity in 115 aa overlap). Also partially similar to MTCY359_7 from M. tuberculosis (778 aa) (29.9% identity in 388 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB07085.1" /db_xref="GI:1877327" /db_xref="GOA:P96877" /db_xref="InterPro:IPR003673" /db_xref="UniProtKB/TrEMBL:P96877" /translation="MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP GGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEA FRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEAGMTTGMP TPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQANQL MMHLNRAASDQPKPEPAPKAKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCY LIGRPDLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHT WKQVVDTPLFAENDLTLEVGRGADTITVIRTPARYASFRAVVTDPPPTAGEHNAVFLA RP" gene 186974..189268 /locus_tag="Rv3273" CDS 186974..189268 /locus_tag="Rv3273" /EC_number="4.2.1.1" /function="GENERATES CO(2) AND H(2)O FROM H(2)CO(3), AND POSSIBLY INVOLVED IN TRANSPORT OF SULFATE ACROSS THE MEMBRANE." /experiment="experimental evidence, no additional details recorded" /note="Rv3273, (MTCY71.13), len: 764 aa. Probable transmembrane protein (N-terminal part is hydrophobic) with probable carbonic anhydrase activity (in C-terminal part) (EC 4.2.1.1). Possibly involved in transport of sulfate. Equivalent to Q9CBA3|ML2279 PUTATIVE TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium leprae (496 aa), FASTA scores: opt: 1637, E(): 1.8e-89, (59.15% identity in 487 aa overlap). Similar to various proteins (principally sulfate transporters) e.g. Q9X927|SCH5.25 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (830 aa), FASTA scores: opt: 1325, E(): 8e-71, (40.85% identity in 788 aa overlap); Q9I729|PA0103 PROBABLE SULFATE TRANSPORTER from Pseudomonas aeruginosa (523 aa), FASTA scores: opt: 1015, E(): 1.3e-52, (39.95% identity in 488 aa overlap); Q9KN88|VCA0077 SULFATE PERMEASE FAMILY PROTEIN from Vibrio cholerae (553 aa), FASTA scores: opt: 629, E(): 9.6e-30, (30.95% identity in 423 aa overlap); etc. C-terminal part (aa 550-764) shows similarity to carbonic anhydrase e.g. P27134|CYNT_SYNP7 CARBONIC ANHYDRASE (EC 4.2.1.1) (272 aa), FASTA scores: opt: 350, E(): 8.1e-15, (33.8% identity in 201 aa overlap). Contains PS00704 Prokaryotic-type carbonic anhydrases signature 1. SEEMS TO BELONG TO THE SULP FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)" /protein_id="CAB07076.1" /db_xref="GI:1877328" /db_xref="GOA:P96878" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR011547" /db_xref="UniProtKB/TrEMBL:P96878" /translation="MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLV ALPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDEL GWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGG TSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGA TVLALLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIAS VESLLSAVGVDKLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIVRSSANVAAGA RTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNF VIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDG TLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVE TSPAKLHHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHP HIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAA LDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHP ARRSAESAGYPEADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVY EVGPNGIICPDEPADRPVDHESAQ" misc_feature 188723..188746 /locus_tag="Rv3273" /note="PS00704 Prokaryotic-type carbonic anhydrases signature 1" gene complement(189257..190426) /gene="fadE25" /locus_tag="Rv3274c" CDS complement(189257..190426) /gene="fadE25" /locus_tag="Rv3274c" /EC_number="1.3.99.-" /function="UNKNOWN, BUT INVOLVED IN LIPID DEGRADATION [CATALYTIC ACTIVITY: ACYL-CoA + ETF = 2,3-DEHYDROACYL-CoA + REDUCED ETF]." /experiment="experimental evidence, no additional details recorded" /note="Rv3274c, (MTCY71.14c), len: 389 aa. Probable fadE25, Acyl-CoA Dehydrogenase (EC 1.3.99.-), equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 PROBABLE ACYL-CoA DEHYDROGENASE FADE25 from Mycobacterium leprae (389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05% identity in 389 aa overlap). Also similar to many e.g. Q9RIQ5|FADE FATTY ACID ACYL-CoA DEHYDROGENASE from Streptomyces lividans (385 aa), FASTA scores: opt: 1692, E(): 4.9e-99, (67.35% identity in 383 aa overlap); P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa), FASTA scores: opt: 1212, E(): 7.2e-69, (51.85% identity in 376 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 1209, E(): 1.1e-68, (51.7% identity in 377 aa overlap); P52042|ACDS_CLOAB|BCD from Clostridium acetobutylicum (379 aa), FASTA scores: opt: 1056, E(): 4.6e-59, (44.6% identity in 379 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA dehydrogenases signature 2. BELONGS TO THE ACYL-COA DEHYDROGENASES FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE ACYL-CoA DEHYDROGENASE FADE25" /protein_id="CAB07077.1" /db_xref="GI:1877329" /db_xref="GOA:P63427" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006090" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR006092" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="UniProtKB/Swiss-Prot:P63427" /translation="MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEK ARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVNKL GTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILN GAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPT TELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKD RKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFAS DVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR" misc_feature complement(189332..189391) /gene="fadE25" /locus_tag="Rv3274c" /note="PS00073 Acyl-CoA dehydrogenases signature 2" misc_feature complement(189992..190030) /gene="fadE25" /locus_tag="Rv3274c" /note="PS00072 Acyl-CoA dehydrogenases signature 1" gene complement(190451..190975) /gene="purE" /locus_tag="Rv3275c" CDS complement(190451..190975) /gene="purE" /locus_tag="Rv3275c" /EC_number="4.1.1.21" /function="INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP). THIS SUBUNIT CAN ALONE TRANSFORM AIR TO CAIR, BUT IN ASSOCIATION WITH PURK, WHICH POSSESSES AN ATPASE ACTIVITY, AN ENZYME COMPLEX IS PRODUCED WHICH IS CAPABLE OF CONVERTING AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL CONDITION [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE = 1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)]." /experiment="experimental evidence, no additional details recorded" /note="Rv3275c, (MTCY71.15c, PUR6), len: 174 aa. Probable purE, phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21), equivalent to P46702|PUR6_MYCLE|PURE|ML0736|B1308_F3_98 from Mycobacterium leprae (171 aa), FASTA scores: opt: 878, E(): 1.5e-43, (81.55% identity in 168 aa overlap). Also similar to others e.g. Q9AXD0|AIRC from Nicotiana tabacum (Common tobacco) (623 aa), FASTA scores: opt: 712, E(): 1.4e-33, (69.35% identity in 160 aa overlap) (similarity in C-terminal part for this one); Q44679|PUR6_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (177 aa), FASTA scores: opt: 651, E(): 1.5e-30, (68.25% identity in 148 aa overlap); Q55498|PUR6_SYNY3|PURE|SLL0901 from Synechocystis sp. strain PCC 6803 (176 aa), FASTA scores: opt: 639, E(): 7.1e-30, (60.5% identity in 167 aa overlap); etc." /codon_start=1 /transl_table=11 /product="PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT PURE (AIR CARBOXYLASE) (AIRC)" /protein_id="CAB07078.1" /db_xref="GI:1877330" /db_xref="GOA:P96880" /db_xref="InterPro:IPR000031" /db_xref="UniProtKB/Swiss-Prot:P96880" /translation="MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSA HRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLD SLLSIVQMPAGVPVATVSIGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAK DAELQRLAGKLTRD" gene complement(190972..192261) /gene="purK" /locus_tag="Rv3276c" CDS complement(190972..192261) /gene="purK" /locus_tag="Rv3276c" /EC_number="4.1.1.21" /function="INVOLVED IN PURINE BIOSYNTHESIS (SIXTH STEP). POSSESSES AN ATPASE ACTIVITY THAT IS DEPENDENT ON THE PRESENCE OF AIR (AMINOIMIDAZOLE RIBONUCLEOTIDE). THE ASSOCIATION OF PURK AND PURE PRODUCES AN ENZYME COMPLEX CAPABLE OF CONVERTING AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL CONDITION [CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE-CARBOXYLATE = 1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2)]." /note="Rv3276c, (MTCY71.16c), len: 429 aa. Probable purK, phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21), equivalent to P46701|PURK_MYCLE|ML0735|B1308_F1_32 PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT from Mycobacterium leprae (439 aa), FASTA scores: opt: 2168, E(): 2.3e-123, (76.15% identity in 444 aa overlap). Also similar to others e.g. Q44678|PURK_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (413 aa), FASTA scores: opt: 1179, E(): 9.1e-64, (48.35% identity in 389 aa overlap); Q9KZ85|PURK from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1150, E(): 4.7e-62, (55.35% identity in 345 aa overlap); Q54975|PURK_SYNP7 from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (395 aa), FASTA scores: opt: 772, E(): 3e-39, (38.1% identity in 383 aa overlap); etc. BELONGS TO THE PURK / PURT FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT PURK (AIR CARBOXYLASE) (AIRC)" /protein_id="CAB07079.1" /db_xref="GI:1877331" /db_xref="GOA:P65898" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR011054" /db_xref="UniProtKB/Swiss-Prot:P65898" /translation="MMAVASSRTPAVTSFIAPLVAMVGGGQLARMTHQAAIALGQNLR VLVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGADVLTFDHEHVPNELLEKLVADGV NVAPSPQALVHAQDKLVMRQRLAAAGVAVPRYAGIKDPDEIDVFAARVDAPIVVKAVR GGYDGRGVRMARDVADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAW PVVQTVQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETTDGA LLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPVTVMANVLGAAQ PPAMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGSDVAQLCERAELAAHW LSHGRWTDGWDPHRASDDAVGVPPACGGRSDEEERRL" repeat_unit complement(190995..191052) /gene="purK" /locus_tag="Rv3276c" /note="58 bp Mycobacterial Interspersed Repetitive Unit, Class III" gene 192215..193033 /locus_tag="Rv3277" CDS 192215..193033 /locus_tag="Rv3277" /function="UNKNOWN" /note="Rv3277, (MTCY71.17), len: 272 aa. Probable conserved transmembrane protein, equivalent, but longer 49 aa, to Q49673|B1308_C1_121|ML0734 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (228 aa), FASTA scores: opt: 1266, E(): 6.1e-78, (84.2% identity in 228 aa overlap). Also similar to various proteins (principally unknowns) e.g. Q9KZ84|SCE25.02 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (190 aa), FASTA scores: opt: 197, E(): 3.6e-06, (32.0% identity in 150 aa overlap); BAB50058|MLL3086 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (136 aa), FASTA scores: opt: 176, E(): 6.9e-05, (34.7% identity in 147 aa overlap); O29640|AF0615 HYPOTHETICAL PROTEIN from Archaeoglobus fulgidus (129 aa), FASTA scores: opt: 120, E(): 0.38, (23.35% identity in 120 aa overlap); Q9KJU8|GTCA TEICHOIC ACID GLYCOSYLATION PROTEIN from Listeria innocua (145 aa), FASTA scores: opt: 117, E(): 0.67, (23.85% identity in 151 aa overlap); etc. Equivalent to AAK47718 from Mycobacterium tuberculosis strain CDC1551 (256 aa) but longer 16 aa. Contains PS00044 Bacterial regulatory proteins, lysR family signature." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" /protein_id="CAB07080.1" /db_xref="GI:1877332" /db_xref="GOA:P96882" /db_xref="InterPro:IPR007267" /db_xref="UniProtKB/TrEMBL:P96882" /translation="MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSS VHSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEP KPVTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWF SSYILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKAL ESALTAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS" misc_feature 192650..192727 /locus_tag="Rv3277" /note="PS00044 Bacterial regulatory proteins, lysR family signature" gene complement(192988..193506) /locus_tag="Rv3278c" CDS complement(192988..193506) /locus_tag="Rv3278c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3278c, (MTCY71.18c), len: 172 aa. Probable conserved transmembrane protein, equivalent to Q9CCL2|ML0733 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (172 aa), FASTA scores: opt: 1024, E(): 6e-61, (83.15% identity in 172 aa overlap); and Q49672|B1308_F2_67 HYPOTHETICAL PROTEIN from Mycobacterium leprae (181 aa), FASTA scores: opt: 1024, E(): 6.3e-61, (83.15% identity in 172 aa overlap) (this is certainly the same putative protein but with N-terminus longer). Also some similarity to other hypothetical proteins (generally membrane proteins) e.g. O26822|MTH726 HYPOTHETICAL PROTEIN from Methanobacterium thermoautotrophicum (204 aa), FASTA scores: opt: 147, E(): 0.0079, (24.6% identity in 187 aa overlap); Q9X8H4|SCE9.01 HYPOTHETICAL 47.7 KDA PROTEIN (FRAGMENT) from Streptomyces coelicolor (436 aa), FASTA scores: opt: 151, E(): 0.0079, (28.1% identity in 153 aa overlap)." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED TRANSMEMBRANE PROTEIN" /protein_id="CAB07081.1" /db_xref="GI:1877333" /db_xref="GOA:P96883" /db_xref="InterPro:IPR005182" /db_xref="UniProtKB/TrEMBL:P96883" /translation="MSYPENVLAAGEQVVLHRHPHWNRLIWPVVVLVLLTGLAAFGSG FVNSTPWQQIAKNVIHAVIWGIWLVIVGWLTLWPFLSWLTTHFVVTNRRVMFRHGVLT RSGIDIPLARINSVEFRDRIFERIFRTGTLIIESASQDPLEFYNIPRLREVHALLYHE VFDTLGSDESPS" gene complement(193549..194349) /gene="birA" /locus_tag="Rv3279c" CDS complement(193549..194349) /gene="birA" /locus_tag="Rv3279c" /EC_number="6.3.4.15" /function="BIRA ACTS BOTH AS A BIOTIN-OPERON REPRESSOR AND AS THE ENZYME THAT SYNTHESIZES THE COREPRESSOR, ACETYL-COA:CARBON-DIOXIDE LIGASE. THIS PROTEIN ALSO ACTIVATES BIOTIN TO FORM BIOTINYL-5'-ADENYLATE AND TRANSFERS THE BIOTIN MOIETY TO BIOTIN-ACCEPTING PROTEINS [CATALYTIC ACTIVITY: ATP + BIOTIN + APO-[ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP FORMING)] = AMP + PYROPHOSPHATE + [ACETYL-COA:CARBON-DIOXIDE LIGASE (ADP FORMING)]]." /experiment="experimental evidence, no additional details recorded" /note="Rv3279c, (MTCY71.19c), len: 266 aa. Possible birA, bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15), equivalent to Q9CCL3|BIRA|ML0732 BIOTIN APO-PROTEIN LIGASE from Mycobacterium leprae (274 aa), FASTA scores: opt: 1189, E(): 2.3e-66, (71.2% identity in 271 aa overlap). But as it lacks a BirA h-t-h domain at N-terminus, may simply be biotin apo-protein ligase. Also similar to others e.g. Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312 aa), FASTA scores: opt: 347, E(): 2.7e-14, (32.95% identity in 270 aa overlap); Q9HWC0|BIRA|PA4280 from Pseudomonas aeruginosa (312 aa), FASTA scores: opt: 335, E(): 1.5e-13, (34.2% identity in 272 aa overlap); Q9A6Z0|CC1936 from Caulobacter crescentus (250 aa), FASTA scores: opt: 332, E(): 1.9e-13, (33.6% identity in 238 aa overlap); P06709|BIRA_ECOLI (321 aa), FASTA scores: opt: 314, E(): 3.1e-12, (34.15% identity in 249 aa overlap); etc. SIMILAR WITH OTHER BACTERIAL BIRA AND WITH EUKARYOTIC BIOTIN APO-PROTEIN LIGASE." /codon_start=1 /transl_table=11 /product="POSSIBLE BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGASE)" /protein_id="CAB07082.1" /db_xref="GI:1877334" /db_xref="GOA:P96884" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="UniProtKB/TrEMBL:P96884" /translation="MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLL ARAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLS LAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVT QAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLT IGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR" gene 194399..196045 /gene="accD5" /locus_tag="Rv3280" CDS 194399..196045 /gene="accD5" /locus_tag="Rv3280" /EC_number="6.4.1.3" /function="KEY ENZYME IN THE CATABOLIC PATHWAY OF ODD-CHAIN FATTY ACIDS, ISOLEUCINE, THREONINE, METHIONINE, AND VALINE [CATALYTIC ACTIVITY: ATP + PROPIONYL-CoA + CO(2) + H(2)O = ADP + ORTHOPHOSPHATE + METHYLMALONYL-COA.]" /experiment="experimental evidence, no additional details recorded" /note="Rv3280, (MTCY71.20, pccB), len: 548 aa. Probable accD5, propyonyl-CoA carboxylase beta chain 5 (EC 6.4.1.3), equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 5 from Mycobacterium leprae (549 aa), FASTA scores: opt: 3241, E(): 4e-192, (88.7% identity in 549 aa overlap). Also similar to many e.g. O87201|DTSR2 DTSR2 PROTEIN INVOLVED IN GLUTAMATE PRODUCTION from orynebacterium glutamicum (Brevibacterium flavum) (537 aa), FASTA scores: opt: 2604, E(): 6.9e-153, (74.1% identity in 529 aa overlap) (see Kimura et al., 1996); P53003|PCCB_SACER from Saccharopolyspora erythraea (Streptomyces erythraeus) (546 aa), FASTA scores: opt: 2466, E(): 2.2e-144, (70.2% identity in 530 aa overlap); O88155|DTSR1 DTSR1 PROTEIN from Corynebacterium glutamicum (Brevibacterium flavum) (543 aa), FASTA scores: opt: 2375, E(): 8.8e-139, (67.1% identity in 529 aa overlap; Q9X4K7|PCCB from Streptomyces coelicolor (530 aa), FASTA scores: opt: 2360, E(): 7.3e-138, (67.9% identity in 533 aa overlap); O24789|MXPCCB from Myxococcus xanthus (524 aa), FASTA scores: opt: 1868, E(): 1.5e-107, (56.85% identity in 524 aa overlap); etc. Also similar with METHYLMALONYL-CoA DECARBOXYLASES e.g. O59018|PH1287 from Pyrococcus horikoshii (522 aa), FASTA scores: opt: 1841, E(): 6.7e-106, (54.15% identity in 528 aa overlap). Also similarity with MTCY427.28 (43.8% identity in 434 aa overlap). BELONGS TO THE ACCD/PCCB FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 5 ACCD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)" /protein_id="CAB07063.1" /db_xref="GI:1877335" /db_xref="GOA:P96885" /db_xref="InterPro:IPR000022" /db_xref="UniProtKB/Swiss-Prot:P96885" /translation="MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVG EDAVEKVHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVTGY GTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEG VVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITG PDVIKTVTGEEVTMEELGGAHTHMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTD APRYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYA QNIVVGFGRIDGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVP GFLPGTDQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNL AWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDTLVNPYVAAER GYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL" gene 196026..196559 /locus_tag="Rv3281" CDS 196026..196559 /locus_tag="Rv3281" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3281, (MTCY71.21), len: 177 aa. Conserved hypothetical protein, equivalent (but longer 14 aa and with a gap between aa 82-102) to AAK47723|MT3380 from Mycobacterium tuberculosis strain CDC1551 (142 aa), FASTA scores: opt: 830, E(): 3.1e-40, (86.5% identity in 163 aa overlap). C-terminus highly similar to Q49671|B1308_C3_211|ML0730 from Mycobacterium leprae (84 aa), FASTA scores: opt: 393, E(): 7.6e-16, (68.95% identity in 87 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB07064.1" /db_xref="GI:1877336" /db_xref="UniProtKB/TrEMBL:P96886" /translation="MGTCPCESSERNEPVSRVSGTNEVSDGNETNNPAEVSDGNETNN PAEVSDGNETNNPAPVSRVSGTNEVSDGNETNNPAPVSRVSGTNEVSDGNETNNPAPV TEKPLHPHEPHIEILRGQPTDQELAALIAVLGSISGSTPPAQPEPTRWGLPVDQLRYP VFSWQRITLQEMTHMRR" gene 196556..197224 /locus_tag="Rv3282" CDS 196556..197224 /locus_tag="Rv3282" /function="UNKNOWN" /note="Rv3282, (MTCY71.22), len: 222 aa. Conserved hypothetical protein, equivalent to Q49670|ML0729 1308R (HYPOTHETICAL PROTEIN ML0729) from Mycobacterium leprae (213 aa), FASTA scores: opt: 945, E(): 5.5e-54, (68.55% identity in 213 aa overlap). Also similar to Q9EWV6|2SCK31.18 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (206 aa), FASTA scores: opt: 459, E(): 1.3e-22, (47.35% identity in 209 aa overlap); P74331|MAF OR SLL0905 MAF PROTEIN from Synechocystis sp. strain PCC 6803 (195 aa), FASTA scores: opt: 401, E(): 6.9e-19, (43.0% identity in 207 aa overlap); and shows weak similarity with various proteins e.g. Q9BUL6 ACETYLSEROTONIN O-METHYLTRANSFERASE-LIKE from Homo sapiens (Human) (621 aa), FASTA scores: opt: 282, E(): 8.9e-11, (31.6% identity in 193 aa overlap); O95671|ASMTL ASMTL PROTEIN from Homo sapiens (Human) (629 aa), FASTA scores: opt: 282, E(): 9e-11, (31.6% identity in 193 aa overlap); BAB51136|MLR4491 MAF PROTEIN from Rhizobium loti (Mesorhizobium loti) (199 aa), FASTA scores: opt: 269, E(): 2.3e-10, (29.3% identity in 198 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB07065.1" /db_xref="GI:1877337" /db_xref="GOA:P96887" /db_xref="InterPro:IPR003697" /db_xref="UniProtKB/Swiss-Prot:P96887" /translation="MTRLVLGSASPGRLKVLRDAGIEPLVIASHVDEDVVIAALGPDA VPSDVVCVLAAAKAAQVATTLTGTQRIVAADCVVVACDSMLYIEGRLLGKPASIDEAR EQWRSMAGRAGQLYTGHGVIRLQDNKTVYRAAETAITTVYFGTPSASDLEAYLASGES LRVAGGFTLDGLGGWFIDGVQGNPSNVIGLSLPLLRSLVQRCGLSVAALWAGNAGGPA HKQQ" gene 197265..198158 /gene="sseA" /locus_tag="Rv3283" CDS 197265..198158 /gene="sseA" /locus_tag="Rv3283" /EC_number="2.8.1.1" /function="POSSIBLY A SULFOTRANSFERASE INVOLVED IN THE FORMATION OF THIOSULFATE [CATALYTIC ACTIVITY: THIOSULFATE + CYANIDE = SULFITE + THIOCYANATE]." /experiment="experimental evidence, no additional details recorded" /note="Rv3283, (MTCY71.23), len: 297 aa. Probable sseA, thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 PUTATIVE THIOSULFATE SULFURTRANSFERASE SSEA from Mycobacterium leprae (296 aa), FASTA scores: opt: 1742, E(): 5.5e-108, (83.45% identity in 296 aa overlap). Also highly similar to others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans (286 aa), FASTA scores: opt: 1057, E(): 1.2e-62, (53.86% identity in 273 aa overlap); P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea (Streptomyces erythraeus) (281 aa), FASTA scores: opt: 1006, E(): 2.7e-59, (51.25% identity in 277 aa overlap); P71121|THTR_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (225 aa), FASTA scores: opt: 897, E(): 3.6e-52, (59.05% identity in 215 aa overlap); etc. Also highly similar to O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c| MT 0837|MTV043.07c|THTR_MYCTU PUTATIVE THIOSULFATE SULFURTRANSFERASE (EC 2.8.1.1) from Mycobacterium tuberculosis (277 aa), FASTA scores: opt: 955, E(): 6.3e-56, (50.2% identity in 271 aa overlap); and Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 PUTATIVE THIOSULFATE SULFURTRANSFERASE from Mycobacterium leprae (277 aa), FASTA scores: opt: 931, E(): 2.5e-54, (48.9% identity in 276 aa overlap). Shows some similarity to MTCY339.19c (30.3% identity in 254 aa overlap). Contains PS00683 Rhodanese C-terminal signature. BELONGS TO THE RHODANESE FAMILY. Thought to be differentially expressed within host cells (see Triccas et al., 1999)." /codon_start=1 /transl_table=11 /product="PROBABLE THIOSULFATE SULFURTRANSFERASE SSEA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)" /protein_id="CAB07066.1" /db_xref="GI:1877338" /db_xref="GOA:P96888" /db_xref="InterPro:IPR001307" /db_xref="InterPro:IPR001763" /db_xref="UniProtKB/Swiss-Prot:P96888" /translation="MPLPADPSPTLSAYAHPERLVTADWLSAHMGAPGLAIVESDEDV LLYDVGHIPGAVKIDWHTDLNDPRVRDYINGEQFAELMDRKGIARDDTVVIYGDKSNW WAAYALWVFTLFGHADVRLLNGGRDLWLAERRETTLDVPTKTCTGYPVVQRNDAPIRA FRDDVLAILGAQPLIDVRSPEEYTGKRTHMPDYPEEGALRAGHIPTAVHIPWGKAADE SGRFRSREELERLYDFINPDDQTVVYCRIGERSSHTWFVLTHLLGKADVRNYDGSWTE WGNAVRVPIVAGEEPGVVPVV" misc_feature 198072..198095 /gene="sseA" /locus_tag="Rv3283" /note="PS00683 Rhodanese C-terminal signature" gene 198155..198586 /locus_tag="Rv3284" CDS 198155..198586 /locus_tag="Rv3284" /function="UNKNOWN" /note="Rv3284, (MTCY71.24, unknown), len: 143 aa. Conserved hypothetical protein, with similarity to other bacterial hypothetical proteins e.g. Q9RXU0|DR0216 from Deinococcus radiodurans (147 aa), FASTA scores: opt: 425, E(): 9.1e-21, (46.55% identity in 146 aa overlap); BAB37094|ECS3671 from Escherichia coli strain O157:H7 (147 aa), FASTA scores: opt: 187, E(): 2.2e-05, (29.5% identity in 139 aa overlap); AAG57925|YGDK from Escherichia coli strain O157:H7 EDL933 (147 aa), FASTA scores: opt: 187, E(): 2.2e-05, (32.05% identity in 139 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB07067.1" /db_xref="GI:1877339" /db_xref="InterPro:IPR003808" /db_xref="UniProtKB/Swiss-Prot:P67123" /translation="MTAPASLPAPLAEVVSDFAEVQGQDKLRLLLEFANELPALPSHL AESAMEPVPECQSPLFLHVDASDPNRVRLHFSAPAEAPTTRGFASILAAGLDEQPAAD ILAVPEDFYTELGLAALISPLRLRGMSAMLARIKRRLREAD" gene 198694..200496 /gene="accA3" /locus_tag="Rv3285" CDS 198694..200496 /gene="accA3" /locus_tag="Rv3285" /EC_number="6.3.4.14" /function="INVOLVED IN LONG-CHAIN FATTY ACID SYNTHESIS (AT THE FIRST STEP). CARRIES TWO FUNCTIONS: BIOTIN CARBOXYL CARRIER PROTEIN AND BIOTIN CARBOXYLTRANSFERASE [CATALYTIC ACTIVITY: ATP + BIOTIN-CARBOXYL-CARRIER PROTEIN + CO(2) = ADP + ORTHOPHOSPHATE + CARBOXYBIOTIN-CARBOXYL-CARRIER PROTEIN]." /experiment="experimental evidence, no additional details recorded" /note="Rv3285, (MTCY71.25), len: 600 aa. Probable accA3, bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (EC 6.3.4.14) (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129 ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE ALPHA CHAIN from Mycobacterium leprae (598 aa), FASTA scores: opt: 3510, E(): 1.1e-196, (89.3% identity in 601 aa overlap). Also highly similar to other proteins e.g. P71122|ACCBC ACYL COENZYME A CARBOXYLASE from Corynebacterium glutamicum (Brevibacterium flavum) (591 aa), FASTA scores: opt: 2776, E(): 5.6e-154, (71.95% identity in 592 aa overlap); Q54119|BCPA2 BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (591 aa), FASTA scores: opt: 2723, E(): 6.7e-151, (70.5% identity in 590 aa overlap); Q54105|BCPA BIOTIN CARBOXYLASE AND BIOTIN CARBOXYL CARRIER PROTEIN from Saccharopolyspora erythraea (Streptomyces erythraeus) (597 aa), FASTA scores: opt: 2721, E(): 8.9e-151, (70.05% identity in 594 aa overlap); Q9EWV4|2SCK31.20 PUTATIVE ACYL-CoA CARBOXYLASE COMPLEX A SUBUNIT from Streptomyces coelicolor (590 aa), FASTA scores: opt: 2626, E(): 2.9e-145, (68.25% identity in 595 aa overlap); etc. Contains PS00867 Carbamoyl-phosphate synthase subdomain signature 2, PS00188 Biotin-requiring enzymes attachment site. SIMILAR TO OTHER BIOTIN-DEPENDENT ENZYMES AND CARBAMOYL-PHOSPHATE SYNTHETASES." /codon_start=1 /transl_table=11 /product="PROBABLE BIFUNCTIONAL PROTEIN ACETYL-/PROPIONYL-COENZYME A CARBOXYLASE (ALPHA CHAIN) ACCA3: BIOTIN CARBOXYLASE + BIOTIN CARBOXYL CARRIER PROTEIN (BCCP)" /protein_id="CAB07068.1" /db_xref="GI:1877340" /db_xref="GOA:P96890" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="UniProtKB/TrEMBL:P96890" /translation="MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAE PDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFA QAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEE YGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRH VEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEA HYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDIT EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFD SMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVH TRWIETEWNNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDP VGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMK MENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK" misc_feature 199579..199602 /gene="accA3" /locus_tag="Rv3285" /note="PS00867 Carbamoyl-phosphate synthase subdomain signature 2" misc_feature 200359..200412 /gene="accA3" /locus_tag="Rv3285" /note="PS00188 Biotin-requiring enzymes attachment site" gene complement(200506..201291) /gene="sigF" /locus_tag="Rv3286c" CDS complement(200506..201291) /gene="sigF" /locus_tag="Rv3286c" /function="THE SIGMA FACTOR IS AN INITIATION FACTOR THAT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC INITIATION SITES AND THEN IS RELEASED. THOUGHT TO BE INVOLVED IN SURVIVAL AND PROLIFERATION IN LUNG GRANULOMAS DURING INFECTION. THOUGHT TO BE INVOLVED IN VIRULENCE AND PERSISTENCE PROCESSES. MODULATES EXPRESSION OF THE 16 KDa ALPHA-CRYSTALLIN HOMOLOGUE/Rv2031c. NEGATIVELY REGULATED BY Rv3287c|RSBW|USFX." /experiment="experimental evidence, no additional details recorded" /note="Rv3286c, (MTCY71.26), len: 261 aa. sigF, stress response/stationary phase RNA polymerase sigma factor (see citations below), similar to several Streptomyces RNA polymerase sigma factors e.g. Q9RPC8|SIGH from Streptomyces coelicolor A3(2) (354 aa), FASTA scores: opt: 869, E(): 1.1e-45, (51.15% identity in 258 aa overlap); Q9RIT0|SIG1 from Streptomyces coelicolor (361 aa), FASTA scores: opt: 869, E(): 1.1e-45, (51.15% identity in 258 aa overlap); Q9ADM4|2SC10A7.38c from Streptomyces coelicolor (318 aa), FASTA scores: opt: 776, E(): 4.6e-40, (48.75% identity in 240 aa overlap); P37971|RPOF_STRCO|SIGF|RPOX|2SCD60.01c from Streptomyces coelicolor (287 aa), FASTA scores: opt: 717, E(): 1.6e-36, (44.5% identity in 245 aa overlap); P37970|RPOF_STRAU|SIGF|RPOX from Streptomyces aureofaciens (297 aa); etc. Contains possible helix-turn-helix motif at aa 229-250 (+7.38 SD). SIMILAR TO THE SIGMA-70 FACTOR FAMILY. Seems expressed in stationary phase and under stress conditions in vitro (see citations below)." /codon_start=1 /transl_table=11 /product="ALTERNATE RNA POLYMERASE SIGMA FACTOR SIGF" /protein_id="CAB07069.1" /db_xref="GI:1877341" /db_xref="GOA:Q7D5S2" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="UniProtKB/TrEMBL:Q7D5S2" /translation="MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIV QRCLPLADHIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGE VRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELGMDRAEVIE GLLAGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLLEALPERER TVLVLRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE" gene complement(201288..201725) /gene="rsbW" /locus_tag="Rv3287c" CDS complement(201288..201725) /gene="rsbW" /locus_tag="Rv3287c" /function="BINDS TO SIGMA AND BLOCKS ITS ABILITY TO FORM AN RNA POLYMERASE HOLOENZYME. REGULATES NEGATIVELY SIGF|Rv3286c, AND NEGATIVELY REGULATED BY Rv1365c|RSFA AND Rv3687C|RSFB." /standard_name="usfX" /experiment="experimental evidence, no additional details recorded" /note="Rv3287c, (MTCY71.27c), len: 145 aa. rsbW (alternate gene name: usfX), anti-sigma factor (see citations below), similar to Q49667|B1308_F3_89 from Mycobacterium leprae (75 aa), FASTA scores: opt: 308, E(): 2.5e-15, (72.2% identity in 72 aa overlap); Q9R3X8|PRS1|USHX|PRS PRS1 PROTEIN (ANTI-SIGMA FACTOR) from Streptomyces coelicolor (137 aa), FASTA scores: opt: 184, E(): 3.7e-06, (36.8% identity in 106 aa overlap); O50231 PUTATIVE SIGMA-B REGULATOR from Bacillus licheniformis (160 aa), FASTA scores: opt: 122, E(): 0.13, (23.9% identity in 92 aa overlap); and P17904|RSBW_BACSU ANTI-SIGMA B FACTOR (SIGMA-B NEGATIVE EFFECTOR RSBW) from Bacillus subtilis (160 aa), FASTA scores: opt: 108, E(): 1.3, (21.25% identity in 127 aa overlap). Equivalent to AAK47729 from Mycobacterium tuberculosis strain CDC1551 (145 aa) but longer 99 aa. INDUCTION BY HEAT SHOCK, SALT STRESS, OXIDATIVE STRESS, GLUCOSE LIMITATION AND OXYGEN LIMITATION. N-terminus shortened since first submission (previously 242 aa)." /codon_start=1 /transl_table=11 /product="ANTI-SIGMA FACTOR RSBW (SIGMA NEGATIVE EFFECTOR)" /protein_id="CAB07095.2" /db_xref="GI:38490348" /db_xref="UniProtKB/TrEMBL:Q7D5S1" /translation="MADSDLPTKGRQRGVRAVELNVAARLENLALLRTLVGAIGTFED LDFDAVADLRLAVDEVCTRLIRSALPDATLRLVVDPRKDEVVVEASAACDTHDVVAPG SFSWHVLTALADDVQTFHDGRQPDVAGSVFGITLTARRAASSR" gene complement(201923..202336) /gene="usfY" /locus_tag="Rv3288c" CDS complement(201923..202336) /gene="usfY" /locus_tag="Rv3288c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3288c, (MTCY71.28c), len: 137 aa. usfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins." /codon_start=1 /transl_table=11 /product="PUTATIVE PROTEIN USFY" /protein_id="CAB07070.1" /db_xref="GI:1877343" /db_xref="UniProtKB/TrEMBL:Q7D5S0" /translation="MGQIPPQPVRRVLPLMVVPGNGQKWRNRTETEEAMGDTYRDPVD HLRTTRPLAGESLIDVVHWPGYLLIVAGVVGGVGALAAFGTGHHAEGMTFGVVAIVVT VVGLAWLAFEHRRIRKIADRWYTEHPEVRRQRLAG" gene complement(202371..202748) /locus_tag="Rv3289c" CDS complement(202371..202748) /locus_tag="Rv3289c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3289c, (MTCY71.29c), len: 125 aa. Possible transmembrane protein, showing slight similarity to other membrane proteins or glycoproteins." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSMEMBRANE PROTEIN" /protein_id="CAB07071.1" /db_xref="GI:1877344" /db_xref="GOA:P96894" /db_xref="UniProtKB/TrEMBL:P96894" /translation="MHEVGGPSRGDRLGRDDSEVHSAIRFAVVAAVVGVGFLIMGALL VSTCSGVDTAACGPPQRILLALGGPLILCAAGLWAFLRTYRVWRAEGTWWGWHGAGWF LLTLMVLTLCIGVPPIAGPVMAP" gene complement(202782..204131) /gene="lat" /locus_tag="Rv3290c" CDS complement(202782..204131) /gene="lat" /locus_tag="Rv3290c" /EC_number="2.6.1.36" /function="POSSIBLY INVOLVED IN L-ALPHA-AMINOADIPIC ACID (L-AAA) BIOSYNTHESIS. CATALYZES THE TRANSFER OF THE TERMINAL AMINO GROUP OF L-LYSINE OR L-ORNITHINE TO ALPHA-KETOGLUTARATE [CATALYTIC ACTIVITY: L-LYSINE + 2-OXOGLUTARATE = 2-AMINOADIPATE 6-SEMIALDEHYDE + L-GLUTAMATE]." /experiment="experimental evidence, no additional details recorded" /note="Rv3290c, (MTCY71.30), len: 449 aa. Probable lat, lysine-epsilon aminotransferase (EC 2.6.1.36), similar to Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa), FASTA scores: opt: 1702, E(): 1.1e-99, (60.35% identity in 439 aa overlap); and Q01767|Q53823|LAT_STRCL from Streptomyces clavuligerus (457 aa), FASTA scores: opt: 1676, E(): 4.9e-98, (60.15% identity in 434 aa overlap). Also some similarity to 4-AMINOBUTYRATE AMINOTRANSFERASE PROTEINS (GAMMA-AMINO-N-BUTYRATE TRANSAMINASES). BELONGS TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. COFACTOR: PYRIDOXAL PHOSPHATE." /codon_start=1 /transl_table=11 /product="PROBABLE L-LYSINE-EPSILON AMINOTRANSFERASE LAT (L-LYSINE AMINOTRANSFERASE) (LYSINE 6-AMINOTRANSFERASE)" /protein_id="CAB07072.1" /db_xref="GI:1877345" /db_xref="GOA:P63509" /db_xref="InterPro:IPR005814" /db_xref="UniProtKB/Swiss-Prot:P63509" /translation="MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGG SYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVA MARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQV LHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEAL RQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTG CGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGN LTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFS LPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT" gene complement(204182..204634) /locus_tag="Rv3291c" CDS complement(204182..204634) /locus_tag="Rv3291c" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3291c, (MTCY71.31c), len: 150 aa. Probable transcriptional regulator asnC-family, similar to other regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces coelicolor (165 aa), FASTA scores: opt: 503, E(): 9.1e-26, (50.35% identity in 143 aa overlap); Q9KYP0|SCD69.13 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 310, E(): 2.7e-13, (37.2% identity in 129 aa overlap); BAB50701|MLL3910 from Rhizobium loti (Mesorhizobium loti) (152 aa), FASTA scores: opt: 282, E(): 1.6e-11, (39.55% identity in 129 aa overlap); O87635|LRP_KLEAE from Klebsiella aerogenes (163 aa), FASTA scores: opt: 279, E(): 2.5e-11, (38.1% identity in 147 aa overlap); etc. Contains helix-turn-helix motif at aa 22-43 (+3.94 SD). COULD BELONG TO THE ASNC FAMILY OF TRANSCRIPTIONAL REGULATORS." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY)" /protein_id="CAB07073.1" /db_xref="GI:1877346" /db_xref="GOA:P96896" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR002197" /db_xref="UniProtKB/TrEMBL:P96896" /translation="MNEALDDIDRILVRELAADGRATLSELATRAGLSVSAVQSRVRR LESRGVVQGYSARINPEAVGHLLSAFVAITPLDPSQPDDAPARLEHIEEVESCYSVAG EESYVLLVRVASARALEDLLQRIRTTANVRTRSTIILNTFYSDRQHIP" gene 204665..205912 /locus_tag="Rv3292" CDS 204665..205912 /locus_tag="Rv3292" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3292, (MTCY71.32), len: 415 aa. Conserved hypothetical protein, similar to P76097|YDCJ_ECOLI|B1423 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain K12 (447 aa), FASTA scores: opt: 747, E(): 5.6e-39, (38.55% identity in 449 aa overlap); BAB35451|ECS2028 HYPOTHETICAL 51.0 KDA PROTEIN from Escherichia coli strain O157:H7 (447 aa), FASTA scores: opt: 744, E(): 8.6e-39, (38.3% identity in 449 aa overlap); AAG56352|Z2297 PROTEIN from Escherichia coli O157:H7 EDL933 (212 aa), FASTA scores: opt: 454, E(): 4.6e-21, (41.75% identity in 206 aa overlap); and similar in part with Q49664|B1308_C1_136 from Mycobacterium leprae (71 aa), FASTA scores: opt: 305, E(): 3.2e-12, (70.0% identity in 70 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB07074.1" /db_xref="GI:2143310" /db_xref="InterPro:IPR009770" /db_xref="UniProtKB/Swiss-Prot:P65065" /translation="MSRSKRLQTGQLRARFAAGLSAMYAAEVPAYGTLVEVCAQVNSD YLTRHRRAERLGSLQRVTAERHGAIRVGNPAELAAVADLFAAFGMLPVGYYDLRTAES PIPVVSTAFRPIDANELAHNPFRVFTSMLAIEDRRYFDADLRTRVQTFLARRQLFDPA LLAQARAIAADGGCDADDAPAFVAAAVAAFALSREPVEKSWYDELSRVSAVAADIAGV GSTHINHLTPRVLDIDDLYRRMTERGITMIDTIQGPPRTDGPDVLLRQTSFRALAEPR MFRDEDGTVTPGILRVRFGEVEARGVALTPRGRERYEAAMAAADPAAVWATHFPSTDA EMAAQGLAYYRGGDPSAPIVYEDFLPASAAGIFRSNLDRDSQTGDGPDDAGYNVDWLA GAIGRHIHDPYALYDALAQEERR" gene 205939..207423 /gene="pcd" /locus_tag="Rv3293" CDS 205939..207423 /gene="pcd" /locus_tag="Rv3293" /EC_number="1.5.-.-" /function="INVOLVED IN L-ALPHA-AMINOADIPIC ACID (L-AAA) BIOSYNTHESIS (IN THE SECOND STEP; THE FIRST STEP IS PROMOTED BY LAT ENZYME." /standard_name="aldB" /experiment="experimental evidence, no additional details recorded" /note="Rv3293, (MTCY71.33), len: 494 aa. Probable pcd, piperideine-6-carboxylic acid dehydrogenase (EC 1.5.-.-), highly similar to others e.g. O85725|PCD SEMIALDEHYDE DEHYDROGENASE from Streptomyces clavuligerus (512 aa), FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity in 496 aa overlap) (see Alexander & Jensen 1998); Q9I4U7|PA1027 PROBABLE ALDEHYDE DEHYDROGENASE from Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984, E(): 1.4e-107, (64.5% identity in 493 aa overlap); BAB49892|MLL2867 ALDEHYDE DEHYDROGENASE from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 1964, E(): 2e-106, (62.8% identity in 476 aa overlap); Q9A8Y1|CC1216 ALDEHYDE DEHYDROGENASE from Caulobacter crescentus (507 aa), FASTA scores: opt: 1909, E(): 3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE from Streptomyces clavuligerus (496 aa), FASTA scores: opt: 1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap); and Q9F1U8|PCD PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE from 'Flavobacterium' lutescens (510 aa), FASTA scores: opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa overlap) (see Fujii et al., 2000); etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Note that ORF Rv3290c seems to encoded the putative lat enzyme. Note that previously known as aldB." /codon_start=1 /transl_table=11 /product="PROBABLE PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE)" /protein_id="CAE55577.1" /db_xref="GI:38490349" /db_xref="GOA:Q7D5R7" /db_xref="InterPro:IPR002086" /db_xref="UniProtKB/TrEMBL:Q7D5R7" /translation="MLEACQAIGVTAALGEPGEHSLPASTPITGDVLFSIAPTTPEQA DHAIAAAAATFTAWRSTPAPVRGALVARLGELLTAHQQDLATLVTVEVGKITAEARGE VQEMIDVCQFSVGLSRQLYGRTIASERAGHRLLETWHPLGVVGVITAFNFPVAVWAWN TAVALVCGDTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLELAVRGIVF AAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDPSAPDTLVGPLIHEAAY RDMVAALERARTDGGEVIGGDRREVGSPGAYYVAPAVVRMPSQTAIVATETFAPILYV LTYDDLDEAIALNNAVPQGLSSSIFTTDLREAEHFLDQSDCGIANVNIGTSGAEIGGA FGGEKQTGGGRESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG" misc_feature 206689..206712 /gene="pcd" /locus_tag="Rv3293" /note="PS00687 Aldehyde dehydrogenases glutamic acid active site" gene complement(207523..208332) /locus_tag="Rv3294c" CDS complement(207523..208332) /locus_tag="Rv3294c" /function="UNKNOWN" /note="Rv3294c, 269 aa. Conserved hypothetical protein, similar to several conserved hypothetical proteins from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa), FASTA scores: opt: 682, E(): 3.6e-37, (44.85% identity in 243 aa overlap); O53329|Rv3179 (454 aa), FASTA scores: opt: 561, E(): 3.3e-29, (42.20% identity in 218 aa overlap); Q10849|YK08_MYCTU|Rv2008c (441 aa), FASTA scores: opt: 194, E(): 3.9e-05, (30.10% identity in 239 aa overlap). Also some similarity with proteins from other organisms. Replace previous Rv3294 on opposite strand." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAE55578.1" /db_xref="GI:38490350" /db_xref="UniProtKB/TrEMBL:Q8VJ37" /translation="MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAK ARNVDRVVKRDAADVSNLQRIADLPRLIRLLAARSASELNLSSLATDAEIPVRTLPPY LDLLETLYLIDRIPAWSTNLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAA GAIIETFVIAELRRQLGWSQQAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATL RGRDTRSISRLRDKVGARFAGGVILHTGPQAQPFGDRLAAVPIDILWSPSG" gene 208403..209068 /locus_tag="Rv3295" CDS 208403..209068 /locus_tag="Rv3295" /function="INVOLVED IN TRANSCRIPTIONAL MECHANISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3295, (MTCY71.35), len: 221 aa. Probable transcriptional regulator tetR-family, equivalent to Q9CCL4|ML0717 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (223 aa), FASTA scores: opt: 1260, E(): 7.2e-75, (85.45% identity in 220 aa overlap). Also highly similar to other streptomyces regulators e.g. Q9RD77|SCF43.11 from Streptomyces coelicolor (205 aa), FASTA scores: opt: 442, E(): 9.8e-22, (38.6% identity in 202 aa overlap); Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa), FASTA scores: opt: 215, E(): 5.9e-07, (31.85% identity in 135 aa overlap); Q9L0U5|SCD35.06 from Streptomyces coelicolor (240 aa), FASTA scores: opt: 214, E(): 7.4e-07, (28.2% identity in 156 aa overlap); etc. SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Contains potential helix-turn-helix motif at aa 33-54 (+4.42 SD)." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)" /protein_id="CAB07059.1" /db_xref="GI:1877350" /db_xref="GOA:P96900" /db_xref="InterPro:IPR001647" /db_xref="UniProtKB/TrEMBL:P96900" /translation="MATARRRLSPQDRRAELLALGAEVFGKRPYDEVRIDEIAERAGV SRALMYHYFPDKRAFFAAVVKDEADRLYAATNKAPAPGMTMFEEIRTGVLAYMAYHQQ NPEAAWAAYVGLGRSDPVLLGIDDEAKNRQMEHIMSRIAEVVSGIDRDNTLDPEVERD LRVIIHGWLAFTFELCRQRIMDPSTDAERLADACAHALLDAISRLPQIPAELADAMAT ARM" gene 209112..213653 /gene="lhr" /locus_tag="Rv3296" CDS 209112..213653 /gene="lhr" /locus_tag="Rv3296" /EC_number="3.6.1.-" /function="HAS BOTH ATPASE AND HELICASE ACTIVITIES." /note="Rv3296, (MTCY71.36), len: 1512 aa. Probable lhr, ATP-dependent helicase (EC 3.6.1.-), similar to others e.g. P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.55% identity in 1569 aa overlap); AAG56642|LHR from Escherichia coli stain O157:H7 EDL933 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.6% identity in 1561 aa overlap); O86821|SC7C7.16c from Streptomyces coelicolor (1690 aa), FASTA scores: opt: 2919, E(): 7e-159, (53.55% identity in 1703 aa overlap); Q9HYW9|PA3272 from Pseudomonas aeruginosa (1448 aa), FASTA scores: opt: 907, E(): 6.2e-44, (35.85% identity in 1512 aa overlap); etc. SIMILAR TO DEAD/DEAH BOX HELICASE FAMILY AND TO HELICASE C-TERMINAL DOMAIN. Contains PS00017 ATP/GTP-binding site motif A and possible helix-turn-helix motif." /codon_start=1 /transl_table=11 /product="PROBABLE ATP-DEPENDENT HELICASE LHR (LARGE HELICASE-RELATED PROTEIN)" /protein_id="CAB07060.1" /db_xref="GI:1877351" /db_xref="GOA:P96901" /db_xref="InterPro:IPR001410" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011545" /db_xref="UniProtKB/TrEMBL:P96901" /translation="MRFAQPSALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNT LVIAPTGSGKTLAAFLWALDSLAGSEPMSERPAATRVLYVSPLKALAVDVERNLRTPL AGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQPPDVLITTPESLFLMLTSAAR QTLTGVQTVIIDEIHAIAATKRGAHLALSLERLDDLSSRRRAQRIGLSATVRPPEELA RFLSGQSPTTIVAPPAAKTVELSVQVPVPDMANLTDNTIWPDVEARLVDLIESHNSTI VFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAPAHIMGSGQTFGAPPVLA RAHHGSISKEQRAVVEEDLKRGQLKAVVATSSLELGIDMGAVDLVIQVQAPPSVASGL QRIGRAGHQVGEISRGVLFPKHRTDLLGCAVSVQRMLAGEIETMRVPANPLDILAQHT VAAAALEPLDADAWFDTVRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYD RDTGTLTARPGAQRLAVTSGGAIPDRGLFAVYLATERPSRVGELDEEMVYESRPGDVI SLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAALGALTGELAALD RTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDSTLLVERFRDELGDWRVILH SPYGLRVHGPLALAVGRRLRDRYGIDEKPTASDNGIVVRLPDTVSAGEDSPPGAELFV FDADEIDPIVTTEVAGSALFASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEV ARKYPDFPIVLETVRECLQDVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLF GYVGAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQLQHLA ADRVARDAEGVADLLRLLGPLTEDEIAARAGAPEVSGWLDGLRAAKRALVVSFAGRSW WVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPLGELLGRYARTHTPFTTAAAAARFG LGLRVTADVLGRLASDGRLVRGEFVAAAKGSAGGEQWCDAEVLRILRRRSLAALRAQA EPVSTAAYGRFLPAWQHVSAGNSGIDGLAAVIDQLAGVRIPASAIEPLVLAPRIRDYS PAMLDELLASGDVTWSGAGSISGSDGWIALHPADSAPMTLAEPAEIDFTDAHRAILAS LGTGGAYFFRQLTHDGLTEAELKAALWELIWAGRVTGDTFAPVRAVLGGAGTRKRAAP AHGGHRPPRLSRYRLTHAQARNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGV LTKDAVAAEGVAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDRLRSYL DGVDPEQPDYHAVVLAAADPANPYGAALPWPASSADGTARPGRKAGALVVLVDGELAW FLERGGRSLLTFTDDPEANHAAAIGLADLVTAGRVASILVERADGMPVLQPGGRASAA LTALLAAGFVRTPRGLRRR" misc_feature 209253..209276 /gene="lhr" /locus_tag="Rv3296" /note="PS00017 ATP/GTP-binding site motif A" gene 213657..214424 /gene="nei" /locus_tag="Rv3297" CDS 213657..214424 /gene="nei" /locus_tag="Rv3297" /EC_number="3.2.-.-" /function="INVOLVED IN DAMAGE REVERSAL. DNA N-GLYCOSYLASE WITH AN AP LYASE ACTIVITY. REQUIRED FOR THE REPAIR OF OXIDATIVE DNA DAMAGE (OXIDIZED PYRIMIDINES)." /note="Rv3297, (MTCY71.37, MT3396), len: 255 aa. Probable nei, endonuclease VIII (EC 3.2.-.-) (see citation below), similar to others e.g. O86820|END8_STRCO|NEI|SC7C7.15c from Streptomyces coelicolor (276 aa), FASTA scores: opt: 770, E(): 1.2e-42, (50.35% identity in 268 aa overlap); P50465|END8_ECOLI|NEI|B0714 from Escherichia coli strain K12 (262 aa), FASTA scores: opt: 310, E(): 6.3e-13, (28.1% identity in 267 aa overlap); AAG55037|NEI from Escherichia coli strain O157:H7 EDL933 (263 aa), FASTA scores: opt: 301, E(): 2.4e-12, (27.7% identity in 267 aa overlap); etc. BELONGS TO THE FPG FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE ENDONUCLEASE VIII NEI" /protein_id="CAB07061.1" /db_xref="GI:1877352" /db_xref="GOA:P64156" /db_xref="UniProtKB/Swiss-Prot:P64156" /translation="MPEGDTVWHTAATLRRHLAGRTLTRCDIRVPRFAAVDLTGEVVD EVISRGKHLFIRTGTASIHSHLQMDGSWRVGNRPVRVDHRARIILEANQQEQAIRVVG VDLGLLEVIDRHNDGAVVAHLGPDLLADDWDPQRAAANLIVAPDRPIAEALLDQRVLA GIGNVYCNELCFVSGVLPTAPVSAVADPRRLVTRARDMLWVNRFRWNRCTTGDTRAGR RLWVYGRAGQGCRRCGTLIAYDTTDERVRYWCPACQR" gene complement(214447..215361) /gene="lpqC" /locus_tag="Rv3298c" CDS complement(214447..215361) /gene="lpqC" /locus_tag="Rv3298c" /EC_number="3.1.-.-" /function="UNKNOWN; LIPOLYTIC ENZYME INVOLVED IN CELLULAR METABOLISM." /note="Rv3298c, (MTCY71.38c), len: 304 aa. Possible lpqC, esterase lipoprotein (EC 3.1.-.-), equivalent to Q9CCL5|LPQC|ML0715 PUTATIVE SECRETED HYDROLASE from Mycobacterium leprae (304 aa), FASTA scores: opt: 1543, E(): 1.3e-87, (71.6% identity in 303 aa overlap); and Q49658|B1308_F2_43 TUBULIN FAMILY PROTEIN from Mycobacterium leprae (302 aa), FASTA scores: opt: 1541, E(): 1.7e-87, (72.0% identity in 300 aa overlap). Also similar to Q9I5Z3|PA0543 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (322 aa), FASTA scores: opt: 439, E(): 8.9e-20, (32.3% identity in 319 aa overlap); Q9F2K9|SCH63.19c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (348 aa), FASTA scores: opt: 394, E(): 5.5e-17, (30.25% identity in 334 aa overlap); etc. And similar to O86367|LPQP|Rv0671|MTCI376.03c from Mycobacterium tuberculosis strain H37Rv (280 aa), FASTA scores: opt: 519, E(): 9.8e-25, (39.25% identity in 275 aa overlap). Probably lipoprotein, esterase membrane-bound, with 18 aa signal sequence as it contains appropriately positioned (PS00013) Prokaryotic membrane lipoprotein lipid attachment site." /codon_start=1 /transl_table=11 /product="POSSIBLE ESTERASE LIPOPROTEIN LPQC" /protein_id="CAB07062.1" /db_xref="GI:1877354" /db_xref="GOA:P96903" /db_xref="InterPro:IPR000217" /db_xref="InterPro:IPR000379" /db_xref="UniProtKB/TrEMBL:P96903" /translation="MPWARMLSLIVLMVCLAGCGGDQLLARHASSVATFQFGGLTRSY RLHVPPAEPSGLVISLHGGGGTGAGQEALTDFDAVADAADLLVVYPDGYDKSWADGRG ASPADRRHLDDVGFLVALAAKLVHDFDIAPGHVFATGMSNGGFMSNRLACDRADIFAA VAPVAGTLGVGVTCNPSRPVSVLEAHGTADPLVPFNGGAVRGRGGLSHSISVASLVDR WRAVDGCQGDPSAAELPDVGDGTMVHLFDSSSCAAGTEVISYQIDNGGHTWPGGRQYL PKAVIGATTRAFDGSQVIAQFFATHGRD" gene complement(215388..218300) /gene="atsB" /locus_tag="Rv3299c" CDS complement(215388..218300) /gene="atsB" /locus_tag="Rv3299c" /EC_number="3.1.6.1" /function="GENERATES SULFATE AND PHENOL FROM PHENOL SULFATE [CATALYTIC ACTIVITY: A PHENOL SULFATE + H(2)O = A PHENOL + SULFATE]." /note="Rv3299c, (MTCI418A.01c, MTCY71.39c), len: 970 aa. Probable atsB, arylsulfatase (EC 3.1.6.1), similar to P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from Pseudomonas aeruginosa (535 aa), FASTA scores: opt: 645, E(): 5.8e-31, (32.0% identity in 550 aa overlap); Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa), FASTA scores: opt: 504, E(): 1.7e-22, (26.3% identity in 566 aa overlap); and P20713|ATSA|ARS_KLEAE (precursor) from Klebsiella pneumoniae (464 aa), FASTA scores: opt: 502, E(): 1.8e-22, (26.85% identity in 451 aa overlap). Also similar to Mycobacterium tuberculosis proteins O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6% identity in 796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa) (38.4% identity in 797 aa overlap). Equivalent to AAK47741 from Mycobacterium tuberculosis strain CDC1551 (992 aa) but shorter 22 aa. Contains PS00523 Sulfatases signature 1 and PS01095 Chitinases family 18 active site signature. BELONGS TO THE SULFATASE FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE ARYLSULFATASE ATSB (ARYL-SULFATE SULPHOHYDROLASE) (SULFATASE)" /protein_id="CAB09444.1" /db_xref="GI:2181956" /db_xref="GOA:O65931" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR001579" /db_xref="UniProtKB/TrEMBL:O65931" /translation="MMSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLI GKDAEGSPVLVDTGNRLGRRGAAWGAGVGLAIGLFSPALLASAALGAATGALAGTFAH HRIKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALASSPMKSVAELSRSTLRSLG AALREAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWSIVPGPFPPDDAPNVLIVL IDDAGFGGPDTFGGAIRTPTLSRLAQNGLIYNRFHVTAVCSPTRAALLTGRNHHRVGF GSVCEFPGPYPGYSAVRPRSCAALPRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNW PLGWGFDHFWGFPSGAAGQYDPIISQDNSVIGIPEGSGEDGRPYYFPDDLTDKAIEWL HTVRAQNATKPWMLYYATGATHAPHHVFKEWADKYRGEFDDGWDVYRQKTFERQKRLG IIPPDAELTERPDLFPAWDSMSEAQKRLFARQMEVFAGFSENADWNVGRLLDAIEDLG ESDNTLVFYIWGDNGASMEGTNTGSFNEMTFLNGLDLDAERQLELIEQYGGIAALGDE FTAPHFASAWAHASNTPLQWGKQMASHLGGTRDPLVVAWPARIRPDGRVRSQFTHCID IAPTVLAAIGLPEPTHVDGFEQEPMDGTSFVRTFDDAEAEDRHTVQYFENFGSRAIYK DGWWACARLDKAPWDLSPETMRRFAPGTYDPDQDVWELYYLPDDFSQAKNLAAEHPDK VAELTQLWWQEAERNRVLPLLGGLAVMFGDLPPLPTTARFSFKGDVQNIQRGMVPRIC GRSYAIEARLHIPDGGAQGVIVANADFMGGFALWVDEQRHLHHTYSFLGVETYRQVSS EPLPTGDVTVRMLFDSHQPVAASGGRVTLWADDRLIGEGELPQTVPLAFTSYAGMDIG RDNGLVVDRGYEDKAPYAFTGTVTEVIFDLKPVHPEAARALHEHASVQAVGQGAAG" misc_feature complement(216657..216683) /gene="atsB" /locus_tag="Rv3299c" /note="PS01095 Chitinases family 18 active site signature" misc_feature complement(217497..217535) /gene="atsB" /locus_tag="Rv3299c" /note="PS00523 Sulfatases signature 1" gene complement(218320..219237) /locus_tag="Rv3300c" CDS complement(218320..219237) /locus_tag="Rv3300c" /function="UNKNOWN" /note="Rv3300c, (MTCI418A.02c), len: 305 aa. Conserved hypothetical protein, similar to various proteins (notably pseudoridine synthase family proteins) e.g. Q9RJ76|SCI41.08 PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 876, E(): 4.5e-48, (52.1% identity in 313 aa overlap); Q9I272|PA2043 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa), FASTA scores: opt: 676, E(): 1.8e-35, (42.55% identity in 268 aa overlap); Q9JZW8|NMB0867 YABO/YCEC/SFHB FAMILY PROTEIN from Neisseria meningitidis (serogroup B) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q9JUY2|NMA1085 HYPOTHETICAL PROTEIN from Neisseria meningitidis (serogroup A) (307 aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa overlap); Q12362|RIB2_YEAST|RIB2|YOL066C DRAP DEAMINASE (PSEUDOURIDINE SYNTHASE FAMILY PROTEIN) from Saccharomyces cerevisiae (Baker's yeast) (591 aa), FASTA scores: opt: 338, E(): 6.9e-14, (32.95% identity in 246 aa overlap); Q9RTS2|DR1684 PUTATIVE PSEUDOURIDINE SYNTHASE from Deinococcus radiodurans (321 aa), FASTA scores: opt: 319, E(): 6.5e-13, (32.75% identity in 235 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical protein Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308 aa) (28.8% identity in 299 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB09445.1" /db_xref="GI:2181957" /db_xref="GOA:O07166" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="UniProtKB/TrEMBL:O07166" /translation="MALRPEDRLLSVHDVLGPVRVRLLGGSVLAELTARFGVAARAKV LAGEVVDDDGAVVDSGTVLPPGSVVHLYRDLPDEVPVPFDVPVLHQDADIVVVDKPHF LATMPRGRHVAQTALVRLRRELGLPELSPAHRLDRLTAGVLLFTTRREVRGSYQTMFA RGLVRKTYLARAPVAPGLALPRLVRSRIVKRRGHLQAVCEPGVPNAETLVERIARDGL YRLTPTTGRTHQLRVHMAALGIPIMGDPLYPNVISVAAHDFSTPLQLLAQRIEFDDPL TGSHREFASTRTLTGATLPTWSAAADCRP" gene complement(219249..219914) /gene="phoY1" /locus_tag="Rv3301c" CDS complement(219249..219914) /gene="phoY1" /locus_tag="Rv3301c" /function="INVOLVED IN TRANSCRIPTIONAL REGULATION OF ACTIVE TRANSPORT OF INORGANIC PHOSPHATE ACROSS THE MEMBRANE." /note="Rv3301c, (MTCI418A.03c), len: 221 aa. Probable phoY1, phosphate-transport system regulatory protein, highly similar to Q50047|phoY|PHOU1|PHOY1|ML2188 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 1 from Mycobacterium leprae (222 aa), FASTA scores: opt: 929, E(): 7.8e-51, (61.45% identity in 218 aa overlap). Also highly similar to Q9FCE2|2SCD46.42c PUTATIVE REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (123 aa), FASTA scores: opt: 324, E(): 1.8e-13, (43.65% identity in 103 aa overlap); Q9L0R3|SCD8A.01c PUTATIVE PHOSPHATE TRANSPORT SYSTEM REGULATORY PROTEIN (FRAGMENT) from Streptomyces coelicolor (139 aa), FASTA scores: opt: 309, E(): 1.7e-12, (36.7% identity in 139 aa overlap); Q52989|PHOU_RHIME PHOSPHATE TRANSPORT SYSTEM PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (237 aa), FASTA scores: opt: 292, E(): 3.1e-11, (26.3% identity in 213 aa overlap); etc. And highly similar to Mycobacterium tuberculosis O53833|PHU2_MYCTU|MTV043_13c|PHOU2|PHOY2|Rv0821c|MT0843 PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (213 aa) (63.4% identity in 213 aa overlap). BELONGS TO THE PHOU FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE PHOSPHATE-TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PHOU HOMOLOG 1 PHOY1" /protein_id="CAB09446.1" /db_xref="GI:2181958" /db_xref="GOA:P65718" /db_xref="InterPro:IPR008170" /db_xref="UniProtKB/Swiss-Prot:P65718" /translation="MRTVYHQRLTELAGRLGEMCSLAGIAMKRATQALLEADIGAAEQ VIRDHERIVAMRAQVEKEAFALLALQHPVAGELREIFSAVQIIADTERMGALAVHIAK ITRREYPNQVLPEEVRNCFADMAKVAIALGDSARQVLVNRDPQEAAQLHDRDDAMDDL HRHLLSVLIDREWRHGVRVGVETALLGRFFERFADHAVEVGRRVIFMVTGVLPTEDEI STY" gene complement(220022..221779) /gene="glpD2" /locus_tag="Rv3302c" CDS complement(220022..221779) /gene="glpD2" /locus_tag="Rv3302c" /EC_number="1.1.99.5" /function="INVOLVED IN AEROBIC RESPIRATION AND OXYDATION OF GLYCEROL. REDUCES AN ACCEPTOR AND GENERATES GLYCERONE PHOSPHATE FROM Sn-GLYCEROL 3-PHOSPHATE. POSSIBLY PLAY A ROLE IN METABOLISM OF RIBOFLAVIN, FAD,FMN [CATALYTIC ACTIVITY: SN-GLYCEROL 3-PHOSPHATE + ACCEPTOR = GLYCERONE PHOSPHATE + REDUCED ACCEPTOR]." /note="Rv3302c, (MTCI418A.04c, MTV016.01c), len: 585 aa. Probable glpd2, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), equivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 GLYCEROL-3-PHOSPHATE DEHYDROGENASE (EC 1.1.99.5) from Mycobacterium leprae (585 aa), FASTA scores: opt: 3489, E(): 2.2e-198, (90.75% identity in 584 aa overlap). Also highly similar to many e.g. Q9L0I3|SCD63.06 from Streptomyces coelicolor (568 aa), FASTA scores: opt: 2203, E(): 1.6e-122, (59.95% identity in 564 aa overlap); Q9RVK8|DR1019 from Deinococcus radiodurans (522 aa), FASTA scores: opt: 949, E(): 1.4e-48, (37.0% identity in 538 aa overlap); BAB53412|MLR7270 from Rhizobium loti (Mesorhizobium loti) (505 aa), FASTA scores: opt: 861, E(): 2.2e-43, (37.3% identity in 488 aa overlap); P18158|GLPD_BACSU from B. subtilis (555 aa), FASTA scores: opt: 768, E(): 7.2e-38, (32.85% identity in 484 aa overlap); etc. Also similar to Mycobacterium tuberculosis protein Q10502|GLPD_MYCTU|MTCY427_31c|Rv2249c GLYCEROL-3-PHOSPHATE DEHYDROGENASE (516 aa), FASTA scores: opt: 843, E(): 2.6e-42, (36.5% identity in 515 aa overlap). Contains PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. COFACTOR: FAD (BY SIMILARITY). BELONGS TO THE FAD-DEPENDENT GLYCEROL-3-PHOSPHATE DEHYDROGENASE FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLPD2" /protein_id="CAB09447.1" /db_xref="GI:3261792" /db_xref="GOA:P64184" /db_xref="InterPro:IPR000205" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR006076" /db_xref="UniProtKB/Swiss-Prot:P64184" /translation="MSNPIQAPDGGQGWPAAALGPAQRAVAWKRLGTEQFDVVVIGGG VVGSGCALDAATRGLKVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALYE RELSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLGGAKSVPAQRHFTRAG ALRLSPGLKRSSLIGGIRYYDTVVDDARHTMTVARTAAHYGAVVRCSTQVVALLREGD RVIGVGVRDSENGAVAEVRGHVVVNATGVWTDEIQALSKQRGRFQVRASKGVHVVVPR DRIVSDVAMILRTEKSVMFVIPWGSHWIIGTTDTDWNLDLAHPAATKADIDYILGTVN AVLATPLTHADIDGVYAGLRPLLAGESDDTSKLSREHAVAVPAAGLVAIAGGKYTTYR VMAADAIDAAVQFIPARVAPSITEKVSLLGADGYFALVNQAEHVGALQGLHPYRVRHL LDRYGSLISDVLAMAASDPSLLSPITEAPGYLKVEAAYAAAAEGALHLEDILARRMRI SIEYPHRGVDCAREVAEVVAPVLGWTAADIDREVANYMARVEAEVLSQAQPDDVSADM LRASAPEARAEILEPVPLD" misc_feature complement(220595..220627) /gene="glpD2" /locus_tag="Rv3302c" /note="PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2" gene complement(221794..223275) /gene="lpdA" /locus_tag="Rv3303c" CDS complement(221794..223275) /gene="lpdA" /locus_tag="Rv3303c" /EC_number="1.8.1.4" /function="INVOLVED IN ENERGY METABOLISM. LIPOAMIDE DEHYDROGENASE IS GENERALLY A COMPONENT OF THE MULTIENZYME PYRUVATE DEHYDROGENASE AND/OR ALPHA-KETOACID DEHYDROGENASE AND/OR 2-OXOGLUTARATE DEHYDROGENASE COMPLEXES [CATALYTIC ACTIVITY: DIHYDROLIPOAMIDE + NAD(+) = LIPOAMIDE + NADH]." /note="Rv3303c, (MTV016.02c), len: 493 aa. Probable lpdA, dihydrolipoamide dehydrogenase (EC 1.8.1.4), similar to other e.g. Q9EWV3|2SCK31.22c PUTATIVE OXIDOREDUCTASE from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1420, E(): 2.4e-77, (54.9% identity in 471 aa overlap); Q9A7J2|CC1731 LIPOAMIDE DEHYDROGENASE (E3 COMPONENT,PYRUVATE DEHYDROGENASE COMPLEX) from Caulobacter crescentus (466 aa), FASTA scores: opt: 696, E(): 3.6e-34, (29.6% identity in 463 aa overlap); Q04829|LPD|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE from Halobacterium volcanii (Haloferax volcanii) (474 aa), FASTA scores: opt: 675, E(): 6.5e-33, (29.3% identity in 471 aa overlap); P50970|DLDH_ZYMMO|LPD DIHYDROLIPOAMIDE DEHYDROGENASE from Zymomonas mobilis, FASTA scores: opt: 658, E(): 6.6e-32, (30.4% identity in 464 aa overlap); etc. BELONGS TO THE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASES CLASS-I. COFACTOR: FAD (BY SIMILARITY). TBparse score is 0.883." /codon_start=1 /transl_table=11 /product="PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE)" /protein_id="CAA17075.1" /db_xref="GI:2894212" /db_xref="GOA:O53355" /db_xref="InterPro:IPR000815" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR001327" /db_xref="InterPro:IPR004099" /db_xref="UniProtKB/TrEMBL:O53355" /translation="MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAV LDDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADIT AQLLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILP SAQPDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVL PYEDADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIG SVPNTSGLGLERVGIQLGRGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRI AMYHALGEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARA KMSEMRHGFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVY PSLSGSITEAARRLMAHDDLDCTAAQDAAEQLALVPHHLPTSN" gene 223478..223957 /locus_tag="Rv3304" CDS 223478..223957 /locus_tag="Rv3304" /function="UNKNOWN" /note="Rv3304, (MTV016.03), len: 159 aa. Hypothetical conserved protein, very similar to Q9CCL6|ML0711 HYPOTHETICAL PROTEIN from Mycobacterium leprae (159 aa), FASTA scores: opt: 1041, E(): 6.1e-62, (91.8% identity in 159 aa overlap); and Q49927|L308_F3_97 from M. leprae (174 aa), FASTA scores: opt: 974, E(): 1.8e-57, (91.2% identity in 149 aa overlap) . Also highly similar to Q9AD81|SCK13.10c CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (145 aa), FASTA scores: opt: 615, E(): 7.8e-34, (60.55% identity in 147 aa overlap); and shows some similarity to other various hypotheticals proteins. ORF continues upstream with possible start at 2198 (equivalent to AAK47746 from Mycobacterium tuberculosis strain CDC1551 (212 aa) but shorter 53 aa). TBparse score is 0.922." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17076.1" /db_xref="GI:2894213" /db_xref="UniProtKB/TrEMBL:O53356" /translation="MPLYAAYGSNMHPEQMLERAPHSPMAGTGWLPGWRLTFGGEDIG WEGALATVVEDPDSKVFVVLYDMTPADEKNLDRWEGSEFGIHQKIRCRVERISSDTTT DPVLAWLYVLDAWEGGLPSARYLGVMADAAEIAGAPSDYVHDLRTRPARNIGPGTIA" gene complement(223976..225145) /gene="amiA1" /locus_tag="Rv3305c" CDS complement(223976..225145) /gene="amiA1" /locus_tag="Rv3305c" /EC_number="3.5.1.-" /function="UNKNOWN; CERTAINLY HYDROLYSES L-AMINO ACID." /standard_name="amiA" /note="Rv3305c, (MTV016.04c), len: 389 aa. Possible amiA1, N-acyl-L-amino acid amidohydrolase (or peptidase) (EC 3.5.1.-), similar to many proteins e.g. Q9AK43|2SCK8.09 PUTATIVE PEPTIDASE from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1015, E(): 3.9e-54, (50.8% identity in 374 aa overlap); Q9UZ30|PAB0873 AMINO ACID AMIDOHYDROLASE from Pyrococcus abyssi (383 aa), FASTA scores: opt: 823, E(): 1.6e-42, (38.2% identity in 369 aa overlap); O58453|PH0722 LONG HYPOTHETICAL AMINO ACID AMIDOHYDROLASE from Pyrococcus horikoshii (388 aa), FASTA scores: opt: 815, E(): 4.8e-42, (38.75% identity in 369 aa overlap); O34980|YTNL_BACSU HYPOTHETICAL 45.2 KDA PROTEIN from B. subtilis (416 aa), FASTA scores: opt: 805, E(): 2.1e-41, (37.85% identity in 367 aa overlap); Q9KCF8|BH1613 N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Bacillus halodurans (404 aa), FASTA scores: opt: 795, E(): 8.1e-41, (37.7% identity in 382 aa overlap); BAB50445|MLR3583 HYPOTHETICAL HIPPURATE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (387 aa), FASTA scores: opt: 761, E(): 8.9e-39, (37.65% identity in 385 aa overlap); Q9RXH4|DR0339 PUTATIVE N-ACYL-L-AMINO ACID AMIDOHYDROLASE from Deinococcus radiodurans (392 aa), FASTA scores: opt: 745, E(): 8.4e-38, (36.15% identity in 379 aa overlap); etc. Contains PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. TBparse score is 0.905. Note that previously known as amiA." /codon_start=1 /transl_table=11 /product="POSSIBLE N-ACYL-L-AMINO ACID AMIDOHYDROLASE AMIA1 (N-ACYL-L-AMINO ACID AMINOHYDROLASE)" /protein_id="CAE55579.1" /db_xref="GI:38490351" /db_xref="GOA:Q7D5R0" /db_xref="InterPro:IPR000169" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010168" /db_xref="UniProtKB/TrEMBL:Q7D5R0" /translation="MSLADAAESWLAAHHDDLVGWRRHIHRYPELGRQEYATTQFVAE RLADAGLNPKVLPGGTGLTCDFGPQHQPRIALRADMDALPMAERTGAPYASTMPNVAH ACGHDAHTAILLGAALALASVPELPVGVRLIFQAAEELMPGGAIDAIAAGALAGVSRI FALHCDPRLEVGKVAVRQGPITSAADSIEITLYSPGGHTSRPHLTADLVYGLGTLVTG LPGVLSRRIDPRNSTVLVWGAVNAGMAANAIPQTGVLSGTVRTASRQTWVDLEELVRQ AISALLLPLAIEHTLQYRRGVPPVVNEEISTRILAHAIEAIGPGVLADTRQSGGGEDF SWYLEEVPGAMARLGVWSGDGLQLDLHQPTFDIDERALAIGLRVMVNIIEQAAAH" misc_feature complement(224186..224218) /gene="amiA1" /locus_tag="Rv3305c" /note="PS00639 Eukaryotic thiol (cysteine) proteases histidine active site" gene complement(225142..226326) /gene="amiB1" /locus_tag="Rv3306c" CDS complement(225142..226326) /gene="amiB1" /locus_tag="Rv3306c" /EC_number="3.5.1.-" /function="INVOLVED IN CELLULAR METABOLISM, ACTIVE ON CARBON ALIPHATIC AMIDES AND/OR ON MANY AROMATIC AMIDES [CATALYTIC ACTIVITY : A MONOCARBOXYLIC ACID AMIDE + H(2)O = A MONOCARBOXYLATE + NH(3)]." /standard_name="amiB" /note="Rv3306c, (MTV016.05c), len: 394 aa. Probable amiB1, aminohydrolase (EC 3.5.1.-), similar to several belonging to peptidase family M40 (and to hypothetical proteins) e.g. P54983|AMHX_BACSU AMIDOHYDROLASE AMHX from Bacillus subtilis (EC 3.5.1.-) (389 aa), FASTA scores: opt: 286, E(): 9.9e-10, (26.6% identity in 351 aa overlap); P76052|ABGB_ECOLI Aminobenzoyl-glutamate utilizatio from Escherichia coli (481 aa), FASTA scores: opt: 383, E(): 2.1e-15, (30.5% identity in 328 aa overlap); P44765|YDAJ_HAEIN HYPOTHETICAL PROTEIN HI0584 from Haemophilus influenzae (423 aa), FASTA scores: opt: 297, E(): 2.4e-10, (29.6% identity in 274 aa overlap). TBparse score is 0.897. Note that previously known as amiB." /codon_start=1 /transl_table=11 /product="PROBABLE AMIDOHYDROLASE AMIB1 (AMINOHYDROLASE)" /protein_id="CAE55580.1" /db_xref="GI:38490352" /db_xref="GOA:Q7D5Q9" /db_xref="InterPro:IPR010168" /db_xref="InterPro:IPR011650" /db_xref="UniProtKB/TrEMBL:Q7D5Q9" /translation="MPAASASDRVEELVRRRGGELVELSHAIHAEPELAFAEHRSCAK AQALVAERGFEITTAAGGLDTAFRADYGSGPLVVGVCAEYDALPGIGHACGHNIIAAS AVGTALALAEVADDLGLTVALLGTPAEESGGGKALMLQAGTFDDVAVAVMVHPGPTDI AGARSLALSEVTVRYRGKESHAAVAPHLGVNAADAVTVAQVAIGVLRQQLAPGQMVHG IVTDGGQAVNVIPGQARLQYAMRAVESDSLRELQTRMFACFAAGALAAGCEYEIDEAA PAYAELKPDPWLADVCREEMQRLGREPLLPALEAELPLGSTDMGNVTQVLPGIHPVIG LDAGAATVHQRAFTVASAGASADRAVVDGAIMLARTVVRLAQTPDERDRVLAAQQRRA AR" gene 226391..227197 /gene="deoD" /locus_tag="Rv3307" CDS 226391..227197 /gene="deoD" /locus_tag="Rv3307" /EC_number="2.4.2.1" /function="INVOLVED IN PURINE NUCLEOSIDE SALVAGE. CLEAVAGE OF GUANOSINE OR INOSINE TO RESPECTIVE BASES AND SUGAR-1-PHOSPHATE MOLECULES [CATALYTIC ACTIVITY: PURINE NUCLEOSIDE + ORTHOPHOSPHATE = PURINE + ALPHA-D-RIBOSE 1-PHOSPHATE]." /standard_name="punA" /note="Rv3307, (MTV016.06), len: 268 aa. Probable deoD (alternate gene name: punA), purine nucleoside phosphorylase (EC 2.4.2.1), similar to others especially P46862|PUNA_MYCLE|DEOD_MYCLE|ML0707|L308_F2_56 from M. leprae (268 aa), FASTA scores: opt: 1373, E(): 1.5e-74, (82.05% identity in 262 aa overlap); Q9EWV2|2SCK31.24 from Streptomyces coelicolor (274 aa), FASTA scores: opt: 1026, E(): 6.4e-54, (60.5% identity in 266 aa overlap); P81989|PUNA_CELSP from Cellulomonas sp (282 aa), FASTA scores: opt: 963, E(): 3.6e-50, (58.9% identity in 270 aa overlap); Q9X1T2|TM1596 from Thermotoga maritima (265 aa), FASTA scores: opt: 584, E(): 1.1e-27, (39.55% identity in 263 aa overlap); etc. BELONGS TO THE PNP/MTAP FAMILY 2 OF PHOSPHORYLASES. TBparse score is 0.878." /codon_start=1 /transl_table=11 /product="PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE DEOD (INOSINE PHOSPHORYLASE) (PNP)" /protein_id="CAA17079.1" /db_xref="GI:2894216" /db_xref="GOA:P0A538" /db_xref="InterPro:IPR001369" /db_xref="UniProtKB/Swiss-Prot:P0A538" /translation="MADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAA LGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVH PVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAY SPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARA AGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF" gene 227201..228805 /gene="pmmB" /locus_tag="Rv3308" CDS 227201..228805 /gene="pmmB" /locus_tag="Rv3308" /EC_number="5.4.2.8" /function="CONVERTES D-MANNOSE 1-PHOSPHATE TO D-MANNOSE 6-PHOSPHATE." /note="Rv3308, (MTV016.07), len: 534 aa. Probable pmmB, phosphomannomutase (EC 5.4.2.8), equivalent to Q9CCL7|PMMB|ML0706 PUTATIVE PHOSPHO-SUGAR MUTASE from Mycobacterium leprae (538 aa), FASTA scores: opt: 2681, E(): 1.4e-150, (76.95% identity in 538 aa overlap). Also similar to others e.g. Q9AD82|SCK13.08c from Streptomyces coelicolor (549 aa), FASTA scores: opt: 1378, E(): 8.9e-74, (46.7% identity in 529 aa overlap); Q9ZHL4|PMM (FRAGMENT so no homology at N-terminus for this one) from Haemophilus ducreyi (443 aa), FASTA scores: opt: 935, E(): 9.6e-48, (39.4% identity in 449 aa overlap); P18159|YHXB_BACSU from Bacillus subtilis (565 aa), FASTA scores: opt: 776, E(): 2.7e-38, (31.7% identity in 574 aa overlap); etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. TBparse score is 0.898." /codon_start=1 /transl_table=11 /product="PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE)" /protein_id="CAA17080.1" /db_xref="GI:2894217" /db_xref="GOA:O53360" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="UniProtKB/TrEMBL:O53360" /translation="MTPENWIAHDPDPQTAAELAACGPDELKARFSRPLAFGTAGLRG HLRGGPDAMNLAVVLRATWAVARVLTDRGLAGSPVIVGRDARHGSPAFAAAAAEVLAA AGFSVLLLPDPAPTPVVAFAVRHTGAAAGIQITASHNPATDNGYKVYVDGGLQLLAPT DRQIEAAMATAPPADQIARKTVNPSENRASDLIDRYIQRAAGVRRCAGSVRVALTPLH GVGGAMAVETLRRAGFTEVHTVATQFAPNPDFPTVTLPNPEEPGATDALLTLATDVDA DVAIALDPDADRCAVGIPTVSGWRMLSGDETGWLLGDYILSQTDDRASPPETRVVAST VVSSRMLAAIAAHHAAVHVETLTGFKWLARADANLPGTLVYAYEEAIGHCVDPTAVRD KDGISAAVLVCDLVAALKGQGRSVTDALDELARCYGVHEVAALSRPVSGAVETTDLMR RLREDPPRRLAGFPATVTDIGDTLILTGGDDNMLVRVAVRPSGTEPKLKCYLEIRCAV TGDLPAARQLVRARIDELSASVRRWW" misc_feature 227591..227635 /gene="pmmB" /locus_tag="Rv3308" /note="PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature" gene complement(228807..229430) /gene="upp" /locus_tag="Rv3309c" CDS complement(228807..229430) /gene="upp" /locus_tag="Rv3309c" /EC_number="2.4.2.9" /function="INVOLVED IN PYRIMIDINE SALVAGE PATHWAY [CATALYTIC ACTIVITY: UMP + PYROPHOSPHATE = URACIL + 5-PHOSPHO-ALPHA-D-RIBOSE 1-DIPHOSPHATE]." /note="Rv3309c, (MTV016.08c), len: 207 aa. Probable upp, uracil phosphoribosyltransferase (EC 2.4.2.9), identical to P94928|UPP uracil phosphoribosyltransferase from Mycobacterium bovis (207 aa). Also similar to others e.g. P36399|UPP_STRSL from Streptococcus salivarius (209 aa), FASTA scores: opt: 658, E(): 4.7e-35, (48.3% identity in 207 aa overlap); Q9A194|UPP|SPY0392 from Streptococcus pyogenes (209 aa), FASTA scores: opt:650, E(): 1.5e-34, (47.35% identity in 207 aa overlap); Q9RE01|UPP from Lactobacillus plantarum (209 aa), FASTA scores: opt: 644, E(): 3.7e-34, (46.4% identity in 207 aa overlap); etc. BELONGS TO THE UPRTASE FAMILY. TBparse score is 0.891." /codon_start=1 /transl_table=11 /product="PROBABLE URACIL PHOSPHORIBOSYLTRANSFERASE UPP (UMP PYROPHOSPHORYLASE) (UPRTASE) (UMP DIPHOSPHORYLASE)" /protein_id="CAA17081.1" /db_xref="GI:2894218" /db_xref="GOA:P0A658" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="UniProtKB/Swiss-Prot:P0A658" /translation="MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEAT RDAPCEPVPIRTPLAETVGSRLTKPPLLVPVLRAGLGMVDEAHAALPEAHVGFVGVAR DEQTHQPVPYLDSLPDDLTDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVA APEGIAALQKAAPNVRLFTAAIDEGLNEVAYIVPGLGDAGDRQFGPR" gene 229535..230434 /locus_tag="Rv3310" CDS 229535..230434 /locus_tag="Rv3310" /EC_number="3.1.3.2" /function="INVOLVED IN CELLULAR METABOLISM: ACTING ON ESTER BONDS [CATALYTIC ACTIVITY: AN ORTHOPHOSPHORIC MONOESTER + H(2)O = AN ALCOHOL + ORTHOPHOSPHATE]." /note="Rv3310, (MTV016.09), len: 299 aa. Possible acid phosphatase (EC 3.1.3.2), similar to several fungal or bacterial acid phosphatases e.g. BAB50846|MLR4110 from Rhizobium loti (Mesorhizobium loti) (292 aa), FASTA scores: opt: 460, E(): 4.8e-22, (38.65% identity in 295 aa overlap); P34724|PHOA_ASPNG from Aspergillus niger (417 aa), FASTA scores: opt: 172, E(): 0.0013, (29.1% identity in 306 aa overlap); P08540|PHOX_KLULA from Kluyveromyces lactis (Yeast) (421 aa), FASTA scores: opt: 170, E(): 0.0018, (27.8% identity in 266 aa overlap); P37274|PHOA_PENCH from Penicillium chrysogenum (412 aa), FASTA scores: opt: 163, E(): 0.0049, (29.05% identity in 303 aa overlap); etc. TBparse score is 0.914." /codon_start=1 /transl_table=11 /product="POSSIBLE ACID PHOSPHATASE (ACID PHOSPHOMONOESTERASE) (PHOSPHOMONOESTERASE) (GLYCEROPHOSPHATASE)" /protein_id="CAA17082.1" /db_xref="GI:2894219" /db_xref="GOA:O53361" /db_xref="InterPro:IPR007312" /db_xref="UniProtKB/TrEMBL:O53361" /translation="MLRGIQALSRPLTRVYRALAVIGVLAASLLASWVGAVPQVGLAA SALPTFAHVVIVVEENRSQAAIIGNKSAPFINSLAANGAMMAQAFAETHPSEPNYLAL FAGNTFGLTKNTCPVNGGALPNLGSELLSAGYTFMGFAEDLPAVGSTVCSAGKYARKH VPWVNFSNVPTTLSVPFSAFPKPQNYPGLPTVSFVIPNADNDMHDGSIAQGDAWLNRH LSAYANWAKTNNSLLVVTWDEDDGSSRNQIPTVFYGAHVRPGTYNETISHYNVLSTLE QIYGLPKTGYATNAPPITDIWGD" gene 230458..231720 /locus_tag="Rv3311" CDS 230458..231720 /locus_tag="Rv3311" /function="UNKNOWN" /note="Rv3311, (MTV016.10), len: 420 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical proteins Q9CCL8|ML0703 (423 aa), FASTA scores: opt: 2185, E(): 5.5e-120, (77.55% identity in 423 aa overlap); Q49918|L308_F2_61 (167 aa), FASTA scores: opt: 929, E(): 3.5e-47, (84.4% identity in 167 aa overlap) (similarity at C-terminus for this one); and Q49914|L308_F1_17 (166 aa), FASTA scores: opt: 900, E(): 1.7e-45, (79.0% identity in 162 aa overlap) (similarity at N-terminus for this one); Q49923|U0308N (86 aa) FASTA scores: opt: 149, E(): 0.052, (48.35% identity in 60 aa overlap); etc. Note that the Rv3311 corresponding protein in Mycobacterium leprae is similar to products of two adjacent ORFs. Also some similarity to Q9XI61|F9L1.1 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (523 aa), FASTA scores: opt: 134, E(): 1.8, (25.1% identity in 203 aa overlap). Equivalent to AAK47753 from Mycobacterium tuberculosis strain CDC1551 (431 aa) but shorter 12 aa. TBparse score is 0.888." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17083.1" /db_xref="GI:2894220" /db_xref="UniProtKB/TrEMBL:O53362" /translation="MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYG FESVSDLVAFVRTDTENDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPT AESVAALAASLAIVSAIGSVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSI AEVIGRSWDDVLAAIDEIISTPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQE AAESDDEEADAPGDSVVLGGDRDFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGR NGRISVFGSERALARYLADEHDHDLSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGL VDDFADGPDAVDREQLDLAVELLRDIGDYSEDSAVDKALETTRPLGQLVAYVLDPHSV GKPTAPYAAAVREWEKLERFVESRLRRE" gene complement(231741..232667) /locus_tag="Rv3312c" CDS complement(231741..232667) /locus_tag="Rv3312c" /function="UNKNOWN" /note="Rv3312c, (MTV016.11), len: 308 aa. Hypothetical protein, similar to various proteins (principally hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (326 aa), FASTA scores: opt: 261, E(): 2.6e-09, (27.55% identity in 323 aa overlap); Q9FWB6 PUTATIVE ALPHA/BETA HYDROLASE from Oryza sativa (Rice) (354 aa), FASTA scores: opt: 241, E(): 4.9e-08, (28.9% identity in 301 aa overlap) (note that Q9FWB6 correspond to Q9FWB5 PUTATIVE ALPHA/BETA HYDROLASE (353 aa) but longer 1 aa; and to Q9AUW9 HYPOTHETICAL PROTEIN (332 aa) but longer 22 aa); Q9M382|F24B22.200 HYPOTHETICAL PROTEIN from Arabidopsis thaliana (Mouse-ear cress) (342 aa), FASTA scores: opt: 222, E(): 8e-07, (27.6% identity in 319 aa overlap); Q9HWM9|PA4152 PROBABLE HYDROLASE from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 176, E(): 0.00071, (29.2% identity in 209 aa overlap); Q9L3R2 HYDROLASE from Rhizobium leguminosarum (261 aa), FASTA scores: opt: 174, E(): 0.00071, (28.9% identity in 173 aa overlap); P49323|PRXC_STRLI|CPO|CPOL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) from Streptomyces lividans (275 aa), FASTA scores: opt: 172, E(): 0.001, (30.9% identity in 194 aa overlap) (similarity only at N-terminus for this one); etc. Some similarity in N-terminal part to non-heme chloroperoxidases. Also similar to O05293|Rv1191|MTCI364.03 HYPOTHETICAL PROTEIN from M. tuberculosis (304 aa), FASTA scores: opt: 417, E(): 3.1e-19, (32.6% identity in 279 aa overlap) (note that Rv1191 is equivalent to AAK45485 from Mycobacterium tuberculosis strain CDC1551 but shorter 14 aa, and that AAK45485 is annoted Hydrolase, alpha/beta hydrolase family). TBparse score is 0.922." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17084.1" /db_xref="GI:2894221" /db_xref="GOA:O53363" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000379" /db_xref="UniProtKB/TrEMBL:O53363" /translation="MTGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFYF HGTPSSRLEGAFADGAARRTGFRLIAIDRPGYGRSTFQAGRNFRDWPADVCALADAFE LEEFGVVGHSGAGPHLFACGAVIPRTRLAFVGALGPWGPLATPDIMRSLNAADRCYAR LARSGPRLFGALFAPLGWCAKYTPGLFSTLLAAAVPAADKHLLSDERFGRHLRAIQLE AFRQGSRGAAYESFLQFRPWGFDLAEVAVPTHIWLGDRDSFVPRAMGEYLQRAIPHVD LHWAHGKGHFNIEDWDAILAACALDIGKRRGG" gene complement(233042..233353) /locus_tag="Rv3312A" CDS complement(233042..233353) /locus_tag="Rv3312A" /function="UNKNOWN" /note="Rv3312A, len: 103 aa. Secreted protein antigen, described in Corixa patent as having N-terminal sequence YYWCPGQPFDPAWGP. Equivalent to AAK47756 from Mycobacterium tuberculosis strain CDC1551 (114 aa) but shorter 11 aa." /codon_start=1 /transl_table=11 /product="SECRETED PROTEIN ANTIGEN" /protein_id="CAE55581.1" /db_xref="GI:38490353" /db_xref="UniProtKB/TrEMBL:Q6MWY5" /translation="MYRFACRTLMLAACILATGVAGLGVGAQSAAQTAPVPDYYWCPG QPFDPAWGPNWDPYTCHDDFHRDSDGPDHSRDYPGPILEGPVLDDPGAAPPPPAAGGG A" gene complement(233424..234521) /gene="add" /locus_tag="Rv3313c" CDS complement(233424..234521) /gene="add" /locus_tag="Rv3313c" /EC_number="3.5.4.4" /function="CATALYZES HYDROLYTIC DEAMINATION OF ADENOSINE AND GENERATES INOSINE [CATALYTIC ACTIVITY: ADENOSINE + H(2)O = INOSINE + NH(3) (ALSO MAY ACT ON DEOXYADENOSINE)]." /note="Rv3313c, (MTV016.13), len: 365 aa. Probable add, adenosine deaminase (EC 3.5.4.4), equivalent to Q9CCL9|ADD|ML0700 PUTATIVE ADENOSINE DEAMINASE from Mycobacterium leprae (362 aa), FASTA scores: opt: 2097, E(): 1.4e-127, (88.2% identity in 356 aa overlap) . Also similar to many e.g. Q9AK25|2SCK8.27 from Streptomyces coelicolor (396 aa), FASTA scores: opt: 1578, E(): 3.7e-94, (66.65% identity in 360 aa overlap); Q17747|C06G3.5 from Caenorhabditis elegans (349 aa), FASTA scores: opt: 435, E(): 1.1e-20, (29.6% identity in 348 aa overlap); P22333|ADD_ECOLI|B1623 from Escherichia coli strain K12 (333 aa), FASTA scores: opt: 380, E(): 3.7e-17, (29.4% identity in 340 aa overlap); etc. BELONGS TO THE ADENOSINE AND AMP DEAMINASES FAMILY. TBparse score is 0.897." /codon_start=1 /transl_table=11 /product="PROBABLE ADENOSINE DEAMINASE ADD (ADENOSINE AMINOHYDROLASE)" /protein_id="CAA17085.1" /db_xref="GI:2894223" /db_xref="GOA:P63907" /db_xref="InterPro:IPR001365" /db_xref="InterPro:IPR006330" /db_xref="InterPro:IPR006650" /db_xref="UniProtKB/Swiss-Prot:P63907" /translation="MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLP ATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVY AEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSR EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSI HEAIAFCGADRLGHGVRIVDDIDVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGA VASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNA MKSAFIPFDQRLAIIDEVIKPRFAALMGHSE" gene complement(234521..235804) /gene="deoA" /locus_tag="Rv3314c" CDS complement(234521..235804) /gene="deoA" /locus_tag="Rv3314c" /EC_number="2.4.2.4" /function="THE ENZYMES WHICH CATALYZE THE REVERSIBLE PHOSPHORYLOSIS OF PYRIMIDINE NUCLEOSIDES ARE INVOLVED IN THE DEGRADATION OF THESE COMPOUNDS AND IN THEIR UTILIZATION AS CARBON AND ENERGY SOURCES, OR IN THE RESCUE OF PYRIMIDINE BASES FOR NUCLEOTIDE SYNTHESIS [CATALYTIC ACTIVITY: THYMIDINE + PHOSPHATE = THYMINE + 2-DEOXY-D-RIBOSE 1-PHOSPHATE]." /note="Rv3314c, (MTV016.14), len: 427 aa. Probable deoA, thymidine phosporylase (EC 2.4.2.4), highly similar to many e.g. Q9AK36|DEOA from Streptomyces coelicolor (427 aa), FASTA scores: opt: 1668, E(): 3.2e-90, (62.35% identity in 425 aa overlap); Q9CFM5|PDP from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (430 aa), FASTA scores: opt: 1031, E(): 5.5e-53, (46.45% identity in 392 aa overlap); P19971|TYPH_HUMAN|ECGF1 from Homo sapiens (Human) (482 aa), FASTA scores: opt: 957, E(): 1.3e-48, (44.45% identity in 441 aa overlap); P07650|TYPH_ECOLI|DEOA|TPP|TTG|B4382 from Escherichia coli strain K12 (440 aa), FASTA scores: opt: 847, E(): 3.2e-42, (41.55% identity in 438 aa overlap); etc. Contains PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. BELONGS TO THE THYMIDINE/PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASES FAMILY. TBparse score is 0.890." /codon_start=1 /transl_table=11 /product="PROBABLE THYMIDINE PHOSPHORYLASE DEOA (TDRPASE) (PYRIMIDINE PHOSPHORYLASE)" /protein_id="CAA17086.1" /db_xref="GI:2894224" /db_xref="GOA:O53366" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="UniProtKB/Swiss-Prot:O53366" /translation="MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMS ALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVP VVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQ LAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQA RELAHTMVELGAAHGVPTRALLTEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELT LRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLSKPLPIGSHSETVTAG ASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYT NAPERFGAARAELAGGWSIRDSPPQVRPLIVDRIV" misc_feature complement(235409..235462) /gene="deoA" /locus_tag="Rv3314c" /note="PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature" gene complement(235801..236202) /gene="cdd" /locus_tag="Rv3315c" CDS complement(235801..236202) /gene="cdd" /locus_tag="Rv3315c" /EC_number="3.5.4.5" /function="THIS ENZYME SCAVENGE EXOGENOUS AND ENDOGENOUS CYTIDINE AND 2'-DEOXYCYTIDINE FOR UMP SYNTHESIS [CATALYTIC ACTIVITY: CYTIDINE + H(2)O = URIDINE + NH(3)]." /note="Rv3315c, (MTV016.15c), len: 133 aa. Probable cdd, cytidine deaminase (EC 3.5.4.5), equivalent to Q9CBD3|CDD|ML2174 CYTIDINE DEAMINASE from Mycobacterium leprae (134 aa), FASTA scores: opt: 516, E(): 5.8e-28, (56.8% identity in 132 aa overlap). Also highly similar to many e.g. Q9AK37|2SCK8.15 from Streptomyces coelicolor (130 aa), FASTA scores: opt: 523, E(): 1.9e-28, (60.0% identity in 130 aa overlap); Q9KD53|CDD|BH1366 from Bacillus halodurans (132 aa), FASTA scores: opt: 305, E(): 9.2e-14, (41.55% identity in 130 aa overlap); P56389|CDD_MOUSE|CDA|CDD from Mus musculus (Mouse) (146 aa), FASTA scores: opt: 287, E(): 1.6e-12, (40.3% identity in 124 aa overlap); P19079|CDD_BACSU (136 aa), FASTA scores: opt: 270, E(): 2.1e-11, (28.6% identity in 127 aa overlap); etc. Contains PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. BELONGS TO THE CYTIDINE AND DEOXYCYTIDYLATE DEAMINASES FAMILY. COFACTOR: ZINC (BY SIMILARITY). TBparse score is 0.917." /codon_start=1 /transl_table=11 /product="PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE)" /protein_id="CAA17087.1" /db_xref="GI:2894225" /db_xref="GOA:O53367" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="UniProtKB/TrEMBL:O53367" /translation="MPDVDWNMLRGNATQAAAGAYVPYSRFAVGAAALVDDGRVVTGC NVENVSYGLTLCAECAVVCALHSTGGGRLLALACVDGHGSVLMPCGRCRQVLLEHGGS ELLIDHPVRPRRLGDLLPDAFGLDDLPRERR" misc_feature complement(235915..236037) /gene="cdd" /locus_tag="Rv3315c" /note="PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature" gene 236439..236777 /gene="sdhC" /locus_tag="Rv3316" CDS 236439..236777 /gene="sdhC" /locus_tag="Rv3316" /EC_number="1.3.99.1" /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE. MONO-HEME CYTOCHROME OF THE SUCCINATE DEHYDROGENASE COMPLEX." /note="Rv3316, (MTV016.16), len: 112 aa. Probable sdhC, cytochrome B-556 of succinate dehydrogenase SdhC subunit (EC 1.3.99.1), transmembrane protein, equivalent (but shorter 35 aa) to Q9CCM0|SDHC|ML0699 PUTATIVE SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT from Mycobacterium leprae (153 aa), FASTA scores: opt: 692, E(): 1.2e-39, (88.4% identity in 112 aa overlap). Also similar to others e.g. Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126 aa), FASTA scores: opt: 484, E(): 8.3e-26, (65.65% identity in 99 aa overlap); Q9RVR8|DR0954 from Deinococcus radiodurans (118 aa), FASTA scores: opt: 195, E(): 1.7e-06, (36.8% identity in 87 aa overlap); Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium sp. strain NRC-1 (130 aa), FASTA scores: opt: 192, E(): 2.9e-06, (37.85% identity in 74 aa overlap); P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis (Natronobacterium pharaonis) (130 aa), FASTA scores: opt: 183, E(): 1.1e-05, (35.15% identity in 74 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. BELONGS TO THE CYTOCHROME B560 FAMILY. TBparse score is 0.893" /codon_start=1 /transl_table=11 /product="PROBABLE SUCCINATE DEHYDROGENASE (CYTOCHROME B-556 SUBUNIT) SDHC (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)" /protein_id="CAA17088.1" /db_xref="GI:2894226" /db_xref="GOA:O53368" /db_xref="InterPro:IPR000701" /db_xref="UniProtKB/TrEMBL:O53368" /translation="MWSWVCHRISGATIFFFLFVHVLDAAMLRVSPQTYNAVLATYKT PIVGLMEYGLVAAVLFHALNGIRVILIDFWSEGPRYQRLMLWIIGSVFLLLMVPAGVV VGIHMWEHFR" gene 236774..237208 /gene="sdhD" /locus_tag="Rv3317" CDS 236774..237208 /gene="sdhD" /locus_tag="Rv3317" /EC_number="1.3.99.1" /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE. PUTATIVE HYDROPHOBIC COMPONENT OF THE SUCCINATE DEHYDROGENASE COMPLEX. COULD BE REQUIRED TO ANCHOR THE CATALYTIC COMPONENTS TO THE CYTOPLASMIC MEMBRANE" /note="Rv3317, (MTV016.17), len: 144 aa. Probable sdhD, membrane anchor of succinate dehydrogenase SdhD subunit (EC 1.3.99.1), equivalent (but shorter 19 aa) to Q49915|SDHD|ML0698|L308_F1_25 PUTATIVE SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN from Mycobacterium leprae (163 aa), FASTA scores: opt: 878, E(): 1.9e-51, (85.2% identity in 142 aa overlap). Also similar to others e.g. Q9KZ89|SC5G8.25c from Streptomyces coelicolor (160 aa), FASTA scores: opt: 553, E(): 6.6e-30, (58.85% identity in 141 aa overlap); Q9RVR9|DR0953 from Deinococcus radiodurans (125 aa), FASTA scores: opt: 251, E(): 5.5e-10, (37.15% identity in 113 aa overlap); O29573|DHSD_ARCFU|SDHD|AF0684 from Archaeoglobus fulgidus (117 aa), FASTA scores: opt: 160, E(): 0.00056, (25.95% identity in 108 aa overlap); etc. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. TBparse score is 0.905." /codon_start=1 /transl_table=11 /product="PROBABLE SUCCINATE DEHYDROGENASE (HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT) SDHD (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)" /protein_id="CAA17089.1" /db_xref="GI:2894227" /db_xref="GOA:O53369" /db_xref="UniProtKB/TrEMBL:O53369" /translation="MSAPVRQRSHDRPASLDNPRSPRRRAGMPNFEKFAWLFMRFSGV VLVFLAIGHVFIMLMWDNGVYRLDFNFVAQRWASPFWQTWDLLLLWLAQLHGGNGLRT IIDDYSRKDTTRFWLNSLLVLSMLFTLMLGTYVIVTFDPNIS" repeat_unit complement(237232..237341) /note="110 bp Mycobacterial Interspersed Repetitive Unit, Class III" gene 237337..239109 /gene="sdhA" /locus_tag="Rv3318" CDS 237337..239109 /gene="sdhA" /locus_tag="Rv3318" /EC_number="1.3.99.1" /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE. MEMBRANE-BOUND FAD-CONTAINING ENZYME WHICH IS RESPONSIBLE FOR SUCCINATE INTERCONVERSION [CATALYTIC ACTIVITY: SUCCINATE + ACCEPTOR = FUMARATE + REDUCED ACCEPTOR]." /note="Rv3318, (MTV016.18), len: 590 aa. Probable sdhA, flavoprotein of succinate dehydrogenase SdhA subunit (EC 1.3.99.1), equivalent to Q9CCM1|SDHA|ML0697 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT from Mycobacterium leprae (584 aa), FASTA scores: opt: 3657, E(): 1.2e-217, (92.55% identity in 590 aa overlap). Also highly similar to others e.g. Q9KZ90|DHSA from Streptomyces coelicolor (584 aa), FASTA scores: opt: 2813, E(): 1.1e-165, (70.5% identity in 586 aa overlap); Q9RVS0|DR0952 from Deinococcus radiodurans (583 aa), FASTA scores: opt: 2203, E(): 4.1e-128, (57.35% identity in 593 aa overlap); P31038|DHSA_RICPR|SDHA|RP128 from Rickettsia prowazekii (596 aa), FASTA scores: opt: 1892, E(): 5.8e-109, (50.0% identity in 588 aa overlap); P10444|DHSA_ECOLI|SDHA|B0723|Z0877|ECS0748 from Escherichia coli strains K12 and O157:H7 (588 aa), FASTA scores: opt: 1844, E(): 5.2e-106, (48.75% identity in 591 aa overlap); etc. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. COFACTOR: FAD. SIMILAR TO THE FLAVOPROTEIN SUBUNITS OF OTHER SPECIES SUCCINATE DEHYDROGENASE AND OF FUMARATE REDUCTASE. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. TBparse score is 0.873." /codon_start=1 /transl_table=11 /product="PROBABLE SUCCINATE DEHYDROGENASE (FLAVOPROTEIN SUBUNIT) SDHA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)" /protein_id="CAA17090.1" /db_xref="GI:2894228" /db_xref="GOA:O53370" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR001327" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR004112" /db_xref="InterPro:IPR010959" /db_xref="InterPro:IPR011281" /db_xref="UniProtKB/TrEMBL:O53370" /translation="MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHT GAAQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGM PFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN EFYALDLALTQTPSGPVATGVIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHT LTGDGIGIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMER YAPTIVDLAPRDIVARSMVLEVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFA RTYLGVDPVTELVPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHG ANRLGTNSLLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEHGNER VADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHDKGKRFNTDLLEA IELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKEIGADKEGPE LRSDVRLDFKPVVQTRYEPKERKY" misc_feature 237457..237486 /gene="sdhA" /locus_tag="Rv3318" /note="PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site" gene 239109..239900 /gene="sdhB" /locus_tag="Rv3319" CDS 239109..239900 /gene="sdhB" /locus_tag="Rv3319" /EC_number="1.3.99.1" /function="INVOLVED IN TRICARBOXYLIC ACID CYCLE. MEMBRANE-BOUND FAD-CONTAINING ENZYME WHICH IS RESPONSIBLE FOR SUCCINATE INTERCONVERSION [CATALYTIC ACTIVITY: SUCCINATE + ACCEPTOR = FUMARATE + REDUCED ACCEPTOR]." /note="Rv3319, (MTV016.19), len: 263 aa. Probable sdhB, iron-sulphur protein succinate dehydrogenase SdhB subunit (EC 1.3.99.1), equivalent to Q49916|SDHB|ML0696|L308_F1_28 SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN from Mycobacterium leprae (264 aa), FASTA scores: opt: 1678, E(): 4.7e-99, (89.8% identity in 264 aa overlap). Also highly similar to other e.g. Q9KZ91|DHSB from Streptomyces coelicolor (257 aa), FASTA scores: opt: 1125, E(): 4.6e-64, (64.1% identity in 262 aa overlap); Q9RVS1|DR0951 from Deinococcus radiodurans (264 aa), FASTA scores: opt: 1014, E(): 5e-57, (57.25% identity in 255 aa overlap); Q9PEF5|XF1073 from Xylella fastidiosa (261 aa), FASTA scores: opt: 681, E(): 5.8e-36, (45.1% identity in 244 aa overlap); P07014|DHSB_ECOLI|SDHB|B0724 from Escherichia coli strain K12 (238 aa), FASTA scores: opt: 657, E(): 1.8e-34, (43.75% identity in 240 aa overlap); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. COFACTOR: BINDS THREE DIFFERENT IRON-SULFUR CLUSTERS: A 2FE-2S, A 3FE-4S AND A 4FE-4S. THE IRON-SULFUR CENTERS ARE SIMILAR TO THOSE OF 'PLANT-TYPE' 2FE-2S AND 'BACTERIAL-TYPE' 4FE-4S FERREDOXINS. PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN, AN IRON-SULFUR, CYTOCHROME B-556, AND AN HYDROPHOBIC ANCHOR PROTEIN. TBparse score is 0.876." /codon_start=1 /transl_table=11 /product="PROBABLE SUCCINATE DEHYDROGENASE (IRON-SULPHUR PROTEIN SUBUNIT) SDHB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)" /protein_id="CAA17091.1" /db_xref="GI:2894229" /db_xref="GOA:O53371" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR001450" /db_xref="InterPro:IPR004489" /db_xref="UniProtKB/TrEMBL:O53371" /translation="MSVEPDVETLDPPLPPVPDGAVMVTVKIARFNPDDPDAFAATGG WQSFRVPCLPSDRLLNLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVL MRDLLPKKKGKSLTVTVEPIRGLPVEKDLVVDMEPFFDAYRAIKPYLITSGNPPTRER IQSPTDRARYDDTTKCILCACCTTSCPVFWHEGSYFGPAAIVNAHRFIFDSRDEAAAE RLDILNEVDGVWRCRTTFNCTESCPRGIEVTKAIQEVKRALMFTR" misc_feature 239634..239669 /gene="sdhB" /locus_tag="Rv3319" /note="PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature" gene complement(239979..240407) /locus_tag="Rv3320c" CDS complement(239979..240407) /locus_tag="Rv3320c" /function="UNKNOWN" /note="Rv3320c, (MTV016.20c), len: 142 aa. Conserved hypothetical protein, similar to several hypothetical proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. P95023|Rv2530c|MTCY159.26 (139 aa), FASTA scores: opt: 292, E(): 4.8e-14, (41.5% identity in 135 aa overlap); O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt: 287, E(): 1.1e-13, (41.6% identity in 125 aa overlap); O07760|Rv0617|MTCY19H5.04c (133 aa), FASTA scores: opt: 252, E(): 3.3e-11, (37.8% identity in 127 aa overlap); etc. TBparse score is 0.934." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17092.1" /db_xref="GI:2894230" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR006226" /db_xref="UniProtKB/TrEMBL:O53372" /translation="MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQN GFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFWSCTVSILDSKVIDRSRLHSPKQ VTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL" gene complement(240411..240653) /locus_tag="Rv3321c" CDS complement(240411..240653) /locus_tag="Rv3321c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3321c, (MTV016.21c), len: 80 aa. Conserved hypothetical protein, similar at N-terminal region to several proteins from Mycobacterium tuberculosis (strains H37Rv and CDC1551) e.g. AAK48167|MT3800 DNA-BINDING PROTEIN (COPG FAMILY) from strain CDC1551 (74 aa), FASTA scores: opt: 142, E(): 0.0016, (48.85% identity in 43 aa overlap); AAK46916|MT2606 HYPOTHETICAL 8.0 KDA PROTEIN from strain CDC1551 (74 aa), FASTA scores: opt: 139, E(): 0.0026, (37.2% identity in 78 aa overlap); O50456|Rv1241|MTV006.13 HYPOTHETICAL 9.9 KDA PROTEIN from strain H37Rv (86 aa), FASTA scores: opt: 134, E(): 0.0066, (39.0% identity in 82 aa overlap); etc. TBparse score is 0.906." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17093.1" /db_xref="GI:2894231" /db_xref="GOA:O53373" /db_xref="UniProtKB/TrEMBL:O53373" /translation="MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQ PAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV" gene complement(240775..241389) /locus_tag="Rv3322c" CDS complement(240775..241389) /locus_tag="Rv3322c" /EC_number="2.1.1.-" /function="COULD CAUSE METHYLATION." /note="Rv3322c, (MTV016.22c), len: 204 aa. Conserved hypothetical protein, showing weak similarity to proteins including several methyltransferases (EC 2.1.1.-) e.g. Q9X9V1|ORF8 PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (208 aa), FASTA scores: opt: 193, E(): 1e-05, (36.35% identity in 132 aa overlap); and Q9XA90|SCF43A.25c PUTATIVE METHYLTRANSFERASE from Streptomyces coelicolor (215 aa), FASTA scores: opt: 161, E(): 0.0014, (32.05% identity in 131 aa overlap); P74712|SLR1183 HYPOTHETICAL 21.3 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (194 aa), FASTA scores: opt: 155, E(): 0.0032, (27.35% identity in 150 aa overlap); Q9ABW8|CC0102 RRNA METHYLTRANSFERASE RSMB from Caulobacter crescentus (429 aa), FASTA scores: opt: 148, E(): 0.018, (31.5% identity in 162 aa overlap); etc. Also highly similar to O05796|Rv3120|MTCY164.30 HYPOTHETICAL 21.8 KDA PROTEIN from Mycobacterium tuberculosis (200 aa), FASTA scores: opt: 691, E(): 1.2e-38, (56.5% identity in 200 aa overlap); and shows weak similarity to O69667|Rv3699|MTV025.047 PUTATIVE METHYLTRANSFERASE from Mycobacterium tuberculosis (233 aa), FASTA scores: opt: 155, E(): 0.0037, (29.15% identity in 168 aa overlap). TBparse score is 0.927." /codon_start=1 /transl_table=11 /product="POSSIBLE METHYLTRANSFERASE" /protein_id="CAE55582.1" /db_xref="GI:38490354" /db_xref="GOA:O53374" /db_xref="InterPro:IPR000051" /db_xref="UniProtKB/TrEMBL:O53374" /translation="MSVQTDPALREHPNRVDWNARYERAGSAHAPFAPVPWLADVLRA GVPDGPVLELASGRSGTALALAAHGRQVTAIDVSDVALLQLDSEAVRRGVADRLNLVQ ADLGCWEPGETRFALVLSRLFWDAAIFHRACEAVMPGGVLAWESLALSGAEAGTASAK RRVKPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSPLPGA" gene complement(241386..242051) /gene="moaX" /locus_tag="Rv3323c" CDS complement(241386..242051) /gene="moaX" /locus_tag="Rv3323c" /function="THOUGHT TO BE INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS." /note="Rv3323c, (MTV016.23c), len: 221 aa. Probable moaX, MoaD-MoaE fusion protein, similar (whole or partial) to several MoaD and MoaE proteins e.g. Q9RR88|DR2607 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D/E from Deinococcus radiodurans (229 aa), FASTA scores: opt: 407, E(): 1.8e-18, (32.75% identity in 223 aa overlap); Q9K8I7|MOAE|BH3019 MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus halodurans (156 aa), FASTA scores: opt: 375, E(): 1.3e-16, (41.65% identity in 132 aa overlap); O31705|MOAE MOLYBDOPTERIN CONVERTING FACTOR (SUBUNIT 2) from Bacillus subtilis (157 aa), FASTA scores: opt: 368, E(): 3.6e-16, (41.65% identity in 132 aa overlap); etc. C-terminus highly similar to O05795|MOAE_MYCTU|Rv3119|MT3201|MTCY164.29|MOAE1 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E from Mycobacterium tuberculosis (147 aa), FASTA scores: opt: 733, E(): 5.4e-39, (76.2% identity in 143 aa overlap); and N-terminus highly similar to O05789|MOAD1|Rv3112|MTCY164.22 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D from Mycobacterium tuberculosis (83 aa), FASTA scores: opt: 333, E(): 3.2e-14, (65.05% identity in 83 aa overlap). TBparse score is 0.941." /codon_start=1 /transl_table=11 /product="PROBABLE MOAD-MOAE FUSION PROTEIN MOAX" /protein_id="CAE55583.1" /db_xref="GI:38490355" /db_xref="GOA:Q6MWY3" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="UniProtKB/TrEMBL:Q6MWY3" /translation="MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPP LADFRKRVRMAVNESIAPASTILDDGDTVAFIPQVAGGSDVYCRLTDEPLSVDEVLNA ISGPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVA VAHRTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVA NRP" gene complement(242052..242585) /gene="moaC3" /locus_tag="Rv3324c" CDS complement(242052..242585) /gene="moaC3" /locus_tag="Rv3324c" /function="THOUGHT TO BE INVOLVED IN THE BIOSYNTHESIS OF MOLYBDOPTERIN." /note="Rv3324c, (MTV016.24c), len: 177 aa. Probable moaC3, molybdopterin cofactor biosynthesis protein, highly similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas aeruginosa (160 aa), FASTA scores: opt: 567, E(): 7.5e-30, (58.35% identity in 156 aa overlap); Q9RKA8|MOAC from Streptomyces coelicolor (170 aa), FASTA scores: opt: 553, E(): 6.3e-29, (58.25% identity in 158 aa overlap); P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain K12 (160 aa), FASTA scores: opt: 516, E(): 1.5e-26, (55.95% identity in 159 aa overlap); etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 734, E(): 1.3e-40, (71.8% identity in 163 aa overlap); and Rv0864|MOAC2|MTV043.57 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN (167 aa). TBparse score is 0.926." /codon_start=1 /transl_table=11 /product="PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 3 MOAC3" /protein_id="CAA17096.1" /db_xref="GI:2894234" /db_xref="GOA:P65392" /db_xref="InterPro:IPR002820" /db_xref="UniProtKB/Swiss-Prot:P65392" /translation="MNDHDGVLTHLDEQGAARMVDVSAKAVTLRRARASGAVLMKPST LDMICHGTAAKGDVIATARIAGIMAAKRTGELIPLCHPLGIEAVTVTLEPQGADRLSI AATVTTVARTGVEMEALTAVTVTALTVYDMCKAVDRAMTITDIRLDEKSGGRSGHYRR HDADVKPSDGGSTEDGC" gene complement(242585..242716) /locus_tag="Rv3324A" /pseudo CDS complement(242585..242716) /locus_tag="Rv3324A" /function="THOUGHT TO BE INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS. CATALYZES THE DEHYDRATATION OF 4A-HYDROXYTETRAHYDROPTERINS [CATALYTIC ACTIVITY: (6R)-6-(L-ERYTHRO-1,2-DIHYDROXYPROPYL)-5,6,7,8-TETRAHYDRO -4 A-HYDROXYPTERIN = (6R)-6-(L-ERYTHRO-1,2- DIHYDROXYPROPYL)-7,8-DIHYDRO-6H-PTERIN + H(2)O]." /note="Rv3324A, 44 aa. Probable pseudogene moaB3, fragment of pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96), equivalent to C-terminus of MT3426|Q8VJ32 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium tuberculosis strain CDC1551 (124 aa), FASTA scores: opt: 309, E(): 1.1e-20, (100.000% identity in 44 aa overlap), and C-terminus of Mb3354c|moaB3 PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE from Mycobacterium bovis (124 aa). Note that a deletion of DNA (RvD5 region) in Mycobacterium tuberculosis strain H37Rv resulted in a truncated CDS comparatively to Mycobacterium bovis or Mycobacterium tuberculosis strain CDC1551 genomes (see citations below)." /pseudo /codon_start=1 /transl_table=11 /product="PROBABLE FRAGMENT OF PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB3 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE) (PCD)" repeat_region 242719..244073 /note="IS6110-14, len: 1355 bp. Insertion sequence IS6110." /insertion_seq="IS6110-14" repeat_unit 242719..242746 /note="28 bp inverted repeat at left end of IS6110, TGAACCGCCCCGGCATGTCCGGAGACTC" gene 242770..243096 /locus_tag="Rv3325" CDS 242770..243096 /locus_tag="Rv3325" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE ELEMENT IS6110." /note="Rv3325, (MTV016.25), len: 108 aa. Probable transposase for insertion element IS6110. BELONGS TO THE TRANSPOSASE FAMILY 8. TBparse score is 0.928." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA17097.1" /db_xref="GI:2894235" /db_xref="GOA:Q50686" /db_xref="InterPro:IPR002514" /db_xref="InterPro:IPR009057" /db_xref="UniProtKB/Swiss-Prot:Q50686" /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE LDRPAR" gene <243093..244031 /locus_tag="Rv3326" CDS <243093..244031 /locus_tag="Rv3326" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE ELEMENT IS6110." /note="Rv3326, (MTV016.26), len: 312 aa. Probable transposase for insertion element IS6110. TBparse score is 0.926." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA17098.1" /db_xref="GI:2894236" /db_xref="GOA:P19774" /db_xref="UniProtKB/Swiss-Prot:P19774" /translation="LITRFIADHQGHREGPDGLRWGVESICTQLTELGVPIAPSTYYD HINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTK LGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVA FVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTS IRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATAR WVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG" repeat_unit complement(244046..244073) /note="28 bp inverted repeat at right end of IS6110, TGAACCGCCCCGGTGAGTCCGGAGACTC" repeat_region 244074..245159 /note="IS1547-2, len: 1086 bp. Region corresponding to Insertion sequence IS1547, positions 1982 3067 in EM_NEW:MTY13470." /insertion_seq="IS1547-2" gene 244086..245798 /locus_tag="Rv3327" CDS 244086..245798 /locus_tag="Rv3327" /function="INVOLVED IN THE TRANSPOSITION IN THE INSERTION SEQUENCE ELEMENT IS1547." /note="Rv3327, (MTV016.27), len: 570 aa. Probable fusion protein. Indeed, N-terminal part corresponds to entire O07269 transposase of IS1547 (383 aa), and C-terminal part identical to MTCI249B.03c (210 aa). N-terminal part is identical to MTV042_7 (188 aa); C-terminal part (aa 378-570) is similar to hypothetical 20.5 kDa protein from Escherichia coli P76222|YNJA_ECOLI (182 aa), FASTA scores: opt: 292, E(): 5.3e-11, (32.6% identity in 181 aa overlap). TBparse score is 0.910." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE FUSION PROTEIN" /protein_id="CAA17099.1" /db_xref="GI:2894237" /db_xref="GOA:O53377" /db_xref="InterPro:IPR002525" /db_xref="InterPro:IPR003346" /db_xref="UniProtKB/TrEMBL:O53377" /translation="MVVVGTDAHKYSHTFVATDEVGRQLGEKTVKATTAGHATAIMWA REQFGLELIWGIEDCRNMSARLERDLLAAGQQVVRVPTKLMAQTRKSARSRGKSDPID ALAVARAVLRETDLPLATHDETSRELKLLTDRRDVLVAQRTSAINRLRWLVHELDPER APAARSLDAAKHQQALRTWLDTQPGLVAELARAELTDIIRLTGEINTLAQRISARVHQ VAPALLEIPGCAELTAAKIVGEAAGVTRFKSEAAFACHAAVAPIPVWSGNTAGQMRLS RSGNRQLNAALHRIALTQIRMTDSRGQAYYQRLQDAGKTKRAALRCLKRRLARTVFQA LRTVHQPSSEHTQPAAACHRSYCSSHLGEPPRLTDMTQKTRIQPLPPKRAGLLIRALY RIAKRRFGEVPEPFTVTAHHRRLLIANVVHEALLQRASRKLPPSVRELAVFWTARSIG CSWCVDFGAMLQRLDGLDVDRLTDIDNYATSSKFSDDERAAIAYAEAMTADPHSVTDE QVADLRARFGEAGVIELTYQIGVENMRARMNSALGITEQGFNSGDACRVPWAAPDVPS AESR" gene complement(245731..246669) /gene="sigJ" /locus_tag="Rv3328c" CDS complement(245731..246669) /gene="sigJ" /locus_tag="Rv3328c" /function="THE SIGMA FACTOR IS AN INITIATION FACTOR THAT PROMOTES ATTACHMENT OF THE RNA POLYMERASE TO SPECIFIC INITIATION SITES AND THEN IS RELEASED." /note="Rv3328c, (MTV016.28c), len: 312 aa. Probable sigJ, alternative RNA polymerase sigma factor (see citations below), highly similar to many e.g. Q9K3H7|2SCG18.10c from Streptomyces coelicolor (295 aa), FASTA scores: opt: 642, E(): 7.3e-31, (42.8% identity in 292 aa overlap); Q9A3D8|CC3266 from Caulobacter crescentus (291 aa), FASTA scores: opt: 607, E(): 8.4e-29, (39.8% identity in 294 aa overlap); Q9RD74|SCF43.14c from Streptomyces coelicolor (324 aa), FASTA scores: opt: 555, E(): 1.1e-25, (41.1% identity in 297 aa overlap); etc. Similar also to U00022_20 from Mycobacterium leprae; and MTCI28_22 and MSU87307_1. Also similar to O50445|SIGI|Rv1189|MTV005.25|MTCI364.01 PUTATIVE RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (290 aa), FASTA scores: opt: 426, E(): 4.2e-18, (32.65% identity in 294 aa overlap). Equivalent to AAK47774 from Mycobacterium tuberculosis strain CDC1551 (282 aa) but longer 30 aa. Contains probable helix-turn-helix motif at aa 129-150 (Score 1126, +3.02 SD). BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. TBparse score is 0.883." /codon_start=1 /transl_table=11 /product="PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR (FRAGMENT) SIGJ" /protein_id="CAA17100.1" /db_xref="GI:2894238" /db_xref="GOA:O53378" /db_xref="InterPro:IPR007627" /db_xref="UniProtKB/TrEMBL:O53378" /translation="MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRWDSPDTV IADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWLPEPVVTGLDATDPLAAVVAAEDA RFAAMVVLERLRPDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQP ALISGDPDPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGS DKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRD GKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN" gene 246729..248045 /locus_tag="Rv3329" CDS 246729..248045 /locus_tag="Rv3329" /EC_number="2.6.1.-" /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR METABOLISM." /note="Rv3329, (MTV016.29), len: 438 aa (start uncertain). Probable aminotransferase (EC 2.6.1.-), similar to many e.g. O86744|SC6A9.12 from Streptomyces coelicolor (457 aa), FASTA scores: opt: 2120, E(): 5.1e-125, (70.1% identity in 438 aa overlap); Q9I6J2|PA0299 from Pseudomonas aeruginosa (456 aa), FASTA scores: opt: 983, E(): 5.7e-54, (38.1% identity in 425 aa overlap); Q53196|Y4UB_RHISN from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (467 aa), FASTA scores: opt: 971, E(): 3.3e-53, (39.25% identity in 438 aa overlap); P33189|YHXA_BACSU from Bacillus subtilis (450 aa), FASTA scores: opt: 933, E(): 7.5e-51, (40.25% identity in 435 aa overlap); etc. Equivalent to AAK47775 from Mycobacterium tuberculosis strain CDC1551 (466 aa) but shorter 28 aa. COFACTOR: PYRIDOXAL PHOSPHATE. COULD BELONG TO CLASS-III OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES. TBparse score is 0.881." /codon_start=1 /transl_table=11 /product="PROBABLE AMINOTRANSFERASE" /protein_id="CAA17101.1" /db_xref="GI:2894239" /db_xref="GOA:O53379" /db_xref="InterPro:IPR005814" /db_xref="UniProtKB/TrEMBL:O53379" /translation="MHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVG YGRAELAEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPGDLNRVFFTSGGTEAV ETAWKVAKQYFKLTGKPGKQKVISRSIAYHGTTQGALAITGLPLFKAPFEPLTPGGFR VPNTNFYRAPLHTDLKEFGRWAADRIAEAIEFEGPDTVAAVFLEPVQNAGGCIPAPPG YFERVREICDRYDVLLVSDEVICAFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLG AMIASDRLFEPFNDGETMFAHGYTFGGHPVSAAVGLANLDIFEREGLSDHVKRNSPAL RATLEKLYDLPIVGDIRGEGYFFGIELVKDQATKQTFTDDERARLLGQVSAALFEAGL YCRTDDRGDPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL" gene 248114..249331 /gene="dacB1" /locus_tag="Rv3330" CDS 248114..249331 /gene="dacB1" /locus_tag="Rv3330" /EC_number="3.4.16.4" /function="INVOLVED IN PEPTIDOGLYCAN SYNTHESIS (AT FINAL STAGES). HYDROLYZES THE BOUND D-ALANYL-D-ALANINE [CATALYTIC ACTIVITY: D-ALANYL-D-ALANINE + H(2)O = 2 D-ALANINE]." /note="Rv3330, (MTV016.30), len: 405 aa. Probable dacB1, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) (EC 3.4.16.4), equivalent to Mycobacterium leprae proteins Q9CCM2|ML0691 PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (411 aa), FASTA scores: opt: 2066, E(): 2.5e-102, (77.15% identity in 416 aa overlap); Q49917|L308_F1_36 (228 aa), FASTA scores: opt: 1241, E(): 7.9e-59, (78.9% identity in 232 aa overlap) (note that this protein corresponds to C-terminal part of the putative protein encoded by Rv3330, aa 174-405); and Q49921|PBPC (182 aa), FASTA scores: opt: 736, E(): 3.7e-32, (73.95% identity in 169 aa overlap) (note that this protein corresponds to N-terminal part of the putative protein encoded by Rv3330, aa 1-158); note L308_F1_36 (228 aa) and PBPC (182 aa) are two consecutive Mycobacterium leprae ORFs . Also similar to others e.g. Q9FC34|SC4G1.16c PUTATIVE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Streptomyces coelicolor (413 aa), FASTA scores: opt: 572, E(): 3.4e-23, (33.75% identity in 382 aa overlap); P35150|DACB_BACSU PENICILLIN-BINDING PROTEIN 5* PRECURSOR (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) from Bacillus subtilis (382 aa), FASTA scores: opt: 422, E(): 2.8e-15, (31.3% identity in 249 aa overlap); Q9K8X5|DACB|BH2877 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE (PENICILLIN-BINDING PROTEIN) from Bacillus halodurans (395 aa), FASTA scores: opt: 421, E(): 3.2e-15, (31.95% identity in 241 aa overlap); etc. Also similar to Mycobacterium tuberculosis Q10828|Rv2911|MTCY274.43 PROBABLE PENICILLIN-BINDING PROTEIN (BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY) (291 aa), FASTA scores: opt: 746, E(): 1.6e-32, (47.0% identity in 266 aa overlap). Has hydrophobic stretches at both N- and C-termini. Certainly membrane-bound protein. BELONGS TO PEPTIDASE FAMILY S11; ALSO KNOWN AS THE D-ALANYL-D-ALANINE CARBOXYPEPTIDASE 1 FAMILY. TBparse score is 0.871." /codon_start=1 /transl_table=11 /product="PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE)" /protein_id="CAA17102.1" /db_xref="GI:2894240" /db_xref="GOA:O53380" /db_xref="InterPro:IPR001967" /db_xref="UniProtKB/TrEMBL:O53380" /translation="MAFLRSVSCLAAAVFAVGTGIGLPTAAGEPNAAPAACPYKVSTP PAVDSSEVPAAGEPPLPLVVPPTPVGGNALGGCGIITAPGSAPAPGDVSAEAWLVADL DSGAVIAARDPHGRHRPASVIKVLVAMASINTLTLNKSVAGTADDAAVEGTKVGVNTG GTYTVNQLLHGLLMHSGNDAAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGL DGPGMSTSAYDIGLFYRYAWQNPVFADIVATRTFDFPGHGDHPGYELENDNQLLYNYP GALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQAAHLLDYGFNTPA GTQIGTLIEPDPSLMSTDRNPADRQRVDPQAAARISAADALPVRVGVAVIGALIVFGL IMVARAMNRRPQH" gene 249427..250935 /gene="sugI" /locus_tag="Rv3331" CDS 249427..250935 /gene="sugI" /locus_tag="Rv3331" /function="THOUGHT TO BE INVOLVED IN TRANSPORT OF SUGAR ACROSS THE MEMBRANE. RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE." /note="Rv3331, (MTV016.31), len: 502 aa (start uncertain). Probable sugI, sugar-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to several transporters e.g. P37021|GALP_ECOLI|B2943 GALACTOSE-PROTON SYMPORTER (GALACTOSE TRANSPORTER) from Escherichia coli strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39, (31.85% identity in 446 aa overlap); P96742|YWTG METABOLITE-TRANSPORT-RELATED PROTEIN from Bacillus subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39, (33.2% identity in 428 aa overlap); AAG58074|GALP (alias BAB37242|ECS3819) GALACTOSE-PROTON SYMPORT OF TRANSPORT SYSTEM from Escherichia coli strain O157:H7 EDL933 (464 aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity in 432 aa overlap); P46333|CSBC_BACSU|SS92BR PROBABLE METABOLITE TRANSPORT PROTEIN from Bacillus subtilis (461 aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from Mycobacterium tuberculosis strain CDC1551 (500 aa) but with some divergence between residues 229 and 254. Contains PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2. BELONGS TO THE SUGAR TRANSPORTER FAMILY. TBparse score is 0.869." /codon_start=1 /transl_table=11 /product="PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN SUGI" /protein_id="CAA17103.1" /db_xref="GI:2894241" /db_xref="GOA:O53381" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR007114" /db_xref="UniProtKB/TrEMBL:O53381" /translation="MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQL TRSGRRALLVGLTAASVGVLYGYDLSAIAGALLSLSEEFELTTREQELLTTTAVLGQI AGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVPMLVVARLLLGVTIGLSVV VVPVYVAESAPAAVRGSLVTAYQLATLSGIVVGYLVGYLLAGSHGWRAMFGLAAAPAT LLLPLLWRMPDTARWYLLKGRIADARSALRRIQPEADIDAELADMAAAVDERGGGIGE MVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGFAGYFAMLALPAMVQVAG LAAVCASLFLVDRLGRRPILLSGIATMITADAVLITVFANDSDGGTGLVLGFAGVLLF IIGFNFGFGSLVWVYAAESFPSRLRSMGSSPMLTSTLTANAIVAAFSLTMLRVLGGAG VFAVFGTFAVVAFVVVYRFAPETKGRKLEEIRHFWENGGRWPAERSPAADEP" misc_feature 249874..249951 /gene="sugI" /locus_tag="Rv3331" /note="PS00217 Sugar transport proteins signature 2" misc_feature 250447..250497 /gene="sugI" /locus_tag="Rv3331" /note="PS00216 Sugar transport proteins signature 1" gene 250932..252083 /gene="nagA" /locus_tag="Rv3332" CDS 250932..252083 /gene="nagA" /locus_tag="Rv3332" /EC_number="3.5.1.25" /function="INVOLVED IN N-ACETYL GLUCOSAMINE UTILIZATION PATHWAY [CATALYTIC ACTIVITY: N-ACETYL-D-GLUCOSAMINE 6-PHOSPHATE + H(2)O = D-GLUCOSAMINE 6-PHOSPHATE + ACETATE]." /note="Rv3332, (MTV016.32), len: 383 aa. Probable nagA, N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25), similar to many e.g. Q9KXV7|SCD95A.17c PUTATIVE DEACETYLASE from Streptomyces coelicolor (381 aa), FASTA scores: opt: 1090, E(): 1.6e-55, (47.8% identity in 385 aa overlap); Q9PDB4|XF1465 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Xylella fastidiosa (386 aa), FASTA scores: opt: 667, E(): 3.5e-31, (38.3% identity in 394 aa overlap); Q9AAZ9|CC0443 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Caulobacter crescentus (378 aa), FASTA scores: opt: 661, E(): 7.5e-31, (38.9% identity in 383 aa overlap); O34450||NAGA_BACSU N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE from Bacillus subtilis (396 aa), FASTA scores: opt: 571, E(): 1.2e-25, (32.45% identity in 376 aa overlap); etc. Equivalent to AAK47778 from Mycobacterium tuberculosis strain CDC1551 (346 aa) but longer 37 aa. BELONGS TO THE NAGA FAMILY. TBparse score is 0.881." /codon_start=1 /transl_table=11 /product="PROBABLE N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE NAGA (GLCNAC 6-P DEACETYLASE)" /protein_id="CAA17104.1" /db_xref="GI:2894242" /db_xref="GOA:O53382" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011550" /db_xref="UniProtKB/TrEMBL:O53382" /translation="MTVLGADAVVIDGRICRPGWVHTADGRILSGGAGAPPMPADAEF PDAIVVPGFVDMHVHGGGGASFADGNAADIARAAEFHLRHGTTTTLASLVTAGPAELL SAVGALAEATRDGVVAGIHLEGPWLSPARCGAHDHTRMRAPDPAEIESVLAAADGAVR MVTLAPELPGSDAAIRRFRDAEVVVAVGHTDATYTQTRHAIDLGATVGTHLFNAMPPL DHRAPGPVLALLCDPRVTVEIIADGVHVHPAVVHAVIEAVGPDRVAVVTDAIAAAGCG DGAFRLGTMPIEVESSVARVAGASTLAGSTTTMDQLFRTVAGLGSKSDSAGDVALAAA VQVTSATPARALGLTGVGRLAAGYAANLVVLDRDLRVTAVMVNDDWRVG" gene complement(252274..253119) /locus_tag="Rv3333c" CDS complement(252274..253119) /locus_tag="Rv3333c" /function="UNKNOWN" /note="Rv3333c, (MTV016.33c), len: 281 aa. Hypothetical unknown pro-rich protein. Equivalent to AAK47780 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis strain CDC1551 (265 aa) but longer 16 aa. TBparse score is 0.927." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROLINE RICH PROTEIN" /protein_id="CAA17105.1" /db_xref="GI:2894243" /db_xref="InterPro:IPR007969" /db_xref="UniProtKB/TrEMBL:O53383" /translation="MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALL EKKEIPAVANVPRVIDAAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTT TMTRFISAAVEIYCPNHHSKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVS DMTIMSPGWREPTGAMLASVLGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPP PRPAPPQQPPPPPPEVEPPAGVPQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGF IRLAP" gene 253594..254034 /locus_tag="Rv3334" CDS 253594..254034 /locus_tag="Rv3334" /function="INVOLVED IN A TRANSCRIPTIONAL MECHANISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3334, (MTV016.34), len: 146 aa. Probable transcriptional regulator, similar to many regulatory proteins (notably mercury resistance operon regulators) e.g. Q9HXV1|PA3689 PROBABLE TRANSCRIPTIONAL REGULATOR MERR FAMILY from Pseudomonas aeruginosa (156 aa), FASTA scores: opt: 275, E(): 1.6e-11, (35.95% identity in 139 aa overlap); Q9AKR6|PBRR LEAD RESISTANCE OPERON REGULATOR from Ralstonia metallidurans strain CH34 (plasmid pMOL30) (145 aa), FASTA scores: opt: 267, E(): 5.2e-11, (35.8% identity in 134 aa overlap); P95838|MERR MERCURIC RESISTANCE OPERON REGULATOR from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (144 aa), FASTA scores: opt: 266, E(): 6e-11, (31.35% identity in 118 aa overlap); P22853|MERR_BACSR MERCURIC RESISTANCE OPERON REGULATOR from Bacillus sp. strain RC607 (132 aa), FASTA scores: opt: 262, E(): 1e-10, (34.6% identity in 130 aa overlap); etc. Contains probable helix-turn-helix motif at aa 1-22 (Score 1478, +4.22 SD). SEEMS TO BELONG TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS. TBparse score is 0.911." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MERR-FAMILY)" /protein_id="CAA17106.1" /db_xref="GI:2894244" /db_xref="GOA:O53384" /db_xref="InterPro:IPR000551" /db_xref="UniProtKB/TrEMBL:O53384" /translation="MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIV DRLRFIHRGQAAGLALQEVRQILAIHDRGEAPCAHVRQLLSTRIDEVRAQIAELIALE GHLQTLLDHASYGPPTEHDHSTVCWILESDLDEPTAIEVSDIHA" gene complement(254068..254937) /locus_tag="Rv3335c" CDS complement(254068..254937) /locus_tag="Rv3335c" /function="UNKNOWN" /note="Rv3335c, (MTV016.35c), len: 289 aa. Probable conserved integral membrane protein, equivalent to Q49909|ML0687 PUTATIVE MEMBRANE PROTEIN U0308AA from Mycobacterium leprae (313 aa), FASTA scores: opt: 1299, E(): 8.9e-75, (68.75% identity in 288 aa overlap). Also similar to other hypothetical bacterial proteins e.g. BAB37825|ECS4402 from Escherichia coli strain O157:H7 (alias P37642|YHJD_ECOLI|B3522 strain K12) (337 aa), FASTA scores: opt: 591, E(): 4.2e-30, (35.15% identity in 273 aa overlap); P45417|YHJD_ERWCH from Erwinia chrysanthemi (328 aa), FASTA scores: opt: 500, E(): 2.2e-24, (34.9% identity in 275 aa overlap); Q9KZA0|SC5G8.14 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (321 aa), FASTA scores: opt: 321, E(): 4.3e-13, (27.3% identity in 271 aa overlap); etc. TBparse score is 0.902." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN" /protein_id="CAA17107.1" /db_xref="GI:2894245" /db_xref="GOA:O53385" /db_xref="InterPro:IPR004664" /db_xref="InterPro:IPR005274" /db_xref="UniProtKB/TrEMBL:O53385" /translation="MGELAEPGVLDRLRARFGWLDHVVRAFTRFNDRNGSLFAAGLTY YTIFAIFPLLMVGFGVGGFALSRRPELLTTLEERIRTSVSGAVGQQLVDLMNSAIDAR ASVGVIGLATAAWVGLGWMWHLREALSQMWAHPVAPAGYLRTKLSDLAAMVGTFVVIV ATIALTVLGHARPMAAVLRWLEIPQFSVFDEIFRGISVLVSVLVSWVLFTWMIGRLPR EPVGLVTAARAGLMAAVGFELFKQVGAIYLQIVLRSPAGAVFGPVLGLMVFAFVTAWL ILFATAWAATASA" gene complement(254958..255968) /gene="trpS" /locus_tag="Rv3336c" CDS complement(254958..255968) /gene="trpS" /locus_tag="Rv3336c" /EC_number="6.1.1.2" /function="INVOLVED IN TRANSLATION MECHANISM [CATALYTIC ACTIVITY: ATP + L-TRYPTOPHAN + TRNA(TRP) = AMP + PYROPHOSPHATE + L-TRYPTOPHANYL-TRNA(TRP)]." /note="Rv3336c, (MTV016.36c), len: 336 aa. Probable trpS, tryptophanyl-tRNA synthetase (EC 6.1.1.2), equivalent to Q49901|SYW_MYCLE|TRPS|ML0686|L308_C1_147 TRYPTOPHANYL-TRNA SYNTHETASE from Mycobacterium leprae (343 aa), FASTA scores: opt: 1859, E(): 4.8e-107, (83.75% identity in 339 aa overlap). Also similar to many e.g. Q9KZA7|TRPS2 from Streptomyces coelicolor (339 aa), FASTA scores: opt: 1359, E(): 2.6e-76, (60.3% identity in 335 aa overlap); Q9EYY6|TRPS from Klebsiella aerogenes (334 aa), FASTA scores: opt: 1077, E(): 5.5e-59, (52.15% identity in 328 aa overlap); P00954|SYW_ECOLI|TRPS|B3384 from Escherichia coli strain K12 (334 aa), FASTA scores: opt: 1074, E(): 8.3e-59, (51.85% identity in 328 aa overlap); etc. Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA SYNTHETASE FAMILY. TBparse score is 0.901." /codon_start=1 /transl_table=11 /product="PROBABLE TRYPTOPHANYL-TRNA SYNTHETASE TRPS (TRYPTOPHAN--TRNA LIGASE) (TRPRS) (TRYPTOPHAN TRANSLASE)" /protein_id="CAA17108.1" /db_xref="GI:2894246" /db_xref="GOA:P67590" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="UniProtKB/Swiss-Prot:P67590" /translation="MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFF CVVDLHAITIPQDPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGC FTGFGQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHL ELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDD PALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGD LKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRAHDVASKTVQRVYDRLGF LL" misc_feature complement(255891..255923) /gene="trpS" /locus_tag="Rv3336c" /note="PS00178 Aminoacyl-transfer RNA synthetases class-I signature" gene 255993..256379 /locus_tag="Rv3337" CDS 255993..256379 /locus_tag="Rv3337" /function="UNKNOWN" /note="Rv3337, (MTV016.37), len: 128 aa. Conserved hypothetical protein, equivalent to N-terminus of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: opt: 362, E(): 5.7e-17, (74.3% identity in 70 aa overlap). Also weak similarity in N-terminus to Q98JT7|BAB49078|MLR1789 PROBABLE EPOXIDE HYDROLASE from Rhizobium loti (Mesorhizobium loti) (300 aa), FASTA scores: opt: 122, E(): 0.74, (31.95% identity in 97 aa overlap). Homology suggests this ORF should be in frame with the following ORF MTV016.38 but no sequence error could be found. Short distance to start of trpS suggests region may not be protein-coding. TBparse score is 0.941. C-terminus extended since first submission (+47 aa)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17109.2" /db_xref="GI:38490356" /db_xref="UniProtKB/TrEMBL:O53387" /translation="MPSPSTTGHHAACGTGGTGFSVGSMRSPIRVGSGEPVLLLHPFL MSQTVWEKVAQQLADTGRFEVFAPTMAGHNGGPASGTRFCPRRCWPTTSNASSTNWAG KPAISSATRWAAGSRSNSNDVAGHAA" gene 256241..256885 /locus_tag="Rv3338" CDS 256241..256885 /locus_tag="Rv3338" /function="UNKNOWN" /note="Rv3338, (MTV016.38), len: 214 aa. Hypothetical protein, equivalent to C-termini of Q49926|ML0685 TPEA (PUTATIVE HYDROLASE) from Mycobacterium leprae (303 aa), FASTA scores: opt: 984, E(): 2.6e-56, (65.4% identity in 214 aa overlap); and O32873|MLCB1779.02 HYPOTHETICAL 31.8 KDA PROTEIN (SIMILAR TO ALPHA/BETA HYDROLASE FOLD) from Mycobacterium leprae (292 aa), FASTA scores: opt: 984, E(): 2.5e-56, (65.4% identity in 214 aa overlap). Also similar to C-termini of several hypothetical proteins (generally hydrolases) e.g. Q9K3H6|2SCG18.11 PUTATIVE HYDROLASE from Streptomyces coelicolor (316 aa), FASTA scores: opt: 213, E(): 1.4e-06, (29.75% identity in 185 aa overlap). Homology suggests that this ORF should be in frame with the previous ORF MTV016.37 but no sequence error could be found. TBparse score is 0.887." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA17110.1" /db_xref="GI:2894248" /db_xref="UniProtKB/TrEMBL:O53388" /translation="MSSAVLADHVERQLDELGWETSHIVGNSLGGWVAFELERRGRAR SVTGIAPAGGWTRWSPVKFEVIAKFIAGAPILAVAHILGQRALRLPFSRLLATLPISA TPDGVSERELSGIIDDAAHCPAYFQLLVKALVLPGLQELEHTAVPSHVVLCEQDRVVP PSRFSRHFTDSLPAGHRLTVLDGVGHVPMFEAPGRITELITSFIEECCPHVRAS" gene complement(256952..258181) /gene="icd1" /locus_tag="Rv3339c" CDS complement(256952..258181) /gene="icd1" /locus_tag="Rv3339c" /EC_number="1.1.1.42" /function="INVOLVED IN THE KREBS CYCLE [CATALYTIC ACTIVITY: ISOCITRATE + NADP(+) = 2-OXOGLUTARATE + CO(2) + NADPH]." /note="Rv3339c, (MTV016.39c), len: 409 aa. Probable icd1, isocitrate dehydrogenase NADP-dependent (EC 1.1.1.42), highly similar to many e.g. Q9A5C8|CC2522 from Caulobacter crescentus (403 aa), FASTA scores: opt: 1972, E(): 4.6e-115, (72.45% identity in 403 aa overlap); AAF73472|ICD from Rhizobium meliloti (404 aa), FASTA scores: opt: 1968, E(): 8.1e-115, (73.2% identity in 403 aa overlap); P50215|IDH_SPHYA from Sphingomonas yanoikuyae (406 aa), FASTA scores: opt: 1964, E(): 1.4e-114, (71.45% identity in 403 aa overlap); etc. Contains PS00470 Isocitrate and isopropylmalate dehydrogenases signature. BELONGS TO THE ISOCITRATE AND ISOPROPYLMALATE DEHYDROGENASES FAMILY. TBparse score is 0.901." /codon_start=1 /transl_table=11 /product="PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP)" /protein_id="CAA17111.1" /db_xref="GI:2894249" /db_xref="GOA:P65097" /db_xref="InterPro:IPR001804" /db_xref="InterPro:IPR004790" /db_xref="UniProtKB/Swiss-Prot:P65097" /translation="MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDY YDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTI RNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFT PADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTI LKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYD GDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIA SIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNS EEFLDAIADNLEKELAN" misc_feature complement(257303..257362) /gene="icd1" /locus_tag="Rv3339c" /note="PS00470 Isocitrate and isopropylmalate dehydrogenases signature" gene 258464..259813 /gene="metC" /locus_tag="Rv3340" CDS 258464..259813 /gene="metC" /locus_tag="Rv3340" /EC_number="2.5.1.49" /function="TRANSFORMS O-ACETYLHOMOSERINE INTO L-METHIONINE [CATALYTIC ACTIVITY: O-ACETYL-L-HOMOSERINE + METHANETHIOL = L-METHIONINE + ACETATE]." /note="Rv3340, (MTV016.40), len: 449 aa. Probable metC, O-acetyl-L-homoserine sulfhydrylase (EC 4.2.99.10), highly similar to many e.g. Q9K9P2|BH2603 O-ACETYLHOMOSERINE SULFHYDRYLASE from Bacillus halodurans (430 aa), FASTA scores: opt: 1716, E(): 3.3e-97, (60.45% identity in 425 aa overlap); Q9HUE4|METY|PA5025 HOMOCYSTEINE SYNTHASE from Pseudomonas aeruginosa (425 aa), FASTA scores: opt: 1517, E(): 4.4e-85, (56.95% identity in 425 aa overlap); Q9WZY4|TM0882 O-ACETYLHOMOSERINE SULFHYDRYLASE from Thermotoga maritima (430 aa), FASTA scores: opt: 1488, E(): 2.6e-83, (55.75% identity in 418 aa overlap); BAB54344|MLR8465 O-ACETYLHOMOSERINE SULFHYDRYLASE from Rhizobium loti (Mesorhizobium loti) (426 aa), FASTA scores: opt: 1445, E(): 1.1e-80, (53.2% identity in 419 aa overlap); P50125|CYSD_EMENI O-ACETYLHOMOSERINE (THIOL)-LYASE from Emericella nidulans (Aspergillus nidulans) (437 aa), FASTA scores: opt: 1442, E(): 1.7e-80, (53.7% identity in 430 aa overlap); etc. Contains PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. COFACTOR: PYRIDOXAL PHOSPHATE. BELONGS TO THE TRANS-SULFURATION ENZYMES FAMILY. TBparse score is 0.869." /codon_start=1 /transl_table=11 /product="PROBABLE O-ACETYLHOMOSERINE SULFHYDRYLASE METC (HOMOCYSTEINE SYNTHASE) (O-ACETYLHOMOSERINE (THIOL)-LYASE) (OAH SULFHYDRYLASE) (O-ACETYL-L-HOMOSERINE SULFHYDRYLASE)" /protein_id="CAA17112.1" /db_xref="GI:2894250" /db_xref="GOA:O53390" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR006235" /db_xref="UniProtKB/TrEMBL:O53390" /translation="MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATT SYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAET FAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNT KAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSA TKYLGGHGAAIAGVIVDGGNFDWTQGRFPGFTTPDPSYHGVVFAELGPPAFALKARVQ LLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPS SPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPAS TTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFSADPQSVAAF" misc_feature 259097..259141 /gene="metC" /locus_tag="Rv3340" /note="PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site" gene 259825..260964 /gene="metA" /locus_tag="Rv3341" CDS 259825..260964 /gene="metA" /locus_tag="Rv3341" /EC_number="2.3.1.31" /function="CATALYZES ACYLATION OF L-HOMOSERINE. INVOLVED IN BIOSYNTHESIS OF METHIONINE; HTA VARIANT; FIRST STEP [CATALYTIC ACTIVITY: ACETYL-CoA + L-HOMOSERINE = CoA + O-ACETYL-L-HOMOSERINE]." /note="Rv3341, (MTV016.41), len: 379 aa. Probable metA, homoserine o-acetyltransferase (EC 2.3.1.31) (see citation below), equivalent to O32874|METX_MYCLE|META|ML0682|MLCB1779.11 HOMOSERINE O-ACETYLTRANSFERASE from Mycobacterium leprae (382 aa), FASTA scores: opt: 2263, E(): 9.2e-129, (85.0% identity in 380 aa overlap). Also highly similar to many e.g. O68640|METX_CORGL|META from Corynebacterium glutamicum (Brevibacterium flavum) (379 aa), FASTA scores: opt: 1135, E(): 5.9e-61, (48.5% identity in 371 aa overlap); Q9AAS1|CC0525 from Caulobacter crescentus (382 aa), FASTA scores: opt: 860, E(): 2e-44, (40.5% identity in 363 aa overlap); P94891|METX_LEPME from Leptospira meyeri (379 aa), FASTA scores: opt: 787, E(): 4.9e-40, (38.2% identity in 385 aa overlap); etc. BELONGS TO THE AB HYDROLASE FAMILY, HTA SUBFAMILY. TBparse score is 0.893." /codon_start=1 /transl_table=11 /product="PROBABLE HOMOSERINE O-ACETYLTRANSFERASE META (HOMOSERINE O-TRANS-ACETYLASE) (HOMOSERINE TRANSACETYLASE) (HTA)" /protein_id="CAA17113.1" /db_xref="GI:2894251" /db_xref="GOA:P0A5J8" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR006296" /db_xref="InterPro:IPR008220" /db_xref="UniProtKB/Swiss-Prot:P0A5J8" /translation="MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWG KLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNV LGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGG ARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRA PDAGLRLARRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSR FDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADL LPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR" gene 260961..261692 /locus_tag="Rv3342" CDS 260961..261692 /locus_tag="Rv3342" /EC_number="2.1.1.-" /function="CAUSES METHYLATION" /note="Rv3342, (MTV016.42), len: 243 aa. Possible methyltransferase (EC 2.1.1.-), similar to various proteins e.g. Q9I5X8|PA0558 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (255 aa), FASTA scores: opt: 496, E(): 4.4e-24, (39.85% identity in 236 aa overlap); Q9XBC9|CZA382.22c PUTATIVE RRNA METHYLASE from Amycolatopsis orientalis (259 aa), FASTA scores: opt: 473, E(): 1.2e-22, (42.45% identity in 245 aa overlap); Q9UTA8|SPAC25B8.10 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (256 aa), FASTA scores: opt: 470, E(): 1.9e-22, (35.7% identity in 238 aa overlap); and Q9UTA9|SPAC25B8.09 PUTATIVE METHYLTRANSFERASE from Schizosaccharomyces pombe (Fission yeast) (251 aa), FASTA scores: opt: 418, E(): 3.4e-19, (31.2% identity in 237 aa overlap); etc. Start uncertain. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. TBparse score is 0.878." /codon_start=1 /transl_table=11 /product="POSSIBLE METHYLTRANSFERASE (METHYLASE)" /protein_id="CAA17114.1" /db_xref="GI:2894252" /db_xref="GOA:P65348" /db_xref="InterPro:IPR000051" /db_xref="UniProtKB/Swiss-Prot:P65348" /translation="MTCSRRDMSLSFGSAVGAYERGRPSYPPEAIDWLLPAAARRVLD LGAGTGKLTTRLVERGLDVVAVDPIPEMLDVLRAALPQTVALLGTAEEIPLDDNSVDA VLVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRDERLGWVRELGEIIGRDGDPVR DRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASRSYCITSPAQVRTKTLDRVRQLLA THPALANSNGLALPYVTVCVRATLA" gene complement(261701..269272) /gene="PPE54" /locus_tag="Rv3343c" CDS complement(261701..269272) /gene="PPE54" /locus_tag="Rv3343c" /function="UNKNOWN" /note="Rv3343c, (MTV016.43c), len: 2523 aa. Member of the Mycobacterium tuberculosis PPE family, MPTR subgroup of Gly-, Asn-rich proteins. Most similar to O50379|Rv3350c|MTV004.07c|MTV004_5 from Mycobacterium tuberculosis strain H37Rv (3716 aa), FASTA scores: opt: 4672, E(): 4e-211, (44.2% identity in 3174 aa overlap); and also similar to MTV004_3, MTCY63_9, MTY13E10_17, MTY13E10_16, MTCY180_1, MTV050_1, MTCY3C7_23, MTV014_3, MTCY63_10; etc. TBparse score is 0.923." /codon_start=1 /transl_table=11 /product="PPE FAMILY PROTEIN" /protein_id="CAE55585.1" /db_xref="GI:38490357" /db_xref="GOA:Q6MWY2" /db_xref="InterPro:IPR000030" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR001434" /db_xref="InterPro:IPR002989" /db_xref="UniProtKB/TrEMBL:Q6MWY2" /translation="MSFVVMPPEINSLLIYTGAGPGPLLAAAAAWDELAAELGSAAAA FGSVTSGLVGGIWQGPSSVAMAAAAAPYAGWLSAAAASAESAAGQARAVVGVFEAALA ETVDPFVIAANRSRLVSLALSNLFGQNTPAIAAAEFDYELMWAQDVAAMLGYHTGASA AAEALAPFGSPLASLAAAAEPAKSLAVNLGLANVGLFNAGSGNVGSYNVGAGNVGSYN VGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNI GFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSG SYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGEANTGGFNPGSVNTGWLN TGDINTGVANSGDVNTGAFISGNYSNGVLWRGDYQGLLGFSSGANVLPVIPLSLDING GVGAITIEPIHILPDIPININETLYLGPLVVPPINVPAISLGVGIPNISIGPIKINPI TLWPAQNFNQTITLAWPVSSITIPQIQQVALSPSPIPTTLIGPIHINTGFSIPVTFSY STPALTLFPVGLSIPTGGPLTLTLGVTAGTEAFTIPGFSIPEQPLPLAINVIGHINAL STPAITIDNIPLNLHAIGGVGPVDIVGGNVPASPGFGNSTTAPSSGFFNTGAGGVSGF GNVGAHTSGWFNQSTQAMQVLPGTVSGYFNSGTLMSGIGNVGTQLSGMLSGGALGGNN FGLGNIGFDNVGFGNAGSSNFGLANMGIGNIGLANTGNGNIGIGLSGDNLTGFGGFNS GSENVGLFNSGTGNVGFFNSGTGNLGVFNSGSHNTGFFLTGNNINVLAPFTPGTLFTI SEIPIDLQVIGGIGPIHVQPIDIPAFDIQITGGFIGIREFTLPEITIPAIPIHVTGTV GLEGFHVNPAFVLFGQTAMAEITADPVVLPDPFITIDHYGPPLGPPGAKFPSGSFYLS ISDLQINGPIIGSYGGPGTIPGPFGATFNLSTSSLALFPAGLTVPDQTPVTVNLTGGL DSITLFPGGLAFPENPVVSLTNFSVGTGGFTVFPQGFTVDRIPVDLHTTLSIGPFPFR WDYIPPTPANGPIPAVPGGFGLTSGLFPFHFTLNGGIGPISIPTTTVVDALNPLLTVT GNLEVGPFTVPDIPIPAINFGLDGNVNVSFNAPATTLLSGLGITGSIDISGIQITNIQ TQPAQLFMSVGQTLFLFDFRDGIELNPIVIPGSSIPITMAGLSIPLPTVSESIPLNFS FGSPASTVKSMILHEILPIDVSINLEDAVFIPATVLPAIPLNVDVTIPVGPINIPIIT EPGSGNSTTTTSDPFSGLAVPGLGVGLLGLFDGSIANNLISGFNSAVGIVGPNVGLSN LGGGNVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGFGNVGLANSGLTPGLM GLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVG LFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYN TGSFNAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGD YQGLLGFSYRPAVLPQTPFLDLTLTGGLGSVVIPAIDIPAIRPEFSANVAIDSFTVPS IPIPQIDLAATTVSVGLGPITVPHLDIPRVPVTLNYLFGSQPGGPLKIGPITGLFNTP IGLTPLALSQIVIGASSSQGTITAFLANLPFSTPVVTIDEIPLLASITGHSEPVDIFP GGLTIPAMNPLSINLSGGTGAVTIPAITIGEIPFDLVAHSTLGPVHILIDLPAVPGFG NTTGAPSSGFFNSGAGGVSGFGNVGAMVSGGWNQAPSALLGGGSGVFNAGTLHSGVLN FGSGMSGLFNTSVLGLGAPALVSGLGSVGQQLSGLLASGTALHQGLVLNFGLADVGLG NVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGN IGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNS GTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSF NAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGDYQGL LGFSYTSTIIPEFTVANIHASGGAGPIIVPSIQFPAIPLDLSATGHIGGFTIPPVSIS PITVRIDPVFDLGPITVQDITIPALGLDPATGVTVGPIFSSGSIIDPFSLTLLGFINV NVPAIQTAPSEILPFTVLLSSLGVTHLTPEITIPGFHIPVDPIHVELPLSVTIGPFVS PEITIPQLPLGLALSGATPAFAFPLEITIDRIPVVLDVNALLGPINAGLVIPPVPGFG NTTAVPSSGFFNIGGGGGLSGFHNLGAGMSGVLNAISDPLLGSASGFANFGTQLSGIL NRGADISGVYNTGALGLITSALVSGFGNVGQQLAGLIYTGTGP" gene complement(269321..>270775) /gene="PE_PGRS49" /locus_tag="Rv3344c" CDS complement(269321..>270775) /gene="PE_PGRS49" /locus_tag="Rv3344c" /function="UNKNOWN" /note="Rv3344c, (MTV016.44c), len: 484 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins (see citation below). Appears to be a gene fragment, should be in-frame with following ORF, MTV016.45c, frameshift required around 49595 but could not be found on checking BAC and cosmid clones. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53557|Rv3512|MTV023.19 (1079 aa), FASTA scores: opt: 1595, E(): 1.8e-54, (52.0% identity in 544 aa overlap). TBparse score is 0.831." /codon_start=1 /transl_table=11 /product="PE-PGRS FAMILY PROTEIN" /protein_id="CAE55586.1" /db_xref="GI:38490358" /db_xref="UniProtKB/TrEMBL:Q6MWY1" /translation="AQASPAAHGGSGGAGGNGGAGSAGNGGAGGAGGNGGAGGNGGGG DAGNAGSGGNGGKGGDGVGPGSTGGAGGKGGAGANGGSSNGNARGGNAGNGGHGGAGG SGDTGGAGGAGGQGGFGGTGGSGSGIGGGAGGNGGNGGAGGTGVVLGGKGGDGGNGDH GGPATNPGSGSRGGAGGSGGNGGAGGNATGSGGKGGAGGNGGDGSFGATSGPASIGVT GAPGGNGGKGGAGGSNPNGSGGDGGKGGNGGAGGNGGSIGANSGIVGGSGGAGGAGGA GGNGSLSSGEGGKGGDGGHGGDGVGGNSSVTQGGSGGGGGAGGAGGSGFFGGKGGFGG DGGQGGPNGGGTVGTVAGGGGNGGVGGRGGDGVFAGAGGQGGLGGQGGNGGGSTGGNG GLGGAGGGGGNAPDGGFGGNGGKGGQGGIGGGTQSATGLGGDGGDGGDGGNGGNSGAK AGGAGGKGQAGQPNSGTEPGFGGDGGLGGAGATP" gene complement(270495..275111) /gene="PE_PGRS50" /locus_tag="Rv3345c" CDS complement(270495..275111) /gene="PE_PGRS50" /locus_tag="Rv3345c" /function="UNKNOWN" /note="Rv3345c, (MTV004.01c-MTV016.45c), 1538 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21, MTV023_15, MTCY493_4, MTV039_16, MTV008_46, MTV023_14, MTV023_19, MTV043_26, MTCY493_2, MTCY441_4; etc." /codon_start=1 /transl_table=11 /product="PE-PGRS FAMILY PROTEIN" /protein_id="CAE55587.1" /db_xref="GI:38490359" /db_xref="InterPro:IPR000084" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR002952" /db_xref="UniProtKB/TrEMBL:Q6MWY0" /translation="MVMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAA GDEVSAAIAALFGTHAQEYQALSARVATFHEQFVRSLTAAGSAYATAEAANASPLQAL EQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAGGLLWGNGGNGGSGAAGQVGG PGGAAGLFGNGGSGGSGGAGAAGGVGGSGGWLNGNGGAGGAGGTGANGGAGGNAWLFG AGGSGGAGTNGGVGGSGGFVYGNGGAGGIGGIGGIGGNGGDAGLFGNGGAGGAGAAGL PGAAGLNGGDGSDGGNGGTGGNGGRGGLLVGNGGAGGAGGVGGDGGKGGAGDPSFAVN NGAGGNGGHGGNPGVGGAGGAGGLLAGAHGAAGATPTSGGNGGDGGIGATANSPLQAG GAGGNGGHGGLVGNGGTGGAGGAGHAGSTGATGTALQPTGGNGTNGGAGGHGGNGGNG GAQHGDGGVGGKGGAGGSGGAGGNGFDAATLGSPGADGGMGGNGGKGGDGGKAGDGGA GAAGDVTLAVNQGAGGDGGNGGEVGVGGKGGAGGVSANPALNGSAGANGTAPTSGGNG GNGGAGATPTVAGENGGAGGNGGHGGSVGNGGAGGAGGNGVAGTGLALNGGNGGNGGI GGNGGSAAGTGGDGGKGGNGGAGANGQDFSASANGANGGQGGNGGNGGIGGKGGDAFA TFAKAGNGGAGGNGGNVGVAGQGGAGGKGAIPAMKGATGADGTAPTSGGDGGNGGNGA SPTVAGGNGGDGGKGGSGGNVGNGGNGGAGGNGAAGQAGTPGPTSGDSGTSGTDGGAG GNGGAGGAGGTLAGHGGNGGKGGNGGQGGIGGAGERGADGAGPNANGANGENGGSGGN GGDGGAGGNGGAGGKAQAAGYTDGATGTGGDGGNGGDGGKAGDGGAGENGLNSGAMLP GGGTVGNPGTGGNGGNGGNAGVGGTGGKAGTGSLTGLDGTDGITPNGGNGGNGGNGGK GGTAGNGSGAAGGNGGNGGSGLNGGDAGNGGNGGGALNQAGFFGTGGKGGNGGNGGAG MINGGLGGFGGAGGGGAVDVAATTGGAGGNGGAGGFASTGLGGPGGAGGPGGAGDFAS GVGGVGGAGGDGGAGGVGGFGGQGGIGGEGRTGGNGGSGGDGGGGISLGGNGGLGGNG GVSETGFGGAGGNGGYGGPGGPEGNGGLGGNGGAGGNGGVSTTGGDGGAGGKGGNGGD GGNVGLGGDAGSGGAGGNGGIGTDAGGAGGAGGAGGNGGSSKSTTTGNAGSGGAGGNG GTGLNGAGGAGGAGGNAGVAGVSFGNAVGGDGGNGGNGGHGGDGTTGGAGGKGGNGSS GAASGSGVVNVTAGHGGNGGNGGNGGNGSAGAGGQGGAGGSAGNGGHGGGATGGDGGN GGNGGNSGNSTGVAGLAGGAAGAGGNGGGTSSAAGHGGSGGSGGSGTTGGAGAAGGNG GAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQRRRRWCRWQRRCRRQRWRWRCRQR RLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRRFQQRQRSRWQRR" gene complement(275535..275792) /locus_tag="Rv3346c" CDS complement(275535..275792) /locus_tag="Rv3346c" /function="UNKNOWN" /note="Rv3346c, (MTV004.02c), len: 85 aa. Conserved hypothetical protein, highly similar to mycobacterium hypothetical proteins O50384|Rv3355c|MTV004.12c from strain H37Rv (97 aa), FASTA scores: opt: 413, E(): 4.6e-23, (85.55% identity in 97 aa overlap); O32878|MLCB1779.16c|ML0675 from Mycobacterium leprae (91 aa), FASTA scores: opt: 349, E(): 1.7e-18, (67.35% identity in 95 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15731.1" /db_xref="GI:2661625" /db_xref="UniProtKB/TrEMBL:O50377" /translation="MTVRAVLRRTVGAQWPILAGVNFWRRGALLIGIGVGVAAVLRLV LSEERAGLLVVRSKGIDFVTTVTVAAAMVYIASTIDPLGTG" repeat_unit 275535..275741 /note="207 bp imperfect direct repeat 1, 199/207 bp identical to second copy at 3769514..3769720" repeat_unit 275739..275847 /note="109 bp imperfect direct repeat 1, 95/109 bp identical to second copy at 3769754..3769862" repeat_unit 275845..275942 /note="98 bp imperfect direct repeat 1, 82/98 bp identical to the second copy at 3770994..3771091" gene complement(276048..285521) /gene="PPE55" /locus_tag="Rv3347c" CDS complement(276048..285521) /gene="PPE55" /locus_tag="Rv3347c" /function="UNKNOWN" /note="Rv3347c, (MTV004.03c), len: 3157 aa. Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-, Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16, MTCY63_9, MTY13E10_17, MTCY180_1; etc." /codon_start=1 /transl_table=11 /product="PPE FAMILY PROTEIN" /protein_id="CAE55588.1" /db_xref="GI:38490360" /db_xref="InterPro:IPR000030" /db_xref="InterPro:IPR002989" /db_xref="UniProtKB/TrEMBL:Q6MWX9" /translation="MNFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVS FGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAQAVAVAGQARAAVAAFEAALA ATVDPAAVAVNRMAMRALAMSNLLGQNAAAIAAVEAEYELMWAADVAAMAGYHSGASA AAAALPAFSPPAQALGGGVGAFLNALFAGPAKMLRLNAGLGNVGNYNVGLGNVGIFNL GAANVGAQNLGAANAGSGNFGFGNIGNANFGFGNSGLGLPPGMGNIGLGNAGSSNYGL ANLGVGNIGFANTGSNNIGIGLTGDNLTGIGGLNSGTGNLGLFNSGTGNIGFFNSGTG NFGVFNSGSYNTGVGNAGTASTGLFNVGGFNTGVANVGSYNTGSFNAGNTNTGGFNPG NVNTGWLNTGNTNTGIANSGNVNTGAFISGNFSNGVLWRGDYEGLWGLSGGSTIPAIP IGLELNGGVGPITVLPIQILPTIPLNIHQTFSLGPLVVPDIVIPAFGGGTAIPISVGP ITISPITLFPAQNFNTTFPVGPFFGLGVVNISGIEIKDLAGNVTLQLGNLNIDTRINQ SFPVTVNWSTPAVTIFPNGISIPNNPLALLASASIGTLGFTIPGFTIPAAPLPLTIDI DGQIDGFSTPPITIDRIPLNLGASVTVGPILINGVNIPATPGFGNTTTAPSSGFFNSG DGGVSGFGNFGAGSSGWWNQAQTEVAGAGSGFANFGSLGSGVLNFGSGVSGLYNTGGL PPGTPAVVSGIGNVGEQLSGLSSAGTALNQSLIINLGLADVGSVNVGFGNVGDFNLGA ANIGDLNVGLGNVGGGNVGFGNIGDANFGLGNAGLAAGLAGVGNIGLGNAGSGNVGFG NMGVGNIGFGNTGTNNLGIGLTGDNQTGIGGLNSGAGNIGLFNSGTGNVGLFNSGTGN FGLFNSGSFNTGIGNGGTGSTGLFNAGNFNTGVANPGSYNTGSFNVGDTNTGGFNPGS INTGWFNTGNANTGVANSGNVDTGALMSGNFSNGILWRGNFEGLFGLNVGITIPEFPI HWTSTGGIGPIIIPDTTILPPIHLGLTGQANYGFAVPDIPIPAIHIDFDGAADAGFTA PATTLLSALGITGQFRFGPITVSNVQLNPFNVNLKLQFLHDAFPNEFPDPTISVQIQV AIPLTSATLGGLALPLQQTIDAIELPAISFSQSIPIDIPPIDIPASTINGISMSEVVP IDVSVDIPAVTITGTRIDPIPLNFDVLSSAGPINISIIDIPALPGFGNSTELPSSGFF NTGGGGGSGIANFGAGVSGLLNQASSPMVGTLSGLGNAGSLASGVLNSGVDISGMFNV STLGSAPAVISGFGNLGNHVSGVSIDGLLAMLTSGGSGGSGQPSIIDAAIAELRHLNP LNIVNLGNVGSYNLGFANVGDVNLGAGNLGNLNLGGGNLGGQNLGLGNLGDGNVGFGN LGHGNVGFGNSGLGALPGIGNIGLGNAGSNNVGFGNMGLGNIGFGNTGTNNLGIGLTG DNQTGFGGLNSGAGNLGLFNSGTGNIGFFNTGTGNWGLFNSGSYNTGIGNSGTGSTGL FNAGSFNTGLANAGSYNTGSLNAGNTNTGGFNPGNVNTGWFNAGHTNTGGFNTGNVNT GAFNSGSFNNGALWTGDHHGLVGFSYSIEITGSTLVDINETLNLGPVHIDQIDIPGMS LFDIHELVNIGPFRIEPIDVPAVVLDIHETMVIPPIVFLPSMTIGGQTYTIPLDTPPA PAPPPFRLPLLFVNALGDNWIVGASNSTGMSGGFVTAPTQGILIHTGPSSATTGSLAL TLPTVTIPTITTSPIPLKIDVSGGLPAFTLFPGGLNIPQNAIPLTIDASGVLDPITIF PGGFTIDPLPLSLALNISVPDSSVPIIIVPPTPGFGNATATPSSGFFNSGAGGVSGFG NFGAGSSGWWNQAHAALAGAGSGVLNVGTLNSGVLNVGSGISGLYNTAIVGLGTPALV SGAGNVGQQLSGVLAAGTALTQSPIINLGLADVGNYNLGLGNVGDFNLGAANLGDLNL GLGNIGNANVGFGNIGHGNVGFGNSGLGAALGIGNIGLGNAGSTNVGLANMGVGNIGF ANTGTNNLGIGLTGDNQTGIGGLNSGAGNIGLFNSGTGNIGFFNSGTGNWGLFNSGSF NTGIGNSGTGSTGLFNAGGFTTGLANAGSYNTGSFNVGDTNTGGFNPGSINTGWFNTG NANTGIANSGNVDTGALMSGNFSNGILWRGNYEGLFSYSYSLDVPRITILDAHFTGAF GPVVVPPIPVLAINAHLTGNAAMGAFTIPQIDIPALNPNVTGSVGFGPIAVPSVTIPA LTAARAVLDMAASVGATSEIEPFIVWTSSGAIGPTWYSVGRIYNAGDLFVGGNIISGI PTLSTTGPVHAVFNAASQAFNTPALNIHQIPLGFQVPGSIDAITLFPGGLTFPANSLL NLDVFVGTPGATIPAITFPEIPANADGELYVIAGDIPLINIPPTPGIGNTTTVPSSGF FNTGAGGGSGFGNFGANMSGWWNQAHTALAGAGSGIANVGTLHSGVLNLGSGLSGIYN TSTLPLGTPALVSGLGNVGDHLSGLLASNVGQNPITIVNIGLANVGNGNVGLGNIGNL NLGAANIGDVNLGFGNIGDVNLGFGNIGGGNVGFGNIGDANFGFGNSGLAAGLAGMGN IGLGNAGSGNVGWANMGLGNIGFGNTGTNNLGIGLTGDNQSGIGGLNSGTGNIGLFNS GTGNIGFFNSGTANFGLFNSGSYNTGIGNSGVASTGLVNAGGFNTGVANAGSYNTGSF NAGDTNTGGFNPGSTNTGWFNTGNANTGVANAGNVNTGALITGNFSNGILWRGNYEGL AGFSFGYPIPLFPAVGADVTGDIGPATIIPPIHIPSIPLGFAAIGHIGPISIPNIAIP SIHLGIDPTFDVGPITVDPITLTIPGLSLDAAVSEIRMTSGSSSGFKVRPSFSFFAVG PDGMPGGEVSILQPFTVAPINLNPTTLHFPGFTIPTGPIHIGLPLSLTIPGFTIPGGT LIPQLPLGLGLSGGTPPFDLPTVVIDRIPVELHASTTIGPVSLPIFGFGGAPGFGNDT TAPSSGFFNTGGGGGSGFSNSGSGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGA GISGVYNTGTLGLVTSAFVSGFMNVGQQLSGLLFAGTGP" gene 286102..286593 /locus_tag="Rv3348" CDS 286102..286593 /locus_tag="Rv3348" /function="POSSIBLY INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS1608'." /note="Rv3348, (MTV004.04), len: 163 aa. Probable transposase, partially similar to several insertion elements e.g. P19834|YI11_STRCL INSERTION ELEMENT IS116 HYPOTHETICAL 44.8 KDA PROTEIN (SIMILAR TO IS900 OF MYCOBACTERIUM PARATUBERCULOSIS) from Streptomyces clavuligerus (399 aa), FASTA scores: opt: 146, E(): 0.016, (29.1% identity in 158 aa overlap)." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA15733.1" /db_xref="GI:2661627" /db_xref="GOA:P96234" /db_xref="InterPro:IPR002525" /db_xref="UniProtKB/TrEMBL:P96234" /translation="MTAENPGRSRRTLVGIDAAITACHHIAIRDDVGARSIRFSVEPT LAGLRTLTDKLSGYDDIDATVEPTSMTWLPLTIAVENAGDTMHMAGARHCARLRGAIV GKSKSDVIDAEVLTRASEVFDLTPLTLPTPAQLALRRSVIRRAGAVIDANRSWRRLMS LAR" repeat_region 286102..286590 /note="IS1608', len: 489 bp. Insertion sequence IS1608'." /insertion_seq="IS1608'" gene complement(286630..287370) /locus_tag="Rv3349c" CDS complement(286630..287370) /locus_tag="Rv3349c" /function="POSSIBLY INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS1561'." /note="Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 PUTATIVE TRANSPOSASE from NOCARDIA ASTEROIDES (377 aa), FASTA scores: opt: 288, E(): 8.3e-11, (48.5% identity in 97 aa overlap); and others." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA15734.1" /db_xref="GI:3242263" /db_xref="GOA:Q93IG7" /db_xref="InterPro:IPR002560" /db_xref="UniProtKB/TrEMBL:Q93IG7" /translation="MAIDPAAAYASAIRTPGLLPNAKLVVDHFHVTTLANDALTAVRR RVTWAFHDRRGRKIDPQWANRRRLLTARERLSDKSFAKMRNRINAVDPRAQILSAWIA KEELRTLLSTVRTGGDPHLARHHLHRFLPGASTRRSPNCSPWPPPLTSHPRSTPSWSP ASPTRASVVGEVAEMLGDIDGQCVQVEVPVPERGPAGCGGLDGLGRAGVSATPRVCAA MTAVNVAGRCAGQQADVGPTPQHRCRGR" repeat_region complement(286633..287370) /note="IS1561', len: 738 bp. Insertion sequence IS1561'." /insertion_seq="IS1561'" gene complement(288289..299439) /gene="PPE56" /locus_tag="Rv3350c" CDS complement(288289..299439) /gene="PPE56" /locus_tag="Rv3350c" /function="UNKNOWN" /note="Rv3350c, (MTV004.07c), len: 3716 aa. Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc." /codon_start=1 /transl_table=11 /product="PPE FAMILY PROTEIN" /protein_id="CAE55589.1" /db_xref="GI:38490361" /db_xref="InterPro:IPR000030" /db_xref="InterPro:IPR002989" /db_xref="UniProtKB/TrEMBL:Q6MWX8" /translation="MEFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVS FGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAAAEAVAGQARVVVGVFEAALA ATVDPALVAANRARLVALAVSNLLGQNTPAIAAAEAEYELMWAADVAAMAGYHSGASA AAAALPAFSPPAQALGGGVGAFLTALFASPAKALSLNAGLGNVGNYNVGLGNVGVFNL GAGNVGGQNLGFGNAGGTNVGFGNLGNGNVGFGNSGLGAGLAGLGNIGLGNAGSSNYG FANLGVGNIGFGNTGTNNVGVGLTGNHLTGIGGLNSGTGNIGLFNSGTGNVGFFNSGT GNFGVFNSGNYNTGVGNAGTASTGLFNAGNFNTGVVNVGSYNTGSFNAGDTNTGGFNP GGVNTGWLNTGNTNTGIANSGNVNTGAFISGNFNNGVLWVGDYQGLFGVSAGSSIPAI PIGLVLNGDIGPITIQPIPILPTIPLSIHQTVNLGPLVVPDIVIPAFGGGIGIPINIG PLTITPITLFAQQTFVNQLPFPTFSLGKITIPQIQTFDSNGQLVSFIGPIVIDTTIPG PTNPQIDLTIRWDTPPITLFPNGISAPDNPLGLLVSVSISNPGFTIPGFSVPAQPLPL SIDIEGQIDGFSTPPITIDRIPLTVGGGVTIGPITIQGLHIPAAPGVGNTTTAPSSGF FNSGAGGVSGFGNVGAGSSGWWNQAPSALLGAGSGVGNVGTLGSGVLNLGSGISGFYN TSVLPFGTPAAVSGIGNLGQQLSGVSAAGTTLRSMLAGNLGLANVGNFNTGFGNVGDV NLGAANIGGHNLGLGNVGDGNLGLGNIGHGNLGFANLGLTAGAAGVGNVGFGNAGINN YGLANMGVGNIGFANTGTGNIGIGLVGDHRTGIGGLNSGIGNIGLFNSGTGNVGFFNS GTGNFGIGNSGRFNTGIGNSGTASTGLFNAGSFSTGIANTGDYNTGSFNAGDTNTGGF NPGGINTGWFNTGHANTGLANAGTFGTGAFMTGDYSNGLLWRGGYEGLVGVRVGPTIS QFPVTVHAIGGVGPLHVAPVPVPAVHVEITDATVGLGPFTVPPISIPSLPIASITGSV DLAANTISPIRALDPLAGSIGLFLEPFRLSDPFITIDAFQVVAGVLFLENIIVPGLTV SGQILVTPTPIPLTLNLDTTPWTLFPNGFTIPAQTPVTVGMEVANDGFTFFPGGLTFP RASAGVTGLSVGLDAFTLLPDGFTLDTVPATFDGTILIGDIPIPIIDVPAVPGFGNTT TAPSSGFFNTGGGGGSGFANVGAGTSGWWNQGHDVLAGAGSGVANAGTLSSGVLNVGS GISGWYNTSTLGAGTPAVVSGIGNLGQQLSGFLANGTVLNRSPIVNIGWADVGAFNTG LGNVGDLNWGAANIGAQNLGLGNLGSGNVGFGNIGAGNVGFANSGPAVGLAGLGNVGL SNAGSNNWGLANLGVGNIGLANTGTGNIGIGLVGDYQTGIGGLNSGSGNIGLFNSGTG NVGFFNTGTGNFGLFNSGSFNTGIGNSGTGSTGLFNAGNFNTGIANPGSYNTGSFNVG DTNTGGFNPGDINTGWFNTGIMNTGTRNTGALMSGTDSNGMLWRGDHEGLFGLSYGIT IPQFPIRITTTGGIGPIVIPDTTILPPLHLQITGDADYSFTVPDIPIPAIHIGINGVV TVGFTAPEATLLSALKNNGSFISFGPITLSNIDIPPMDFTLGLPVLGPITGQLGPIHL EPIVVAGIGVPLEIEPIPLDAISLSESIPIRIPVDIPASVIDGISMSEVVPIDASVDI PAVTITGTTISAIPLGFDIRTSAGPLNIPIIDIPAAPGFGNSTQMPSSGFFNTGAGGG SGIGNLGAGVSGLLNQAGAGSLVGTLSGLGNAGTLASGVLNSGTAISGLFNVSTLDAT TPAVISGFSNLGDHMSGVSIDGLIAILTFPPAESVFDQIIDAAIAELQHLDIGNALAL GNVGGVNLGLANVGEFNLGAGNVGNINVGAGNLGGSNLGLGNVGTGNLGFGNIGAGNF GFGNAGLTAGAGGLGNVGLGNAGSGSWGLANVGVGNIGLANTGTGNIGIGLTGDYRTG IGGLNSGTGNLGLFNSGTGNIGFFNTGTGNFGLFNSGSYSTGVGNAGTASTGLFNAGN FNTGLANAGSYNTGSLNVGSFNTGGVNPGTVNTGWFNTGHTNTGLFNTGNVNTGAFNS GSFNNGALWTGDYHGLVGFSFSIDIAGSTLLDLNETLNLGPIHIEQIDIPGMSLFDVH EIVEIGPFTIPQVDVPAIPLEIHESIHMDPIVLVPATTIPAQTRTIPLDIPASPGSTM TLPLISMRFEGEDWILGSTAAIPNFGDPFPAPTQGITIHTGPGPGTTGELKISIPGFE IPQIATTRFLLDVNISGGLPAFTLFAGGLTIPTNAIPLTIDASGALDPITIFPGGYTI DPLPLHLALNLTVPDSSIPIIDVPPTPGFGNTTATPSSGFFNSGAGGVSGFGNVGSNL SGWWNQAASALAGSGSGVLNVGTLGSGVLNVGSGVSGIYNTSVLPLGTPAVLSGLGNV GHQLSGVSAAGTALNQIPILNIGLADVGNFNVGFGNVGDVNLGAANLGAQNLGLGNVG TGNLGFANVGHGNIGFGNSGLTAGAAGLGNTGFGNAGSANYGFANQGVRNIGLANTGT GNIGIGLVGDNLTGIGGLNSGAGNIGLFNSGTGNIGFFNSGTGNFGIGNSGSFNTGIG NSGTGSTGLFNAGSFNTGVANAGSYNTGSFNAGDTNTGGFNPGTINTGWFNTGHTNTG IANSGNVGTGAFMSGNFSNGLLWRGDHEGLFSLFYSLDVPRITIVDAHLDGGFGPVVL PPIPVPAVNAHLTGNVAMGAFTIPQIDIPALTPNITGSAAFRIVVGSVRIPPVSVIVE QIINASVGAEMRIDPFEMWTQGTNGLGITFYSFGSADGSPYATGPLVFGAGTSDGSHL TISASSGAFTTPQLETGPITLGFQVPGSVNAITLFPGGLTFPATSLLNLDVTAGAGGV DIPAITWPEIAASADGSVYVLASSIPLINIPPTPGIGNSTITPSSGFFNAGAGGGSGF GNFGAGTSGWWNQAHTALAGAGSGFANVGTLHSGVLNLGSGVSGIYNTSTLGVGTPAL VSGLGNVGHQLSGLLSGGSAVNPVTVLNIGLANVGSHNAGFGNVGEVNLGAANLGAHN LGFGNIGAGNLGFGNIGHGNVGVGNSGLTAGVPGLGNVGLGNAGGNNWGLANVGVGNI GLANTGTGNIGIGLTGDYQTGIGGLNSGAGNLGLFNSGAGNVGFFNTGTGNFGLFNSG SFNTGVGNSGTGSTGLFNAGSFNTGVANAGSYNTGSFNVGDTNTGGFNPGSINTGWLN AGNANTGVANAGNVNTGAFVTGNFSNGILWRGDYQGLAGFAVGYTLPLFPAVGADVSG GIGPITVLPPIHIPPIPVGFAAVGGIGPIAIPDISVPSIHLGLDPAVHVGSITVNPIT VRTPPVLVSYSQGAVTSTSGPTSEIWVKPSFFPGIRIAPSSGGGATSTQGAYFVGPIS IPSGTVTFPGFTIPLDPIDIGLPVSLTIPGFTIPGGTLIPTLPLGLALSNGIPPVDIP AIVLDRILLDLHADTTIGPINVPIAGFGGAPGFGNSTTLPSSGFFNTGAGGGSGFSNT GAGMSGLLNAMSDPLLGSASGFANFGTQLSGILNRGAGISGVYNTGALGVVTAAVVSG FGNVGQQLSGLLFTGVGP" gene complement(299683..300477) /locus_tag="Rv3351c" CDS complement(299683..300477) /locus_tag="Rv3351c" /function="UNKNOWN" /note="Rv3351c, (MTV004.08c), len: 264 aa. Hypothetical protein, highly similar to C-terminal region (aa 292-479) of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from Mycobacterium tuberculosis (479 aa), FASTA scores: opt: 699, E(): 1.7e-36, (54.75% identity in 190 aa overlap). Shows some similarity to Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 192, E(): 9.1e-05, (27.9% identity in 154 aa overlap); and P71091|YGAK HYPOTHETICAL 54.4 KDA PROTEIN from Bacillus subtilis (480 aa), FASTA scores: opt: 174, E(): 0.0014, (26.5% identity in 166 aa overlap). Note that the two upstream ORFs Rv3352c and Rv3353c also show similarity to Rv0063 (MTV030_7). Sequence was checked but no errors found." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15736.1" /db_xref="GI:2661629" /db_xref="UniProtKB/TrEMBL:O50380" /translation="MLASCPARSGAAVADAIKSAVGVQPSGVEHKTLRRMDLVRYLAG GHTTYPPEGFVAGSDVIGTTNPAAAQAIVAAIGTWPPAAGRASALIDSLGGAVGDMDP EGSAFPWCRQSAVVQWYVNTPSDGQVATANKWLSDAHHAVQHFSVGGYVNYLEANAAA SQYFGANLSRLTTVRRKYDPDRIMYSGLDFSTRQVAERLLPALGFRVRFGVLVIRCAL CTDTVKRLGTLPNLTWSRLKVNVAVTQEQAGVMDLPALPVRRTPRR" gene complement(300559..300930) /locus_tag="Rv3352c" CDS complement(300559..300930) /locus_tag="Rv3352c" /EC_number="1.-.-.-" /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR METABOLISM." /note="Rv3352c, (MTV004.09c), len: 123 aa. Possible oxidoreductase (EC 1.-.-.-), similar to part of several oxidoreductases (and hypothetical proteins) from diverse organisms e.g. Q9KYD6|SCD72A.20 PUTATIVE LIPOPROTEIN (FRAGMENT) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 348, E(): 7.9e-15, (51.0% identity in 102 aa overlap); BAB53081|MLR6875 PROBABLE OXIDOREDUCTASE from Rhizobium loti (Mesorhizobium loti) (479 aa), FASTA scores: opt: 262, E(): 2.3e-09, (53.85% identity in 78 aa overlap); O94206|OX1 OXIDOREDUCTASE from Claviceps purpurea (Ergot fungus) (483 aa), FASTA scores: opt: 245, E(): 2.7e-08, (42.6% identity in 115 aa overlap); Q9KHK2|ENCM PUTATIVE FAD-DEPENDENT OXYGENASE ENCM from Streptomyces maritimus (464 aa), FASTA scores: opt: 238, E(): 7.2e-08, (43.95% identity in 91 aa overlap); etc. Also highly similar to part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE (479 aa), FASTA scores: opt: 599, E(): 1.6e-30, (71.55% identity in 123 aa overlap); and to other Mycobacterium tuberculosis proteins e.g. Rv3353c and Rv3351c. All show similarity to a family of oxidoreductases in Mycobacterium tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found." /codon_start=1 /transl_table=11 /product="POSSIBLE OXIDOREDUCTASE" /protein_id="CAA15737.1" /db_xref="GI:2661630" /db_xref="GOA:O50381" /db_xref="InterPro:IPR006094" /db_xref="UniProtKB/TrEMBL:O50381" /translation="MSAATDLYAVHQALAGESRAIPTGSCPTVGVAGLTLGGGLGADS RHAGLTCDALKSATVVLPGGDAVSASADDHAELFWALRGGGGGNFGVTTSMTFARFPT ADCDVVRVDFAPSAAAQVLVG" gene complement(301073..301333) /locus_tag="Rv3353c" CDS complement(301073..301333) /locus_tag="Rv3353c" /function="UNKNOWN" /note="Rv3353c, (MTV004.10c), len: 86 aa. Hypothetical protein, showing some similarity to Q9X5Q4|MITR MITR PROTEIN from Streptomyces lavendulae (514 aa), FASTA scores: opt: 134, E(): 0.09, (29.5% identity in 78 aa overlap); and weak to Q49720|B1549_C3_218 from Mycobacterium leprae (222 aa), FASTA scores: opt: 99, E(): 8.8, (32.9% identity in 76 aa overlap). But highly similar to N-terminal part of O53608|Rv0063|MTV030.06 OXIDOREDUCTASE from Mycobacterium tuberculosis (479 aa), FASTA scores: opt: 305, E(): 4.9e-13, (52.9% identity in 87 aa overlap); and some similarity can be found with Rv3352c and Rv3351c. All show similarity to a family of oxidoreductases in Mycobacterium tuberculosis, suggesting that frameshift mutations may have occurred. Sequence has been checked but no errors were found. Start changed since original submission." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15738.2" /db_xref="GI:38490362" /db_xref="UniProtKB/TrEMBL:O50382" /translation="MSRQTFLRGAVGAPATSAVFPTILARATPGDGWASLASSIGGQV LLPANGRAFTSGKQIFNSNYSGLNPAAVVTVASQADVRKAVS" gene 301448..301837 /locus_tag="Rv3354" CDS 301448..301837 /locus_tag="Rv3354" /function="UNKNOWN" /note="Rv3354, (MTV004.11), len: 129 aa. Conserved hypothetical protein, equivalent (but shorter 29 aa) to Q9CCM4|ML0676 HYPOTHETICAL PROTEIN from Mycobacterium leprae (158 aa), FASTA scores: opt: 467, E(): 3.3e-21, (55.9% identity in 127 aa overlaps). Highly similar to O33192|LPRJ|Rv1690|MTCI125.12 HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (127 aa), FASTA scores: opt: 329, E(): 4.7e-13, (46.95% identity in 115 aa overlap); and also similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O07222|Rv1810|MTCY16F9.04c (118 aa), FASTA scores: opt: 195, E(): 4.2e-05, (37.15% identity in 113 aa overlap); MTCI125_11, MTCY16F9_4, MTV049_25." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15739.1" /db_xref="GI:2661632" /db_xref="InterPro:IPR007969" /db_xref="UniProtKB/TrEMBL:O50383" /translation="MNLRRHQTLTLRLLAASAGILSAAAFAAPAQANPVDDAFIAALN NAGVNYGDPVDAKALGQSVCPILAEPGGSFNTAVASVVARAQGMSQDMAQTFTSIAIS MYCPSVMADVASGNLPALPDMPGLPGS" gene complement(301851..302144) /locus_tag="Rv3355c" CDS complement(301851..302144) /locus_tag="Rv3355c" /function="UNKNOWN" /note="Rv3355c, (MTV004.12c), len: 97 aa. Hypothetical protein, equivalent to O32878|MLCB1779.16c|ML0675 HYPOTHETICAL 9.6 KDA PROTEIN from Mycobacterium leprae (91 aa), FASTA scores: opt: 439, E(): 3.9e-23, (78.9% identity in 90 aa overlap). Identical, but with a gap, to O50377|Rv3346c|MTV004.02c HYPOTHETICAL 8.9 KDA PROTEIN from Mycobacterium tuberculosis (85 aa), FASTA scores: opt: 413, E(): 2.1e-21, (85.55% identity in 97 aa overlap). Also some similarity to other proteins e.g. Q9K3J5|SC2A6.10 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (178 aa), FASTA scores: opt: 147, E(): 0.003, (31.25% identity in 80 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15740.1" /db_xref="GI:2661633" /db_xref="UniProtKB/TrEMBL:O50384" /translation="MTVRAVFRRTVGAQWPILLVGSIFAVGFVLAGANFWRRGALLIG IGVGVAAVLRLVLSEERAGLLVVRSKGIDFVTTVTVAAAMVYIASTIDPLGTG" repeat_unit 301851..302057 /note="207 bp imperfect direct repeat 2, 199/207 bp identical to first copy at 3743198..3743404" repeat_unit 302091..302199 /note="109 bp imperfect direct repeat 2, 95/109 bp identical to first copy at 3743402..3743510" gene complement(302141..302986) /gene="folD" /locus_tag="Rv3356c" CDS complement(302141..302986) /gene="folD" /locus_tag="Rv3356c" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="NECESSARY FOR THE BIOSYNTHESIS OF PURINES, THYMYDYLATE, METHIONINE, HISTIDINE, PANTOTHENATE, AND FORMYL TRNA-MET [CATALYTIC ACTIVITY: 5,10-METHYLENETETRAHYDROFOLATE + NADP(+) = 5,10-METHENYLTETRAHYDROFOLATE + NADPH] [CATALYTIC ACTIVITY: 5,10-METHENYLTETRAHYDROFOLATE + H(2)O = 10-FORMYLTETRAHYDROFOLATE]." /experiment="experimental evidence, no additional details recorded" /note="Rv3356c, (MTV004.13c), len: 281 aa. Probable folD, bifunctional enzyme include methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9), equivalent to O32879|FOLD|ML0674 METHYLENETETRAHYDROFOLATE DEHYDROGENASE (PUTATIVE METHYLENETETRAHYDROFOLATE DEHYDROGENASE/METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE) from Mycobacterium leprae (282 aa), FASTA scores: opt: 1624, E(): 1.2e-93, (86.45% identity in 281 aa overlap). Also similar to many others e.g. Q9K3J6|FOLD from Streptomyces coelicolor (284 aa), FASTA scores: opt: 1223, E(): 9.5e-69, (66.65% identity in 279 aa overlap); Q9K966|FOLD from Bacillus halodurans (279 aa), FASTA scores: opt: 886, E(): 7.7e-48, (47.15% identity in 280 aa overlap); P54382|FOLD_BACSU from Bacillus subtilis (283 aa), FASTA scores: opt: 820, E(): 9.7e-44, (45.7% identity in 280 aa overlap); P51696|FOLD_PHOPO from Photobacterium phosphoreum (285 aa), FASTA scores: opt: 778, E(): 4e-41, (44.9% identity in 283 aa overlap); P24186|FOLD_ECOLI|ADS|B0529 from Escherichia coli (287 aa), FASTA scores: opt: 741, E(): 0,44.4, (44.4% identity in 277 aa overlap); etc. Also highly similar to MLCB1779_9 from Mycobacterium leprae cosmid B1779 (282 aa) (86.5% identity in 281 aa overlap). SIMILAR TO OTHER DEHYDROGENASE/CYCLOHYDROLASE ENZYMES OR DOMAINS." /codon_start=1 /transl_table=11 /product="PROBABLE BIFUNCTIONAL PROTEIN FOLD: METHYLENETETRAHYDROFOLATE DEHYDROGENASE + METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE" /protein_id="CAA15741.1" /db_xref="GI:2661634" /db_xref="GOA:O50385" /db_xref="InterPro:IPR000672" /db_xref="UniProtKB/TrEMBL:O50385" /translation="MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDP GSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPK HLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAH VVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLT ADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVE LAERR" gene 303110..303385 /locus_tag="Rv3357" CDS 303110..303385 /locus_tag="Rv3357" /function="UNKNOWN" /note="Rv3357, (MTV004.14), len: 91 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9Z4V7|YU1E_STRCO (alias CAC37261|SCBAC17D6.02) ORFU1E (BELONGS TO THE PHD/YEFM FAMILY) from Streptomyces coelicolor (87 aa), FASTA scores: opt: 344, E(): 1.9e-17, (62.05% identity in 87 aa overlap); P46147|YEFM_ECOLI|B2017 from Escherichia coli strain K12 (83 aa), FASTA scores: opt: 215, E(): 1.6e-08, (50.0% identity in 72 aa overlap); BAB58570|SAV2408 from Staphylococcus aureus subsp. aureus Mu50 (83 aa), FASTA scores: opt: 161, E(): 8.8e-05, (39.95% identity in 77 aa overlap); Q9Z5W8 PUTATIVE PHD PROTEIN from Francisella novicid (85 aa), FASTA scores: opt: 143, E(): 0.0016, (28.9% identity in 83 aa overlap); etc. Also similar to Rv1247c|MTV006.19c (89 aa) (36.9% identity in 84 aa overlap). SEEMS TO BELONG TO THE PHD/YEFM FAMILY." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15742.1" /db_xref="GI:2661635" /db_xref="InterPro:IPR003756" /db_xref="InterPro:IPR006442" /db_xref="UniProtKB/Swiss-Prot:P65067" /translation="MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYD AWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSVDELREMAGGEE" repeat_unit 303331..303428 /note="98 bp imperfect direct repeat 2, 82/98 bp identical to the first copy at 3743508..3743605" gene 303382..303639 /locus_tag="Rv3358" CDS 303382..303639 /locus_tag="Rv3358" /function="UNKNOWN" /note="Rv3358, (MTV004.15), len: 85 aa. Conserved hypohetical protein, highly similar to other hypohetical proteins e.g. Q9Z4V8|SCBAC17D6.03 from Streptomyces coelicolor (84 aa), FASTA scores: opt: 393, E(): 1.1e-21, (59.75% identity in 82 aa overlap); P56605|YOEB_ECOLI from Escherichia coli (84 aa), FASTA scores: opt: 305, E(): 2.2e-15, (49.35% identity in 77 aa overlap); Q9Z5W7 PUTATIVE DOC PROTEIN from Francisella novicida (68 aa), FASTA scores: opt: 253, E(): 9.6e-12, (51.6% identity in 62 aa overlap); BAB58569|SAV2407 from Staphylococcus aureus subsp. aureus Mu50 (88 aa), FASTA scores: opt: 250, E(): 2e-11, (40.5% identity in 84 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15743.1" /db_xref="GI:2661636" /db_xref="InterPro:IPR009614" /db_xref="UniProtKB/Swiss-Prot:P64528" /translation="MRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIG KPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLKARYHY" gene 303681..304871 /locus_tag="Rv3359" CDS 303681..304871 /locus_tag="Rv3359" /EC_number="1.-.-.-" /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR METABOLISM." /note="Rv3359, (MTV004.16), len: 396 aa. Possible oxidoreductase (EC 1.-.-.-), similar to N-terminal part of various proteins (hypothetical unknowns or oxidoreductases) e.g. Q9ZB94 HYPOTHETICAL 69.3 KDA PROTEIN from Rhodococcus erythropolis (649 aa), FASTA scores: opt: 509, E(): 3e-24, (30.0% identity in 380 aa overlap); O29991|AF0248 NADH-DEPENDENT FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (378 aa), FASTA scores: opt: 478, E(): 1.6e-22, (32.45% identity in 379 aa overlap); Q9HUH9|PA4986 PROBABLE OXIDOREDUCTASE from Pseudomonas aeruginosa (648 aa), FASTA scores: opt: 412, E(): 3.3e-18, (30.45% identity in 384 aa overlap); Q9KCT8|BH1481 NADH OXIDASE from Bacillus halodurans (338 aa), FASTA scores: opt: 404, E(): 6.1e-18, (30.2% identity in 275 aa overlap); etc. Some weak similarity to Mycobacterium leprae MLCB1779_10." /codon_start=1 /transl_table=11 /product="POSSIBLE OXIDOREDUCTASE" /protein_id="CAA15744.1" /db_xref="GI:2661637" /db_xref="GOA:O50388" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR003009" /db_xref="UniProtKB/TrEMBL:O50388" /translation="MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVTDD LIEYHRLPAAGGVAMTTVAYCAVSPGGRTGGNQIWMRPHAVPGLRRLTEAIHAEGAAI SAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKATREDIDDVLAAHAHAARLAV DAGFDAVEIHLGHNYLASAFLSPLLNRRDDEFGGSLQNRAKVARGLVMAVRRAVRQQV AVTAKLNMTDGIRGGITVDEALTTARWLQDDGGLDAIELTAGSSLVNPMYLFRGDAPV KEFAAAFKPPLRWGIRMTGHRFFREYPYRDAYLLREARLFRAELTIPLILLGGITNRT TMDLAMAEGFEFVAMARALLAEPDLVNRIAAEGSQVRSACTHCNQCMATIYRRTHCVV TGAP" gene 304988..305356 /locus_tag="Rv3360" CDS 304988..305356 /locus_tag="Rv3360" /function="UNKNOWN" /note="Rv3360, (MTV004.17), len: 122 aa. Hypothetical protein, highly similar to the N-terminus of O65934|Rv1747|MTCY28.10|MTCY04C12.31 probable ABC-transporter ATP-binding protein from Mycobacterium tuberculosis (865 aa), FASTA scores: opt: 480, E(): 4.7e-25, (61.0% identity in 118 aa overlap); and some similarity with the N-terminus of P96214|Rv3863|MTCY01A6.05c HYPOTHETICAL 41.1 KDA PROTEIN from Mycobacterium tuberculosis (392 aa), FASTA scores: opt: 138, E(): 0.033, (31.95% identity in 97 aa overlap). Some weak similarity with the N-terminus of other hypothetical proteins e.g. P73823|CYAA|SLR1991 ADENYLATE CYCLASE from Synechocystis sp. strain PCC 6803 (337 aa), FASTA scores: opt: 127, E(): 0.16, (28.55% identity in 112 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15745.1" /db_xref="GI:2661638" /db_xref="InterPro:IPR000253" /db_xref="UniProtKB/TrEMBL:O50389" /translation="MSRPHPPVLTVRSDRSQQCFAAGRDVVVGSDLRADMRVAHPLIA RAHLLLRFDRGNWIAIDNDSQSGMFVDGQRVSEVDIYDGLTINIGKPTGPWITFEVGH HQGIIGRLSRTPSSRPGSPI" gene complement(305353..305904) /locus_tag="Rv3361c" CDS complement(305353..305904) /locus_tag="Rv3361c" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3361c, (MTV004.18c), len: 183 aa. Conserved hypothetical protein, with some similarity to various proteins e.g. P74221|YB52_SYNY3|SLR1152 HYPOTHETICAL 36.2 KDA PROTEIN SLR (CONTAINS 5 PENTAPEPTIDE REPEAT DOMAINS) from Synechocystis sp. strain PCC 6803 (331 aa), FASTA scores: opt: 252, E(): 3.9e-10, (30.55% identity in 167 aa overlap); Q9SE95 FH PROTEIN INTERACTING PROTEIN FIP2 from Arabidopsis thaliana (Mouse-ear cress) (298 aa), FASTA scores: opt: 207, E(): 4.4e-07, (30.35% identity in 168 aa overlap); Q9A735|CC1891 PENTAPEPTIDE REPEAT FAMILY PROTEIN from Caulobacter crescentus (250 aa), FASTA scores: opt: 181, E(): 2.3e-05, (24.05% identity in 187 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15746.1" /db_xref="GI:2661639" /db_xref="InterPro:IPR001646" /db_xref="UniProtKB/TrEMBL:O50390" /translation="MQQWVDCEFTGRDFRDEDLSRLHTERAMFSECDFSGVNLAESQH RGSAFRNCTFERTTLWHSTFAQCSMLGSVFVACRLRPLTLDDVDFTLAVLGGNDLRGL NLTGCRLRETSLVDTDLRKCVLRGADLSGARTTGARLDDADLRGATVDPVLWRTASLV GARVDVDQAVAFAAAHGLCLAGG" gene complement(305911..306492) /locus_tag="Rv3362c" CDS complement(305911..306492) /locus_tag="Rv3362c" /function="UNKNOWN" /note="Rv3362c, (MTV004.19c), len: 193 aa. Probable ATP/GTP-binding protein, similar to others from Streptomyces coelicolor e.g. O86519|SC1C2.18c (174 aa), FASTA scores: opt: 731, E(): 9.8e-41, (66.85% identity in 169 aa overlap); Q9XAE1|SC6G9.41c (191 aa), FASTA scores: opt: 730, E(): 1.2e-40, (63.55% identity in 173 aa overlap); Q9L235|SC1A2.06 (184 aa), FASTA scores: opt: 650, E(): 1.9e-35, (55.95% identity in 177 aa overlap); Q9RJ74|SCI41.10c (176 aa), FASTA scores: opt: 618, E(): 2.3e-33, (55.9% identity in 161 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)." /codon_start=1 /transl_table=11 /product="PROBABLE ATP/GTP-BINDING PROTEIN" /protein_id="CAA15747.1" /db_xref="GI:2661640" /db_xref="GOA:O50391" /db_xref="InterPro:IPR004130" /db_xref="UniProtKB/TrEMBL:O50391" /translation="MALKHSEASGTASTKIVIAGGFGSGKTTFVGAVSEIMPLRTEAM VTDASAGVDMLEATPDKRSTTVAMDFGRITLGEDLVLYLFGTPGQRRFWFMWDDLVRG AIGAIVLVDCRRLQDSFAAVDFFEHRNLPFLIAINEFDSAPRYPVSAVRDALTLPAHI PVINVDARNRRSATDALIAVSEYALATLSPAGG" misc_feature complement(306412..306435) /locus_tag="Rv3362c" /note="PS00017 ATP/GTP-binding site motif A (P-loop)" gene complement(306473..306841) /locus_tag="Rv3363c" CDS complement(306473..306841) /locus_tag="Rv3363c" /function="UNKNOWN" /note="Rv3363c, (MTV004.20c), len: 122 aa. Conserved hypothetical protein, similar to others from Streptomyces coelicolor e.g. O86523|SC1C2.23c (132 aa), FASTA scores: opt: 236, E(): 9e-09, (38.5% identity in 122 aa overlap); O86520|SC1C2.19c (190 aa), FASTA scores: opt: 231, E(): 2.7e-08, (41.0% identity in 122 aa overlap); Q9X834|SC9B1.14c (119 aa), FASTA scores: opt: 188, E(): 1.1e-05, (37.5% identity in 120 aa overlap); Q9ADJ4|SCBAC14E8.05 (113 aa), FASTA scores: opt: 167, E(): 0.00025, (33.05% identity in 109 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15748.1" /db_xref="GI:2661641" /db_xref="InterPro:IPR007995" /db_xref="UniProtKB/TrEMBL:O50392" /translation="MFNPAGDRPKAGLVRPYTLTAGRTGTDVDLPLQAPVQTLPAGPA GRWPAYDMRRRILQLCIGSPSVAEISARLDLPVGVARVLVGDLVTSGYLRVHATLTDR STRDERHELIGRTLRGLKAL" gene complement(306819..307211) /locus_tag="Rv3364c" CDS complement(306819..307211) /locus_tag="Rv3364c" /function="UNKNOWN" /note="Rv3364c, (MTV004.21c), len: 130 aa. Conserved hypothetical protein, highly similar to others from Streptomyces coelicolor e.g. O86524|SC1C2.24c (137 aa), FASTA scores: opt: 466, E(): 1.3e-22, (58.6% identity in 116 aa overlap); O86521|SC1C2.20c (140 aa), FASTA scores: opt: 445, E(): 2.7e-21, (56.9% identity in 116 aa overlap); Q9KZI6|SCG8A.13c (145 aa), FASTA scores: opt: 341, E(): 9.5e-15, (51.3% identity in 113 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15749.1" /db_xref="GI:2661642" /db_xref="InterPro:IPR004942" /db_xref="UniProtKB/TrEMBL:O50393" /translation="MKARLPDSPLDWLVSKFAREVPGVAHALLVSVDGLPVAASEHLP RERADQLAAVTSGLASLAGGAAQLFDGGQVLQSVVEMQNGYLLLMQVGDGSALAALAA TGCDIGQIGYEMAILVERVGGVVQSCRR" gene complement(307208..309838) /locus_tag="Rv3365c" CDS complement(307208..309838) /locus_tag="Rv3365c" /function="UNKNOWN" /note="Rv3365c, (MTV004.22c), len: 876 aa. Conserved hypothetical protein, similar to various proteins from Streptomyces coelicolor e.g. O86525|SC1C2.25c HYPOTHETICAL 139.7 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1329 aa), FASTA scores: opt: 879, E(): 5.4e-32, (29.9% identity in 924 aa overlap) (similarity in N-terminal part for this one); O86522|SC1C2.21c HYPOTHETICAL 119.9 KDA PROTEIN (SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION HISTIDINE KINASES) (1111 aa), FASTA scores: opt: 855, E(): 5.6e-31, (28.9% identity in 892 aa overlap) (similarity in N-terminal part for this one); Q9KZI5|SCG8A.14c PUTATIVE MEMBRANE PROTEIN (862 aa), FASTA scores: opt: 791, E(): 3.3e-28, (30.8% identity in 828 aa overlap); Q9KZN0|SC1A8A.22c (943 aa), FASTA scores: opt: 660, E(): 2.5e-22, (27.65% identity in 893 aa overlap); etc. Similar in part to two consecutive Mycobacterium leprae hypothetical ORFs, probably representing a pseudogene: O07701|MLCL383.27 (118 aa), FASTA scores: opt: 430, E(): 1e-12, (58.25% identity in 115 aa overlap); and O07700|MLCL383.26 (111 aa), FASTA scores: opt: 271, E(): 1.3e-05, (50.4% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15750.1" /db_xref="GI:2661643" /db_xref="GOA:Q93IG6" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR006025" /db_xref="UniProtKB/TrEMBL:Q93IG6" /translation="MTMFARPTIPVAAAASDISAPAQPARGKPQQRPPSWSPRNWPVR WKVFTIALLPLVVAMVLAGLRVEAAMASTSGLRLVAARAEMIPAITKYMSALDVAVLA SSTGHDVEGAQKNFTARKYELQTRLADTDVIADVRSGVNTLLNGGQALLDKVLADSIG LRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQEILVTRGA DLAEPQLRSAMVTLAGTEPSTLFGMSAALGAGSPDTKNLQQQMVTRMAIMSDPAVALV NNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIV VVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVA HAVDELHTRALLLAGEETRLRLLVNEMFETMSRRSRSLVDQQLSVIDQLERNEEDPAR LDSLFRLDHLAARLRRNSANLLVLAGAQITRDHREPVPLSTVISAAVSEVEDYRRVDI ARVPDCAVVGAAAGGVIHLLAELIDNALRYSSPTTPVRVAAAIGSEGSVLLRISDSGL GMTDADRRMANMRLRAGGEVTPDSARHMGLFVVGRLAGRHGIRVGLRGPVTGEQGTGT TAEVYLPLAVLEGTAPAQPPKPRVFAIKPPCPEPAAADPTDVPAAIGPLPPVTLLPRR TPGSSGIADVPAQPMQQRRRELKTPWWEDRFQQEPKQPPAPEPRPAPPPAKPAPPAGP VDDDVIYRRMLSEMVGDPHELAHSPDLDWKSVWDHGWSAAAEAADKPVQSRTDYGLPV REPGARLVPGAAVPEGPDREHPGAALASNGGLHPGRAPRHAAAVRDPDAVRASISSHF GGVRTGRSHARESSQGPNQQ" misc_feature complement(307544..307573) /locus_tag="Rv3365c" /note="PS00142 Neutral zinc metallopeptidases, zinc-binding region signature" gene 310074..310538 /gene="spoU" /locus_tag="Rv3366" CDS 310074..310538 /gene="spoU" /locus_tag="Rv3366" /EC_number="2.1.1.-" /function="CAUSES METHYLATION." /note="Rv3366, (MTV004.23), len: 154 aa. Probable spoU, tRNA/rRNA methylase (EC 2.1.1.-), equivalent to Q9CCU7|ML0419 PUTATIVE tRNA/rRNA METHYLTRANSFERASE from Mycobacterium leprae (158 aa), FASTA scores: opt: 861, E(): 1.2e-50, (83.75% identity in 154 aa overlap); and O07698|MLCL383.24c rRNA METHYLASE from Mycobacterium leprae (169 aa), FASTA scores: opt: 861, E(): 1.3e-50, (83.75% identity in 154 aa overlap). Also highly similar to many members of the spoU family of rRNA methylases e.g. Q9K199|NMB0268 RNA METHYLTRANSFERASE (TRMH FAMILY) from Neisseria meningitidis (serogroup B) (154 aa), FASTA scores: opt: 534, E(): 7.6e-29, (50.0% identity in 154 aa overlap); and Q9JSM8|NMA2218 from Neisseria meningitidis (serogroup A) (154 aa), FASTA scores: opt: 526, E(): 2.6e-28, (49.35% identity in 154 aa overlap); Q9HU57|PA5127 from Pseudomonas aeruginosa (153 aa), FASTA scores: opt: 531, E(): 1.2e-28, (52.95% identity in 151 aa overlap); P33899|YIBK_ECOLI|B3606 from Escherichia coli strain K12 (157 aa), FASTA scores: opt: 511, E(): 2.6e-27, (49.35% identity in 154 aa overlap); etc. BELONGS TO THE RNA METHYLTRANSFERASE TRMH FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE tRNA/rRNA METHYLASE SPOU (tRNA/rRNA METHYLTRANSFERASE)" /protein_id="CAA15751.1" /db_xref="GI:2661644" /db_xref="GOA:O50394" /db_xref="InterPro:IPR001537" /db_xref="UniProtKB/TrEMBL:O50394" /translation="MFRLLFVSPRIAPNTGNAIRTCAATGCELHLVEPLGFDLSEPKL RRAGLDYHDLASVTVHASLAHAWEALSPARVFAFTAQATTLFTNVGYRAGDVLMFGPE PTGLDEATLADTHITGQVRIPMLAGRRSLNLSNAAAVAVYEAWRQHGFAGAV" gene 310905..312671 /gene="PE_PGRS51" /locus_tag="Rv3367" CDS 310905..312671 /gene="PE_PGRS51" /locus_tag="Rv3367" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3367, (MTV004.25), len: 588 aa. Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O50415|Rv3388|MTV004.46 (731 aa), FASTA scores: opt: 1999, E(): 7.2e-72, (55.0% identity in 620 aa overlap); and MTV004_44, MTV043_65, MTV006_15, MTCY63_2, MTCY21B4_13, MTV023_21, MTV008_43, MTCY24A1_4, MTV023_15; etc. Equivalent to AAK47814 from Mycobacterium tuberculosis strain CDC1551 (628 aa) but shorter 37 aa." /codon_start=1 /transl_table=11 /product="PE-PGRS FAMILY PROTEIN" /protein_id="CAE55590.1" /db_xref="GI:38490363" /db_xref="InterPro:IPR000084" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR002952" /db_xref="UniProtKB/TrEMBL:Q6MWX7" /translation="MSFVVAVPEALAAAASDVANIGSALSAANAAAAAGTTGLLAAGA DEVSAALASLFSGHAVSYQQVAAQATALHDQFVQALTGAGGSYALTEAANVQQNLLNA INAPTQALLGRPLIGDGAVGTASSPDGQDGGLLFGNGGAGYNSAATPGMAGGNGGNAG LIGNGGTGGSGGAGAAGGAGGSGGWLYGNGGNGGIGGNAIVAGGAGGNGGAGGAAGLW GSGGSGGQGGNGLTGNDGVNPAPVTNPALNGAAGDSNIEPQTSVLIGTQGGDGTPGGA GVNGGNGGAGGDANGNPANTSIANAGAGGNGAAGGDGGANGGAGGAGGQAASAGSSVG GDGGNGGAGGTGTNGHAGGAGGAGGAGGRGGWLVGNGGNGGNGAAGGNGAIGGTGGAG GVPANQGGNSALGTQPVGGDGGDGGNGGTGGTGGRGGDGGSGGAGGASGWLMGNGGNG GNGGTGGSGGVGGNGGIGGDGAGGGNATSTSSIPFDAHGGNGGAGGDAGHGGTGGDGG DGGHAGTGGRGGLLAGQHANSGNGGGGGTGGAGGTHGTPGSGNAGGTGTGNADSTNGG PGSDGLGGDAFNGSRGTDGNPG" gene complement(312672..313316) /locus_tag="Rv3368c" CDS complement(312672..313316) /locus_tag="Rv3368c" /EC_number="1.-.-.-" /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR METABOLISM" /note="Rv3368c, (MTV004.26c), len: 214 aa. Possible oxidoreductase (EC 1.-.-.-), equivalent to O07697|MLCL383.23|ML0418 HYPOTHETICAL 23.6 KDA PROTEIN (PUTATIVE OXIDOREDUCTASE) from Mycobacterium leprae (210 aa), FASTA scores: opt: 1215, E(): 1.5e-74, (81.4% identity in 210 aa overlap). Also similar to O30106|AF0131 PUTATIVE NAD(P)H-FLAVIN OXIDOREDUCTASE from Archaeoglobus fulgidus (194 aa), FASTA scores: opt: 139, E(): 0.028, (29.0% identity in 207 aa overlap); Q60049|NOX_THETH NADH DEHYDROGENASE from Thermus aquaticus (subsp. thermophilus) (205 aa), FASTA scores: opt: 169, E(): 0.00028, (28.3% identity in 212 aa overlap); and shows some similarity to other hypothetical proteins (unknowns or oxidoreductases)." /codon_start=1 /transl_table=11 /product="POSSIBLE OXIDOREDUCTASE" /protein_id="CAA15753.1" /db_xref="GI:2661647" /db_xref="GOA:O50397" /db_xref="InterPro:IPR000415" /db_xref="UniProtKB/TrEMBL:O50397" /translation="MTLNLSVDEVLTTTRSVRKRLDFDKPVPRDVLMECLELALQAPT GSNSQGWQWVFVEDAAKKKAIADVYLANARGYLSGPAPEYPDGDTRGERMGRVRDSAT YLAEHMHRAPVLLIPCLKGREDESAVGGVSFWASLFPAVWSFCLALRSRGLGSCWTTL HLLDNGEHKVADVLGIPYDEYSQGGLLPIAYTQGIDFRPAKRLPAESVTHWNGW" gene 313315..313749 /locus_tag="Rv3369" CDS 313315..313749 /locus_tag="Rv3369" /function="UNKNOWN" /note="Rv3369, (MTV004.27), len: 144 aa. Conserved hypothetical protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c HYPOTHETICAL 14.7 KDA PROTEIN from Mycobacterium leprae (131 aa), FASTA scores: opt: 174, E(): 6e-05, (67.55% identity in 37 aa overlap). Also some slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces coelicolor (153 aa), FASTA scores: opt: 125, E(): 0.13, (31.05% identity in 116 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15754.1" /db_xref="GI:2661648" /db_xref="InterPro:IPR011576" /db_xref="UniProtKB/TrEMBL:O50398" /translation="MWAGYRWAMSVELTQEVSARLTSDLYGWLTTVARSGQPVPRLVW FYFDGTDLTVYSMPQAAKVAHITAHPQVSLNLDSDGNGAGIIVVGGTAAVVATDVDCR DDAPYWAKYREDAAKFGLTEAIAAYSTRLKITPTRVWTTPTG" gene complement(313838..317077) /gene="dnaE2" /locus_tag="Rv3370c" CDS complement(313838..317077) /gene="dnaE2" /locus_tag="Rv3370c" /EC_number="2.7.7.7" /function="DNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THE ALPHA CHAIN IS THE DNA POLYMERASE. THOUGHT TO BE REGULATED BY Rv2720|LEXA [CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + DNA(N)]." /experiment="experimental evidence, no additional details recorded" /note="Rv3370c, (MTV004.28c), len: 1079 aa. Probable dnaE2, DNA polymerase III, alpha chain (EC 2.7.7.7) (see citations below), similar to many e.g. BAB51086|MLR4428 from Rhizobium loti (Mesorhizobium loti) (1118 aa), FASTA scores: opt: 1103, E(): 8.9e-59, (37.65% identity in 1075 aa overlap); Q9S291|SCI11.28c from Streptomyces coelicolor (1185 aa), FASTA scores: opt: 937, E(): 1e-48, (33.4% identity in 1090 aa overlap); O67125|DP3A_AQUAE|DNAE|AQ_1008 from Aquifex aeolicus (1161 aa), FASTA scores: opt: 895, E(): 3.4e-46, (29.9% identity in 1071 aa overlap); O51526|DP3A_BORBU from Borrelia burgdorferi (Lyme disease spirochete) (1147 aa), FASTA scores: opt: 835, E(): 1.4e-42, (30.05% identity in 888 aa overlap); etc. Equivalent to AAK47817 from Mycobacterium tuberculosis strain CDC1551 (1098 aa) but shorter 19 aa. Also similar to Mycobacterium tuberculosis DP3A_MYCTU|MTCY48.18c|dnaE1 (29.6% identity in 1110 aa overlap). BELONGS TO DNA POLYMERASE TYPE-C FAMILY, DNAE SUBFAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE2 (DNA NUCLEOTIDYLTRANSFERASE)" /protein_id="CAA15755.1" /db_xref="GI:2661649" /db_xref="GOA:O50399" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="UniProtKB/TrEMBL:O50399" /translation="MERVLNGKPRHAGVPAFDADGDVPRSRKRGAYQPPGRERVGSSV AYAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDV RTVFGAELSLGATARTERPDPPGPHLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRY DFDALTEAAGGHWHILTGCRKGHVRQALSQGGPAAAQRALADLVDRFTPSRVSIELTH HGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAG WLAPLGGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHT EDSWLRSLVMAGARERYGPPKSAPRAYSQIEHELKVIAQLRFPGYFLVVHDITRFCRD NDILCQGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDIDIDIESDQRE KVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQVSHWTGQA DDVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWARMANRSVLQWD KDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARAD SVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVHPYIRRRNGVDPVI YEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGSKRSTERMRRLR GRFYDGMRALHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAA FCAALLRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHATCENAGTEVRLGLGAV RYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSVPQVEALATAGALGCFGMSRREAL WAAGAAATGRPDRLPGVGSSSHIPALPGMSELELAAADVWATGVSPDSYPTQFLRADL DAMGVLPAERLGSVSDGDRVLIAGAVTHRQRPATAQGVTFINLEDETGMVNVLCTPGV WARHRKLAHTAPALLIRGQVQNASGAITVVAERMGRLTLAVGARSRDFR" gene 317269..318609 /locus_tag="Rv3371" CDS 317269..318609 /locus_tag="Rv3371" /function="UNKNOWN" /note="Rv3371, (MTV004.29), len: 446 aa. Hypothetical protein, similar to many Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. O07035|YV30_MYCTU|Rv3130c|MTCY03A2.28|MTCY164.41c (463 aa), FASTA scores: opt: 556, E(): 7.7e-28, (44.95% identity in 447 aa overlap); MTY20B11_9, MTCY28_26, MTV013_8, MTCY21B4_43, MTCY493_29; etc. Also similar to O07692|MLCL383_9|MLCL383.18c HYPOTHETICAL 14.1 KDA PROTEIN from Mycobacterium leprae (129 aa), FASTA scores: opt: 293, E(): 1.3e-11, (47.85% identity in 117 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15756.1" /db_xref="GI:2661650" /db_xref="GOA:O50400" /db_xref="InterPro:IPR004255" /db_xref="UniProtKB/Swiss-Prot:O50400" /translation="MAQLTALDAGFLKSRDPERHPGLAIGAVAVVNGAAPSYDQLKTV LTERIKSIPRCTQVLATEWIDYPGFDLTQHVRRVALPRPGDEAELFRAIALALERPLD PDRPLWECWIIEGLNGNRWAILIKIHHCMAGAMSAAHLLARLCDDADGSAFANNVDIK QIPPYGDARSWAETLWRMSVSIAGAVCTAAARAVSWPAVTSPAGPVTTRRRYQAVRVP RDAVDAVCHKFGVTANDVALAAITEGFRTVLLHRGQQPRADSLRTLEKTDGSSAMLPY LPVEYDDPVRRLRTVHNRSQQSGRRQPDSLSDYTPLMLCAKMIHALARLPQQGIVTLA TSAPRPRHQLRLMGQKMDQVLPIPPTALQLSTGIAVLSYGDELVFGITADYDAASEMQ QLVNGIELGVARLVALSDDSVLLFTKDRRKRSSRALPSAARRGRPSVPTARARH" gene 318651..319826 /gene="otsB2" /locus_tag="Rv3372" CDS 318651..319826 /gene="otsB2" /locus_tag="Rv3372" /EC_number="3.1.3.12" /function="INVOLVED IN OSMOREGULATORY TREHALOSE BIOSYNTHESIS. Mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [CATALYTIC ACTIVITY: TREHALOSE 6-PHOSPHATE + H(2)O = TREHALOSE + ORTHOPHOSPHATE]." /note="Rv3372, (MTV004.30),len: 391 aa. Possible otsB2, trehalose-6-phosphate phosphatase (EC 3.1.3.12), equivalent to Q49734|OTSB2|OTSP|B1620_F1_1|MLCL383.17c PUTATIVE TREHALOSE-PHOSPHATASE from Mycobacterium leprae (429 aa), FASTA scores: opt: 1675, E(): 2.4e-91, (67.05% identity in 425 aa overlap). Also weakly similar to several trehalose phosphatases e.g. Q9C8B3|F10O5.8 from Arabidopsis thaliana (Mouse-ear cress) (366 aa), FASTA scores: opt: 432, E(): 3.1e-18, (36.65% identity in 281 aa overlap); O27788|MTH1760 from Methanobacterium thermoautotrophicum (264 aa), FASTA scores: opt: 347, E(): 2.5e-13, (30.75% identity in 221 aa overlap); Q9FWQ2 from Oryza sativa (Rice) (382 aa), FASTA scores: opt: 338, E(): 1.1e-12, (32.5% identity in 320 aa overlap); etc. Also similar to part of Mycobacterium tuberculosis Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa), FASTA scores: opt: 1192, E(): 1.6e-62, (56.65% identity in 339 aa overlap)." /codon_start=1 /transl_table=11 /product="POSSIBLE TREHALOSE 6-PHOSPHATE PHOSPHATASE OTSB2 (TREHALOSE-PHOSPHATASE) (TPP)" /protein_id="CAA15757.1" /db_xref="GI:2661651" /db_xref="GOA:O50401" /db_xref="InterPro:IPR003337" /db_xref="InterPro:IPR006379" /db_xref="UniProtKB/TrEMBL:O50401" /translation="MRKLGPVTIDPRRHDAVLFDTTLDATQELVRQLQEVGVGTGVFG SGLDVPIVAAGRLAVRPGRCVVVSAHSAGVTAARESGFALIIGVDRTGCRDALRRDGA DTVVTDLSEVSVRTGDRRMSQLPDALQALGLADGLVARQPAVFFDFDGTLSDIVEDPD AAWLAPGALEALQKLAARCPIAVLSGRDLADVTQRVGLPGIWYAGSHGFELTAPDGTH HQNDAAAAAIPVLKQAAAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDRVGEVAAAV RTAEQRHALRVTTGREVIELRPDVDWDKGKTLLWVLDHLPHSGSAPLVPIYLGDDITD EDAFDVVGPHGVPIVVRHTDDGDRATAALFALDSPARVAEFTDRLARQLREAPLRAT" gene 320063..320704 /gene="echA18" /locus_tag="Rv3373" CDS 320063..320704 /gene="echA18" /locus_tag="Rv3373" /EC_number="4.2.1.17" /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." /note="Rv3373, (MTV004.31), len: 213 aa. Probable echA18, enoyl-CoA hydratase (EC 4.2.1.17), similar to others e.g. P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 423, E(): 3.4e-20, (37.95% identity in 174 aa overlap); Q9X7Q4|SC5F2A.31c from Streptomyces coelicolor (257 aa), FASTA scores: opt: 399, E(): 1.2e-18, (45.05% identity in 171 aa overlap); BAB52005|MLL5584 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 385, E(): 9.6e-18, (41.95% identity in 174 aa overlap); etc. Also some similarity to 3-HYDROXYBUTYRYL-CoA DEHYDRATASES (EC 4.2.1.55) e.g. P52046|CRT_CLOAB from Clostridium acetobutylicum (261 aa), FASTA scores: opt: 414, E(): 1.3e-19, (38.3% identity in 175 aa overlap). And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-CoA HYDRATASE (257 aa), FASTA scores: opt: 365, E(): 1.9e-16, (39.1% identity in 174 aa overlap). BELONGS TO THE ENOYL-CoA HYDRATASE/ISOMERASE FAMILY. Note that this homology extends across the stop codon and directly into the next ORF MTV004.29, suggesting a possible readthrough of the TGA stop codon." /codon_start=1 /transl_table=11 /product="PROBABLE ENOYL-CoA HYDRATASE ECHA18 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" /protein_id="CAA15758.1" /db_xref="GI:2661652" /db_xref="GOA:O50402" /db_xref="InterPro:IPR001753" /db_xref="UniProtKB/TrEMBL:O50402" /translation="MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQ RHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGAD IKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCI ATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARW" gene 320705..320953 /gene="echA18.1" /locus_tag="Rv3374" CDS 320705..320953 /gene="echA18.1" /locus_tag="Rv3374" /EC_number="4.2.1.17" /function="COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS [CATALYTIC ACTIVITY: (3S)-3-HYDROXYACYL-CoA = TRANS-2(OR 3)-ENOYL-CoA + H(2)O]." /standard_name="echA18'" /note="Rv3374, (MTV004.32), len: 82 aa. Probable echA18.1, enoyl-CoA hydratase C-terminus (EC 4.2.1.17), similar to the C-terminus of several enoyl-CoA hydratases e.g. Q9I5I4|PA0745 from Pseudomonas aeruginosa (272 aa), FASTA scores: opt: 123, E(): 0.13, (34.55% identity in 81 aa overlap); P97087|CRT from Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum) (259 aa), FASTA scores: opt: 115, E(): 0.45, (32.95% identity in 82 aa overlap); Q9I002|PA2841 from Pseudomonas aeruginosa (263 aa), FASTA scores: opt: 108, E(): 1.4, (30.95% identity in 84 aa overlap); etc. Also some similarity to C-terminus of O29956|AF0285 3-HYDROXYACYL-CoA DEHYDROGENASE from Archaeoglobus fulgidus (658 aa), FASTA scores: opt: 116, E(): 0.81, (34.15% identity in 82 aa overlap); and other enzymes. And similar to other hydratases from Mycobacterium tuberculosis e.g. O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c PROBABLE ENOYL-CoA HYDRATASE (257 aa), FASTA scores: opt: 111, E(): 0.83, (36.05% identity in 86 aa overlap). This homology extends across the upstream TGA stop codon into the upstream ORF MTV004.28, suggesting possible readthrough of the previous stop codon. Note that previously known as echA18'." /codon_start=1 /transl_table=11 /product="PROBABLE ENOYL-CoA HYDRATASE (FRAGMENT) ECHA18.1 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)" /protein_id="CAE55591.1" /db_xref="GI:38490364" /db_xref="GOA:Q6MWX6" /db_xref="UniProtKB/TrEMBL:Q6MWX6" /translation="MVQKVVAPQDLAAATAKLVGQVCRQSAVTMRAAKVVANMHGRAL TGADTDALIRFGVEAYEGADLREGVAAFSQGRPPKFDD" gene 320958..322385 /gene="amiD" /locus_tag="Rv3375" CDS 320958..322385 /gene="amiD" /locus_tag="Rv3375" /EC_number="3.5.1.4" /function="INVOLVED IN CELLULAR METABOLISM [CATALYTIC ACTIVITY: A MONOCARBOXYLIC ACID AMIDE + H(2)O = A MONOCARBOXYLATE + NH(3)]." /note="Rv3375, (MTV004.33), len: 475 aa. Probable amiD, amidase (EC 3.5.1.4), similar to various amidases e.g. Q53116|AMDA ENANTIOMERASE-SELECTIVE AMIDASE from Rhodococcus sp. (462 aa), FASTA scores: opt: 1036, E(): 1.6e-54, (38.6% identity in 464 aa overlap); Q9ZHK8|PZAA NICOTINAMIDASE/PYRAZINAMIDASE from Mycobacterium smegmatis (468 aa), FASTA scores: opt: 930, E(): 3.4e-48, (36.3% identity in 463 aa overlap); Q9A551|CC2613 PYRAZINAMIDASE/NICOTINAMIDASE from Caulobacter crescentus (464 aa), FASTA scores: opt: 841, E(): 7.1e-43, (39.45% identity in 469 aa overlap); O69768|AMID_PSEPU AMIDASE from Pseudomonas putida (466 aa), FASTA scores: opt: 800, E(): 2e-40, (33.6% identity in 467 aa overlap); O28325|YJ54_ARCFU|AF1954 PUTATIVE AMIDASE from Archaeoglobus fulgidu (453 aa), FASTA scores: opt: 669, E(): 1.3e-32, (30.4% identity in 467 aa overlap); etc. Also some similarity to AMIB2|Rv1263|MT1301|MTCY50.19c putative amidase from Mycobacterium tuberculosis (462 aa), (31.5% identity in 466 aa overlap). SEEMS BELONG TO THE AMIDASE FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE AMIDASE AMID (ACYLAMIDASE) (ACYLASE)" /protein_id="CAA15760.1" /db_xref="GI:2661654" /db_xref="GOA:P63496" /db_xref="InterPro:IPR000120" /db_xref="UniProtKB/Swiss-Prot:P63496" /translation="MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTL RRIERLDPQLKSYAFVMPETALAAARAADADIARGHYEGVLHGVPIGVKDLCYTVDAP TAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYHPSLPTPVNPWDPT AWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPTSMCGVTGIKPTWGRVSRHGVVEL AASYDHVGPITRSAHDAAVLLSVIAGSDIHDPSCSAEPVPDYAADLALTRIPRVGVDW SQTTSFDEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETAIAHADT YPARADEYGPIMRAMIDAGHRLAAVEYQTLTERRLEFTRSLRRVFHDVDILLMPSAGI ASPTLETMRGLGQDPELTARLAMPTAPFNVSGNPAICLPAGTTARGTPLGVQFIGREF DEHLLVRAGHAFQQVTGYHRRRPPV" gene 322493..323146 /locus_tag="Rv3376" CDS 322493..323146 /locus_tag="Rv3376" /function="UNKNOWN" /note="Rv3376, (MTV004.34), len: 217 aa. Hypothetical protein, similar to various bacterial proteins (notably hydrolases) e.g. Q9RUP0|DR1344 HYDROLASE from Deinococcus radiodurans (222 aa), FASTA scores: opt: 348, E(): 1.8e-15, (36.75% identity in 215 aa overlap); Q9RXA1|DR0414 HYDROLASE (CBBY/CBBZ/GPH/YIEH FAMILY) from Deinococcus radiodurans (155 aa), FASTA scores: opt: 233, E(): 3.5e-08, (36.4% identity in 151 aa overlap); Q9X0Q9|TM1177 CONSERVED HYPOTHETICAL PROTEIN from Thermotoga maritima (225 aa), FASTA scores: opt: 231, E(): 6.6e-08, (27.6% identity in 221 aa overlap); Q9ABI3|CC0244 HYDROLASE, HALOACID DEHALOGENASE-LIKE from Caulobacter crescentus (213 aa), FASTA scores: opt: 213, E(): 9.1e-07, (28.95% identity in 221 aa overlap); BAB38231|ECS4808 PUTATIVE PHOSPHATASE from Escherichia coli strain O157:H7 (206 aa), FASTA scores: opt: 210, E(): 1.4e-06, (26.95% identity in 193 aa overlap); etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15761.1" /db_xref="GI:2661655" /db_xref="GOA:O50405" /db_xref="InterPro:IPR005833" /db_xref="InterPro:IPR005834" /db_xref="InterPro:IPR006402" /db_xref="UniProtKB/TrEMBL:O50405" /translation="MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGW LNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEE ARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEA LGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP" gene complement(323185..324690) /locus_tag="Rv3377c" CDS complement(323185..324690) /locus_tag="Rv3377c" /function="UNKNOWN" /note="Rv3377c, (MTV004.35c), len: 501 aa. Possible cyclase; similarity with various proteins, notably cyclases involved in steroid biosynthesis in plants and bacteria e.g. BAB52679|MLR6369 from Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA scores: opt: 533, E(): 5.6e-27, (30.45% identity in 522 aa overlap); Q9ZTN8 COPALYL DIPHOSPHATE SYNTHASE 1 from Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA scores: opt: 484, E(): 1.2e-23, (28.35% identity in 388 aa overlap); Q38710|AC22 ABIETADIENE CYCLASE from Abies grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17, (25.55% identity in 462 aa overlap); Q41771|AN1 KAURENE SYNTHASE A from Zea mays (Maize) (823 aa), FASTA scores: opt: 377, E(): 1.1e-16, (29.75% identity in 390 aa overlap); Q9AJE4 DITERPENE CYCLASE-1 from Kitasatospora griseola (Streptomyces griseolosporeus) (499 aa), FASTA scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa overlap); Q9SAU6 E-ALPHA-BISABOLENE SYNTHASE (FRAGMENT) from Abies grandis (782 aa), FASTA scores: opt: 317, E(): 7.8e-13, (25.25% identity in 479 aa overlap); etc. Note that this and the upstream ORF MTV004.36c have a significantly lower GC bias than the rest of the genome." /codon_start=1 /transl_table=11 /product="POSSIBLE CYCLASE" /protein_id="CAA15762.1" /db_xref="GI:2661656" /db_xref="GOA:O50406" /db_xref="InterPro:IPR001330" /db_xref="UniProtKB/TrEMBL:O50406" /translation="METFRTLLAKAALGNGISSTAYDTAWVAKLGQLDDELSDLALNW LCERQLPDGSWGAEFPFCYEDRLLSTLAAMISLTSNKHRRRRAAQVEKGLLALKNLTS GAFEGPQLDIKDATVGFELIAPTLMAEAARLGLAICHEESILGELVGVREQKLRKLGG SKINKHITAAFSVELAGQDGVGMLDVDNLQETNGSVKYSPSASAYFALHVKPGDKRAL AYISSIIQAGDGGAPAFYQAEIFEIVWSLWNLSRTDIDLSDPEIVRTYLPYLDHVEQH WVRGRGVGWTGNSTLEDCDTTSVAYDVLSKFGRSPDIGAVLQFEDADWFRTYFHEVGP SISTNVHVLGALKQAGYDKCHPRVRKVLEFIRSSKEPGRFCWRDKWHRSAYYTTAHLI CAASNYDDALCSDAIGWILNTQRPDGSWGFFDGQATAEETAYCIQALAHWQRHSGTSL SAQISRAGGWLSQHCEPPYAPLWIAKTLYCSATVVKAAILSALRLVDESNQ" gene complement(324695..325585) /locus_tag="Rv3378c" CDS complement(324695..325585) /locus_tag="Rv3378c" /function="UNKNOWN" /note="Rv3378c, (MTV004.36c), len: 296 aa. Hypothetical unknown protein. Note that this ORF and the downstream ORF MTV004.35c have a significantly lower GC bias than the rest of the genome." /codon_start=1 /transl_table=11 /product="HYPOTHETICAL PROTEIN" /protein_id="CAA15763.1" /db_xref="GI:2661657" /db_xref="UniProtKB/TrEMBL:O50407" /translation="MNLVSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLEC NPQYDDYQQAALRQSIRILKMLFEHGIETVISPIFSDDLLDRGDRYIVQALEGMALLA NDEEILSFYKEHEVHVLFYGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTEHRLCFGV FGNDAAESVAQFSISWNETHGKPPTRREIIEGYYGEYVDKADMFIGFGRFSTFDFPLL SSGKTSLYFTVAPSYYMTETTLRRILYDHIYLRHFRPKPDYSAMSADQLNVLRNRYRA QPDRVFGVGCVHDGIWFAEG" gene complement(325594..327204) /gene="dxs2" /locus_tag="Rv3379c" CDS complement(325594..327204) /gene="dxs2" /locus_tag="Rv3379c" /EC_number="2.2.-.-" /function="CATALYZES THE ACYLOIN CONDENSATION REACTION BETWEEN C ATOMS 2 AND 3 OF PYRUVATE AND GLYCERALDEHYDE 3-PHOSPHATE TO YIELD 1-DEOXY-D-XYLULOSE-5-PHOSPHATE (DXP). POSSIBLY INVOLVED IN DEOXYXYLULOSE-5-PHOSPHATE PATHWAY (DXP) OF ISOPRENOID BIOSYNTHESIS (AT THE FIRST STEP), AND BIOSYNTHETIC PATHWAY TO THIAMINE ANDPYRIDOXOL (AT THE FIRST STEP)." /note="Rv3379c, (MTV004.37c), len: 536 aa. Probable dxs2, 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.-.-), similar to many e.g. Q9F1V2|DXS from Kitasatospora griseola (Streptomyces griseolosporeus) (649 aa), FASTA scores: opt: 1274, E(): 5.4e-71, (50.9% identity in 570 aa overlap); Q9X7W3|DXS_STRCO|SC6A5.17 from Streptomyces coelicolor (656 aa), FASTA scores: opt: 1248, E(): 2.2e-69, (50.55% identity in 568 aa overlap); Q9RBN6|DXS_STRC1 from Streptomyces sp. strain CL190 (631 aa), FASTA scores: opt: 1237, E(): 1e-68, (49.1% identity in 570 aa overlap); Q50000|DXS_MYCLE|TKTB|ML1038 from Mycobacterium leprae (643 aa), FASTA scores: opt: 1215, E(): 2.4e-67, (46.75% identity in 571 aa overlap); Q9R6S7|DXS_SYNLE from Synechococcus leopoliensis (636 aa), FASTA scores: opt: 849, E(): 8.9e-45, (38.55% identity in 550 aa overlap); etc. Also similar to O07184|DXS_MYCTU|Rv2682c|MT2756|MTCY05A6.03c from Mycobacterium tuberculosis (638 aa), FASTA scores: opt: 1226, E(): 4.9e-68, (48.9% identity in 558 aa overlap). BELONGS TO THE TRANSKETOLASE FAMILY, DXS SUBFAMILY. COFACTOR: THIAMINE PYROPHOSPHATE (BY SIMILARITY). Note that the N-terminus of this putative protein appears to have been interrupted by the adjacent IS6110 element." /codon_start=1 /transl_table=11 /product="PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS2 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS)" /protein_id="CAA15764.1" /db_xref="GI:2661658" /db_xref="GOA:O50408" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005476" /db_xref="UniProtKB/TrEMBL:O50408" /translation="MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWV ENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVI VVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVL RKAAAAARPVVVHAVTSKGRGYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVF EDEIARIADDRSDVVGLTAAMRLPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAA GTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLA CVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTP PPHWRPDVLLVAVGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRI TVCVEDAIADVGIGAHLSHHIGRTHPRTRTYTLGLPPAYIPHASRDHILSSHGLTGPA IRIRCKSLLNALHEVPGPEDHPDSGDSY" repeat_region 327395..328749 /note="IS6110-15, len: 1355 bp. Insertion sequence IS6110." /insertion_seq="IS6110-15" repeat_unit 327395..327422 /note="28 bp inverted repeat at the left end of IS6110, TGAACCGCCCCGGTGAGTCCGGAGACTC" gene complement(327437..328321) /locus_tag="Rv3380c" CDS complement(327437..328321) /locus_tag="Rv3380c" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS6110." /note="Rv3380c, (MTV004.38c), len: 294 aa. Probable transposase (IS6110 ORF II), identical to many. May be expressed by frameshifting from the upstream ORF MTV004.39c." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA15765.1" /db_xref="GI:2661659" /db_xref="GOA:P19774" /db_xref="UniProtKB/Swiss-Prot:P19774" /translation="MRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKE HISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIAD PATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVAST MATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGA VGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVP PVELEAAYYAQRQRPAAG" gene complement(328372..328698) /locus_tag="Rv3381c" CDS complement(328372..328698) /locus_tag="Rv3381c" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS6110." /note="Rv3381c, (MTV004.39c), len: 108 aa. Probable transposase (IS6110 ORF I), identical to many." /codon_start=1 /transl_table=11 /product="PROBABLE TRANSPOSASE" /protein_id="CAA15766.1" /db_xref="GI:2661660" /db_xref="GOA:Q50686" /db_xref="InterPro:IPR002514" /db_xref="InterPro:IPR009057" /db_xref="UniProtKB/Swiss-Prot:Q50686" /translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE LDRPAR" repeat_unit complement(328722..328749) /note="28 bp inverted repeat at the right end of IS6110, TGAACCGCCCCGGCATGTCCGGAGACTC" gene complement(328785..329774) /gene="lytB1" /locus_tag="Rv3382c" CDS complement(328785..329774) /gene="lytB1" /locus_tag="Rv3382c" /function="NOT KNOW. POSSIBLY INVOLVED IN DRUG/ANTIBIOTIC TOLERANCE. IN OTHER ORGANISMS, LYTB PRODUCT IS INVOLVED IN PENICILLIN TOLERANCE AND CONTROL OF THE STRINGENT RESPONSE." /note="Rv3382c, (MTV004.40c), len: 329 aa. Probable lytB1, lytB-related protein, highly similar to many e.g. Q9HVM7|LYTB_PSEAE|PA4557 from Pseudomonas aeruginosa (314 aa), FASTA scores: opt: 1048, E(): 2e-55, (53.2% identity in 314 aa overlap); Q9JR39|LYTB|NMA0624|NMB1831 from Neisseria meningitidis (serogroup A and B) (322 aa), FASTA scores: opt: 1041, E(): 5.4e-55, (52.25% identity in 312 aa overlap); P22565|LYTB_ECOLI|B0029 from Escherichia coli strain K12 (316 aa), FASTA scores: opt: 1013, E(): 2.5e-53, (51.45% identity in 311 aa overlap) (for more information about lytB protein, see citation below); Q9X781|LYTB_MYCLE|LYTB2|ML1938|MLCB1222.06c from Mycobacterium leprae (332 aa), FASTA scores: opt: 979, E(): 2.8e-51, (51.3% identity in 312 aa overlap); etc. Also similar to Q9PAS9|XF2416 DRUG TOLERANCE PROTEIN from Xylella fastidiosa (316 aa), FASTA scores: opt: 1043, E(): 4.1e-55, (53.65% identity in 315 aa overlap). And similar to O53458|Rv1110|LYTB2|MTV017.63 from Mycobacterium tuberculosis (335 aa), FASTA scores: opt: 975, E(): 4.9e-51, (51.3% identity in 312 aa overlap). BELONGS TO THE LYTB FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE LYTB-RELATED PROTEIN LYTB1" /protein_id="CAE55592.1" /db_xref="GI:38490365" /db_xref="GOA:P0A5I2" /db_xref="InterPro:IPR003451" /db_xref="UniProtKB/Swiss-Prot:P0A5I2" /translation="MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLD VAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVR AGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTL LVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDALRARFPTLGQPPSEDICYAT TNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSS VSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ" gene complement(329774..330826) /gene="idsB" /locus_tag="Rv3383c" CDS complement(329774..330826) /gene="idsB" /locus_tag="Rv3383c" /EC_number="2.5.1.-" /function="INVOLVED IN BIOSYNTHESIS OF MEMBRANE ETHER-LINKED LIPIDS. CATALYZES THE TRANS-ADDITION OF THE THREE MOLECULES OF IPP ONTO DMAPP TO FORM GERANYLGERANYL PYROPHOSPHATE WHICH IS A PRECURSOR OF THE ETHER-LINKED LIPIDS. catalyze the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths." /note="Rv3383c, (MTV004.41c), len: 350 aa. Possible idsB, polyprenyl transferase (polyprenyl diphosphate synthase) (EC 2.5.1.-), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR GERANYL TRANSFERASE from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908, E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS GERANYL GERANYL DIPHOSPHATE SYNTHASE from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 PUTATIVE POLYPRENYL SYNTHETASE from Streptomyces coelicolor (378 aa), FASTA scores: opt: 779, E(): 5.3e-42, (44.45% identity in 324 aa overlap); Q9S5E9 FARNESYL, GERANYLGERANYL, GERANYLFARNESYL, HEXAPRENYL, HEPTAPRENYL DIPHOSPHATE SYNTHASE (SELF-HEPPS) from Synechococcus elongatus (324 aa), FASTA scores: opt: 563, E(): 2.3e-28, (39.85% identity in 241 aa overlap) (see citation below); O26156|IDSA_METTH|MTH50 BIFUNCTIONAL SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE [INCLUDES: FARNESYL PYROPHOSPHATE SYNTHETASE (EC 2.5.1.1) (FPP SYNTHETASE) (DIMETHYLALLYLTRANSFERASE) AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10)] from Methanobacterium thermoautotrophicum (325 aa), FASTA scores: opt: 540, E(): 6.5e-27, (35.75% identity in 319 aa overlap); P95999|GGPP_SULSO|GDS|GDS-1|SSO0061|C05010|C05_049 GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (GGPP SYNTHETASE) (GGPS) [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1)AND GERANYLTRANSTRANSFERASE (EC 2.5.1.10) AND FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Sulfolobus solfataricus (332 aa), FASTA scores: opt: 511, E(): 4.5e-25 (36.9% identity in 244 aa overlap); etc. Also similar to Q50727|GGPP_MYCTU|Rv3398c|MT3506|MTCY78.30 PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE [INCLUDES: DIMETHYLALLYLTRANSFERASE (EC 2.5.1.1); GERANYLTRANSTRANSFERASE (EC 2.5.1.10); FARNESYLTRANSTRANSFERASE (EC 2.5.1.29)] from Mycobacterium tuberculosis (359 aa), FASTA scores: opt: 687, E(): 3.4e-36, (39.1% identity in 325 aa overlap). Contains PS00723 Polyprenyl synthetases signature 1. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY." /codon_start=1 /transl_table=11 /product="POSSIBLE POLYPRENYL SYNTHETASE IDSB (POLYPRENYL TRANSFERASE) (POLYPRENYL DIPHOSPHATE SYNTHASE)" /protein_id="CAA15768.1" /db_xref="GI:2661662" /db_xref="GOA:O50410" /db_xref="InterPro:IPR000092" /db_xref="UniProtKB/TrEMBL:O50410" /translation="MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMRE PLATMAGYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSAAVELVH NFTLLHDDVMDGDATRRGRPTVWSVWGVGVAILLGDALHATAVRILTGLTDECVAVRA IRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKTAALTGCCCALGALVANAD DATIAALERFGHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSR SEAATELAALYQAPAAMTASDVERATALVKVAGGGHVAQRCADERIQAAIAALPDAVR SPDLIALSQLICRREC" misc_feature complement(330467..330511) /gene="idsB" /locus_tag="Rv3383c" /note="PS00723 Polyprenyl synthetases signature 1" gene complement(331580..331972) /locus_tag="Rv3384c" CDS complement(331580..331972) /locus_tag="Rv3384c" /function="UNKNOWN" /note="Rv3384c, (MTV004.42c), len: 130 aa. Hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt: 266, E(): 1.6e-10, (43.1% identity in 130 aa overlap); and Q50717|YY08_MYCTU|Rv3408|MTCY78.20c (136 aa), FASTA scores: opt: 243, E(): 4.8e-09, (35.1% identity in 131 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15769.1" /db_xref="GI:2661663" /db_xref="InterPro:IPR002716" /db_xref="UniProtKB/TrEMBL:O50411" /translation="MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEV MRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAGGLLPFELRTLDAIHLATAQRLG VDLGRLCTYDDRMRDAAKTLGMAVIAPS" gene complement(331972..332280) /locus_tag="Rv3385c" CDS complement(331972..332280) /locus_tag="Rv3385c" /function="UNKNOWN" /note="Rv3385c, (MTV004.43c), len: 102 aa. Hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 (99 aa), FASTA scores: opt: 155, E(): 0.001, (41.05% identity in 78 aa overlap); O07782|Rv0596c|MTCY19H5.26 (85 aa), FASTA scores: opt: 136, E(): 0.016, (39.45% identity in 71 aa overlap); P96916|Rv0626|MTCY20H10.07 (86 aa), FASTA scores: opt: 130, E(): 0.04, (51.2% identity in 41 aa overlap); etc. Also similar to PREVENT HOST DEATH (PHD) PROTEINS e.g. CAA66834|PHD from Escherichia coli (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap); and Q06253|PHD_BPP1 from Bacteriophage P1 (73 aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66 aa overlap)." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15770.1" /db_xref="GI:2661664" /db_xref="InterPro:IPR003756" /db_xref="InterPro:IPR006442" /db_xref="UniProtKB/TrEMBL:O50412" /translation="MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGR PVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPSVTLARLREHER " repeat_region 332324..333891 /note="IS1560-2, len: 1568 bp. Possible Insertion sequence element IS_1560. Second copy in MTCY10G2 from 11273 to 12919." /insertion_seq="IS1560-2" repeat_unit 332324..332348 /note="25 bp inverted repeat at the right end of putative IS1560, TAATTACTAGGACCTGAAAAAGTCG" gene 332429..333133 /locus_tag="Rv3386" CDS 332429..333133 /locus_tag="Rv3386" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS1560." /note="Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several IS element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13|Rv1036c from Mycobacterium tuberculosis (112 aa), FASTA scores: opt: 507, E(): 8.3e-25, (83.9% identity in 87 aa overlap)." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSPOSASE" /protein_id="CAA15771.1" /db_xref="GI:2661665" /db_xref="UniProtKB/TrEMBL:O50413" /translation="MFRTVGDQASLWESVLPEELRRLPEELARVDALLDDSAFFCPFV PFFDPRMGRPSIPMETYLRLMFLKFRYRLGYESLCREVTDSITWRRFCRIPLEGSVPH PTTLMKLTTRCGEDAVAGLNEALLAKAASEKLLRTNKVRADTTVVEGDVGYPTDTGLL AKAVGSMARTVARIKAADAGSAPLGGSSGPRDRLQAAVTRRAATRSGAGLRAPDHRGA SRDRRAGADRGCRGGT" gene 333123..333800 /locus_tag="Rv3387" CDS 333123..333800 /locus_tag="Rv3387" /function="INVOLVED IN THE TRANSPOSITION OF THE INSERTION SEQUENCE IS1560." /note="Rv3387, (MTV004.45), len: 225aa. Possible transposase, showing very weak similarity to other IS element proteins, and similar to various hypothetical proteins." /codon_start=1 /transl_table=11 /product="POSSIBLE TRANSPOSASE" /protein_id="CAA15772.1" /db_xref="GI:2661666" /db_xref="GOA:O50414" /db_xref="InterPro:IPR002559" /db_xref="UniProtKB/TrEMBL:O50414" /translation="MVRNAQRAVRRASGRRKAWLRQAINHLEKLIGRTERVVDQARSR LAGVMPDSSSRLVSLHDADARPIRKGRLGKPVEFGYKAQVVDNADGVILDHSVELGNP ADAPQLAPAIERISRRTGRPPRAVTADRGCGDASVEDDLHQLGVRNVAIPRKSKPSAT RRAFEHRRAFRDKIKWRTGSEGRINHLKRSYGWNRTELTGITGARTWCGHGVFAHNLV KISTLAA" repeat_unit complement(333867..333891) /note="25 bp inverted repeat at the right end of putative IS1560, TAATTACTAAGACCTGAAAAAGTCG" gene 333990..336185 /gene="PE_PGRS52" /locus_tag="Rv3388" CDS 333990..336185 /gene="PE_PGRS52" /locus_tag="Rv3388" /function="UNKNOWN" /note="Rv3388, (MTV004.46), len: 731 aa. Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to many PE-family proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53553|YZ08_MYCTU|RV3508|MTV023.15 (1901 aa), FASTA scores: opt: 2380, E(): 3.6e-87, (53.8% identity in 773 aa overlap); and MTV023_21, MTV023_18, MTV023_14, MTV039_16, MTCY441_4." /codon_start=1 /transl_table=11 /product="PE-PGRS FAMILY PROTEIN" /protein_id="CAE55593.1" /db_xref="GI:38490366" /db_xref="InterPro:IPR000084" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR002952" /db_xref="UniProtKB/TrEMBL:Q6MWX5" /translation="MSFVIANPEMLAAAATDLAGIRSAISAATAAAAAPTIQVAAAGA DEVSLAISALFGQHAQAYQALSAQATIFHDQFVQALTSGGNLYAAAESHTVEQMVLNA INAPTQTLFGRPLIGDGANGTAENPDGQNGGLLFGNGGNGFTQTTAGVAGGNGGSAGL IGNGGAGGGGGAGAAGGLGGNGGWLYGNGGAGGIGGAGTGTGGHGGAGGAGGRAWLWG TGGAGGAGGDGGWLFGDGGAGGTGGNGGSGFNSLTSSVGGAGGAGGHAGLFGAGGTGG TGGIGGQNTETGPAASNGGAGGAGGGGGYLVGDGGAGGTGGAGGKNSSGGATLTGGTG GTGGAGGAAGWLYGSGGAGGAGGAGGLNNAGGATGGTGGTGGAGGSGAWLYGNGGAAG AGGNGGNNTSAGTGGVGASGGTGGNAGLIGAGGHGGAGGAGGNQTGGVGNGGAGGNGG AGGAGGQLYGNGGDGGNGGAGGANIAGGNGSDGGAAGHGGAGGSARLIGAGGHGGDGG AGGNTAGRRADAIAGTGGDGGNGGNGGLLSGNAGAGGHGGAGGSSTATTTTGTPPTGA TGGNGGNGGAGGTAGFTGSGGIGGNGGAGGTGGNAGVALSVGSTGGLGGNGGSGGLGG GGGSLFGNGGAGGVGATGGNGGSGIGPASVGGNGGKGGVGAAGGLAGQIGNGGSGGSG GAGGNGGTGDTAGNGGNGGAGAVGGNAQLIGNGGNGGGGGNGGTGADGT" gene complement(336256..337128) /locus_tag="Rv3389c" CDS complement(336256..337128) /locus_tag="Rv3389c" /EC_number="1.-.-.-" /function="UNKNOWN; PROBABLY INVOLVED IN CELLULAR METABOLISM." /experiment="experimental evidence, no additional details recorded" /note="Rv3389c, (MTV004.47c), len: 290 aa. Possible dehydrogenase (EC 1.-.-.-), similar to parts of several bacterial dehydrogenases and eukaryotic short-chain dehydrogenases involved in steroid biosynthesis e.g. Q9UVH9|FOX2 FOX2 PROTEIN (a multifunctional protein of the peroxisomal beta-oxidation) (SIMILAR TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY) from Glomus mosseae (1015 aa), FASTA scores: opt: 649, E(): 7.5e-33, (40.9% identity in 269 aa overlap); Q9L009|SCC30.12c PUTATIVE DEHYDROGENASE from Streptomyces coelicolor (333 aa), FASTA scores: opt: 602, E(): 2.7e-30, (40.35% identity in 305 aa overlap); AAH03098 HYDROXYSTEROID (17-BETA) DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); P51659|DHB4_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE 4 from Homo sapiens (Human) (736 aa), FASTA scores: opt: 592, E(): 2.1e-29, (41.55% identity in 272 aa overlap); Q19058|E04F6.3 HYDRATASE-DEHYDROGENASE-EPIMERASE from Caenorhabditis elegans (298 aa), FASTA scores: opt: 573, E(): 1.6e-28, (41.0% identity in 266 aa overlap); O42484 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE IV from Gallus gallus (Chicken) (735 aa), FASTA scores: opt: 573, E(): 3.2e-28, (39.8% identity in 279 aa overlap); etc. And also similar in part to Q9LBK1|PHAJ2|PA1018 (R)-SPECIFIC ENOYL-CoA HYDRATASE from Pseudomonas aeruginosa (288 aa), FASTA scores: opt: 601, E(): 2.7e-30, (40.5% identity in 294 aa overlap). And similar to P71863|UFAA2|Rv3538|MTCY03C7.18c HYPOTHETICAL 30.2 KDA PROTEIN from Mycobacterium tuberculosis (286 aa), FASTA scores: opt: 609, E(): 8.7e-31, (39.65% identity in 285 aa overlap). HAS SOME SIMILARITY TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY." /codon_start=1 /transl_table=11 /product="POSSIBLE DEHYDROGENASE" /protein_id="CAA15774.1" /db_xref="GI:2661668" /db_xref="GOA:Q11198" /db_xref="InterPro:IPR002539" /db_xref="UniProtKB/TrEMBL:Q11198" /translation="MAIDPNSIGAVTEPMLFEWTDRDTLLYAIGVGAGTGDLAFTTEN SHGIDQQVLPTYAVICCPAFGAAAKVGTFNPAALLHGSQGIRLHAPLPAAGKLSVVTE VADIQDKGEGKNAIVVLRGRGCDPESGSLVAETLTTLVLRGQGGFGGARGERPAAPEF PDRHPDARIDMPTREDQALIYRLSGDRNPLHSDPWFATQLAGFPKPILHGLCTYGVAG RALVAELGGGVAANITSIAARFTKPVFPGETLSTVIWRTEPGRAVFRTEVAGSDGAEA RVVLDDGAVEYVAG" gene 337202..337912 /gene="lpqD" /locus_tag="Rv3390" CDS 337202..337912 /gene="lpqD" /locus_tag="Rv3390" /function="UNKNOWN" /experiment="experimental evidence, no additional details recorded" /note="Rv3390, (MTV004.48), len: 236 aa. Probable lpqD, a conserved lipoprotein with some similarity to various bacterial proteins e.g. Q9F3Q7|SC10F4.03 PUTATIVE ISOMERASE from Streptomyces coelicolor (224 aa), FASTA scores: opt: 416, E(): 2.5e-18, (33.0% identity in 197 aa overlap); Q9ZAX0|PGM 2,3-PDG DEPENDENT PHOSPHOGLYCERATE MUTASE from Amycolatopsis methanolica (205 aa), FASTA scores: opt: 314, E(): 3.7e-12, (28.55% identity in 203 aa overlap); P73454|SLR1748 HYPOTHETICAL 24.2 KDA PROTEIN from Synechocystis sp. strain PCC 6803 (214 aa), FASTA scores: opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa overlap); etc. Also similar to Mycobacterium tuberculosis hypothetical proteins e.g. O53817|Rv0754|MTV041.28 PGRS-FAMILY PROTEIN (584 aa), FASTA scores: opt: 219, E(): 5.1e-06, (39.8% identity in 226 aa overlap). Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site." /codon_start=1 /transl_table=11 /product="PROBABLE CONSERVED LIPOPROTEIN LPQD" /protein_id="CAA15775.1" /db_xref="GI:2661669" /db_xref="GOA:O50416" /db_xref="InterPro:IPR001345" /db_xref="UniProtKB/TrEMBL:O50416" /translation="MAKRTPVRKACTVLAVLAATLLLGACGGPTQPRSITLTFIRNAQ SQANADGIIDTDMPGSGLSADGKAEAQQVAHQVSRRDVDSIYSSPMAADQQTAGPLAG ELGKQVEILPGLQAINAGWFNGKPESMANSTYMLAPADWLAGDVHNTIPGSISGTEFN SQFSAAVRKIYDSGHNTPVVFSQGVAIMIWTLMNARNSRDSLLTTHPLPNIGRVVITG NPVTGWRLVEWDGIRNFT" misc_feature 337247..337279 /gene="lpqD" /locus_tag="Rv3390" /note="PS00013 Prokaryotic membrane lipoprotein lipid attachment site" gene 337958..339910 /gene="acrA1" /locus_tag="Rv3391" CDS 337958..339910 /gene="acrA1" /locus_tag="Rv3391" /EC_number="1.2.1.-" /function="UNKNOWN; INVOLVED IN CELLULAR METABOLISM" /experiment="experimental evidence, no additional details recorded" /note="Rv3391, (MTV004.49), len: 650 aa. Possible acrA1, multi functional protein with fatty acyl-CoA reductase activity in C-terminal part (EC 1.2.1.-). Indeed C-terminal part highly similar to P94129|ACR1 FATTY ACYL-CoA REDUCTASE from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 767, E(): 1.4e-36, (45.4% identity in 260 aa overlap); and similar to other oxidoreductases dehydrogenases/reductases e.g. Q9Y3A1 CGI-93 PROTEIN (SIMILARITY WITH SDR FAMILY) from Homo sapiens (Human) (291 aa), FASTA scores: opt: 363, E(): 1.5e-13, (38.65% identity in 194 aa overlap); Q9L146|SC6D11.09 PUTATIVE OXIDOREDUCTASE (SIMILARITY WITH SDR FAMILY) from Streptomyces coelicolor (343 aa), FASTA scores: opt: 346, E(): 1.6e-12, (30.4% identity in 283 aa overlap); Q9HSR4|YUSZ1|VNG0115G OXIDOREDUCTASE from Halobacterium sp. strain NRC-1 (260 aa), FASTA scores: opt: 338, E(): 3.7e-12, (33.85% identity in 248 aa overlap); etc. C-terminus also similar to Mycobacterium tuberculosis proteins Q10783|YF43_MYCTU|Rv1543|MTCY48.22c PUTATIVE OXIDOREDUCTASE (341 aa), FASTA scores: opt: 787, E(): 1.2e-37, (39.8% identity in 319 aa overlap); O06413|Rv0547c|MTCY25D10.26c HYPOTHETICAL 31.8 KDA PROTEIN (294 aa), FASTA scores: opt: 565, E(): 4.7e-25, (36.8% identity in 242 aa overlap); O53398|Rv1050|MTV017.03 OXIDOREDUCTASE (SDR FAMILY) (301 aa), FASTA scores: opt: 436, E(): 1.1e-17, (32.2% identity in 292 aa overlap). N-terminus (aa 1-320) is similar to P37693|HETM_ANASP polyketide synthase hetM from Anabaena sp. (506 aa), FASTA scores: opt: 188, E(): 1.3e-07, (27.7% identity in 361 aa overlap); so certainly a multi-domain enzyme. SEEMS TO BELONG TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Note that this ORF corresponds to the gene ORF2|Q11197 (see Yuan et al., 1995), but longer 266 aa, due to use of a more upstream start site." /codon_start=1 /transl_table=11 /product="POSSIBLE MULTI-FUNCTIONAL ENZYME WITH ACYL-CoA-REDUCTASE ACTIVITY ACRA1" /protein_id="CAA15776.1" /db_xref="GI:2661670" /db_xref="GOA:O50417" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR002347" /db_xref="UniProtKB/TrEMBL:O50417" /translation="MRYVVTGGTGFIGRHVVSRLLDGRPEARLWALVRRQSLSRFERL AGQWGDRVRPLVGDLTELELSERTIAELGDIDHVLHCAAVHDTTWADATRAVIELAAR LDATFHHVSSIAVAGDFAGHYTEADFDVGQRLPTPYHRMTFEAERLVRSTPGLRYRIY RPAVVVGDSRTGEMDTIDGPYYLFGVLAKLAVLPSFTPMLLPDIGRTNIVPVDYVADA LVALMHADGRDGQTFHLTAPTAIGLRGIYRGIAGAAGLPPLLGTLPGFVAAPVLNARG RAKVLRNMAATQLGIPAEIFDVVGCAPTFTSDTTREALRGTGIHVPEFATYAPGLWRY WAEHLDPDRARRNDPLLGRHVIITGASSGIGRASAIAVAKRGATVFALARNGNALDEL VTEIRAHGGQAHAFTCDVTDSASVEHTVKDILGRFDHVDYLVNNAGRSIRRSVVNSTD RLHDYERVMAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQARNPKYSSYLPTKA ALDAFADVVASETLSDHITFTNIHMPLVATPMIVPSRRLNPVRAISAERAAAMVIRGL VEKPARIDTPLGTLAEAGNYVAPRLSRRILHQLYLGYPDSAAAQGISRPDADRPPAPR RPRRSARAGVPRPLRRLGRLVPGVHW" gene complement(339911..340774) /gene="cmaA1" /locus_tag="Rv3392c" CDS complement(339911..340774) /gene="cmaA1" /locus_tag="Rv3392c" /EC_number="2.1.1.79" /function="HAS CYCLOPROPANE FUNCTION. TRANSFERS A METHYLENE GROUP FROM S-ADENOSYL-L-METHIONINE TO THE CIS DOUBLE BOND OF AN UNSATURATED FATTY ACID CHAIN RESULTING IN THE REPLACEMENT OF THE DOUBLE BOND WITH A METHYLENE BRIDGE. MYCOLIC ACIDS, WHICH REPRESENT THE MAJOR CONSTITUENT OF MYCOBACTERIAL CELL WALL COMPLEX, ACT AS SUBSTRATES [CATALYTIC ACTIVITY: S-ADENOSYL-L-METHIONINE + PHOSPHOLIPIDOLEFINIC FATTY ACID = S-ADENOSYL-L-HOMOCYSTEINE + PHOSPHOLIPID CYCLOPROPANE FATTY ACID]." /experiment="experimental evidence, no additional details recorded" /note="Rv3392c, (MTV004.50), len: 287 aa. cmaA1, cyclopropane mycolic acid synthase 1 (EC 2.1.1.79), characterized in 1995 as CFA1_MYCTU|Q11195|CMAA1|CMA1 cyclopropane-fatty-acyl-phospholipid synthase 1 (see citations below). Highly similar to Mycobacterium tuberculosis proteins MTCY20H10.23c (58.7% identity in 286 aa overlap); MTCY20H10.24c (68.6% identity); MTCY20H10.25c (73.5% identity); MTCY20H10.26c (57.0% identity); and MTCY20G9.30c (55.7% identity). Also highly similar to Q9CBK3|MMAA4|ML1903 METHYL MYCOLIC ACID SYNTHASES from Mycobacterium leprae (298 aa), FASTA scores: opt: 1098, E(): 1e-63, (57.0% identity in 286 aa overlap). Equivalent to AAK44898|MT0672 from Mycobacterium tuberculosis strain CDC1551 (317 aa) but shorter 30 aa and with some differences in residues between the proteins." /codon_start=1 /transl_table=11 /product="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 CMAA1 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC ACID SYNTHASE 1)" /protein_id="CAA15777.1" /db_xref="GI:2661671" /db_xref="GOA:Q11195" /db_xref="InterPro:IPR000051" /db_xref="InterPro:IPR001601" /db_xref="InterPro:IPR003333" /db_xref="UniProtKB/Swiss-Prot:Q11195" /translation="MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT LQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANH VQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPA DGVMLLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASAN GFTVTRVQSLQPHYAKTLDLWSAALQANKGQAIALQSEEVYERYMKYLTGCAEMFRIG YIDVNQFTCQK" gene 340798..341724 /gene="iunH" /locus_tag="Rv3393" CDS 340798..341724 /gene="iunH" /locus_tag="Rv3393" /EC_number="3.2.2.-" /function="INVOLVED IN PURINE SALVAGE. CATALYZES THE HYDROLYSIS OF ALL OF THE COMMONLY OCCURRING PURINE AND PYRIMIDINE NUCLEOSIDES INTO RIBOSE AND THE ASSOCIATED BASE, AND COULD HAVE A PREFERENCE FOR INOSINE AND URIDINE AS SUBSTRATES [CATALYTIC ACTIVITY: A N-D-RIBOSYLPURINE + H(2)O = A PURINE + D- RIBOSE]." /note="Rv3393, (MTV004.51), len: 308 aa. Probable iunH, nucleoside hydrolase (EC 3.2.2.-), similar to others e.g. Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA scores: opt: 497, E(): 6e-24, (34.3% identity in 312 aa overlap); Q27546|IUNH_CRIFA from Crithidia fasciculata (314 aa), FASTA scores: opt: 475, E(): 1.4e-22, (31.45% identity in 318 aa overlap); Q9CK67|IUNH from Pasteurella multocida (310 aa), FASTA scores: opt: 464, E(): 6.9e-22, (30.9% identity in 314 aa overlap); Q9A549|CC2615 from Caulobacter crescentus (323 aa), FASTA scores: opt: 464, E(): 7.2e-22, (37.85% identity in 280 aa overlap); etc. Note that also similar to BAB34113|ECS0690 (alias AAG54985|YBEK) PUTATIVE TRNA SYNTHETASE from Escherichia coli strain O157:H7 (311 aa), FASTA scores: opt: 483, E(): 4.5e-23, (33.0% identity in 315 aa overlap). The active site histidine is conserved." /codon_start=1 /transl_table=11 /product="PROBABLE NUCLEOSIDE HYDROLASE IUNH (PURINE NUCLEOSIDASE)" /protein_id="CAA15778.1" /db_xref="GI:2661672" /db_xref="GOA:O50418" /db_xref="InterPro:IPR001910" /db_xref="UniProtKB/TrEMBL:O50418" /translation="MSVVFADVDTGIDDALAVIYLLASPDADLVGIASTGGNIAVGQV CANNLSLLELCGAADIPVSKGADEPLGGRWPDHPKFHGPKGIGYAELPASNRRLTDYD ATTAWIAAAHSHAGDLIGLVTGPLTNLALALRAEPALPRLLRRLVIMGGMFDGQPITE WNIRVDPEAASEVFTAWAGQRQLPIVCGLDLTRRVAMTPDILARLASVCGSSPVMRVI EDALRFYFESHEARGHGYLAYMHDPLAAAVAMDPELLTTRTATVDVDPTGATVTDWSG KRNPNARIGMSVDPAVFFDRFVERIGRFARRT" gene complement(341779..343362) /locus_tag="Rv3394c" CDS complement(341779..343362) /locus_tag="Rv3394c" /function="UNKNOWN" /note="Rv3394c, (MTV004.52c), len: 527 aa. Hypothetical protein, with some similarity to various bacterial proteins e.g. BAB51085|MLR4427 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (545 aa), FASTA scores: opt: 267, E(): 2.8e-08, (26.5% identity in 509 aa overlap); BAB48362|MLR0866 DNA DAMAGE INDUCIBLE PROTEIN P from Rhizobium loti (Mesorhizobium loti) (438 aa), FASTA scores: opt: 245, E(): 4.6e-07, (25.5% identity in 290 aa overlap); Q9S292|SCI11.27c HYPOTHETICAL PROTEIN from Streptomyces coelicolor (322 aa), FASTA scores: opt: 202, E(): 0.00012, (28.5% identity in 323 aa overlap); etc. Also similarity with P95102|DINP|RV3056|MTCY22D7.25c HYPOTHETICAL PROTEIN from Mycobacterium tuberculosis (346 aa), FASTA scores: opt: 211, E(): 3.9e-05, (26.45% identity in 306 aa overlap). Equivalent to AAK47838 from Mycobacterium tuberculosis strain CDC1551 (492 aa) but longer 35 aa." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15779.1" /db_xref="GI:2661673" /db_xref="GOA:O50419" /db_xref="InterPro:IPR001126" /db_xref="UniProtKB/TrEMBL:O50419" /translation="MMASARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACS ATARAAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAELLRPG LLVLPVRGPARFFGSEQMAAERLIDAVAAAGAECQVGIADRLSTAVFAARAGRIVEPG GDARFLSLLSIRQLATEPSLSGPGRDDLTDLLWRMGIRTIGQFAALSRTDVASRFGAD AVAAHRFARGEPERAPCGREPPPDLAAELACDPPIDRVDAAAFAGRSLAAELHRALMA AGVGCTRLAIHAVTANGEERSRVWRCAEPLTEDATADRVRWQLDGWLNNRNARDRPTA AVTLLRLQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPEAVRVPVLSG GHGPAERITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAVLFDDPVDLLDAQGNPIR VTSRGMFSADPARLRVRGRDDRLRWWAGPWPDDERWWDPDRASGRTARAQVLLDGDPG TALLLCYRQRRWYLEGSYE" gene complement(343359..343973) /locus_tag="Rv3395c" CDS complement(343359..343973) /locus_tag="Rv3395c" /function="UNKNOWN. THOUGHT TO BE REGULATED BY Rv2720|LEXA." /experiment="experimental evidence, no additional details recorded" /note="Rv3395c, (MTCY78.33), len: 204 aa. Conserved hypothetical protein, with some similarity with RECA PROTEINS (RECOMBINASES A) e.g. P16238|RECA_THIFE from Thiobacillus ferrooxidans (346 aa), FASTA scores: opt: 131, E(): 1.1, (31.45% identity in 140 aa overlap); Q59560|RECA_MYCSM from Mycobacterium smegmatis (349 aa), FASTA scores: opt: 121, E(): 4.4, (30.25% identity in 129 aa overlap); etc. Note that shortened since first submission to avoid overlap with Rv3395A. Equivalent to AAK47839 from Mycobacterium tuberculosis strain CDC1551 (227 aa) but shorter 23 aa." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAA15780.2" /db_xref="GI:38490367" /db_xref="GOA:Q50730" /db_xref="UniProtKB/Swiss-Prot:Q50730" /translation="MTAAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVP AGPVSLPPGTVGVLSGARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRL AVIPDPGTDPVEVAAVLIDGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGD WQGVSTRLAARVCGYEITPALRGVPTPGLGRISGVRLQINGRGR" gene 344056..344682 /locus_tag="Rv3395A" CDS 344056..344682 /locus_tag="Rv3395A" /function="UNKNOWN" /note="Rv3395A, len: 208 aa. Probable membrane protein, with potential transmembrane stretches from aa 7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C PUTATIVE LIPOPROTEIN from Streptomyces coelicolor (258 aa), FASTA scores: opt: 107, E(): 7.4, (34.05% identity in 94 aa overlap)." /codon_start=1 /transl_table=11 /product="PROBABLE MEMBRANE PROTEIN" /protein_id="CAE55594.1" /db_xref="GI:38490368" /db_xref="UniProtKB/TrEMBL:Q6MWX4" /translation="MQSRKTTSVLAAALLFCGLLGPGTAPPATGGGPACRPAELFATD NTTDGFELPAVATIALTGTVVTGSTLVDGVFWSNERQQIGYERSREFHLCVVDAPTLH NAAEALHRQFNQEAVLTFDYLPQNAPEADAILITVPDIGIARFRDAFASDLAAHHRLR GGSVTTADHTLILVAGNGDLDVARRLVEEAGGDWNATTIAHGRREFVN" gene complement(344838..346415) /gene="guaA" /locus_tag="Rv3396c" CDS complement(344838..346415) /gene="guaA" /locus_tag="Rv3396c" /EC_number="6.3.5.2" /function="INVOLVED IN GMP BIOSYNTHESIS [CATALYTIC ACTIVITY: ATP + XANTHOSINE 5'-PHOSPHATE + L-GLUTAMINE + H(2)O = AMP + PYROPHOSPHATE + GMP + L-GLUTAMATE]." /experiment="experimental evidence, no additional details recorded" /note="Rv3396c, (MTCY78.32), len: 525 aa. Probable guaA, gmp synthase (EC 6.3.5.2) (see citation below), equivalent to P46810|GUAA_MYCLE|ML0395|B1620_C2_205 GMP SYNTHASE [GLUTAMINE-HYDROLYZING] from Mycobacterium leprae (529 aa), FASTA scores: opt: 2992, E(): 8.5e-168, (86.85% identity in 525 aa overlap). Also highly similar to others e.g. O52831|GUAA_CORAM from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (524 aa), FASTA scores: opt: 2636, E(): 5.9e-147, (76.2% identity in 521 aa overlap); Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526 aa), FASTA scores: opt: 2451, E(): 4.1e-136, (71.55% identity in 513 aa overlap); Q9KF78|GUAA_BACHD from Bacillus Halodurans (513 aa), FASTA scores: opt: 1819, E(): 4.1e-99, (52.55% identity in 510 aa overlap); etc. Contains PS00442 Glutamine amidotransferases class-I active site. BELONGS TO THE TYPE-1 GLUTAMINE AMIDOTRANSFERASE FAMILY IN THE N-TERMINAL SECTION. AND BELONGS TO THE GMP SYNTHASE FAMILY IN THE C-TERMINAL SECTION." /codon_start=1 /transl_table=11 /product="PROBABLE GMP SYNTHASE [GLUTAMINE-HYDROLYZING] GUAA (GLUTAMINE AMIDOTRANSFERASE) (GMP SYNTHETASE)" /protein_id="CAB01027.1" /db_xref="GI:1449391" /db_xref="GOA:P0A5A1" /db_xref="InterPro:IPR000991" /db_xref="InterPro:IPR001317" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR006220" /db_xref="UniProtKB/Swiss-Prot:P0A5A1" /translation="MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVI PHTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQA LGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAG APVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQ VRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFV AATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLV QGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVL LADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVN RVVLDITSKPPATIEWE" misc_feature complement(346119..346154) /gene="guaA" /locus_tag="Rv3396c" /note="PS00442 Glutamine amidotransferases class-I active site" gene complement(346427..347335) /gene="phyA" /locus_tag="Rv3397c" CDS complement(346427..347335) /gene="phyA" /locus_tag="Rv3397c" /EC_number="2.5.1.-" /function="INVOLVED IN CAROTENOID BIOSYNTHESIS AND IN ASTAXANTHIN BIOSYNTHETIC PATHWAY. CATALYSES THE REACTION FROM PREPHYTOENE DIPHOSPHATE TO PHYTOENE [CATALYTIC ACTIVITY 1: 2 GERANYLGERANYL DIPHOSPHATE = PYROPHOSPHATE + PREPHYTOENE DIPHOSPHATE] [CATALYTIC ACTIVITY 2: PREPHYTOENE DIPHOSPHATE = PYROPHOSPHATE + PHYTOENE]." /standard_name="crtB" /note="Rv3397c, (MTCY78.31), len: 302 aa. Probable phyA (alternate gene name: crtB), phytoene synthase (EC 2.5.1.-), similar to many others e.g. Q9X7V5|SC6A5.09 from Streptomyces coelicolor (312 aa), FASTA scores: opt: 791, E(): 2.8e-43, (48.25% identity in 286 aa overlap); Q9RW07|DR0862 from Deinococcus radiodurans (325 aa), FASTA scores: opt: 482, E(): 1.5e-23, (35.25% identity in 292 aa overlap); Q9JRU9|NMB1168|NMB1130 from Neisseria meningitidis (serogroup B) (290 aa), FASTA scores: opt: 446, E(): 2.8e-21, (34.25% identity in 260 aa overlap); P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419 aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339 PUTATIVE POLY-ISOPRENYL TRANSFERASE (EC 2.5.1.) from Neisseria meningitidis (serogroup A) (290 aa), FASTA scores: opt: 450, E(): 1.6e-21, (34.6% identity in 260 aa overlap). And similar to crtB|O05424 PHYTOENE SYNTHASE from Mycobacterium marinum (319 aa), BLASTP scores: 113, E= 6e-24, Identities = 89/283 (31%) (see citation below). Contains PS01045 Squalene and phytoene synthases signature 2. BELONGS TO THE PHYTOENE/SQUALENE SYNTHETASE FAMILY." /codon_start=1 /transl_table=11 /product="PROBABLE PHYTOENE SYNTHASE PHYA" /protein_id="CAB01026.1" /db_xref="GI:1449390" /db_xref="GOA:P65860" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="UniProtKB/Swiss-Prot:P65860" /translation="MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALG RRIDDVADGELAPETKITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAEL IDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQ TNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAAD WYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAA AALASSVTCGPAHGPLPADLGSHPSH" misc_feature complement(346799..346876) /gene="phyA" /locus_tag="Rv3397c" /note="PS01045 Squalene and phytoene synthases signature 2" gene complement(347364..348443) /gene="idsA1" /locus_tag="Rv3398c" CDS complement(347364..348443) /gene="idsA1" /locus_tag="Rv3398c" /EC_number="2.5.1.1" /EC_number="2.5.1.10" /EC_number="2.5.1.29" /function="INVOLVED IN THE BIOSYNTHESIS OF MEMBRANE ETHER-LINKED LIPIDS. CATALYZES THE TRANS-ADDITION OF THE THREE MOLECULES OF IPP ONTO DMAPP TO FORM GERANYLGERANYL PYROPHOSPHATE WHICH IS A PRECURSOR OF THE ETHER-LINKED LIPIDS [CATALYTIC ACTIVITY1: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate] [CATALYTIC ACTIVITY2: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate] [CATALYTIC ACTIVITY3: Trans-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate]" /standard_name="idsA" /note="Rv3398c, (MTCY78.30), len: 359 aa. Probable idsA1, geranylgeranyl pyrophosphate synthetase (GGPP synthetase) including: dimethylallyltransferase (EC 2.5.1.1), geranyltranstransferase (EC 2.5.1.10), and farnesyltranstransferase (EC 2.5.1.29). Most similar to AE000797_3|O26156|Q53479 bifunctional short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrop (325 aa), FASTA scores: opt: 605, E(): 0, (37.1% identity in 329 aa overlap); homology suggests ATG at 30121 or TTG at 30145 to be the initiation codon. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY; BELONGS TO A FAMILY THAT GROUPS TOGETHER FPP SYNTHETASE, GGPP SYNTHETASE AND HEXAPRENYL PYROPHOSPHATE SYNTHETASE. Note that previously known as idsA." /codon_start=1 /transl_table=11 /product="PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE): DIMETHYLALLYLTRANSFERASE (PRENYLTRANSFERASE) (GERANYL-DIPHOSPHATE SYNTHASE) + GERANYLTRANSTRANSFERASE (FARNESYL-DIPHOSPHATE SYNTHASE) (FARNESYL-PYROPHOSPHATE SYNTHETASE) (FARNESYL DIPHOSPHATE SYNTHETASE) (FPP SYNTHETASE) + FARNESYLTRANSTRANSFERASE (GERANYLGERANYL-DIPHOSPHATE SYNTHASE)" /protein_id="CAE55595.1" /db_xref="GI:38490369" /db_xref="GOA:P0A5H8" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="UniProtKB/Swiss-Prot:P0A5H8" /translation="MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADR LDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVE LVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVG AALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAG APRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVA HGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMV ARIGIPDRPAAELQDLAHYIVDRQA" misc_feature complement(347706..347744) /gene="idsA1" /locus_tag="Rv3398c" /note="PS00444 Polyprenyl synthetases signature 2" gene 348466..349512 /locus_tag="Rv3399" CDS 348466..349512 /locus_tag="Rv3399" /function="UNKNOWN" /note="Rv3399, (MTCY78.29c), len: 348 aa. Hypothetical protein, similar to other Mycobacterium tuberculosis (strains H37Rv and CDC1551) hypothetical proteins e.g. P95074|Rv0726c|MTCY210.45c (367 aa), FASTA scores: opt: 1188, E(): 7.7e-69, (60.05% identity in 308 aa overlap); MTCY31.21c (38.0% identity in 308 aa overlap), MTV041_5, MTCY4C12_14, MTY13D12_21, MTV043_22, MTCY210_44, MTCI5_19, MTCI5_20, MTV035_9, MTCY180_22, MTCY31_23, MTY13D12_1, MTCY180_29; etc." /codon_start=1 /transl_table=11 /product="CONSERVED HYPOTHETICAL PROTEIN" /protein_id="CAB01024.1" /db_xref="GI:1449388" /db_xref="InterPro:IPR003455" /db_xref="UniProtKB/Swiss-Prot:Q50726" /translation="MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMT RTDNDTWDLASSVGATATMIATARALASRAENPLINDPFAEPLVRAVGIDLFTRLASG ELRLEDIGDHATGGRWMIDNIAIRTKFYDDFFGDATTAGIRQVVILAAGLDTRAYRLP WPPGTVVYEIDQPAVIKFKTRALANLNAEPNAERHAVAVDLRNDWPTALKNAGFDPAR PTAFSAEGLLSYLPPQGQDRLLDAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSA AEAWRERGFDLDLTELIYFDQRNDVADYLAGSGWQVTTSTGKELFAAQGLPPFADDHI TRFADRRYISAVLK" ORIGIN 1 agcaacgcgg gcggcgctac gccgtggtca tcagccccgg ctcgatgccg tggagtgtag 61 taaccgtggt gccgacgtcg acaagcgccc aacctgcggt tttccgacca gagctggaag 121 tcatgggaac aaagacacgg ttcctggtgg atcagatccg gacgatcggc atcgtctatg 181 tgcacggcga tccggtcgac tatctggacc gtgaccaaat ggccaaggtg gaacacgccg 241 tggcacgata ccttggtctg tgatggccgt cgcatctgca aatgggccac cgacctggcc 301 cttcggtgga gctgccggga atcgaacccg ggtcctacgg cattccctca aggcttctcc 361 gtgcgcagtt cgctatgcct ctgctcggat ctcccggtca cgcgaactag ccgagatgac 421 gatcccagtc gctgtggttg tcccgaggag tcccgcgacc ggactcatcg gtggatccct 481 ctagctgatg ccagggtccg ggccgagggc gttcccggtc tgacagacta gccgtcgctt 541 aggcagcgag agcgtagtcg cgctgatgtg aatcggcgct tatttggtcg caacgacgct 601 tacggtggtc tcttgcctgc accggcacgc ttcccttgat tcgatgcgcg aagtcgaaac 661 cgttcagccc ctcgcatccc tgccgacctt cggcaggacc atcaatccta cgccgctctc 721 aacaaccggc aacgccatta acttcccggt cagatcacga agttcaggcg ctcgaggatg 781 tgaccggcca gctccttgtc gccgccgagt tccacatcct ggctgcgcgc cgggctcatc 841 gggcgcccgc cggcgagcct ggtgaactgc agtccgtcca ggcggatcgt cgccgtcggc 901 gccggcccac cgaagtcgtc gaccacccgc gctcgaccgt ccacggaaac gcggatgctg 961 cgagacagcg ggccggtcag ctccaacagc acgcgggagc cgtcgggcgc tttggccagc 1021 ttgccgacga cgaaccccat ggtggccgct atctcatcga ggaccagcgg tgacgccggc 1081 ccgccgagtt cgtcgtcgga cgacgggcgc tgcaccgccg cgcggatgtc ctgttcgtgc 1141 atccagcagt cgaagatgcg tatccgcatg aaccgcccgt agctgtcggg gcccgagggg 1201 gtggtcgtcg gcgcattcca ttcgtcatcg gaaaggctcg ctaagacctt gcggcgctgg 1261 ctagtcactg cgcgaaaccg ctccagcaag cccacacccg attctgtgcc cagatgacgc 1321 acccagcact cgttcatcac gccgatgggg ttgcggacat gcgcaagcgc agagacgtct 1381 gtgtctggtt ctggtgcggc gatgccgagc agaaatgact cggtgccgat gatgtgcgac 1441 accacggcct tgacgtccca accgggcagc ggactcgttg cctgccagtc cgtctcgagc 1501 agtccatcga gcagcgcatc cagggagtgc caaacggcga acagcccggc cagcacgtcg 1561 gacttgtcca gtgtggtaag gggacggccc ggtgtggtca caaagtgatg ctaaacctca 1621 cattgcccag ttctcgatca ggtcatgccc ttagcgcgcc gacccaactc gcggagcact 1681 tcacgctggg catcacgacg ggccatgtcc tggcgtttgt cgcgggcttg cttgcctcgg 1741 gccagcgcaa gctcaacctt gaccttgcct tcggcgaaat acagcgacaa cggcaccagg 1801 gcgaagttgc cttcgcggat cttgccgacc aaggtgtcga tctggcggcg atgcaacagc 1861 agtttgcggt tgcgtcgcgg ctcgtggttg gtccagctgc cgtgccggta ttccgggatg 1921 tgcgcgttgc gcagccacac ttcgccgtcg tcgatggtgg cgaacgaatc ggccagcgac 1981 gcctgccctt cccgcaggct cttcacctcc gtgccttgca gcgcaacccc ggcctcgaac 2041 acctcgatga tcgaatagtt gtgccgggct ttgcgattgc tggcaacgat ctgccggccg 2101 ccacgcgacg acttggacac agctatcgcc gcacgtagag gcgcagcgtt aagtaagccg 2161 tcaaccccga catcgccacg cccaacagca gcagccacgg cgtgatgaag aggatgtccg 2221 catagtcaac cttggcaatg agattggctt gataaaactg gttgagcgca ttctccagga 2281 acaaagcccg caccaccatc aagcccgcta cggcgatgcc gacacccatc gtcgcggcca 2341 gcatcgcctc cactaggaac ggcagctggg tgtaccagcg gctggcaccg accaagcgca 2401 tgatgccgat ttcggtgcgc cgcgtatagg cagccacttg gaccatgttg gcgatcaaca 2461 gaatcgcccc gatggcctga accagcgcga ccgcgaacgc ggcattgctc aaaccatcaa 2521 ggaccgcgaa cagccggtca atcagctcct tttgattcag cacgtccaag acgccgggct 2581 gccccttcat agcggtgtca aagtccttgt gctgctcggg gttctccagc ttgacaatga 2641 acgacgccgg gaacgaatcc ttgcccgcca cgtccttgaa ctggggaaac ttgcggatgg 2701 catcgtcata ggcctgctgg cggttaagga aacgcaccgc tttgacgtcg gatcgcgttt 2761 cgatcttctc ccgtaacgct ttgcacgcag tggtatcgca ggacgagtcg ttggcggaaa 2821 cgtcttcggt gagaaagacc tgagattcca cccggtcgag atagatggcc cgggagctgt 2881 cggccaaccg gaccaccaac ataccgccgc cgaacaatcc gaccgagatc gcggtcgtca 2941 ggatcatcgc gatcgtcatg gtgacattgc gacgaaagcc ggtcaggacc tcatttagca 3001 ggaaaccgaa acgcacttag cgatccatcc cgtagacgcc acgctgttcg tcgcgtacca 3061 gcctgcccag ggacaactca accacccgtt ggcgcatcga gtcgacgatg tggtggtcgt 3121 gcgtggccat cagcaccgtc gtgccggtgc ggttgatccg ctccaataag tccatgatgt 3181 ccctactggt ctccgggtcg aggtttccgg tgggctcgtc ggccagcagt accagcggcc 3241 ggttgacaaa ggcgcgggcg atcgcaacgc gctgttgctc gccgcccgac agctcgtctg 3301 gcagccgatt ggccttgccg gacagaccga ccgtctcgag cacttcgggg accacccggt 3361 tgatcgcgtc ggtgcgtttg ccgatgacct ccaatgcgaa ggcgacgttg tcgtacaccg 3421 tcttctgctg cagcaaccga aagtcctgga agacgcagcc gatcacctga cgcagcttcg 3481 gtacgtggcg accgcggagt ttgttgacat gaaacttcga gacccggaca tcaccactgg 3541 tcggcgtctc cgctgccagc agcagccgca tgaaggttga cttgcccgaa cccgacgggc 3601 cgatcaggaa gacgaactca cccttgtcga tcttgacgtt gatgtcatcc aacgccggac 3661 gcgccgacga tttgtactgc ttggtgacat ggtccagggt gatcatcacg gcacgccagt 3721 gtagcggtga gattagcggg caggcgaaat caacgggtcg gtggctcgga tttggggtag 3781 gtgccggccg tcggacccgg cccgggctgc ggtagcggtg ccggtggtgt tggggtcgtg 3841 gtgcccgggc cgaacggcgg cggcaactca aacggcggcg ggacagccga atcggtcgtg 3901 gtttcgggcg ggctgaccgg cggtgtgctc gacgtggtgg tcggcgtcgc cttgacggtg 3961 ggtggttgca ctctggttcg cggcacccag gtgtagtcag gatcgggcac gaagcccggc 4021 ggcaccacct gggtcggcgg agagtcacca ggacctggtg cctgtggcct ataggtctcg 4081 taaatccacc acaccgccag gaacgcggcg atcaacacca gggtcgacgt gcggatccgg 4141 ccgaacagat agcccggcca gtgccgtttc tggttgctga gcttcacgct actgctccgg 4201 actttctgcc accgcggccc gcgcatcggc cgcggtgact atcccggcgc gggtgagcgc 4261 gcggatcacc agcacccgca actgccggcc cgcctcgaac tgcttgccgg gtagggtgcg 4321 ggccaccagt cgcagggtga cggtgtccac ttcgatgcgc tccacgccca tgaccgtggg 4381 ctcatccaac aacagctctc ccagcagcga gtcgtggcgc gcgtgctcac actcctgatg 4441 caagacctcg ttcacgcggc cgagatcggc gctggtcggg acggggatgt ccacgaccgc 4501 gcgggcccag tccttggaca ggttgaccga cttgacgatg ttcccgttgg gaacggtgaa 4561 cacctcaccc tcgctggaac gcagcttggt cacccgcagc gtgacgtcct ccaccgtgcc 4621 ggccgcgttc tccggtgacc ccaccatgct gagttcgacc aaatcgccga acccgtactg 4681 cttctccacg atgatgaaga acccggcgag taggtcctgc accaggcgtt gggcaccgaa 4741 gcccagcgcg gcgccgagca ccgccgccgg ccccaccaac gcaccgaccg gaaccggcaa 4801 cacatcgatg acctcgtaca caacgacgac atagatgagg acgatcgaca cccacgagat 4861 caccgacgct acggcctggc ggtgcttggt tgcctccgag cgcaccaacg cgtcgctttc 4921 ggtaaacccc aggtcgaggc gccgggtcac ccggttggca agccaagtca cgaagcgggc 4981 cgccagcacc gctgcgatca gcagcatgac gatgcgcagg ccccggttga ggatccagtc 5041 gccgatttca ccgcgccaga agttatgcca gtgctgtgct atcgaggtgg ccagaactgt 5101 gccgctagtc gtcattacgt cgattgcgcc accggatccc ggcttccagg aatccgtcga 5161 ggtctccatc cagaacggcc gccggattgc cgacctcgta ctcggtgcgc agatccttga 5221 ccatctgata tgggtgcagc acataggaac gcatctggtt accccaggag ctgccgccgt 5281 cggccttcaa cgcgtcgagc tcggcgcgtt cttctaagcg cttgcgttcc aacaactttg 5341 cttgcagaac ccgcatcgcc gcgatcttgt tctgcagttg ggacttctcg ttctggcagg 5401 tgaccacgat accgctggga atgtgggtga gccgcaccgc tgagtctgtc gtgttcaccg 5461 attgcccgcc gggcccgctg gagcgataga cgtcgacgcg gacatcgccc tcggggatgt 5521 caatgtggtc ggtggtctcc accaccggca gcacttcgac ttcggcgaac gacgtctgtc 5581 gccggctctg gttgtcgaac gggctgatcc gcaccagccg gtgggtgccc tgttcgaccg 5641 acaacgtgcc gtaggcgaac ggtgcgtgca cggcgaacgt ggcgcttttg atgccggctt 5701 cttcggcata ggaggtgtcg aacacctcga cggggtattt gtgctgctcg gcccagcgga 5761 tatacatccg catcagcatc tcggcccagt ctgcggcgtc caccccaccc gcgccggacc 5821 ggatggtgac cagcgcctca cgctcgtcgt attcccccga cagcagggtg cgcacctcgg 5881 tggcctcgat gtcggcgcgc aacgacttga gctccgcgtc ggcctcggcg acggcatcgg 5941 cggcggccgc gcccgcttcc tcggcggcca gctcgtagag caccggcagg tcgtccaggc 6001 ggcgccttag ctcctcgacg cgccgcagct ctccctgggt gtgcgacaac tcgctggtca 6061 cccgctgcgc ccgggtctgg tcgtcccaca agtgcggatc agatgcctca tgctcgagct 6121 tctcgatgcg gctgcgcaga ccctcgacgt cgagcacccg ctccaccgtg gtcagggtgc 6181 agtccaaggc ggcgatgtcg gcttgacggt cggggtccac agcagccaag gttaccggca 6241 tcagcgtcta gcatcagatg accgtcatgt gcaccgcacg actgcggccc agcccattcg 6301 cagccccttg cgccgcagcc gggcacaaca cagaggctcg agtatgcgtc cctattacat 6361 cgccatcgtg ggctccgggc cgtcggcgtt cttcgccgcg gcatccttgc tgaaggccgc 6421 cgacacgacc gaggacctcg acatggccgt cgacatgctg gagatgttgc cgactccctg 6481 ggggctggtg cgctccgggg tcgcgccgga tcaccccaag atcaagtcga tcagcaagca 6541 attcgaaaag acggccgagg acccccgctt ccgcttcttc ggcaatgtgg tcgtcggcga 6601 acacgtccag cccggcgagc tctccgagcg ctacgacgcc gtgatctacg ccgtcggcgc 6661 gcagtccgat cgcatgttga acatccccgg tgaggacctg ccgggcagta tcgccgccgt 6721 cgatttcgtc ggctggtaca acgcacatcc acacttcgag caggtatcac ccgatctgtc 6781 gggcgcccgg gccgtagtta tcggcaatgg aaacgtcgcg ctagacgtgg cacggattct 6841 gctcaccgat cccgacgtgt tggcacgcac cgatatcgcc gatcacgctt tggaatcgct 6901 acgcccacgc ggtatccagg aggtggtgat cgtcgggcgc cgaggtccgc tgcaggccgc 6961 gttcaccacg ttggagttgc gcgagctggc cgacctcgac ggggttgacg tggtgatcga 7021 tccggcggag ctggacggca ttaccgacga ggacgcggcc gcggtgggca aggtctgcaa 7081 gcagaacatc aaggtgctgc gtggctatgc ggaccgcgaa ccccgcccgg gacaccgccg 7141 catggtgttc cggttcttga cctctccgat cgagatcaag ggcaagcgca aagtggagcg 7201 gatcgtgctg ggccgcaacg agctggtctc cgacggcagc gggcgagtgg cggccaagga 7261 caccggcgag cgcgaggagc tgccagctca gctggtcgtg cggtcggtcg gctaccgcgg 7321 ggtgcccacg cccgggctgc cgttcgacga ccagagcggg accatcccca acgtcggcgg 7381 ccgaatcaac ggcagcccca acgaatacgt cgtcgggtgg atcaagcgcg ggccgaccgg 7441 ggtgatcggg accaacaaga aggacgccca agacaccgtc gacaccttga tcaagaatct 7501 tggcaacgcc aaggagggcg ccgagtgcaa gagctttccg gaagatcatg ccgaccaggt 7561 ggccgactgg ctagcagcac gccagccgaa gctggtcacg tcggcccact ggcaggtgat 7621 cgacgctttc gagcgggccg ccggcgagcc gcacgggcgt ccccgggtca agttggccag 7681 cctggccgag ctgttgcgga ttgggctcgg ctgatcagcg accgagcaac acccctgggt 7741 tgaggatccc ggccgggtcg agtgcggact tcgccgcccg cagggccgcc gcgaacgggt 7801 cgggacgctg ccggtcatac caagcgcggt ggtcgcgacc gaccgcatgg tggtgggtga 7861 tggtaccgcc actggcgctg atcgcctcgg acacggcagc cttgatctcg tcccactgcg 7921 cgtcgagcga cccccagcgc ccgccggcat agatgccgta gtaaggagcc gggccgtccg 7981 ggtagacatg ggtgaatcga caggtcacta ctccggtccc gcataccttc cagatcgcgg 8041 tccgagcggc atcggtcacc gcggcatgta gagtatcgaa tccgtcccag gtgcaagcgg 8101 tttcgaatgt ttcggcgata actccgcggc gaaccagcgc gtctcgttga tacggcatgc 8161 gcagaaacgc cgagcgccag ttcgcggctg cgttgtgttc cgttgcgtcg cttgtagttc 8221 cgcggctacg ttgcgcggtc accgtgccgc cgtgttcggc ggtgatcgcc accgcccggt 8281 gcagccacgg gtctatcggg tggtcggcag actcgaacgc caacaccaac agcccgccac 8341 caacggacgt gccggcattc agcaacgcct cggccggatc caacagccgg cagttggccg 8401 ggtacagccc cgcctgagcg atcgtccggg tcgcggcgac cgcggcggcc cagtcgtcaa 8461 acaccacgga caccgtgacc tgccatcgcg gacggtgttg cagccgcatc cacgcctcgg 8521 tgatgatgcc aagcgtcccc tcggacccga ggaacaaccg gtccggggat ggtccggcac 8581 cgcttccggg cagccgccgg gactcgctga tccccaccgg ggtgacaatc cgcagcgatt 8641 cggtcaagtc gtcgatatgg gtatagagcg tggcgaagtg tccgccggag cgggtggcca 8701 accagccacc gagagtcgag aagccgaagg actgcgggaa atggcgcagt gtcaaatcgt 8761 gtgggcgaag ctgatgctcg atcgaggggc cgaacgcacc cgcctggatg cgcgcggcac 8821 ggctgacacg gtcaatctca agcaccgcgc tcatggcagt gacgtcgacc gtgaccaccg 8881 gctcatcgaa gcgcggctcg acaccgccaa ccaccgagct gccaccaccg tatgggatga 8941 ccgcaatccc ctcgcgcgca caccaatcca gcacgtcgat cacgtcctgc tcgctgcggg 9001 gtcgggcgat gaggtcgggc aggtggtcga gctggccctg caggttgcgt gcgatgtcgc 9061 gatacgcttt gccgcgcgcg tgtccggccc gatcgacgag atcgcttgag cagagcgcgg 9121 ccagcgatgc cggcgggctg acccgtgggg ccgccaaacc gagcgcggtc aggtccggcg 9181 gcgggtggtc gctcaggtca tggccggaca ccagtgccgc gactcgcgac tgtagcgctt 9241 gcgtctcctg atcggagagc gcgtcctcga ctgtgcccca accccaccac gaacgcatgc 9301 tgatggtgtc agcgtttgag gacgatcatg gctccgccga cgaccaccag caccagggcc 9361 gcgacgatag cccatccagc accggctagc caccacatga cacccaatgc ggcgagtacc 9421 ggcgacagcg cgaagaacac cattaccggg tgctgcctaa tcactgcgag ggcactggtc 9481 gcccggactc gatcgatttc cttgcctggc atgcccttca ggatgccagc tgactaccac 9541 aatgcaagca gcgatgagcc gacgaaccgt catccttggc ctgctcccgc tcgctgttgt 9601 cgtcacgaat ggcgcacgat gcggcgcacc aatgcctgtg accgaaggcg gttcgggctg 9661 tcattgacaa ttcatgaaga tgcctgccgc atcatatccg ttgtgcccgt tgttctagaa 9721 gtccgacgtg ctgagcctgc ccacccggcg accccatatc cggaacccct cgcgcgctgc 9781 agccgctcac ctggtctgaa cgaaagctcg cacatgagtg gtcggattcc gccctaacaa 9841 cgcgccataa acgcaggctc atgcgctgcg ccacgatgcg ccgatgcatt tcggtaacga 9901 ttgttagtta acccttgtac gaaactctct tgaggcgctc taaccgactg cgtccaaagt 9961 ggaggatcga aaagatgata ggaaaatgag tacgcctacg ctgcctgata tggtagctcc 10021 atccccgaga gtgcgagtaa aagaccgttg tcgccggatg atgggggacc tacgcctttc 10081 cgttatcgat cagtgcaatt tgcgatgccg ttattgtatg cccgaagagc actacacatg 10141 gttgccgcgg caagatttgc tatccgtcaa agaaatcagc gccattgtag atgttttcct 10201 ttccgttggg gtaagtaaag ttcgaatcac cggtggcgaa ccgctgatcc gcccagattt 10261 gccggaaata gtgaggacat tgagcgcaaa ggtcggcgaa gattcaggtc tgagagactt 10321 agcgatcacg acgaacggcg tccttctcgc cgaccgcgtt gacggcctga aggctgcggg 10381 tatgaaacgc atcactgtca gtcttgatac gttgcaaccc gagcgcttca aggcgataag 10441 tcagcgtaat agccacgata aggtcatcgc gggtatcaag gctgtcgcag ccgcgggatt 10501 tacggacaca aaaatagaca caacggtgat gcgtggtgcc aatcacgatg agctggctga 10561 tctgatcgaa ttcgctcgga ctgttaacgc ggaagtcagg ttcattgagt acatggacgt 10621 cggcggcgca actcactggg catgggagaa ggtctttacc aaagcgaaca tgctcgagtc 10681 ccttgagaaa cggtatggac gtattgagcc tttgcccaaa catgatacgg cgcccgccaa 10741 tcgatatgcg cttccggacg gaactacctt cggaattatc gcgtcgacaa cggagccatt 10801 ctgcgcaacc tgtgaccgtt cacggttgac cgccgatggc ttatggctgc attgcttgta 10861 cgcaatatcg ggtatcaacc taagggagcc gctgcgtgca ggcgcgactc acgatgactt 10921 ggtggaaacc gtgacaaccg gatggcggcg acgaacggat cgcggagcag agcagcgtct 10981 tgcccaacgc gagcgcggag tgttcctgcc attaagcacg ttaaaggccg acccgcatct 11041 ggagatgcac accaggggcg ggtaagccga acgaacagtc gattgatcaa cgactccaca 11101 gttgaggaag gaaccatgac ggtcagcacc cctgagcaac acgagcaacg agcatcccac 11161 gatgcatccg agggaaagca caacgtatgt caggggaggc tggccgcact tgccgacgcg 11221 gccgtgtcag agaaactcgg agcactacct ggctggcagc ttctcgacat gcgactcagc 11281 cgcgcttttc agtgcacaaa tttcgaccaa tccattgact tcatgaatag ggtcgcatca 11341 atagcaaacg atatcaatca ccatcccgat atcgctgtac tggacaagcg ttcggtgcgc 11401 gtgacggcgt ggacgcgcaa gctgggctat ctgaccgaca tcgacttcga tcttgcggcg 11461 tccgtcgagg cgatgtatgc gacagaattc gctgacaggc cagcacgatg atcgaccatg 11521 cactcgcgct gacacatatc gatgagcgtg gtgcggcacg aatggtcgat gtgtccgaga 11581 aacccgtgac tttgagggtt gccaaagcgt cagggctcgt gatcatgaag ccgtctacct 11641 tgaggatgat ttccgacggt gccgctgcta agggtgacgt catggcggcg gcccggatag 11701 ctggcatcgc ggcggcgaaa cgtacgggtg atcttattcc gctatgccac ccgttagggc 11761 tcgacgctgt cagcgtcact atcacgccgt gcgagcctga ccgggtgaag attctggcga 11821 caaccaccac gctggggcgt accggcgtgg aaatggaagc gttgaccgca gtttcagtcg 11881 ccgccttgac tatctacgac atgtgcaaag ccgtcgatcg agccatggag atttctcaga 11941 tcgtgctcca agagaaaagc ggcggccggt ccggagttta tcgccgaagt gcttctgatt 12001 tggcctgtca gtcccgataa gtaggtgagt gtctgaatga ttaaagtgaa tgttctttac 12061 ttcggtgccg ttcgtgaggc gtgtgacgaa acgcctcggg aggaagtaga ggttcagaac 12121 ggtaccgatg tcgggaatct tgttgatcaa ctccagcaaa aataccctcg ccttcgcgat 12181 cattgtcagc gagtacagat ggcggtcaac caattcatcg cgccgctgtc gaccgttctc 12241 ggcgatggtg atgaggtcgc cttcatcccg caggtagccg gaggctgaac aaggggatga 12301 ccggccgtga atgcgctctc atcgtcgccg ctgttcggca acgtgggagt tccagtgccg 12361 gcgtgcagaa cgaccgaaat tcgccgcacc cgaatagtcg ggtcgcatag atgaccagca 12421 gggatggatt caccatcgtt tgggattgga acgggacgct gtgcgacgac cggacaattc 12481 ttctcgacgc ggttgggcag acgctggtca acgagggatt cgagcctctt tcgcaacagc 12541 agctgatcca acggttcgca cgcccactac gaacgttttt cgagaatgcg tgcggtcgag 12601 atctcttgac gtccgagtgg gaacgcgtcc aatccacctt tcgccgaatc tatcgatcgc 12661 gagaagctga agtcacactc gtcgaagatg cgtacgacgt tctggcgcag ggaaaccgca 12721 gcgccgctgg gcagttctta ttatcgctgg cgcctcacga cgagcttatg cacttcgtcc 12781 aaaaatacgg gattgccaag tggttcaacg gaatccgtgg ccggactcgg cccgaccaag 12841 aaaaacccat gatgctggca gaactgatca tgcagcgctc tctgaatccc actcgcgtgg 12901 tgcacatcgg cgattcgctt gaggacgccg ctgctgccag cgcggtcgga gccatttccg 12961 tcttggtcac cggagcttca ctgcagccac ccgaccgagt catgctcaaa cagttgcagc 13021 ccttcgttgc gagttcgctg aagcaagcac tgcagtacgc gggtggcgac ggtgattgac 13081 gacgaaggta cgcaggtggt ggcggcgcgc ctgccgttcg gatggtcagc cgacagtggg 13141 gtgacagccg acatcatcga ggcagcgatg gaacttgcga tcgacacagc gcgacatgcc 13201 acggcaccgt ttggcgctgc gctgcttgat gttacgacac tccgagcatt ctcgggtggc 13261 aacacctatt ttgaatcggg ggatcgcttc gctcacgccg aaaccaacgt tctacgggcc 13321 gcaatgagca cattgccgga gctttcaaat cacgtgctga tatccaccgc cgagccatgc 13381 ccgatgtgcg cggcggccag cgtgctcagc ggagtgagag ccatcatctt cggcacatca 13441 atcgagaccc ttatccagtg cggttggttc caaatccgca tcagcgcttc ggatgtggtg 13501 gcggcctcca ctcgtcccac gcgtccatcg gtgtatagcg gtttcctcag ccacaagacg 13561 gacttgttgt accggaactc cgaaaaccga cgagcaatga acccctggac cgatccatcg 13621 cattgactcg gcttgccgac tacctcactg acccaggagg agagttacgt ccaggggtgt 13681 ggtgtacggg caggtaaggc cggtgggcgt gtcgtagccc agtagtgggc ggtcatcgcg 13741 tgatccttcg aaacgaccag caaaagtcaa tcgaaggaaa tgacgcaatg acctcttctc 13801 atcttatcga cgccgagcag cttctggctg accaactcgc acaggcgagc ccggatctgc 13861 tgcgcgggct gctctcgacg ttcatcgccg ccttgatggg ggctgaagcc gacgccctgt 13921 gcggggcggg ctaccgcgaa cgcagcgatg agcggtccaa tcagcgcaac ggctaccgcc 13981 accgtgattt cgacacccgt gccgcaacca tcgacgtcgc gatccccaag ctgcgccagg 14041 gcagctattt cccggactgg ctgctgcagc gccgcaagcg agctgaacgc gcactgacca 14101 gcgtggtggc gacctgctac ctgctgggag tatccactcg ccggatggag cgcctggtcg 14161 aaacacttgg tgtgacaaag ctttccaagt cgcaagtgtc gatcatggcc aaagagctcg 14221 acgaagccgt agaggcgttt cggacccgcc cgctcgatgc cggcccgtat accttcctcg 14281 ccgccgacgc cctggtgctc aaggtgcgcg aggcaggccg cgtcgtcggg gtgcacacct 14341 tgatcgccac cggcgtcaac gccgagggct accgagagat cctgggcatc caggtcacct 14401 ccgccgagga cggggccggc tggctggcgt tcttccgcga cctggtcgcc cgcggcctgt 14461 ccggggtcgc gctggtcacc agcgacgccc acgccggcct ggtggccgcg atcggcgcca 14521 ccctgcccgc agcggcctgg cagcgctgca gaacccacta cgcagccaat ctgatggcag 14581 ccaccccgaa gccctcctgg ccgtgggtgc gcaccctgct gcactccatc tacgaccagc 14641 ccgacgccga atcagttgtt gcccaatatg atcgggtact cgacgctctg accgacaaac 14701 tccccgcggt ggccgagcac ctcgacaccg cccgcaccga cctgctggcg ttcaccgcct 14761 tccccaagca gatctggcgc caaatctggt ccaacaaccc ccaggaacgc ctcaaccgag 14821 aggtacgacg ccgaaccgac gtcgtgggca tcttccccga ccgcgcctcg atcatccgcc 14881 tcgtcggagc cgtcctcgcc gaacaacacg acgaatggat cgaaggacgg cgctacctgg 14941 gcctcgaggt cctcacccga gcccgagcag cactgaccag caccgaagaa cccgccaagc 15001 agcaaaccac caacacccca gcactgacca cctagactgc cacccgaagg atcacgcgag 15061 gaaccttcac tcgtacacca cgtccctggc cttggccagg aggagagcaa tcatgactga 15121 agccttgatc ccggcaccgt cgcagatatc gctgacccgc gatgaggtgc gcaggtacag 15181 caggcacctc atcatcccgg atatcggcgt caacggccaa cagcggctga aggatgcgcg 15241 cgtattgtgt atcggcgccg gaggattggg ttcgcctgct ctcctgtatc ttgcggccgc 15301 cggagtcggt accatcggca tcatcgatgg agaccacgtg gatgagtcga atctgcaacg 15361 ccaaatcatt catggcacat ccgacgtggg taggccgaaa gtagaatcag cagccgaggc 15421 ggtggcggaa atcaacccgc acgtccgggt gacgcaatat cgcgaaatgc tcacccacga 15481 caacgcactg gaaatttttg gcgatcacga cctcattgtt gacggcacag acaacttcac 15541 gacgcgctac ctgatcaatg atgccgcggt cttggccggc aaaccatatg tttgggggtc 15601 gatctaccga ttcaacggcc agaccagtgt gttttggccc ggccgggggc cgtgttatcg 15661 atgccttcat ccagctccgc ccccgcccgg attggtgccg tcgtgcgctg aaggcggtgt 15721 actcggtgcc atctgcgcca cgattgcgtc gatccaggta actgaagtgc tgaagctcct 15781 taccggagtc ggaactcccc tcgtcggtcg cctgctcatg tatgaagctc tcgacgcgac 15841 ataccatcaa atccggatcg cgaagaatcc tgactgcgcc atttgcggcg atgcgcccac 15901 gatcaccgaa ttggtagatg acagcgtcag ctgcgcatcg acacaatcgg tggatcccga 15961 actagtgatc agttgtgatg agttgcgaac caaacagcag tcggaccaga acttcctctt 16021 ggtcgacgtg cgagagcccg ccgagttcga catcgcgcac attccgggca gcatcttgat 16081 acccaaaggc gaaatcggct cggcggcggg cctagcccag ctaccgctgg acaaggaaat 16141 tgtcctgtac tgcaagagtg gaatccgatc ggcccaggcg ctaaccacgt tgaaagcagc 16201 cggactgcac aacgtgaagc atctcgacgg cggtatcgcg gagtggacac gaaccatcga 16261 ctcctccttg ttggtgtact agcaccgaac tatgcgaaag gattcccgcc atggcacgct 16321 gcgatgtcct ggtctccgcc gactgggctg agagcaatct gcacgcgccg aaggtcgttt 16381 tcgtcgaagt ggacgaggac accagtgcat atgaccgtga ccatattgcc ggcgcgatca 16441 agttggactg gcgcaccgac ctgcaggatc cggtcaaacg tgacttcgtc gacgcccagc 16501 aattctccaa gctgctgtcc gagcgtggca tcgccaacga ggacacggtg atcctgtacg 16561 gcggcaacaa caattggttc gccgcctacg cgtactggta tttcaagctc tacggccatg 16621 agaaggtcaa gttgctcgac ggcggccgca agaagtggga gctcgacgga cgcccgctgt 16681 ccagcgaccc ggtcagccgg ccggtgacct cctacaccgc ctccccgccg gataacacga 16741 ttcgggcatt ccgcgacgag gtcctggcgg ccatcaacgt caagaacctc atcgacgtgc 16801 gctctcccga cgagttctcc ggcaagatcc tggcccccgc gcacctgccg caggaacaaa 16861 gccagcggcc cggacacatt cctggtgcca tcaacgtgcc gtggagcagg gccgccaacg 16921 aggacggcac cttcaagtcc gatgaggagt tggccaagct ttacgccgac gccggcctag 16981 acaacagcaa ggaaacgatt gcctactgcc gaatcgggga acggtcctcg cacacctggt 17041 tcgtgttgcg ggaattactc ggacaccaaa acgtcaagaa ctacgacggc agttggacag 17101 aatacggctc cctggtgggc gccccgatcg agttgggaag ctgatatgtg ctctggaccc 17161 aagcaaggac tgacattgcc ggccagcgtc gacctggaaa aagaaacggt gatcaccggc 17221 cgcgtagtgg acggtgacgg ccaggccgtg ggcggcgcgt tcgtgcggct gctggactcc 17281 tccgacgagt tcaccgcgga ggtcgtcgcg tcggccaccg gcgatttccg gttcttcgcc 17341 gcgcccggat cctggacgct gcgcgcgctg tcggcggccg gcaacggcga cgcggtggtg 17401 cagccctcgg gcgcgggcat ccacgaggta gacgtcaaga tcacctgata gctaggaagg 17461 atgtctgaat ggccaatgtg gtagctgaag gtgcctaccc ttactgtcgg ctcactgatc 17521 agccgctgag tgtggacgaa gtgctagccg ccgtctcggg ccccgaacaa ggcggcattg 17581 tcatatttgt gggaaacgtg cgtgaccaca atgccgggca tgatgtcacg cggttgttct 17641 acgaggcgta tccgccgatg gtgattcgga cattgatgtc gatcatcgga cggtgtgaag 17701 acaaggccga gggtgtccgc gttgctgtcg cgcaccggac cggtgaattg caaatcggtg 17761 atgccgcggt cgttattggc gcgtcagctc cccaccgtgc ggaggcattt gacgccgcgc 17821 gtatgtgtat cgagttgctt aagcaggaag tgccgatttg gaagaaggaa ttcagctcga 17881 ccggtgctga atgggtcggc gatagaccat gagtccgtct ccatcggccc tgctcgccga 17941 ccacccggac cgcattcgtt ggaacgcgaa atacgagtgc gctgacccca cggaggcggt 18001 atttgcgccc atatcctggc tcggcgacgt gctgcagttc ggggtgccag aagggccggt 18061 tctggaactg gcgtgcggtc ggtccggcac cgcgctgggg ctagccgcgg cgggccgctg 18121 cgtgactgcg atcgacgttt ccgataccgc gttggttcag ctcgagctcg aagcgacccg 18181 acgggaattg gccgatcgcc tcacactggt gcacgccgat ctctgctcct ggcagtcggg 18241 ggatggacgc tttgctctgg tactttgccg actattctgg catccgccca cttttcgcca 18301 ggcttgcgag gctgtggcgc cgggcggtgt agtggcgtgg gaggcatggc ggcggcccat 18361 cgatgtcgct cgggataccc gtcgagccga atggtgcttg aagccaggcc agcccgagtc 18421 tgaacttccc gccggcttca cggtgattcg ggtggtcgac accgatggtt cagagccgtc 18481 gcggcgcatc atcgcccaac ggtcactgtg aacggtccct ggttgtatgc gcacgtcctt 18541 tgttgagaac ccgtttcgca ccgctccgat accgccagtc tgatgcaccg accgcgccgc 18601 ctcccacccg cggaagctaa cgaggtgtgc atgaaaccgg ggcggttcag cagcccggtt 18661 aattgacaat ctgtgaagag gttcccacga caatgggcac gttgggctcg cgatgtcgcg 18721 cgattcgagc gaggttgggt gacgttcccg tttgaggatc tcgccccagg gcgatgggtt 18781 ggcgggatgt cgatgtaccc ggaagagcaa aacgtggcat gcgataacga tccgagagga 18841 gtgcgatgac aagcacctcg attccgacgt tcccgttcga ccggccggtc ccgacggagc 18901 cgtccccaat gctgtcggaa ctgagaaaca gctgtccggt agccccgata gagttgccct 18961 cggggcacac agcatggctc gtcactcgct ttgacgatgt aaagggagtg ctgtccgaca 19021 agcgtttcag ctgcagggcg gcagcgcacc cgtcgtcgcc cccgttcgtg ccgttcgtgc 19081 agctttgccc cagcttgttg agcatcgatg ggccccaaca caccgcggcc cgccgtctgc 19141 tcgcgcaggg cctaaatccc ggcttcatcg cacgcatgcg gcccgttgtc caacagatcg 19201 tcgacaatgc gctcgacgat ctggcagccg cggaaccacc ggtggacttc caggaaatag 19261 taagtgtccc tatcggagaa cagctcatgg ccaagctact cggggtcgag cccaaaaccg 19321 tgcacgagct cgcggcgcac gtggatgcgg cgatgtccgt gtgtgagatc ggcgacgagg 19381 aggtgagccg gcggtggtca gcactgtgca cgatggtcat cgacatactg caccgcaagc 19441 tcgccgaacc gggtgatgac ctacttagca cgatcgccca ggcgaaccgg caacagtcca 19501 ccatgaccga cgagcaggtt gtcggcatgc tcctcaccgt cgtgatcgga ggagtcgaca 19561 caccgatcgc cgtgatcaca aacgggctgg cgagcctgct gcaccaccgc gatcaatatg 19621 aacggctcgt tgaagaccca ggccgtgtcg ctcgtgcggt tgaagaaata gtccggttta 19681 atccggcaac tgaaattgag cacttgcgag ttgtcaccga ggatgtcgtc attgccggaa 19741 ccgcgctatc ggcggggagc ccagcattta cctctatcac ttcggctaac cgcgactccg 19801 accaattcct ggaccccgat gagtttgatg tcgaacgtaa tccgaacgaa cacatagcat 19861 ttggatatgg tccacatgct tgcccggcct cagcgtattc acgcatgtgc ttgacgacgt 19921 tcttcacctc gcttacccag cgatttccgc aacttcaact cgcaagaccg tttgaggatt 19981 tggaacgacg gggtaagggc ctacattcgg tggggatcaa ggaactcctt gttacctggc 20041 cgacgtgacc ccgcgtgcca gcaagggact gttgacttct ccgacggatg aaagccgccc 20101 tggaatatcc aaccgctcct gctcctcggt caactcaagc cgaaaccgcc aacggtggcc 20161 acaaaatacg agttcgtcca caacgtcggc agccgggacc gcaaccacgc aaactcctca 20221 cgcactaccc gcaaccgacg gcccctaatt ggggttgggc ccatgatcgg ttggcggctc 20281 atcaggcggt gcaggatctt ggtgtgcccg cctcggcgcg gcggagccgg ggtcgagcat 20341 ctctttgcga gtgatgaagg cacagccccg gcgcggggtg ggtgtgcaac acgaatgtag 20401 gtagcgggag ttgaggctgg gcgcggtgta ttctggttgt tggataaaca accagaatgg 20461 ggagacgcgg gtgggcgagg actcgctgga ggatctggag cagcggcgag cgcgactgta 20521 tgaccagttg gccgcgaccg gcgatttccg gcgcggctcg atcagtgaga actatcgccg 20581 ctgcggcaag cccaattgtg tgtgcgcgca agagggtcac cccgggcatg ggccgcgata 20641 tttgtggacg cgcacggtgg ccgggcgggg taccaagggg cggcagctct cggtcgagga 20701 ggtggacaag gtgcgcgccg agttggccaa ctatcaccgt ttcgcgcagg tcagtgagca 20761 gatcgtggcg gtcaacgagg cgatctgcga ggcccgccca ccgaacccgg cggccacggc 20821 gcccccggcc ggcacaacgg ggcacaaaaa agggggctct gcgaccagat cgcggcggag 20881 ttcaccgccg aggtagagcg gctggttgcg ctcgcggtcg gtgcgctggg atcctcggtg 20941 ccgacctggt cgcagtggag ttggcgatcc gcactgcgat gacccggctg ggctcctcgc 21001 tgctggagca gctgctgggc gccgacaccg ggcaccgggg ccagcgcatc gattgcgggc 21061 aagggcattg cgcgtggttc gtcggttacc gcgacaagaa cctcgatacc gtgctggacc 21121 gggtccggtt gctccgcgcc tgctaccact gccgcacctg cgggcgtggg atggcgcccc 21181 ctggatctgg aacctggcca ccgcgatcct gcccgaagcc accccgatcg tggacctcta 21241 ccacgctcgc cagcacgtcc acgacctcgc cggccagctc gcacccgccc tcggcgaaca 21301 ccacagtgac tggctgaccg cccggctggt cgacctcgac tccggcgaca tcgaaacgct 21361 ggttcaacaa ccgatcgggc agcacaccgg tcacacgtaa cgaagtgtgc atgaaacccg 21421 gagtggttca ggggtccgcc gcgctcgtcc gcgctgtgag ggtctcggca ctaccacgag 21481 atgagatcga ggcaccaggt gcattgtgca ccacattctg gcgatgttgg tgaggtttgt 21541 tcctgcgccc gtccgtggcg cgttcgggat cgttggggtt ggccggttgc ccacctcggc 21601 ggaagcggac ggtgagcgcg gccgagtcgt cgacatttgg cggtaggagg tttcgatgct 21661 gtttgtcagc gtggccccgg agtcggtagg ggtggcggcg gcgactcttg ttgggccccc 21721 gttgatcggc aacggcgccg atcggccccc ggcaccggac aagccggcgg gatcttgtgg 21781 ggcaacggcc gttttcgccc aatcacagga gtggagtttt gaacgcaacg acggcaggtg 21841 ctgtgcaatt caacgtctta ggaccactgg aactaaacct ccggggcacc aaactgccat 21901 tgggaacgcc gaaacaacgt gccgtgctcg ccatgctgtt gctatcccgg aaccaagtcg 21961 tagcggccga cgcactggtc caggcaatct gggagaagtc gccacctgca cgagcccgac 22021 gcaccgtcca cacgtacatt tgcaaccttc gccggaccct gagcgatgca ggcgttgatt 22081 cgcgcaacat cttggttagt gagccgccgg gctatcgcct tctcattgga gatcgacagc 22141 aatgcgatct cgaccgtttc gtggcagcga aagaatcggg actgcgcgct tctgccaaag 22201 gatattttag cgaggcgatc cgttatctag attcggcctt gcagaattgg cgcggtccag 22261 tactggggga cctacgcagc tttatgtttg tccaaatgtt cagcagggcg ttgaccgaag 22321 atgagctcct cgtccatacg aagctggccg aagctgcaat cgcctgcgga cgcgccgacg 22381 tcgttatccc taaattggaa agactcgttg cgatgcatcc ttatcgcgag tcgttatgga 22441 agcagttaat gctcggctac tacgtgaacg aataccagtc cgcggcaatc gacgcatatc 22501 atagactcaa gtccacgctc gcagaggaac tcggtgttga gccggcaccc acgatacgtg 22561 cgctctacca caaaattctt cgccaattgc ccatggacga tctcgtcggc cgagtcacgc 22621 gtggcagggt tgacttgcgt ggcggcaacg gcgctaaggt agaggaactg accgagagcg 22681 ataaggatct ccttcccatc ggtttggcat aactacgccc ctcaatgcaa gcgagctgat 22741 tcgatgttgt cgagccggag cccgctccga cctccgtcac acagaccgga ctacgaatac 22801 tgacccgcgc tgctagccaa ccccggttcg tggaatcaca gtgagacgtg cctgcgtgac 22861 atgccaaccc gcaccatcac gatccatcag cccaccgggc ataccagcgc cggcaccgct 22921 aatactcatt ggcatcagca tcatcggcat accaccaccg gcggccccgg ccgcctgcgt 22981 cagcgcgact gggttaggcg gcacacccaa cccggacatc gctgaagaag ccatcgaaat 23041 gggtatcgac ccctgccacg tcggcggcac cgacatcgac cccaccaact gagcctgccc 23101 taagccagcg gacatccccg cacccaattc ccgaccgcct agcggcttga acgccggaat 23161 agccgcacca ctcgggttcg gcgtattcgc ggcagccaac ccgccagccg gcggacctaa 23221 cctggtcgcg ctttcacgcg ccatactcgc caacgtcgtt atcggcgacg tcaggatgcg 23281 gaccgggaga aacaacatcg acgcatgttg caacggcagc tgcgacacca gcgactgcat 23341 cccgctcatc acggtcggca ccgacgccat cgcaccctcg accaccggcg tcacggcagc 23401 cgacgccgtc gtcgccatcc cggcaacctg ggtacccacc tgcgcggcca acccggctaa 23461 gctcaccggc ggcagactaa atggcgccaa cgtcgccgcc acggactttg ccccagcgtg 23521 atagcccacc atcgcagcca catcctgagc ccacatctcc aggtaatcga actccgtggc 23581 tgcgatcgcc ggggtgttct gacccaaaac gttcgccgct atcaacgacg ccagcgacac 23641 ccgattcgcc gtcaccgccg tcggatgcac cgtggccgcc aacgcggcct caaacgccgt 23701 cgctgccgcg cgagcctgaa tggccgccag ctgcgcctgc gacgccaccg tgctcaacca 23761 cccgacatac ggagacgcgg cagcagccat cgacatcgac gccggaccgg tccacggccc 23821 agtcgtcaac gcggcgagca ccgactcaaa cgacgatgcc gatgcccaca aatccgcggc 23881 tagcccctcc cacgccgagg ccgccgcaaa caacggcccc gagccggctc cggcaaacat 23941 gcgcgccgag ttgatctccg gcggcagcca cgaaaagccc aaaaccatcg caaccccagc 24001 ccaatcagcc gcccagaagg gtctcgtaca agggttaact aaacaatcgt taccgaatga 24061 atcgacacat cgtgacgcac cgatggctca gcacgccgga cttctagaac aacgagcaca 24121 acggatatga tgcggcaggc atcttcatgg attgtcaatg acagcccaaa ccgccttcgg 24181 ccactggcat tggtgcactg caccgtgcgc cattcgtggc gacaactgcg agcgggagcg 24241 ggaccaagga tgatggtccc ggtcgcgacg ggcgcgatcc cgctccggag tggtcaacgc 24301 atcaaacgac aaagcgctca gctcatcgac cgcagcatcg agccggtcca gcgccgcgac 24361 caaactagaa ttctcgcgca gacaccgctg aaacgacagt gacgcaaggg atttcattga 24421 gaggaccaat gaccctattt gatcaaaccg gatgaccata ccgtcaacgt tgtggacata 24481 caggtgctca agaacgcagt cttgctggca tgccgggcgc cgtcggtgca caacagccag 24541 ccctggcgtt gggtggccga aagcggctcc gagcacacta ctgtgcacct gttcgtcaac 24601 cgccaccgaa cggtgccggc caccgaccat tccggccggc aagcgatcat cagttgcggt 24661 gccgtactcg atcaccttcg catcgccatg acggccgcgc actggcaggc gaatatcact 24721 cgctttcccc agccgaacca acctgaccag ttggccaccg tcgaattcag tcccatcgat 24781 cacgtcacgg cgggacagcg aaaccgcgcc caggcgattc tgcagcgccg aaccgatcgg 24841 cttccgtttg acagcccgat gtactggcac ctgtttgagc ccgcgctgcg cgacgccgtc 24901 gacaaagacg ttgcgatgct tgatgtggta tccgacgacc agcgaacacg actggtggta 24961 gcgtcacaac tcagcgaagt cctgcggcgg gacgatccgt actatcacgc cgaactcgaa 25021 tggtggactt caccgttcgt gctggcccat ggtgtgccgc cggatacgct ggcatcagac 25081 gccgaacgct tgcgggttga cctgggccgt gacttcccgg tccggagcta ccagaatcgc 25141 cgtgccgagc tagctgatga ccgatcgaaa gtccttgtgc tgtcgacccc tagcgacacg 25201 cgagccgacg cactgaggtg tggcgaagtg ctgtcgacca tcctactcga gtgcaccatg 25261 gccggcatgg ctacctgcac gttgacccat ctgatcgaat ccagtgacag tcgtgacatc 25321 gtgcggggcc tgacgaggca gcgaggcgag ccgcaagcct tgatccgggt agggatagcc 25381 ccgccgttgg cagcagttcc cgcccccaca ccacggcggc cgctggacag cgtcttgcag 25441 attcgccaga cgcccgagaa agggcgtaat gcctcagata gaaatgcccg tgaaacgggt 25501 tggttcagcc cgccttgatc aggatgcctt tgtggatgtc gggtagggcg gtggggatgt 25561 tagcgaggta gagctgctcg gttttctcct tggccaagat gaggagtcgg ttctgcaggt 25621 cggcgatttt gcggccgatc tgggcggggt tgaggctgtc tcggtaggtg atcaggtcgg 25681 cctgctgggc cgcggagagc acccttgcgg ccagtggccg gtccagcggc gtctgtgggg 25741 catcgtagag gcgtcggcgg cggccgtcgg cgctgctggc atacccgatc ggtttgatgg 25801 tcggggtgag gtagttgagg cggtcgttga ccagcttcca catccggttg agcacggcgc 25861 gttcctcggc ggtgtcatag cggtagtaga acgcgtactt gcggaccagg tggttgttct 25921 tggactcgat ggtggcctag tggtttttct tgtacgggcg aaagcgggtg aagtagatac 25981 cgttgtcgcc ggcccagctg atgaccggct tgttgagaaa cacggtgccg ttgtcgaaat 26041 ctaaacccgt tatcccatgc gggatctcgg tgacagaagc tttgagcccg gcgaggatgt 26101 gggtacgggc gttgttgcgg acggtgcggg tgaacaccca tccgatgtgc acgtcggtca 26161 agttcagggt gtgggcgaac tcgcctttga gcgtcggacc gcaatgggcg acggtgtcgc 26221 cctcgaagaa ccccggctcc gcctcgacct catcgccggc cctgcgaacc ttgatcgaat 26281 tacgcagcag tggtgagggt ttcgtcgtcg acacacccga tatctggtct ttggccttcg 26341 cggtcttcag ataacgatcg atgctggccg cactcatcgc caacagctcc tcacgcacct 26401 cggggccata gcggtcacgc ccaaactcca acacaccgtg acgttccaac ccatcaagct 26461 gcagcaccat cgaggcggca agatacttcc cgcactgccc acccgaggcg gaccacaccc 26521 tctgcaacac cttcagcgcg tcataggagt acttcagcga acgcggtttg cgccgccgct 26581 tggcaacact gcggcccagc cccggcgata gcttggccgc tgcgacaagc cggcgccgcg 26641 cgttatcacg tgactagccc gtcaggtcaa ccacctggtc gaaaatccgg ccccggctct 26701 tcttcaaagc ctgcacatac gccttggcgt acctgctggt gacctccgcg cgagatctca 26761 tcgacaaccc acttcccatg cctcacgacg gtcaccatgt cgcgggcata tttacgtgag 26821 gcaccgaggg tgtttcgcgg gcattcttgg tgagtcaagt cgaacggttg agccatgatc 26881 gacgattccg ttaccgtgct gtcagaagac gaaagttggc accggctggg cagcgttgca 26941 ctcggtcggc tagttaccac ctttgctgat gagcctggga tcttccagtc aatttcgtgg 27001 tgcaaggccg caccgtgctg tttcgtaccg cggagggcgc caaattattt tcagccgtcg 27061 cgaagtgcgc ggtggctttc gaggcggacg accacaacgt tgccgagggc tggagcgtga 27121 tcgtcaaggt tcgcgcccag gtgctgacga ccgacgcggg ggtccgcgaa gccgaacgcg 27181 cccagttact accgtggacc gcgacgctga aacgtcactg tgtgcgggtg atcccgtggg 27241 agatcaccgg ccgccacttc aggttcggtc cggaaccgga ccgcagccag acctttgcct 27301 gcgaggcctc gtcacacaac cagcgatagc gctccgcgcc tgcgagtcac cttgcgccgc 27361 ttactgatcg ccaccagccg tgcgacggcg tcttcaattc ctcgcgccag ctggccggca 27421 tctgctacca cgtcgtagtc ggccaggatc ccgaagtaca ggtcgtcggc gtagctgagc 27481 atcgcgacac tggtgcgcag ttgcatcgcg atcggcgaaa ccgggtatag gtcaagcacc 27541 cgtctgccca taatctgcag cggccgtcgt ggacccggca catttgtcgc cacggtgaca 27601 acaccacgct gcggcagccg catcaacagc ccgaccgccc atgcggtcat ggggaacgga 27661 aggcggttgg caatcgccat caaagtattt ccgaattgtc tctgtccccc cgccttggcc 27721 cgagtcagcc gcgagtgcac gatccgcagc cgctgcagcg ggttctcttg atccaccggc 27781 aggttgggca gcattaacga aacacggtta tcggtcttgc tcaaagcgct gttggaacgc 27841 gtcgagaccg gcactagcgt acgcagcgaa tcaaacctag gccgctcacc ccgctggatg 27901 aggacgttgc ggtagctttc cgtaatcgcg gcaagcgcaa catcattgat ggtgacgtcg 27961 aatttccggc acacctgttc gacgtcggcg agagggacct ttgctgcgct gtagcgacgc 28021 aaatcactga tcggcccgtt caacgacgac gcggcgggac ttagcacgcc ggccgcgatc 28081 tcactggcac ccttggccgc gcgaacgatg cctgccatca cggcggtcga cgcggtcaac 28141 gcctcgcttg gattgacacg gaatccaccc cgccgcacag atgcggattg cgactgcatg 28201 gtcgtgtgga tgttgctcgc gaagctgtcg ctcatacttt catcggagag cccagctagc 28261 aggtgagtcg ccgcgattcc gtcggccatg cagtggtgca gtttggtcag gatcgcccac 28321 ttgctgtccg ccaggccttc gatgacccag acctcccaca gcggtcgacc ccggtccaaa 28381 cgacgcgcca tcagatcggc gatcagctcg aataactggt cttcgttgcc aggccgcggc 28441 aaggcgatgc gccacacatg acggccaaga tcgaagtcgg gatcgtccac ccatttgggt 28501 gcaccgaggt cgaacgggcg caggcgtaac cgctgcccga accgggtaca gggacgtagg 28561 cgttgagcga gcgacgataa gaaggcttcc tgatcgggag ccggcccctc gatgaccgcc 28621 agagcgccga ttgccagact cacgtgccga tccacgtctt ctgccttgag aaacccggcg 28681 tcaagtgtcg ttaggtgatt catggtcagc gccttccccg gtgatccgga ttatctgcaa 28741 ccgtcagtac cactctccgc tgcgaggagc cgttgaggca gggccaaagg tcctccgctg 28801 gcgagccttc gtgctctgcc accgcggctg tcgacgcgcg atccttaata gatgaccgca 28861 gccgttgatg ggaaaggccc ggcagccatg aacacccatt tcccggacgc cgaaaccgtg 28921 cgaacggttc tcaccctggc cgtccgggcc ccctccatcc acaacacgca gccgtggcgg 28981 tggcgggtat gcccgacgag tctggagctg ttctctagac ccgatatgca gctgcgtagc 29041 accgatccgg acgggcgtga gttgatcctc agctgtggtg tggcattgca ccactgcgtc 29101 gtcgctttgg cgtcgctggg ctggcaggcc aaggtaaacc gtttccccga tcccaaggac 29161 cgctgccatc tggccaccat cggggtacaa ccgcttgttc ccgatcaggc cgatgtcgcc 29221 ttggcggcgg ccataccgcg gcgacgcacc gatcggcgcg cctacagttg ctggccggtg 29281 ccaggaggtg acatcgcgtt gatggccgca agagcagccc gtggcggggt catgctgcgg 29341 caggtcagtg ccctagaccg aatgaaagcc attgtggcgc aggctgtctt ggaccacgtg 29401 accgacgagg aatatctgcg cgagctcacc atttggagtg ggcgctacgg ttcagtggcc 29461 ggggttcccg cccgcaacga gccgccatca gaccccagtg ccccgatccc cggtcgcctg 29521 ttcgccgggc ccggtctgtc tcagccgtcc gacgtcttac ccgctgacga cggcgccgcg 29581 atcctggcac taggcaccga gacagacgac cggttggccc ggctgcgcgc cggcgaggcc 29641 gccagcatcg tcttgttgac cgcgacggca atggggctgg cgtgctgccc gatcaccgaa 29701 ccgctggaga tcgccaagac ccgcgacgcg gtccgtgccg aggtgttcgg cgccggcggc 29761 tacccccaga tgctgctgcg agtgggttgg gcaccgatca atgccgaccc gttgccaccg 29821 acgccacggc gcgaactgtc ccaggtcgtt gagtggccgg aagagctact gcgacaacgg 29881 tgctgaccat cgcagcactg ttccgctcgc gcccggtacg ctcgcgaggg tgaattcgcc 29941 gccggcctgc tctgcccgct gccgcaggtt cgttaagccg cttccggtga actcgtcggg 30001 cagcccgcgg ccgttgtcgg tcacctcgat gcacaagtcg tcgtcgactt tgacccggac 30061 ggtcaacgtg ctggccttcg catggcgaac cgcgttgctg accgcttccc gaaccaccgc 30121 ctcggcctga tcggcgagcg cgctgtcgac caccgacaat ggacccacga attgaacgct 30181 ggtgcgcaac cccgagtcgg caaattgggc tacggccgca tcgattcgct gccggagccg 30241 agtgataccc tgcgatgctc cgtgcaggtc ataaatggtg gtccggattt cctgtataac 30301 gtcttgcaga tcgtctacca cgtccgagag tcgttgctgc acttcaggat tacgttcgtg 30361 cgggacagca ccctgcaaag ccaggccaat cgcgaagagc cgctggatga catggtcatg 30421 gaggtcacgg gcgatacgat cccggtcggt cagtacgtcg agttcgcgca tccgacgttg 30481 cgaagtggcc aattgccaag ccagcgcggc ctggtcggcg aacgcggcca tcatctcgag 30541 ttgttcgtcg gtgaaagccc ctggaccgcc ttgactcagc acaacaacga cacccgctac 30601 ggtacctctg gcccgcagcg gcaacagcag cgccggacct gcgtcggcca gttcgtccag 30661 gccttccaaa tcgacccggt cgacccgtcg cggaatgccg ttgacgaaga cctcccgcag 30721 caccgcgccc gccaccggaa tcgttcgccc aacaatggaa gccacagcgc tgccgactgt 30781 ttcaatcacc agcagctccc ccacgtcagc ggcaggcatg tcctcgtcga cgggaacggc 30841 taccagggca gcgtcagccg ccgtcagctt gagcgcctcc gcggcgacaa gccggaacac 30901 cgtcgcgggt tcggtgccgg acaacaactc ggtggcgatg tcacgggtgg cctcgatcca 30961 cgactgacgc gccttagcct gctggtagag ccgggcattc gcgactgcga tacccgcggc 31021 ggccgccagc gcctggacca gaacctcgtc gtcgtcgctg aacggttgcc cgttggtctt 31081 gtcagtcagg tacagagtgc cgaacgattc atcgcgcacc cgaaccggta ccccgaggaa 31141 ggtacgcatc ggcggatgat acggcggaaa accaatcgag gccgggtgcg cagaaacatc 31201 gtccagccgt aacggtttgg gatcttcgat gagcagcccg atgacgccta ggcctttcgg 31261 taggtggccg atccgccgaa cggtctcctc gtcgatgcct tcatagacaa agtgcaatac 31321 ccgatgctgc cggtcgtgca cctccatagc gccatagcgc gcatcgacaa ggctggtcgc 31381 tgaatgcacg atagcgcgta gggttgcctc caggtccagg cccgctgtga ccacgagcat 31441 ggcctccacc agaccatcga ggcggtcccg gccctcgacg atctgctcga cccggtcctg 31501 cacctcgacc agcagctcgt gcaggcgtag ttgggagagc gtgtgacgca gtggacgcat 31561 tgcggcgccg tcgttttcgt cgacgaggcc ccctgttgtc atggtccatc accgggtggc 31621 cgcgagcgct tcaactccgt cgcgaatacc gcggcttgcg tccgacgttc catgcccagc 31681 ttggccagca accgcgacac gtagttcttc accgtctttt cggctaggaa cattcggtcg 31741 gcgatctgct tgttggtcag gccctcgcta agcaggccca gtagcgtccg ctcctggtcg 31801 gtaaggcctg atagcgggtc ctgcttctcg gcggcaccgc gcagcttggc catcagcgcg 31861 gccgcggccc gattgtccag cagcgaccgt ccagcgccca catctttgac ggcgcgcgcc 31921 aactccattc ccttgatgtc tttgacgaca tatccgctgg caccggcgag aatcgcatct 31981 agcatggcct cgtcagaggt gtaggacgtg aggatcagac agcgcagatc gggcatgcgg 32041 gacaacagat cgcggcacag ttcaatgccg ttgccatcgg gcaaccggac atccagcacc 32101 gcgacatctg ggcgcgcggc aggaaccctg gccatcgcct cggcgaccga acccgcctca 32161 cctacgacgt caagctcggg atcggcccca agcaagtcaa ccagaccacg acgcaccacc 32221 tcgtggtcat cgaccaagaa gacctttacc accagggcac cactcccaag atccgctccc 32281 tacaagttgg cactgcgtac cgtaagtacg gcgcatccgg gctggtatgc accgcacaat 32341 tcgtgcgcgg agtgtgagtc cgcgacgaac agctgacccg gctttgcgtt ggcggccaga 32401 tgacggcacg cactgccgcc ggcgatggcc cgatccaccc gcacctcggg gtagagccgg 32461 gtccagtggg cgagccgacg gctcaggtgt acatgcgcca accggctgcc ctgttcgacg 32521 tcatcgggtg tttcagcagc gtggacagcc acggcccgca gcggaactcc gcgcagcctg 32581 gcctcctcga atgcgtgccg cagcaccaca ccattgtcca cctccgcgac aaccgcgctg 32641 acctgggagg ttgtcgctgg ctcggccggc gacgggtgaa tcaccgccac ggggcataag 32701 gccgacccag ccagggtcgc cgcgaccgaa ccccggcgac cgcggacatg atcaagcccc 32761 accgaaccga cgcacagcat cgccgcggac ctggactcct gcatcagctt ggtgagcggc 32821 ctgccgcaca gaacctccgt ttcgatcttg accggttgcc cggtggcctc gaccttccga 32881 gaggcgtcgt gcagcgccgc tcgggccgct gattgcccac cgccctcgcc ggcggcggac 32941 agttgggacg gatcgatgac gtacaccagt cgcagcggaa tgtctcggtt caccgcctca 33001 tcgaccgccc acaacgccgc atgcgttgcc gcccttgacc cgtcgatacc aacgaccact 33061 gcccgagctg gccgaggatc gctcatcgcc gtctccttcg ctggggcgga tacatcccgt 33121 cggttcagcg gtacgttact ggcggggacc gctatctccc aggggcgttg gtccccacct 33181 gagggccgtt agtccttatc gaccgatgac agacgcaacc cgtcagggcg agaatgaatc 33241 tcacctatcg cacgggtggc tcgtccaggt ccacaaccat cgcccagctt ttcacagcaa 33301 agtcccagaa atggcttaca gttgccgaca gctgccgaac cagcggccgt ccatcggctg 33361 catatcgctt gacccacaga atatttgggc atagccgcgc tgtgagagcg catctcgatg 33421 cggccggcac ggcgtcgatc aatctccgat ccgccgtcag tcgactgcca tacaacctgc 33481 ccgcccagtt gtacactggc cgcggcacga gttgccgcac tggtcaacaa gtatcagccg 33541 gcctgcgccc gagcggagcc cactcggagc cgctcgtgac catgggggga gccactgccg 33601 tctcccgcat gcccacaccg aggtccgaat tgggctgggt gcgcaatcga cgttaggggc 33661 ctgcggagta atggactacg cgttcttacc accggagatc aactccgcgc gtatgtacag 33721 cggtcccgga ccgaattcaa tgttggttgc cgcggccagc tgggatgcgc tggccgcgga 33781 gttagcatcc gcagcagaga actacggctc ggtgattgcg cgtctgaccg gtatgcactg 33841 gtggggcccg gcgtccacgt cgatgctggc catgtcggct ccatacgtgg aatggctgga 33901 gcggaccgcc gcgcagacca agcagaccgc tacccaagcc agagcggcgg cggcggcatt 33961 cgagcaggct catgcgatga cggtgccccc agcgttggtc acaggcatcc ggggtgccat 34021 cgtcgtcgaa acggccagtg ccagcaacac cgctggcact ccaccttgac ccattcagtt 34081 ctcgaccagc acgacaccgt atccgcacaa atgtaaggag ctgagacaca atggatttcg 34141 cactgttacc accggaagtc aactccgccc ggatgtacac cggccctggg gcaggatcgc 34201 tgttggctgc cgcgggcggc tgggattcgc tggccgccga gttggccacc acagccgagg 34261 catatggatc ggtgctgtcc ggactggccg ccttgcattg gcgtggaccg gcagcggaat 34321 cgatggcggt gacggccgct ccctatatcg gttggctgta cacgaccgcc gaaaagacac 34381 agcaaacagc gatccaagcc agggcggcag cgctggcctt cgagcaagca tacgcaatga 34441 ccctgccgcc accggtggta gcggccaacc ggatacagct gctagcactg atcgcgacga 34501 acttcttcgg ccagaacact gcggcgatcg cggccaccga ggcacagtac gccgagatgt 34561 gggcccagga cgccgccgcg atgtacggtt acgccaccgc ctcagcggct gcggccctgc 34621 tgacaccgtt ctccccgccg cggcagacca ccaacccggc cggcctgacc gctcaggccg 34681 ccgcggtcag ccaggccacc gacccactgt cgctgctgat tgagacggtg acccaagcgc 34741 tgcaagcgct gacgattccg agcttcatcc ctgaggactt caccttcctt gacgccatat 34801 tcgctggata tgccacggta ggtgtgacgc aggatgtcga gtcctttgtt gccgggacca 34861 tcggggccga gagcaaccta ggccttttga acgtcggcga cgagaatccc gcggaggtga 34921 caccgggcga ctttgggatc ggcgagttgg tttccgcgac cagtcccggc ggtggggtgt 34981 ctgcgtcggg tgccggcggt gcggcgagcg tcggcaacac ggtgctcgcg agtgtcggcc 35041 gggcaaactc gattgggcaa ctatcggtcc caccgagctg ggccgcgccc tcgacgcgcc 35101 ctgtctcggc attgtcgccc gccggcctga ccacactccc ggggaccgac gtggccgagc 35161 acgggatgcc aggtgtaccg ggggtgccag tggcagcagg gcgagcctcc ggcgtcctac 35221 ctcgatacgg ggttcggctc acggtgatgg cccacccacc cgcggcaggg taacccggcg 35281 cctaaccgac aggcggcccg ttgggcgtaa acgtccaatt gtcaggattc ttcggcgagt 35341 acaccaccgg aagtatttga ccgacggtcg gccactggtc gacgtcgacg gccatgcgct 35401 gatacacggc gtactcattg accgtgggcc cagtgatgat cccggcgatg gtgacatact 35461 gctggccgcc tgcgtccggt cgcgggctga ctccggtcac caggagcgtg ccgctggcca 35521 gatctccccg cgggccgcgc gggataagcc gcggagcaag aaataccgct aggaccgcga 35581 tcagtatgag tagcacgcca aactcccatc ccacccggcc atggtaggac tgctggcatg 35641 agccgttatt acgccgagcg tgaactcagt gcaagaacgc acgcgaaaaa tcgcactggg 35701 tacacgctcg gcgaaaggat ggtgcaccag tgagccacga cgatctaatg cttgcgctgg 35761 ctctggccga ccgtgcggac gaattgacgc gggtccggtt cggggcgctc gatctgcgca 35821 tcgacaccaa accggatttg acgccggtga ccgacgccga tcgggcggtc gaatccgacg 35881 tgcgccagac gctgggccgc gaccggcccg gcgacggcgt cttgggcgag gagttcggcg 35941 gatcaacgac cttcaccgga cggcagtgga tcgtagaccc gatcgacggc accaaaaact 36001 ttgtgcgcgg ggtgccggtg tgggccagtt tgatcgcgct gcttgaagat ggcgtcccgt 36061 cggtcggtgt ggtgagtgcg ccggcgctgc aacggcggtg gtgggcggca cgcggccggg 36121 gcgcgttcgc atccgtcgat ggtgcgcgtc cacaccggct gtcggtttcc tctgtggcag 36181 agctgcattc ggcgagcttg tcgttttcca gtctgtccgg gtgggcgcgg ccgggtctac 36241 gtgaacgctt catcgggttg accgataccg tgtggcgcgt gcgtgcttac ggcgactttc 36301 tgtcttactg cctggtggcc gagggcgccg tcgatattgc cgccgaaccg caagtgtcgg 36361 tatgggatct ggcggcactg gacatcgtgg tgcgtgaggc gggcgggcgg ctcaccagcc 36421 tggacggcgt cgccggccca cacgggggca gcgccgttgc aaccaacggt ctgttgcacg 36481 acgaggtgct gacacggctc aacgccgggt aacctggcgc tcgagagcgc catgagcgac 36541 ccgttcacca tcgcaaccaa acactggcac cgactgcacg acagccggat ccagtgcgat 36601 gtatgtccac gcgcatgcaa acttcacgag ggacagcgtg gcctgtgttt cgtccgcggc 36661 cgatttgacg atcaagtgaa gctcaccagc tacggacgct ctagcggatt ctgtgtcgat 36721 ccgatcgaga aaaagccgct caaccacttc ttgccaggtt cggcgacgct gtctttcggc 36781 accgccgggt gcaacctggc gtgcaagttc tgccagaact gggatatctc caagtcccgc 36841 gagatcgacg tcctggccag tcgggcggcc ccggccgaca tcgcccggac cgcacacgaa 36901 ttgggttgcc gcagcgtggc attcacctac aacgacccaa cgatcttctg ggagtatgcc 36961 gccgatgtag ccgacgcctg ccacgaccag ggaatcaaag ccgtcgcggt gacggccggg 37021 tacatgtgtc ctgagccccg cgcggaattc taccggcgtg tcgacgccgc caacgtcgac 37081 ctaaaggcat tcaccgaaga cttttatcgc aaggtttgcg tcagtcacct gcgcaacgtc 37141 ctggacaccc tggcctacct gcggcaccag acgaatgtgt ggttggagat caccaccctg 37201 ctgattcccg gacgtaacga cagcgacgcg gaagtcgctg ccgaatgcag atggatccgc 37261 gaaaacctgg gcgtcgacgt gccggtgcat ttcaccgcgt tccatcccga ctacaagatg 37321 atggacaccc cggctacacc aaccgccaca ttgacccgag cccgcgagat cggcattggc 37381 gaaggcctgc gcttcgtcta caccggaaac gttcacgatg ccgtgggtgg cagcacctcg 37441 tgcccaggct gccgggcaac ggtgatcgtt cgcgactggt attcgatacg acattacgcc 37501 ctcaccgagg acggccgctg ccaagcatgc ggctatcaga tgcctggcgt gtacgacgga 37561 ccggccggac actggggcca gcgccggctg cccttgctga ccagcttgtc ccggatgtga 37621 acaacttaac aagcacccct atcttactcc ggagtaagat agggtggtcc gctatcaccc 37681 cgatgaccga ggctgccgta tgaccaacac cacctctgct gcaaatgctg caaaaccctc 37741 cggcgcacgc accgatagac gcggccgcac gaccggtgtc ggcctggcgc cccacaaacg 37801 gaccggcatc gacgtcgcac tggcgctgct aaccccgatt gtcggccagg agttcctgga 37861 caaataccgc ctgcgcgatc cgctgaaccg atcactgcgc tacggcgtga agacgatgtt 37921 tgccactgcc ggcgccgcca cccgtcagtt ccagcgggtg caaggcctgc ggggcggacc 37981 gacccggctg aagtccagcg gccgagacta cttcgatctg acgcccgatg acgaccagaa 38041 gctgatcatc gagaccgtcg acgaattcgc cgaagaggta ctgcgacccg ccgcgcacga 38101 cgccgacgac gccgcgacct acccgtccga cttgaccgcc aaggccgccg agctgggcat 38161 taccgcgatc aacatccccg aggacttcga cggtatcgcc gaacaccgct ccagcgtcac 38221 caacgtgctg gtggctgagg cactggcgta tggcgacatg ggcctggcac tgccgatcct 38281 ggcgcctggc ggggtggcgt ccgcgctcac ccattggggc agcgccgatc agcaggccac 38341 ctatctcaaa gagttcgccg gcgagaacgt tccgcaggcc tgcgtggcca tcaccgaacc 38401 gcagccacta ttcgatccca cccggctgaa gaccaccgcg gtgcgcaccc cgtccggtta 38461 ccggctcgac ggcgtgaagt cgttgatccc ggccgccgcc gacgccgagc tgtttattgt 38521 cggcgcgcag ctgggcggca agcccgcact gttcattgtc gagtccgcgg ccagcggcct 38581 gaccgtcaag gcggatccga gcatggggat tcgcggcgcg gcgttgggcc aggtcgaact 38641 ctgcggggtg tcggtcccgc ttaacgcccg gctgggcgag gacgaagcca gcgacaacga 38701 ctattccgag gcgcttgcgc tggcccggtt gggttgggcg gcgctggcgg tcggtacctc 38761 tcacgccgtg ctcgactacg tcgtcccgta tgtgaaacaa cgccaggctt tcggcgagcc 38821 gatcgctcat cgccaagcgg tggcgttcat gtgcgccaac atcgcgatcg agctcgacgg 38881 cctgcgcctg atcacctggc gcggggcgtc ccgtgccgag cagggtctgc cgttcgcaag 38941 ggaagcggcg ctagccaagc ggcttggctc cgacaagggc atgcagatcg gcctggacgg 39001 ggtgcaactg ctgggcggcc acggctacac caaggagcat ccggttgagc gctggtaccg 39061 cgacctgcga gccatcggcg tcgccgaggg cgttgttgtc atctagaacg agctgaaaga 39121 tcaatcatgg caataaatct ggaactgccg cgcaagctgc aggcgatcat cgtcaagacc 39181 catcagggcg ctgcggagat gatgcggccg atagcccgca agtacgacct gaaggaacat 39241 gcctacccgg tcgaactcga caccctgatc aatttgttcg agggcgccgc cgaatcgttc 39301 aactttgccg gagcccattc gcttcgcgac gaggacgaag gcaaggacga aaaccacaac 39361 ggtgccaaca tggccgccgt ggtacagacg atggaggcca gctggggcga cgtcgcgatg 39421 atgctgtcgc tgccctatca ggggctgggt aacgcagcca tctccgcggt agccaccgac 39481 gagcagctgg agcggctggg caaagtgtgg gcagcgatgg ccatcaccga accggaattc 39541 ggatcggact cggcggcagt gtcgacgacc gccaccctcg acggcgacga gtacgtgatc 39601 aacggcgaga agatctttgt caccgccggt tcccgcgcca cccacatcgt ggtctgggcc 39661 acgctggaca aatccttggg ccgcccggcg attaagtcgt tcatcgtgcc ccgtgagcat 39721 cccggcgtga ccgtcgaacg acttgaacac aaactcggca tcaagggttc tgatactgcg 39781 gtgatccggt tcgacaacgc ccgtatcccc aagggcaacc tacttgggaa cccggaaatc 39841 gaggtcggca agggctttgc cggggtgatg gagaccttcg acaacacccg gccgattgtg 39901 gccgccatgg ccgtcgggat cggccgtgcc gcactggagg aaatccgtag tgtcctcacc 39961 ggggccggcg tggagatctc ctacgacaag ccctcacaca cccagagcgc cgcggccgcc 40021 gagttcctgc ggatggaggc cgactgggag gccagctacc tactgtccct gcgcgcagcc 40081 tggcaggccg acaacaacat ccccaactcc aaagaagcct cgatgagcaa ggccaaggcg 40141 ggccggatgg ccagcgacgt cacctgcaaa accgtcgaat tggcaggaac taccgggtat 40201 tccgagcaat cactgctgga gaagtgggcc cgcgactcca agatcctgga catcttcgag 40261 ggcacccagc agatccagca gctggtggtc gcacgccgac tgttgggcct gtcgtcgtcc 40321 gagctcaaat agcctcggcg agcagacgtc aaagcccccg aatttcagtg aaatcggggg 40381 cttttgcgtc tgctggcgcc cgtctgcacc cccgccagta ggctggtcgg catgcgcgcg 40441 gtacgggtga ctcggctgga gggaccagat gcggtcgagg tggccgaggt cgaggaaccc 40501 acgagcgccg gtgtggtcat cgaggtgcac gctgccggcg tggccttccc ggacgcactg 40561 ctaacccgtg gccgttacca gtaccgcccg gagccgccat tcgtgctcgg cgccgagatc 40621 gccggagtgg ttcgatcggc gccggataac agccaagtgc gttccggaga cagggttgtc 40681 ggcctcacga tgctcaccgg cggcatggcc gaagtcgcgg tattgtcgcc cgagcgcgtg 40741 ttcaagctgc cggacaacat gactttcgag gcgggcgcgg gcgtgctgtt caacgacctg 40801 acggtgtact tcgcgctggc ggtccggggc cggctgcagg ccggtgagac ggtgctggtg 40861 cacggggcgg caggcgggat cggcacatcg acgttgcgac tagcgccggc gctcggggcg 40921 tctcgcaccg tcgcggtggt cagcacgcag gagaaggccg agcttgcgac agtggccggg 40981 gcgacagatg tggtgttggc cgaggggttc aaggacgcgg tacaggagct gacgaacggc 41041 cgtggtgtcg acatcgtcgt agacccggtc ggcggcgacc ggttcaccga ttcgctgcgc 41101 tcgcttgctg cgggaggacg gctgttggtc atcggcttca ctggcggcga gattcccacc 41161 gtgaaggtaa accgccttct gctcaacaac attgacgttg tcggggtagg ctggggcgcc 41221 tggtcgctga cccaccccga tgcgctggcc cagcagtggt cacaactcga gcggctgcta 41281 cgctcgggca agctgcctcc tcccgaacca gtggtctacc cactggacca agccgctgcg 41341 gcgattgcat cgctggagaa tcgcaccgcc aaggggaagg tcgtactacg cgtgcgcgac 41401 taacgcccct cccgggacgc gtcgccggcg tgctctggcc aatttgccgc ttcctcactg 41461 gtcgccgttg gcgtcggcta cgtcatgccg cacaactcgc agcttgcctg gcgccaggca 41521 cgcggcgtat ccgtggtatt tgccatacag ttcccatgcg gtgacgcgat catcggggtg 41581 cacgtcgatc tgatgaccgt cggagaactc aagatggaga tctccggtgt cataccagac 41641 gaaagctgtg caggttgccc cggcgaaatc gaagagcgga cgctcgtggt cggctgggtc 41701 gtttgggtcg atggcgacca cttctgcggg cgaggtttcg atggccggca gagtcagctg 41761 tagtggtacc gagatgacca gctcgttgta atcgtcgaag ttcagcacca gaccgtcgcg 41821 gaacataatc cgctgaaccg cacagccctc taaccactgc tcggtcattt cctgttcggt 41881 catatattca ctctggcctt gttgtgccca tatgtcacgt acacaaccgc cgaaatctcg 41941 tgcgggatta caccctaggc gtccgatgga caccagtacc atctgacacc gtgcccgact 42001 ccagcaccgc attgcggatc ctcgtctaca gcgacaacgt ccagacccgc gaacgggtga 42061 tgcgggccct gggcaaacgg ttgcacccgg atctgcccga tttgacctac gtcgaagtgg 42121 ctaccggtcc gatggtgata cgccagatgg atcggggggg catcgacttg gccatcctcg 42181 acggtgaggc gacaccgacc ggaggcatgg gaatcgccaa acagctcaaa gacgaacttg 42241 ccagttgccc gcccatcctg gtgctcaccg gccgtccgga cgacacctgg ctggccagct 42301 ggtcgcgggc cgaggccgca gtgccgcatc ccgtcgaccc catcgtgctg ggccgcacgg 42361 tgctctcact gttgcgcgca cccgcccact aaccggacgc ggccggcatt cgcggcgcga 42421 acgttcagcc gccccgcatt tgaatcttcg ggtcctttct tacccgaggt cgtaattggc 42481 ccgctgccgc ttccggccgc aacgacggcg ctgtctcctc cgccgctgaa gtctctgaag 42541 cctgctgacc ttgcgcggtg cgtagtgtcg attccggaat tccagaaccc gcggattggc 42601 ctacccgcgt tgtcgacagc ggagcggcct tggccgcaac tttcggatcc acagttggca 42661 gcacccccat tgctggaact tcaagttctg gaacttccac aacggcttcc ggtggcgcgg 42721 aagccgccgg ctctggcgct cgagctgact cggtggcagt tcccggggca gagttagtgc 42781 cgccacgtgc catctgaccc agagcggcga gcgcgagcgg ggcaccgatg aagccggggc 42841 tcacaacgcc ggcatgggca ctggtagcgc tcgacgcgac gacgtctccg gcgccaacat 42901 cgccaccgcc gaaattccct tggcctacac tgccatgggc cggatcaccg gccgctaacc 42961 cggcgctagc cacgccgctt ccgacgtagc cgacgccccc gccgctagcg gttgcacctc 43021 cggtgccgac gctctcaccg ccgccggtgc cgacgctctc gccgccagta gcgccggtgc 43081 cgacgctctc accgccagta gcgccggtgg cgccggcacc caaacccgga aatcgctgca 43141 gcaaactcgc ccacggcacc acttgcgcgg caatcgccga tgccccggag tagtaccccg 43201 acatggcggc cacatccgcg gcccacatct cctcgtacac accctcggcg gcagcaatca 43261 acggcgcgtt ctgcccgaac aaattcgtca tcaccagctg cacgaatgcg tcgcggttgg 43321 cggccaccgc cgccggaagc accgtcgccg cctgcgccgc ctcgaagatg ctggccactg 43381 cgcgcgcctg tcccgccgcc ccggccgact gagccgctgc cgcggtcaac caccccgcgt 43441 agggagccgc cgctgccgcc atcgccaagg ctgccggacc ctgccacgcc tgacccgcca 43501 gcccggccgt gaccgacgca aatgattgcg ccgcggtccc caactcttcg gcaagcccgt 43561 cccaggctgc cgccgccgcc agcatcggcg cagtgcctgc accgatgaac attcgcaagg 43621 aattgatctc cggcggcagc acgacgaaac tcacagctcc cgtccttccg cttcgctgct 43681 cgatgccacg ccgacctcaa tacggccaac gattaaccgg caaatgccga gattaacaac 43741 aaatgctgcg cttatcaggg ggttagacca acattcatac aattcgccgg gacgcgcaat 43801 ccccagtttt gcttcgcagc gaccgacgcc ggacccagcc acgggttctg cttcgactcg 43861 cacaggtatg caccagcctg accccgggaa tgtggggtgg ccgttgcgcg actatgttga 43921 aggtcactgt gacggcccga agccccggtt cgtcacggca gcccggtcac cgcccggccg 43981 ccgcgctggc ggccccgtac gacggatcat ggagcgagtt gaacgtctac atacccatcc 44041 tggtactggc ggcgctggcc gccgccttcg ccgtggtgtc ggtggtgatc gcgagcctgg 44101 tcggcccgtc gcggttcaac cggtcaaagc aggccgccta cgaatgcggg atcgagcccg 44161 ctagcactgg agccagaacc tccattggcc ccggcgcggc gagcgggcag cggttcccca 44221 tcaagtacta cctgaccgcg atgttgttca tcgtcttcga catcgaaatt gtgttcctct 44281 acccgtgggc ggtcagctac gactcgctgg gcacgttcgc gctggtcgag atggcgatat 44341 tcatgctcac ggtgttcgtg gcctacgcgt atgtgtggcg ccgcgggggc ctgacgtggg 44401 attgaggtag ggcgtgggac tggaagaaca gctgcccggc gggatcctgc tgtcgaccgt 44461 cgagaaggtg gcgggctatg tccgcaaaaa ctccctgtgg ccggcaacat tcggattggc 44521 gtgctgtgcg atcgagatga tggcgaccgc gggaccaagg tttgacattg cgcggttcgg 44581 gatggaacgg ttctcggcca cgccgcggca ggcagatctg atgatcgtgg cgggccgggt 44641 cagccagaag atggcgccgg tactgcgcca gatctatgac cagatggcgg agccgaaatg 44701 ggttctggcc atgggtgtgt gcgcctcgtc aggtgggatg ttcaacaact atgcgatcgt 44761 gcagggcgtg gatcatgttg ttccggtcga catctaccta cccggctgcc cgccgcgccc 44821 ggagatgctg ctgcacgcaa tcctgaagct gcacgaaaag attcagcaga tgccattagg 44881 tatcaaccgg gaacgcgcta tcgccgaggc cgaagaggcg gcgttgttgg cccggcccac 44941 catcgagatg cgcggactgc tgcgatgagc ccgccgaacc aagacgccca ggaaggccgc 45001 ccggactccc ccaccgcgga ggtggtcgac gttcgccgcg gcatgttcgg cgtctcgggc 45061 accggtgaca cctccggtta cggacggttg gtgcgccaag tcgtcctccc tggcagcagc 45121 ccccggccct acggcggcta cttcgacgat atcgtcgacc ggctggccga ggcactgcgg 45181 cacgagcgcg tcgaattcga ggacgccgtc gagaaagtcg tggtctaccg cgatgaactg 45241 accctgcacg tccgccggga tctactgccg cgggtcgccc agcggctgcg cgacgaaccc 45301 gaattgcgat tcgagctgtg tcttggggtg agcggggtgc actacccgca cgagacgggt 45361 cgggagctgc atgccgtcta cccgctgcag tcgatcaccc acaaccgtcg cctccggttg 45421 gaagtgtctg cgccggacag tgatccgcac atcccttccc tgttcgcgat ctatccgacc 45481 aacgactggc acgagcggga aacctacgac ttcttcggga tcatcttcga cggccatccg 45541 gccctgaccc ggatcgagat gcccgatgac tggcaggggc atccgcaacg caaggactac 45601 cctctcggcg gcatcccggt cgaatacaag ggcgcgcaga tacccccgcc cgacgagcgg 45661 aggggctaca actgatgacg gcaatcgccg actcggctgg cggcgccggc gagaccgtcc 45721 tggtcgctgg cgggcaggac tggcagcagg tcgtggacgc cgcgcgcagc gcggatcccg 45781 gtgaacgcat cgtcgtcaac atggggcccc agcacccgtc tacccacggg gtgttgcggt 45841 taatcctgga gatcgagggc gaaacagtcg tcgaagcccg gtgcggaatc ggctacctgc 45901 acaccggaat cgagaagaac ctcgaatacc ggtactggac ccagggcgtc accttcgtga 45961 cccgaatgga ttacctgtca ccgtttttca acgaaaccgc ctactgcctc ggcgtggaga 46021 agctgctcgg catcaccgat gagatacccg agcgggtcaa cgtcatccgc gtgctgatga 46081 tggagctcaa ccggatctcg tcgcatttgg tcgcattggc gaccgggggc atggaattgg 46141 gcgccatgac tccgatgttc gtcggcttcc gggcacgcga gatcgtgctc acgctgttcg 46201 aaaagatcac cggtttgcgg atgaacagcg cctacatccg acccggcggc gtggcgcagg 46261 acttaccgcc caacgcggcc accgaaatcg cggaagcact caagcagttg cgccaaccac 46321 tgcgcgaaat gggcgagctg ctcaacgaaa acgccatctg gaaggcccgc acccagggcg 46381 tcggatacct ggatctgacc ggatgcatgg cactgggcat caccggcccg atactgcgtt 46441 ccactgggtt gccccacgac ctgcggaaaa gcgagcccta ctgcggatac cagcactatg 46501 aattcgatgt gatcaccgac gacagctgtg atgcctacgg gcgctacatg attcgcgtca 46561 aagagatgtg ggagtcgatg aagatcgtgg agcagtgtct ggacaagtta cgacccggcc 46621 cgaccatgat ctccgatcgc aagctcgcct ggccggccga cctgcaggtg gggcccgacg 46681 gcctgggcaa ctcacccaag cacatcgcca aaatcatggg ctcctcgatg gaagcgctga 46741 tccaccactt caaactggtc accgagggca tccgggtgcc ggcgggccag gtctacgtcg 46801 cggtggagtc cccccgtggt gagctcggcg tacacatggt cagcgacggt ggcacccgcc 46861 cctaccgggt gcactaccgg gatccctcct tcaccaacct gcagtccgtc gccgcgatgt 46921 gcgaaggcgg gatggtcgcc gatttgatcg cggcggtcgc cagcattgac ccggtcatgg 46981 gcggggtgga ccggtgacac agccacccgg tcagccggtg ttcatccggc tcggaccgcc 47041 accggacgaa cccaaccagt ttgtcgtcga gggcgctccg cggtcgtatc cgccggacgt 47101 actggcgcgg ctggaggtcg acgccaagga gatcatcggc cgctatcccg acaggcgctc 47161 ggcgctgttg ccgttgctgc acctggtgca gggcgaggat tcctacctga cgccggcggg 47221 tttgcggttc tgcgccgatc aactcgggct gaccggggcc gaggtgtcgg cggtggccag 47281 cttctacacc atgtaccgcc ggcgccccac cggcgagtac ctggtgggtg tgtgcacgaa 47341 cacgctgtgc gccgtcatgg gcggcgacgc catcttcgac cgcctcaaag agcatctcgg 47401 cgtcggccac gacgaaacca cctccgacgg tgtggtcacc ttgcaacaca tcgaatgcaa 47461 cgccgcctgc gattacgcac cggtggtgat ggtcaactgg gaattcttcg acaaccagac 47521 gccggagtcc gcgcgcgaac tcgtcgactc gctgcgctcc gacacaccga aggcgcccac 47581 ccgcggcgcg ccgctgtgcg gcttccggca aacatcgcgc atcctggcgg gtctacccga 47641 ccagcgtccc gacgaaggcc agggcggtcc cggcgcgccc accctggccg ggctgcaggt 47701 ggcaaggaag aacgacatgc aggcgccacc aacccccgga gcggacgaat gaccacgcag 47761 gccaccccgt tgaccccggt gatcagccgc cactgggacg acccggagtc gtggaccctg 47821 gccacttatc aacgccacga tcgctatcgg ggctatcagg cgttgcagaa agccctgacg 47881 atgccgcccg acgacgtgat cagcatcgtc aaggattccg ggttacgcgg acgcggcggc 47941 gcgggctttg ccaccgggac caagtggtcg ttcatcccgc agggcgacac cggcgccgcg 48001 gccaagccgc actacctggt ggtcaacgcc gacgagtccg aacccggtac gtgcaaagac 48061 attccgttga tgctggcgac gccacatgtg ctcatcgaag gcgtcatcat cgccgcctac 48121 gcgatccgcg cccatcacgc gttcgtctac gtacgcggtg aggtggtgcc ggtattgcgc 48181 cggctgcaca acgcggtggc cgaggcctat gccgccggct tcctaggccg caacatcgga 48241 ggttccggat tcgatctgga gctggtggta cacgccggcg cgggcgccta catctgcggc 48301 gaggagaccg ccctgctcga ctcgctggaa ggccggcgcg gccagccgcg gctgcggccc 48361 cccttccccg cggtggccgg tctgtatggc tgcccgaccg tgatcaacaa cgtcgaaacg 48421 atcgccagtg tcccatcgat catcctgggc ggcatcgact ggttccggtc gatgggcagc 48481 gagaaatcgc ctggcttcac cctgtattcg ctgtccggcc acgtcacccg ccccggccag 48541 tacgaggcgc cgctgggcat tacgctgcgc gagttgctcg actacgcagg cggggtgcgc 48601 gccgggcacc ggctgaagtt ctggacaccg ggcggctcgt cgaccccgct gctcaccgac 48661 gagcatctgg atgtgccgct ggactacgag ggtgtgggtg cggccggctc gatgctgggg 48721 accaaggcgc tggagatctt cgacgagacc acctgcgtgg tgcgcgcggt gcgccgctgg 48781 accgagttct acaagcacga atcgtgtggg aaatgcacgc cgtgccggga gggcaccttc 48841 tggctggata agatctacga gcggctggaa accggccggg gtagccatga agacattgac 48901 aaactgttgg acatttccga ttccatcttg ggaaagtcgt tctgcgcgtt gggcgacggt 48961 gccgcgagtc cggtgatgtc gtcgatcaag cacttccgcg acgagtacct ggcccacgtc 49021 gaaggaggcg gttgcccatt cgacccccga gactccatgc tcgtcgcgaa cggagtggac 49081 gcgtgaccca ggcggccgac actgacatcc gggtaggcca accggagatg gtgacactga 49141 ccatcgacgg cgtcgaaatc agcgtcccca agggcacgtt ggtgattcgc gccgccgaac 49201 tgatgggaat ccagatcccg cgattctgcg accacccgct gctggagccc gtcggcgcct 49261 gccggcaatg cctggtcgag gtcgaagggc aacgcaagcc gctggcgtcg tgcaccaccg 49321 tggccaccga cgacatggtg gtgcgcaccc aactcacctc cgagattgcc gacaaggccc 49381 agcacggtgt gatggaactg ctgctgatca accatccgct ggattgcccg atgtgcgaca 49441 agggcggtga atgcccgctg caaaaccagg caatgtctaa cggccgcacg gattctcgct 49501 tcaccgaggc caaacgtacc ttcgccaaac cgatcaacat ctccgcgcag gtgctgctgg 49561 accgcgaacg ttgcatcctg tgcgcccgct gcacccggtt ctccgaccag atcgccggcg 49621 atccgttcat cgatatgcag gagcgcggcg ccctgcagca ggtcggtatc tacgccgatg 49681 aaccgttcga gtcgtacttc tccggcaaca cggtgcagat ctgcccggtg ggggcgctaa 49741 cggggaccgc ctaccggttc cgcgcgcgtc cgttcgattt ggtctccagc cccagcgtct 49801 gcgagcactg cgcgtcgggc tgcgcgcaac gcaccgacca tcgccgcggc aaggtgctgc 49861 ggcggctggc cggtgacgac ccggaagtca acgaggagtg gaactgcgac aagggccggt 49921 gggccttcac gtacgcgacc cagccggacg tgatcaccac tcccctgatc cgcgacggtg 49981 gggaccccaa gggcgcgctg gtgcccacct cgtggtcgca cgcaatggcg gtggccgccc 50041 agggactggc ggcagcgcgg ggccgcaccg gggtgctggt cggcggccga gtgacctggg 50101 aggacgccta cgcgtacgcc aagttcgcgc ggatcacgtt gggcaccaac gacatcgact 50161 tccgcgcccg gccgcactcg gccgaggagg ccgacttcct ggcggcccgc atcgccgggc 50221 ggcatatggc ggtcagctat gccgatttgg aatcggctcc ggtggtgctg ctggtgggat 50281 tcgagcccga agacgagtcg ccgatcgtgt ttctgcggtt acgcaaggcc gctcgcagac 50341 accgcgtccc ggtgtacacg atcgccccct ttgccactgg tggcctgcac aaaatgtcgg 50401 gccggctgat caaaaccgtt cctggtggcg aacccgcggc gctggacgat ctggccaccg 50461 gtgcagtggg cgacctgctg gccaccccgg gcgcggtcat catagtcggg gagcgcttgg 50521 ccacggtacc gggcggattg tcggcggccg ctcggctggc cgatacgacc ggcgcccgtt 50581 tggcgtgggt gccgcggcgg gcgggggaac gcggagcgct ggaagccgga gcgttgccca 50641 cgctgttacc cggtggccgc ccgctggccg acgaggtcgc ccgcgcgcag gtgtgtgcgg 50701 cgtggcatat cgccgaattg cctgccgcgg ctggacggga cgccgacggc atcctggccg 50761 ccgctgccga cgagacgttg gctgcgctgc tggtcggggg tatcgaaccc gcggacttcg 50821 ccgacccgga cgccgtgctg gccgcgttgg acgccaccgg tttcgtggtc agcctggagc 50881 tgcgacacag tacggtcacc gaacgcgccg acgtggtgtt cccggtcgcg ccgacgaccc 50941 agaaagccgg cgcgttcgtc aactgggagg gtcgctaccg tacattcgaa cccgcgctgc 51001 gcggcagcac actgcaagct ggccagtcgg atcaccgggt gctggacgcg ttggccgacg 51061 acatgggtgt ccatctgggc gtgcccaccg tggaggcggc ccgcgaggag ctggccgcgc 51121 tcggtatctg ggacggcaaa cacgctgccg gtccccacat cgcggccacc gggccgaccc 51181 aacccgaagc tggtgaggcg atcttgaccg ggtggcggat gctcctcgac gagggccgcc 51241 tgcaggacgg cgaaccatat ctggccggta ccgcgcgcac acccgtggta cggctgtcgc 51301 cggatacggc agccgagatc ggcgccgccg atggcgaggc ggtcacggtc agcacgtcac 51361 gcggctcaat caccttgccg tgcagtgtca ccgacatgcc cgaccgcgtc gtgtggcttc 51421 cgctgaactc ggcgggctcg acggtgcacc gacagctgag ggtgacaatc ggcagcatcg 51481 tgaaaatcgg agcgggctca tgagcgtctc cccttgccgc gagcgcgcgt gttcccccgc 51541 aagcgggagg tgcccccagt acgccgacac accgattttg atgtaccagt gcggaccctc 51601 gcgcaaggag tggcggccat gaccacgttc ggccacgaca cctggtggct ggtggcggcc 51661 aaagcgatcg cggtattcgt gttcctcatg ctgacggtgc tggtggcgat cctggccgaa 51721 cgcaagctgc tgggccggat gcagttgcgg cccggcccca accgggttgg cccaaaagga 51781 gccctgcaga gcctggctga cggcatcaag ctggcgctca aagagagcat cacacccggt 51841 ggcatcgatc gattcgtata ttttgtggcg ccgatcattt cggtgattcc ggcattcacc 51901 gctttcgcgt tcatcccgtt tggtcccgag gtgtcggtgt ttggccaccg gacaccgttg 51961 cagataaccg accttcccgt cgccgtgctg ttcatcctgg gactgtcggc gatcggggta 52021 tacggcatcg tgctgggcgg ttgggcgtcc gggtccacct acccgctgct gggcggggtg 52081 cgctccaccg cgcaggtcat ctcctacgag gtcgcgatgg gcctgtcgtt cgcgacggtg 52141 ttccttatgg ccggcaccat gtcgacgtcg cagatcgtgg ccgcacaaga cggtgtctgg 52201 tatgccttcc tgttgttgcc gtcattcgtc atctatctca tttctatggt gggtgaaacc 52261 aaccgggcgc cgttcgattt gcccgaagcc gagggcgagc tggtcgcggg attccacacc 52321 gagtactcgt cgttgaagtt cgcgatgttc atgctcgccg agtacgtcaa tatgactacg 52381 gtttcggcac tggccgcgac cctattcttc ggtggctggc atgctccctg gccgctgaac 52441 atgtgggcga gcgccaacac cggctggtgg ccactgatct ggttcaccgc taaagtgtgg 52501 ggctttctgt tcatctattt ctggctgcgg gctacgctgc cgcggctgcg ctacgaccag 52561 ttcatggcgc tgggctggaa gttattgatc cccgtctcgc tggtgtgggt gatggtcgcc 52621 gcgatcatcc gctcactacg caaccagggc taccagtact ggaccccgac tctggtgttt 52681 agcagcattg tcgttgccgc tgccatggtg ctgttgttgc gaaagccgtt gagcgctccc 52741 ggcgctcgcg catcggcacg gcaacgcggg gacgaaggca ccagccctga accggcattt 52801 ccgacaccac cgctgctagc cggtgcaacc aaggagaatg caggtggcta acactgatcg 52861 tccggctctc ccccacaagc gggcggtacc cccatctcgg gctgactccg gcccgcgtcg 52921 tcgccggact aagttactgg acgccgtagc cggattcggg gtaacgcttg gttcgatgtt 52981 caaaaagacg gtcaccgagg agtatccgga aaggcccggt ccggtagcag cgcgctacca 53041 cggccgtcat cagctcaacc ggtatccgga cggcctggag aaatgcatcg gctgcgagtt 53101 gtgcgcctgg gcctgcccgg ccgacgcaat ctatgtcgag ggcgcggaca ataccgaaga 53161 ggagcggttt tcgccgggcg aacgctacgg ccgggtgtac cagattaact atttgcgttg 53221 catcggttgc ggtttgtgca tcgaggcgtg cccgacgcgg gcgctgacga tgacctatga 53281 ttacgaactg gccgacgaca accgcgccga cctgatctac gagaaggacc ggctgctggc 53341 cccgctgctg cccgagatgg ccgcgccgcc gcatccgcgg acgcccggtg ccaccgataa 53401 ggactactac ctaggcaatg tgaccgccga gggcttgcgg ggcgtgcgtg agagccagac 53461 caccggagat tcccgatgac cgcggtgctg gcttcagatg tcatcgtccg cacctccacc 53521 ggggaagcgg tgatgttctg ggtgctcagt gcgttggcgc tgctgggcgc ggtcggggtt 53581 gtgctggccg tcaacgccgt gtactcagcg atgtttctgg cgatgaccat gatcatcctg 53641 gcggtgttct acatggccca ggacgcgctg tttttgggtg tcgtccaggt ggttgtctac 53701 accggcgcgg tgatgatgct gttcctgttc gtgctgatgc tgatcggtgt ggactccgcg 53761 gaatcactga aggagacgct gcgcgggcag cgggtcgccg cggtgctgac cggtgtcggg 53821 ttcggcgttc tcctgatcag caccatcggc caggtggcga cccgaggttt tgccggacta 53881 accgtcgcca acgccaacgg caacgtcgaa ggcttggccg cgctgatttt ttcccgttac 53941 ctgtgggcgt tcgagttgac cagtgcgctg ttgattaccg ccgccgtcgg ggcgatggtg 54001 ctagcgcacc gggagcgttt cgagcgccgc aagacccagc gcgaactctc ccaggaacgc 54061 ttccgtcccg gcgggcaccc caccccgctg cccaacccgg gtgtctacgc gcgccacaac 54121 gcggtcgacg ttgccgccct gctccccgac ggttcctatt ccgaattgtc ggtcccccgg 54181 atgctgcgca cccgcggggc cgacggcctg caaacaccct cgcccggagc cgtctccggc 54241 tctttagaag gcggtgcatc atgaatccgg ccaactacct ttatctttcg gtgctgctat 54301 tcaccatcgg agcctccggt gtgctgctgc gacgcaacgc gatcgtgatg ttcatgtgcg 54361 tcgagctcat gctcaatgcc gttaacctgg cgttcgtcac cttcgcgcgc atgcatggcc 54421 atctcgacgc ccagatgatc gcgttcttca ccatggtggt ggccgcctgc gaagtggtcg 54481 tcggcctggc catcatcatg acgattttcc gtacccgcaa atcggcgtcg gtcgacgacg 54541 cgaatctact caaaggctga cgacgccacc gtgacaactt ccttggggac tcactacacc 54601 tggctgctgg tggcactgcc actggcgggt gccgcaatct tgctgttcgg cggcagacgc 54661 accgatgcgt ggggccacct gctgggctgt gccgcagcgc tggcggcatt cggggtgggc 54721 gcgatgctgc tggccgacat gctcggtcgc gatgggctcg agcgcgcgat ccatcagcag 54781 gtgttcacct ggatacccgc cggcggactc caagtcgact tcgggctgca gatcgatcag 54841 ttgtccatgt gcttcgtgct gctgatctcc ggggtcggat cgctgattca catctattcg 54901 gtcggctaca tggccgagga cccggaccgg cgcaggtttt tcggctatct caacctgttt 54961 ctggcctcga tgctgctgct ggtggtcgcc gacaactatg tgttgctgta cgtcggctgg 55021 gagggtgtgg gcctggcgtc gtatctgttg atcggtttct ggtaccacaa gccgtcggcg 55081 gccaccgcgg ccaaaaaggc attcgtgatg aaccgggttg gggacgccgg cctagcggtg 55141 ggtatgttct tgacgtttag cactttcggc accctgtcgt atgccggcgt gttcgccggc 55201 gtacccgccg caagtcgcgc agtgctgacc gcgatcgggt tgttgatgct gttgggggcg 55261 tgcgccaagt ccgcgcaggt tccgctgcaa gcctggcttg gcgacgcgat ggagggcccc 55321 accccggtgt ccgcgctgat ccacgccgcc accatggtga ccgccggagt gtatttgatt 55381 gtgcggtcgg gcccgctgta caacctggcg cccaccgccc aactggcggt cgtcatcgtc 55441 ggcgcggtga cgctgctgtt tggggcgatc atcggctgcg ccaaggacga catcaaacgt 55501 gcgctggcag cctcgaccat tagccagatc ggctacatgg tgctggccgc gggcctgggt 55561 ccggccggct acgcgtttgc gatcatgcat ctgctcactc acggtttctt caaggccggc 55621 ctattccttg ggtccggcgc ggtgattcac gcgatgcacg aagagcagga catgcgccgt 55681 tacggtggtc tgcgcgccgc cctgccggtc acgttcgcaa ccttcggcct ggcgtatctg 55741 gcgattatcg gggtaccgcc gttcgcgggc ttcttctcca aggatgcgat catcgaggcc 55801 gcattgggcg ccggcggcat ccggggctcg ctgctgggcg gtgccgcgct gctgggtgcg 55861 ggcgtcaccg cgttctacat gacgcgagtg atgctgatga ccttcttcgg cgaaaagcgt 55921 tggacgccag gcgcccatcc gcacgaggca ccggccgtga tgacctggcc gatgatcttg 55981 ctcgccgtcg gctcggtgtt ctccggtggc ctgctcgcgg tgggtggcac gttgcggcat 56041 tggctgcagc cagttgtcgg atctcatgaa gaggccaccc atgcgctgcc gacctgggtc 56101 gccaccaccc tggcgctcgg tgtggtcgcc gtcggtatcg cggtggccta ccggatgtac 56161 ggcaccgcgc cgatcccgag ggttgccccg gttcgggtgt cggcgctgac cgcggccgca 56221 cgtgcggacc tgtacggcga tgccttcaac gaggaggtgt tcatgcgccc tggtgcgcaa 56281 ttgaccaacg cggtggtcgc ggtggacgac gcgggtgtgg acggctcggt taacgcgctg 56341 gcgacgctcg tgagccagac ttcgaatcgc ctgcggcaaa tgcaaaccgg cttcgcccgt 56401 aactacgcgt tatcgatgct ggtaggagcg gtgttagtgg cggcggcgct gctggtggtg 56461 cagctgtggt gaataacgtg ccgtggctga gcgtgctctg gctggtgccg ctggcaggtg 56521 cggtgctgat catcctgcta ccacccggtc ggcgccgact cgccaagtgg gccggtatgg 56581 ttgtcagcgt cctgacgttg gcggtgtcga tcgtcgtcgc ggccgaattc aagcccagcg 56641 ccgagccgta tcagttcgtc gaaaagcatt cctggatacc ggcgttcggc gccggctata 56701 cccttggtgt ggacggcatc gcagtggtgc tggtgttgtt gaccacagtg ctgattccgt 56761 tgctgctggt ggccggctgg aacgacgcaa ccgatgctga cgacctgtcc cccgcaagcg 56821 ggaggtaccc ccagcgcccg gctccgccgc gcttgcgatc gtcaggtggc gaacgcaccc 56881 gaggcgtgca cgcctacgtg gcattgacgc tggccatcga gtcgatggtg ctgatgtcgg 56941 tgatcgcgct ggacgtgctg ctgttctacg tgttcttcga ggccatgctg atcccgatgt 57001 acttcctcat cggcggcttc ggccaggggg ccggacgctc gcgtgccgcg gtgaagttct 57061 tgctgtacaa cctgtttggc gggttgatca tgctggcggc ggtgatcggg ctgtatgtgg 57121 tgaccgcaca gtacgattcg ggcaccttcg acttccgtga gatcgtggcc ggcgtggcgg 57181 cgggccgcta cggagcggac ccggcggtgt tcaaggcgct gttcttgggc ttcatgttcg 57241 cgttcgcgat caaggctccg ctgtggccgt tccatcgctg gctgccggac gccgccgtcg 57301 agtccacccc agcgaccgcg gtgctgatga tggcggtgat ggacaaggtc ggcaccttcg 57361 gcatgctgcg ctactgcctg cagctgtttc ctgacccgtc aacgtatttc cgtccgctga 57421 tcgtgacgct ggccatcatc ggggtgatct acggcgcgat cgtggcgatc ggccaaaccg 57481 acatgatgcg gctgatcgcc tacacctcga tctcgcactt cgggttcatc atcgcaggca 57541 tcttcgtcat gaccacccag ggccagagcg ggtcgacgct gtacatgctc aaccacggcc 57601 tgtccacggc ggcggtgttc ctgatcgccg gtttcttgat agcgcggcgc ggcagccgat 57661 cgatcgccga ctacggcggt gtccagaagg tggcgcccat cctggccggc acgttcatgg 57721 tctcggccat ggccaccgta tcgctgcccg gcctagcccc gtttatcagc gaattcctgg 57781 ttctgctggg cactttcagc cgctactggc tggcggcggc gttcggcgtt accgcactgg 57841 tcctctcggc cgtttacatg ctgtggctct accagcgggt gatgaccggt ccggtagccg 57901 aaggcaacga acgcataggg gatctggtgg gccgcgagat gatcgtggtg gcaccgttga 57961 tcgcgctgtt actcgtgctt ggggtctacc ccaaacctgt gctcgacatc atcaatccgg 58021 cggtcgagaa caccatgacc accatcggcc agcatgatcc cgcgcccagc gtggcacacc 58081 cggttccggc cgtgggcgcc tcccggacag ccgaaggacc gcacccatga tcctgcccgc 58141 cccgcacgtc gagtacttcc tgctcgctcc gatgctcatc gtcttttcgg ttgcggtcgc 58201 cggtgtgctg gccgaggctt tcctgccgcg ccggtggcgc tatggcgccc aagtgacgct 58261 cgcccttggc gggtcggcag tggcactcat cgcggtcatc gtggtggcca ggtcgattca 58321 cgggtcgggt cacgccgcgg tgctgggggc catagccgtg gatcgagcga ccctgtttct 58381 gcaaggcacc gtactactgg tcacgatcat ggcagtcgtc ttcatggccg aacgcagcgc 58441 ccgggtgagt ccgcaacgcc agaacaccct cgctgtggcg cggctccctg gactcgattc 58501 gtttaccccg caggcttccg ccgtgcccgg cagcgatgct gagcgccaag cggaacgggc 58561 gggagccacc cagacggaac ttttcccgct ggcgatgctg tccgtcggcg gcatgatggt 58621 gtttcccgcg tccaacgacc tgttgacgat gttcgttgcg ctggaggtgc tatcgctgcc 58681 gctgtacctg atgtgtgggc tggcccggaa tcgccgcctg ctgtcgcagg aagccgcgat 58741 gaagtacttc ctgctgggcg ccttctcgtc ggcgttcttc ctctacggcg tcgcgttgct 58801 atacggcgcg accggcacgc tgaccttgcc gggtattcgg gatgcgttgg cagcgcgcac 58861 cgacgactca atggcgttgg ccggcgtcgc gctgctcgcg gtcggcctac tattcaaggt 58921 cggcgcggtg ccattccact cctggattcc cgatgtgtac cagggcgcac ccaccccgat 58981 caccgggttc atggcggccg ccaccaaggt cgcggcgttc ggtgcgctgc tccgggtggt 59041 ctatgtcgcg ctgccgccgc tgcacgatca gtggcgcccg gtgctgtggg cgattgccat 59101 cctcaccatg acggtgggca ccgtcaccgc ggtaaaccag accaacgtca agcgtatgct 59161 ggcctattca tcggtcgcgc acgtcggttt catacttacc ggcgtgatcg ccgataatcc 59221 ggcgggtctt tccgcgacgt tgttctatct ggtcgcctac agcttcagca cgatgggtgc 59281 gtttgccatc gtgggtctgg tccgaggcgc cgacggctca gcaggttcag aggatgccga 59341 cctgtcccac tgggccgggc tgggacagcg ttcacctatc gtgggcgtga tgctgtcgat 59401 gtttctgctg gccttcgccg gcatcccgtt gaccagtgga ttcgtcagca agttcgcggt 59461 gtttagggcc gccgcttccg ccggcgcggt gccgctggta atcgtcggcg tgatctccag 59521 cggcgtcgcc gcctacttct acgtgcgggt gatcgtgagc atgttcttca ccgaagaatc 59581 cggtgacaca ccacacgtgg cggcacccgg cgtgctgagc aaggccgcca ttgcggtatg 59641 cacggtagtc accgtggtgc tggggatcgc cccgcagccg gtgctcgacc tggccgacca 59701 ggccgcccag ttgctgcgct gaatccgtta gggctgaccg aagaagcccg actggtcact 59761 gccctgattg aagccccccg agctgtggtc acccgtgttc gccacacccg tgttgagggt 59821 gcccgagttc gcaatgcctg tggtctgcag gccagagttt gcgatgccca cggtgccggc 59881 acccgagtta tagaagccga cgttgaagcc gccggagttg gtgttattga tgcccgactg 59941 aacgtcaccg ttgttcccat agccagccga aacattgccc gtgttaaaga agcctgagga 60001 attcatgccg gtgttgccga agcccgagct cgaaacggat tggtcgaccg agcttccaaa 60061 cccggtgttc cggtcgcccg agtcgaaacc gcccgtattg atgctgcccg agttcgcgaa 60121 tcccgtattg atactgcccg cgtttgcgaa gcccacgttt agggtgcccg cgttgccaaa 60181 gcccacactt tggttgcccg cattgccaac gcccacgtta aaggaaccgc cgttcccgac 60241 gcccatgtct tcgttgcccg cgttcccgat gcccatattg aagaagccgg cgtttccgaa 60301 gcccgtgttg gtgtcgccgg cgtttccgaa gcccgtgttg atgtcgcccg cgtttccaaa 60361 gccgaagttg ttgttgcccg aattgaagaa gcccacgttg ttgttgccag agttgaagaa 60421 accgatgttg ttgttacccg agttcccgaa acctagattc ccgatgcccg agttcagcgc 60481 gccaatgccc accaagttgt cgccggtgag cccaaaaccg atgttgttgt tgccattgtt 60541 cccgaggccg aggttattgt cgccgttgtt tccgaaaccg atgttggagg agccgatgtt 60601 tccactgccc aagttgaagg aaccgagatt tccgccgccg aagttggtac ttccggtgtt 60661 tccactgccc aggttcccac tgccaaagtt tccgttgccg aggtttccaa agcctcggtt 60721 tccgctgccc agattgacat tgccaacgtt tccgctgccg agattggtgt tgccgatatt 60781 tccgctgccc aaattcgtgg caccgtcatt tccgctgccc acattggcgt tgccggagtt 60841 tccgctacct acgttggcgt tgccggaatt tccgctgccc agattgtagt caccggtgtt 60901 cccgccgccc aggttcccga cgccgatgtt gccgaggccg atcgcggcgg ccagcgccga 60961 tggcgcagct ggcaacgcct gctgcagacc aattgaccac gacgacagct gcgccgcggc 61021 cgccgatgcc ccgccgtgat agcccaccat cgcggccaca tcggcggccc acatctgttc 61081 atacatcgcc tcagcggccg cgatcgccgg cgcattctgc ccaaacagat tcgacaacac 61141 caactgcaca aacgcattac ggttggccgc caccagcatc ggatgcaccg tcgccgcccg 61201 cgccgcctca aacgcactgg ccaccgcctt ggcctgagcc gacgcgccag cggcccgcgc 61261 cgccgcagca gccaaccacc ccgcatacgg cgccgccgcc gcggccatcg ccgccgccgc 61321 cgcaccctgc caggactgac ccgccaaccc cgaagtcacc gacccaaacg aggacgccgc 61381 caccgccaac tccgcggcca aacgatccca agccaccgat gccgcaagca tcggcgcaga 61441 ccccgcaccg gtaaacatcc gcaacgaatt aatctccggc ggcaacaccg aataattcat 61501 cagcccagcc ccttccccta caggacgtcc cggccaatga ctcaggcaac ggtgcacgtc 61561 tctgtactcg tagaacaaac tgtaggaaaa cggcgcgacg aataacggcg atttcgtgaa 61621 aattctggtt cccgtcagaa gcacgccacc ctcggccacc tcgtttgcgc acgcctagag 61681 cccgcggtcg gggggtgcgg tctggatctc caaagcatct gctgctgccc ggatctcggc 61741 tagccgatca gggtccgaca acagcgccgt catcgcgaac tcgacgatct cgtccgggct 61801 gaccgcgaat tccggcagcg ccagagcgtc aaacaacgcc tgcaccagcc tggcagccga 61861 taacggatgc attgcgcgca catcaccttc gccttggccg gtctcgatca ggccaaccag 61921 cgcgcgttcc atctccgcga ctagctcccg ctccgcgacg aaggattcct gatgcaggtc 61981 cggggtgatg aggatggaaa ccagcacata gggcgaagca tgcaggtggt ccagggattc 62041 cgtcagccag cggtgcagct tgaccaccgc cggaaccggc atcgcggtga tgtgaccgaa 62101 cagctcaagc ggccactcca cggcgagccg caccagggcc gcaaggatat cgcgtttggc 62161 cgagaagtgt ttgtagatgg ccggctgctc caccccgacg gctgcggcaa tgtctcgcgt 62221 cgaggtggag ctgtaacccc gcagcgcgat gagctcggca gcggccccca ggatgcggag 62281 tgccgttggg ctccagcggc cggcctgcct cggcatgccg gcaaggctag ctggcacctg 62341 ggtggtcgcc aaccagcgcc atggcgaggt tccggtagaa cgcgagcatg ccgggccatt 62401 ctttcgagct aaggtgaccc cgttcggcga atcgcgagcc cgccccaacc tgcacggcct 62461 ccagtccgag ccggtcctcg tcattgatca tcgccatcac gaactgcgac gtctgagctg 62521 ttgctgccgc atcggcggct aactcggggg tggtgagcac gccgccgagc acctgcaccc 62581 ggtcgatgct ttgcggaata aagccgaacc acaccacccg ctcgcccgct atggccagcg 62641 cgctgttcgg aaacgtccac aacacgacca gattactttt ctgaacctcg ttgagctgca 62701 acgacttcgc ttctactgga acggtgaagg gaaccctgag gcgcaacgcc caccgcgaat 62761 actgccgaac gtccagatcg cccccaccag gaacgaacgg ctccagggtt tggcgatgca 62821 ggccgagcac gtggtagttc tcatgaccat tttccgccgc caccttccaa ttagctcgcc 62881 actcatgcga ccacgactcg acctgcacca tctcaccgag ccgatagccg gcgaattcgt 62941 cgtcagtcag gtccagatgc gccgcgattg gttcggcatc ggcatccagg ttgatccaca 63001 ccaatccatt ccaggtggcc acggcgaact gcggaagccg gcactcccta cggttgaagt 63061 ctaagttggc ggccatatgg ggcgctccgc gcaaccggcc atccagccca tagcgccaca 63121 ggtggtattg gcaggtcaac gtgtcgatgc gccccgcacc gggttccacc atcagcatca 63181 accggtgccg gcagatcggc gaaagagcgt gcagctgccc gtcgacgtcc cgcaccacca 63241 tgaccggctc ccctgcgacg gacacggtga cgtagtcacc ggtcttggcg acttggtcga 63301 catgcgcgac aagcatccag gaccggttga agatccgttc ccgctccagc tgccacagct 63361 ccgatgaggt gtaggcggcc ggcggcaggc ttagcgccgg tggattgtcg tcgaggtaat 63421 ccccgatgtc ggtaaggatg tctccgagct cggctcggtt atcagttgat aacataccct 63481 ccatgttatc gactgataac cgattgtcaa cagcgcgcac cggcccgacc ggccagccgg 63541 cggttcacct cgagaacgga cgggtggcca gcacgtaggt agccaacacg gccaacggtg 63601 ccgccaacgg cagccatggc acttgcagcg ggaacgacgt cgcagccaac ccagcgaacg 63661 tgaaaccaac ggcggcaacg gtcgtcggcc agctcccggc gacaacaccg gccccgtatc 63721 ggcacaccag gtagacggcg gcgcaaaacc ccgacaatgc ggcaagcaca tgcgtcgggc 63781 cggacaccac gatcatcacc accgacaaca ccacggcaag cgttgccgcc aggcgaaaca 63841 ccgccgccac ccctaccgca atcaccgcgg caagccccac gacaacagcc agcccgtgcg 63901 atcccacagc ggccgacccc accatcatca gtccgaacac cgtggagagc ccacgagtac 63961 ccgggtgcgc aaacgaggtc atggcagcct cgcccggcta gctctgcccc gtccgcgacg 64021 acggcgattg ggcaacgcac ccatcgactg ctgaagcgag tgatccgccg gccaggacag 64081 cacgtcgacc ccgatggtgg ccatgtcgcg atacatcgcg gagcgctgca gcgcccacat 64141 ccggaccacc aggggatcca gttggtcctg gagcggacag ctatcaagaa cgtcgacagc 64201 aaccacgacg tggccgcgtt tacgcaggtc gatcaacgcc agcgcgaact cggtatccag 64261 cagcgtggaa aacgcaatga caaccgctcc tgcgggaaca gctgcgcgcg gagccagcgt 64321 cccggtggtg ttttcgaacc cttccccggc gccgagcacg gtgtcgagca cccgatagaa 64381 ctggcgctgc ccgatgtcgg cgcccagcca tcgcggccga ttgccgccca gcgcaacgat 64441 cccagcacgg tcaccgtttc gcagcgcggt ttgcaccacc tgagcagcac cccgcacgac 64501 tcgttcggtg gcctcggtcg ccggacccgc cggctgtcga tacatgtcga tcaacaccac 64561 cacgtcagcg gcccggtcgg tcaaccgcct tgtcacgtgc agtcggccac ggcgcgcgct 64621 taccacccag ttcacggcac gtagctggtc gcccgggaca tatgggcgaa tgtcggcgta 64681 ttcgacaccc ggcccgacgt gccgggtgag atgagctccc aggcggtcga gcaattcggt 64741 ctgcggcagt ggcgtcgact gcggcggtgt cagcggaaac acgacgattt cggcggcgtc 64801 gacggttccg gctcccatca acaacccacc gcgtgcgacg acggcgaccc gggcccggat 64861 aggatagcgc ccccagcgtt gcgccaccgc ggaaaccgtt gtcgtccggc gtgacacgga 64921 ttccagagct tcgaactgca ttcccgccaa cgccgatacc gtgagttcga ccgcggcgtc 64981 cacggattcc gttgtgaccc acacggtcac tcgcacatgt tcgttctcga aacatcgctg 65041 cgaatccggg tcaccgtgca cctggatcac cgggaccgga cgctgccagc tgatcgagca 65101 caacacgccg agcagcggcg ccgcgaacgc aatcagctgc caacgaccag cgacgaccgc 65161 tgcggctagc gcaactccgg cacaggtggc aatcgccagc gtcagttgtg atgcacgcca 65221 gcgcaactcg acttcacacg tttggatcac atcgcgccgt agttcatcca gccaacccgc 65281 tacgttccac taattcgggg aacaggcaga cgccgcaaca gctctgagac cacatcagcg 65341 cccgcaatct tgcgcaccca catctccggg cgcaatgtga tccgatgcgc gacggccgcg 65401 gtcgcaagtt ccttgacatc ttcgggtatg acgtagtccc ggccgagcaa cagagcgcgg 65461 gcacgggaga gctggaccag gtcgagttcg gctcgcgggc tggcgccgac ggccacctgc 65521 ggatggtgcc gggtagcgtt ggccaacgac accacatagt gcaagacgtc ctcgtgcacg 65581 gtgacctgct cgaccgattc acgcatggcc aacagatcgt ggcagtccac cacctgattc 65641 accgtcggat ccgcagaacc gcgttccagg cgacggcgca gcatcgaggt ctcgtctcgc 65701 tcggagaggt agcgcagttc caaccggatc gcgaaccgat ccagttgcgc ctccggcagt 65761 ggatatgtgc cctcgtattc gatcggattg tcggtcgcca gaacgatgaa tggcattgcc 65821 agtttatggg tttggccatc gatgctcacc tggccctcgg ccattgcctc caacagtgcc 65881 gcttgcgtct tcggcggcgt ccggttgatc tcgtcggcga gcaacaggtt ggtgaaaata 65941 ggcccggccc ggaattcgaa acgaccggac tgcatgtcat agatggtcga gccgagcaga 66001 tcggccggca gcaaatcagg cgtgaattgc actcgggtga aatcgagccc caacgcggcg 66061 gcgaaggatc gcgcgatcag cgtcttgccg aggccgggga gatcttcgat gagcacgtgg 66121 ccacgggcga gcacggcggt gaggatgagt gtcagtgcag agcgcttccc caccaccaca 66181 cgttcgattt cgtcgagcac cgcctcgcag tgggcggtgg tcgtcgcggc cggcataatc 66241 atcgttgagt catacctgtt ctaacttctg cagaatttct tccagtgccg cacggccggg 66301 gcctggttga cggtcgccgg tgtgcgtcac attgttcggg ttgacccatt cccacaattc 66361 gtcgccgaaa agcattcggc cggtggcagc aaaggcaacc gggtctttgg cctgtctatg 66421 gccggtggcg atttcgaacc gtcgtgcgag catcggacgc aaatgccggt cccagtcggc 66481 tcgagtggac tccgaccacc ggatcgtcgt ctcggtgttg gagagccacc ggcgcaaccc 66541 ctcccccaga tcgtcggagt ccggcgcagc cgtgagttcg tcccggttgc ccagcatccg 66601 gcggacgttg agcagcacca gagccagggc gagccccgac ccggcgagca cgagccgacg 66661 gtcgtgcagt atcagcgcca gcagctcaat ccccacgatg aggaaaatcc ccagggcgat 66721 aagccttttc atatagcggt ccgagtgctc agttcgtcaa gaaccagtcg aagcaaacgc 66781 atcgccacct cacggtgctc ctcgttcatc acgtgcgggc taaaacgcgc ctcggcgaac 66841 aggctcacca acgcggcggc actagcacca tggagcgcac ggtgttcgac ggctcgggcc 66901 agcacctcgg tcggggtgtc gaagtcctga ggggcaacac cgggaacatg cgacagttca 66961 cgctccatcg ccacgtaaca cgcaattatc gcctcccgtg gttcgcggcg gaggtcggcc 67021 atctcggcca gtccgatctc ggcggcacgc gccagtgatt ccgaacgcgc cgagggcgcc 67081 ggagactcga tgcgatcgcc actgatacga gccggtgccg acttgcgctg tcgtcgcgag 67141 gtaatcagcg accccgcgac gaccatcaag aacaggccga ttgtgctggc aaagagaatg 67201 ccgagcacgt cgtcattgtt gtcttgcggc ggttgcgggc gcgacggcgt ggtgctggaa 67261 gcatccggcg tagcggttga atccggtatg ggcgcagcag gaccgacatc atcgggcacg 67321 aacaaccgtg ccagcagtat cgcaatcagc agccaggcca ggattgtccc gagtccgagc 67381 aacagcacac gccagttcgg acgccctgct gcaccgccaa gcattgccga gagctccccc 67441 gcgctgggcg ccaccgggag cggatgtcgc aaccgggtga tgatggcgag cgctatcagc 67501 gcgagcgtcg cggcaagtgc ggcgacaatg aacatcagcg ccgcccggct gccgccggcc 67561 gccgcgagcg gtgcaccgtc gtcggccggc aggtggccgc gcagggcagc gccagcaagc 67621 atcaagagca cgatcacgac gacgacgcgc cctgtcggtt tgtcactacc gggcttagta 67681 ccgggcatac gcacaccact cgaccggttg cctgccgccg ttgcggcctg ggggttggtt 67741 caacctggct tggttcatac tggcacgtca gacgacactg ccgccaggag cggcgcggtg 67801 gacccctcgc acgacgatcg cggtggtttg gtccacccac gcgtcgtcca gcatgtcgtc 67861 cgggtacagc agcatccgca gcatggtggc gcccccgatc agctcgatca accggtccgg 67921 gtccacgtcg ggatgcgcct cgccgcggtc gacggcctcg cgcaggcgca tgcgcaccgc 67981 ggcgaataag tcggcaaaac gcgccagcac ccgggcgttg agttcagcgt ctgcggtcat 68041 atcggctacc agaccgggta acgcggcccg caccaccggg gtggtgaaca catcgcgggt 68101 ggccgcgatc atcattcgga tgtcggcggc gatatcaccg gccgcagcct gcagcgcggt 68161 gggcgcggcg ggaaacgcgg cctcgtgcac tagttcggcc ttgctcgacc accgccggta 68221 caacgccgat ttggtggtgc cggcgcgttc ggcgaccgcg gccaagctga ggttcgaata 68281 cccgatctgc acaagcagtt ccgccgtcgc cgacaggatc gccgagtcga tgcgcggatc 68341 acgcggccgc ccggcgccgg gggccttgtc aagggagggc aggtctgctt tcataacgct 68401 acctaaagta gcgtaattgc cgcaccaggg aggcgcttgt ggccaacgaa ccggcaatcg 68461 gagccatcga ccgactccag cgctcgagcc gcgacgtgac caccctgccg gcggtgatat 68521 cgcgctggct gtcgagcgtg ttgcccggtg gggcggcacc cgaggtgacc gtggaaagtg 68581 gcgtggactc caccggcatg tcgtcggaaa ccatcatctt gaccgcgcgg tggcaacaag 68641 acgggcgatc gatccagcag aagctggtgg cgcgggtggc gccggccgcc gaggacgtgc 68701 cggtgttccc gacgtatcgg cttgaccacc aattcgaagt gatccggctg gtcggagagc 68761 tgaccgacgt tcccgtcccg cgggtgcgct ggatcgagac caccggcgac gtgctgggaa 68821 ctccgttctt tctgatggac tacgtcgagg gcgtggtgcc gcccgacgtc atgccgtaca 68881 cgttcggtga caactggttc gccgacgcgc ccgccgagcg ccagcgccaa ctgcaggacg 68941 ccaccgtcgc agcgttggcc acactacatt caatccctaa cgcccagaac acgtttagct 69001 tcctcaccca gggccgcacc agcgatacca cgctgcaccg gcacttcaac tgggtacggt 69061 cctggtacga cttcgcggtg gaaggcatcg gtcgatcccc actactggaa cggactttcg 69121 agtggctgca aagccactgg ccggacgacg ctgccgcgcg cgagccggtg ttgctgtggg 69181 gggacgcgcg ggtgggcaac gtcttgtacc gagactttca gccggtggcg gtgctggact 69241 gggaaatggt ggcgctgggt ccacgggaac tcgacgtcgc gtggatgata tttgcgcaca 69301 gggtatttca ggagcttgcc ggtttggcga cgctgccggg tttgccggag gtgatgcgtg 69361 aggacgatgt gcgcgccacc taccaggcgc ttaccggcgt ggaacttggt gacctgcact 69421 ggttttacgt gtactccggg gtcatgtggg catgcgtgtt catgcgcacc ggtgcgcggc 69481 gagtgcactt cggcgagatc gagaagcccg acgatgtgga gtcgctgttc tatcacgccg 69541 gcttgatgaa gcatcttctt ggagaggagc actaatgccg caaatgctag gcccactcga 69601 cgagtacccg ctacatcagc ttccccagcc gatcgcctgg ccgggctcct ccgaccgcaa 69661 cttctacgac cgctcctact tcaacgccca cgaccgcacc gggaacatct ttctgatcac 69721 cggtatcggc tactacccta acctgggcgt gaaagacgcg ttcgtgctga tcaggcgtgc 69781 ggacatacag accgcggtgc atctttcgga tgccatcgac tccgaccggc tacaccagca 69841 cgtcaacggt taccgggtgg aggtcgtcga gccgctgcga aaactgcgta tcgtgctcga 69901 cgaaaccgaa ggtgtggcgg ccgatctcac ctgggagggc ctgttcgacg tcgtccagga 69961 acagccgcac gtcttgcgct ccggcaaccg ggtgaccctg gatgcgcagc gcttcgcgca 70021 gctgggcacc tggagcggcc gcatcgtcgt cgacggcgaa cggatcgccg tcgatccggc 70081 gacctggctc ggcagccggg accggtcctg gggcatccgg ccggtggggg aaccagaacc 70141 ggcgggccgg cccgccgacc cacccttcga gggcatgtgg tggctgtatg tgccgttggc 70201 cttcgacgac ttcgccgtcg tgctgatcat ccaggaagaa cccgacgggt tccgctcgct 70261 caacgactgc acccggatct ggcgtgacgg ccacgtcgag cagctgggct ggccgcgggt 70321 gcggatccac taccgctccg gcacccgcat cccgaccggg gcgacgatcg aggcaagcac 70381 ccccgacggc gcgccggtgc acttcgacgt ggagtccaaa ctggcggtgc cgacccatgt 70441 cggtggcggc tacgggggtg actcggactg gtcacatggc atgtggaagg gcgagaagtt 70501 cgtcgagcga agaacctacg acatgaccga tccgacgatc atcgcgcggg ccggcttcgg 70561 cgtcatcgac cacgtcggtc gcgcgctatg ccgcgacggc gacgggaatc cagtgcaggg 70621 ctggggtctg tttgaacacg gggcgctggg ccgccacgac ccatcggggt tcgccgactg 70681 gtctacgctg gcgccctagg cgcttcaggc ttacttcggc accggtgagg ctatccgcat 70741 tcgcgagtcc agggttcctg ggcgccggcc gggaaacggc ccgaaaacga cggcagccgg 70801 aatagccgac cggaaccgcc gaaatgcggt tgactagagc ggtgacaaac ccaccgtgga 70861 ctgtcgatgt tgtcgtggtg ggcgcgggct tcgccgggct ggccgcggcc cgcgagctga 70921 cgcgacaggg tcacgaggtg ctggtgttcg aaggccgcga tcgggtgggc ggccgctcgt 70981 taaccggtcg cgtggcaggg gtgcccgcgg atatgggcgg ctcgttcatc ggcccgaccc 71041 aagacgccgt gctggcgttg gccaccgagc tggggatccc gacaaccccg acccaccgcg 71101 acggccgaaa cgtcatccag tggcggggat cggcacgcag ctatcgtggc accatcccca 71161 agctgtcgct gaccgggctc atcgacatcg gccggttgcg ttggcaattc gagcgaattg 71221 cccgcggcgt tccggtggcc gccccctggg atgcgcggcg cgcgcgtgaa ctcgacgacg 71281 tgtcgctcgg ggagtggttg cgcttggtgc gcgccacatc gtcctcgcgg aacctgatgg 71341 ccatcatgac ccgggtgacc tggggttgtg agcccgacga tgtctcgatg ctgcacgccg 71401 cccgctacgt acgcgcggcc ggcggcctgg accggctgct cgacgtcaaa aatggtgccc 71461 agcaggaccg tgtgccgggg gggacacagc agatcgccca ggcggccgcc gcccaactcg 71521 gcgcacgcgt cctgctcaac gccgcggtgc gtcgcatcga ccggcacgga gcgggtgtga 71581 cggtcacgtc cgatcagggt caggccgagg ccgggttcgt catcgtcgcc attccaccgg 71641 cccatcgcgt ggccatcgag ttcgatcccc cgctgccgcc ggaatatcag cagctcgccc 71701 accattggcc gcagggccgg ctgagcaagg cctacgcggc ctattcgacg ccgttctggc 71761 gggccagcgg gtattccggc caggcgctgt ccgatgaggc gccggtgttc atcaccttcg 71821 acgtcagtcc gcacgccgac gggccaggca ttctgatggg gttcgtcgat gctcgcgggt 71881 tcgactcgct acccatcgaa gagcgccgcc gcgatgcatt gcgctgcttt gcgtcgctgt 71941 tcggcgacga agcgctcgac ccccttgatt atgttgacta tcgttggggt acagaggaat 72001 tcgcgccggg tggtccgacc gcggcggtac cgccggggtc gtggacgaaa tacggtcact 72061 ggttacgtga gccggtcggt ccgattcact gggcgagcac tgagaccgcg gacgaatgga 72121 ccgggtattt cgacggcgcc gtcagatccg gtcagcgtgc cgccgccgag gtcgccgccc 72181 tgctatgagc tgatccgccg gtcccggacg tgccgggtca ccgattcggc cagcgcccgc 72241 aggtggctgt tcacctcttg gtgccgttcc agcatcgagc agtggccgcc gggcagttca 72301 acgaggccga cgacattggg cgcggtgcgc gcaatcctgc gggactggct gatcggcgtt 72361 agtcgatcac gtacgccgcc gatcaccagg gttggcaccg tcagaccatc caggttgagg 72421 tgtgccgacc ctacttcctc gacgagcatc ttcgcgcagc cgccgcgccc cgcggcagac 72481 gtctgggtga acaactcata gaccagtctc gtggcgctgg ggtccgcgtc ggcggcgacc 72541 gccagcgtgg agatcacgtg ccggcttaag gccctggccg cgccggggag tggaaacccg 72601 ccgaacgtgt tgaccaggct ccggccggcc agcacccgaa ccggggacaa ctcgcgtggc 72661 accgacagca gtttcacctt gcgcaccagg tcgccggtgg tggtgttgat cagcgcgacg 72721 gcgtccgtgc ggcggcggac tttgtggcgg tagcggtccg accaggcggc aatggtaatg 72781 ccgcccatcg agtgcccagc gaccaccgca cgctcgcgcg gggccaacgt agcgtccaac 72841 accgaatcga ggtcggccgc aaggtgattg aggctgtagg cgccacgccg tgggacaccg 72901 cttcgaccgt ggccgcgatg gtcgaaggcg atcacccggt agtcgccggc caggtcggcg 72961 atttggtatg cccaggcccg gatggcgcag acgaaaccgt gcgtcagcac aatcggatag 73021 ccgtgaggcg gcccgaacac ctgggtgtgt aacggggtgc cgtccgccgc acggacggtc 73081 aaggtgcggc taggcggtag gacgtctgga atctgggtag ccccgctgct tcgagtgggt 73141 ctccgagcac tcatcgccgc tcccccttcg acgcggcccc gttgccgcct tccggatgtc 73201 gcccactcta gcgtgcagtt acttacgggt agctggaaat cgctgaagca taggatcaca 73261 gaataataac gtcgcggccc ctgctctcag ctggtttcgc atcgccagcc gatcagtagt 73321 cgtctcagta atcgtcgagg gcggccacgt tgcgccaact cggccacgtc gtctcccaga 73381 tccggtgaat tcggccgttg cggtaggcgg caatgagtac cacctcgatg cgggtcggct 73441 cctcgccagg tcgcgacgtg gtgatccaca cccgcccggc aaccttgtct gggcctctac 73501 ccatgcgtgc tcgtcgtatt cgaccgcgta gctgatcgcc gtggcgtaga gcttgcggtg 73561 gctatcgcgg aattttgcga agctctggct cagcccgtcg gagtacatca ggaagtctgg 73621 gtcgtagtag tgctcgatca gctccgcgtt tttggcgacg accatccgat cgaacatttc 73681 ccgaagcagc gcaacggaca ttcggcgatc ctaaaccctg gccgccggcc atctcacaac 73741 gtgagcgtgg acgaatcccc atccattgcg atgacgagtt cagaccggac gggccgttgc 73801 ctgatcaatc aggacctccg ctgccgctcg ggcgtgcgcc caggggccgg catcgtcgag 73861 ggaggtggac agtgcggccg cgccctcgaa cagcacggcg agttgattgc ccaggctgcg 73921 cggatgcgct gcgccggctt ctcgggccag ccgggcgagg cctttgatgt agtcgcgttt 73981 gtgcgagtgg acgatccgct cgactccggg catctccccg gccgcctcga ccgccgcgtt 74041 gtggaatgga caacctcgca tccgcccatc gcccctgttt ggacgatcga acaatgcgag 74101 cagccgctcg cgtggtgtcg cgttggatgc cttgggcatc ttgtcggcct cgccggcggc 74161 ttgccggagc ccgcgcaggt actcctccac caacgcggac ttactcggaa agtgttggta 74221 gagagtccgc ttggataccg aagccttgtt cgcaatcagt tcgaccccgg tggcgttgat 74281 gccctcgcag tagaacagct ctgcagccgc cttcaagata cgctgacgag cgccgcggcc 74341 cccgcgcctg gggggttccg ttgttctggt gaccggcggc atagtgctga gtataccgac 74401 ctgtttacaa caccccttag cgcgtgtacc gtcaaagcac aaagtacacc aatcggttta 74461 ctgtaggagg tctcatgact tcactagccg agcggaccgt gctcgtcacc ggcgccaacc 74521 gcggcatggg ccgcgaatac gtcgctcagc ttctcggtcg caaagtggca aaggtctatg 74581 ccgctacccg caacccgctg gcaatcgacg ttagcgatcc gcgcgtgatt ccgctccaac 74641 tcgacgtcac cgacgcggtg tcggtcgccg aggcagccga cttagcaacc gatgtcggca 74701 ttctgatcaa caatgccggc atctcccggg cgtcctcggt gctcgacaag gacacatccg 74761 cgcttcgcgg cgagctggag acgaacctgt tcggaccgct cgcgctggcc tccgcgttcg 74821 ccgaccgcat cgccgagaga tccggtgcca tcgtcaacgt ttcctcggta ctcgcctggc 74881 ttccccttgg catgagctat ggagtgtcca aggcggcgat gtggagcgcg acggagtcga 74941 tgcgtatcga gctggcgccg cgcggtgtgc aggtggtggg cgtctacgtg gggctggtcg 75001 acaccgacat gggtcgattc gccgacgcgc cgaagtccga tcctgccgat gtggtccgcc 75061 aggtgctcga cggaatagag gctggcaagg aggacgtgct ggccgacgag atgagccgtc 75121 aggtgcgcgc gtcgctgaat gtccctgcgc gggaacgtat cgcgcggttg atgggtaact 75181 gagtccgaaa gtcgatatgg ccatgtccgc caaggcctca gacgatattg cctggctacc 75241 ggcgaccgct caactcgcgg tgctcgccgc caagaaggtg tccagcgcgg agttagtcga 75301 gctgtatctt tcccgaatcg acacgtacaa cgcgtcgctc aacgcgatcg tcaccgttga 75361 ccccgacgcc gcccgacgcg tcgccaagcg gtccgatgcg gcacgagccc gcggcgacga 75421 actcggcccg ttgcatgggt tgccgatcac cgtcaaggac agctatgaga cggccggcat 75481 gcgcacgacc tgcggtcgcc gcgaccttgc cgactatgta cccacccagg acgccgaggc 75541 ggtcgcccgg ttgcgccggg ccggcgcgat catcatgggc aagacaaaca tgcccaccgg 75601 caaccaggac gtccaggcca gcaatccggt cttcggccgc accaacaacc catgggacgc 75661 cgcgcgcacg tccggcggct cggccggcgg cggggcggcc gccaccgcgg ccgggctgac 75721 cagcttcgac tacggctcgg agatcggcgg ctctaccagg atcccggctc attactgcgg 75781 tctgtacggc cacaaatcga cctggcgctc ggttcctctg gtcgggcaca ttcccagcgc 75841 accaggtaat cccgggcgat gggggcaagc cgacatggcc tgcgcgggcg tgcaggtgcg 75901 cggtgcccgc gacatcatcc ccgcactgga ggcgaccgtc gggccgatgc gggcggacgg 75961 aggattctcg tatgcgctcg ctccgccacg agccggcgcg ctcaaagact tccgggtcgc 76021 ggtctgggcc gaggacccgc attgcccaat tgacgccgac gtgcgtcggg ccatggatga 76081 tgctgtcgcc gcgctgcgcg ccgcgggcgc acacgtcgtt gagcagcccg ccaccatccc 76141 ggtcgatatg gcggtgtcgc acaacatctt ccagagtctg gtgttcggcg ccttcgctgt 76201 cgaccggtcc accctcagcc cagcctccgc cgccgcgctc ggattacgcg cggttcggca 76261 tcctcggggc gaagccgcca acgccctggg tgcgacgcta cagagccacc gtgcgtggtt 76321 gttcgccgat gcggcgcgcc acgaaatgcg cgaccggtgg gccggattct tcaacgagtt 76381 cgacgtgctg ctcctgcccg tcacgcccac ccccgcgccg ctccaccaca acaaggacca 76441 cgaccggttg ggccgcacca tcgacgtcga cggcgtctca cgatcgtact gggaccaact 76501 caaatggaac gcgctggcca acatcgccgg caccccggcc accaccatgc ccatcaccac 76561 cacagctacc ggactcccga tcggcatcca ggcgatgggg cccgcgggcg gagaccgcac 76621 caccgtagag ttcgccgccc tgctcaccga agtcctaggc ggcttccgcg ttccccctct 76681 ttaggaacgc tcgggcaggg ccgcaataac ctcggcgagc cgatcgggct gctccgctgt 76741 cgtcaggtgg ccgcccgcaa gctcggtgat ttccaccgaa tccgcaagcc gctctcgggc 76801 gagccgcagt tgctctccct cgaatggatc ctcggcgctg cccaccacac caaaggcgac 76861 ctcatcgccc agcgccgaaa tgatccgcgc caggtcccag cgcgctgcgt gctcgcgatg 76921 ctcgtccacg aagcccgccg tggcgggcag cacgcgcacg ccgtcgcgcc ggctgatcgc 76981 gtcgtggagc tccttcatct ccgctgcgct taatgggtat ccgcgcgaga agacggggcg 77041 caagaatggg gcgaacatgc gccatgagcg ctggccgatc ggcgtgatcg ccgcgccgag 77101 cggcgatgtg agcagcggcg tcgtatacca ggcgtgggtg tggccgtcgg caaagatgcc 77161 gccgttggcg agcaggcaag ccgtgattcg ggtccgctga tcgtttcccg cccgctcgcg 77221 atcgatccgc cgcgccagca gctcaaggct gacgatgcag gagtagtcga aggcaacgac 77281 gacggtctgc gctatcccct cggcgtgcca gagggcttcg acgagatccg cgcgctcgaa 77341 ggtcgagtac gggtaatccc ggggtttgtc ggagtcgccg tggccgatgt agtccaggta 77401 gatgcggggg aagtggaatc gcgagctcaa gaaagcttcc accttcgccc aaccgtagga 77461 accatccggc cagccaggca ggaacgttcg cgtgaccccc gtcccagcag cgcgccgtat 77521 gaacgcgcgc agcggcgaac gtgggttgat gcccggccgc tcagcgtcgt agcccaccct 77581 ctccccagcg gagaaccact cctgtgcgct gatgagcgcg ctcgcccggt gcgtcatcgc 77641 gcgctcgcta gccgttggcg gaggttgtcg aggtccatgt cggtgcatct ccgcaaccaa 77701 agtacaccga taagtttacg tgtcgcatta accgatgtac agtgtcggtt ataagtacac 77761 cgatcagtat acaaggagtc ggcgtgcccc agagacaggc cggcgacatc ggcgcgacat 77821 accaggacgc gcccacgaag agcatcaatg tgggcggaac gcgttttgtc taccggcggc 77881 tcggtgctga tgccggcgtg ccggtgatct ttctgcacca cttgggcgcg gtcttagaca 77941 actgggatcc acgggtcgtc gacggcatcg ccgccaagca tccagtggtc actttcgaca 78001 accgcggtgt cggcgcttcg gaaggccaga cgccggacac cgtgaccacc atggccgacg 78061 atgcgatcgc ctttgtccgt gccctggggt tcgatcaggt tgatctcctt ggattctcgt 78121 tgggcggctt cgtcgcgcag gtgatcgcgc agcaagaacc gcagctcgtt cgcaagatca 78181 tcctcgcggg taccggaccg gccggtggtg tcggcatcgg caaggttact ttcgggacga 78241 tccgcgagag catcaaggcc acactgactt tcagggatcc caaggagttg cggttcttca 78301 cgcgaaccga cagcggcaaa tcggcggcgc gacagttcgt gaagcggctc aaggaacgga 78361 aggacaatcg cgacaaatcg attacagtgc gcgcgttccg ctcccagctc aaggccatcc 78421 atgcatgggg cacgcaaaag ccttcggact tgacgagcat cggccatccg gtcctgatcg 78481 caaacggtga cgacgacacg atggtgccca ccagcaactc gttggacctc gctgaccggc 78541 tgcccgacgc cacgctgcgc atctatcccg acgccggcca cggcgggata ttccagcacc 78601 acgcacagtt tgtggacgat gccctgcagt ttctcgagtc gtgaagcgat ttcgcatgac 78661 caccaaagcc acgcccagac cagttggatt cgccgctcct ccccaccgtt tcgcggtatc 78721 ggcagagcgc acccatggat ctatcaccgc accggcggac gagtcggctg caagttgcga 78781 ctcggcgccg gattccgcaa accggtgccg acactgctac tcgaacaccg gagccgcaag 78841 tccggcaaga acttcgtcgc accactgctt tacatcaccg accgtaacaa tgtcatcgtc 78901 gttgcctctg cccttgggca ggcagaaaac ccgcagtggt atcgcaacct gccgcccaat 78961 cccgacaccc acattcagat cggatccgat cgccgcccgg tgagagccgt cgtggccagc 79021 tcggacgagc gggcgcgcct atggccgcgc ccagtagacg cctacgccga cttcgattct 79081 tgccaaagct ggaccgagcg tgggattccg gtgatcatct tgcggccacg ctaataggcg 79141 tcggcctgct ccgcgtggtc gagcgatccc ggtgcggtta cccgctacgg ggtgctttcg 79201 gcaccgcgat cggctaggcc accgagggag cagacatcga atacagcggc cgaatcaagt 79261 cgctggaccc ggcaactccc acgggtgtcg tcaccgtcgc cgcgatgact ggcggccgga 79321 agacctttgg ccaggcgacg ttgaacgtcc gcttccgctg acccggcggc ctggtgacgg 79381 cggccgagga caaagaagag cggcttcggc tgtccggaac ccggatcgaa ctcgaggagc 79441 tacttcagct tccggtcgat gttgcgtacg agggcctgtt gacggacgac gtttccgaat 79501 ccgttcgcaa aaagctcatt acgctacgag ccggtccctc aagaaccgcc tgctcgaatc 79561 tgcgcaaccc cgctggcgtt ggggcggacg acggtgctcg gcgtgatgtg gtgcaccaaa 79621 gggacattgc cgacggaact ggcgttgagc cagcaacaca ccgttgatcg catgagtgat 79681 gtccacccaa ccgcggtcac cgacaacggg gatccagtcg ggatcatcgc tggcataagg 79741 atatcggcct gcaccggcat tgtgtgctca cggccatcgc tgcctgggac caatcaccag 79801 cccctggaag gtcgactaca gccacaagcc cgacgatggt cgacagatca agatacgtct 79861 ttcgacaaaa caagatccaa tggtcgacaa aacaggacaa actattcgac aaatcgggat 79921 cagatgtacg acaaaacagg agtactttga cgttgtggtg catgatgagg ctggtcacga 79981 gctgatcgag cggcacatgc tcgaacagtt gcgcgaggtt gcggagtaca cccgtgtcgt 80041 gctgatcaat ggtccacggc aggctggtaa gacgacgctg ctccaacaat tgcacgccga 80101 gctaggcgga tggctgcgtt cgttggatgt tgacgtcgaa cgcgcgtcgg cgcgagccga 80161 tcccgagggg tacatcatgt ccgcgccgcg cccgacgttc ttggacgagg tccagtgcgc 80221 cggggatccg ttgatcctgg cgatcaagac ggcaaccgat cgtgaccgcc ggcccagaca 80281 gttcttcctg tcggggtcga cccgattcct gacggtgccg acgctgtcgg aatcactggc 80341 cggacgggtt gcgatcctcg acctctggcc gctgtctgtc gctgaacgat cgggtgtccg 80401 gccggagatc attgcgcaac tgttcactga accccaagtg gtcctgggca cggagcccgc 80461 cccggtcacg cgacatgagt atctgcagct ggcctgcgcg ggtggctttc cggaagttgt 80521 gcagcgcccg gcgggtcgcg cccgcagccg gtggttctcg gactatctgc gcacggtgac 80581 gcagcgcgac gtgcgcgagc tgaagcggat cgagcagacg gatcgcctgc cgcggttcat 80641 gcgctacctg gccgctatca ccgcgcagga gctgaacgtg gccgaagcgg cgcgggtcat 80701 cggggtcgac gcggggacga tccgttcgga tctggcgttg ttcgagacgg tctatctggt 80761 acatcgcctg cccgcctggt cgcggaatct gaccgcgaag atcaagaagc ggtcaaagat 80821 ccacgtcgtc gacagtggct tcgcggcctg gttgcgcggg caaagcgccg actccctggc 80881 caggccaacc gcggagggcg cgggcccgat catggaaacg ttcgtgatca acgagctgat 80941 gaagctacgt gcggcgaccg aactcgaggt tgacctgtat cactttcgcg atcgagacgg 81001 acgggagatc gactgcattc ttcagacccc agacagtcgc gtcgtcggtg tcgaggtcaa 81061 agcctcggcg acagtgaacg tccatgattt ccgacacttg tcattcgcgc gtgaccgact 81121 cggcgacgaa ttcatcaccg gagttctctt ctacactggt gcccgggctt tgccgttcgg 81181 cgaccggttg atggctctac ccatcaatct cctctggaac ggacaatccg tctccagcct 81241 gtaggcgcat accgatcgcc atatttcaag agcaggttgg agcttctgcc cccaatcatc 81301 gtgcggcaac gatgggcggc tctagcgcta gtcgacgcgc tattcaacca gctcacaccg 81361 agctcccgcg cggccacata cccgcgaccg tgtgatgcaa gcaccccacc agctccgcgc 81421 atcacgcaac gaaccggtca aatcgtaggc ttccaaaatc tccatgatct cctcggcaga 81481 cttcacgtca ccccttttcg ggagctgaac aaccgacgcg gagccgtcgg ccgcggatgc 81541 cctggggcgg cggtccccaa acccgatatg gctaacgtca agcggtcgga tcacgggtcg 81601 agttgggcgg gggcgactcg gcacccggcg gcatgggctc cggtgtgcag gcgtcggtcc 81661 caaacggcga ctaccaggcc ggggtcgccg actgccaatg cgctggccag atgaacggcg 81721 tcggctccgc gtaaggcatg tgctcgggcg aggtggccgg cgtgctgttc aaccgtcgcg 81781 gtgagttcga ctgggcgggt ggcggcccag aagtcctccc agtcacgctc ggcgtcggcg 81841 agctcggatt cggttaggtc gtgattgcgg gccgctgcag cgagtgcggc gcggacttcg 81901 gggtaggcca ggcggctgga caatgcggcg tcgcagccgt cccatagagc ggacgccagc 81961 gagctccctg tctcggtggt gagaagtttg acgaaggcgc tggcgtcgaa gtagacgagc 82021 ggcacggtca gcgccgctgg tcgctgaccc ggtcagacac cggccgctgc ggtcggggcc 82081 tgggccgtcc cgcggctacg ggccgctgcg cggtcgcctt gccaatcacg ccttcggccg 82141 tgagacgctc caaggtgtct gtgctgtcca gcgcagcgag tcgtgcgatc ggaatcccac 82201 gttcggtgat gacgacctcg ccaccggccc gagctcgatc gagccaatcg ctgaggtgcg 82261 cgcgcaactc ggtcacggat acatccacac tttgaactgt acactcactg aaccgtgatt 82321 tgtacatatc actctgcgtg cggcaacgac gacgtgagag attgacctgc gcaagccgga 82381 ggcgaggtgg caacggccgg tacaccgatt cgtccgcggt gctggcgacg ccgaaacggt 82441 cgatgtcgtg gtgactggtc accttccgtc caagctgcat ccgaaggtgt tgcaacggaa 82501 ggtgtttgcc gtccgcgctg ggccttcggc gcagctggca tttgtggtca gctgcatggc 82561 gacggcagcg cctcggtggt gaacgccggg tttagcttgc agcggccgag caggctgcct 82621 cgttcctgct cggtgacagt tggcccgacg atgaccgcgc accgccgcca ccacgagata 82681 taacctagag gttatactgg tgcggaagcg ttggccgtga tcctgctccc gcaggtcgaa 82741 cggtggttct tcgcgctcaa cagggatgcg atggcctcgg tcaccggcgc catcgacctg 82801 ctcgaaatgg aggggccgac gttgggccgc ccggtggtcg acaaagtgaa cgactcaacg 82861 tttcacaaca tgaaggagct gcgccccgcc ggcaccagca tccggatcct gttcgccttc 82921 gacccggccc ggcaggcgat cctgctgctg ggcggtgaca aggcaggcaa ctggaaacgc 82981 tggtacgaca acaacattcc aatcgctgac cagcgctccg agaactggct ggcgagcgag 83041 cacggaggtg gatgaccatg gcccgcaact ggcgtgacat tcgcgccgat gccgtcgcgc 83101 agggccgcgt ggatctgcag cgggccgccg tggcacgcga ggagatgcgc gatgccgtcc 83161 tggcgcaccg cctggccgag atccgcaagg cgctaggcca cgcacgtcag gccgacgtcg 83221 cggcgctgat gggggtctct caggcccgtg tctccaagct ggagagcggc gacctgtccc 83281 acaccgaact cggcaccctg caggcctacg ttgccgccct gggcgggcac ctgcgcatcg 83341 tcgctgagtt cggcgaaaat actgtcgagc tgaccgcctg agctaactca cgcccacact 83401 tccggccggt ctcgatctcc caagccccag cacagctcgt gttcccaatc tgttcccaac 83461 cagatcctta gctatgcgca tgttcccaaa agtgttcccg cccatgaaaa cggcccccgg 83521 agtctcctcc gagggccatt tcgccggtag cggggacagg attcgatgaa ccgccccggc 83581 atgtccggag actccagttc ttggaaagga tggggtcatg tcaggtggtt catcgaggag 83641 gtacccgccg gagctgcgtg agcgggcggt gcggatggtc gcagagatcc gcggtcagca 83701 cgattcggag tgggcagcga tcagtgaggt cgcccgtcta cttggtgttg gctgcgcgga 83761 gacggtgcgt aagtgggtgc gccaggcgca ggtcgatgcc ggcgcacggc ccgggaccac 83821 gaccgaagaa tccgctgagc tgaagcgctt gcggcgggac aacgccgaat tgcgaagggc 83881 gaacgcgatt ttaaagaccg cgtcggcttt cttcgcggcc gagctcgacc ggccagcacg 83941 ctaattaccc ggttcatcgc cgatcatcag ggccaccgcg agggccccga tggtttgcgg 84001 tggggtgtcg agtcgatctg cacacagctg accgagctgg gtgtgccgat cgccccatcg 84061 acctactacg accacatcaa ccgggagccc agccgccgcg agctgcgcga tggcgaactc 84121 aaggagcaca tcagccgcgt ccacgccgcc aactacggtg tttacggtgc ccgcaaagtg 84181 tggctaaccc tgaaccgtga gggcatcgag gtggccagat gcaccgtcga acggctgatg 84241 accaaactcg gcctgtccgg gaccacccgc ggcaaagccc gcaggaccac gatcgctgat 84301 ccggccacag cccgtcccgc cgatctcgtc cagcgccgct tcggaccacc agcacctaac 84361 cggctgtggg tagcagacct cacctatgtg tcgacctggg cagggttcgc ctacgtggcc 84421 tttgtcaccg acgcctacgc tcgcaggatc ctgggctggc gggtcgcttc cacgatggcc 84481 acctccatgg tcctcgacgc gatcgagcaa gccatctgga cccgccaaca agaaggcgta 84541 ctcgacctga aagacgttat ccaccatacg gataggggat ctcagtacac atcgatccgg 84601 ttcagcgagc ggctcgccga ggcaggcatc caaccgtcgg tcggagcggt cggaagctcc 84661 tatgacaatg cactagccga gacgatcaac ggcctataca agaccgagct gatcaaaccc 84721 ggcaagccct ggcggtccat cgaggatgtc gagttggcca ccgcgcgctg ggtcgactgg 84781 ttcaaccatc gccgcctcta ccagtactgc ggcgacgtcc cgccggtcga actcgaggct 84841 gcctactacg ctcaacgcca gagaccagcc gccggctgag gtctcagatc agagagtctc 84901 cggactcacc ggggcggttc acgaacctgc gacctctggg ttatgagcta accagtcgca 84961 atctctccca tcgcggtcgg tctcatacgt ccagatcagc ctctattccg ccgtccagcc 85021 tgttccgccg cgtcgcggtt gtacggattt gaaccgcccc ggcatgtccg gagactccag 85081 ttcttggaaa ggatggggtc atgtcaggtg gttcatcgag gaggtacccg ccggagctgc 85141 gtgagcgggc ggtgcggatg gtcgcagaga tccgcggtca gcacgattcg gagtgggcag 85201 cgatcagtga ggtcgcccgt ctacttggtg ttggctgcgc ggagacggtg cgtaagtggg 85261 tgcgccaggc gcaggtcgat gccggcgcac ggcccgggac cacgaccgaa gaatccgctg 85321 agctgaagcg cttgcggcgg gacaacgccg aattgcgaag ggcgaacgcg attttaaaga 85381 ccgcgtcggc tttcttcgcg gccgagctcg accggccagc acgctaatta cccggttcat 85441 cgccgatcat cagggccacc gcgagggccc cgatggtttg cggtggggtg tcgagtcgat 85501 ctgcacacag ctgaccgagc tgggtgtgcc gatcgcccca tcgacctact acgaccacat 85561 caaccgggag cccagccgcc gcgagctgcg cgatggcgaa ctcaaggagc acatcagccg 85621 cgtccacgcc gccaactacg gtgtttacgg tgcccgcaaa gtgtggctaa ccctgaaccg 85681 tgagggcatc gaggtggcca gatgcaccgt cgaacggctg atgaccaaac tcggcctgtc 85741 cgggaccacc cgcggcaaag cccgcaggac cacgatcgct gatccggcca cagcccgtcc 85801 cgccgatctc gtccagcgcc gcttcggacc accagcacct aaccggctgt gggtagcaga 85861 cctcacctat gtgtcgacct gggcagggtt cgcctacgtg gcctttgtca ccgacgccta 85921 cgctcgcagg atcctgggct ggcgggtcgc ttccacgatg gccacctcca tggtcctcga 85981 cgcgatcgag caagccatct ggacccgcca acaagaaggc gtactcgacc tgaaagacgt 86041 tatccaccat acggataggg gatctcagta cacatcgatc cggttcagcg agcggctcgc 86101 cgaggcaggc atccaaccgt cggtcggagc ggtcggaagc tcctatgaca atgcactagc 86161 cgagacgatc aacggcctat acaagaccga gctgatcaaa cccggcaagc cctggcggtc 86221 catcgaggat gtcgagttgg ccaccgcgcg ctgggtcgac tggttcaacc atcgccgcct 86281 ctaccagtac tgcggcgacg tcccgccggt cgaactcgag gctgcctact acgctcaacg 86341 ccagagacca gccgccggct gaggtctcag atcagagagt ctccggactc accggggcgg 86401 ttcaattcgt ttcggcctgt tctgttccca aatccgttcc caacacagca atcagcagca 86461 atcccaggcc gaaatcggtc agactcttgg tggacctaca gcacctcgcc tccatgtggt 86521 cgcggagcta gtgagggtcc atcggcagca ccacttaggg cgcctccgtt gtcatcatgg 86581 tcgataagcg gtagcgttta cggtagtaga accggaagtt gcggaggaac cacgatggcg 86641 gtcaccctgg accgggcggt cgaggccagc gagatcgtcg atgccctgaa acccttcggc 86701 gtcacccagg tcgacgtcgc cgcggtcata caggtgtccg atcgggcggt acgcgggtgg 86761 cggaccggcg acatccgccc tgagcggtac gaccggctgg cgcagcttcg tgacctcgtc 86821 ctcctgctct cggattcgct taccccccga ggtgtcggcc agtggctgca cgccaaaaac 86881 cggctcctcg acgggcagcg cccggttgac ctgctcgcca aggatcgcta cgaggatgtg 86941 cgaagcgcgg cggagtcatt tatcgacggc gcctacgtgt gaagcttgcc gacgcgatcg 87001 ccaccgcacc gcggcgaacg ctcaaaggca cctactggca ccaaggcccc acacgtcacc 87061 ctgtgacctc ctgcgccgac cccgcccgag gtcctggccg ttaccaccga acgggcgagc 87121 cgggagtctg gtacgcatcg aacaaagagc aaggtgcatg ggcggagttg ttccgccact 87181 tcgtcgatga cggggtcgat ccattcgagg tccgtcgccg cgtcggtcga gtggcggtca 87241 cactccaggt actcgacctc acagacgaga ggactcgatc ccatctaggt gtggacgaaa 87301 cagatcttct gtccgacgac tacaccacca cccaggccat cgccgccgcc cgcgatgcca 87361 acttcgacgc cgtactggcc ccggcggcgg cgctccccgg ttgtcaaaca cttgccgtgt 87421 tcgttcacgc actgcccaac atcgagcccg agcgatccga ggtccgtcaa ccgcctccgc 87481 ggctcgccaa cctactcccg ctgatccgtc cgcacgaaca catgcccgac tccgtgcgca 87541 gattgcttgc aacgctgaca cgtgcaggag ccgaagcaat ccggcgccga cgacgttaaa 87601 ggcttcgaga ccggacgggc tgtaggttcc tcaactgtgt ggcggatggt ctgagcactt 87661 aacgcttcgt tgaccaaagc cccacttgat gcgaggacgc gatcagacaa cggaatggcc 87721 tagccgccgt cgcggtggct ttgcgcgact ggggcggctc acggaatggt cgtcgttggc 87781 acctctgctg tcgggcgtaa tgcaaaggga atcaatgtca ggtgaatctc gcgttcggga 87841 tcaccgtcgg cgtgcatggt gaactcgtac tggtctgcac cggcccgatg tgcggggcag 87901 cgcttatgat tcgggtgctc tttgatcttg gcgatggcgt tatcgatgac cgcggtcacg 87961 tctttgttgc ggataaagag caagatcgcg gccttggtgt cgcgccacac aaggtagccg 88021 aatagctgct tcagcacatc gtccatggtt cttgggcccg accacacttt gcattcgcca 88081 atgaagatgt tgcggtcgtc gacgcgaatg agaatgtcgg tcttgcctgc gccgttgaag 88141 agttcgcccc cggcatcgcc ttcaaactgt gcgttgaggc cgacgagcag catgtctcgg 88201 atttcttccc cgtcgagctt ggcggcgaca gatggggtgc gctccaacgc gttccgctgg 88261 ttacggagca cccgaagtgc ggactggtag tcctcatcct gcattgcagg ctccggcttg 88321 aatgctgccc tcgcgcccgc tgggcggtgt ggccgcggac gcacgctttt ccgactgatc 88381 ggagctgcgt atgtgtcggc gtccttcctg cggcgtacag ggaagccgat ctcggcctgg 88441 aggtttcggg tcgctaagag ctgctcacgg cgcctcgcca ccatgcccgg tagctcgttg 88501 cgcagtcctt ggttgtgcaa gtcgatctgc cggcgcgacc aaccgaggta cttctcaata 88561 ttcgcgatct gcttatgaaa cgccgcgttg atcgccgcgg cgtcattcga cagattgtcg 88621 atcgccaggt ggatttcgtg accttgtagc cgcagtacct gcggcggcat ggtcgtgaac 88681 tggtccgggc gaaggttaaa gatgtcctta tgcccctcga agggcaccac gagaacgagc 88741 ctcgtcacgc gtcgggtgcg ctgttcgccc caatcccggt actgctggtc gacctcggtg 88801 gctggcagca tgaaagcgtc gtcgacgcgc agatcggggc attcgaccga acccaattcg 88861 acgagctgtt cgacgacgtc atcaacgggc gtgttcagca ggtcgtcggc gtcccagctc 88921 tgaagacgct gcgccgtggc ttggctcgcc tttccgagaa atccggctaa ggagccagcg 88981 agatcgttga ggcgcccctt ggaaaacagc tgaacatact ccacttaccc gaagatagtg 89041 ctcatccccg acgcggctac ggaggcgttt cggcggcgtg ccgcgatgca atgcagccag 89101 cggagccacc gggccgtagc cgacgtcgcg tcgtgggtgg cgacggggtt ctccggggtg 89161 ccggaatcct tcgacgagct tgtcgggggt catgattact gttctcgata tgaacggatt 89221 caaggatgcg aggcccgatc gtcttccgct ttcggcatcg gtttgggata tcgcccagcg 89281 atacaacaag ggcggaccta ccgtcactga ggcgctatac gaggcgctga aggaactcga 89341 ggcccaagtc atcgctctgc agcgaagcga gggtaagggc ctgctcagcc gcctgagctg 89401 aacgactaga ggattgggga aggggccccc ggggaatgga tcatcctact gagcgggaat 89461 gggccagcat cgccgaacat acacgcgcct ccaacttcac cggcgacctg ttacgaatgc 89521 cgccttaccc gctgatcctc accctccgaa cgctggtggg gtctgccgag gtggtcactg 89581 catcacatac cctcttcctg tcggcggcaa ctgaatactg accagagcgc ggcaaggtgg 89641 gttctagtca acgtcgcaac aattgatggt ctggtgaggt tagcagcgcg gtgaaaagtt 89701 cagcgggact gcggtgcccg aggacttggc ggggtcggtt attgatctcg tattcgacag 89761 cccgcagatg gtcgggcgtg taggtgctga ggctggtgcc ctttgggaag tattgccgta 89821 gcagaccgtt ggagttctcg ttgctggctc gctgccacgg tgagcgggag tcgcaaaagt 89881 agaccggcgc gcccaggtcg gcggtgatgt cgatgtgccg ggccatttcg atgccctgat 89941 cccacgtgat ggaccggacc agcgtcaccg gcaagtcgct catggtctcg gtgatcgcga 90001 tgcgcaggca gtaagcgtcg tgggtcggca ggtgcagcag ccgaatcaga cgtgtctgtc 90061 gctcgacgag ggtgccaatc gccgagccct ggttcttacc aacgatgaga tctccttccc 90121 agtggccagg ctcggagcgg tcggcgggat cgaacggccg ctggtgaatc gacaacatcg 90181 gctgggcgaa gcgcgggcgg cgacggccag gacgcagatg ggcgcggcga tgagttcgtc 90241 ccgtgcgcag agggccacgg tgtggcgact tgacctgcgg cggccggatc aatcgtgatt 90301 gaggctgata gacggcctga tagatgcttt cgtggcacaa ccacatcgac cggtcatcgg 90361 ggtatttccg tcgcagatgc cgggcgatct gttgcgggct ccaccgctgg gccagcagct 90421 cggcgatcag ctcacaaagg tcggggtttt tgtcgatccg acgccggtga cggcggactc 90481 ggcgttgaac cgcccagcga tgcgcttcga acggccggta ctggccatcg cggcgactgt 90541 tgcggcgtag ctcccgcgac accgtcgagg gtgcccgtcc gagctggtcg gcgatcttgc 90601 ggatacttag gcccgagcgg cgcagatcgg cgatgttgat ccgctcctcc tcggacagat 90661 agcgactact aatttggcgc acagccaaac gatcgagcgc gggcacgaat ccgacggctt 90721 cgccacgccg ataggtcttg tatccccgcg cccaattgtt tgctgcagtc cgggatactc 90781 caacttcacg acccgctgcc gagatggacc agccccgagc ccgcagctcc ataaaccgtt 90841 gacgcttggc cgactgtggg cgccggcccg gacccttttt cacgcgacga gacgatgaca 90901 acacaacctc cagaacctag agatgtgttg cgacaccgcc tagaaaccac cttgccgaca 90961 cctgatcagt tttcggttgc cgctgacaca atgaacatgg cccgcttcac ccgttcagcg 91021 tcacgtggat aagcggcccg tagcgcgtcc cagtcggttt cggagtagtc gggccgttgt 91081 acaggggcat ccggcgcggc cggtggcggc atcttgatgc cgccaccggc cgcgtcacgg 91141 ttcgcggttg gcgctcgcct gacgacggtg ctgctcccgt tcctgagcac gctgctttct 91201 agccttgcgg tctccctgct ttcccatctc ccggtcctcc cggcgggtca cgatagccgc 91261 gcactccgac atacctggcg cggcgcgggg cgctgcgaac cggatgggcg ccaccaccga 91321 taaccattgc gcgttgcggc agccttcgca ttagcaatgc tggcgcgccg ctcgacgcct 91381 cggctatcac ctcacctgac caccgcgcgc atcaccgacg agacctcatc atcgcgcccg 91441 ctctcgcaaa caccacgccc gccaaacggg gctggcccga gacgatttca gaggccccta 91501 cagaccgatc cgcacgcccg aaacccgggt taccgctaag cagcccagga cagcagccgc 91561 agtcctgatc ggcgaagact gacgttcaga ccgcaagcaa gctaaatagc aagccaagca 91621 attagcaaga ctaatgttcc caaatccgtt cccatcgggc atgaaaatga ccccagaggt 91681 cgcacctctg gggtcatttc cgctggtagc ggggacagga ttcgaacctg cgacctctgg 91741 gttatgagcc cagcgagcta ccgagctgct ccaccccgcg tcggtaaatg ccaggctacc 91801 gaacacgcac gaagctcgcc aaatcgcggg tgccggagta cgaccgccca gatcagcgga 91861 gctcgggcat acagctgcgc cgtacgcgtc gatgcgatga tgattccgca gccgctcagc 91921 cagctcggtg acctggcgcg tcgcccaggc cgcagggttc tctgttcccc gaaaacggcc 91981 gcaccgtcga tctcaaacgc aactgtcgcc tcgccggccg cgcccggcct tgagctgtcc 92041 accgggatcg cgttggcgtt cccgcgcggt cccttcgtcc cggcagccgc ggcgtgggag 92101 ctccaggaag ctaccagcgg gaagttccag ctcggtctgg gcacgcaggt tcgcaagaat 92161 gtggtgcacc gatacggtat ggccttccac cgtcccggtc cgcggctgcg ctacctgctg 92221 gccgtgaagg cgtgcttcgc cgttttccaa accgggacac cggatcacca cggcgagttc 92281 gacaatcccg acttcatcac tgcccaatgg agcccggcgc gcattgaccc ccccggtccc 92341 agccccgctg ggccgcggtg aatccgtgga tgcggcgagg tggccgacgg ggtgtggggc 92401 gaggccgggt tcgaggggac gaccacgcgg atccgggagc cgacgagcac ccgtgagcag 92461 acgcagaagt ccccgatttc cggtgaaatc ggcgacttct gcgtctgctc gccgcgagcg 92521 ccccgactga ctacccggcg tcgttgaact tggtgatggc ctcatcaagt cgctgcagcg 92581 ccgacccgta ggcggcgaag tcgcccttct tctgcgcatc ccgcgccgcg ccgatggcag 92641 cctggatctc ctgcagcgca gcaactttgg ccggcgataa ggtgaccgcc ccgacgggaa 92701 ccgggggcgc cgcagtcacc ggcggcggtt ggggtccact ggcaggcggc ggtggattcg 92761 cagcgggact cggtggtacc gctgcctccg tgggcgcgat cccggtagcc gtcgcaccgg 92821 ccccgggccc gaacaagccg gtgagcgcat cccgcaccgt ggggccgtat cccaccttgt 92881 cgttgtacat catcgccacc cggatcagcc gcgggtagga cgaagcagcg tcgctggctc 92941 ccggggatgc atagaccggt tcgacgtaga gcagtccgcc ccgggccacc gggagcgtga 93001 gcaagttgcc ccagcggatg cggttttggt tgtcgcgtcc gatgacaccg aggtcctggg 93061 acaccgccgg atcggtggtg atcgcgttgt tggccaactt gggcccgttg acctggcctg 93121 ggatggtcaa caccgtgaga ttgccgtagg tcgcgggatc ggaactggcg ctgatgtagg 93181 cggccagata gtcacgcttg aatctgttca tcgcgctgat caactgatat gaggctgaat 93241 tatcgtcctt agcaatgttt ttcgcgacga tgtaatacgg cggctgataa ctgctggcgg 93301 tcggattcgg gtccagcggc acgtcccaga aatccgatgt ggagaagaac gtcaccggat 93361 cattgacgtg gtatttggcc aacaacatgc gctgcacctt gaacaggtcc tcgggatacc 93421 gcaggtgctc ggcaagctcc ggcgcaatgt cgctcttagg ctttaccgtg ccggggaaga 93481 cctgcatcca ggccttgagc accggatcct tttcgtcctg ttggtacagc gtgaccgttc 93541 cgtcgtaggc atccacagtg gccttcaccg aattgcggat gtaggaaacc ttcttgtccg 93601 ggaccaaccg gttgaacgcc acctcgttgg agtccgcggt cgccgaggac agcgaggtga 93661 gctcggagta cgggtaattg tccaacgtgg tgtagccgtc gacgatccac accagtcgct 93721 tgttgacgat cgcgggatac acagcgctgt ctgtcgtcag ccacggcgcg accgcctcca 93781 cccgctgcgc cggatcgcgg ttgaacaaga tcttgctgtt ggagccaatc acattggaga 93841 acaaaaagtt tcgctccgcg aacttcgcag cgaacacgct acgggctaac caaccaccga 93901 gcgggactcc accgcttccg gtgtaggtgt atctcttggt gtcgatgtta gtttcgtagt 93961 cgtattcgcg gtcgtcgcca ttgcgtccaa cgatcgcata gtccgcggac gtgttagaga 94021 tcaccggacc gaagtagatc cgcggctgat ccagtggcgc cggcccatca gacaccacgg 94081 tgccattggc cccgacgacg ttgaccaaga attcggggta accgccattt tgattcgggt 94141 cgttggcgat accgcgcacg gtgttggccg gtgaggcgat gaacccgttc ccgtgggtgt 94201 acacggtatg ccggttgatc cagtcccgtt ggttgtcgat caaccggtcc gggttgagtt 94261 cgcgggccgc gacgacgtag tcgcgcaggt taccgttgcg gtcgaggtag cggtcgatcg 94321 acagctggtc cgggaaatag tagaagttct tgccctgctg gaactgggtg aacgccgggc 94381 taacgattgt cgggtcgagt agccggatgt tcgaggtagt cgcgcggtcg gcagcgacct 94441 gttgcgcggt agccgggcta tcaccgctgt aattgcgata ggtcaccaca tcagacgtca 94501 ggccataggc ttgccgagtt gcggtgatac ttcggctgat atattcgctc tctttttgcg 94561 cagcgttggg tttgacgctg atttgctcga cgatcaacgg ccagccggcg ccgacaatca 94621 gcgacgacag cagcaacaac accaggccga tcgccggaat ccgcaagtcc cgcagggcga 94681 tcgccgagaa cactgcggcc gcgcaaatca acgcaatcgc catcagaatc agcttcgccg 94741 gcaggacggc gttgatatcg gtgtacccgg caccggtgaa cggcttgccg ccacgcgtgt 94801 gcgacagcag ctcataccga tccagccaat aagcaacggc tttaagtaac accagtaccc 94861 cgaccaggct aaccaactgg acgcgcgccg agcggctcag cgcaccggtg cgtccggata 94921 gccgaatgcc accgaagata tagtgcgcca ccagattcgc cacgaatgcc agaaataccg 94981 aaacgagcat gtagctgagc atcagccggt agaacggcaa ctcgaacgcg tagaagccga 95041 ggtcccgccc gaactgcgga tccctaaccc caaagtcacc gccgtgcagg aacagctgga 95101 tccgagccca gtagctttgg gcgacgatgc cggccagcaa gccgatcgcc gcggggattc 95161 cgatgccgac tagccgcagg cgtgccagca cgacggcgcg ataccgtgca accggatcgt 95221 tgtcggcatc cgggacgaac accgggcgag tgcggtaggc caaggcgagc ccgccgaaca 95281 cgatgccgcc gaccaccacc ccggcaacca agcacaccac gatgcgggta gccagcatgg 95341 tggtgaacac tgagcggtag ccaagctcac caaaccacag ccagtcgacg taagcgtcga 95401 tcaaacgcgg gccagcgagc agcagcacga tcacacccag tgcgatcatg atcagaatcc 95461 ggctgcgccg tgtcagtttc ggcatccttg cggcggaccg cattcccact agctacgctc 95521 cctgatcgtt ctggctggtt gagactttct cgacggtcat aactctacgc accgcaacca 95581 tccgcagcag ccggcgcgag ctagcagctc ggcgtcggcg agcccgacgt catcgcgtgc 95641 agcgcgtcca ccgcctggct aagcgtctcg accttcacca acttcaaacc gggcgggctg 95701 tcggaacttg cctcgtagca gttcttcgcg ggcaccagaa acaccgtcgc gccggccgct 95761 cgagcagcgg ccatcttgtg ggtgatgcca ccgatctggc ccaccttgcc atcgacggcg 95821 atcgtgccgg tgcctgcgac gaacgtcgac ccaaccaggt ggccactggt gagcttgtcg 95881 acgacggcca gactgaacat cagtccggcc gaagggccgc cgacgttggc gaggtggaag 95941 tccacggcaa acggcgccca cggcgcgtcc accacctcta tgcccaggac gccttggtcg 96001 cgatccttat tcttgcccag cgtgatctgc gcgatgccgg gcggctcgtt cttgcggcgg 96061 aagtcgatcg tcacctcctg gcccggtttc gtgttcttca acagcgcggt gaactggtcg 96121 aggttgccca ccggagtgcc gtcgacggcg tcgatggcgt caccggcctg cagcttgtcc 96181 accgatggcc ctggatccat gaccgaggcg acggtgactg ctttcggata cttcaggtac 96241 cccagagcgg cgtactcagc ggcggcctcg gagcgcttga aatcagcggc gttgtcattt 96301 tcgatctctt cccgcgactt gcccggaggg tagacgaggt cgcgtggcat caactgttct 96361 tgacccgaaa gccacagggc cagggcttca cccagggtta gaccgtcgcg ctgggagacc 96421 gtcgtcatgt tgaggtgacc tgacgtcggg taggtctggg tgcccacgat ctggaccacc 96481 tgcttgccgt ctatctcgcc gagcgtgtcg aacgttgggc cgggtcccag cgccacaaac 96541 ggcacggtta ccacggcgag caacacgccg aataccacga tcggcaccag cgcgaccatc 96601 aaggtcaata tccgcctatt cacgccgcat acactagacg gacctggccg ggctggttca 96661 gctgcgagcg tgaccgctga tcgcaccttc tgttcccgcg gtgagtaccg gtgaggtcat 96721 gggtgacctg cctttcggct tctcttccgg agacgacccc ccggaagatc cgtctgggcg 96781 cgataagcgc gggaaggacg gtgccgattc cggatcgggc gccaatccgt tgggcgcgtt 96841 cggcatcggt ggagaattca acatggccga cctggggcaa atcttcaccc gcctaggaga 96901 gatgttcggc ggcgtcggca ccgcgatggc cgcgggcaaa acctcaggac cggtcaacta 96961 cgacttggcc cggcaggtcg cgtcgagctc gatcgggttc atcgcgccca tcccggcggc 97021 cacgaactcg gcgatcgccg acgcggtgca tctggccgac acctggcttg acggggcaac 97081 ctcgctaccc gctggcgcca ccaaggcggt gggttggagc cccaccgact gggtcgacaa 97141 caccttggct acctggaaac ggctgtgcga tcccatggcc cagcagatct ccacggtctg 97201 ggcgtcgtcg ctgccggaag aggccaagag catggccggc ccgctgctgt cgatcatgtc 97261 gcagatgggc ggcatagcgt ttggttcgca actgggccaa gcgctgggcc ggctgtcccg 97321 tgaggtgctg acgtctaccg acatcggtct accgctgggg cccaaggggg tggccgcaat 97381 actgcccggc gccgtcgaat cgtttgccgc cggactcgag caaccgcgca gcgagattct 97441 gacgttcctg gccacccgtg aggccgcaca tcaccgcctg ttcagccacg ttccctggct 97501 ggccagtcaa ctgctcggcg ccgtcgaggc ctacgccatg ggcatgaaga tcgatatgac 97561 cggaatcgag gagctggccc gcgatatcaa tccgacgtcg ctggccgatc ccgccgccat 97621 ggaacagctg ctgagccagg gagtattcga gcccaaggca acgccggccc agacgcaggc 97681 attggaacga ctcgaaacac tgctcgccct gatcgaaggc tgggtgcaga ccgtggtgac 97741 tgcggcgctg ggcgagcgaa ttccgggtga ggcagcgctc agcgagacgc tgcgccgacg 97801 ccgagccagt ggcggccccg ccgaacagac ctttgcgacg ttggtcgggc tggagctgcg 97861 gccacgcaaa ctgcgggagg ccggagcgct gtgggagcgc ctcacccggg ccgtcggcat 97921 ggacgcccgc gacgccgtct ggcagcaccc ggacctgctg cccgccactg acgatctcga 97981 cgacccggcc gcctttatcg accgtgtcat cggcggcgac accagcggta tcgacgaagc 98041 gatcgccgaa ctcgagcggg accagcaggc ccgcggcgcc gacgactccg gccacgatgg 98101 cggtcctgtg gataactgag cggtgtgtct gctcgcagtg tggcaccgtc tcaggtcatg 98161 cggcgggctg cgtctgctct gtattcgttg aatcctgcga tgccggtgct gctaagaccc 98221 gacggtgccg tgcaagtggg ctgggatcct cgtcgggctg tgctcgtccg tccaccgcgt 98281 ggattaaccg cgacaggttt ggccgcgctg ctgcggtcca tgcgatcacc gataccaatc 98341 accgagttgc agcgccaagc cgccgagcgt ggattggttg acggtgacgc catggcgaac 98401 cttgtcgcgc aactggttgg cgcgggtgta gcgacccccc tagccaaccc cggaaacctg 98461 gattcccggc gtcgcgccgc gtccatccgg gtccacggtc gcgggccgtt gtcagacctg 98521 ctcgtccagg cgctgcgctg ctccggtgcc cggatcaggc acagcagcca accacatgcg 98581 gcggtgactc ccgcgggcgt ggatctggtg gtgttgtcgg actatctggt ggccgatccg 98641 cacatggtgc gcgatctgca caccgagaga gttccgcatc ttcccgttcg ggttcgtgac 98701 ggcaccggga tggtcgggcc cctggtggtc cccggcgtga ccagctgtct cggttgcgct 98761 gacctgcatc gcagcgaccg cgacgccgcg tggccggcca tcgccgccca attgcgggac 98821 accgtcgggg tggccgaccg ggccacgttg ttagcgacgg cggcgctggc gctcagccaa 98881 gtgaaccggg tgatcgccgc cgtgcgtgga caggaggcga cccctgagcc cccgtcggcg 98941 ctgaacacca ccttggagtt cgatctcaac gctggctcta tcgtggcgcg acaatggacc 99001 aggcatccgc ggtgtttttg ttgacgttac gtctaaccca gtcgtccctg ctccggcacg 99061 ttggtcgaga ttgacgcata ggctctggcc aaggtgtcga gcacgtcctc tgtcagggtg 99121 cgctcgttgc ggtgcttgtc cagcgtttcg atgatcgctc tgaacagggc gtcggcagcg 99181 tcgtgctgcg ttgatcttgc tgacatggtt tcttgcggtc caccctcctg cacatttcac 99241 tgatgcggcc aacaccacaa cgcttgtcgg cgcttgtcga cgcttgtcga ctcggggcaa 99301 gctcaaccgt ccgcacccag gcagttgtta ccagatcaac accccgaccg gataaccgtc 99361 atggatgatg ggagtgtgtc agatatcaaa cggggccgcg ccgcgcgcaa tgcgaagctg 99421 gccagcatcc cggtcggctt cgccggtcgg gcggcgctcg ggctcggcaa gcgactgacc 99481 ggtaagtcaa aagacgaggt taccgccgag ctgatggaga aggccgccaa tcagttgttt 99541 accgtcctcg gcgaactcaa gggtggcgcg atgaaggtcg gccaggcgct gtcggtgatg 99601 gaggccgcca ttcccgacga gttcggcgaa ccctaccggg aagcactgac caagctgcag 99661 aaggacgccc caccgctgcc cgccagtaag gtgcaccggg tactcgacgg acagctgggc 99721 accaaatggc gggagcggtt cagctcgttc aacgacaccc cagtggcatc tgccagcatc 99781 ggccaggtgc acaaagcaat ctggtcggac ggccgagaag tggccgtcaa gatccagtat 99841 cccggcgccg acgaggcgct gcgcgcggac ctcaagacca tgcagcgcat ggtcggcgtg 99901 ctcaaacagc tctcacccgg cgccgacgtc caaggggtgg tcgacgaact ggttgaacgc 99961 accgaaatgg aactcgacta ccggctggag gccgccaacc agcgcgcctt cgccaaggcg 100021 taccacgacc acccgcgctt ccaggtgcct cacgtcgtgg caagcgcacc gaaggtggtg 100081 atccaggagt ggatcgaagg tgtgccgatg gcagagatca tccgtcacgg gaccaccgag 100141 cagcgtgatc tgatcggtac gctgctcgcc gagctcacct tcgacgcacc acggcggctg 100201 gggttgatgc acggcgacgc ccaccccggt aatttcatgc tgctgcccga cggccggatg 100261 ggcatcatcg acttcggtgc cgtggcaccg atgcccggcg gcttcccgat agagctcggg 100321 atgacgattc gactggcccg cgagaagaac tacgacctcc tgttgccgac gatggagaag 100381 gccgggttga tccagcgagg acgacaggtg tcggttcgcg agatcgacga gatgctgcgc 100441 caatacgtcg agcccatcca ggtcgaggtc ttccactaca cccgcaagtg gttacagaaa 100501 atgaccgtca gtcagatcga ccgctcggtt gcgcagatca gaacggcgcg ccagatggac 100561 ctgccggcca agctcgcgat tccgatgcgg gttatcgcat cggtgggcgc gatcctatgc 100621 cagctggacg cgcatgtgcc gatcaaggcc ctgtcggagg agctgatccc gggtttcgcc 100681 gagcccgacg cgatcgtcgt ctgagccggc tcgcgccggc gggcgcacca tcgcgggcta 100741 tgcaacagca tccttgcgcg gacgtccgcg cggacgcttg tgactcacga tcgagccttg 100801 gtcgaatatc tcaccacccc aaacgcccca gggttcagcc cgctgaagcg ccgcggccaa 100861 gcactgccgc ctgatcgggc agctcacaca cagtgtcttg gctacctcga gaccggccgg 100921 ggtatcggcg aaccacagat cgggatcacc gacgtggcac ggcaaaaccg gcaatctttg 100981 tctgggggtc tgtctgggga ctgtcagtac cgacacgtcc tgtttcacct gcttcctggt 101041 ctggtggcgg ttcttcgaaa gtgatccgga ccagggatgc tgcggtgggc agatgtcccg 101101 aaagtttggc cacggatcct gtgacttcgg gtccgtggcc atctggcgaa acggggctga 101161 ttacgtagcg cttacgtaga gccccgctcc acggactcgt cagtcgcggc ggcgacacgg 101221 ttcttgctat ggggggttcc cgcggttggc accgcggcag ccgcgccgac accaaatgcg 101281 ttgttgtcaa tcaccgcggc cgccctcctc tcgtgtcgcg cgcggttgcc agccccccaa 101341 tgccatctcc aggctggcag cagaatgcga cctggaggtt aaccggtggc agcagctgac 101401 cacaaccgat tttctgacct gcgcgtttgc cggtacaggc ccggttcagg tccgaccgcg 101461 aaccagctgc agcacgtccg atccgtattg ttccagcttg cgggcaccga tgccggggat 101521 cgcgatcagc gccgcgtcgt cggtaggtag cagctcggcg atcgcgatca gggtgttgtc 101581 ggtgaaaacg acataggcgg ggacgttctg ttccttggcg gtgctcagac gccaggactt 101641 gagctgcaac aacaactcct cgtcgacgtc ggctgcacac gtctcacacc gccgcagcat 101701 gacggccgcc gaagtgttca gctcgttgtt acagatccgg cagcgcgctg cggcgccccg 101761 gttgcgtcgg gatgtgcccg gcaccggatc ggcgcgcgtc tgcggcgcaa tgccgttgag 101821 gaaccgcgag ggcttgcggc tctggcgccc gcccggggac cgtgatagcg cccagctgag 101881 cgccaaatgg actcgggccc gtgtgattcc gacgtagagc agccgacgct cttcctctac 101941 gggctcgcta ttggggccgt gtgccagcgc atgtgagatg ggcagcgtgc cgtcagccaa 102001 tccgaccagg aacaccgcgt cccattccag tcccttggcg gcgtgcagtg aggccagcgt 102061 gacgccctgc accaccggtg ggtgccgcgc ctccgcccgc cggcgtagct cggcaagcag 102121 gcctggcagc tgcagtgcgg gacgctgcgc cagctcgtcg tcgaccagct cggccagcgc 102181 ggtgagcgct tcccagcgtt ccctggcgcg ggtgccgacc ggcggttgtg ccgtcagccc 102241 cagtggtgcg agcaccgcgc gaaccacgtc ggacaacgcg gcatcggtat cacgttcgga 102301 cacacgctgt aaggcaagca acgcctgctt gatttcctga cggttgaaaa acccctcgcc 102361 accgcgaacc tgataggcga tacccgcctg ggtcaacgcc tcttcataaa cctctgactg 102421 cgcattgact cggtagagaa tggctacctc ggatggcgga gtgcccgatg cgattaaccg 102481 ggcgattgac gccgccaccg tggcagcctc ggcgggctcg tcggaatgct catggaacga 102541 cgggaccgga cccggctcac gctggccgga caaccgtagc ttgctgccgg caacacggcc 102601 ccgggcggcg gcgatcaccc ggttagccaa tgacaccacc tgcggagttg accggtaatc 102661 acgctccagc cgcaccaccg cggcgtccgg gaaccgccgc gagaagtcga gtaggaaacg 102721 aggcgaagcc ccggtaaacg agtagatggt ctggttggcg tcgccgacga cggtcaggtc 102781 gtcccgatca cccaaccagg ccgagagcac ccgctgctgc aggggggtga cgtcctggta 102841 ctcgtccacg acgaaacacc ggtaccggtc ctggaactcc tcggccaccg cggcgtcgtt 102901 ttcaatcgcg gccgcggtgt gcagcaacag gtcgtcgaag tcaagtaagg tgacgccgtc 102961 gccgcgggcc ttgagcgcct cgtattcgga gtagacagcc gcgatttgcg cggcgtccaa 103021 cggggggtct cggcgtgcgg ccgccactgc ggtcacatac tcctcggggc cgatcaggga 103081 cgccttggcc cactcgatct cgccggccag gtcacgcaca tcatcggtgc tggcgtgcag 103141 cctggtgcgg ctggcggcgc gggccaccac ggcgaacttg ctgtccagca gctgccagcc 103201 ggtgtcagcg attacgcgcg accagaagta ccgcagctgg cgatacgcgg ccgcgtgaaa 103261 ggtcagcgcc tgcacagcgc cgacgcccga accggtccgt gccgcggcgt cgagtgcgcg 103321 caaccggctg cgcatttcgc ccgccgcgcg ctgggtgaat gtcacagcca gcacctgccc 103381 ggcggcgacg tgaccgctcg cgaccagcga agcgatccgg tgagtgatgg tgcgggtctt 103441 gccggttccg gcaccggcca gcacgcacac cggtccacgc ggagccagta cggcttcgcg 103501 ctgctggtcg tccagcccgg caatcaatgg gtcgctggct atcgacatga cgtccatctt 103561 ggcagcggta gatgacagac cgggcgtgtc gccacgccgt ggggcgtgcg acatgaacaa 103621 ctgccgagcc gccacaccgc ccgggtcgtc gccgcgctag gttagcgtgt catgatcacc 103681 gctgcgctca ccatctatac gacatcatgg tgtggctatt gccttcgact caaaacagcg 103741 ctcacggcca accgaatcgc ttacgacgag gtcgacatcg aacacaaccg tgcggccgcg 103801 gagttcgtcg gctcggtcaa tggcggcaac agaactgttc ccacggtgaa gttcgccgac 103861 gggtcgacgc tgactaaccc gagcgcggac gaggtcaaag cgaagctggt aaagatcgcg 103921 ggttaacgac gtggactttc attcgcacgc tgcccacgat tcgatgatca cgcgggcgat 103981 cgagatcgac ccgggcagta gcagtttcga ctccgacgca ctggaccaat cgccggcggc 104041 aagcgctgcg cgcacctcat cgcgggtgaa ccacgcggct tcggcgattt cgccgtcgct 104101 gaacgagaac tcctcatccg ggtcacccaa ggcatgaaag ccaaccatta acgaccgcgg 104161 gaacggccac tgctggctgc ccagatagcg cacatcgcga acggtcaggc cgatttcctc 104221 gcggatctcc cgggcgacgc agacttcgaa cgactctccg gcctcgacaa agccagccaa 104281 cagcgagaac atccgttccg gccacgccgc ctggcgagcc aacacggcac gatcagcgcc 104341 gtcgtgaacc aggcagatca ccgccgggtc gatacggggg aactcctcat gaccggtgat 104401 cgggttgacc cgtgaccagc cggccctggc cggtttcgtc ggcgcgccgt ctagggcgct 104461 gaatcgtgcg ttgtcatgcc agttcaacag cgccgatgcc gacgacacca gttggctgct 104521 ggtgtcgtcc atgattcggc cgagcccacg aaggtccacc gcctcggctg gtatgtcggg 104581 atcagcgatc ggctgcagcg ctgcccgcac cgcccagacg tggcggccgc cctcgacgcg 104641 acccaggaat accgcctctg gcggtggctt gtcggccagc tcgatggccg cgccaagcaa 104701 cacccggccg ttggcgacca gcacgcgatt gcgggaatcc acccgcagca atgccgcgcc 104761 tggccatccc gcggcggccg cctccatgtc ggtcctcagc cggtcggccc ggtcggcgcc 104821 gacgcgcgaa agcaacggaa cgcttctcag ctgaaaatcc acgccgctta cgttcgtcac 104881 tggcgcccca cctggtggcg acccgccgcg cccggctccg ccgcgcttgc gatcgccact 104941 agcgccccac ctggcgaata tagagcagcc ggtcgctggc ctcgatggcg tccacctcgg 105001 gcgccccaat gcgcagcagc tggccgtcac gtaccacgcc gagcacgatg tcgcgcaggt 105061 gccgcggaga cccgcccacc tcggcctgct ccacctcacg ttcggcaacg gccaggccgg 105121 cttccggggt cagcagatcc tcgatcatct ccacgacgct gggcgtcgtg gtagcgatgc 105181 cgagcagccg cccggcggtc tcggaggaga ccaccaccgt gtccgcaccc gactgccgca 105241 acaagtgctg gttttcggcc tcccggatgg acgccacgat cttggctttg ggcgcaatct 105301 cgcgcgccgt caacgtgacg agcacagcgg tgtcgtcgcg actggtggcg acgatgatcg 105361 aagacgcatg ctgagtgccg gccaacctca gcacgtcgga cttggtggca tcaccatgca 105421 cggtgaccag accggctgcc gcggcacgtt cgaggacacc cgaatcggtg tcgacgacca 105481 caatttcacc cggaactaac tcgtcactga ccatcgcggc caccgccgtt ttgcccttgg 105541 tgccgtagcc gatgacgacg gtatggttgc gcactctgct cctccaacgc tggatcttgt 105601 acgcctgacg ggatgtttcc gtgaggactt cgagagtcgt gccgaccaac aagatcaaga 105661 acgcaatccg cagcggtgtg atgacgaaga tgttgatcgc tcgcgcgaat tcggaaatgg 105721 gcgtgatgtc gccgtagccg gtcgtcgaca gcgtcaccgc agcgtagtag aggcaatcca 105781 gaaacgtcag ccgatcgccc tgggcgtcga ggtagccgtc gcggtcgacg tagacgatcc 105841 cggcggtgag cagcaacgcc accacagcga cgaccacccg gcgtgaaata acgcgagctg 105901 gactggcccg cctttgggga atgcgcagca cgccgacaag cgcgtaacca ggctgcgcgg 105961 tcagcttctc gttgagcccc cgcaaccgcc gccagctacc ggccaccgaa atccgtcacc 106021 ggttagcccc aatgcacgcc aaacgcacga cacaaatggt aaccacgtca ggtgtccgac 106081 cgccgaccgg cgcagtcggt cagtagcatg gccaactcgc cgggagcggg taactcgtcg 106141 gggacgaccg tgatgccgct gcgcacgtaa tagaaggcgg tacgcaccga ggatgtcgga 106201 catccccgca atgcggccca ggccagtcga tagacagcga gctggacagc ggcctgccgc 106261 atggctgccg gcccgtgcgg cggcttgccg gtcttccagt ccaccacggt ggcaccgccg 106321 tcggggtcga cgaacaccgc gtcgatgcgg ccgcgcacca cggtatcgcc gatcggcatt 106381 tcgaacggca cttcgaccgc cgccggggtg cgagccgccc acgatgatgc ggtgaacgcc 106441 ctctgcaacg cggccaactc ctcaggatcg cccacctcgc ggtccgctgc acctggcagg 106501 tcacccaggt caaacagcag ttcagcaccg taaaattgct gaacccaggc gtgaaatgca 106561 tcgcccaacc acgcgtgcgg gtccgggcgt tttggcagcc gacacatcag ccgctgccgc 106621 gcaccgaccg ggtcgccgac cagctccacc aaactgctga ccgacaaatg gttcggcaga 106681 ccacgggcag gtgctccccg cgccgcgtgc gcacgttcag ccaacagtgc atcgacgtca 106741 gtggaccagg gggcatcgcc cgggcgcggg ggatgatcga tgtcggtggt gcttccgggc 106801 aagtcggccg acatggccgc cgccaccagc gccgcgcccc gctccacatc gccgcgacgt 106861 gcggccaacg gatcagcggg ccaaaccgcc tcgatagcgt tgtcacacaa tgggtttcgc 106921 tcatcgccgg cgggcgccga cgcccactgc tcgacgactc cgcaaggatc accggcagcg 106981 gccgaacggt caatgatgtc cttgagttcg cacaggaatt ccgatggccc gcgcggcttt 107041 gtcccggtgg gcccccaatg gtggccggac accagcagag tgtcctcagc ccgggtaacg 107101 gccacgtaca acagtcgacg ctcctcgtca acgcgccgcc gatcgagcag gcgacgatgt 107161 tcggagatct tgtccgacaa ctgttttcgg tcagcgacag ctgacgtgtc cagtacgggg 107221 atgccgtgcg cgccggccga ggcgcgatcc ccacgcagca gcggcggtag ttcggcgggg 107281 tcggtaagcc agctgctgcg cgacaccgtc gacggaaaca ctccgcgcga caggtgtgcc 107341 accgccacca cctgccattc caagcccttg gcggcgtgca cggtcagcac ctggacccgg 107401 tcgcaggcga cggtcaactc ggcaggcggc aaaccgttct cgaccacctc ggcgacgtcc 107461 aaataagcca gcaggcccgc aaccgacgcc tcgctggacc tagcgctggc ccgttcggcg 107521 taccccgcga ccacgtcggc gaacgcatca aggtgctcgg gtccggccca gccacctgag 107581 accggggccg aggcccgcac ctcgcaatcg acgccaagca cgcggcgcac ctcggctact 107641 aggtcgggca gggaatgacc gaggcgaccg cgcagcgcgc tcagttcacc ggccaaggcg 107701 ccgatgcgcc catatcccgc caccgaatac ccctcggcgg aacctggatc gctgatggcg 107761 tcggccagac acggattgtc ggcgtccgcg ctggccgcca tcgcgatcga ttcgggcgac 107821 gccgttgacg gtgattcgcc actcagcgtc agcgcacgcc gccacagcgc ggcgaggtcc 107881 cgggcgccga gccgccaccg tgggccagtc agcacccgca tcgcggccgc cccggccgtt 107941 gggtcggcaa ccaggcgcag catggccacc acctcggcga cctcggggat ggacagtagg 108001 ccggccagcc cgacaacttc agccgggatt ccgcgggccc gcagggtatc agcgatagcg 108061 gcggcgtcgg cgttgcggcg taccagcacc gccgcggtgg gcggcttgac accgtccgct 108121 tctgcccgct ggtaacgcat ccgcaagtgg tcggcgatcc attcgcgttc ggcctgcacg 108181 tcgggaagca acgcgcagcg gacggctcca ggcggggcat ccggacgcgg ccgcaacgcg 108241 cgcaccgcaa ccgagcgccg ccgcgcctcc gccgatatgc cattggccac gcgcagcgct 108301 tgcggcgggt tgcgccagct ggtcagcagc tccagcaccg gcgcgggggt gccgtccgat 108361 aaggggaagt cggtggtgaa ccggggcagg ttcgtcgccg aagcgccgcg ccacccgtag 108421 atcgactgaa tcgggtcacc gacagccgtc agcgccaacc cgtcatcaac gccgccgcca 108481 aacagcgacg acaacacaac gcgctgcgcg tgccccgtgt cctggtattc gtccagtaac 108541 accacccggt agcgcctccg cagatcctgg ccaacttggg gagaggtcgc cgccaaccgt 108601 gcggccgagg ccatctgcat ggcgaaatcc atcactttgc cggcgtgcat ccgctcaccc 108661 aacgcgtcaa gcaacggcac caactccgcg cgctgggtct gggtggccag catccgcagc 108721 agccactggc tggggccgcg gtcacgctga tagcggcccg ccggcagagc gtggaccagc 108781 cgttccagct cgacgtgggt gtcgcgaagc gcgcgggtgt cgaccagatg ctcgccaagc 108841 tggccccata accgcaccac gatcgaggtg accgccgccg ggctcttgtc ggtgcacagc 108901 acgccgtcgt acccgctgac cacatcgaat gccagctgcc acagctcggt ctcgctcagc 108961 aacctggtat cgggttccag cggtagcagc aggccgtagt cgcgtagtag cgagccggca 109021 aaggcgtggt aggtgctgac taccggagcg caggccgccg ggtcgccgca gccgaggccg 109081 ataccggcca acctggccag acgggaccga acgcggcgca acagctggcc cgcggccttg 109141 cgggtgaacg tcaatcccag cacctggccg ggttccgcgt agccgttggc aaccagccac 109201 accacccggg cagccatcgt ttcggttttt ccggcgccgg ctcccgcgat gacgaccagc 109261 gggccgggag gtgcggcgat taccgcggcc tgctcagcgg tgggcgggaa aagtcctagc 109321 gcgcaggcta gttcagctgg actgtagcgt gccggtgccg cggtttgggt catggcgccg 109381 accctcggac gtgggccgga cagcccggcc gcagcgggca gtgggtgcac ccgtcgttgc 109441 gccgagcgat gaactgggga ccggctgtcg ccgcggccag ctgccggacg aggttgcgcc 109501 attcgtcgcg cgcggccggt gtgagtggat cctgtttgcg ttcggcgacg ccagcggccc 109561 cgcttttgcc gacatagacc agccgggcac cgccgggctc gtccccggcg cgcaccaagc 109621 cttcggccac cgccagctga tacatcgcca gctgggcgtg ctgctgggca tcgtccttgc 109681 tgaccggtgt cttgccggtt ttgatgtcga cgatcaccag gcggccggcc gggtcgcgtt 109741 ccagccgatc cgcccggcca cgcaaccgaa tttttctggc ttgaccgcta ccgtcctcga 109801 gggccccatc gatgtcgacc tccacgccaa cttcggtcag ctcggatcga ctctgagctc 109861 gccactgtac gaacgcctgg atcatcgcgc ggtgccgggc aagctcgttg gccgaatacc 109921 actgagcgcc gaacggcaga tggccccaca cccggtccag ttcagccagc agttgggatt 109981 cgctcctgcc cggctcggca aacagtgcgt gcaacaccga tccgacggca gacggcagct 110041 cgcgggtgtt tgttccgccg tgccgctcgg ccagccagcg cagtgggcag tcgttgagtg 110101 cctgcaaagt cgacggcgtc aacgtgacga gatcgtcgct atcgcacaac ggatcactcg 110161 tgctgaccgg ggccaggcca tgccactcgg acgggtcggc acctggcaca ccggctttgg 110221 ccaaccgggc caattgcgtt gccgcacaat cgcgatcggc gtcatctacc gcgcaggcag 110281 gcgcgcacac cacaacgcgt aaccggccta ccaccgccgc agccgacaac acgcgcggcg 110341 ccgagaccgg ctgcatcgcg acgggttcgc catcgccgtc ggcccactgg gcaatctcga 110401 aaaagaacgc cgatggcagc accgcctcgt gcccgccccc gcccgcgtcg ctatctacgg 110461 cggtcaccag caaccgccgc cgggcccgcc ccatcgcggt caccagcagc cggcgctcct 110521 cggccagcaa cggcgcgcgc atcgaggcat ccttcgtgac accgtcgagt tcgtccagca 110581 gccgctgggt gccaagcaca ccgccacgtg gaaccgtgtt gggccacaag ccgtcctgta 110641 ggccggcgat aactaccaga tcccattcgt gtcccagcgc ggcatgtgcg ctaaggacca 110701 tgacctgctc tgtcggggct gccggttcgg gtcgcacaac cggcagctgc agcgcggtga 110761 cgtgctcgac gagtccgcgc agggacgcac ccgaggtgcg ggacacgtaa tggtcggtga 110821 tgtcgaacaa ggcggtcacc gtttccaggt cccgggtggc ctggacagcc gccgcaccac 110881 catgctcgct ggccgccagc cagcggcgtt gcagacccga ccgttgccag gcagcccata 110941 gcgtgtggcg cggatcctgg ccacccagac ttcctgagcg gtggcagcgc gcggccgcgg 111001 tcagcacggc acgcacgcgc cgcagtgccc gcgaccctgg ccccgatggc ggcgcgtcgc 111061 cgccgagcac ttccaccagc aggtcgccga acttcctcga agtctggccg ggacgtgcgc 111121 gttgcagagt ccggcgcagc tggcgaagtg ataccgggtc cacaccacca atcggcccgg 111181 tgagcaggag cagcgcctgg tcgccgtcga gcccgtcagc cgtcgcctcg agcaccgtga 111241 gcagcgcccg taccgccggc tccgcggaca acggcccgcc aactgcaggt ggggccaccg 111301 gcaccccggc ggcggccaga gcgcgcggca accgcacagc gcgcggcacc gacctgacga 111361 tcaccgccat ctgcgaccaa ggcaccccat cgatcaggtg cgcgcgtcgc agcgcgtcgg 111421 caatcatcgc tgcctcagcg tgcgccgaac cggccaggcg caccgtcacc gatccgacct 111481 cggtcccggt gccctcgatt cgccgaccga cgcttcgacc cggtagccgt cgtgcgatgc 111541 cggtgacggc ccgcgccacg gcgggtgcac accgatgaga gaccgtcaac gtcaccgacg 111601 gaatgggggc accacctgct ggcggcggat cgtcggccag caggccggtg ggctcgccgc 111661 cgcggaaccc gaacaccgct tggttcggat caccggcgat cagggccagc tcggtgcccg 111721 ccgccagcat ccggaccagg cgtgccgcct gcggatcaag ttgttgggcg tcgtcgacca 111781 aaagggtccg gacccgggcg cgttcggcgg ccagtaactc aggatcgacc gcgaaggcct 111841 ccaaagctgc ccccaccagt tcggcggcac tcagcgccgg cgccgtggcc tgcggcgccg 111901 ccagccccac cgcaccccgc aacaacatca cctgctcgta ccgctgggcg aattgaccgg 111961 cggcgatcca ttccggacgg ccgcggcgac ggcccagttg ctgcaactcc agcgggtcca 112021 ggccgcgttc ggcgcaacgt gccaacaggt ttcgcagctc ggtggcgaag ccggcggtag 112081 tcagcgcggg ccgcagatgc gcaggccagg tggtggtggc ggccggtccg tcttcggcgt 112141 ccccggccag cagttcccga atgatggcgt cctgctcggc gctggtaagc agccgcggca 112201 aggcgtcacc ggcgcgctgt gcggccttgc gcaagaccgc ataggcgtag ctgtgcacgg 112261 tgcgtaccac cggttcgcgg atcgccgccc ggcaagggcc gttggtgcgc gaccgcagca 112321 gcgccgtcgt cagcgcactg cgggcccgca tgcccattcg gccggaaccg gtcagcagca 112381 gaaccgactc cgggtcggtg ccggcgccga tgtgagcgac cgcggcctca accaacagtg 112441 tgctcttacc ggtgcccggg ccgcccagca caagcaccgg accgcgcaaa cccggcgcga 112501 gggccgcacc cgcctcgaca ccccagatat gtgacatagc cgcatgacat cacgagggtc 112561 tgacaagctc ggatactgga gctggcaaga aaaccgaaaa cgcgatgtga ggggtggcta 112621 ccatggcggc ggtcgtaggc ggcggtccac aggacgaaat acccgaagcc gatgcggtgg 112681 agcaagggcg tgctgtcgat ttcgacgacg aagccgggtt ggacaccgcc tacctcagcg 112741 gcggcgccgg cgaccgagac gccagcgaag ccgacgtcgt cgaccaagcc ttcgtcgttc 112801 cggtcgccga cgacgaagaa atcgaccggt agcaggcgtc gccgggctgg catcatcgac 112861 gcgtgatcat cgaccttcac gtacagcgct acggcccgtc agggcccgcg cgggtgctga 112921 ccatccacgg agtgaccgag cacgggcgca tctggcaccg gttagcccat cactttgccc 112981 gaaatcccca tcgccgcacc cgatctgctg ggccacggta ggtcaccatg ggccgcgccg 113041 tggaccatcg acgccaacgt gtccgccctg gcagcactcc tcgacaatca gggcgacggt 113101 ccggtagtgg tggtcggaca ctccttcggc ggcgctgtcg ctatgcacct ggccgcggcc 113161 cgcccagacc aggtcgcggc gctggtgttg ctcgacccgg cggtcgctct ggacgggtcc 113221 cgggtacgcg aggtggtcga cgccatgctg gcctctcccg actacctgga ccccgccgag 113281 gcccgggccg agaaggcgac cggtgcctgg gcggacgtgg accccccagt gctcgacgcc 113341 gaactcgacg agcacctcgt cgcattgccc aacggtcggt acggttggcg tatcagcctg 113401 ccggcgatgg tgtgctactg gagcgaactg gcccgcgaca tcgtgctgcc gccggtggga 113461 acggcaacca cgctggttcg ggcggtccgt gcgtcaccgg cgtacgtcag cgaccagctg 113521 ctcgcggccc tggacaaacg gctaggagcc gattttgagc tactagactt cgactgcggg 113581 cacatggtgc cccaagccaa gcccactgag gtcgcggcgg tgatccgcag tcgactggga 113641 ccgcgctagc catggcgccg gtgaccgacg aacaggtgga gctggtgcgc tcactggtcg 113701 cggccatccc actcggccgg gtgtccacct acggcgacat cgcagctctc acagggcttt 113761 ccagtccgcg tattgtcggc tggattatgc ggaccgattc ctcggatctg ccctggcacc 113821 gggtgatcag agcctccggg cgcccagcac agcacctggc cacccggcag ttggagttgt 113881 tgcgcgcaga gggcgttctc agtgttgacg gccgggtggc gctgagcgag atccgctatg 113941 agtttccgcc gggctgagta ggtttagagc actagccgca ctagggccgc ggtgtgggcc 114001 aggccgggaa acgcttcggc ggtggatcgt gggtgcagcg cgtacactgc taggcggaac 114061 atcaacgcgc gcaacaacat ctggggccac tccggcagcg cgttccaccg ctcgatgagc 114121 ccgtcgtcgg ccgcacccca ggacagcgcg tcgacgacgg ccaccccggc cgcccaggat 114181 gcgggccgcc agtagggcgt gatgtcggtg atccctggag gggcggtgcc cgcgaaaagc 114241 actgtaccgt aaagatctcc gtgcaccagc tggttcgggc tcttggtcgg cttacgcaac 114301 ccggcaagct gattgatcag atcgatcgat cgctgggggt ccgctgccgg gggggcggtc 114361 ggcacgcccg gtgggaccga ctgtaatggc cgctcctccc acccagctcg gtctgcggcg 114421 acgaacacat cgatctcggc ccagggcgcc gcgggtccct gggtcaagaa tcgggggcgt 114481 tccagttttc cggtggcctc atgcagccgc accgccgccg agacgacctc atcatgccta 114541 ggctccggcg cgccggcgac gaacgtgtct gcccgccaac cagacaccac gtaccggccg 114601 tcggtcgatc ggacgggccg agccaggcgt acgccgtcga cgaacaacgt ctcgcgcacc 114661 cgggccgacc aggccgcgcg ggcgttgtcg gccaccatcg acaacaccac ctcgccgcat 114721 cgccagccac cttcccaacc ggcacccaac aggatgggtt gcgcacctgc caaaccgaac 114781 gccaccaaca cgtgctcggg cggcggctcg acattcacac cggtcagcct agtagagccc 114841 atcggggtgt attgggcctg tatcggtcct agtacatcac catgtcgggc tgcatctgct 114901 tggcccacgc gacgatccca ccctgcaggt gtaccgcgtc ggagaaaccg gctttcttga 114961 ccgcagccaa tgcctcggcc gagcgcacgc ccgtcttgca gtacagcacg gcggtgcggt 115021 cctgggggag cttggccaga ccctcacccg agttgatcaa cgatttcgga atcagttggg 115081 ctccgtcgat atgcacgatg tcccactcca cgggatcgcg aacgtcgatc agtgccagct 115141 tacggccgga gtccagccag tcgcgcagct cgcgcggcgt gatggtggaa cctttggccg 115201 cctgggcggc atcgtcagca accacgccgc agaactgttc gtagtcgacc agctcggtga 115261 tcttcggtgt cgatgggtcc ttgcggatgg tgatcgtgcg atagctcatc tccagcgcgt 115321 cgtacaccag caaccggcca agcagtgttt cacctatccc ggtgatcagc ttgatcgcct 115381 cagtgcccat caccgatgcg accgaggcac agataatgcc cagcaccccg ccttcagcac 115441 aggacggcac catgcccggc ggcggcggct cgggatacag gtcgcggtag ttgacaccca 115501 acccgtcggg ggcgtcctcc caaaacaccg atgcctggcc ctcgaagcgg taaatcgacc 115561 cccacacgta cggcttgcca gccagcaccg cggcgtcgtt gaccagatac cgggtggcga 115621 agttgtcggt gccatccaag atcaggtcgt actgcttgaa caggtcgacg gcgttgctcg 115681 gcgcaagccg cagctcgtgt agtcgcaccc ggatcagcgg gttgatcgcg acaatcgaat 115741 cgcgcgccga ctgagccttg gagcgcccga cgtcagctac cccatggatg acctggcgct 115801 gcaggttcga ctcgtcaacc acatcgaagt cgacgatgcc gatggtgccg acgccggcgg 115861 cggccagata caataacgtg ggcgctccga gcccgccggc gccgatcacc agtactcgcg 115921 cgttcttgag cctcttctgc ccgtcaacac ccaggtcagg aatgatgaga tggcggctgt 115981 agcgagctac ctcttcacgg ctgagcgcgg atgctggctc aactagtggc ggcaaggatg 116041 tcgacaccga atatctcctc ggttatatcc gaaacgtctg ctgcgcgtcg tcctgcaaat 116101 acctcaacgc ccagcttgcc acctttgctt ccccgggtta gggaatcggg tagggccagg 116161 gattgaatcg gcaggtcttt ccatccgcct taacgaagtc ggggtcaaac ttggccgcgt 116221 cgtcattgga ggtggaaaac gtctgctgca tcattaccgg agccagaccg ccttgttggt 116281 cgcacggctc gtggcgcagg taaccgatgg catgaccgac ctcgtggttg atcacatatt 116341 gccgatagga acctacgtca ccttcgaatg gaacggctcc gcgtacccag cgcgcctcgt 116401 tgatgaacac ccgcgattgg cgatccatgc cgccgaacga cgggttgtag caggacgtct 116461 cgagccggaa ttcgtagcca caccccccgc gcactgtcgt cggcgacacc agcgaaatcc 116521 ggaagtcggg ttttccgctg tcgatccgca cgaacgcgaa ttgcggattg tgggtccagc 116581 ccttgggatt ggtcaacgtc tggtcgacca tctgggcgaa tgcgttgtca ccgccgtaca 116641 ttgtgggatc aagaccgttc tcgatctcga cggtatacct gaacactttg acggtgcctt 116701 gaccgacctg gggagtagtg cccggaacga cacgccaggt cttgtcacca gcctcggtga 116761 acgggccgcc atccggcagc gtcccggccg gcagattggc atcgaacact gcaagaccgc 116821 gaggcggtgc gtcgaggatc gcggtcccca ccacaccaat ggccggcgag tcccggacgg 116881 tctgggccgc cgcgggcctt ggcgtgctcg tcccggtcac cgtctggtac accaccaccg 116941 tggtcagcac catcagaacc ggcagggcgt aggcgcgcca gccgtacgtg gacacgaacc 117001 gccccaacca ggtttgtttg cgccattgac gcttccggtc gcggcgggcc cggacccgtc 117061 tgtcagtcgc ggcgagcggg tcgcgcaggg cccgcagcgg ctcacgccac tcgtcacgca 117121 gcacgggtac tcgactcgtg cttccggcgg gccacggaga cgtcatttcc tcaggatgac 117181 acagctggcc cgggtcgcga ccctggcgcg cccgaatgca acacccaaca aactatcccg 117241 ccgctaccga tgccgcaggt agtaatgtca ttccgacaga cgcgcggcgg tgggggttgg 117301 cacagtggcc ctcgaattag tgtgatcaga ttgaggactg atgagcgatc tcgccaagac 117361 agcgcagcga cgtgccctca gatcgtccgg cagcgctcgg ccagacgaag acgttccggc 117421 cccgaaccgg cgcggcaacc gactgcctcg cgacgagcgc cgcggccaat tgcttgtcgt 117481 tgccagtgac gtcttcgtcg atcggggtta ccacgcggcc ggtatggacg agatcgcgga 117541 tcgggcggga gtcagtaaac ccgttctgta tcaacatttt tcgagcaagt tagaacttta 117601 cctggctgtg cttcatcggc acgtggaaaa cctggtgtcc ggcgtgcatc aggcgctgag 117661 cacgactacc gacaaccggc agcggttgca cgtggccgtc caggcgttct tcgacttcat 117721 cgagcacgac agccagggtt accggctgat cttcgagaac gacttcgtca ccgagcccga 117781 ggtcgccgca caggtgcggg tggccaccga atcgtgcatc gacgcagtgt tcgcgctgat 117841 cagcgccgat tccggactgg acccgcaccg cgcccggatg atcgcggtgg gcttggtcgg 117901 aatgagcgtc gactgcgcca gatactggct ggacgccgac aagccgattt ccaagtccga 117961 cgccgtcgag ggcaccgtgc agttcgcctg gggcgggttg tcccacgtcc cgcttacccg 118021 ctcgtagcaa cctttccggc ggacccagct gcggcgtcca ccccgacgcc gaagcccacc 118081 cggcgggcgt ctgcgacacc gatctcgaca taggcgatcc tggcggtgtg aattaggaag 118141 cgacggcccc gctcgtcggt cagggtcagc aaaccagagt cgtcgcgcag cgcgttgctg 118201 acgagttctt ctacctcact gggcgtctgc gcactggaga acaccagctc gcgcggactg 118261 tccgtgatac cgatcttgac ctccacggtg gccccttcca ttggcattcc gtcacaggcg 118321 tgtcaccagc aggctagtag acgcccctgg cccccataac ggttaggtct aggccagccc 118381 gacacgccgc cagacacccc atccgccggc aggggctcga taacatcagc accatcggta 118441 acacagttaa cgacctctac gagtgcgttc ggaacgtccg ggaagtccag gactacccgg 118501 acgacgagag ctcgagcggc ttcggggctg gccggacctg ttcggaaggc gagtttgcct 118561 gggcggctga ccgccgatgg cgcccggtag ctgcgatcct cggcagtgtg gtggcgcttg 118621 gcgcggtcgc gaccgcagtc attatcaaca gcggagatag cacgtcgacc aaggccattg 118681 tcggggcacc agccccgcgc acggtgatat ccacctcgcc acgaccaacg gccccgacca 118741 gcacgtcacc ccacccttcg cccagcacct tgcggccgca gctcccgccg gagacggtca 118801 ccacggtggc accgccgggc accgggccta ctaccgtgcc gacgcgaacc cccaccgccg 118861 cgccacctca gactgctgtg ccaccgccgg cgccgctgaa tccgcgcacc gtcgtctacc 118921 gcgtgaccgg caccaagcag ctgttcgacc tggtgaacgt cgtctacacc gatgcgcggg 118981 gcttcccggt gaccgacttc aacgtgtcgc tgccgtggac gaagatggtc gttctgaacc 119041 ccggcgtgca aaccgaatcg gtcgtcgcga ccagccttta cagtcgtctc aactgctcga 119101 tcgtcaatac cggcgctcag acggtggtgg cgtcaaccaa caatgcgatc atcgcgacat 119161 gcactcgcta gatctgggat ctagctgaga cccagttccc gcatgcgttg gtcgtgggtc 119221 tgctgcaacc ggtcgaagaa ggcaccaagc tggctcagtc caccactacc ggacaccacc 119281 aggtcgacca gctcgtcgtg gtcggccaac accagctggg cctgcgttat cgcctcgccg 119341 agcagacgac gcgaccacag cgccagtcgg ctgcgctgtt tgccgctggc cgtcaccgct 119401 gcgcgcactt cggcgacgac gaactgagag tgcccggtct ccgacaacgc cgcccgcacc 119461 acgtcagcaa cctcgtcagg cagcccgtcg gcgatctcca gatacaaatc ggcggccaac 119521 gcatcggcaa cataggtctt caccagggct tccagccatg tgctcggcgt cgtcagccgg 119581 tggtagtttt ctaacgctga ggtgtacttc gacatcgccg acaccacgtc gacgccgcga 119641 cgttccaacg cattgcgcag cagctcgtag tgccccatct cggcggcggc catggatgcc 119701 atcgagatcc ttccccgcag atccggggcc atgcgcgcct catcggtcaa tcggtagaag 119761 gcggcaactt cgccgtaggc cagcaacgcg aacaattcgt tgacgccggg atgatccgcc 119821 ggcagccgtg gcctgggtga atcggccacc tgatcggcgg atgagggcga tggcatggca 119881 acactctagt aggcaggctc agcggcaaat gggaacctgc tggccgacca gctatcatgc 119941 tcgttaggtg gcggcattgg ttcgactgcc gctaccggcg aaatgtgcgt gcatggagtc 120001 tgccccgcct ggactgtgct aggggccggc gactcggcga cgtaatcgga gtcggaactc 120061 atgcgcgcgt gaaccgcgac agagaaacac cgacacacga ccgacaccgt caccgaaagg 120121 ccgcttaccc tcgtatgacc gcagtgaaac acacaactga atcaacattt gccaaacttg 120181 gagtccgcga cgaaatagtc cgcgcattag gggaagaggg catcaaacgg ccctttgcta 120241 tccaggaact caccctgcca ctcgcgctcg acggcgagga cgtgatcggc caggcccgca 120301 ccggcatggg caaaacgttc gcttttggcg tgccgctgct gcagcgcatc acctccggcg 120361 acggcacgag accgctcact ggcgctccgc gggccctggt cgtagtcccc acccgcgagc 120421 tgtgtctaca ggtcaccgat gacctggcca cggcgggcaa gtacctgacc gccggccccg 120481 acacagacga cgctgccgcg gtacggcgcc ggctgtcggt ggtgtccatc tacgggggac 120541 ggccctacga gccgcagatc gaggcgctac gcgccggcgc cgacgtcgtg gtcggcaccc 120601 cgggtcggct gctcgacctg tgccagcagg gccacctgca gctgggcggg ctatccgtgt 120661 tggtgctcga cgaggccgac gagatgctcg acctgggctt cctgcccgat atcgagcgaa 120721 tcctgcggca aattcccgcc gaccgacagt cgatgttgtt ttcggcgacc atgccggacc 120781 cgatcatcac gctggcccga acgttcatgg tccggcccac gcatatccgg gctgaggcac 120841 cacattcctc agcggttcac gacgcgaccg agcagttcgt ctaccgcgcc catgcgttgg 120901 acaaagtgga gttagtcagc cgggtgctgc aggctcgtga ccgcggcgcg acgatgatct 120961 tcacccgcac caagcggacc gcccagaagg tcgccgacga gttgaccgag cgcggtttcg 121021 cagtcggcgc cgtgcacggt gatctcggac agctggcacg cgagaaggcg ctcaaggcgt 121081 ttcgcactgg cggcatcgac gtattggtgg ccaccgacgt ggccgcccgc ggcatcgaca 121141 tcgacgacgt tacccacgtg atcaactatc agtgccccga agacgagaag atgtacgtcc 121201 accgcatcgg tcgcaccggc cgtgccggcc gaaccggggt cgcggtcacc ctggtggact 121261 gggacgagct gccccgttgg agcatgatcg accaagcact gggcctgggc tcccccgatc 121321 cggccgagac atactccaac tcgccgcatc tgtatgccga gctggccatc ccggccacgg 121381 ccggcggtac cgtcggcccg gcgcgcaaat cgcagggcag gcgacgtgac accgactgcg 121441 acggccagaa aacggcacag cacgcccgca atacccccag gcgtcggcgc acccgcggcg 121501 gcaaacccgt caccggacac cccggcacca acccaatcag cagcccaatc gtgggcggcg 121561 acgccacctc ggagccgggc tccggcaccg catcagattc cgggtccgat gttgtgtccg 121621 gctcccggtc cggcaacggc gaagctgcgc gacgccgtcg tcgccgccgc cgacgcccga 121681 cgcacgccca ggacggcttc gccgcgcggg ctaactgacc cgcccaccgc atggttaaac 121741 cggagcgccg caccaagacc gatatcgcgg ccgccgcgac gatcgcggtc gtggtggccg 121801 tggccgcgtc gttgatctgg tggaccagcg acgcccgcgc caccatcagc cggccggcgg 121861 cggttgcggt gcccaccccg gccccggctc gcgaggtccc gacctcgctg aagcagctgt 121921 ggaccgccgc cagcccagcc acccgcgttc ccgtggtggt gggcggaaca gtggctactg 121981 gcgacggacg ccaggtggac gggcgcgacc cagccaccgg tgagtcgctc tggagttacg 122041 cccgagacac cgatctgtgt ggggtgacct gggtctacca ctacgccgtc gcggtctatc 122101 ggtacgaccg gggttgcggt caggtcagca ccatcgatgg atccaccggt cgccggggag 122161 ccgcccgcag cggctacgcg gatccgcggg tgcgtctttt ttccgacggc accacggtgt 122221 tgtcggccgg ggacacgcgc ctggaactgt ggcgttcaga catggtccgg atgctggcct 122281 acggcgagat cgatgcccgg gtgaaaccgt cgaaccgcgg cctgcagtcc gggtgcacgc 122341 tggagtcggc ggcggccagc tcggcggccg tatcggtgct tgaagcgtgt acgaaccagg 122401 ctgacctgcg gcttgtgctg ttacgcccgg gcaaggagga cgacgagccc atccagcgca 122461 ttgtcccgga accgggggtc cggccgggtt cgggcgcccg ggtattggtg gtatcgcaga 122521 acaacaccgc cgtgtacctg cctgcaagat caggcgcgca accgagagtc gacgtgatcg 122581 acgagaccgg cgccacagtt tcgagcacgc tgctggccaa gccaccgtca acttcggccg 122641 tggcgtcgcg gaccggcaac ctggtgacct ggtggacggg cgacgcgttg ttggtcttcg 122701 acgcgggcaa cctgacccag cgctacacca ttgccgctgg cgagacgact gcgccggtgg 122761 ggccaggggt gatgatggca ggtcaactcc tggtgccggt caccggcggg atcggtgtct 122821 atgacccggt cagcggtgcc aacaaccgtt atatcccggt gacccggccg ccaagcacgt 122881 cagcagtgat cccggcagtt tctggatcca gggtcattga gcaacgtggc gacacactag 122941 tcgctctggg ttgatcgcct atgttggcgc gagcagacgc aaaatcgccc gaaaccgatg 123001 gctttcgggc gattttgcgt ctgtcgcgct acaggtccac cgtgaaggtg ggcagcggcc 123061 tacctgtctt ccagtgtttg agcagcgcct gcgccagctc gcggtaggcc accgcgcctt 123121 tgttcttgcg cccagccatc accgacgagc ccgaggcgct ggcctcagcg aagcgcacag 123181 tacgggggat gggcggagcc agcacctgta ggtcgtagcg gtcggcgaca tcgagcaaca 123241 cgtcacgggt gtgggtggtt cgagagtcgt acagcgtcgg cagtgcaccc aacaaccgca 123301 gattcggatt ggtgatctgc tggacatcgg cgaccgtccg cagaaactgg ccgacacccc 123361 ggtgcgccag catctcgcac tgcagcggca cgatggcctt gtcggcggcc gtcagcccgt 123421 tgagggtgag cacacccagc gacggcggac agtcgatgat gaccacgtcg aaccggtcgg 123481 agaatttggc caacgcgcgt ttgagcgcgt actcacggcc tgcccgcatc agcagcattg 123541 cctcggcgcc cgccaagtca atgttggccg gcagcaacgt cattccctcc atggtggtga 123601 ccagcacggc gttgggctcg acttcaccga gcaacacctc gtgcacagac accggtagtt 123661 tgtcgggatc ttgaccaagg gagaaggtca gacaaccttg cggatccaga tcgacgagca 123721 gcacgcgccg tcccttttcc accatcgccg caccgagcga ggcgaccgta gtcgtcttgg 123781 ccaccccgcc cttctggttg gccaccgcta gcacccgggt atcagtcata ggcgccgctc 123841 tcccccgcaa gcggcaggga cccccacctc atcgtgctct cccttcgtcg tcgcccgcgc 123901 agtcacagtg tcatcctggc atgctgctcg cacagtggtt cgggcgacag gcctaggatg 123961 tcgtcgggca caatctgtcg gtatgggcgt gcgcaaccac cgattgctac tgctccgcca 124021 cggcgagacc gcttggtcga cgctgggccg gcacaccggc ggtaccgagg tcgagctgac 124081 cgataccggg cgaacgcagg cagagctggc tggtcagctg ctgggtgaac tcgaacttga 124141 cgacccgatt gtcatctgta gcccgcgtcg acggacgttg gatactgcca agttggccgg 124201 cctgacggtg aatgaggtaa ctgggctgct cgccgaatgg gattacggtt cctatgaggg 124261 ccttacgacg ccgcagatcc gggaatccga acccgattgg ctggtgtgga cgcacggctg 124321 cccagctgga gaaagcgtcg cacaggtaaa cgatcgcgct gacagcgccg tcgcgctggc 124381 cctggagcac atgtcctcac gcgacgtgtt gtttgtcagc catggccact tctcccgcgc 124441 ggtgatcacg cgctgggtcc agctaccgct cgccgaaggc agccgtttcg cgatgcccac 124501 cgcctcgatc gggatctgcg ggttcgagca cggcgtgcgt cagctcgccg tgctcgggtt 124561 gaccggtcat ccgcagccga tcgcagccgg gtgagcgcac acgtggcaac cttgcaccca 124621 gaaccaccgt tcgcactgtg cggaccaaga ggcaccctga ttgcccgcgg ggtgcggaca 124681 cgatactgcg acgtgcgggc cgcgcaagcg gcacttcgct caggtacagc accaatactg 124741 ttgggcgcgt tgcctttcga cgtgagcaga cccgccgcat tgatggtgcc ggatggcgtg 124801 ctgcgggccc ggaagctgcc tgactggccg accggcccgc tgcccaaggt acgcgtcgcc 124861 gccgcccttc cgccacctgc cgactacctg acccggatcg gccgcgcacg ggatctgctg 124921 gccgccttcg acggcccgtt gcacaaagtg gtgctcgcgc gcgccgtgca actgaccgcc 124981 gatgctccgc tggacgcgcg ggtactgttg cgcaggttgg tcgtcgccga cccgaccgct 125041 tacggctatc tcgtcgacct cacctctgcg ggcaacgacg acaccggggc agccctggtc 125101 ggcgccagcc cagagcttct ggtcgcacga tccggcaatc gcgtcatgtg caagccattt 125161 gccggctcag ccccacgcgc cgccgacccc aaactcgacg ccgccaacgc ggccgcacta 125221 gccagttcgg ccaagaaccg acacgaacac caattggtcg tcgacacgat gcgggtagcc 125281 ctagagccac tatgcgagga cctgacaatc ccagcccagc cccagttgaa ccgcaccgca 125341 gccgtttggc atctgtgcac cgcgatcacc ggccggctgc gcaacatctc gacgacggca 125401 atcgatctgg ctttggcgct acatcccacc ccggcggttg gtggggtccc gacaaaagct 125461 gccaccgagc tcatcgccga actcgagggc gaccgtggct tctacgccgg cgcggttggt 125521 tggtgcgacg gccggggcga cggccattgg gtggtgtcta tccggtgcgc gcaactttcg 125581 gctgatcgac gcgcagccct tgcgcacgct ggcggtggca tcgtcgccga atcagacccc 125641 gatgacgaac ttgaagaaac cacaacgaag ttcgccacga tattgaccgc actgggagtt 125701 gagcagtgac cgataccatc cgccgcgcta caccggcgga taccgccgac atcgtggcca 125761 tgattcacgc gctgggcgga attcgagtat gccgccgatc aatgcactgt caccgaaaca 125821 caaatacata cagcactttt cggagatttc ccgacgatgc gaggccacgt cgctgaggtt 125881 aatggcggag ttgccgcgat ggcgctgtgg tttctgaact tttccacctg ggacggcgtc 125941 gcgggcatct atgtggagga cttgttcgtc tggccgaggt ttcgccgccg cggcttggcc 126001 cgtggcctgc tgtcgacgct ggccagagaa tgcgtcgaca accgctacac gcggttggcc 126061 tggtcggtgc tgaactggaa ttccgatgca atcgcactgt atgaccgcat cggcgggcaa 126121 ccgcagcacg agtggactat ctatcgactg tcaggaccgc ggttggctgc gctggccgca 126181 ccacgctgat cacgcccggc ggcccagcgg atcgaaggcg gactgaacag caataccagc 126241 acgccaagcg cgatgattcc caccgggatc ccgatcgccg gctgatgcga acccacaatc 126301 agataccacg ccaccggcag cagcagcagc tgggcgaaca ccgccagccc gcgaccccaa 126361 agcttgccaa ccgccagcct gcatccggcg gcgagcactg ctccgccgac cagtacgaac 126421 caacctgcgg tgcccaggcc attgacgatg tgctggtcgg cgcccgcgag tccgcgcacc 126481 agcaacgccg cggccaccac cagggcggcc ccaccctgca cggcgacgat cagtccggcg 126541 ccgcgcacgg cggccggggc tcgaacaggc acagcatcag cgtagtcacc cggccgtgac 126601 cggcccgcat cgtcacacca cccaggccca ttgccgtcct cctcaacggg ccgacccggc 126661 ccgcatcgtc acacggccta ggcccattgc cgtcctcctc aacgggccga cccggcccgc 126721 atcgtcacac ggcctaagcc cattgccgtc ctcctcaacg ggccgacccg gcccgcatcg 126781 tcacacggcc taagctcgtg cgtcatgcgt gcagtgctga tcgtcaaccc cactgcgacc 126841 gccaccacac cagccggccg cgacctgctg gcgcacgccc tcgaaagccg ccttcagctc 126901 acggttgagc acaccaacca ccgcggtcac gggaccgaac tcggacaggc ggcggtagcc 126961 gacggggtgg acctggtcgt ggtgcatggc ggcgatggca cggtaagcgc cgtagtcaac 127021 ggcatgctgg ggcgccccgg cacgacgccg gtccgaccgg tgccagccgt tgcggttgtg 127081 cccggcggct cggccaacgt actagctcgc gcgctaggga tttccgcgga cccgatcgct 127141 gccaccaacc aactcatcca gctgctcgac gactacggcc gccaccagca gtggcgccgc 127201 atcgggctga tcgactgcgg tgagcggtgg gcggtgttca acgccggcat gggcgtcgac 127261 gccgaggtcg tggccgcggt agaggccgaa cgcgacaaag gcggcaaggt tacggcgtgg 127321 cgctatattc gcgctgcggt gcgcgcggtg ctcgcctgca ctcgtcgcga accggctctt 127381 acgctgcaac ttcccaaccg cgatccaatt accggagtgc actttgtgtt cgtgtccaac 127441 tccagtccgt ggacttacgc aaacaaccgg ccggtatgga ccaatcccga ctgcaggttc 127501 gagtcggggc tgggagtgtt cgccaccacc agcatgaagg tggtcccgac cctgagggtg 127561 gttcggcaga tgttcgcaaa acagcccaag ttcgagttca accacgtcat caacaacgac 127621 gacgtcgcgt gtctacgcgt cacctccatg gggcccccga tcgccagcca attcgacggg 127681 gactacctcg gcgtgcgcga gacgatgacg ttccgagctg ttcccgacgc cctcgccgta 127741 gttgccccgc ccgcaagaaa gcggatctga gctgcagaaa caaagatgtg atgggtgtgc 127801 gacacaaacg ttgggcgaaa ctggcagcgt agtgtagtac aactgggtaa gggctgtgga 127861 acgagatcgc cagagtgaga tagcccacgc gcttacgtaa cactattgac atctgttgag 127921 cctgtgaaac gatcaaaagg ttgcatgtag agaaatgtag gggtacagaa gcctttcttg 127981 tgcacccgtt accagccaag aagaaacgcc tgtgcgtacc gctgcgcaca tagtgaggag 128041 taacgactaa tggattggcg ccacaaggcg gtctgtcgtg acgaggatcc ggaactgttc 128101 ttcccggtag gaaacagtgg tccggcactt gcgcagatcg ctgacgcgaa actggtctgt 128161 aatcggtgcc cggtcaccac agagtgcctc agctgggcac tgaataccgg ccaggactcg 128221 ggcgtctggg gaggcatgag cgaagacgag cggcgcgcgc tgaagcgtcg caacgcccgc 128281 acgaaagccc gtaccggggt ctgacgactc agttctgcac agtgcggccc cgacatacgt 128341 cggggccgca ctgttgcgta gcgcgctaca gcatcaaccg tccccggcgt ccgaccggta 128401 cccgtagcac cacatcggtg ccacgttcgc gggcgtcccg catacctaac gagccgtcca 128461 attccgcaga gaccaaggtc cgcacgatct gcaggcccag gctgtccgac ttctccaggc 128521 tgaaaccttg cggcagacca agcccgtcgt cgtgcacgac gacatcgagc caacgcgcag 128581 agcgttccgc tcgaatcgtc acggaccctt ccgccgccgc cgggtcgaac gcatgctcga 128641 tcgcgttctg caccagctcg gtgatcacca tgatcagcgc cgtggcgcgg tcggagtcga 128701 gcacaccgag gtcgccaacc cgatttatcc ggatcggcct gtccaccgat gccacatcgt 128761 tcatgatcgg cagaatccgg tcgatgacct cgtcaaggtt cacctgctcg tccaccgaca 128821 tcgacaacgc atcgtggacc aaggcaatcg acgacactcg gcgcaccgac tcgatcagcg 128881 cttcccgccc ctcggcgttg gacgtccggc gagcctgcag ccgcaacagc gcggccaccg 128941 tctgcaggtt gttcttaacc cgatgatgga tttcccggat cgtggcgtcc ttggatatca 129001 gggctcggtc gcgccgcttc acctcggtca cgtcgcggat caatatcgcg gcgccgacat 129061 tgcgaccagc taccaccagc ggcagagtcc gcagcagcac cgtggcgccg ccggcgtcga 129121 cctccatccg catacccttt ccatccccgg ccagcaagtc ctgcacatgc tcgtctacct 129181 cgtgcgcctc gaacgggtcc gagatcagcg ggcgcgtcgc gtcaatgaga ttgacgccct 129241 ccaactcggt ggtcaaaccc attcggtggt aagccgatag ggcattgggg ctggcgtaag 129301 agaccacacc gtcgacatcg agacggatga agccgtcacc cgcgcgcggg ctagatcgcg 129361 acatcgccac gtcccctgcg tcgggaaagg tgccctccgc cagcatccgg agaagatctg 129421 tggcgcacaa ccgataggcg gtctccaggt ggccggatct acgtcgcgcc gccagttcgg 129481 gttgatgccg tgtcagcacc gccaccacct gatcgccaaa gcgcaccggg gagacttcga 129541 cactgtggcc gtcgtgttga catgaattct gttggccgac agcgccttcc cgtcccggga 129601 caccaccgga gaaggtcgcg gcgaccagcg gcatgctatt ggcggcgacg acggtgccta 129661 ccgcgtcggt atgcaccacc gtcggcccgg tgttcggccg gcattgcgca acgcacacca 129721 ggacaccgtc gtcgcggcga acccacatca ggtaatcggc aaacgacaag tcggcaagga 129781 gctgccactc cccgaccacc gcatgcaggt ggtccaccgc gctgcccggc agcaccgtgt 129841 gttcggcgag cagatcaccg agtgtggaca tgagtgacta tcaacgacta gctgatcacc 129901 gcgataaggt cgccggcctg aatgacatcg cccaccgata ccgccacctt gctgaccgtt 129961 ccggcagctt cggccaggac ggggatctcc atcttcatcg actccagcag caccacgacg 130021 tcgcccttgt cgatctgatc gccttcgttg acaacgactt cgagaacgct ggccacgatc 130081 tcggcgcgaa catcctcggc catcatcacc ccactctttt cggccatgcc gtatgctgac 130141 tgctggtcat cggacttcca tcaaactcag gtatatcgaa ccataagaac cctggggagc 130201 gcggcacgcg ggctattggg gtcgcgcgcg acgccgcatg agaaactggg caatgaccgg 130261 gcggccgctg cctgcccgca cctgagcaat gacggaggtt ccgatggcca agcgtggccg 130321 taagaagcgt gaccgcaagt acagcaaggc caaccacggc aagcggccca attcctaacg 130381 cactgcgcta gggccctcca cggatgatgg tggtccggcg gatctctagc cgaagacgct 130441 cccgcaagcc ctcgggggcc ctgtcgcctc ggcacttggt cccgatcaac gccttgatcc 130501 gttcctcgag cccgtaatgc ctcaggcacc ccgggcaggc ctcgaggtgt cgccgcagcc 130561 tctcgcgggt ttccggggtg cattcaccgt caagcagggt ccacacctcg gcgatcactt 130621 ccgcgcaacc catgccgccg tgggaatcgt cgtggtccgc gtgcgcatcg gtcggaccgc 130681 aattttcgct cactggtgca ccatccttgt gtcggtgatc tcggatggat tgccgatgta 130741 gaggcgccgc tgggttagcg ccccgcgcgc ttgacagccg tgatgtccat catgagtttt 130801 gcggagtccg gcggttgccc cggacgcgcc gaccgtcgac agggccaagc gccgacgagc 130861 gccgaacgac tcgccccgca cgccgacgcc cagcccgaat tgctggcctg cttggccggc 130921 gtcgcccgct ccaccggcta gtccgacaaa gtcacccacg tcgggttcgg ttgggcggca 130981 gacaaacaac tccgcaacgg tgtctgcgac ttcgccggcg acagccgccg agccaacctc 131041 taggccgccg acctgcacaa ccgcacccga gcccgcggcc acgaccaccg gcacgcggta 131101 cgcatcctcg cccgcgcctg gctttacgtc atctgacacc gctggcaaga cggcatcgct 131161 tacgacccca cccaacaccg agccctgcag gctctccttg accaagttcg ccaaacggcg 131221 gcttgacacc gggctgctca tgacgacacc ccctcgtgcg cctgctcgcc cctggcaaac 131281 ccccgatccc tggccacatc ggctaaaaga ccgcgcaact gacgtcggcc gcgatgaagc 131341 ctcgacatca cggtgccgat cggagtatcc atgatctcgg cgatctcctt gtaggggaaa 131401 ccttcgacat cggcgtagta gaccgccatc cggaactctt ccggcaatgc ctgcagcgcc 131461 tctttgatct cggtgtccgg caacgcttct aacgcttcga cttcagccga gcgcagcccg 131521 gtcgaggaat gctcggcgtt ggacgccagt tgccaatcgg tgatctgctc ggtcggatac 131581 tccgccggtt gccgctgttt cttgcgatag ctgttgatgt aggtgttggt cagtatccgg 131641 tagagccagg ccttgagatt ggtaccgtgc cggaacgaac gaaatcccgc ataggccttc 131701 accatcgtct cctggagcaa gtcctcggcg tcggccggat tgcgcgtcat ccgcagcgca 131761 ccgccgtaca gctggtccaa caggggaatc gcgtcgcgct cgaaacgcgc ggtcaactcc 131821 tcgtctgtct cctcagacgg cccaggctgc agacccgccg aaccggttac accatcgatg 131881 tcggccatct tgattaactg ggtcccttcg tttgcggtgt cgccggacag caccggcgcg 131941 gacaccggac gtgcgagcat gcgagccaac cgcttctcac ccaacaggct cgtcgccgtt 132001 gacaccagac tcccctcgtc ccaatgtaga ggccgcgacc gacactgtct gcaccggtct 132061 ggccagccac gtggctgcag gaaccgaacc aatcaaccgt gttcgccagc gggttatttc 132121 cagcgctgaa tcgcatgcgg cctgtcccgc agtccggtgg aatcgagcag ggcgttaggg 132181 tgacgccatg tcactcaacg gcaagaccat gttcatctct ggcgccagtc gcggtatcgg 132241 ccttgcgatc gccaagcggg ccgcgcgcga cggcgccaac attgccttga tcgccaagac 132301 cgccgagccg catccaaagc tgccaggcac ggtgttcacg gccgccaagg aactcgagga 132361 agccggcggc caggcactgc cgatcgtcgg ggatatccgc gacccggatg cggtcgcgtc 132421 cgcggtggcc accaccgtgg agcagttcgg gggcatcgat atctgcgtca acaatgcctc 132481 ggcgatcaac ttagggtcca tcaccgaggt gccaatgaag cgtttcgacc tgatgaacgg 132541 catccaggtg cgtggcacct acgcagtatc ccaagcgtgc attccccata tgaaaggccg 132601 tgagaacccg cacatcctga cgctgtcccc gccgatcctg ctggagaaga agtggctgcg 132661 gccgacggcc tacatgatgg ccaagtacgg catgacgctg tgcgcgctgg gaatcgccga 132721 ggagatgcgc gccgacggca tcgcgtcgaa cacgttgtgg ccacgcacga tggtggccac 132781 cgcggcggta cagaacctgc tgggcggcga cgaggcgatg gcgcggtccc gcaagcccga 132841 ggtatacgcc gacgcggcct acgtcatcgt caacaagccc gccaccgaat acaccggcaa 132901 gacgctgctg tgcgaggacg tgctcgtcga atccggcgtc accgacttgt cggtctacga 132961 ctgcgtccca ggtgcgacgc tcggcgtcga cctgtgggtg gaagacgcca acccgccggg 133021 gtacctcccg gcctagcgac agcaaaaccc tgatcctcga gttgcccgac gagcgggccg 133081 tcgcgatcgt gccggtgccg tcgaagttgt cgctgaaggc ggccggcggc cctaggggtg 133141 cccaaagcgg ccatggctaa acccgctgcc gccgaacaag ccaccggcta cgtggtcggc 133201 ggcatctccc cgttcggtca gcgcaagcgg ctgcggaccg tggtcgatgt gtcggccttg 133261 agctgggacc gggtactgcg gtgccggcaa acggcattgg gccgtcacgg tggccccgcc 133321 ggacctgatc accttgatca gcgcgatcat cgctaacatc cgggcctagc gccgtaccgg 133381 aaatcggcga ggacttcacc gatggcgtag cgcgcgctgg ccgccagcgg cgggttggtg 133441 tcttggtagt acgggagcgc gatcaaggcg atggccagag ctctgccgcg cccgcgcatc 133501 cagtcgtcgt cggcggcgcc gaccgcgacg cggaactgag cacgggcggg cgccgacagg 133561 aggttccacg cgatgatcaa gtcgacgctg gggtcaccga cgcccatcag accgaagtca 133621 atgacgcccg tcaagcgtcc ttgcgctgtc aggatgttga accgggacag gtcaccgtgg 133681 aaccacatcg gcggccccgc atacggagga acgcgtaggg ctgattccca cgcggcagtt 133741 gccgcgtgga cgtcgatgat cccgtcgagg gccgccagcg ctgcgcgtac ctcggcatcc 133801 tgctccccca gcggcgcacc ccgcttggcg ggcggcccgc ccatggggtc ggtggcccgt 133861 aaggcggtga tgaagtcagc caggtcctcg acggcccgat tgggctcgac gaactcggct 133921 gccgacgggt tctcacccgc aacccagcgg cacactgacc acggccaacc gaacccctca 133981 gccgggctcc ccaaccccac cggaactggg ctggcaacgc ctagatgcgc agcgatccgc 134041 ggcagccact gttgctcggt ccgaaggctc tcgatggccc agccaatgcg cgggatgcgc 134101 acggccaggt cctcgcctag ccggtacatt gcgttgtccg tgcccgccga gcgcaccggt 134161 gcaatgggta gatccgccca ctgtgggaat tgtgcacgca gcagacgccg caccagatcc 134221 tcgtcgatat ccacctcatc ggcgtgcatc tttgccctta ggacacgttc gtaccggtcg 134281 aagacggttc cgtcctgctc acagatccgc cgcacgaaag caaagcccgc ccgcaacgcc 134341 accctcgccg atgcggagtt ctccggctcc accttgatca ccgcttcggt cgcgccgtgt 134401 tcggccgcat actggcacac cagatcgact gcgcgagtgg cgagtccacg ccctcgccag 134461 ctggggtaga gcccataggc aacgttgacc tgcccgctag ccagcccctc gccgtcgaaa 134521 cgcagatcaa tcgtacccac tattgtttcg gcaaccgtcc tgatgccgaa agagcgcagc 134581 ggcccgccgg tcacccattg ctcgcggcag tgccggatgt acgcttcgac gcttgctcga 134641 gtcgagggca taccgctaag ccaacgcact agccgttcgt cccccccagc cagatgcgca 134701 tcgacatcgt ccaggcacag tggcgataga gtgacgatcc cgtctgatag cccgtcggac 134761 agcttcgcaa agcgcacccc gcgattgtcg gactcacact ggcttcaggc aaacctgccg 134821 cgagcgcccg gcgagcgtaa tggcgcggca agaaatcgcg cttggattcg ccgcagcgtc 134881 acacgcgtgg gcacagaccc tcacagcagc tggatctgct cgggctgcga cctggccggc 134941 tccaacagct caggcccgtt gttgcgcacg ttgttgacca acgtggacac ttggcgcagc 135001 gcgatgtcgc gcacatccgg cgggcgggcc agcagctcag gatccggcgg ggcgtctgga 135061 ttcagccagt cgtcccagtc ctcttcggcc agcagcagcg gcatccggtc atggatctcg 135121 gccagctcgc ccacggcatc ggtggtgatc accgtgcagc tcagcagcgg tggggcggac 135181 ctgtaagact tccaaaccga ccacagcccg gccgtgaaca acagggcgcc gtcgtggcgg 135241 tgcaggaaga acggcgtctt ggcgttcggc ctccccgggg tggcgtcggg gtcgacgcgc 135301 cattcgtacc agccgtccat cggcaccagg caacgcttac ttctgaccgc actccggaac 135361 gccggcgacg tggcgacctt atcggcgcgg gcgttgatca gcggtgggcc tttggcatcg 135421 ggtgcgccgc cgggcccggc cttgatccac gacggaatca gtccccagcg catgagccgc 135481 acccggcggg tgggctcgtc gtcgggctcg ctgtggcggg acaccactgt cgcgatcgtg 135541 tcggtgggtg ccacgttgta gctcgtcttc ccgccaccgc acccggtggc ctcgtctatg 135601 gccgtgattt tctcggccag ctgggccgga tcagtggtga ccgcaaaccg tccgcacatg 135661 cttcctatgg tgcctggtac ccacgacacc cgccgacacg gcaggatgaa gcggtgaaga 135721 catggccagc cccaacggcg ccgacgccgg tgcgcgctac cgtgaccgtt ccaggctcga 135781 agtcgcagac caaccgggcg ctggtgctag cggcgctggc ggccgcacaa ggccggggcg 135841 catcgaccat ctccggcgcg ctgcgcagcc gcgacaccga actgatgctg gacgcgctgc 135901 agaccctggg cctgcgcgtc gacggtgtgg gttcggaact gacggtcagc ggccgaatcg 135961 aaccggggcc cggcgctcgg gtggactgtg gcttggcggg cacggtgttg cggtttgttc 136021 cgccgctggc ggcgctgggc tccgtcccgg tcaccttcga cggcgatcag caagcccggg 136081 gacggcccat cgcaccgctg ctggatgcgc tgcgcgagct cggcgtcgcc gtcgacggca 136141 ccggtctacc gtttcgggtt cgcggcaacg ggtcgctcgc cggcggcacc gtggccatcg 136201 acgcgtcggc gtcctcacag ttcgtgtccg ggctgctgct gtccgcggca tcgttcaccg 136261 atggcctgac cgtccaacac accggttcgt cgctgccgtc tgcgccgcac atcgcgatga 136321 cggcggcgat gctgcggcaa gccggagtcg acatcgacga ctcgacaccg aaccgttggc 136381 aggtgcgccc cggtccggtg gcggcgcggc gctgggacat cgaaccggac ctgaccaacg 136441 cggtggcttt cctgtcagcg gccgtggtca gcggcggcac cgtgcgcatc accggctggc 136501 ctagagtcag cgtgcaaccc gccgaccaca tcttggcaat tttgcggcag ctcaatgccg 136561 ttgtcattca tgctgattca tccctcgagg tgcgcggtcc aacgggatac gacgggtttg 136621 acgtcgactt gcgcgccgtc ggcgagctga cgccatcggt cgcggcgctg gcggcgctgg 136681 catccccggg atcggtgtcc agactaagcg gcattgccca tctgcggggc cacgaaaccg 136741 accggctcgc cgcgctgagc accgagatca accggttggg gggcacctgc cgggaaacac 136801 ccgacggtct ggtgatcacc gcgacgccgt tgcggcccgg catctggcgg gcatacgcgg 136861 accatcgaat ggcgatggcc ggcgcgatca ttgggctgcg ggtggccgga gtcgaggtcg 136921 acgacatcgc cgccaccacc aagacgctgc cggagtttcc gcggctgtgg gccgagatgg 136981 tcggacccgg ccaggggtgg gggtaccccc agccgcgcag cggccagcgg gcgaggcggg 137041 caaccgggca ggggtccggc ggttgaggcc cggcgactac gacgagtccg acgtcaaggt 137101 gcgctccggc aggagttcgc ggccgcggac caagacccgt cccgagcacg ccgacgcgga 137161 ggccgccatg gtggtcagcg tcgaccgcgg ccgctggggg tgtgtgctgg gcggccgccc 137221 cgatcgccga atcacggcga tgcgcgcccg cgagctcggc cgcaccccga tcgtggtcgg 137281 cgacgacgtg gacgtggtcg gtgacctgtc cgggcggccc gacaccctgg cccgcatcgt 137341 gcggcgagca ccgcgacgaa ccgtgttgcg acgcaccgcc gatgacaccg accccaccga 137401 gcgggtggtg gtcgccaacg ccgaccaact gctgatcgtg gtcgcgctgg cagacccgcc 137461 gccacgcacc ggcctggtcg accgggcgct gatcgccgcc tacgccggcg ggctgacccc 137521 gattctctgc ctgaccaaga ccgacctcgc cccggcggaa ccgttcggca agcagttcgc 137581 cgacctggaa ttgaccgtaa ccgccgcagg cgtcgatgat cctctgctcg cggtggcgga 137641 cctgctggcc ggcaagatca ccgtcctgct cgggcattcc ggggtcggca agtcgacatt 137701 ggtgaatcgt cttgtacccg aagctgatcg ggcggttggt gaggtcaccg agatcggccg 137761 gggacggcac acgtcgactc ggtcggtggc gctgccgttg ggagatacgc tgtccggttc 137821 cggctgggtg attgacaccc caggaatccg ctcattcggg ttggctcata tccagcccga 137881 caacgtgcta ttggctttct ctgacctcgc cgaggcaacc cgcgagtgtc cgcgcgggtg 137941 cgggcacatg ggaccgccgg ccgatcccga atgcgcgttg gataccttgt ccgggcccgc 138001 tgcccgccgc gccgcggccg cccggcgact actggcagtg ctcagccaga cttgactagc 138061 cgcatgctcg tcgcgcgccg agcaatctta ggctgccaga tcgtcgggtt cggtgaccga 138121 cttagccata cgcttgctgc gccgccgacc ccgcacggcg gcaatcgcgg tctttaaccc 138181 ccgacgacgt ccggtcaccg gatcggcgcc cgcgaaaccc ggccccagac cagcgaacat 138241 ccgctcactg cgggtctcgg gtgcatcgtc agcgttgtca cgtaagtact tatccggcaa 138301 cgacagcttg gcaagggtgc gccaggtctt gccgtactgc accaagaacg agcccgtggt 138361 gtatggcaag tcgtatctgt cgcagacctc acgcacccgc accgaaatct cgtgaagccg 138421 gttgctcggc aggtccggat agaggtgatg ctcgatttgg tggcacagat tgccgctcat 138481 gaaccgcagc gccggcccag cgttgaagtt tgcgctgccc agcatctgcc gtaggtacca 138541 ctggcccttc ggctcaccga tcatgtccgt cttggtgaat ttctctgcgc catccgggaa 138601 atggccgcag aagatcaccg cgttggacca cacgttgcgg atcacgttgg ccaccacgtt 138661 ggcggtcaaa gtggaccgat acgtcgcccc cggggacaac gaggtcagcg ccgggaacgc 138721 gacatagtcc ttgaacacct ggcggcccgc tttggctgag aattcacgca accgggtttt 138781 agcggcctcg cggtcggccc gacccttgaa gatcttgccg atctccaagt gctgcagcgc 138841 aactccccac tcgaagccga tcgcaaggat ggtgttccac accacgttga agatgttgta 138901 gcgcttccag cgctggtcac gggtgacgcg cagcatgccg tatccgacgt cgtcatccat 138961 accgaggatg ttggtgtatt tgtggtgcac gaagttgtgg gtgtagcgcc agtgcttgga 139021 cgatccgctc atgtcccact cccacgtcga ggagtgaatc tccgggtcgt tcatccagtc 139081 ccactggccg tgcatgacgt tgtggccgat ctccatgttt tcgatgatct tggccacgcc 139141 aagggtcagg gcacctgtcc accaggcgag gcgtcgtgag ctgccagcca gcagtagccg 139201 accggacacc tcgagcgccc gctgtgcggc gatggtgcgg cggatgtagc gggcatcgcg 139261 ttcgccgcgc gattcttcaa cgtctcggcg gatggcatct agctcggcgg ccaggttttc 139321 aatgtcggcg tccgtcagat gcgcgaatac gtcgacgtca gtgatcgcca tcgtcttctc 139381 cctgcgtcat acggccgatg acctacgcta tcgtaactta cgattccgta ggttacctat 139441 gagtaacact agatgtccag cacgcaatca cccgaggcgg ccgacacgca ggtctggacc 139501 cgggttccgg gctcatgccg ctggcccgtg cgcagatccc gaacatggcc ttccaccagg 139561 tcgaccacac acgactggca gatgcccatc cggcagccga agggtagctg cacgccggcg 139621 ccctcaccgg cgtccatcaa cgacgtggca gcatcggcgg ctacgctctt gccacttcgg 139681 gcgaacgtga cggtcccgcc cgctccagcg ggcgccgttt tggacactgc gaaccgctcc 139741 aggtgcagtc ggtcgctggc acccgccgat gaccagacct tgtcggcctg gttgagcacg 139801 ccctccggcc cgcacgccca ggtctggcgt tcacgccagt ccggcacctg ctgaccgatc 139861 cgggtcaggt ccagccggcc ctgggcgcgc gtctcgcgca ccgacaaccg ataaccggga 139921 tggtcggccg ccagggcagc cagctcggca ccgaacatca cgtcagctgc ggtgggcgcc 139981 gaatgcaggt gcactacgtc ggtgatttgg ttgcggcgca ccaacgttcg aagcatcgac 140041 attaccggcg taatccccga cccggcagtc aaaaacagaa tcaacggggg cgccggatcc 140101 ggtaatacga aattgccctg gggcgcagcc agccgcacaa tggtccctgg ctttaccccg 140161 gccaccaagt gggtggacag gaagccctcg ggcatcgcct tcaccgtgac ggtcaccatg 140221 cgcgcggacc cggatgccgc cggactcgac gtcagcgaat acgaccgcca gcgccagcgc 140281 ccgtcgacca gcagcccgat cccgatgtat tggcccggct ggtagtcgaa actgaagccc 140341 cagcccggtt tgatgaacag ggtcgcggag tcttccgtct ctcggcggac ccctaggatg 140401 cgcccccgca attcccgcgc ggaccacagc ggatttgcca ggtgaaggta gtcgtcgggc 140461 aacaatggcg tcgtgatgcg cgcggcaatc ttgcgcagcg catgccagcc cggatgccgg 140521 tcggctccgg cgacggtggg gcgcctggtg tcgatgatgc tggcgttaag cgtcgtgtgt 140581 ttcttgctca taggaagctc ctgctcggcc ttagcttccg cccaacaaag ctacggtacc 140641 gtaacctacg gttccgtatc taggcccgga cgcgcagact gcgtcacacc cacggcatcg 140701 tcagagcagg tccagcagaa atggcagctc ttggttggcg taccaggcga gatcgtggtc 140761 ctgggcgtca ccgaccacca gctcagcgtc ctcgtcgccc aggtcagcgg catcgatgac 140821 cgcaatcgcc gccatcacgg ccggctcagc gccggcattg tcgacatatg cggcgacaac 140881 ctgatcgatc gtgattggcc ccgccagcct gacgaccgcg tcatcaagat cgggacggta 140941 cgtggcatcg tcgacctcgg cggccagcac cgcgcgtctg ggcggcaggg cgtctgcggt 141001 ggcgccgatg tccgccgcta gcagacgcaa cgacgccaac gccgcttcgc gcagcgccac 141061 ctcggcaagc tcctcgtcgt caccctcggc gtacgactca cgcaacgtcg gcgtcactgc 141121 aaaagcagtg ccgttgaccg gccacaacgc gccatcggca acgagtcgct gcaacatggc 141181 cagggtggcc gggatgtaga cctgcgtcac cgggcgatca acgtggccac atagtcgtcg 141241 acgtatgtcg acaactcgcg gggcggacgc ctgtagttgc cactcacaag cggccgtggc 141301 ggcagcttga cctttggctt ttccacatct gcgtagtcaa tcgtggacag caagtgggcc 141361 atcatgttca gccgcgcgtg ctttttgata tcagactcca ccacgtacca ggggctgacg 141421 ggggtgtcgg tatgcaccat catctcgtcc tttgcgcgcg aatagtcctc ccaccgatac 141481 accgattcca ggtccattgg gctgagcttc cattgccgga ccgggtcatt ccgtcgagcc 141541 ttgaatcggc gcaactgttc ggcgtctgag actgaaaacc agtatttgcg aagcagaatc 141601 ccgtcatcga tcagcatctg ctcgaaaatc ggggtctgcc gcaaaaacaa cacatactcc 141661 tgcggcgtac agaaacccat gaccttctcc acaccggcgc ggttgtacca ggaccgatcg 141721 aagagcacta tctcaccttt ggcgggaaga tgggcaatat aacgctggta gtaccactga 141781 ccccgctcgc gatccgtcgg cgcgggcaat gccgcgatac gagccactcg cgggttgagg 141841 tactcggtga tccgtttgat ggcgccaccc ttaccagctc cgtcacggcc ttcgaagatg 141901 accaccagac gcgcacccga atgccgggcc cactcttgca gcttcacgaa ttctgtttgc 141961 agccgaaaca attcggcttg gtagacggca tcggagatct tgcgccggcc cggcgcagct 142021 gatctgtgtc ccttcgctct cgacgacgcg ccgtcgttgg tcgcggtgct cacatcaacg 142081 gatggtatat ccacacatca ccatcgaccc ctaacaacta ccgcgaagcc tccagaagct 142141 cgtccagtgc ttggctcaac agccccggca gcagatcgac atcgctcatc gcgtcgcggt 142201 cggcattgat gccgaaatac aacatcccgt tatacgacgt cacgctgatg gccagcgcct 142261 ggttgtgcag tagcggcggc acggagtagg tctccagcag cttggtaccc gcaatgtaca 142321 tctgcgactg ggttccgggg gcattggtga tcaacagatt gaacaaccgt gccgaaaagc 142381 tagtggcgac ccgcaccccc atggcgtgca aagtggccgg tgctaacccc gacaacgtga 142441 cgatagtcct ggcatcgacc aggctggcgg cggtcgggtt ggattcggtg gcgtgcgcga 142501 tctgcgacaa ccgcactacg gcattgccct cccccaccgg gaggtcaacc aagaacggtg 142561 tcacctggct gatcgcctga ccagggccgg ttgagtcgag ttggtcgtcg gcatagaccg 142621 acagcggcgc catcgcccga acagtcgcgg tcggtgccac agcttcaccg cgtgacatca 142681 gccagttgcc caaggcaccg gcaatcaccg tcagcaccac gtcgtggagt cacagtcgta 142741 gcgagcccgc accgtgcgat agtcatcaag acttgcacgg gcaaccgtaa atcgccgatt 142801 acgcgacacg gtggcattga gcgggctact gggcgcggtg ccccgtgcca ccgtgcgggc 142861 gatatcgaga accttgcggc ccgtctcgac gagttggccg gaattcgtta ccaacccggc 142921 gaccgcggat ccgacggcct gtagttgtgc gcccggccgc accagccagt ccccgaccgc 142981 gcgcagcagc aaccgcgtgg tgccggggtc ccgttccggg acccagatgt cttccggaaa 143041 cgccggtgga cgccgcgtcc ggtcggcgat cacgtggcct atcgccagcg cggtcacccc 143101 gttgatcagg gcttggtgcg acttggtgta gagggcaatg cgattctttt ccagaccctc 143161 gacgagatac atctcccaca atggccgcga tttgtccagc ggccgagcgg ccagccgtgc 143221 gatcagctcg tgcagttgct cgtcactacc cggcgacggc agggccgacc gccggacgtg 143281 gtaggtgatg tcgaagtcgc gatcgtcgat ccacaccggc ctggccaggc ccaatttcac 143341 ttcctggact ttctgacgat agcgcggtat ctgcggcagc cgctgttcga cggtttccag 143401 cagtgcctcg tagctcaatc cggcacgcgg acggcgcagg atcaacagca acccgacata 143461 cattggggtg gctgtgttct ccagctgata gaaggaggcg tccgatgcag acaaccgggt 143521 gaccactacg gccctgtcct ccttgtcaat tcgtcgcgac gagtcacgtc gtcgcccacg 143581 ctaacggtta gcccgaccac ttcacggcgc gggtacacgc aagcccgcat tgtgcgatga 143641 tggccagcaa ccaaaccgct gcgcaacact cgtctgccac tctccagcag gctcctcgtt 143701 cgatcgatga tgctggaggg tgccccttga ccatcagtcc tatcgcgaac tcaccgggcg 143761 acaccttcgc cgtcacaccc gtcgtcgagt acgagccgcc gccgcgaaac atcccgccgt 143821 gcgggcaatc atcgcacgca gcccggcggc cgcacacccc gcagctagct cgccgacaac 143881 caatcaggcc gagcggccgg gcaccggcag cggtcacctc cacggccaag tcaccgcggc 143941 tgcgtcaagc ggggaccttc gccgatgccg cgctacgccg agtgctggag gtcatcgacc 144001 gccgccgccc ggtgggccag ctgcgccccc tgctggcacc cggcctcgtc gactccgtgc 144061 tcgcggtgag ccgcacggcg gccggacacc aacaaggcgc ggccatgctg cgccgcatcc 144121 ggctgacacc ggccggaccc gacaccgcgg acaccgccgc cgaggtcttc ggcacctaca 144181 gtcgcgggga ccggatccat gcgatcgcct gccgggtgga acaacggccc gccggtaacg 144241 aaacccgatg gctgatggtc gccctgcaca tcgggtgaga tcgccggccc acaccctagt 144301 tcgaagctac tgcggcggcc ggcagcccac cgccggtgta gcgggccagt atcggaccga 144361 cgatcgccat gacgaacaca tacgccgtgg ccaaggcggc aacccccggg atcgaggcac 144421 cggccagccc gatgatgatc aaagaaaact ccccccgggc aacgagcgcg gtgccagcac 144481 gcagctgccc acgccgtgcc actccctccc gccgggcagc gaacatcccg gtggccacct 144541 tggtcgctgc ggtgacagcg gccagggcca gcgctaccgg aagcattgaa acgagctttc 144601 ccgggtcaac cgacaggccg attcccagga agaagatcgt ggcgaacaag tcacgcagcg 144661 gagtcagcac catgcgtgcc cggtctgcgg tctccccggt aagcgtgagg cctaccagaa 144721 acgcacccac agccgccgac gcgtgcagcg actcggccac cgccgccacg atcaaggtga 144781 tgcccagcac ccgcaacaac aattgttcgg aatcaggatg agtcaccaac cggccgacat 144841 gatgacccca acgatacgac gccgcgaacg ccccaagcaa agcggcgatc gccaccgtca 144901 tgcccacgac cgcctcgagc cagctgccgt ctgtcgcgag aaccgcgaac agcggcaagt 144961 aggccgccat cgcgaagtct tcgagcacca gcaccgacag cacagccggc gtttcccggt 145021 tgccgagccg acgcaggtcc tccaacagcc gcgcgatcac acccgaggag gaaatgtagg 145081 tgaccccggc cagaccgagg atggcaacac cgtccaaccc caaaagccag cccgccaccg 145141 caccgggcgt ggcgttgagg acgatatcga cacccgccga cggcaggtgg tggcgcagac 145201 tgctggcgaa ctcggtcgca gaaaactcca gacccagggc caaaagcaac aacacgacac 145261 cgatgggcgc accggtagcg atgaactcac cggcggcggc cacccccaag atgccgccat 145321 tgcctaacga caaacccgcc aacaaataca ccggaatcgg cgacaacgcg aatcgtcgtg 145381 ccactgcacc cagcaccgca agcaccgcca acaggacgcc gagctcaaac aacagcgccc 145441 tcgaaacctc caccggttca gcccttttcg acgatctgtt cgaccccggc gatcccgtcc 145501 tcggtgccga tcacgatgag gacatctccg gctcgcagca catcagtcgg gcccggcgag 145561 gccaacacat cctcgtcacg cacgatcgcc acaatcgacg cgccggtacg ggtgcgcgca 145621 cgggtatcac ccagcggccg gtccacaaac aagctacccg cccggatgtg aatctgaccg 145681 gccttaagcc cgggcacctc acgcgtcagc tcggtaaatc gctcggcgat cctcggcgca 145741 cccagaatct gagccaccgc ctcggcctct tcatcggtga gccgcaaaac cggtcgggct 145801 tcgtccggat catcgcggcc atacaggacg acgtcgaaac cgccactgcg cctggcaacg 145861 atgccgatcc ggtcaccgcg atagctggtg aactcgtatc gcaggcccac ccccggcagc 145921 agcacctcct tgacgtccat aggagtcaat ccttgacgaa atgcggccaa gatagaagcg 145981 gtacgggcaa tctcgttgac tcaggtatgc cggtgcggcc acggcaacaa catcgacacc 146041 tcgcggcggt aatcgcggta ttggtcgccc agcgccgcga gtaggtcgcg ctcttcgaac 146101 tgcaacgcga ccaagatgta gcccgtcgcg ccgatcgcga aaagcaagtg ccccgccgtc 146161 atcatgggcg tcgcccagaa cgcgacgacg aatccgagca tgatcgggtg gcgtacccac 146221 cggtagagca gatgagcctg aaaaccgatc tcggtgtacg gctttccgcg ccaagccaaa 146281 tacacctgcc gtaggccgaa caattcgaaa tgattgatca tgaaagtcga cgtcaacacc 146341 gtggcccacc cgagccagaa caacgcccac aacgccaccc ggccagccgg ctgccgcacg 146401 tcccagatga ccgccggcat cgttcgccat tgccagtaca gcaacaacag cgcaacgctg 146461 gccagcagta cataggtgct gcgctcgatc gagggcggca cgaatcgagt ccaccagcgt 146521 ttgaaaccct gtcgtgccat cacgctatgt tggacggcga acacgcccag cagcaccaag 146581 ttgaccacga ccgcctggcc gatcggcgcc gcgatcgcgt gatctacggt tcgtggcacc 146641 actacgtcgc cgacgaaacc gatcgcatac ccgaaggcaa ccaggaatac cagatagctc 146701 gcggccccgt aaatgatcgt caaataacgc ttcataacct gattctgctc cgcaggagtg 146761 tgcagctggg gcgttcggcc cgattggcgc caatcagcga ttcaacagtg ccatgatgtg 146821 cggcatggcc tcgcgggccg caacgcgtcc cgcctcgcgg gcggcgtcga tctggtgaaa 146881 ctccagcagc ccaacagcac cggtgtcggg tctgataacg acctgcgcaa gactgagtgc 146941 ggcatccgcc ccacgctggc tgccgattgt catcgtgcgc atcaaggtgt cgccgattcc 147001 tggcactttt ggcgagccgt cctgtcgagc cgagcccggc ccgccaccac ctaagccgat 147061 gctcaccgcg atcaatgggc catcaggact tgcccgggtc gagaccggaa ggttgtctaa 147121 cacaccgcca tccacatgca gtcgaccgtt gtagacctgg ggcggataga tgcccggcag 147181 ccgaagggaa cacccaatga catcgacgag tcggcctcgg cggtgtacga ccggtcggcg 147241 ggcaagcaaa tcgacgctaa cgcaacggaa ctcctttggc agctcctcga ccagtcggtc 147301 cccgaacgct gcttctaata gggtcagcgt ccgtcgacca cggactagcc ccctgaccgg 147361 aaacgcgtag tcactgagcg gattgtgccg aatgaagtac tcgtatgcgt aggcgtccgc 147421 tgttgccgcg tccataccgc acgctccgaa caccgcaata accgccccca tgctggtgcc 147481 ggcgaaccgg tcgatggtga ccccgacccg ctctagctcg tcaagaaccc cgaggtgcgc 147541 aaagccgcgc gcgccaccgc cgccgaggac tagaccgatc gagcggccgg cgatgcgtgc 147601 ggcgagcggg cgtacgtttt ccaagatgcg tcggtaatga accacatgaa ccgatcgcgg 147661 cgtgatcaat tcctcccact gacgccggtg ctcccggctg gcggccggac cggccagcac 147721 gaggtcggca ccccgcgcac gcgccggcag ccgcgcggct tgtgggttgg gatctcccgc 147781 gaccagcact atccggtcgg cgacgcgcag gcagaagtcc cgccagccgg catcctcgac 147841 cgcggcatgt agcactacct tgtcggcgac tcgctccgcg cgatcaaggc cgtcgcggtc 147901 gacccggccg gggtcaacgg cacgcaaccg cgccgacagc gcggtaagca ggccagcggc 147961 cactgccggc acgggcgcgt cgccgctcac tccgatcacc gaaacgacca cctcaggcga 148021 cgtcgagtca gtcgccggtg gcggtgcctc ccgcagccgc gttgccagca cctttaccaa 148081 cgccgccagc gcaccatggt cggcgatctc gtcgaactgt gccttggtga gccgcactag 148141 cttggtgtcg cgcaacgccc ggaccgtcgc ggaccggggc gcgtcaataa gtagcccaag 148201 ctccccgaga acctccccgc gacccagttc tttgagaacg atgctgtcct gcagcacctg 148261 cacgcgaccc gtgcggatca cgtaaagcga atcggacggg tcaccttcgt ggaagagata 148321 gcaacccgcc tccaactcga cgtcctcaac gtgctccccg agctgtgcca aggtggccgc 148381 gtccaggccg gcaaatagcg gcagattccc cagcggatcg gcgtcaccgg ccgcccaatg 148441 ctcaatcggc gcggccgccg gctggggaat cggtggctcc aaccgcggcg cgatcgcggg 148501 ctccggcgcc ggcatctgga cggggttgcg gttggttcta cccagcaccg cggccgcgac 148561 agccaccgcg atgaaacaga tggcagccat agcccatccg cgccgcaacg cctcctcggc 148621 agtaccgtgc tccggcttac cgatcaagat caccatcacc gcgacaccga gcaccgcacc 148681 gagctggcga gtggtgctaa cgaccgccga cgaggtggca tagctgccgc ccttggcgac 148741 ctcggccagc gctgcactgc tcaacaccgg caacgtcgcg ccgacaccga tgccctgcag 148801 cagttggccc ggcagccaca cgcggaggaa atccggctcg gacccgacac gctgcaaata 148861 ccacaccagg ctgccggccc agaccagcgc accaacgagg acgatgacgc gatgcccatg 148921 ccgaccggca acccgaccca gcgccgccgc caccacggca gccaccaccg cagcgggcgc 148981 gatcgcgaaa cccgccttca gcagcgagta gtgccacaca tagttgaggt aaagcacatg 149041 ggtaaggcca tagcagtaaa aacccgctgc ggcgaccagc gtgagcaggt tgcccgccac 149101 gaacgaccgg ctacgcaaca gcgccggctc gaccagcggc gcggggtgcg accgcgagct 149161 gtgcacgaac ccaaccgagg tcaggacgct ggccaggaac gaaccgacgg tggccacgct 149221 caaccaaccc cagtccggcc ccttgaccaa accgagggta accaacccga gcgttaccgc 149281 aagcagcagc gcaccgcgca agtcaggcat gcggcgccgg cccgaggcgc ggctctcgac 149341 gagcatgcgc ttggtggcga tcgccgcgac gatgcccagc ggaacattga ccagtaacac 149401 ccaccgccag ccggcccact ccacgaggag cccgccgatc ggcgggccca ggccagccgc 149461 gatcgctgcc gccgcacccc acaggccgat agcgtgcgcg cggcgcgccg cgtcgaagcc 149521 ctcaacgacc agtgcgagcg aagcaggcac gagtatcgca gccccgatgc cctgcagcac 149581 ccggaacgcc accaactgct cgacactgcc ggcgacggcg cacagcccgg acgcaatggt 149641 gaacaccagc acaccggaca ggaatgtccg tctgcggccc agcaaatcgg ccaacctgcc 149701 ggccgcaacc atgaaggcgg cgaagacgat gttatagccg ttcagaatcc aggacaggct 149761 cccgatgtcg taggacggga aggaacgctg gatatccggg aacgcgatgt tgacgattgt 149821 cgagtcgaga aacgccagga aagcgccgaa ccccgctacc agcagaaccg acgccgacga 149881 aggtcggcga cgacgggtga gattagcgaa ccccttgccg ccgtgcaacg aaatgtgcat 149941 gcgcgccggg gcgcggggtg tgccgggaag tgacttctgg gaactgagaa accgatacac 150001 ccatctgcaa cctacgcgct aacgcttctt gaccgatttc ggcggcttgg cgccgcggcc 150061 ttgtcggcgg gcggcttcgc gccgctcgcg ccggctagca ccggccggca ctccggccgg 150121 cgtcttgtgg gctccaccgc cgttgcgctg cacctgagcc gagccatcct ccgcgggacc 150181 ggaataggtc aaagcgggcg actcgctggc aacacccttg gcgcgtaatg cacttggagc 150241 tctttcgcgc gcgccaccat cgaccgcgct gcgttgctgc gcggcggctg cggccgcggc 150301 ggcgaattcg gcaagctctg cgggttcggc agccggggca accggcgggg cggggaccgc 150361 ctccacggtg acgttgaaca ggaagccgac cgattcctct ttcatgccgt cgagcatggc 150421 catgaacatg tcgtagccct cacgctggta ctcgaccaac ggatcgcgct gcgccatcgc 150481 gcgcagcccg ataccctcct tgaggtagtc catctcgtag aggtgttcac gccacttacg 150541 gtctatgacg ttgagcagca cgttgcgttc cagctggcgc atcgcaccct cgccggcgat 150601 ttcctcgagt tcggcttccc gtgcggcata ggcacgttcg gcgtccttga gtagtgcctc 150661 cagcaactcc tcgcgggtga gatcgtcgcg ctcgaattcg tggtccttgc gggtcagcga 150721 gtcggcggtg atccccaccg gatagagggt tttgagtgcc gtccacaacg cgtccagatc 150781 ccaatcttcg gcatagcctt cgccggtcgc gccgtcgacg taggcggtga tgacatcgcg 150841 gaccatgtcc agcgcctggt ccttgaggtt ttcgccttcg aggatgcgcc ggcgctcggc 150901 gtagatgacc ttgcgctgct ggttcatcac ctcgtcgtat ttgaggacgt tcttgcggac 150961 ctcaaagttc tgctgctcga cctgggtctg ggcgctcttg atggcccggg tgaccatctt 151021 ggcttcgatc ggcacgtcgt cgggcaggtt cagcctggtc aacaaggtct ccaaggccgc 151081 gccattgaag cggcgcatca gctcgtcacc cagcgacaaa tagaagcgcg actccccggg 151141 gtccccctgg cggccggacc ggccacgcaa ctggttgtcg atccgccgcg actcgtggcg 151201 ctcggtgccc agcacgtaca ggccgccggc ctcgattact tccttggcct ccttgctggc 151261 ttcctctttg acgatgggca gttcggagtg ccaggccgcc tcgtactcct cgggcgtctc 151321 caccggatcc aggccgcgtt cgcgcagccg ctgatcggtg agaaagtcga cgttgccgcc 151381 cagcacaatg tcggtgccgc gaccggccat gttggtggcg acggtgacgc cgccgcggcg 151441 gcccgccacc gcgatgatgg tcgcctcttg ctcgtggtac ttggcgttga gcacattgtg 151501 cgggatgcgc cgcttggtga actgccgcga cagatactcc gagcgctcca cgctggtggt 151561 gccgatcagc accggctgtc ccttcgcgta gcgctcggcg acgtcgtcga ccaccgcgat 151621 gtacttggcc tcctcggtct tgtagatcag gtcggactgg tcttcacgga tcatcggcat 151681 gttggtcggg atgctgacca cgcccagctt gtagatctcg tgcagctcgg ccgcctccgt 151741 ctgggcggtg ccggtcatgc cggcgagctt gtcgtagagc cggaagtagt tctgcagcgt 151801 gatggtggcc agcgtctggt tctcggcctt gatctcgacg tgctccttgg cctcgatggc 151861 ctggtgcatg ccctcgttgt agcggcggcc gatcagcacc cggccggtga actcgtcgac 151921 gatgagcacc tcaccatcgc ggacgatgta gtccttgtcg cggctgaaca gctctttggc 151981 cttcagagcg ttgttgagat agctgaccaa cggcgagttg gcggcctcgt acaggttgtc 152041 gatgccgagc tggtcttcga cgaattccac acccttctcg tgcacgccga cggtgcgttt 152101 gcgtagatcg acctcgtagt ggacgtcctt ttccatcagc ggcgccaacc gggcgaactc 152161 ggtgtaccag ttggaggcgc cgtcggcggg accggagatg atcagcgggg tgcgggcctc 152221 gtcgatcagg atggaatcga cctcgtcgac aatggcgtaa tggtgcccgc gctgcaccag 152281 atcatccagt gagtgcgcca tgttgtcgcg caggtagtcg aacccaaact cgttattggt 152341 gccgtaggtg atgtcggcgt tataggccac ccggcgttca tcgggtgtca tggtggccaa 152401 aatcaccccg acctgaagcc cgaggaagcg gtgcacgcgg cccatccact cactgtcgcg 152461 tttagccagg tagtcgttga cggtgacgat gtgcacgccg ttgccggcca gcgcattgag 152521 gtaagcgggc aacacacagg tcagggtctt gccttcaccg gtcttcatct cggcaacgtt 152581 gcccaggtgc agggcggccg cacccatcac ctgcacgtcg aacggccgct ggtccagcac 152641 ccgccaggcg gcctcgcggg ccacggcgaa ggcctcgggc aacaggtcgt cgagggtttc 152701 tgggtttttc tggtcggcca gccgccgctt gaactcgtcg gttttcgccc tcagctcggc 152761 gtcggtgagt ttctcgacat cgtcggacaa agtgccgaca tagtcggcca ccttcttgag 152821 gcgcttgacc atgcgacctt cgccaaggcg cagcaacttc gacagcacag ctatgtcccc 152881 gcatgtgtag gagtctttag ataaggcgac tcccatggta ggtgacgacg cggcgcgcgc 152941 cgccgatcac gccagacgga tcaagccgta gtcgtaggcg tgccggcggt agaccaccga 153001 cggccgttcg gtgtccttgt cgtagaacaa gaagaagtcg tgtccaacca gctccatctg 153061 gtagagcgcg tcatcgaccg acatcggctt ggccgggtgt tctttggtgc gaacgatccg 153121 cccaggctcc cgctcgacga cggcaccgtc gtgatcgtgt gcctcggctg gtctggtgtt 153181 gaagccgttc tccggcgctg gcaccaccgc ggtcgcctcg gccagcgaaa ccggggtttt 153241 gtcgccgtag tgcaccttgc ggcgatcctt accgcggcgc agccggctct ccagtttgac 153301 gaccgctgat tcaagcgcgg catagaagct gtcggcgcag gcctcacctc gcaccaccgg 153361 ccctcgccca cgcgcggtga tctccacgcg ctgacaggac ttgcgctggc ggcgattacg 153421 ttcgtggtcg agttcgacgt cgaacaggta gatggtccgg tcgaaccgct ccaagcgggc 153481 gagtttctgc gaaacgtaga tgcggaagtg gtcggggatc tcgacattac ggcccttgaa 153541 cacgatctca gcgtttgatt tcggttcggc cagaacctga cctgaatcca cggctagcct 153601 tgacatacgt gacaactcgt ttctctttcc acgtcacacg cgccctgcgt gcctggcctt 153661 cggggagacg cgccgacggg gtgggagcgg ttggagaagt taccgccgca ggctgcccgc 153721 cggagcaaga tgtcgattgc tcacctccta tcgcgggata ctgattcaac ctgggaagcg 153781 cgagcgtgag tcgttaaagg ttgatctcga cgttagcccg tgttcggctc accgtgccac 153841 caaattgacc gacctgtttc gagttcttca cgttgtcttg gcaactgcac cggctcaggc 153901 agatcctcac gcggccgcga ccgccaacac ggcacccacc cgcacaccgg cggcctgcaa 153961 gacccggacc gactcgcgcg ccgtcgcccc ggtggtgatg atgtcgtcga cgagcacgac 154021 ttcgttgcgc ggccgctggc cccgcaacag cacccgaccc gtgatgttgc gctcgcgcgc 154081 ggacgcccca agacctaccg agtcccgggc tagcgctcgc atccgcagcg ccgggacgac 154141 ggtgacgtca tggtggcgcc caagggtggc acccgcaatc cgcgccatcc ggctgacggg 154201 gtcaccccca cgccgtcgcg ccgcccaccg tctcgtcggc gcaggcacca tcgtcagcgg 154261 gttttcgagc atgccccagg acaacaggtg gtcgacaccg acaatcagcg cgcacgccag 154321 tggcgcgacg aggtcgcgac ggccgtgctc tttcatagcg aggatcgcct gacgacgcac 154381 gcccgcgtag cggccgagcg cgaacaccgg cacctgtggg tcaacacgag gactcaccac 154441 gtgcggttca ccggcagcca ccgacagctc ggcggcacag gcggcacacc agcgggtcgc 154501 cggcgcaccg cagccaccgc attccagcgg caggacgagg tcaagcacac accaagtgtc 154561 gcggtcaccg gtgacagcag tgctgtcaat cggcgccgct gcgcagcggc ggccagacaa 154621 agctgagcgc accctgactc aattgggtaa tcacgctttc cagataacgc agcggcagct 154681 ccgttcgcca ctccggaagc aacgcagaga gctgcaaaca atcggctgcg aggctgacgt 154741 cggtgatgcg cagcccatgc ggcagctcag gcagtggaac tcggtaggcc ggtgtccgtg 154801 ccggcagtgt ccaccgccgt tgtccggtga tcacggtgcg cggtcgcagc cacagtgtcg 154861 tctgggaggt tgtgcccgcc acgtcgacgt cgacctcaag acctccccag tcgggccggc 154921 gcgcccagcg cagccgggcc gctccgctct cggacaactc accgcgcagc tgcggcgtcg 154981 cttgacggag cacatcatcg aaaatctcgg tcggcagggc ggacgacaac tcgacgggag 155041 cggcgatcac cagcggcggc acacccgggc ggatgtgcac gttgcgcagg acggcaacgg 155101 cgctgtgcaa atgatgctga tcccagctga tgccgcgagc ggccacccga acctcgccca 155161 gctggccgac ggccagcccc tgcggttcca gtgccgagtc cagctcggtg acggtcagca 155221 ccacgtcatg gtccccaatc cgaaccgtga cttccttgcc gatgagcagc tgctgcaagg 155281 tggtgaacaa cgtccggtag ggcgccgcaa ctgcctgggc ggctcccgcg ctgaccagcg 155341 acatcccggt cgacgaccac agcgaggcca gcatgtccaa ggcacggaag ggatcatccc 155401 aacgcagccg gggaactctt ggcgacatca acaagcgcct cctcactgcg agggtagccg 155461 gtgtgctcag gtcgcgaaaa acgcaggcac agcactcatc cgggcaatac cggcgccgcc 155521 cccggcacca tcagccccgg tacgtccgcc cagcctggtc ggctttcgac agacgccgag 155581 tacatcaaca ccccttgcgg gccggcgaca tacacagtcg acgggttggc cgcgatcgcc 155641 gtcagtggag tttgcaaccc gcgggacggc gcgtcggagt tcaccccgtc gaggtttaca 155701 taagacaccg gatgggcggc gtcggtgcgt gtcaccacga tgtcgtcacc ggttcgccag 155761 gacaacgaca ccaccgagga acccagcccg aaacccagcc gccgagggta ggtcagggcg 155821 aactggccag cctgggtctg ctcgacgccg gcgaggatca cctgcccacc gatcaccatc 155881 gcggcgcgcg tcccgtcacg ggacagttga agatcgttga tcgcccccgg gaagcggctg 155941 gccaccgcgg tcgaatccac cggaatccgc gcgggttgcc ccgatgccgg gtcctgtatc 156001 gctcgcagca cgacgttggt atcgaccacc acccagaccg cgtcgtccag cgaccagctg 156061 ggccgcgaca ggctgtgccc gtcggcggac tgcaccgcct cgccgccgag gtcgccgacc 156121 cacaaagacg ccgcctcatc cggagccccg cgccccagcg tcaccaccga ggccacctga 156181 cgcccgctgc gtgatacggc ggccgccgtc tgctccggca tccgtccgaa ggccccgggc 156241 acgggggtga ctcgctgtgc gtccatcgcc accagtgatc cgttcaccaa ggcgtgcaac 156301 cccgcggcgg caccgtcggc cacccccggg tcggtggccg cgacatcgga agtggtccac 156361 ccctcggcaa acctgtcttc cagcggggcg ccgtcggcgt tgatcacgta cggccccctg 156421 atgtcggccc tggccaaggt ccagatgatc tgtgcggcaa gtaattgcct gctgtgcgga 156481 tcggtggtgg acagcttctc catgtcgact cgcgcgccgc cgtacccgcg gccgattccg 156541 ctctttccgc cgtcggcccg agtcaccggc ccgcgcagtc gtagcggcgg agcgagcaga 156601 ttacgcaccg tgcgcgccat ctccgggcgt ggacccgcca gcagtttgga gacgagctcc 156661 gtggccagct ggtcgcggtc ggacaccgcg acgtagcgcg gatcgggaac cacggtcttg 156721 ccggtggggt cggcgaagta cagggtgttg cgcttgtacg tttcttggaa ctgctgccag 156781 tccaggaaaa ccccgttggg taggcgatcg atgcgccaac catcggacgt cttgaccaac 156841 tcgatcgggc ccggatccgg cagttgaccc tcggcggtct caaacacccc cacatccgag 156901 agcgagccga gaatgtctgc ccgcatggtc accgaaacct tctcggcgct tcgggtttcg 156961 acgaacacca cgtggtcgat caacaacgcg ctgccggcgt cgtcccaggc gttggaagcc 157021 gattcggtga ggaactgacg cgccgccagg tgccggttgg ccgggtcggc tgtggccttg 157081 aggaactcgc gtaacagcac gtcgggatcc atacccgggc tcggtttggg cagattcgac 157141 ggcaccggac gttcgacggt tccgatggct tgcggggccg acgtgctggg cacactggca 157201 cagccggcca gcactgcacc aaggaacaac aaaattgtca gccgcatcaa ccgctccact 157261 ccgcgtgctc acgtgggcgc tgacgttcct tgtattccgg tggcatcggt tgcggattcg 157321 gttgcgcgac cggttgcaga actggctgcg ggatcggttt catgggcagc gggctggtgg 157381 tgaccttgtg gccgcgcacc atcggaagcg tcagccggaa gcaggcgccc tcgccgggtt 157441 cgccccacgc ctcaagccga ccctggtgca atcgggcatc ctcgacgctg atcgccaaac 157501 ccagcccggt gccgccggac cgacgtaccc gtgagggatc cgagcgccag aaccggctaa 157561 acaccagctt ctcctcacca ggccgcagcc caaccccgta gtcacgcacg gtgacggcga 157621 ccgtgtcttc gtcggcggcc atccggatcc gcaccggttt gtgttcggcg tggtcgatgg 157681 cattggcaat cagattgcgc aggatccgtt ctacccgacg cgcatcgacc tccgcgatca 157741 cctgctcggc gggcagatcc accagcaact cgataccggc ctcctcggcc aggtggccca 157801 cattgccgag cgcgttgttg accgttgtgc gcaagtcgac cgcctcaacc gacaactcgg 157861 ccaccccggc gtcatgccgc gagatctcca gcaggtcgtt gagcaacgtc tcgaatcggt 157921 ccagctcgct aaccatcaac tcggtggacc gccgcagcgt ggggtcgagg tcggcgctgt 157981 ggtcatagat caagtcggcc gccatccgca ccgtggtcag cggcgtacgc agttcgtggc 158041 tgacgtcgga ggtgaaccgg cgctgtaggt tgccgaactc ctccagctgg gcgatctgtc 158101 gggacaggct ctcggccatg tcgttgaacg acaccgccag cctggccatg tcgtcctcgc 158161 cgcgcaccgg catgcgttcg gacagatgtc cctcggcgaa acgttcggcg atccgcgacg 158221 ccgaccgcac cggcaccacc acctgacgcg acaccagcag cgcaatgccg gcgagcagga 158281 ctagcagtac caggccgccg gtggccatcg tgccacgcac cagcgtgatc gtggcttgct 158341 cgctcgccag cggaaagatc aggtatagct ccaggttggc cacccgcgac aacgtcggag 158401 tcccgatgat cagggccggc ccggagaaac cttcggtctg caccgtggcg tactggtagg 158461 cggcctgccc ggccttgacg aagccgcgca gcgcgttggg cacctgatcg acgggtccgg 158521 cagtagaggc agcgcgcggc ccatcacccg gcaccatcag caccgcatcg aacgcaccgg 158581 cgaggccagc ccccgaagcg gggtcggttt tcgacgtcag agtgttgcgc gcaagctgca 158641 ggctactgtc cagtgagcgc gtctcctcac cgttgacgat cccgctgacg gtggtgcgtg 158701 cccgctcgat ctggtcgatc gccgccctga ccttgatgtc gaggacacga ttggtgacct 158761 ggctggtcag cacaaagcca agcgccagga tgacggctag cgacagtcca agggtcagcg 158821 ccacgacccg cagctgcagc gatcggcgcc acgcgacagc tacggctcga ctcaacgcac 158881 tgaggccccg tgtcatcggg ccagagcgac cccggcgacc ccgaatgcgt cggcgcgagc 158941 cgaagatcat cggcgccgct ccttagcatc gctgcgctct gcatcgtcgc cggcgcggat 159001 cacggaggtc cggccttgta ccccactcct cgaacggtca gcaccacagt cgggttctcg 159061 ggatcctttt cgaccttggc ccgcagacgc tggacatgca cgttcaccag cctggtatcg 159121 gctgggtgcc ggtaacccca tacctgttcg agcagcacat cacgagtaaa cacctggcgc 159181 ggcttgcgcg ccaatgcgac caacaggtcg aattccagcg gtgtcaacga gatctgctca 159241 ccgttgcgag tgaccttgtg cgccggtacg tcgatttcta cgtcggcgat ggacagcatc 159301 tcggcgggtt cgtcgtcgtt gcggcgcagc cgcgcccgca cccgcgcaac cagctccttg 159361 ggcttgaacg gcttcatgat gtagtcgtcg gcgcccgact ccagacccag caccacatcc 159421 acggtgtcgg tctttgcggt gagcatcacg atcggaacac cggaatcggc gcgcaacacc 159481 cggcacacgt cgatgccgtt cataccgggc agcatcaaat ccaataacac cagatcgggg 159541 cgcagctcgc gcaccgcggt cagagcctga gtaccgtcgc cgatgaccgc ggtgtcgaag 159601 ccttcccccc gcagcacgat ggtgagcatc tcagccaacg aagcgtcgtc gtcaacgacc 159661 aaaatccttt gcctcatggt gtccatggtg tcaccacatc gggacaaaac tggcgcacca 159721 cacgggcgtt tcttgcttga ttagggcaaa taccctcaac ttggcacgtc tggaggcgcc 159781 aaagtcgccg ctagtcggcc cggatcaaca tcggcgccga caaccagcca ccggccgccc 159841 cacccttggg ccgccaactc ggcgtagacc gcaccggtgc gctgctgaag ttcagcgtcg 159901 cgttcgtaat tgtcgcgcgc ccgaccgggg tcacgctggg cacggccgcg ggatcgttcc 159961 ccggcgagct cggcagagac cgcaaggagc acctgccagt cgggcttggg caacccgagt 160021 cttgcaaatt cgatccgctg aacccaggcc gctgccttcc cggccgcgtt ttcatgtagg 160081 cgcgccgcgc tgtaggccgc gttggaggcg acgtagcgat ccaggatcac cacgtcgtag 160141 ccgcgacaca gcccctggat cgtgtggacc gcgccagcgc ggtcgagcgc gaacagcgtc 160201 gccatcgcat acaccgacga tgcgaggtca ccgtgctcgc cgtgcagcgc ctccgctgcg 160261 atgtcggcgg ccaccgactg tccgtagcgc gggaacgcca gtgtggccac cgatctcccg 160321 gctgctcgaa aggccccgga cagcttttcc accaacgtcc gcttgccagc gccgtcaacg 160381 ccctcaatcg cgattagcac ggcgcggccc tgtcggtggc ggcgcgagca gacgcaaaat 160441 cgcccttttc gtcatgaaaa tgggcgattt tgcgtctgct cgcgggtggg aggcactcag 160501 tagcggtagt ggtccggctt gtagggaccc tcgacgtcga cgccgaggta ttcggcctgc 160561 tccttggtca gcttggtcag gtgaccgcca agggcctcga catggattcg agccaccttc 160621 tcgtcgaggt gcttgggcag ccggtacacc tcgttgtcgt actcgtcgtt cttggtccac 160681 agctcgatct gggcgatcgt ctggttagcg aagctgttgc tcatcacgaa cgaggggtgc 160741 ccggtggcat tgcccaggtt cagcagccgc ccctcggaca gcacgatgat cgagcggccc 160801 gtgtcgccaa aggtccacag gtcgacctga ggcttgacgt tgacccgtgt cgccccggag 160861 cgctccagcc cggccatgtc gatctcgttg tcgaagtggc cgatatttcc caggatcgcg 160921 tggtccttca tcgccttaat gtgctcgagc atgatgatgt ctttgttgcc ggtcgcggtt 160981 acgacgatgt cggcgtcccc gatggcctcc tcgacggtga ccacgtcgaa gccctccatc 161041 atggcctgca gcgcgttgat cgggtcgatc tcggtgacgg agacccgcgc tccctggccc 161101 ttcatcgcct ccgcacagcc cttaccgacg tcgccgtagc cgcagatgag gaccttctta 161161 ccgccgatca gcgcgtcggt gccgcggttg atgccgtcga tcagggagtg ccgagtgccg 161221 tacttgttgt cgaatttgga cttggtcacc gagtcgttga cgttgatcgc cgggaaggcc 161281 agatccccgg ccgcggcgaa ttggtagagc cgcagcacgc cggtggtggt ctcctcggtg 161341 acgcccttga ccgactcggc tatcttggtc cacttgtcct tgtcggtctc gaagcgggtc 161401 cgtagcaggt tcaggaagac cttccactcg gcggggtcgt cctcctcggc gggcggcacc 161461 acgccggcct tctcatactg catgccgcgc agcaccaaca tggtggcgtc accgccgtca 161521 tcgaggatca tgttggccgg cttgtcgggg tccggccagg tgagcatctg ctcggcggcc 161581 caccagtact cttcgagcgt ctcgcccttc cacgcgaaca ccgggacacc cttgggctcg 161641 tcgggggtgc cgtgcgggcc gaccacgacg gcggcggcgg cgtgatcctg ggtggagaag 161701 atgttgcacg aggcccagcg gacttcggcg cccagcgcgg tgagggtttc gatcaacacc 161761 gcggtctgca ccgtcatgtg cagcgaaccc gagatccggg cccccttcag gggttgcacc 161821 tcggcatact cgcgccgcag cgacatcagg ccgggcatct cgtgctcggc gatccggagt 161881 tctttgcggc cgaaatccgc tagtgacagg tcggcgatct taaagtcgat gccgttacga 161941 acgtcagggg tcagcgaatt tttggtcacc aaatttccgg tcataggggc tttcatcctt 162001 ctttgggggc tcacagggat ccgagcgggc tacttagcct aggtacgctc ttgcagtcac 162061 tgtagccgcc gtcggtcagc cccgcaggtc aggggacatt gatcacaccg tgacgctccg 162121 cgaacggcgt tattagccgt gctaggtccg ctgcgacatc atggtcggcc tcgggcggca 162181 tcgacacgta gctcaagcac agccgcacga tcgcacgcga gagcacattg gcgtcgttat 162241 cggtggtggc cacccaggta tcggtgaagg ccggcgccag ccgggccgac gcgcgggtga 162301 tgatcggcgc gctgtcggtg gtgatcagtt gcagcagatc gggcttggcg acaccggtca 162361 acagcgagat gaccaacgga tctgccgccg actcggcgaa gaacgaccga aagccctgca 162421 ggaacgcttc gtaaaagttg ccgacgttgg cgtccaacga tgcatggacg ttgtccacta 162481 atcggtcggc caggcgcagc gcgtatccct gcgccaggcc ttgccgggaa ccgaattcgt 162541 tgtagatggt ctgccggctg atgcccgccg cgcgggccac gtcggacagc gtgatggcgg 162601 accagtcgcg ggtcagcagc agatcccgca tcgcatccag caccgaatcc cgcaacaggg 162661 cccgcgaggc ctcggcatag ggtatccgct tcacaggcgc gacagtagcg cttggagtgc 162721 tcacgagcga gccacctcca ccatctcgaa atccgacttt gccgcaccgc aatccgggca 162781 actccagtca tcggggatgt cgtcccagcg ggtgccggcc gcgatgccgt cctccggcca 162841 acccagcgcc tcatcgtact caaagccgca ttggatacag cggaacagtt tgtagtcgtt 162901 cacttagtta ccctcctatc ttttcgaaat cgaccttctc gcgcaccgcg cagtccgggc 162961 agcaccagtc gtcgggaatt tgatcccagc ctgtgccggc tgggaagcct tccctggcat 163021 caccgttggc ctcgtcgtag acgtagtcgc agaccgggca ccggtaggcg gccatcatgc 163081 cgaggctccg taacgggcga gtgccttctc ccgcacgcgc gggtgcaggt taacccgagt 163141 gatatcgccg ccgtagtgct ccagcacccg gtgatccatt accttgcgcc acaacggcgg 163201 gaagtaggtc agcgagatca tcgatgcata cccactgggc aggttgggcg cacccgccat 163261 gctccgcagt gtctgatagc ggcgagtggg gttggcgtgg tgatcgctgt gtcgctgcag 163321 gtggtagagg aacaggttgg tgacgatgtg gtcggagttc cagctgtgca ccggggcgca 163381 gcgctcgtag cggccgttgg cgctcttctg ccgtagcagt ccgtagtgtt cgaggtagtt 163441 gacggcctct aacaggctga agccgaagac tgcctggatg atgacgaacg ggatcagcgc 163501 cgggccgaag accgcgatca gcccacccca caacaccacc gacatcagcc acgcgttgag 163561 cacgtcgttg cgcagatacg tcatgggatt ccaggggctg acgccgagcc gacgcagccg 163621 ttgggcctcc aaatgaacgg ccgagcgcaa gccgccgata acactgcggg gcaggaactc 163681 ccacaacgtc tcgccgaacc gcgccgacgc cgggtcctcc ggtgtggaca cccggacgtg 163741 atggccacgg ttgtgctcga tgtagaagtg cccgtagcag gtctgggcga gggtgatctt 163801 ggacagccac cgctccagcg aatccttctt gtgccccatt tcgtgggcgg tgttgatacc 163861 gacgccgcca agcacaccga ccgacagcgc caccccaagc ttgcccgccc agctcaaggc 163921 gccgtcaaag ccgagccaac tgaggtttgc ggcggtgaac aggtatgcgc ccagcaccac 163981 gctgaggtac tggaacggga tgtagatgta ggtgcagtag cggtagtact tgtcattctc 164041 cagccggtcg gtcacctcgt cgggcgggtt ctgcccgtcg ggcccgaagc gtaggtcaag 164101 aagcggcaac aagacgtaga gcaggatcgg tccgatccac agcggcacct gcgcggcggc 164161 gtgccagccg agctggttca tcccccagat cagcggcagc atcaccacca aggccgtcgg 164221 ggcgatgagg cccataagcc acaggtaacg cttcttgtcc cgccactcct cgacttcggg 164281 cggccggggg gcttcgggtc caccagagcc gatttgcgtg gtcatatgcc aaacctcctc 164341 atgagccaca ccacgttggg atttgacaat agagcagttt gcgtcttatg tctagacata 164401 taacgcaatt tgtaaatacg cggcgaagct agttcaacac ctccgggtcg cgctctctcg 164461 agcttgccga aggccctgcg ccgagtgccg gcgcccgtag ccgacataaa tcgcggttcc 164521 ggccaccagc cagatcccga accggatcca agtcaacgcg gtgaggttca gcatcagcca 164581 caggcacgcg cacactgcgg cgatcggaag taacggcacc cacggagctg tgaacccccg 164641 ctgaaggtcg ggtcgggtcc ggcgcagcac gaccactccg gccgagacga ggatgaacgc 164701 gaacagtgtc ccgacgttga ccatctcctc aagcttggtg atcggaaaca ccgacgccgt 164761 cgtggccacc aacaccgcga ccagcaccgt gacccggacc ggggtgccgc gcgaaccggt 164821 cttggccaat tgccgcggca ccaagccgtc gcgcgccatg gcgaacagca cgcggcattg 164881 cccgagcatc aacaccatca ccaccgtggt aagcccggcc agcgcgccga cggagatgat 164941 gccgctggcc cagtacaccc cgttggcctg gaacgcggtg gccagatttg ccggcccgcg 165001 gcccggtacg gtccgcagtt gggtgtatgg aaccatgccc gacagcacca ccgataccgc 165061 gacgtagaga agggtcacga cccccagcga cgcgagaatc cctcgaggga cgtctcgttg 165121 aggacgcttg gtctcctcgg ccatggtggc cacgatgtca aacccgataa acgcgaagaa 165181 cacgatcgat gccccggcca gcacgccgta ccatccgtag tggctgcctt gggctccggt 165241 cagcaacgag aagacggatt gatcgagccc gccgccgtgg tgctggactt cgggctcggg 165301 aatgaacggc gagtagttgg cggccctgat gtagaaggca ccgacgacca ccaccaagac 165361 gaccaccgac accttgattg cggtgaccac cgcggaaaat ctcgacgaca atttggtgcc 165421 caacgcgatc agggtcgcca ccaacgtgac gatcacgagc gcaccccagt cgagctgcag 165481 cgatccgaga tggcctgtgc cattaccgaa tccgaacacg gtgcccaagt agctggacca 165541 gcctttggcg accacggccg cacccatcgc cagttccagc accagattcc agccgatcac 165601 ccaggccaag aactccccga aggtggcata agagaaggta taggcgctgc cggccaccgg 165661 cagcgtcgag gcgaactcgg cgtagcacag cgcggccagc gcacaggtcg ccgccgcgat 165721 cagaaacgat atccagatgg ccgggccggt gatatcgcca gcggtcgacg cggtaaccgt 165781 gaatattccg gcgccaatca ccaccgagac gccgaaaaca accaggtccc accaggtgag 165841 gtccttgcgc agccgagtgg tgggctcgtc ggtgtcggcg attgactgtt ctaccgactt 165901 catgcgccgt cgaccggcca tgcacccgtc ctctcgcact cgttgtgacc gcacagtact 165961 gggtactctg cgaggatgac gggtcgcgta gggaacccga aggaccacgc cgtggtgatc 166021 ggagctagca tcgccgggtt gtgcgccgcg cgggtgctct cggacttcta ctccacggtg 166081 acggttttcg agcgcgacga gttgccggaa gcgccggcga accgggccac ggtccctcaa 166141 gaccgacacc tgcacatgtt gatggcccgc ggggcgcagg aattcgacag cctgttcccc 166201 ggcctgttgc acgacatggt ggccgcgggc gtgcccatgc ttgagaaccg gccggactgt 166261 atctacttgg gcgccgccgg ccatgtcctc gggacggggc ataccctgcg caaggagttc 166321 accgcctacg tgcccagccg gccgcacctg gaatggcagc tgcggcgacg ggtcctgcag 166381 ctctccaacg tccagattgt gcggcgcctg gtcaccgagc cacagttcga gcgcaggcag 166441 cagcgagtgg tcggcgtgct gctggattcc cctggtagcg gccaagatcg ggaacgcgaa 166501 gagttcatag ctgccgacct tgtcgtcgac gcagccggcc ggggtacccg actgccggtt 166561 tggttgacgc agtggggata tcggcggccg gccgaagaca ccgtggacat cggcatcagc 166621 tatgccagcc accaatttcg cattcccgac gggctgatcg ccgagaaggt ggtggtcgcc 166681 ggcgcctcac acgatcagtc gctggggcta ggcatgctgt gctacgagga cggcacctgg 166741 gtcctcacca ccttcggggt ggccgatgcc aaaccgccgc cgactttcga cgagatgcgt 166801 gcactcgcgg acaaactgct gccggcccgc ttcaccgccg cgctggcgca agcccaaccg 166861 atcggctgtc cggcgtttca tgctttccca gccagcagat ggcgtcgcta cgacaagctg 166921 gaacgtttcc cgcgcggaat cgtcccgttc ggcgatgcgg tggccagctt caatcccacc 166981 ttcgggcagg gcatgacgat gacctcactg caagccggcc acctacgacg ggcgctcaaa 167041 gcccgcaact cagctatgaa aggcgacctg gccgccgaac tcaatcgggc caccgccaag 167101 accacctatc cggtgtggat gatgaacgca atcggcgaca tcagtttcca ccacgccacc 167161 gctgagcccc ttccccgatg gtggcgccca gccggttcgc tgttcgacca attcctcggg 167221 gccgcagaaa ccgatcctgt tctcgccgaa tggtttctgc gacggttttc gctgctggac 167281 agcctgtaca tggtgccgtc ggtaccgatc atcggtcgcg ccattgctca caatctgcga 167341 ttgtggctaa aagagcagcg tgagcgtcgg caacccgtca caacccgacg gtcgccctga 167401 acagcttggc gggttggccg gcggtcagcc ggatcgggcc gtcgtcggcc gccacccagg 167461 cggccgtgcc gcgctgtagc gtgagcgacc cgcacttccc gtgcaccgtc gccgaaccct 167521 cggtgcataa caagatctgt ggaccgtcat ggccggacga cgcgtcgacc tcgtggccga 167581 ggtgatcgcc gtcgagcacc agtagcgtgg ccgcgaactc atcggtgggc gtctcaaaga 167641 ccagccccag cccctcgcgc cggatcgggg gccgcagccg agccttcggc gtgggggcga 167701 agtccagcac ccgcaacaac tcgggcacat cgacgtgctt aggggtaagt ccaccgcgta 167761 acacgttgtc ggagttggcc atcacttcca caccgaaacc acgcacatag gcgtgcaggt 167821 tgccggccgg caggaagatc gcctccccag gagccaagct gatgcggttg agcaacaacg 167881 ccgccagcac accggcgtcg ccgggataac gttcgccgag ttccagcact gtcttggctt 167941 cggcgccaaa ttccgttgcg ccggagctga cgtactggat agcgccgtcc agcacggcag 168001 gcaccagcac gtcgatgtcg ggctggggtg cggtaatcca ggtggtgaac agcgcacgca 168061 aaccatcggc atcggacccc tcgctcagca agtcgatgaa cgggtcgagg tcggatacgg 168121 ccagcgcccg cagcagctcg gtggtgcgag ccgcctcccg gaatccggcc agcgcctcga 168181 acggctgcag cgccaccaat aactctggct tgtgactggt gtcgcggtag ttgcggacgg 168241 gtgaggacac cggaatgccc attcgctctt cccgcaggta gccctcaacc gcctgctcgg 168301 cgctcggatg ggcctgcaac gatagtggct cgtcggccgc caacaccttg accaagaacg 168361 gcaacacatc gccgaatcgc gcgcgcgacg cggagccgag ctgcccctcc ggatccgcga 168421 ccaacgcttc gagcaacgag gtttggccat gcggcgtctg cagccaagcc ggatcacccg 168481 ggtgtgcacc gaaccatagt tcggcctcgg ggtgagcggc cggcaccgga cgcccggtga 168541 attcggcgat agcggtgcgc gatccccaag cgtaggtgcg taacgcgcca cgtagcagtt 168601 ccaccggcga tctatcctcg caccagtcgc agatacacgg cggccatctc cagccgaacg 168661 gccaataccg cccccccgga tcccacgggg gcgtcgagca gctccggcac atcctcagcc 168721 gcgaccagat aggcgtcatc gagcccggca acccgagcgg ccaccaccgt ccgctcgccg 168781 gccagcgcca gcgccaacac ccgcagccgc tgcggtgccg gcccatcgat ttcctcgtca 168841 tggaacagcg catccggcgg cgtcccggca cgtagcgcca caaccgcatc cgaaagcctg 168901 gtagcggcca caacctggtt tgcgatccgc agcatgaccg aactcccatg ccgggccagc 168961 gccagcgtcg cggcattgtc tccagccagg gccagctggc aaccggaaac gcgagcggca 169021 agtgccttgg ccgggttggt gaacacctct cggccggcgc tgttgcggag cgcctcagca 169081 tccagctcgt ctgccagcga cgccagatcg atgcgcagct tgggatccac ggtttgcaag 169141 gccgccagac ccgcggccag gtaccgggac aacccgaact cgtcaggaac ccgcagccgc 169201 ggttccagca ccgcgacgcg accggccgtg ctgtcccgca gcggaccctc atacggtgcc 169261 accacgacaa cccgcgcgcc cctgcgcacc ccgatcgcgg cggccccgac cagcgccggg 169321 tcgccggggt cgtcgccggc aacgatcagc acgtcaagcg gcccgaccca gggcggcgcc 169381 gcactggcga gcacgatcgg ctcggcggcc ccggcaccta gcgtcgaggc caggatggtc 169441 ccggcggtct cagcggtccc ccggccggtc acccagatca ccgagcgggg acggtcacta 169501 ccgcgcagca agtccagttc gccctcgtcg gccgcggcag cgatggcacg cacctgtgcg 169561 ccggccatcg atgcggcccg cagcagggca ccccggtcgg cagcgatcag gccttcggtg 169621 tcctcgagat cgatcgcccg ggcgacgttc acggtccggc cttcgcatgt gcgctctggg 169681 cagcgatttc agcgctgacc tgacgtacca ccgcgtcaac gtccccgacg ctgcggccct 169741 ccacattgag ccgcagcaac ggctcggtgt ttgagctgcg caggttgaac cagctgtcgt 169801 cgcctaagtc aacggtcacg ccatcgaggt gatcaatact gacaatccgg ttgccgaacg 169861 atttcaacac ggcctccaca caggccgaag agtcgaccac ggtgaagttg atctcgccgg 169921 aggattcata gcgttggtag tccgcggtca actccgacag cggtctgctc tgctcaccga 169981 gggcggccag cacatgcagt gcggccagca ttccggaatc ggcaccccag aagtcacgga 170041 agtaatagtg cgccgaatgt tcaccaccga aaatcgcccc ggtctcggcc atcagtgcct 170101 tgatatagga gtgcccaacc cgcgaacgca gcggcgtacc gccgcgctcg gcgaccagct 170161 cgggcaccgc gcgggaggtg atcacgttgt ggatgatggt ggcgccgatc tcccggttga 170221 gttcccgcgc ggccaccaat gcggtaaccg tcgacggcga gaccggctgg ccgcgttcgt 170281 cgaccacgaa gcagcggtcg gcgtcgccgt cgaaagcaag cccgatatcg gcgccggtgt 170341 cacgcacata ggcctgcaga tccaccaggt tcgccgggtc cagcggattg gcctcgtgat 170401 tgggaaacga tccgtcgagc tcaaaatacg agggcaacaa ggtgatcgag tcgatcaccc 170461 caaggaccgc cggcgcggtg tgaccggcca tgccgttgcc ggcgtccacg gccacccgca 170521 acggacgtag ccccgaggtg tccaccagcg atcgcaggaa cgccccgtag tcgaccagca 170581 cgtcctggtc ggcaatggtt ccgggcgtcc cgtcgtatcg tgcgacgccg gcgatcaggt 170641 cgtcacggat ggcggtcagc ccggtatcgg ctccgactgg tttggcggcg gcccgacaca 170701 tcttgatgcc gttgtatgcc gccgggttgt ggctcgcggt gaacatcgct cccgggcagt 170761 ccaacagccc cgaggcgaaa taaagctgat cggtggacgc caaaccaact cgcaccacgt 170821 cgaggccctg cccggtcacc ccggccgcga acgcgtcggc cagcgacggc gaactgtccc 170881 gcatgtcgtg accgatcacc actggtcgcg catcctcggt ccgcatcaac cgcgcgaatg 170941 cggcgccgag atcggtaacc agcgactcgt cgatctcttc gccgaccagc ccgcgtacgt 171001 cgtaagcctt gataacgcgg tccacagccg cggcgggcca agacatgcgc gggctcctga 171061 caacctagat tttctgcgac tcttggccgc cagcctatcg gcccgcgaac gacgcgggcc 171121 gaatcggtct cgaacagcat gggaagacta gtcggcgggg tcgggcaaca cccgtagatg 171181 tccgcgccgg cgcccggccc caggctcggg cggcgcaagc acgccacccc cggtgggcgc 171241 tccggtcgcc gcagcgggaa aatcgtcgaa accatgcagt ggcgcgccat ttccgcctgg 171301 atgatgccgg cgccccgcgc tcgggccacc ctcgcgcacc gcgtccgcca gggccaccag 171361 gtcgtcctcg tcggggtggc tgggcagcgg cccggcgtga cgcacgagtt cccacccgcg 171421 cggtgcagtg atgcgaccgg catggccgac acacagatcc cacgaatggg gctcccgcgc 171481 agtggcaagc ggaccgatca ccgccgtcga gtccgagtag acgaacgtca acgtcgccac 171541 tgcatagtgc ggacacccgg gccggcagca gcgacggggt acgttcacga ccgaaaggct 171601 atcgtgcacc aacgccgccg aagcgccgga cacgcgcatc cgtccacgcc gcgatgttta 171661 accgttacca tcggcgcgtg agcgattccc gcagctcctc gtggagccgt cggtcgcggg 171721 gcgggtcggt agcgcggcga gcaatccggc ggggccgcga gatgcgcggg ccactgctgc 171781 cgccgacagt cccggggtgg cgcagccggg ccgagcggtt cgacatggca gtgctggaag 171841 cctacgaacc catcgagcga cgctggcagg agcgggtgtc gcagctggac atcgcggtcg 171901 acgagatccc gaggatcgca gccaaagatc ccgaaagtgt gcagtggccg ccggaagtca 171961 tcgccgacgg accgatcgcg ctggcccggc tcatcccggc cggcgtggac gtccgcggaa 172021 atgcgacgcg cgcgcgaatc gtcttgtttc gcaaaccaat tgaacgacgg gccaaggaca 172081 ccgaggaact tggtgaattg ctgcacgaaa tcctggtggc ccaggtggcc atctacctgg 172141 acgtcgaccc atccgtcatc gacccgacga tcgacgacta gttcgcgccg ccgactccgg 172201 cggccgggtc agatgatccc gcgtttgagg cggcggcgct cgcgttcgga aagaccaccc 172261 cagatgccga accgctcgtc atgagccagg gcgtactcca gacactcgtg ccgcacctcg 172321 cagcccatgc aaatcttctt ggcctcacgc gtggagccgc ccttctccgg gaagaacgct 172381 tcgggatccg tttgcgcaca tagcgcacgg tcctgccatt ggtcggtggc ttccggcggc 172441 agaggttcct cgaatggcgc cggcgcctcg ggaaccaaac tcagatgcgg tcgcaaaact 172501 gccgttgctg atgcggtagc cgatccggta gtggtatgcg gtgtgcctcc cattacaccc 172561 cgaaggtgtt cataggacat gcctccgcct cctcactcga tagatagtga aatggtttcc 172621 cactgttttg atgtacagtt aacccaattc gaacaagtga tcgaatctcg gtctgcgaca 172681 ccgaaaccgg ccggccaacc gcgaaatgac actgatgtga ttagacacaa gttggggacg 172741 cgggtcaagt gtgccggcgc atttccatat catctcgtaa taaaatttcc gcggttctgt 172801 tgtggttggg tcccggcgtg tcgagcgtga ctcgtaacca acgtttggtg atgggcgccg 172861 ggaggtactg tcctgcgatg tgaaggtcac cgttctggcc ggtggagtcg gcggcgcccg 172921 cttcctgctc ggggtccagc agctgctcgg cctgggccag tttgctgcca attctgccca 172981 ctcggacgcc gaccaccaac tgagcgctgt cgtcaacgtc ggcgacgacg cctggatcca 173041 cgggctgcgt gtctgcccgg atctggacac ctgcatgtat accctgggcg gcggggtgga 173101 cccccagcgc ggctggggcc agcgtgacga aacttggcac gccatgcagg aactggtgcg 173161 ctatggcgtg cagcccgact ggttcgagct cggggaccgc gatctggcca cccatctggt 173221 gcgcacccag atgctgcagg ccggctaccc cctgtcacag atcaccgagg ccctatgcga 173281 tcgctggcaa ccgggcgccc gcttgctgcc tgccaccgac gaccgttgcg aaacccatgt 173341 agtgatcacc gacccggtcg acgaaagccg caaggcgatc cattttcagg agtggtgggt 173401 gcgctaccgt gcccaggtgc cgacgcacag ctttgctttt gtcggcgctg aaaagtccag 173461 cgctgcaacc gaagcgatcg ccgccctggc cgacgccgac atcatcatgc tggcgccgtc 173521 taatccggtg gtcagcatcg gcgccatcct ggccgtcccc gggattcgcg cggcgttgcg 173581 ggaagcaacc gcaccgatcg tcggctactc gccgatcatc ggcgaaaagc cgttgcgcgg 173641 catggccgat acgtgccttt cggttatcgg ggtggattcc accgcggccg ctgtgggccg 173701 gcactacggc gcgcggtgcg ccaccgggat actggactgc tggctggtgc acgacggcga 173761 ccacgctgag attgacgggg tgacggtgcg gtcggtgccg ctgctgatga ccgacccgaa 173821 cgcgacggct gagatggttc gcgccgggtg cgaccttgcg ggagtggtag cttgaccggc 173881 cccgaacatg gctccgcctc gaccatcgag atcctgcccg tcatcgggct gcccgaattc 173941 cgtcccggcg acgatctgag cgccgccgtc gccgcggcgg caccgtggct acgcgacggt 174001 gacgtcgtgg tggttaccag caaggtggtg tccaaatgcg agggccggct ggttccggct 174061 cccgaagacc ccgagcaaag agaccgattg cgccgcaagc tgatcgagga tgaggcagtg 174121 cgcgtgttgg cgcgcaagga ccgcacgttg atcaccgaga atcgactcgg gctggttcag 174181 gcggccgccg gcgtggacgg atccaacgtc ggccggtccg agttagcgct gctgccggtc 174241 gatcctgacg ccagtgccgc aaccttgcgc gccgggctgc gcgagcggct cggcgtcacc 174301 gtcgccgtgg tcatcaccga caccatggga cgcgcctggc gcaacggcca gaccgatgcc 174361 gcagtcggcg ctgccggtct ggcggtgctg cgcaactatg ccggtgtccg cgacccatac 174421 ggcaatgagt tggtggtcac cgaggtcgca gtcgccgacg agatcgccgc ggccgccgac 174481 ttggtcaaag gcaaactgac cgcgacgccg gtggcggtgg tgcgtgggtt cggcgtgtcc 174541 gacgacggct cgacagcccg gcaactgctg cggccgggcg ccaacgacct gttctggctc 174601 gggaccgccg aagcgctcga gctgggtcgc cagcaagccc aactgttgcg caggtccgtt 174661 cgccggttta gcaccgatcc ggtgccgggc gacctcgtcg aggctgcggt cgccgaggcc 174721 ctcaccgcgc cagccccaca tcacacccgg ccgacccgat tcgtgtggct gcagacaccg 174781 gccatccgcg cgcggctgct agatcggatg aaagacaagt ggcggtctga tctcaccagt 174841 gacggcttgc ccgccgacgc gatagaacgc cgggtggcac gcggccagat cctctatgac 174901 gcacccgaag tcgtcatacc gatgctggtg cccgacggag cacacagcta ccccgatgcc 174961 gcccgcaccg acgccgagca caccatgttc acggtcgccg tcggagcggc cgtacaagcc 175021 ttgctggtcg cgctggccgt gcgcgggctg ggcagttgct ggatcggctc gacgatcttt 175081 gccgctgacc tggtccgcga cgagctggac ctgccagtcg actgggagcc gttgggcgcc 175141 atcgcgatcg gatatgccga cgagccgtcc gggttgcgcg acccggtgcc tgccgccgat 175201 ttgctgatcc tgaagtgaca ttcgctctag cgacgatagg ctacccagac atggcggtcc 175261 tgcagccgat gccaaccatc aacctcccga cggatcaatt caccgcgttc ggtcaaaagt 175321 ggctcctcgg ctcgaaattc tccaagaagg acgacaggac ttaggcgccg tgatagatgc 175381 cgctgtgggc ggcgcactgt cggtgatgct cggcaacatc ccattggtgg ttccgaacgc 175441 caaccagctg taaccttccc aagcgccgac gtgtaccgct gctatccggc ccgattccag 175501 ggacagccac cccatgcaac ctagtcatcc gacgcgccct ggtgcggtca tcagatatgt 175561 cggtagctcc cttgatactt gtcccatgac gacgttcgcc ggcaaaacgg ctgcgtccgc 175621 tgacaaggtg cgcgggggct actacacgcc gccggcggtg gcccgattcc ttgcccactg 175681 ggttcaccag gcggggccga agatcctcga accatcctgc ggcgatggcc gaatcctgcg 175741 cgaactctcc gccatcacag accacgcgca cggtgtggaa ctcgttgcgc gcgaggcgaa 175801 aaagtcgcgg gacttcgcgt ccgtcgacac tgagaacctt tttacctggc tgcacaagac 175861 ccaactcggc agctgggatg gcgttgccgg caacccgccc tacatccgct tcggaaactg 175921 ggcatccgaa caacgggatc cggcactcga attgatgcgg cgtgtgggcc tacgaccgac 175981 caaactgacc aatgcctggg tcccgtttgt cgtggcgagc acgacgctag cgcgtgacgg 176041 cggccgagtg ggcctggtgg tcccggcgga attgcttcaa gtcacctacg cggcgcagct 176101 acgcgaattc ctgctgagcc gctatcggga gatcaccctg gttaccttcg agcggctggt 176161 gttcgacgga atcctgcagg aagttgtgct gttctgcggc gtcgtcggtc ccggtcctgc 176221 acacatacgc accgtcaggc tcggcgatgc gaacgatctg aacgcgctgg gggacaagga 176281 cttcaccaat gagtcagcgc cggcgcttct ccacgaaaag gagaagtgga ccaagtactt 176341 cctcgacccc gctcaaatcc ggctactgcg aggactcaaa cagtccgcca ctatgatcag 176401 gctcggcgaa ctggccgacg tggatgtggg catcgtgacc ggccgcaaca gcttcttcac 176461 gttcaccgat gccaaggcac aagcgctggg attgcgagcg cactgcgttc ccctggtctc 176521 tcgcagcgcc caactcagcg ggctgatcta tgacgaggat tgccgggcat gcgatgtcgc 176581 cggcaaccac cgaacgtggc tactcgacgc cgcggactat ccaaccgatc cagctctcgt 176641 cgctcacatc accgcgggtg aagcggccgg cgtccacctc ggctacaagt gctcgatccg 176701 caagccatgg tggagcacac catcgctgtg gatgcccgac ctctttatgc tgcgccagat 176761 ccacttcgcc ccgcggctga ccgtcaacgc tgccgcggcg accagcaccg ataccgtgca 176821 ccgggtccgg ctcgacccga acgtcgatcc ggcaactctt gccgcggtgt tccacaacag 176881 cgcgacattc gcgttcgccg agatcatggg ccgcagttat gggggcggca tcttggagtt 176941 ggagcctagg gaagccgagc aactacctat gccaccgccg gcgtacggga gcgcagaact 177001 tgcccaggat gttgatctcc tgctgaaagc aaacgagatc gacaaggcgc tcgacgtcgt 177061 ggaccgtcac gttctgatcg acgggctcgg cttgtcgccg cgcctggtcg caggttgccg 177121 agcggcatgg ctcacgctcc gcgaccgcag gaccaagcgc ggatctcggc gataaccgcg 177181 gcgggtgagc gcctcgcgtg cccggccaac gatgtcgatc tcggcgcaag aagctcaaac 177241 gtcggacgag taacggatcc cgccgtcggg aagaaagaca ccgggccata cccgggcacc 177301 acttaacaac tcgcagcgcg cgccgatgtc ggccccgtca ccgatcacac cgtcgcggat 177361 caacgcccgc ggtccgatgc gagcaccgaa gccgatgatc gaacgctcga tcacgcaccc 177421 ggcctccacc cggacaccat cgaagatgac cgcgccgtcc aatctggtgc cggggccgat 177481 ttcggcacca cgccccacga cggtgccgcc aatcagcaac gcaccgggag ataccgccgc 177541 accgtcgtgc accaactgct caccgcggtg accacgcaag gccggagacg gggcgatgcc 177601 gcgcaccaga tccgccgatc cgcgaacgaa gtcttccggt gtgcccatgt cccgccaata 177661 gctggcatcg acatagccgt agatcttgca gtcgccgtcg gcgagcaagg ccgggaacac 177721 ctcgcgttcc accgaaacct cccggccctg cggaatccgg tcgatgacgt tgcgttcgaa 177781 gacatagcag ccggcattga tctggtcggt cggcggatcc tccgtcttct ccagaaaggc 177841 gactacgcgg tcctcctcgt cggtgggtac gcagccgaat gcccgcgggt cgcccacccg 177901 caccagttgc agcgtgacat cggctcgatt gcttcggtgg aagtccagca gttgggccag 177961 atccgcgccc gagagcacat cgccgttaaa caccatcgcg gtgtcgttgc gcagcttgcc 178021 ggcaacgttg gcgatgccgc cgccagtccc caagggatgc tcctcggtca cgtattcgat 178081 ctgtaggccc agtgcggacc cgtcgccgaa ctccgcttcg aagactgcgg gtttgtagga 178141 cgtacccagg atcacgtgct cgatgcccgc tgcggcgatc cgcgacagca gatgggtgag 178201 gaacggcagt ccggcggtag gcagcattgg cttgggcgcc gacagcgtca acggccgcag 178261 tcgggtaccc ttgccaccga ccaggaccac cgcatcgact tggtgagttg ccaactcagt 178321 gccgcccttc taccagcttc agtttccgtc tgcgggacct gcgcagtgaa ctgcgcacca 178381 tgaggtggga acgcagcgcc agtgatcccc gcagggtcca gcgcagcgga gcccgccacc 178441 aaccagaatg tcggtcggct aagaagatat aggtgctttt gtgatgggcg gccagatggc 178501 ttgccgggtc gcgacccgtc gaatgcgcct tgtggtgcag aacctcggct gacggcacat 178561 acaccgacag ccaaccggct ttgccaagcc ggtcgccaag gtcgacgtcc tccatgtaca 178621 tgaagtaacg ttcgtcgaat ccgccgacct ggccaaacgc cgaccggcgc accagtaggc 178681 aagaccccga caaccaaccc accggccgtt cactgggctc cagccgctcc tgccggtagg 178741 ccgtcgtcca cggattgcgc ggccagaacg gcccgagcac tgcgtgcatg ccgccgcgga 178801 tcaggctggg catctgccgc gccgacgggt acaccgaccc gtcggggtcc cgaatcagcg 178861 ggcccagcgc gcccgcgcgg ggccagcggg aggcggcgtc cagtagtgca tcgatactgc 178921 ccgggcccca ttgcacgtcc gggttggcca cgatcaccca gtcatcgacc cagggttcgc 178981 cggcatcgcc cgccatttca ccgagctggg cgatcgtccg attcaccgcg gttccgtacc 179041 cgaggttggc ccctgtgggc agcagccgca cgttggggta gcgctgcacc gcggcctgcg 179101 gggtgccgtc ggtggagccg ttgtctgcca acagcacgct gaccggccgc tcggtggcca 179161 gcgacaacga cgccaggaac cgctctagat ggggccccgg cgagtaggtc accgctacca 179221 ccggcaggac gtcagtcacg cgttgagggt aaccgtcgat cgatcgaagt tgagttcgca 179281 ggtgctgcca gcgccgtggc cagtgcgctg cgccagtgcc gtagcggcgt caagcccgcc 179341 agcgcccact gcctgctcga cagcgcggaa tagctcgaac gcggcgcggg ccgcggaaac 179401 tgcgcgctgc tgaccggacg cacccgctgt gggtcggcac cgcattcttc gaacaccgcg 179461 cgggcttgac cgaaccggga gaccacgccc tcgttagcgg cgtgcaacac gcgtccgcgc 179521 acgcccgcgt cggccaacgc cagcagcgcc tcggccaggt cggcgacgta ggtcggcgac 179581 ccggtctggt cgtcgaccac atccacccga ccgtgtccgg cggccagccg gcgcatgacg 179641 gcgacgaaat ccttgccggt cccgccggtg tagacccagg cggtccgtac cacggcagcc 179701 tccgggaacg ctgccagcac agcctgctcg ccggcgagtt tgctgcgggc atacacgccc 179761 tgcggcgcgg tttcatcggt gggctcgtag ggccggggct cggcgccgcc gaagtcgcca 179821 tcgaatacgt agtcggtgga gacgtggatt aaccgagcac ccacacgagc gcacgcacgg 179881 gcgaggtgtt gcgggccagt ggcattgacc gcataggcga ctgcctcatt gctctcggcg 179941 ccgtcgacgt cggtgtaggc ggcgcaattg atcaccacgt caccgtgtcg gatgatccgc 180001 tcggccgcag cggggtcggt gatatcccac tgcgaggaag tcagcgccag catatcgcgg 180061 ccttcccggg cggcctgtgc cgtcagatgg ctgcccagct gcccgcccgc accggtgatg 180121 actagccttt ctgacctgcc cgccatgtgt ttgagtctgg cacgcctcgg gcacgccggg 180181 gttggctacc cgacagggcg ccgttacaca agtagtctag tgtgatgtct gcgcaacgtg 180241 tggttcgtac ggttcgtacc gctcgggcta tttccacggc actggccgtc gcgatcgtcc 180301 ttggcaccgg ggtggcgtgg agcagtgtcc ggtcgttcga agacggcatc ttccacatgt 180361 cggcgccctc gctggggcac ggcggcgacg acggcgcgat cgacattttg ctggtcggcc 180421 tggacagccg taccgacgcg cacggcaacc cgttgagcgc cgaggaattg gcgacattgc 180481 acgccggcga cgaggaagcc accaacaccg acaccatcat cctgatccgg gtacccaaca 180541 acggaaagtc ggcgaccgca atctctatac cgcgggactc ctacgtcgcg gctcccggtc 180601 tgggtaagac caagatcaac ggcgtctacg ggcaaaccag agagaccaag cgggccggcc 180661 tggtccaagc cggtgcctcg ccgaccgaag cggccgccgc cggcaccgag gccgggcgtg 180721 aggcgttgat caagacggtc gccgatctga ccggcgtcac cgtcgaccac tacgccgaga 180781 tcgggctgct cggtttcgcg ttgatcgccg acgcactcgg cggcgtcgac gtctgcctca 180841 aagagcctgt atacgaacca ctttcgggtg ccgattttcc agccgggcgg caaaagctca 180901 acggtccgca agcgctcagc ttcgttcgcc agcggcatga tctgccccgc ggcgacctgg 180961 accgggtggt acgtcagcag gcggtgatgg cggcgttggc ccaccgggtc atctccggac 181021 agacgctatc cagccccgcc acgctgaagc ggttggagca ggccgtgcag cgctcggtgg 181081 tgctgtcctc cgggtgggac atcatggatt tcgtccgcca attgcagaag ctggccggcg 181141 gtaacgttgc cttcgccacc atcccggtgc tcgacggcgc cggctggagc gacgacggca 181201 tgcaaagcgt ggtgcgggtg gatccgcgtc aggtgcagga ctgggtcgtc ggcctgctgc 181261 acgagcagga ccagggcaag accgacgagc tggcctacac acccgccaag accacggcca 181321 acgtggtcaa cgacaccgat atcaacgggc ttgcggcagc ggtgtcaaag gtgttgagct 181381 ccaaggggtt taccaccgga tccgtcggca acaacgacgg cgaccacgtg cctggcagcc 181441 aggtgcgggc cgcaaaggcc gacgacctgg gcgcacagca ggtcgccaag gaactgggcg 181501 ggttgccggt ggtcgccgat gcgtcaatcg cgcctgggtc ggtgcgggtg gtgctggcca 181561 acgactacag cggtccgggc tccgggctgg ggggtagtga tccgaacggc gtcgtatcgc 181621 cggcccgcgc gttcaacctc gggtccgccg acgacacgac tcccccgccg tcgccaatcc 181681 ttaccgccgg ctccgacgcg ccggagtgca tcaactgacc acaccgacca ccctgagcgg 181741 ggcgatcctg gatccgatgc tgcgcgccga cccggtcggc ccgcgcatca cctactatga 181801 cgatgccacc ggtgagcgca tcgagctatc cgcggtgaca ctggctaact gggccgccaa 181861 gaccggcaac ctgttgcgcg acgagctggc ggccggaccc gccagccgag tcgcgatcct 181921 attaccggcc cattggcaga ccgcggcggt gttgttcggc gtgtggtgga tcggtgcgca 181981 agcgatactc gacgattctc ccgccgatgt ggcactgtgc accgccgacc gtctggccga 182041 agccgacgcc gtcgtcaaca gcgcggcggt agccggcgag gtagccgtgc tgtcgctgga 182101 tccattcggt cgaccggcaa ccggcctgcc ggtcggcgtc accgactatg cgaccgcggt 182161 gcgggtacac ggcgaccaga tagttcccga acacaacccc ggtccggtgc ttgccggtag 182221 atccgtcgag cagatcctgc gcgactgcgc ggcgtccgcg gccgccaggg gtttgacggc 182281 ggcggatcgg gtgctgtcca ccgcttcctg ggccggaccc gatgagttgg tggacggcct 182341 gctggcgatc ctggccgccg gtgcgtcgtt ggtgcaggtg gccaatcccg atccggcgat 182401 gctgcagcgc aggattgcga ccgaaaaggt cacccgcgtc ctgtgacgca ggccgcgtcc 182461 agcaggcgaa ggcatcagag caatacatat tgatatcgcg atatatagat gttaatgtca 182521 ctgcaacgag ctgccgctgc aattacagac ccggaagaaa ggtacaggca atggcgatac 182581 aagtgttctt ggcgaaggcg acaacgacgg tgatcaccgg cttggccggc gtgaccgcct 182641 acgagatctt aaaaaaggcc gcggccaaag cgccgcttcg tcagaccgcg gtatcggcag 182701 cagcgctggg tctgcgcgga acccgcaagg ccgaggaagc cgcggaatcg gcccgcctaa 182761 aggtggccga cgtgatggcc gaggctcgtg agcgcatcgg cgaggaatcg cccactccag 182821 cgatcagcga cctgcacgac cacgaccact gagcgcctcg ccatgaccct ggaagtggta 182881 tcggacgcgg ccggacgcat gcgggtcaaa gtcgactggg tccgttgcga ttcccggcgc 182941 gcggtcgcgg tcgaagaggc cgttgccaag cagaacggtg tgcgcgtcgt gcacgcctac 183001 ccgcgcaccg ggtccgtggt cgtgtggtat tcacccagac gcgccgaccg cgcggcggtg 183061 ctggcggcga tcaagggcgc cgcgcacgtc gccgccgaac tgatccccgc gcgtgcgccg 183121 cactcggccg agatccgcaa caccgacgtg ctccggatgg tcatcggcgg ggtggcactg 183181 gccttgctcg gggtgcgccg ctacgtgttc gcgcggccac cgctgctcgg aaccaccggg 183241 cggacggtgg ccaccggtgt caccattttc accgggtatc cgttcctgcg tggcgcgctg 183301 cgctcgctgc gctccggaaa ggccggcacc gatgccctgg tctccgcggc gacggtggca 183361 agcctcatcc tgcgcgagaa cgtggtcgca ctcaccgtcc tgtggttgct caacatcggt 183421 gagtacctgc aggatctgac gctgcggcgg acccggcggg ccatctcgga gctgctgcgc 183481 ggcaaccagg acacggcctg ggtgcgcctc accgatcctt ctgcaggctc cgacgcggcc 183541 accgaaatcc aggtcccgat cgacaccgtg cagatcggtg acgaggtggt ggtccacgag 183601 cacgtcgcga taccggtcga cggtgaggtg gtcgacggcg aagcgatcgt caatcagtcc 183661 gcgatcaccg gggaaaacct gccggtcagc gtcgtggtcg gaacgcgcgt gcacgccggt 183721 tcggtcgtgg tgcgcggacg cgtggtggtg cgcgcccacg cggtaggcaa ccaaaccacc 183781 atcggtcgca tcattagcag ggtcgaagag gctcagctcg accgggcacc catccagacg 183841 gtgggcgaga acttctcccg ccgcttcgtt cccacctcgt tcatcgtctc ggccatcgcg 183901 ttgctgatca ccggcgacgt gcggcgcgcg atgaccatgt tgttgatcgc atgcccgtgc 183961 gcggtgggac tgtccacccc gaccgcgatc agcgcagcga tcggcaacgg cgcgcgccgt 184021 ggcatcctga tcaagggcgg atcccacctc gagcaggcgg gccgcgtcga cgccatcgtg 184081 ttcgacaaga ccgggacgtt gaccgtgggc cgccccgtgg tcaccaatat cgttgccatg 184141 cataaagatt gggagcccga gcaagtgctg gcctatgccg ccagctcgga gatccactca 184201 cgtcatccgc tggccgaggc ggtgatccgc tcgacggagg aacgccgcat cagcatccca 184261 ccacacgagg agtgcgaggt gctggtcggc ctgggcatgc ggacctgggc cgacggtcgg 184321 accctgctgc tgggcagtcc gtcgttgctg cgcgccgaaa aagttcgggt gtccaagaag 184381 gcgtcggagt gggtcgacaa gctgcgccgc caggcggaga ccccgctgct gctcgcggtg 184441 gacggcacgc tggtcggcct gatcagcctg cgcgacgagg tgcgtccgga ggcggcccag 184501 gtgctgacga agctgcgggc caatgggatt cgccggatcg tcatgctcac cggcgaccac 184561 ccggagatcg cccaggttgt cgccgacgaa ctggggattg atgagtggcg cgccgaggtc 184621 atgccggagg acaagctcgc ggcggtgcgc gagctgcagg acgacggcta cgtcgtcggg 184681 atggtcggcg acggcatcaa cgacgccccg gcgctggccg ccgccgatat cgggatcgcc 184741 atgggccttg ccggaaccga cgtcgccgtc gagaccgccg atgtcgcgct ggccaacgac 184801 gacctgcacc gcctgctcga cgttggggac ctgggcgagc gggcagtgga tgtaatccgg 184861 cagaactacg gcatgtccat cgccgtcaac gcggccgggc tgctgatcgg cgcgggcggt 184921 gcgctctcgc cggtgctggc ggcgatcctg cacaacgcgt cgtcggtggc ggtggtggcc 184981 aacagttccc ggttgatccg ctaccgcctg gaccgctagc agccgcagcc gtgaccacgc 185041 caggtgcgga tgccctgcca gaccgcgata ccggcgatgg ccagcccgat cgcggggtca 185101 atccaccagc cgttcgacca cacggcagtg atcgccagcc caagcagaac cgcggcggcc 185161 tgagcagcac acaggtagtt ctgggtgccc tcgcccgcgg tggcccccga tcccagccgc 185221 tcacccactc ggtggttggc ccagcccagg accggcatca gcagcagggc gatggccgtc 185281 agtccgatgc cgatcaccga ggtctcggca cgatgctcgc cggctaggtg gcggatggat 185341 tcggcaacga ggtagggggc cgtcagccaa aaagacaccg caactccacg ctgtgcgcgg 185401 tgctccgcgg tcgcggacca agtgcggtcg ccggtgaacc gccagagcac catcgcgctg 185461 gccaggccct cggatccgcc acccagcgcc cacccggtca acgcgacgga tccgaccgca 185521 ataccctgcc acagccccac ggcaccttcg gtgagcaata ccgccaggct gacccacgcc 185581 agccagcggg cccaccgaac gttccgctgc cattcggcct ctcgcgccac cgacacgggc 185641 gaatccagcg tggattcatc gcggtgttcc gtcgtcgtct ccatcccgac gatggtagag 185701 gcaagacatg ccgggcggtc gccgcggcgt cgcgaacccg tatggttcag ggaggatgcc 185761 gcacgccagg gaaggtcacc accgatgccg accagcaacc ccgccaaacc acttgacggg 185821 tttcgggtat tggatttcac ccagaacgtg gccgggccgc tggccgggca ggtgctggtc 185881 gacctggggg ctgaagtcat caaggtggag gcgcccggcg gtgaagcggc ccgtcagatc 185941 acctcggtgt tacccggacg cccgcccctg gccacctact ttctgcccaa caatcgtggc 186001 aagaagtcgg tgacggtgga cctaaccacc gagcaggcca agcagcagat gctgcggctc 186061 gcggacaccg ccgacgttgt cttggaggcg tttcggcccg gcaccatgga aaagctgggc 186121 ctaggccctg atgacttgcg ctctcgtaac cccaacctga tctacgcgcg cctaaccgct 186181 tacggcggca acggcccgca cggcagccgg ccgggaatcg acctggtggt ggccgccgag 186241 gccggcatga ccaccggaat gcccacgcct gagggcaagc cacagatcat cccatttcag 186301 ctcgtcgaca acgccagcgg tcacgtgctg gcccaggccg tgctggccgc gctgctgcac 186361 cgcgagcgga acggggtggc cgacgtcgtc caggtcgcga tgtacgacgt cgcggtggga 186421 ctacaagcca accagctgat gatgcatctc aatcgggccg ctagcgacca gccgaagcct 186481 gaaccggcac cgaaggccaa gcggcgcaag ggagtcggct tcgctaccca gccatcggac 186541 gcgtttcgca ccgccgatgg gtacatcgtc atcagcgcat atgtgcccaa acactggcag 186601 aagctgtgct acctcatcgg ccggcctgac ctcgttgaag atcaacgatt tgccgaacaa 186661 cgctcccggt cgatcaacta cgccgagttg accgccgagt tggaattggc actggccagc 186721 aagaccgcca ccgaatgggt ccagttgctg caggcaaacg gcctcatggc ctgcctcgcc 186781 catacctgga aacaggtcgt cgacaccccc cttttcgccg agaacgacct caccctggaa 186841 gtcggtcgcg gggcggacac catcacggtg atccgcacac cggcgcgcta cgccagcttc 186901 cgcgcggtcg tcaccgatcc cccgcccacc gccggcgaac acaatgccgt gtttctggcc 186961 cggccctgac gctgtgacca ttccgaggag tcaacacatg agcaccgcag tcaacagctg 187021 caccgaggcg cccgcatcgc gatcacagtg gatgctggct aatctgcggc acgatgttcc 187081 cgcatcactt gtcgtcttcc ttgttgcgtt gccactttcg ctggggatcg cgatcgcctc 187141 cggggccccg ataatcgccg gtgtgatcgc cgccgtcgta ggcggcattg tcgccggggc 187201 ggtcggtggg tcgccggttc aggtcagcgg cccggccgcg ggtctgaccg tggtggtcgc 187261 cgagctgatc gatgagctcg gttggccgat gctgtgtctg atgacgatcg ccgcgggtgc 187321 actgcagatc gtgttcggcc taagtcggat ggcgcgcgcc gcgctggcca tcgccccggt 187381 cgtggtgcac gccatgctgg ccggcatcgg tatcaccatc gcgctgcagc aaattcatgt 187441 tctgctcggt ggtacgtcgc acagctcggc gtggcggaac atcgtagcgt tgccggacgg 187501 catcctccat cacgaactgc acgaagtgat cgtcggcggg acggttatcg cgatcctgtt 187561 gatgtggtca aagctgcccg ccaaggtgcg tatcattccc ggcccactgg tagccatcgc 187621 gggcgcgacc gtgcttgcgt tgctacccgt gctacaaacc gaacgaatcg acctgcaggg 187681 caacttcttc gacgcgattg gcttgcccaa acttgccgaa atgtccccgg gaggacagcc 187741 gtggtctcat gagatcagcg ccatcgcgct cggtgtcctc accattgcgc tgatcgcaag 187801 cgtcgaatcg ctgctgtcgg cggtcggtgt cgacaagctg catcacggcc cgcgcaccga 187861 cttcaaccgg gagatggtcg ggcagggcag cgcgaacgtg gtgtccggat tgctcggcgg 187921 gctgcccatc accggtgtca tcgtgcgcag ctcggccaac gtggccgccg gcgcccgaac 187981 ccggatgtcg acgatcctgc acggagtgtg gatcctgctg tttgcgtcac tgttcaccaa 188041 cctggtggaa ctgattccca aggcggcgct ggccggcctg ctcatcgtga tcggtgccca 188101 gctggtcaag ctggcgcaca tcaaactagc ttggcgcaca ggaaatttcg taatctacgc 188161 catcaccatc gtgtgtgtgg tgttcctcaa tctgctggaa ggcgtggcca tcgggctggt 188221 cgtggcgatc gtattcctgt tggtgcgggt ggtacgcgcg cccgtcgagg tcaagccggt 188281 cggcggcgag cagtccaagc gatggcgggt cgatatcgac ggcacgttga gcttcctgct 188341 gctgccccgc ctgaccacgg tgctctcgaa gctgccggaa gggtcggagg tgacgttaaa 188401 cctgaacgca gactacatcg acgactccgt ttccgaggcc atctccgatt ggcggcgcgc 188461 ccacgagacg aggggcggag tggtagcgat cgtggaaacg tcgccggcca aactgcacca 188521 cgcacacgcc cgaccaccga agcgccactt cgcgtctgat ccgattggac tggttccgtg 188581 gcgatcagcg cgcggcaaag accgcggcag cgcttcggtt ctcgaccgca tcgacgagta 188641 tcaccgcaat ggcgcggccg tgctgcaccc gcatatcgcc gggctgaccg attcacagga 188701 cccgtatgag ctgttcctca cctgtgccga ctcgcggatt ctgccgaacg tcatcaccgc 188761 cagcggcccc ggcgacctgt acaccgtccg caacctcggc aacctggtgc cgaccgatcc 188821 ggacgaccga tcggttgacg cggcactcga cttcgccgtc aaccagctcg gcgtcagctc 188881 ggttgtcgtc tgcggacatt cgtcgtgtgc tgcgatgacg gcgctcctgg aagacgaccc 188941 ggccaacacg acgactccca tgatgcgttg gctcgagaat gcccacgaca gcctggtggt 189001 gttccgcaat caccacccgg cacgccgcag cgccgaatcc gccggttacc ccgaagccga 189061 ccagctgagc atcgtaaacg ttgccgttca ggtggaaagg ctgacccgcc acccgatctt 189121 ggcgaccgcg gtcgccgctg ctgatctaca ggtcatcggc atattcttcg acatctcgac 189181 cgcccgggta tacgaggtgg gtccgaacgg catcatctgc ccggacgagc cggccgaccg 189241 ccccgtcgac cacgaatcag cgcagtagcg cccgcgacat cactacccgc tgaatctgat 189301 tggtgccctc atagatctgg gtgatcttgg cgtcgcgcat aaaccgctcg accgggaagt 189361 cggtggtgta gccggcgccg ccgaacagtt gtacggcatc ggtggtgacc tccatcgcga 189421 cgtcggaggc gaagcacttc gaggccgccg aaatgaagcc cagatccggc tcaccgcgtt 189481 cggcgcgggc ggcggcggag taaaccatca gccgagccgc ctccaccttc atcgccatgt 189541 cggccagcat gaactgcacg gcctgaaacg tactgatcga ctcaccgaac tgcttgcggt 189601 ccttggtgta ggcgatggca gcatccagcg cgccctgggc gatacccacg gcctgcgcgc 189661 caatcgtggg acgggtgtgg tccaacgtgg ccagcgcggt cttgaaaccg gtaccgggct 189721 caccgatgat gcgatcgccg gggatgcggc agttctcgaa gtacagctcg gtggtcggtg 189781 accccttgat cccgagcttg cgttctttcg gaccgacggt gaacccctcg tcgtccttgt 189841 gcaccatgaa cgccgagatg ccgttggcgc cccggtcggg atcggtcacc gccatcaccg 189901 tgtaccaggt cgacttgccg ccgttggtga tccagcactt ggcgccgttg agaatccagt 189961 gatccccatc ggccttggcc cgcgtccgca tggacgccgc gtcactgccg gcctcgcgtt 190021 cactcaatgc ataggaagcc atcgcccctt cggcggccaa cgccggcagc acctgcttct 190081 tcagctcctc ggagccccgc aggatcaggc ccatggtgcc cagcttgttg accgcgggga 190141 tcaacgacgc ggacgcgtcg acgcgggcca cctcttcgat cacgatgcag gtagctaccg 190201 agtcggcacc ctgaccgccg tactcctccg gaatgtggac ggcgttgaaa ccggaggaat 190261 tgagcgccac tagcgcttct tcggggaacc gcgccttctc gtccacctcg gcggcatgcg 190321 gagcgatctc cttttccgcc aaagcccgta tcgccgatcg catttcgtcg tgttcctcgg 190381 gcagcttgaa cagatcgaac gacgggtttc cggcccatcc aaccatcttg gagccctcct 190441 aatctccgtg ctagtcgcgg gttaacttac ccgcaagccg ctgcagttcc gcatccttgg 190501 ccgccacgac gtcggccagc cggtcctgga atgcgacgat ccgggccctc agctgggggt 190561 tggcggctcc cagcatccgc accgccagca gtccggcatt accggcgccc ccgatggaca 190621 ccgtggccac cggaaccccg gccggcattt gcacgatcga cagcagggag tcaaggccgt 190681 ccagcctgcc cagcggtacc ggcaccccga tcaccggcag cggcgtcgcg gcggcgacca 190741 taccgggcaa gtgcgcggcc ccgcccgctc cggcgatgat cacctcgaga ccgcgctcgg 190801 ccgcgccgcg cgcataactg aacatcgcct caggggtgcg atgggccgaa acaacccgaa 190861 cctcggccgg aatgtcgaac tcggccagcg ccgccgcagc gtcggccatc accggccagt 190921 cgctgtcgct gcccatgatc accccgaccc ggggccgctc gccggcagga gtcataggcg 190981 ccgctcctcc tcatcgcttc gtcccccgca cgcgggtggt acccccactg catcgtcgct 191041 ggcgcggtgt gggtcccatc cgtcagtcca ccgcccatgg gacaaccagt gtgccgccag 191101 ctcagcgcgt tcacacaact gggcgacatc ggagccaagg aagttgatat gccccacctt 191161 gcgaccgggt cgctcggcct tgccgtagag gtgaacccgg gcgtcgggca ttcgcgcaaa 191221 cagatggtgc agccgctcgt cgacgctcat ggccggcggc tgcgcggcgc cgagcacatt 191281 ggccatcacc gtcacgggca ccacggcgtc gctgtcgccg agcgggtagt ccaagaccgc 191341 gcgcagatgc tgctcgaact ggctggtgcg cgccccgtcg atggtccagt gcccggaatt 191401 atgtggccgc atcgcgagct cgttgaccag caacgccccg tcggtcgtct cgaacagctc 191461 gacggcgagc acgccgacca caccgagttc gtcggccagc tgcaacgcca accgttgcgc 191521 cgcggtggcc aggtcgtcgg gcagcgccgg cgccggcgcg atcaccagca cacacgtgcc 191581 gtcacgttgc accgtctgga ccaccggcca cgccgcaccc tggccgaacg gcgaacgcgc 191641 caccagtgcc gacagctcgc ggcgcaggtc cacccgttcc tcgaccagca ccgccacgcc 191701 gtcagccagg cattcgcgag cgaaatcacg ggcatccgcc acatcacgtg ccatccgaac 191761 gccccggccg tcgtaacccc cgcgcactgc cttgaccacg atcggggcgt cgacacgtgc 191821 ggcgaagacg tcgatttcgt cggggtcttt gatgcccgcg tagcggggca cggcgacgcc 191881 tgctgcagcc agacgctgcc gcatgacgag tttgtcctgg gcgtgcacca gcgcctgcgg 191941 cgacggtgcg acattgacgc catcggcgac tagcttctcc aacagctcgt tcgggacgtg 192001 ctcgtggtca aaggtcagca cgtcggcgcc ggccgcaacg cggcgcaagg cggcaagatc 192061 ggtgtgcgag ccgatcacca cgttgggggt gacctgcgcg gcagggtcat ctgccgaggt 192121 gaccaataca cggaggttct gccccagcgc gatggcagcc tgatgggtca tccgggccag 192181 ctgaccgcca ccgaccatcg caacgagggg ggcaatgaac gaggtgaccg ccggggtgcg 192241 tgagctcgcc acggccatca tggtgtcacg gcatctgacc ggcgtacttg ccggccacgg 192301 cagccaaacc gttacgtatc attttgcgtc gattttgtgt tcgtccgtac actcacttgt 192361 tgtgtccttt gccgatgcca ccatcgcgcg ccttcccggg gtggtccagc cctatgcgca 192421 gcgccaccat gagctgatca aatttgccat cgtcggcggc accacattca tcatcgacac 192481 agcaattttc tacaccctca agctgacggt tctcgaaccc aagccggtga ccgcgaaggt 192541 gatcgccggc atcgtcgccg tcatcgcgtc ctacgtgttg aacagggagt ggagcttccg 192601 cgaccgcggc ggtcgcgagc gccaccatga ggcgctgctg ttctttgcgt tcagcggcgt 192661 gggagtgctg ctgagcatgg cgccgttgtg gttttccagc tacatcctgc agctacgggt 192721 gccaacggtg tcactgacca tggaaaacat cgccgacttc atctcggcct acattattgg 192781 caacttgctg caaatggcgt tccgcttctg ggcgtttcgg cgctgggtgt tccccgacga 192841 gttcgcccgc aaccccgaca aggccctgga atccgccctt accgcgggcg gcatcgccga 192901 agtcttcgag gacgtcttgg agggcggctt cgaggacggc aacgtcaccc tgctgcgggc 192961 ctggcgtaac cgggccaacc ggttcgctca gctgggcgac tcgtcggagc ccagggtgtc 193021 gaaaacctcg tgatacagca acgcatgcac ctcccgcagg cgcggaatgt tgtagaactc 193081 gagcggatct tgtgacgcgg actcgataat caacgtcccg gtgcgaaaaa tccgctcgaa 193141 gatccggtcc cggaactcca cgctgttgat ccgtgctagc ggtatgtcga tcccgctgcg 193201 ggtcagcaca ccatgccgga acatcacccg ccggttggtc accacgaaat gtgtggtcag 193261 ccagctcagg aatggccaca gcgtgagcca gccgacgatc accaaccaga tcccccagat 193321 gaccgcgtga atcacgttct tagcgatctg ctgccaaggt gtcgagttga cgaatccgga 193381 cccgaacgcc gccaacccgg tcagcaagac cagcaccacg acgggccaga ttaagcgatt 193441 ccagtgcgga tggcggtgca gaacgacctg ctcgccagcg gccaggacat tctccggata 193501 gctcatgccc gcgaccttaa tcttttgggg acgccagctc cgcgcgagtt aacgcaaatg 193561 caccacgtcg cccgctgaaa caactaccgt tcgaccgccg acgtccagac acagccgacc 193621 ctggtcatcg atgtcacgcg cgatcccgac gacgtcctgg ccaccgggga gctcgacgcg 193681 cacgcgcgac ccaatggtca ggctgcgagc acggtagtcg gccgccagtt gtgggttggc 193741 gttgcgccac tggatgatcc gagcttcgag ctcgcgcaac agcctgctgg ctatgcggtt 193801 gcggtccggt gccgccactc cgaggtccag caatgaggtc gcgtcgggat caacctcttc 193861 gggggcctgg gtgacgttga gtcccacacc gagtaccaca aacggctgcg cgacctcggc 193921 caggatgccg gctaacttgc caccccgggc cagcacgtca ttgggccact tgaggcccgt 193981 ttcggccggc gggactgcaa tcaggggggc caccgaatcg agcaccgcca gacccgcggc 194041 cagtgacagc cagccccacg cttgcaccgg gacgtcgacc acacgcacac cgaccgacag 194101 gatgatctgc gctcgggcag tggccgccca gccgcggcca tgacgccccc gcccagcggt 194161 ctgatgctcg gcgatcaaca ccaccccgtc gatatcggcc ccggatgccg cccgggccag 194221 caagtcggcg ttggtggaac cggtttgggc cacgacgtca agttggcgcc acccggatcc 194281 agcaccgatc agctggtcgc gcagtgagcg ttcgtccaaa ggcggcctga gccgatcgcg 194341 gtcggtcacc gccccagcct aaggaagtag tgtgcggcag ccgataacat cgactcccat 194401 gacaagcgtt accgaccgct cggctcattc cgcagagcgg tccaccgagc acaccatcga 194461 catccacacc accgcgggca agctggcgga gctgcacaaa cgcagggaag agtcgctgca 194521 ccccgtcggt gaggatgccg tcgaaaaagt acacgccaag ggcaagctga cggctcgcga 194581 gcgtatctac gcgttgctgg atgaggattc gttcgtcgag ctggacgcgc tggccaaaca 194641 ccgcagcacc aacttcaatc tcggtgaaaa acgcccgctc ggcgacggcg tggtcaccgg 194701 ctacggcacc atcgacgggc gcgacgtgtg catcttcagc caggacgcca cggtgtttgg 194761 cggcagcctt ggcgaggtgt acggcgagaa aatcgtcaag gtccaggaac tggcgatcaa 194821 gaccggccgt ccgctcatcg gcatcaacga cggtgctggc gcgcgcatcc aggaaggtgt 194881 cgtctcgctg ggcctgtaca gccgtatctt tcgcaacaac atcctggcct ccggcgtcat 194941 cccgcaaatc tcgttgatca tgggagccgc cgccggtggg cacgtctact cccccgccct 195001 gaccgacttc gtgatcatgg tcgatcagac cagccagatg ttcatcaccg ggcccgacgt 195061 catcaagacc gtcaccggcg aggaagtcac catggaagaa ctcggcggcg cccacaccca 195121 catggccaag tcgggtacgg cacactacgc cgcatcgggc gaacaggacg ccttcgacta 195181 cgttcgcgag ctgctgagct acctgccgcc caacaactcc accgacgcgc cccgatacca 195241 agccgcagcc ccgacagggc ccatcgagga gaacctcacc gacgaggacc tcgaattgga 195301 tacgctgatc ccggactcgc ccaaccagcc ctatgacatg cacgaggtga tcacccggct 195361 cctcgacgac gaattcctgg agatacaggc cggttacgcc caaaacatcg tggtggggtt 195421 cgggcgcatc gacggccggc cagtcggcat tgtcgccaac cagccgacac acttcgccgg 195481 ctgcctggat atcaacgcct cggagaaagc ggcccggttt gtgcggacct gcgactgctt 195541 caatatcccc atcgtcatgc tggtggacgt cccgggcttc ctgccgggca ccgaccagga 195601 atacaacggc atcatccggc gcggcgccaa gctgctctac gcctacggcg aggccaccgt 195661 gccaaagatc acggtcatca cccgcaaggc ctacggcggt gcgtactgcg ttatgggctc 195721 caaagacatg ggctgcgacg tcaacctggc gtggccgacc gcgcagatcg cggtgatggg 195781 cgcctccggc gcagtgggct tcgtgtaccg ccagcagctg gccgaggccg ccgccaacgg 195841 cgaggacatc gacaagctgc ggctgcggct ccagcaggag tacgaggaca cactggtcaa 195901 cccgtacgtg gccgccgaac gcggatacgt cgacgcggtg atcccgccgt cgcatactcg 195961 cggctacatc gggaccgcgc tgcggctgct ggaacgcaag atcgcgcagc tgccgcccaa 196021 aaagcatggg aacgtgcccc tgtgagtcga gtgagcggaa cgaacctgtg agtcgagtga 196081 gcggaacgaa cgaagtgagt gacgggaacg agacgaacaa tccggcagaa gtgagtgacg 196141 ggaacgagac gaacaatccg gcagaagtga gtgacgggaa cgagacgaac aatccggccc 196201 ctgtgagtcg agtgagcgga acgaacgaag tgagtgacgg gaacgagacg aacaatccgg 196261 cccctgtgag tcgagtgagc ggaacgaacg aagtgagtga cgggaacgag acgaacaatc 196321 cggcccctgt gaccgagaag ccgctgcatc cgcacgagcc ccacatcgag atactgcggg 196381 gacaacccac cgatcaggag ctggccgcgt tgatcgcggt gctgggcagt atcagcggtt 196441 caaccccgcc cgcgcaaccc gagcccaccc ggtgggggct gccggtcgac cagttgcggt 196501 accccgtctt cagttggcag cgcatcacac tgcaagaaat gacgcacatg cgccgatgac 196561 ccggctggtg ctcgggtccg cctcccctgg ccggctcaaa gtccttcgtg atgccggcat 196621 tgagccgctg gtcatcgcct cgcacgtcga cgaggatgtc gtcatcgcgg cgctggggcc 196681 ggacgcggtc ccgagcgatg tggtgtgcgt actggccgcg gcaaaggccg cgcaggtcgc 196741 gaccacgctg accggaacgc aacgcattgt ggccgcggat tgcgttgtcg ttgcctgtga 196801 ttcgatgctc tacatcgaag gcaggctact cggcaagcca gcgtcaatcg acgaggcgcg 196861 cgagcagtgg cggtcgatgg cgggccgggc cggccaactc tatacgggcc acggtgttat 196921 ccggttgcag gacaacaaaa ccgtgtaccg tgctgctgaa acagcaataa ccacagtata 196981 tttcggaaca ccttcggcct ccgatctgga ggcttacctg gccagtgggg agtcgctgcg 197041 ggtcgcgggt ggattcaccc tggacggtct gggcggctgg ttcatcgacg gcgtgcaggg 197101 caatccgtcg aatgtgatcg gcttgagcct gccgttgctg cggtcgctcg tgcagcgatg 197161 cgggctgtcc gtcgccgcac tgtgggcagg aaatgcgggc ggcccagcgc acaagcagca 197221 gtagcttcgg actgggccag gtcgccagcg gtaggctcga tgatgtgccg cttcccgcag 197281 accctagccc caccttgtcg gcctacgccc atcccgaacg gctcgtgacc gccgactggt 197341 tgtcggcaca catgggcgcg ccgggcctgg cgatcgtcga atccgacgag gacgtcttgc 197401 tctacgacgt cggccatatt cccggcgccg tcaagatcga ctggcacacc gacctcaacg 197461 acccacgggt gcgcgactac atcaacggcg agcagttcgc cgaattgatg gaccgcaagg 197521 gcatcgcccg cgatgacacc gtggtgatct atggcgacaa gagcaattgg tgggccgcct 197581 atgcgttgtg ggtgttcacg ctgttcggtc acgccgacgt gcgactcctc aacggcggcc 197641 gtgacctctg gctcgccgag cgccgggaaa ccaccttgga cgtcccgacc aagacctgca 197701 ccggttatcc cgtcgtgcag cgcaacgatg cacccatccg cgcattcaga gacgacgtgc 197761 tggccatcct gggcgctcag ccgctgatcg acgtacgctc tcccgaggag tacaccggca 197821 agcgcaccca tatgcccgat taccccgagg aaggggcgct gcgggccggt cacatcccca 197881 cggcggtgca cattccgtgg gggaaggccg ccgacgaaag tggacggttt cgcagccgcg 197941 aggaattgga acggctctat gacttcataa acccggacga ccaaaccgtc gtctattgcc 198001 gcatcggtga acgctccagc catacctggt tcgtgctcac acacctgctg ggcaaggcag 198061 atgtacggaa ctacgacggc tcgtggaccg agtggggcaa cgccgtgcga gtgccgatcg 198121 tcgcgggcga agaaccagga gtggtacccg tcgtatgacc gcgcccgcga gcctgcccgc 198181 gccgctagca gaggtggtat ccgacttcgc cgaagtccag ggtcaagaca agctgaggct 198241 gttgctggaa ttcgccaacg agctgccggc gcttccgtcg cacctggccg agtccgctat 198301 ggagccggtc cccgagtgcc agtctccgct gtttttgcac gtcgacgcga gtgaccccaa 198361 ccgggtgcgc ctgcatttca gcgcgccggc cgaagcgcca accacgcgcg ggttcgcctc 198421 gatcctggcc gccggcctag acgagcaacc ggccgccgac atcttggcgg tgcccgagga 198481 tttctacacc gagctgggtc tggctgcctt gatcagccca ctgcggttgc ggggaatgtc 198541 ggcgatgctg gcccggatca agcgccggct gcgcgaagcg gactgaatcg aggaaccgcg 198601 tgagcgggtc agcggcgcga cgcttaaact tcccccgaca agacttgtaa gaaaatctct 198661 tagagacgaa gaatcagccc gacaggaggc gcagtggcta gtcacgccgg ctcgaggatc 198721 gctcggatct ctaaggttct cgtcgccaat cgcggcgaga tcgcagtgcg ggtgatccgg 198781 gcggcccgcg acgccggcct gcccagcgtg gcggtgtacg ccgaacccga cgccgagtcc 198841 ccgcatgttc ggctggccga cgaggcgttc gcgctgggcg gccagacctc ggcggagtcc 198901 tatctggact tcgccaagat cctcgacgcg gcagccaagt ccggggccaa cgccatccac 198961 cccggctacg gcttcctagc ggaaaatgcc gacttcgccc aggcggtgat cgacgccggc 199021 ctgatctgga tcggccccag cccgcagtcg atccgcgacc tgggcgacaa ggtcacggcc 199081 cgtcacatcg cggcccgcgc tcaggcgccc ctggtgccgg gtacccccga tccggtcaaa 199141 ggcgccgacg aggtggtggc attcgccgag gagtacggcc tgccgatcgc gatcaaggcc 199201 gcccacggcg gcggcggcaa gggcatgaag gtggcccgca ccatcgacga gattccggag 199261 ctgtacgagt cggcggtgcg cgaggccacg gccgcgttcg gccgcggtga gtgctacgtg 199321 gagcgctatc tcgacaagcc gcgccacgtc gaagcacagg tgatcgccga ccagcacggc 199381 aacgtcgtcg tcgccggcac ccgggactgc tcgctgcagc gccgctacca gaagctggtc 199441 gaggaggcgc ccgcaccgtt cctgaccgac tttcaacgca aagagatcca cgactcggcc 199501 aaacggattt gcaaagaggc ccattaccac ggcgccggca ccgtcgaata cctggtcggt 199561 caggacggct tgatctcgtt cttggaggtc aacacgcgcc ttcaggtaga acacccggtc 199621 accgaggaaa ccgcgggcat cgacttggtg ctgcagcaat tccggatcgc caacggcgaa 199681 aagctggaca tcaccgagga tcccaccccg cgcgggcacg ccatcgaatt ccggatcaac 199741 ggcgaggacg cggggcgtaa cttcctaccg gcgcccgggc cggtgacaaa gttccacccg 199801 ccgtccggcc ccggtgtgcg ggtggactcc ggtgtcgaga ccggctcggt gatcggcggc 199861 cagttcgact cgatgctggc caagctgatc gtgcacggtg ccgaccgcgc cgaggcgctg 199921 gcgcgggccc ggcgcgcgct gaacgagttc ggtgtcgaag gcctggcgac ggtcatcccg 199981 tttcaccgcg ccgtggtgtc cgacccggca ttcatcggcg acgcgaacgg cttttcggta 200041 catacccgct ggatcgagac cgagtggaat aacaccatcg agccctttac cgacggcgaa 200101 cctctcgacg aggacgcccg gccgcgtcag aaggtggtcg tcgaaatcga cggtcgccgc 200161 gtcgaagtct cgctgccggc tgatctcgcg ctgtccaatg gcggcggttg cgacccggtc 200221 ggtgtcatcc ggcgcaagcc caagccgcgc aagcggggtg cgcacaccgg cgcggcggcc 200281 tccggtgacg cggtgaccgc gcctatgcag ggcaccgtag ttaagttcgc ggtcgaagaa 200341 gggcaagagg tcgtggccgg cgacctagtg gtggtcctcg aggcgatgaa gatggaaaac 200401 ccggtcaccg cgcataagga tggcaccatc accgggctgg cggtcgaggc gggcgcggcc 200461 atcacccagg gcacggtgct cgccgagatc aagtaagccc ggcggctact ccaactgatc 200521 ccgtagccgt gccaatgact tggccagcag ccgcgacacg tgcatctgtg agataccgac 200581 gcgctcggcg atctgcgttt gggtcatcga gtcgaagaac ctgagcacca agaccgttcg 200641 ttcccgctcg ggcaacgcct cgagcaacgg acgaagcacc tcccgattct cgatctggtc 200701 aagacccgca tccacgtcgc ccagggtgtc tgtgattgcg cgggcatcgt cgtcgctgcc 200761 gccaccgctg tcgatggaca aggtgtggta ggaactaccc gccagcaaac cttcgataac 200821 ctcagcgcgg tccatcccga gctccgcggc gagctccgat gccgacggcg cccgcccgag 200881 ccgctgcgac aaatcggcgg tggcggtacc tagccgcaga tgcagttcct tgagacgccg 200941 gggaaccttg accgaccagc tgttgtcgcg gaagtgtcgt cggacctcgc ccatgatggt 201001 aggaaccgcg aaggagacga agtccgaccc ggtcttcacg tcgaagcgaa ccgcggcgtt 201061 gaccagcccg acccgcgcga cctgaataag gtcgtcacgc ggttcgccgc gaccctcgaa 201121 ccgccgcgcg atgtgatcgg ccagcggcaa gcaccgctga acgatcttgt cccggtgccg 201181 ctggaattcc ggtgagccgg caggcaaacc aaccagctcg cgaaacatct ccggaacgtc 201241 ggcgtattcg ttagctcgcg atgcagaacc gccggcagcg cgcgccgtca cctgctggat 201301 gccgcccgtc gggcggtcaa cgtgatgccg aagacactgc cggctacatc gggctggcga 201361 ccgtcgtgga aggtctggac gtcgtcggcc agcgcggtca ggacatgcca gctaaagctg 201421 cccggtgcca ccacgtcgtg ggtgtcgcag gcagcagaag cctccaccac aacttcgtct 201481 tttcgcggat cgaccaccag gcgcagggtg gcatccggca aggccgagcg aatcaaccgg 201541 gtgcacacct cgtccaccgc caacctcagg tcggccacgg cgtcgaaatc caggtcctcg 201601 aaggtgccga tggcgccgac cagggtgcgc agcagcgcca ggttctccag gcgggcagca 201661 acgttcagct cgacggcgcg gacaccgcgt tggcgcccct tggtgggtaa atccgagtcg 201721 gccatgcacc ctcccggcaa gcttcgatcg acagtactcc cgccttgggt ctggtcttcg 201781 agctggtcgg tcatggtcgg acctgctggt agtggggatc taacgcaaca tggtcgggat 201841 tcatcatggt gtacccgtga tacccattcg cagctgccgg tgaaaccccg cgatgccggg 201901 atttccagcc gcactaggat gtctagccgg ccagccgctg ccgccggact tcgggatgtt 201961 cggtatacca gcgatcggca atcttgcgta tccgccgatg ctcgaacgct agccacgcca 202021 aaccaaccac tgtgacgaca atcgccacca caccaaaggt catgccctcg gcgtgatgtc 202081 cggtgccgaa agccgcaaga gctccgacgc cgccgacgac accggccaca atcaacagat 202141 acccaggcca atgcaccacg tcgatcagcg actcgccggc aagcggccgc gtcgtccgca 202201 agtggtcgac ggggtcacga taggtgtcgc ccatggcctc ctccgtttcc gtcctattcc 202261 gccatttctg cccattacca ggcactacca tcaacggtag aactcgtcga acgggttgtg 202321 gagggatctg acccatttat ttgttgaccg cggccgacct ggccgacggc tcacggcgcc 202381 atgaccgggc cggcgatcgg tgggacgcct atgcagagcg tcagcaccat cagcgtcaac 202441 aaaaaccagc cggcgccgtg ccatccccac caggtacctt ccgcacgcca tacccggtag 202501 gtgcgcagaa acgcccacag cccggccgca cacaggatca gcgggccccc cagcgccagc 202561 aggatccgct ggggcgggcc gcaggccgcg gtgtcgacgc cgctgcacgt gctgaccaac 202621 aacgctccca taatgaggaa accgaccccg acgacagcgg ccacaacagc aaaccgaatc 202681 gccgagtgca cctcgctgtc atcccggcct agccgatcgc cgcgtgacgg cccacctact 202741 tcgtgcatcg gcgaatctcc atcccgctct tggcggctgc cttacgtcac caccggtaac 202801 gcgctgcgca ccgcggctat cgcggcgtcg atctcggcgg ttgaaaccgt cagcggtgga 202861 cggaatcgca cggtgtctgc accggccggc aacacaatca ccgcacgttg ccacagctgg 202921 cggatcaact cgtcacggtc ggcggtggtc ggcaggctaa acgcacacat cagcccgcgg 202981 ccgcgcggat cgagaaccac tgccgggaag tccgcggcga gttcgtcaag ccgggcgcgc 203041 agatacttac cgtgctgcac cgcccgctcg aacaggccct cggcttcgat gacctccaag 203101 atgcggcggg cgcgcaccat gtcggtaaga ttgccacccc atgtcgagtt gagccgtgat 203161 gggaccgcga acacattgtc ggcgacctcg tccacccgcc gaccggccat cactccgcat 203221 acctgcgtct tcttgccgaa cgccacgatg tcgggtgcga catccaactg ctggtatgcc 203281 caggcggttc cggtcaaccc gcagccggtc tgtacttcgt cgaagatcag cagtgcatca 203341 aactcgtcgc acagctcgcg catcgcagcg aaaaactccg ggcggaaatg gcggtcgcca 203401 ccctcgccct ggatgggttc ggccacaaaa cacgcgatgt cgtgcgggcg ggtctcgaat 203461 gccgcgcggg cctggcgtag cgcctcggcc tctagcgcgg ccatagcggg ctcatccagg 203521 ccgggccgca tgtacggcgc atcgatgcgt ggccagtcga atttcgggaa ccgggcggta 203581 atggtcggct tggtgttggt cagcgacagg gtatagccgc tgcggccgtg aaatgccccg 203641 cgcaggtgga gcacttgagt gcccagcgcc gggtcgatcc catgggcttg gttgtgccga 203701 ctcttccagt cgaacgcggc tttgagcgcg ttctccaccg ccagggcgcc cccttcgacg 203761 aagaacagat gcggcagcgc cgggtcgccc aagacacggg cgaaggtctc gacgaagcgg 203821 gccatcgcca ccgagtacac gtcggaattg ctgggcttgt tcagcgcggc ctgcatgagt 203881 tcggcatgga actcccggtc gtccaccagc gccgggggat tcatacccag tgccgaggag 203941 gcaacgaatg tgaacatgtc caggtagcgc cgacccgtta tagcgtcgac cagatatgaa 204001 ccgcccgaac gggtcagatc gagcactatg tccagaccgt cgaccagcat gctgcgccct 204061 agcacctcat gaacccggtc tggtgttgtt ggtctaccgg caagagcgac ggacttcacg 204121 acggcggcca tgacgctatg atagcaggat ttacggaata ttgatattta tgctggaaaa 204181 attatggtat atgctgccta tcgctgtaaa aagtgttcag aatgatcgtg cttcgcgtcc 204241 gcacgttcgc cgttgtccgg atccgttgca acaggtcctc gagcgcccgt gcggacgcga 204301 cgcgcaccag caagacgtag ctctcttcgc cggccaccga gtaacaggac tcgacctcct 204361 cgatatgttc taggcgcgcg ggggcatcat ctggttgaga cggatcaaga ggagtgatag 204421 ccacgaacgc cgacaacaaa tgcccaaccg cctcgggatt gattcgcgcc gaatatccct 204481 ggaccacacc acgagactcc agccggcgca ctcgcgattg gaccgccgag accgacagcc 204541 cggctcgcgt ggccaactct gacagcgtcg cacgtccgtc ggcggccagt tcgcgcacca 204601 ggatccgatc gatatcgtcg agcgcctcgt tcatggccgg agactatcgc aacggcagtg 204661 ccgcatgagc cgctcgaaaa gactgcagac tggccagctg cgcgcgcgct tcgccgccgg 204721 gttgtcagcc atgtacgccg ctgaggtgcc cgcctacggc acgctggtcg aggtatgcgc 204781 acaagtcaac tccgattacc tgacccggca tcggcgagcc gagcggctgg ggtcgcttca 204841 gcgcgtcacc gccgagcgcc acggcgccat ccgagtgggc aacccggccg aactcgctgc 204901 ggtcgccgac ctgttcgccg cgttcgggat gctgccggtc ggctactacg atctgcgcac 204961 cgctgagtca ccaattccag tggtgtccac cgcatttcgc ccaatcgatg cgaacgagct 205021 ggcacacaac ccgtttcggg tgttcacctc gatgctggcc atcgaggatc ggcggtactt 205081 cgatgccgac ctacgcaccc gagtgcagac cttcctcgcg cgccggcaac tctttgaccc 205141 cgcgttgctc gcccaggcgc gggcaatcgc ggctgacggc ggctgcgatg ccgacgacgc 205201 accggctttc gtcgccgcgg cggtggccgc gtttgcgctg tcgcgggaac cggtcgagaa 205261 atcctggtac gacgagttgt ccagggtgtc ggcggtggcc gctgatatcg ctggagtcgg 205321 ctccacacac atcaaccatc tgacgcctcg ggtgctcgac atagacgatc tgtaccgtcg 205381 gatgaccgag cgcggcatca ccatgatcga caccatccaa ggccctcccc gcaccgacgg 205441 acccgatgtg ttgttgcggc aaacctcatt tcgcgcgctg gccgaaccac gcatgtttcg 205501 cgacgaggac ggtaccgtga cgccgggaat cctgcgggtg cggttcggtg aggtcgaggc 205561 gcgcggtgtc gcgctgaccc cgcgagggcg cgaacgctac gaagccgcga tggcggccgc 205621 agatccggcc gcggtctggg ccactcactt tccctcgacg gatgcggaga tggccgctca 205681 aggcttggcc tactaccgag gtggtgaccc gtcagcgccg atcgtctacg aagacttcct 205741 gcccgcttcg gccgcgggca tcttccgctc caacctggat cgcgactcgc aaaccggtga 205801 cggacccgac gatgccggct acaacgtcga ttggttggcc ggggcaatcg gccgacacat 205861 tcacgacccg tatgcgctct atgacgcgct cgcccaggag gagcggcgct gataaccact 205921 gacgcgttac gagcccaggt gctcgaagcc tgccaagcga tcggcgtaac cgccgccctt 205981 ggcgagccgg gcgaacacag cctgcccgcg agcacaccga tcaccggcga cgtgctgttc 206041 agcatcgcac cgaccacccc ggagcaggcc gaccacgcga tcgccgcggc ggccgcaaca 206101 tttacggcat ggcgaagcac gccggccccg gtgcgcggcg cgctcgtggc ccggctcggc 206161 gagctgctca ccgcacacca gcaggacctc gcgacactgg tcacagtcga agtaggcaag 206221 atcaccgccg aggcgcgcgg cgaagtgcag gaaatgatcg acgtctgcca gttctcggtg 206281 ggtctgtcac gccagctcta cggccgcacc atcgcgtcag agcgcgctgg gcaccggctc 206341 ctggaaacct ggcatccgct gggagtggtg ggcgtgatca ccgcgttcaa cttcccggtc 206401 gcggtctggg cgtggaacac cgcggtggca ctggtctgcg gcgacacggt ggtgtggaaa 206461 ccctcggagc tgacgccgtt gacggcgctg gcctgccagg cgctgctcag tcgggccgcc 206521 gctgatgtcg gcgcgccggc cgcggtgggc ggcctgctgt tgggcggcgc cgagcgtggt 206581 gcgcaactcg tcgacgaccc gcgggttgcg ttgttgtcgg cgacgggttc ggtgcggatg 206641 ggccagcagg tcggtccacg cgtcgcccgg cgcttcgggc gggtgctgct ggagttgggc 206701 ggcaacaacg cggccattgt ggcgccgtcg gccgacctgg agctggcggt gcgcggcatc 206761 gtgttcgccg cggccggcac cgcaggtcag cgctgcacca gcctgcgccg gctgatcgtg 206821 caccgctcgg tggctgacga tgtggtggca cgcgtcgtcg gcgcctatcg ccagctggcg 206881 atcggtgacc cgtcggcccc ggacacgctg gtaggcccac tcatccacga ggccgcctac 206941 cgcgacatgg tggcagcgct cgagcgggca cgcaccgacg gcggcgaggt catcggcggt 207001 gatcgtcgcg aggtgggctc accgggcgcc tactatgtcg cgcccgctgt ggtccgaatg 207061 ccgtcccaga ccgccatcgt ggcgaccgaa acgttcgcac caatcctgta cgtgctcacc 207121 tacgacgacc tcgacgaggc gatagccctc aacaacgcgg taccacaagg gctttcgtcg 207181 tcgatcttca cgaccgacct gcgtgaggcc gagcacttcc tcgaccagtc cgactgcggt 207241 atcgccaacg tcaacatcgg gacgtcggga gcggagatcg gtggtgcctt cggcggcgag 207301 aagcagaccg gcggcggccg cgagtccggg tccgacgcgt ggaaggccta catgcgccgg 207361 gccaccaaca ccgtcaacta ctcgagcgag ctgccgctgg cgcagggcgt gaagttcggg 207421 taaccatgcc cgtgggtgcg tctgggcatc atcgacgcgc gcttggggtt gggcggggtg 207481 gaattcatcc atttcattca gtgcccgttg cgaatcccca agctaccccg acggcgacca 207541 gaggatgtcg atggggacgg cggcgaggcg gtcgccgaat ggctgggctt gtgggccggt 207601 gtgcaggatc acgccgccgg cgaagcgtgc gccgactttg tcgcggagtc tgctgatcga 207661 gcgggtgtct ctaccacgga gggttgccgc cgacttgatt tcgatcgcgg caatgaggcc 207721 gtctgcggtt tccagtatga ggtctacttc ggcgccgtct cgatcgcggt agtggaacag 207781 tcgaggtgcc tgttgcgacc atccgagttg tcgccggagt tctgcgatca cgaaagtttc 207841 gatgatggct ccggccgcgt tggggttggc atgtggaccg gctccggtag gcgagacatt 207901 gacgaggcga gcggccagtc cggagtcgag aaggaggact ttcggtctat cgacgacccg 207961 cttggaaagg ttggtcgacc acgcgggtat gcggtcgatg agatacaggg tctcgaggag 208021 gtcgaggtac ggcggcaggg tacgtacggg gatttcggcg tcggtagcta gggagctcag 208081 gttaagttcg gacgcgctgc gtgcggctag aagtcggatg aggcgcggca ggtcggcgat 208141 gcgttggaga ttggagacgt cggccgcgtc acgtttgacg acgcggtcga cgttcctagc 208201 tttcgccgat tcgcgacaaa gccgtcgccg atacgcggca ctatcttcgc caattcgcgg 208261 atatctcctc accgattcgc gatatctggc ggagccggtg gtgtcgcagc agggacgtcg 208321 gggcagaccc accccaccga aagaaccacc accacctgct cgcctagccg aacgtgtggt 208381 ctacgtgagt aatatctgtc acatggcgac agccagaagg cggttatccc cgcaggaccg 208441 ccgcgctgaa ctgctcgctc tgggggcgga ggtctttggg aagcggcctt acgacgaggt 208501 tcgcatcgat gagatcgccg agcgcgctgg ggtgtcgcgg gcactgatgt atcactactt 208561 cccggacaag cgggcgttct tcgccgcggt cgtcaaggac gaggccgacc ggctgtacgc 208621 ggcgaccaac aaggcgcccg cccctgggat gacgatgttc gaagagatac gaaccggcgt 208681 gctggcctat atggcctacc accaacaaaa ccccgaggcg gcgtgggccg cctacgtcgg 208741 cctcggccga tcggacccgg ttctgctcgg tatcgacgac gaagccaaga accgccagat 208801 ggaacacatc atgtcccgca tcgccgaggt cgtgagcggg attgaccgcg ataacaccct 208861 ggacccagag gtcgagcgcg acctgcgggt gatcatccac ggctggctgg cgttcacctt 208921 cgagctgtgt cgtcagcgga tcatggaccc gtcgaccgac gctgaacggc tcgccgatgc 208981 ttgcgcacac gcgctgctgg acgccatctc ccggctgccg cagatccctg ccgaactggc 209041 tgacgcgatg gcaaccgcgc gaatgtgagc ggtaggcggt ttttgtcggt gcctgttggc 209101 acgatggcta ggtgaggttc gcgcagcctt cagcactgag ccgattcagc gcgctcaccc 209161 gagactggtt caccagcact ttcgccgcgc ccaccgccgc ccaggccagc gcctgggcgg 209221 ccatcgcaga cggcgacaac acgctggtca tcgctcccac cggatccggg aagaccctgg 209281 cggcgttcct gtgggccctg gatagcttgg ccggttcgga acctatgtcc gagcggccgg 209341 cggccacccg cgtgctgtat gtgtcgccgc tcaaagcgtt ggccgtcgac gtcgagcgca 209401 acctgcgcac tccgctggcc ggactgaccc gactcgccga acgccagggt ctgcccgcgc 209461 cccagatcag ggtgggcgtc cgttcgggcg acaccccgcc cgcacttcgc cgccagctcg 209521 tcagccagcc gcccgacgtg ctgatcacca ccccggagtc attgtttttg atgctcactt 209581 cggccgcacg ccaaactctg accggtgtgc agaccgtcat catcgacgaa attcatgcca 209641 tcgccgccac caagcgcggc gcacacctgg cactatccct agaacggctc gacgacctgt 209701 ctagccggcg acgggcgcag cgcatcgggc tgtcggcgac cgtacgtcct cccgaggaac 209761 tcgcaaggtt cctgtccgga cagtccccga cgaccattgt ggcgcccccg gccgccaaga 209821 ccgttgagct gtccgtgcag gtgccggtgc ccgacatggc caacttgacc gacaacacca 209881 tctggccgga tgtggaggct cggctggtcg acctgatcga atcacacaac tcgaccatcg 209941 tgttcgccaa ttcgcgacga ttggccgagc gacttaccgc acggctcaac gaaattcacg 210001 ccgcgcgctg cgggattgag ctcgcgccag acaccaacca gcaggttgcc ggcggcgccc 210061 cggcgcacat catgggctcg ggccagacgt tcggagcgcc gccggtgctg gcccgcgccc 210121 accatggctc gatcagcaag gagcagcgcg ccgttgtcga agaggacctc aaacgcgggc 210181 aactcaaagc ggtggtggcg acgtccagcc tggagctggg catcgacatg ggcgcggtcg 210241 atctggtgat ccaagtacag gcaccaccat cggtggccag cgggctgcag cgcattggcc 210301 gggccggtca tcaggtcggc gagatttcgc ggggggtgct gtttcccaag catcgcaccg 210361 acctactcgg ctgcgcggtc agcgtgcagc gcatgcttgc cggtgagatc gagaccatgc 210421 gggtgccggc caacccactc gacattctgg cccagcacac ggtggcggcg gctgcgctgg 210481 aaccgttgga tgccgacgcg tggttcgaca ccgtgcggcg ggccgccccg ttcgcgaccc 210541 tgccgcgtag cctgttcgag gccaccctgg acctgctgtc cggcaagtac ccatccaccg 210601 agttcgctga gctgcggccg cggctggtgt atgaccgcga taccggcacg ctgaccgcgc 210661 gacccggagc ccagcgactg gccgtcacct ccggcggcgc cattcccgat cgcgggttgt 210721 tcgccgtcta cctcgctacc gagcggccgt cgcgggtagg cgaactcgac gaggaaatgg 210781 tttacgagtc ccgccccggt gacgtgatct cgctgggtgc caccagctgg cgaatcaccg 210841 agatcaccca cgaccgggtg ctggtgatcc ccgcgccggg ccagccggcc cgattgccgt 210901 tctggcgcgg agacgatgcc ggccgccccg ccgagctcgg cgccgcactc ggcgccctca 210961 ccggcgagct ggccgccctg gaccgtacgg cattcggcac acgttgtgcg ggtttgggtt 211021 tcgacgacta tgccaccgac aacctgtggc gactgctgga cgaccaacgc accgctaccg 211081 cagtggtacc caccgacagc acattgttgg tcgagcggtt tcgtgacgag ctgggcgatt 211141 ggcgggtgat cttgcattcg ccgtatgggc tgcgggtgca cggaccgctc gcgctcgcag 211201 tcggccggcg gctgcgcgac cgctatggca tcgacgagaa gccgaccgcc tccgacaacg 211261 gcatagtggt gcgcctaccg gacaccgtgt ccgctggcga agacagcccg ccgggtgccg 211321 aactgttcgt tttcgacgcc gacgagatcg acccgatcgt caccaccgaa gtggccggtt 211381 cggcgctgtt cgcgtcacgg ttccgggaat cggcggcccg cgctctgctg ctgccccgcc 211441 ggcaccccgg ccgccgctcg ccgctgtggc agcagcggca gcgcgccgcc cggctgttgg 211501 aagtggcccg caaatacccc gacttcccga ttgtgctgga gacggtccgc gagtgcctgc 211561 aggacgtcta tgacgtcccg atcttggtcg agctgatggc gcggatcgcc cagcggcggg 211621 tgcgtgtcgc cgaagccgag accgccaaac cttcgccatt tgcggcatcg ctgttgttcg 211681 gctacgtcgg cgccttcatg tacgagggcg atacgccgct ggccgaacgg cgcgccgccg 211741 cgctcgcgct ggacggcacg ttgctggccg agctgctagg ccgggtggag ctgcgcgagc 211801 tgctcgatcc tgacgtcatc gccgctacca gccgccagct ccagcatctg gcggccgacc 211861 gggtagcccg tgacgccgaa ggggttgccg atctgctgcg gctgctgggt ccgctcaccg 211921 aagacgagat cgctgcccgg gcgggcgcgc ccgaggtcag cggctggctg gacggcttac 211981 gcgccgccaa acgcgcgctc gtggtgtcct tcgccggccg cagctggtgg gttgccgtcg 212041 aggacatggg ccggctgcgc gacggcgttg gcgcggcggt tccggtgggg ctgccggcca 212101 gcttcaccga ggcggtagcc gacccgctgg gcgaactact gggccgctac gcacgcaccc 212161 acacaccgtt caccaccgct gcggccgcag cccggttcgg tcttgggctg cgggtgaccg 212221 ccgacgtgct gggccggctg gccagcgatg gccggctggt gcgcggcgaa ttcgtggccg 212281 cggccaaagg atccgccggc ggcgagcagt ggtgtgacgc cgaggtgttg cgaattctgc 212341 ggcgccgctc gctggccgca ctgagggcgc aggcagagcc ggtcagcacc gccgcctacg 212401 gacgcttcct gccggcctgg cagcacgttt ccgcgggcaa ctcgggcatc gacgggctgg 212461 ccgcggtcat cgatcagctc gccggcgtcc ggataccggc ctcggcgatc gaaccgctgg 212521 tgcttgcccc acggatccgc gattactcgc cggcgatgct cgacgagctg ctcgcgagcg 212581 gggacgtcac ctggtcgggc gccgggtcga tctcaggcag tgacggctgg atcgccctgc 212641 accccgccga ctcggcgccc atgacgctgg cggagccggc cgagatcgac ttcaccgacg 212701 cccaccgggc gatcttagcc agcctgggca ctggcggcgc gtacttcttc cgccagttga 212761 cccacgacgg cctgaccgag gcggaactca aagccgctct gtgggaattg atttgggccg 212821 gacgagtgac cggcgacacg ttcgcaccgg tacgcgcggt actcggcggg gcgggcaccc 212881 ggaagcgtgc tgctcccgca cacggcgggc atcgaccgcc gcgcctgagc cgataccgcc 212941 tcacgcacgc ccaggcccgc aacgctgacc cgaccgtcgc cgggcggtgg tccgcgctgc 213001 cgcttcccga accggactcc acgctgcgcg cccattacca agccgagctg ctgttgaacc 213061 gccacggcgt gttgaccaaa gacgcagttg ctgccgaggg tgtggcgggc gggttcgcga 213121 cgctctacaa ggtgctcagt gcgttcgagg atgccggcag gtgccagcgt ggctacttca 213181 tcgagtcgtt ggggggcgct cagttcgccg tcgcctcgac cgtagaccgg ctgcgtagct 213241 acctcgacgg tgtcgacccc gaacagccgg actaccacgc ggtggtgctg gccgctgccg 213301 acccggccaa cccgtatggg gcggcgttgc cctggccagc gtcgagcgct gacggtaccg 213361 cccggccggg ccgcaaagcc ggcgcactgg tcgttctggt ggacggcgag ttggcctggt 213421 tcctcgagcg cggcgggcgg tcgttgctga cgttcaccga tgatcccgag gccaaccacg 213481 cggcggccat cgggctggcc gacctggtca ccgccgggcg cgtcgcgtcg attctggtcg 213541 agcgggccga cggcatgccg gtgctgcagc ccggcgggcg ggcgtcggcg gcactgacgg 213601 cgctgctggc agccggcttc gtccgcacac ctcgcggtct gcggcggcgg taagccatgc 213661 ccgagggcga caccgtctgg cacaccgcgg ccacgttgcg gcggcatctg gccggtcgca 213721 cgttgacacg ttgcgacatc cgagtgccac ggtttgccgc cgtcgacctc accggcgagg 213781 tagtggacga ggtgatcagt cggggcaagc acctgttcat ccgaaccggg acagccagca 213841 ttcattcgca tctgcagatg gacggcagct ggcgggtcgg caacaggccg gtgcgggtgg 213901 atcatcgggc gcgaatcatt ttggaagcca accagcaaga acaggccatc cgggtggtcg 213961 gcgtcgacct aggcctgttg gaggtcatcg accggcacaa cgacggcgcc gtcgtcgcac 214021 acctaggacc tgatctgctg gccgacgatt gggacccgca gcgtgcagcc gccaacctga 214081 tcgttgcccc ggaccggccc atcgccgagg cactgctcga ccagcgggtg ctcgccggga 214141 tcggcaacgt gtattgcaac gaactgtgct tcgtcagcgg agtattgccg acggccccgg 214201 tgagcgcggt cgccgacccg cgccgcctgg tcacccgcgc ccgagacatg ctgtgggtca 214261 accgcttccg ctggaatcgg tgcaccactg gcgatacccg ggccggccgg cgactgtggg 214321 tctacgggcg ggccgggcag ggttgccgcc gctgcggcac gctcatcgcc tacgacacta 214381 ccgacgagcg ggtgcggtat tggtgcccgg cctgccagcg ctgaaccggg cgatcaaagc 214441 cagcacctag tcgcggccgt gggtagcgaa gaactgggca atgacttgcg acccgtcgaa 214501 cgcgcgcgtg gtcgccccga tgaccgcctt gggcagatat tgcctgccac ccggccaggt 214561 atgtccgcca ttgtcgatct ggtaggagat cacctcggtg ccggccgcac atgagctgga 214621 atcgaaaagg tgcaccattg ttccgtcccc gacgtcaggc agctccgccg ccgacggatc 214681 gccctgacac ccatcgaccg cccgccagcg atccaccaag ctcgcaaccg agatggaatg 214741 gctgagcccg ccgcgaccac gcaccgcccc gccgttgaac ggcaccagcg ggtcggcggt 214801 gccgtgtgct tcgagcaccg acaccggccg cgacggatta catgtcacac ccacacccag 214861 cgtgcccgcc accggcgcga ccgcggcgaa gatatcggca cggtcacacg ccagccggtt 214921 ggacatgaag ccaccgttgg acatgccggt ggcgaagacg tgcccgggag cgatgtcgaa 214981 gtcgtgcacc agctttgcgg ccagcgcgac caagaaccca acgtcgtcga gatgacggcg 215041 atccgccggc gacgcccccc tcccgtcggc ccagcttttg tcgtagccgt caggatagac 215101 aaccaacaag tcggcggcgt cggcaacagc gtcgaaatcg gtgagagcct cctgtccggc 215161 tccggtgccg ccaccaccgt gcaggctgat caccaacccg gagggctcag cgggcggcac 215221 gtgcaagcga taactgcggg tcaagccccc gaactggaac gtcgctaccg aactggcatg 215281 cctggccagt agctgatcac cgccacaccc ggccaggcaa accatgagaa cgataagcga 215341 cagcattcgc gcccacggca tctcgtcaag gtaccgatcg cgagcgctca gcccgcggcg 215401 ccctgtccca ccgcttggac cgatgcgtgc tcgtgcaacg ccctggcggc ttcgggatgt 215461 acgggcttga ggtcgaagat gacctcggtg acggtcccgg tgaacgcata gggcgccttg 215521 tcctcatagc cgcggtcaac gaccaggccg ttgtcgcggc cgatgtccat gccggcatag 215581 gaggtaaagg ccagcggcac cgtctggggc agctcaccct ctccgatcaa ccgatcgtcg 215641 gcccagagcg tcacccgacc accggaggcg gcgacgggtt gatgggaatc gaacagcatc 215701 cgcaccgtga catccccggt ggggagcggc tcgctggaca cctgccggta ggtttcgacg 215761 cccaggaagg agtaggtgtg gtgcaggtgc cgctgttcgt cgacccatag cgcgaaccct 215821 cccatgaagt cggcgttggc gacgatcaca ccctgcgcgc cgccgtcggg gatgtgcagc 215881 cgtgcctcga tcgcgtaaga acgaccgcag atacggggga ccatgccgcg ctgaatgttc 215941 tgcacgtcac ctttgaaact gaaccgtgcg gtggtgggca ggggcggcag gtcgccgaac 216001 attaccgcga gcccgcccag cagcggcagc acccggtttc gttcggcctc ctgccaccac 216061 agctgggtga gctcggcgac cttgtcggga tgctcggctg ccaggttttt cgcctgggag 216121 aagtcatctg gtaggtagta cagctcccag acgtcctggt ccgggtcgta ggtccccggc 216181 gcgaaccgtc gcatcgtctc cggtgacaga tcccagggcg ccttgtccaa gcgagcgcac 216241 gcccaccagc cgtctttgta gatggcacgg ctgccgaagt tttcgaagta ctgcacggtg 216301 tggcggtctt cggcttcagc gtcgtcgaag gtccgcacga aactggttcc gtccatcggt 216361 tcctgctcga agccgtcgac atgggtcggc tccggtaaac cgatggccgc caacacggtc 216421 ggcgcgatgt cgatgcagtg ggtgaactgg ctacgaacac ggccgtctgg ccggatccgg 216481 gccggccaag cgaccaccaa tggatcgcgc gtgccgccca ggtggctggc catctgcttg 216541 ccccactgca acggggtgtt gctcgcatgc gcccacgcgc tggcgaaatg cggtgcggtg 216601 aactcgtcgc cgagtgcggc gatgccgccg tattgttcga tcagctccaa ttgccgctcg 216661 gcatccagat ccaggccgtt aaggaacgtc atctcattga acgaaccggt gttggtgccc 216721 tccatgctgg cgccattgtc gccccagatg tagaacacca acgtgttgtc ggactcgccg 216781 agatcctcga tcgcgtccag cagccggcca acattccagt ccgcattttc cgagaacccg 216841 gcgaacacct ccatctggcg ggcaaagagc cgtttttgcg cctccgacat actgtcccac 216901 gcggggaata ggtcgggccg ctcggtgagt tcggcgtcgg gtggaatgat cccgagtcgc 216961 ttttgccgtt cgaatgtctt ctgccggtac acatcccagc catcatcgaa ctcacctcgg 217021 tacttgtcgg cccattcctt gaatacgtgg tgtggcgcgt gggtggcgcc ggtcgcgtag 217081 tacagcatcc acggcttggt ggcattctgg gcccgcacgg tgtgcagcca ctcgatagcc 217141 ttgtcggtga ggtcgtcggg gaaatagtag ggacggccgt cttccccaga accctcgggt 217201 atgcctatga cggagttgtc ctgactgatg atcgggtcgt actgacccgc ggcgccgctc 217261 gggaagcccc agaaatggtc gaatccccaa cccagcggcc agttgtcgaa cggccccgcg 217321 gctccctgga cattgtccgg ggtcagatgc cacttgccga aagcgccagt cacataaccg 217381 ttgtcgcgca gaatacgcgg cagcgctgcg caactgcgtg gcctgaccgc cgaatacccc 217441 gggtacgggc cggggaactc gcagaccgac ccgaagccca cccggtgatg gttacgcccg 217501 gtcaacagcg ccgcacgggt cggcgagcac accgcggtca catgaaaacg gttgtagatc 217561 aacccattct gggctagccg ggacagcgtc ggggttcgga tcgcgccgcc gaatgtatcc 217621 ggtccgccga acccagcgtc atcgatcaac acgatcagca cattcggtgc gtcgtcgggc 217681 ggaaagggac cggggacaat cgaccagtcg ccgaccgact ctgccatggt gcggccaacc 217741 acgccaccaa agcggcgctg cggtagcggc agccgggtgc ggtctgggtt gaacttgccc 217801 atcgcctctc gcaacgccgc acccaggctt cgcaacgtcg aacgactcag ctccgcaacc 217861 gatttcattg gagagctagc caacgcctgc cccgcttcca gtcggccttg tgcctccgtc 217921 acggcgatga ccactgctcg gcccgccgcc agcgcttggc cgatcttgtc ggccagcccg 217981 gtcttgatcc gatggtgggc gaaggtgccg gccaatgctc cggtcgcggc gccgagcgcc 218041 gccgaggcca acagtgccgg cgagaacagg ccgatcgcca ggcccacccc ggcgccccac 218101 gcggcgccgc gccggccgag ccgatttccg gtgtcgacca aaaccggact gccctcggcg 218161 tccttgccga tcagcaccgc accctgcagc ggaatgcttt tgtccttggc ggcatcgacg 218221 agggtttgaa aatcgtgacg agccgaatcg aggtcctgat agccggcgac gagcaccagc 218281 gcgttgtctt cactcatcac gaaactcccg atatgtgtgt cacggccggc aatcggccgc 218341 ggctgaccat gttggcaacg tagcaccggt caacgtgcgc gtgctggcga actcgcggtg 218401 cgacccggtc agcggatcgt cgaactcgat gcgctgcgcg agcaactgca gcggtgtgct 218461 gaagtcgtgg gcggccacgg atatcacgtt ggggtacaac gggtcaccca tgatcggtat 218521 ccccagcgcc gccatgtgca ctcgcagctg gtgggtgcgc ccggtggtcg gtgtcagccg 218581 atacagaccg tcgcgcgcta tccgctccac cagcgtctcc gcgttgggaa cgccgggctc 218641 acagaccgcc tgcagatggc cccggcgctt gacgatgcga ctgcggacca ggcgcggcag 218701 ggccagaccc ggggcaacgg gtgcgcgagc cagataggtc ttgcgcacca aaccgcgggc 218761 gaacatcgtc tggtagctgc cgcgcacctc gcgtcgggtg gtgaacaaca acaccccggc 218821 ggtcagccgg tccagccggt gggccgggct cagctcgggc aatcccagtt cgcgacgcag 218881 ccgcaccagc gcggtctgcg cgacgtgtcg cccccgaggc atggtcgcca agaaatgtgg 218941 cttgtcgacg acgacgatgt cggcgtcttg atgcagcact gggacatcga agggcaccgg 219001 cacctcgtcg ggcaggtcgc gatacaggtg cacaaccgaa ccgggcggca gcaccgtgcc 219061 actgtcgacc accgcaccgt cgtcgtcgac cacctccccg gccagcacct tcgcacgggc 219121 cgccacgcca aaccgtgcgg tcagctcggc taacaccgac ccgccaagca gtcgcacccg 219181 caccggcccc agcacgtcgt gcacgctaag caaacgatcc tctggccgca acgccacacg 219241 agaccctctc agtaagtgga aatctcgtcc tcggtcggta gcaccccggt gaccatgaag 219301 atgacgcggc ggcccacttc cacagcgtgg tcggcgaagc gctcaaagaa acgacccagc 219361 aacgccgttt ccacaccgac gcgaacgccg tgccgccatt ctcgatctat cagcacgctc 219421 agcaaatgcc tatgcaggtc atccatcgcg tcgtcacgat cgtgcagttg cgcggcttcc 219481 tgcgggtcac ggttcaccag cacttgtctt gcactgtcac ccaacgcgat tgccaccttc 219541 gccatgtcgg cgaagcagtt gcgaacttcc tcaggaagca cctggttcgg atactcgcgt 219601 cgggtgatct tggcaatatg cacagccaac gcacccatgc gctcggtgtc ggcgatgatc 219661 tgcaccgcac tgaagatttc ccgcagctcg ccggccaccg gatgttgcaa cgccagcagc 219721 gcgaacgctt ccttttcgac ttgggctcgc atcgccacga tccgctcatg gtcacggatt 219781 acttgttcag cggcgccaat gtcggcctcg agcagagcct gcgttgcgcg tttcatcgct 219841 atcccggcca ggctgcacat ctctcccaat cgtccggcca actcggttag ccgctggtga 219901 tagaccgtcc gcatggtgtc acgcctctct gaccctgagt cgtcgtgtgg tgctgccgcg 219961 gatccacacc gccatcatcg accatggcgg caccgcgcga catacccgct tggcgtagcc 220021 ttcaatccaa aggcaccggc tcgaggatct cggcacgcgc ctcgggtgcg ctggcccgca 220081 acatgtccgc cgaaacgtcg tcgggctggg cctgggagag cacctcggcc tccacgcgcg 220141 ccatatagtt cgcgacctcg cggtcgatgt ctgcggcggt ccacccgagc acgggcgcga 220201 ccacctcggc cacctcccgg gcgcagtcga cgccccggtg cgggtattcg atggaaatcc 220261 gcatccgacg ggccaggatg tcctcgagat gcagggcgcc ctcggcggcg gcggcgtaag 220321 cggcttccac cttcaaatag cccggtgcct ccgttatcgg gctcaacagg ctgggatcgg 220381 aggccgccat cgctagaacg tcgctgatca gcgaaccata gcggtccagc agatggcgca 220441 cccggtacgg gtgcaggccc tgcagcgcgc cgacgtgttc ggcctgattg accagtgcaa 220501 agtaaccgtc ggcgcccagc aggctgacct tctcggtgat cgacggcgca acgcgggcgg 220561 ggatgaactg cacagcagcg tcgatcgcgt cggccgccat tactcggtag gtggtgtact 220621 tgccaccggc gatggccacc aggcccgccg ccggcacagc cacggcgtgt tcccgggaca 220681 gcttggaggt gtcgtcgctt tccccggcaa gcagcggccg cagcccggcg tacactccgt 220741 caatgtcggc gtgcgtcaac ggggtcgcca acacggcgtt gacagtgccc aggatgtagt 220801 cgatgtcggc cttggtggcc gcggggtgcg ccaggtcgag gttccagtcg gtatcggtgg 220861 ttccgatgat ccagtgactt ccccacggaa tgacaaacat caccgacttc tccgtgcgca 220921 ggatcatcgc gacgtcactg acaatccggt cccgcggcac caccacatgc acgcccttgg 220981 atgcgcgcac ctggaagcgc ccgcgctgtt tggacaacgc ttgaatctca tcggtccaga 221041 ccccggtcgc gttgaccacg acgtggccgc gaacctcggc aaccgcgccg ttctcggagt 221101 cgcggacgcc cacgccgatc acccggtcac cctctcgcaa caaggccact acctgggtgg 221161 agcagcggac aaccgcgccg taatgcgccg cggtgcgcgc gaccgtcatg gtgtgccggg 221221 cgtcgtcgac gacggtgtcg tagtaacgga taccaccgat cagcgagctg cgcttcaagc 221281 cggggctcag tcgcagcgca ccggcgcgag taaaatgccg ttgcgccgga accgatttcg 221341 cgccacccag ccggtcgtaa agaaagatac ccgcggcgat gtagggacgc tcccaccagc 221401 gtttggtcag cgggaacaaa aacggcagcg gcttgaccaa atgcggtgcc agcgtggtca 221461 gcgacagttc acgttcatag agcgcctcac gcaccagccc gaactccagt tgctcgaggt 221521 agcgcagccc gccgtggaac atcttcgagg agcggctcga cgtgccggag gccaagtccc 221581 gcgcctcgac caacgccacc ttgagcccac gggtggcagc atccaaagcg catccggagc 221641 ccactactcc gccgccgatc accacgacgt cgaattgctc ggttccgagt cgcttccagg 221701 cgaccgcgcg ctgtgcaggt cccagcgccg cggcgggcca cccctgcccg ccgtccggtg 221761 cctggattgg gttgctcacg aaaccggctc ctgtcagtta ctcgtcggta ggtggtgtgg 221821 caccaaggct agttgttcag ccgcgtcttg agctgccgtg cagtccagat cgtcgtgcgc 221881 catcagccgg cgggccgcct cggttatcga acccgacaac gatgggtaaa cggccagtgt 221941 ctgggccagc tcgttgacgg tgatgcggtt ctgaacggct acggcgatgg gcaggatcag 222001 ctccgatgcg atcggcgcca ccaccacgcc gccgatcaca acgccggtgg accgccggca 222061 gaagatcttg acgaacccgt gacgcatctc cgacatcttg gcgcgcgcgt tggttcgtaa 222121 cggcagcatg atggtccggg cggccaccga accggcgtcg atgaccgatt gcggcacccc 222181 gaccgcggcg atctcgggcc tggtgaaaac cgtcgcggcc accgtgcgta accggatcgg 222241 gctgacgccc tcccccagcg cgtggtacat cgcgatgcgg ccctgcattg cggcgaccga 222301 cgccaggggc agcaaacccg tgcagtcgcc cgcggcgtag atgccggtcg ccaacgtccg 222361 cgacacccgg tccacggtca ggtaattgcc ccggccaagc tggatgccga cccgttccag 222421 gcccaggccg ctggtgttgg gcaccgaccc gatggtcatc agggcgtggc tgccctcgac 222481 ggtgcgaccg tcggtcatcg tgacgagcac cccggccccg gtgcgggtga ccgatgctgc 222541 ccgggcattt ttgaacagcc ggactccccg ttcggcgaac gactcttcca ggaccagcgc 222601 agcgtcagcg tcctcatacg gcagcacgtg gtcctggctg gccaccaccg tgaccggcac 222661 ccccaattcg gtataggcgt ccacgaactc agcaccggta accccggagc ccaccacgat 222721 gaggtggtcg ggcaacgcgt ccaagtcgta gagctgccgc caggtcagaa tgcgctcacc 222781 gtccggctgg gccgacggca ggatccgcgg gctggcgccg gtggcgacca gcacgacgtc 222841 ggcctcatgc tcactggtgg agccgtcggc ggcggtcgcc ttaatgcgat ggcgcgccag 222901 acccggtgtg gagtcgatca actcgccccg gccggcgatc acctgaaccc ccatgctgag 222961 cagctgggcg gtgatgtcgg ccgactgtgc ggcggccagc gtcttgaccc gggcatggat 223021 ttgcggcaac gagatcttgg cgtcgtcgaa gtcgatatga aagcccaggt gcggcgctcg 223081 gcgcagttcg gtacgcagcc cggtggaggc gatgaacgtc ttcgacggca cacagtcgtc 223141 cagtacggca gccccgccga tgccgtcgca gtcaatcacg gtaacttggg ttgtttccgg 223201 gtgtgaggtg gcggccacca gtgcggcctc gtaaccggcc gggccgccac cgaggatcac 223261 gatgcgggtc accacagccc ataacctagc tcggcgacga tgcacgccgc gcagcggcgt 223321 gaggaggagc cgagcagtcc aacacagctc ggcgacgatg cacgccgcgc agcggcgtga 223381 ggaggagccg agcagtcaag cacagcttga cgatgacccg caccgcagcg cggcgcgatg 223441 ggtaccaccc gagcccccgc cgtctaagct ttcccccgtg ccgctctacg ccgcctacgg 223501 gtcgaacatg catcccgagc agatgctcga gcgcgcaccc cactcgccga tggccggaac 223561 cggctggtta cccgggtggc ggctgacgtt cggcggcgag gacatcggct gggaaggggc 223621 gcttgccacc gtcgtcgaag acccagattc gaaggtgttc gtcgtgctct acgacatgac 223681 cccggcggac gagaagaacc ttgaccggtg ggaaggctcc gagttcggca tccaccagaa 223741 gatccgatgc cgcgtggagc gcatttcctc ggacaccaca acggatcccg tcctcgcgtg 223801 gttgtacgtt ttggacgcct gggagggtgg cctgccgtcg gcccgctatc taggtgtgat 223861 ggccgatgcc gctgagatcg cgggcgcgcc aagtgattac gtacatgact tgcgtactcg 223921 cccggcccgc aacatcggcc cgggaactat tgcctaatta tcgcgagcgc ccaggctaat 223981 gcgcggcggc ctgctcgatg atgttgacca tcacccgcag cccgatcgcc agggctcgct 224041 cgtcgatgtc gaacgtcggc tgatgcaggt ccaactgcag tccgtcaccg gaccacacgc 224101 ccagtcgagc catcgcgccg ggaacctcct ccaaatacca ggagaagtcc tcaccaccgc 224161 cggactgccg ggtatcggcc agcacacctg ggccaatagc ctcaatagcg tgggcgagaa 224221 tgcgtgtcga gatttcctcg ttgaccaccg gcggcacccc ccgacggtat tgcagcgtgt 224281 gctcgatcgc caacggtaat agcaacgccg aaatggcttg gcggacaagc tcctcaaggt 224341 caacccaggt ctgccggctg gccgtgcgaa cagtgccgga cagaactccg gtttgcggaa 224401 tggcgttggc ggccataccc gcgttgaccg cgccccacac cagcacggtg ctgttacgtg 224461 ggtcgatgcg acgcgacagc accccgggca gcccggtgac cagcgtgccg agcccgtaga 224521 cgaggtcggc ggtcaagtgt ggacgcgacg tgtgcccgcc cggcgaatac agcgtgattt 224581 ctatcgagtc ggccgccgac gtgatggggc cttgccgaac ggcgaccttg ccgacttcaa 224641 gccggggatc gcagtgcagg gcgaagatcc gcgacacccc ggccaacgcg ccggccgcga 224701 tcgcgtcgat ggcaccaccg ggcatcagtt cctcggccgc ctggaagatc aaccgcaccc 224761 ccaccggcag ctccggtacc gaagccaatg ccaatgcggc acccagcagg atcgcggtgt 224821 gcgcatcatg gccacaagca tgcgcgacgt tgggcatggt cgaggcgtag ggcgcgccgg 224881 tccgctcggc catcggcagc gcatccatat cggcgcgcag cgcgatccgc ggctgatgct 224941 gaggaccgaa gtcgcaggtg agtcccgttc caccgggcag caccttgggg ttcagccccg 225001 cgtcggctaa ccgctcggcg acgaactggg tagtggcgta ttcctgacgg cccaactccg 225061 gatagcggtg gatgtgccgg cgccagccga ccaggtcgtc gtggtgggcg gctagccatg 225121 attcggcggc gtcggcgagg ctcatcgcgc cgccctgcgc tgctgcgcgg ccagcacccg 225181 gtcacgctca tcaggagtct gcgcgagacg gacaaccgtg cgtgccaaca tgatcgcgcc 225241 gtcaaccacc gcgcggtcgg cgctggcacc agcggaagcg acggtgaagg cccgttggtg 225301 caccgtcgcc gcgccggcgt ccaggccgat caccggatgg atcccgggca gcacctgcgt 225361 cacgttgccc atgtcggtgc tacccagcgg cagctctgcc tccaaggctg gcagcaacgg 225421 ctcgcgcccc agccgctgca tctcctcccg gcacacgtca gccagccacg ggtcgggttt 225481 gagctccgcg tatgccggtg cagcctcgtc gatttcgtat tcgcacccgg cggccagcgc 225541 gccggccgca aagcaggcga acattctggt ctgcagctcg cgcagcgaat ccgattcgac 225601 cgcacgcatc gcatactgca gcctcgcctg cccggggatg acattgaccg cctgcccgcc 225661 gtcggtcaca atgccgtgca ccatttgccc gggcgccaat tgctgtcgaa gtaccccaat 225721 agcgacctgc gccacggtca cggcgtcggc ggcgttaacc cctaggtgcg gcgcgacggc 225781 cgcgtgcgat tccttacccc gatagcgcac ggtgacctcg gacagggcca gtgatcgtgc 225841 gccggcgata tcggtcggcc cgggatggac catcacggcc accgcaacgt catcgaacgt 225901 cccggcctgc agcatcagcg ccttaccgcc gccggactcc tcggcagggg tccccagcag 225961 agccacggtc aagcccaggt cgtccgccac ctcagccagt gccagcgcgg tgcccacagc 226021 ggaggccgca ataatgttgt gcccgcaggc gtgtccgatc ccgggaagcg cgtcgtactc 226081 ggcgcacact ccgacaacca acggtccgct gccgtagtcg gcgcgaaacg ccgtgtccaa 226141 cccaccggcg gccgtggtga tctcgaaacc gcgttcggcg accagcgcct gagccttggc 226201 gcagctgcga tgctcggcga acgccagctc gggctcggcg tggatggcat gggacagctc 226261 gaccagctcg ccaccacggc gccgcaccaa ttcctcgacg cggtcggatg cgctggctgc 226321 tggcatgctc gcagtatctc atcgacgagc acccgctccc cggcgagcgg ctcagttaag 226381 ctcgcccagt gtggctgacc cgcgccccga tcccgacgaa ctggcccggc gggcggcgca 226441 ggtcatcgct gaccgcaccg ggatcggcga acatgacgtc gcggtcgtgc tcgggtcggg 226501 atggttaccg gccgttgcgg cgttgggctc cccgaccacc gtgctgccgc aggccgaact 226561 gcccgggttt gtgccgccaa ccgcagccgg gcatgcgggc gagctactgt ccgtgcccat 226621 cggtgcgcac cgggtgctgg tgctggccgg tcgcatccac gcctacgagg gacacgacct 226681 gcgctacgtc gtgcatccgg ttcgggcggc ccgtgcggca ggggcgcaga ttatggtgct 226741 caccaacgcc gccggtgggc tgcgggcgga ccttcaggtc ggccagccgg tgctgatcag 226801 cgatcacctg aacctgaccg cacgttcgcc actggttggc ggggagttcg tcgacctgac 226861 cgacgcctac tcaccgcgac tgcgggaact cgcccgccaa tccgacccgc agctggccga 226921 aggcgtctac gccggcctgc cggggccgca ctacgagaca ccggcggaga tccggatgtt 226981 gcagacactg ggcgccgacc tggtcggcat gtccacggtg cacgagacca tcgcggcccg 227041 ggcggcgggc gctgaggtac tgggcgtatc cctggtgaca aatctggcgg ccgggatcac 227101 cggcgagccg ctgagccacg ccgaggtgct cgccgccgga gccgcatcgg cgactcggat 227161 gggcgcgctg ctagccgacg tgatcgcccg gttctaagcc gtgacgccag agaattggat 227221 cgcccacgac ccggacccgc agacggccgc cgagctcgcc gcctgcggcc ccgacgagct 227281 gaaagcgcgg ttcagccgcc cactggcgtt cggcaccgcg gggttgcgcg ggcacctgcg 227341 gggcgggccg gacgcgatga acctggcggt ggtgttgcgc gccacctggg cggtggcacg 227401 ggtgctcacg gatcgaggtc tggctggttc gccggtgatc gtggggcgcg acgctcggca 227461 cggctcaccg gcgtttgccg ctgcggccgc cgaagtgctt gccgccgcag gtttttccgt 227521 gctgcttctg cccgatcccg cacccacccc ggtggtggcg ttcgcggtgc ggcacaccgg 227581 cgccgccgct gggatacaga tcacggcgtc acacaacccg gcgaccgaca acggctacaa 227641 ggtctatgtc gacggcggcc ttcagctcct cgcccctacc gaccggcaga tcgaagccgc 227701 gatggccacc gcgcccccgg ccgatcagat cgccaggaag accgtcaacc ccagtgaaaa 227761 ccgcgcctcc gatctgatcg accgttatat ccagcgtgcg gccggggtcc gaaggtgcgc 227821 cggttcggtc cgggtggccc tgacgccgct gcacggggtt ggcggggcga tggccgtcga 227881 gacccttcgg cgagccggtt tcaccgaggt gcataccgtg gcgacgcaat tcgcgccgaa 227941 tcccgacttc cccaccgtga cattgccgaa ccccgaggag cccggagcca ccgacgcact 228001 gctcaccctg gctaccgacg tggacgccga cgtcgcgatc gcgctggatc ccgatgcgga 228061 tcgctgcgcg gtcgggatac ccacggtgtc gggatggcgg atgctgtccg gtgacgaaac 228121 cggttggcta ctaggtgatt acatcttgtc gcaaaccgac gaccgggcgt cgccgccgga 228181 aaccagggtg gtggccagca ccgtggtgtc gtcgcggatg ctggcggcga tcgccgcgca 228241 tcacgctgcc gtgcacgtgg agaccctcac cggctttaag tggctggcgc gcgccgatgc 228301 gaacctgccc ggcaccctgg tgtacgccta cgaggaagcg atcgggcact gcgtcgaccc 228361 caccgcggtg cgtgacaaag acggcatcag cgccgcggtg ttggtgtgcg atctggtggc 228421 cgcgctcaaa ggccagggtc gttcggtgac cgacgcgctc gacgagctcg cccgatgcta 228481 cggcgtgcat gaggttgccg ccctgtcacg ccccgtgagc ggcgccgtcg agaccaccga 228541 cctgatgcga cggctccgcg aggacccgcc gcgtcggctg gccggtttcc ccgccacggt 228601 caccgatatc ggcgacacgc tgatcctcac cggcggcgac gacaacatgt tggtcagggt 228661 ggcggtgcgg ccttctggaa cagaaccgaa gctgaagtgc tacttggaga ttcgctgcgc 228721 ggtgaccggt gacctaccag ctgcccgaca gctggtgcgg gcgaggatcg atgagctgtc 228781 ggctagcgtg cggcggtggt ggtgactcag cgcgggccga actggcgatc gccggcatcg 228841 ccgagaccgg gcacaatgta ggcgacctcg ttaagccctt cgtcgatggc cgcagtgaac 228901 aaccgcacgt ttggcgcagc cttctgcagc gccgcgattc cttctggcgc cgcaaccaca 228961 cacagcaccg tgatatccgc tgcaccgcgc gagatcagca gaccgagggt gtgcgtcatc 229021 gacccgccgg tggccaccat cgggtcaagc accatgaccg gtacatccgt caggtcgtcg 229081 ggcagcgagt ccagatacgg caccggctgg tgggtttgct cgtcgcgggc gacaccgaca 229141 aagccaacgt gcgcctccgg caaggcggca tgcgcctcgt cgaccatccc caaccccgcc 229201 cgcaacacag gaaccagcag gggtggcttg gttagccgcg acccgaccgt ctcggccagc 229261 ggcgtacgga tcgggactgg ctcgcagggc gcatcgcggg tggcctcata gatcaacagc 229321 agcgtgagct cgcgcagcgc tgcccggaag ccggcgttgt cggtgcgttc gtcacgcagc 229381 gtggtcagtc gggccgcggc cagtgggtgg tcaacgacat ggacctgcac ggcgttgaac 229441 cctatataac aatcgtggct cggtccccta aaagggggct gatacgggtg cgtccatccg 229501 cgcgaccggt caaccccgtc catatactcc cggcatgctc cgcggaatcc aggctctcag 229561 ccggcccctg accagggtat accgtgcctt ggcggtgatc ggtgtcctgg cagcatcgtt 229621 gctggcctca tgggtcggcg ctgtcccaca agtgggtctg gcagcgagtg ccctgccgac 229681 cttcgcgcac gtggtcatcg tggtggagga gaaccgctcg caggccgcca tcatcggtaa 229741 caagtcggct cccttcatca attcgctggc cgccaacggc gcgatgatgg cccaggcgtt 229801 cgccgaaaca cacccgagcg aaccgaacta cctggcactg ttcgctggca acacattcgg 229861 gttgacgaag aacacctgcc ccgtcaacgg cggcgcgctg cccaacctgg gttctgagtt 229921 gctcagcgcc ggttacacat tcatggggtt cgccgaagac ttgcctgcgg tcggctccac 229981 ggtgtgcagt gcgggcaaat acgcacgcaa acacgtgccg tgggtcaact tcagtaacgt 230041 gccgacgaca ctgtcggtgc cgttttcggc atttccgaag ccgcagaatt accccggcct 230101 gccgacggtg tcgtttgtca tccctaacgc cgacaacgac atgcacgacg gctcgatcgc 230161 ccaaggcgac gcctggctga accgccacct gtcggcatat gccaactggg ccaagacaaa 230221 caacagcctg ctcgttgtga cctgggacga agacgacggc agcagccgca atcagatccc 230281 gacggtgttc tacggcgcgc acgtgcggcc cggaacttac aacgagacca tcagccacta 230341 caacgtgctg tccacattgg agcagatcta cggactgccc aagacgggtt atgcgaccaa 230401 tgctccgcca ataaccgata tttggggcga ctagccgccg tcgctattct gtgccgcatg 230461 gttgctgacc tcgtacccat ccgcttgagc ctgtccgctg gtgaccgcta cacgctgtgg 230521 gctcctcgct ggcgggatgc cggcgacgag tgggaggcgt tcctgggcaa agacgacgac 230581 ctgtatggct tcgagagcgt ctctgacctg gtcgcgttcg tgcgcaccga caccgagaac 230641 gacctggtcg accacccggc atggcaagac ctgaccggag cccacgcgca caacctcaat 230701 ccggccgaag acaatcagtt cgacctggtc gtcgtcgagg aactgctggc tgagaagccg 230761 acggcggagt cagtggccgc gctggccgcc tcattggcga tcgtatccgc catcggatcg 230821 gtgtgcgaac tggcggcagt gtcgaagttc ttcaacggca atcccatcct gggcacggtt 230881 tccggcgggc tcgaacactt caccggaaaa gccggcaata aacgctggaa ttcgattgcc 230941 gaggtcatcg gacgcagctg ggacgacgtg ctcgcggcca tcgacgagat catcagcacc 231001 cccgaggtcg acgctgagct gtcggaaaag gtcgccgagg agttggcgga ggagcccgag 231061 ggcgccgagg aagtggcggc ggaggtggag gccacgcagg acacgcagga ggcggccgag 231121 tccgacgacg aggaagccga cgcacccggt gacagtgtcg tactgggcgg cgatcgggac 231181 ttctggttgc aggtgggcat cgacccgatc cagatcatga cgggcaccgc caccttctac 231241 acgcttcgct gttacctgga tgatcgaccg atcttcctgg gccgcaatgg tcggatcagt 231301 gtgtttggct ccgagcgggc attggcccgc tatcttgccg atgagcacga ccacgacttg 231361 tcggacctga gcacctacga cgacatccgc acggccgcca ccgacggctc gctggcggtt 231421 gccgttaccg acgacaacgt ctatgtgctc agtgggctgg tcgacgattt tgccgacggg 231481 ccggacgcgg tggaccgtga gcagctcgac ctggccgtcg agctgctccg cgatatcggc 231541 gactactccg aggacagcgc agtcgacaag gcactcgaga caacccgccc gctgggccag 231601 ctggtggcct atgtgttgga cccccactcg gtcggcaaac ccacggcccc gtatgcggcg 231661 gctgtccgtg aatgggagaa attggaaagg ttcgtggagt cgcggctcag gcgcgaatag 231721 gcaccgtcag ccggcgaagg ctagccgccg cggcgcttgc cgatgtccag ggcacacgcg 231781 gcgaggatcg catcccagtc ttcgatgttg aaatggccct tgccgtgcgc ccagtgcaaa 231841 tcaacgtgcg gaatcgcgcg ctgcaggtat tcgcccatgg cgcgtggcac gaaggagtca 231901 cgatcaccca gccagatatg ggtaggcacg gccacctcgg cgaggtcgaa accccacggc 231961 cgaaattgca gaaatgattc ataggctgcg ccgcggctgc cctgtcggaa cgcttcgagc 232021 tggatggcgc gcaggtggcg gccgaagcgt tcgtcgctca gcaggtgctt gtcggccgcg 232081 gggaccgcag ccgccaacaa cgtagaaaac agcccgggcg tgtatttcgc gcaccagccg 232141 agcggggcaa acaacgcacc gaatagccgc ggcccgcttc gcgccaaccg cgcgtagcac 232201 cgatcggccg cgttgaggct gcgcatgata tccggcgtcg ccagtggacc ccatggtccg 232261 agcgcgccga cgaacgctag tcgggtccgc gggatgacgg caccgcaggc gaataggtgc 232321 ggtcccgcgc ccgaatgccc gaccaccccg aactcctcca gctcgaacgc gtcagccagg 232381 gcacacacgt ccgcgggcca atcgcgaaaa ttgcgtcccg cttgaaaggt ggagcgcccg 232441 tacccgggcc gatcaatcgc tatcagtcgg aagccggtgc gccgcgcggc accatcggcg 232501 aaggccccct cgagccgcga acttggcgtg ccgtggaagt agaacgctgg gtagccggtg 232561 ctatcacccc attccaggta ggcaagcgcc cgcccgtcgg gcagcatgag cacatccgcc 232621 tcgtcggtgc gaatgcgctc gggcagcgat ggcggtggcc cggtcaagag cacaccagcg 232681 atggtatgcc gatcagagtc gattcagcgc gcgtgccatg cacgagtcct cgaggaaccg 232741 atagcgccta ggctgggact gccgcaacca cagccgatcc agcgccgaac gcacgatccg 232801 gcgaacgggt gtgcgggtaa cagccttgtc gatgtcgatg gtggaggcgc tgtcgccgtt 232861 catgacaggt tcccttcaag cgtcctgcaa gcggttgcca aagccgtcgc ctattttctg 232921 tcatcggacg gcgcgatcca tcggcacggg agcgtaaatc tgccccgccg ggggtcgtag 232981 cttgccgggg gcacgcccgg gtttatacgc gtattcgctg atgcggcccg gtcaacgagc 233041 gctatgcgcc gccaccggca gccgggggcg gcggcgcagc accgggatcg tcaagcacgg 233101 gaccttcgag gatgggtccg gggtagtcgc ggctgtggtc ggggccgtcg ctgtcgcggt 233161 ggaagtcgtc atggcaggtg tagggatccc agttgggccc ccatgcgggg tcgaaaggct 233221 gccccgggca ccagtagtag tcgggcaccg gcgcggtttg ggctgcggac tgcgcgccga 233281 ccccgagacc cgccacaccc gtggccagga tgcacgccgc cagcatgagc gtgcggcacg 233341 cgaaccggta catgcgatga cggtacgaaa gcgatctggc aagcaactgg acgctaggtg 233401 cgatatacca gagaacttgc tgattactcg ctgtgaccca tgagcgccgc gaaccgcggc 233461 ttgatcactt cgtcgattat cgccagccgc tggtcgaacg gaatgaacgc ggatttcatc 233521 gcattgacgg tgaagcgcgc caggtcgctc cagccataac cgaaagcctc taccaaacga 233581 tgcatttcga ggctcatcga ggtgtcgctc atcagccggt tgtcggtatt gacggtcacc 233641 cggaaccggg cccgagccag taggtcgaac ggatgctcgg cgatgcttgc gaccgcgccg 233701 gtctgcacgt tggagctggg gcacagctcc agcggaattc gcttgtcccg caggatagct 233761 gccagccgac ccaactggaa accgccgtcg gcatccacgt cgatgtcgtc gacgatccgc 233821 accccgtgac ccagccggtc ggcaccgcag aaggcgatcg cctcgtggat ggacggcaac 233881 ccgaacgcct caccggcatg aatcgtgaag cgcgcgttgt gatcacgcat gtactcgaat 233941 gcatccaagt gccgggttgg cgggtggccg gcctccgcgc cggcgatgtc gaatccgaca 234001 actcccttgt cccggaaccg gatcgccaac tctgcgatct cccgggacat tgcggcgtgc 234061 cgcatcgcgg tgaccagaca gcggacggtg atgggttgac catcggcggc acacgccttc 234121 tcgccggcgg cgaagcccgt cagaacggtg tcgacgacgt cgtcgaacga cagcccgcag 234181 ctgatgtgca gctccggcgc gaaccgcacc tcggcataga ccaccgaatc ggcggccagg 234241 tcttgcgcgc attcgaaggc gacccgatac aaggcctcgg gagtctgcat caccgccacc 234301 gtgtgcgaaa acggttccag gtagcgctcc agcgagccgc tgtgcgactg ggtgcgaaac 234361 caacttgcca gcgcgtcgac gtcagttgcc ggcaggtcgt cgtatccgac ctgcccggca 234421 atgtccagca cggtggccgg ccgcagcccg ccgtcgaggt gatcgtgcag caacgccttg 234481 ggggctagcc tgatcgtctg cagggtcggc gcagcggtca tcagacgatc cgatcgacga 234541 ttagcggccg cacctgcggc ggactgtccc ggatactcca accgccggcc agctcggctc 234601 gcgccgcacc aaagcgctcg ggagcattcg tgtagagggt gaacaacggc tcaccgacca 234661 caaccggctc ccccgggcgg cgatgaatcc gcacccccgc accgtgctgt acgcgtgcgc 234721 ccgggcggga cctgcccgca ccgagtcgcc atgccgctaa ccccactgcc atcgcatcga 234781 tgtcgcccat tgtgccgctc gcgcccgccg tgacggtttc cgaatgcgaa ccgatcggca 234841 acggtttcga caagtcacct ccctgcgcgg caaccaaccg gcgaaaccgg tccattgcgg 234901 tgccgtcccg cagcgtctgg gccgggtccc ggccgtggat cccggcaagc tcgagcatct 234961 cgccggccag ccgcaacgtc agctccacca cgtcgggcgg tccgccgccg gccagcacct 235021 ccagcgcctc ggccacctcg agcgcattgc cgacggttcg acccagcggg cagttcatct 235081 ccgtcagcag ggcacgggtg ggcacgccat gcgccgcgcc cagttcgacc atggtgtgcg 235141 caagttcgcg cgcctgcact ggcgacctca tgaaggcccc ggaaccaacc ttgacgtcga 235201 gcaccagtgc acccgcaccc tcagccagct tcttgctcat aatcgaactg gcgatcaacg 235261 gcagcgattc gacggtgccg gtaatgtcgc gcagcgcata cagcttggca tcggctggcg 235321 ccagctggcc ggcggcgaag atcgcggcgc cgacgtcgca aagctgctcg cgcacccgct 235381 ggttggacag attcgcggtg aacccggtga tggattccag cttgtccagg gtgccgccgg 235441 tgtggccgag tccgcggccc gacgcctggg gcactgcgcc accgcaggcg gcgacgacgg 235501 gcaccaatgg cagcgtgatt ttgtcaccta ccccgccggt ggaatgcttg tccacggtcg 235561 ctagtggcag atcggtgaaa tccagccggg cacccgaggc cagcatggcc gccgtccatc 235621 tggcgatctc gccgcggtcc atgccccgcc aaacgatcgc catcagcagc gccgacatct 235681 gttcgtcggc gacccggccg tcggtatagg ccttgacgac ccagtcgatg gcggcgtcgg 235741 acaaccggcc gccgtcacgt ttggtgcgga tgacggtcgg ggcgtcgaat gcgaagtcgg 235801 tcaccggcgt tcccggggga ggtcgtcgag gccgaaggcg tcgggcagca ggtcgccgag 235861 ccggcggggt cgcaccggat ggtcgatcag tagctcggaa cccccgtgtt cgagcagcac 235921 ctgacggcat cgcccgcacg gcatcagcac ggatccatgg ccgtcgacgc aggccagcgc 235981 gagcagccgg ccgccgccgg tcgaatgcag ggcgcacacc accgcacatt cggcgcacaa 236041 agtcaagcca tacgagacgt tttccacgtt gcatccggtc accacgcgac catcgtcgac 236101 cagtgcggcc gcacccaccg caaaccgcga atacggcaca taggctccgg ctgctgcctg 236161 ggttgcattg ccccgcagca tattccaatc gacatcaggc attcggcaac cccgctcgtc 236221 gatgggccga ctaagaaaag ccagcctaac cccggatcca cacacgatcc cgatcggact 236281 gttcgacacc gcgggcaacc tggccaagtt aagctcgatt gcccggctct agctgttcga 236341 tagtgctttt aaggggtttg ccagcggtga atacaacggc gacaaccgtc tcgcgcgggc 236401 ggcggccacc tcggaccctg tatcggggag atcccggtat gtggtcgtgg gtatgccatc 236461 gcatcagcgg cgcgacgatt ttcttcttcc tgtttgtcca tgtcctggac gccgccatgc 236521 tgcgggtgag cccgcagacc tacaacgcgg tgctggcgac ctacaagacc ccgatcgtcg 236581 gcctgatgga gtacggccta gtcgccgcgg tcctttttca cgcactgaac gggattcggg 236641 tcatcttgat cgatttctgg tcggaaggcc cgcgctatca gcggctgatg ttgtggatca 236701 tcggcagcgt cttcctcttg ctgatggttc cggcaggcgt ggtggtgggc atccacatgt 236761 gggagcactt ccgatgagcg ccccggtcag acagcgcagc catgaccgtc cagccagcct 236821 ggacaaccca cgatcaccac ggcggcgtgc cggcatgccc aacttcgaga aattcgcctg 236881 gctgttcatg cggttttccg gtgttgtgtt ggtgttcctg gcgatcgggc acgtgttcat 236941 catgctgatg tgggacaacg gcgtgtatcg cctggacttc aacttcgttg cccaacgctg 237001 ggcgtcgccg ttctggcaga cctgggatct gctgttgttg tggctggcgc agctgcacgg 237061 cggcaacggt ctgcgcacca tcattgacga ctacagccgc aaagacacca cccgattctg 237121 gctgaactcg ttgctggtgt tgtccatgct gttcaccctg atgctgggaa cctacgtgat 237181 agtgacattc gacccgaaca tctcctgaaa ggcccggaag gagcacatga tcacgccacc 237241 tctcccccgc aagcgggcgg tacccccacc tcatcgctgc ggccccctcg tcgcttcgcg 237301 gctgggggtg cccccactgc atcgtcggcg gcggcgttga tctgccaaca ccgatacgac 237361 gtggtgatcg tcggcgcggg cggtgccggg atgcgcgccg cggtcgaggc gggtccgcgg 237421 gtgcgtaccg cggtgctgac caagctgtat cccacccgca gccacaccgg cgcggcccag 237481 ggcggcatgt gcgccgcgct ggccaacgtc gaggacgaca actgggagtg gcacacgttc 237541 gacaccgtca agggcggcga ctatctcgcc gaccaggacg ccgtggagat catgtgcaag 237601 gaagccatcg acgcggtgct cgacctggag aagatgggga tgccgttcaa ccgcaccccc 237661 gagggccgca tcgaccagcg ccgcttcggc gggcacaccc gcgaccacgg caaggccccg 237721 gtgcgccggg cctgctacgc ggccgatcgc accggccaca tgattctgca gacgctgtat 237781 cagaactgcg tcaagcacga cgtcgagttc ttcaacgagt tttacgcgct ggatttggct 237841 ttgactcaaa cgccgtcggg cccggtggcc accggggtga tcgcctacga gctagcgacc 237901 ggtgacatcc atgtctttca cgccaaggcc gtcgtgatcg cgaccggcgg ctcgggccgc 237961 atgtataaga ccacgtccaa cgcacacacc ctgaccggcg acggcatcgg catcgtgttc 238021 cgcaagggac ttcccttgga ggacatggag tttcaccagt ttcaccctac cggcctggcc 238081 ggtctgggca tcttaatctc cgaagcggtg cgcggcgaag gcggccggct gctcaacggg 238141 gaaggtgagc gtttcatgga gcgctacgcc ccgacgatcg tcgacctagc gccccgcgac 238201 atcgtcgccc gctcgatggt gctggaagtg ctggagggac gcggcgccgg accgctcaag 238261 gactacgtct acatcgacgt ccgccacctg ggcgaggaag tgctcgaggc caagctgccc 238321 gacatcaccg agttcgcccg cacctacctg ggcgtggatc cggtcaccga gctggtgccg 238381 gtctacccga cgtgccacta cctgatgggc ggcatcccga ccacagtcac cgggcaggtg 238441 ctgcgggaca acaccagcgt tgtcccgggc ctgtatgcgg ccggcgagtg cgcgtgcgtg 238501 tcggtgcatg gcgccaaccg gctgggcacc aactcgctgt tggatatcaa cgtcttcggt 238561 cgtcgggccg gcatcgccgc cgccagttat gcgcagggtc acgactttgt cgacatgccg 238621 cccaacccgg aggccatggt ggtgggctgg gtcagcgaca tcctgtccga acacggaaac 238681 gagcgggtcg ccgacattcg cggggcgctg cagcagtcga tggacaacaa cgccgcggtg 238741 ttccgcaccg aggagaccct gaagcaggcg ctcaccgaca tccacgcgct caaggagcgc 238801 tactcccgaa tcacggtgca cgacaagggg aaacgcttca acaccgacct gctggaagcc 238861 atcgagctgg gatttttact ggagctggcc gaggtcacgg tggtcggcgc tttgaatcgc 238921 aaggagtccc gcggcggtca cgcccgcgag gactatccca accgcgacga cgtcaactac 238981 atgcgacaca ccatggccta caaggaaatt ggggccgata aggagggccc cgagctgcgc 239041 agcgatgtcc gccttgattt caaacccgtc gtgcagaccc gttacgaacc caaggaacgg 239101 aagtactaat gagcgtcgag ccggacgtcg aaactttgga tccgccccta ccgccggtac 239161 cggacggcgc ggtgatggtg accgtcaaga tcgcccggtt caaccccgac gaccccgacg 239221 cgttcgcggc caccggcggc tggcagagct tccgggtgcc ctgtttgccc agcgatcggc 239281 tgctcaacct gctcatctac atcaagggct acctcgacgg cacgctcacc ttccggcgat 239341 cctgcgccca tggggtgtgc ggctctgatg ccatgcgcat caacggggtg aaccggctgg 239401 cctgcaaggt gctgatgcgt gacctgctgc cgaagaagaa gggcaaatcg ttgaccgtca 239461 cggtcgagcc gatccgcggg ctgccggtgg aaaaggacct ggtggtcgac atggagccgt 239521 tcttcgacgc ctaccgggcg atcaaaccgt acctgatcac cagcggcaac ccgcccaccc 239581 gcgaacggat ccagagcccg accgaccgcg cccgctacga cgacaccacc aagtgcatcc 239641 tgtgcgcgtg ctgcaccacc agctgcccgg tgttctggca cgagggcagc tacttcggcc 239701 cggcggcgat cgtcaacgcg caccgcttca tcttcgacag ccgcgacgag gccgccgccg 239761 agcgcctcga catcctcaac gaggtcgacg gggtgtggcg ctgccgcacc acgttcaact 239821 gcaccgaatc ctgcccacgg ggcattgagg tgaccaaggc gatccaggag gtcaagcgcg 239881 cgctgatgtt cacccgctga gggcttgcgc gagcagacgc aaaatcgccc gaaaaccagt 239941 ggttttgggc gattttgcgt ctgctcgcgc agccgggtct acagcgttgc caggtgctgt 240001 ttggttgcgc caggaaccgc agtcaacgca atcgactgat cgaaggtgac aaatcggcca 240061 tcatgagcga ccgcgagggc cagcaagtac gcgtcggtga cctgtttggg gctgtgcagg 240121 cgggaacgat cgatgacctt tgagtcgaga atgctgacgg tgcaggacca gaactcgtga 240181 tagcgcgtgt gcgtcgcacg agccaacaag tcgatggcat gggctaccga gattgggctg 240241 ggatagcgcg gttggctgat gacgcggacg aacccgtttt gggtgatcgc acaggaagcc 240301 catccccgct cgatctgccc ggtgatccac gctcgggcgc gctcgtggtc gacgtgatcg 240361 cggtccaaca gcgccagtag cacgttgacg tccaacagcg ctcgcatcga tcacacggcc 240421 tcctcgtcac gaagccgatc gatcagcgcg ttcgataccg ctccaccgcg atgaggcagg 240481 ggttcgaagc catgaaaggc gtcctcctgg ctcgccgcag gctggggatt ctggttggtt 240541 aacgcttgcc gggccagatc cgacaggatt tcacccgcgg tgcgcttctc cctgcgtgcc 240601 cgttccttca cggccagcaa tacatcgtcg tcgatggaca acgtggtgcg catgcatcag 240661 atgctatcgc accaatctgg gcgcaacgcg tctacaggat ggccagcgct cgcggcattg 240721 agaatctcct tcgtgggtgc actcccacgc gaggtagggg ccgacgacca ccatctatgc 240781 ccctggcaac ggtgagcgcc gcgcgatcat gatccgcgac ggcgccgaat cgcagttacc 240841 ctgcccctcg tgtacaacgg tgaagtcggc aggaagcaga cacgctggct ctcccggctt 240901 gacacgtcgc ttcgcgctgg ctgtgcccgc ctcggcgcca ctgagagcca gcgactccca 240961 tgccaatacg ccgcctggca tcaccgcctc acaggcgcgg tgaaatatcg ccgcatccca 241021 aaagagcctg ctgagcacca gcgcgaaacg cgtctcgccg ggttcccagc agcccaagtc 241081 ggcctgcacg aggttgagcc gatcggccac gcctcgacgc acggcctcgc tgtccagctg 241141 cagcagcgcg acatcggaca catcgattgc ggtgacctgg cggccgtggg cggccaacgc 241201 cagtgcggta cccgatcgac cgctggctaa ctccagaacg ggaccgtccg gaacgcctgc 241261 tctgaggaca tcggcgagcc aaggcaccgg ggcaaacggc gcgtgcgccg aacccgcgcg 241321 ttcgtatcgc gcgttccagt cgacgcggtt ggggtgctcc cgcagcgccg gatccgtctg 241381 cacgctcatg gccgattggc cacccactca acaccgtcga gtgcgaactc cttcttccat 241441 atcggcacat cctgtttgag ccgctcgatg cacatgcgag cggcgtcgaa cgcggccgcg 241501 cggtgaggag ccgaagcacc gatgacaacc gccgcatcac cgatgcgcaa ttcaccggtc 241561 cggtgtgcca cggcaactcg cacaccgtcg gcctgtcgtt cacactcttc gatgatgtcc 241621 atcagcgtgc ggtgcaccat ggccggatag gcctcgtagt acaacttggt cacttcgtgg 241681 ccgttgttgt tgttacgcac ggtacccacg aagatgacgg cgccgccctg ggaaggtcca 241741 gatatcgcgt tgagcacttc atcgacgctc agcggctcat cggtgagccg gcagtagaca 241801 tcggagcccc cggcaacctg cggtatgaac gccaccgtgt cgccatcgtc gagaatcgtt 241861 gatgctggcg ctatggattc gttaacggcc atccgcactc gcttgcgaaa atcagcaagt 241921 ggcggatagt cgatttgcaa ttggtcgact aagccgtcga cggtggtgcc gctttcgagt 241981 gagatcttct cgtgagcgac cttgcacgct tcgcgaaccg cgccaaagta gagcacattg 242041 acagtaatca ttcaacatcc atcctcggtg gagccaccat cgctgggttt gacgtccgcg 242101 tcgtgccgcc ggtaatgacc cgatcggcca ccgctttttt cgtccaatct gatatccgtg 242161 atcgtcatgg cacggtcgac tgctttgcac atgtcgtaaa ccgtgagcgc tgtcaccgta 242221 acggcggtca acgcctccat ctccacaccc gtacgtgcca ccgtggtcac cgtcgccgca 242281 atcgagagcc ggtccgcgcc ctgcggctcg agcgtgacgg tgaccgcctc gatccccagc 242341 gggtgacaca gcgggataag ctcaccggtc cgtttggccg ccataatgcc ggctatccgt 242401 gcggtcgcta tgacatcgcc ctttgccgcg gtgccgtgac agatcatgtc cagggtcgac 242461 ggtttcatca ggacggcccc ggatgcccgc gctcgccgca aggtcaccgc cttcgccgac 242521 acatcgacca ttcgggcggc gccttgttca tcaaggtggg taagcacccc atcgtggtcg 242581 ttcaccgtgc cacctgctgg ctgcattgct catcgtgcac tgcgctgaaa gcctcggcga 242641 ggtcgaagtc gacgcgagtc aaacagtgca tctggcgcgt ccaacaagtc aaccgcaccg 242701 accgcttgtt atggacactg aaccgccccg gcatgtccgg agactccagt tcttggaaag 242761 gatggggtca tgtcaggtgg ttcatcgagg aggtacccgc cggagctgcg tgagcgggcg 242821 gtgcggatgg tcgcagagat ccgcggtcag cacgattcgg agtgggcagc gatcagtgag 242881 gtcgcccgtc tacttggtgt tggctgcgcg gagacggtgc gtaagtgggt gcgccaggcg 242941 caggtcgatg ccggcgcacg gcccgggacc acgaccgaag aatccgctga gctgaagcgc 243001 ttgcggcggg acaacgccga attgcgaagg gcgaacgcga ttttaaagac cgcgtcggct 243061 ttcttcgcgg ccgagctcga ccggccagca cgctaattac ccggttcatc gccgatcatc 243121 agggccaccg cgagggcccc gatggtttgc ggtggggtgt cgagtcgatc tgcacacagc 243181 tgaccgagct gggtgtgccg atcgccccat cgacctacta cgaccacatc aaccgggagc 243241 ccagccgccg cgagctgcgc gatggcgaac tcaaggagca catcagccgc gtccacgccg 243301 ccaactacgg tgtttacggt gcccgcaaag tgtggctaac cctgaaccgt gagggcatcg 243361 aggtggccag atgcaccgtc gaacggctga tgaccaaact cggcctgtcc gggaccaccc 243421 gcggcaaagc ccgcaggacc acgatcgctg atccggccac agcccgtccc gccgatctcg 243481 tccagcgccg cttcggacca ccagcaccta accggctgtg ggtagcagac ctcacctatg 243541 tgtcgacctg ggcagggttc gcctacgtgg cctttgtcac cgacgcctac gctcgcagga 243601 tcctgggctg gcgggtcgct tccacgatgg ccacctccat ggtcctcgac gcgatcgagc 243661 aagccatctg gacccgccaa caagaaggcg tactcgacct gaaagacgtt atccaccata 243721 cggatagggg atctcagtac acatcgatcc ggttcagcga gcggctcgcc gaggcaggca 243781 tccaaccgtc ggtcggagcg gtcggaagct cctatgacaa tgcactagcc gagacgatca 243841 acggcctata caagaccgag ctgatcaaac ccggcaagcc ctggcggtcc atcgaggatg 243901 tcgagttggc caccgcgcgc tgggtcgact ggttcaacca tcgccgcctc taccagtact 243961 gcggcgacgt cccgccggtc gaactcgagg ctgcctacta cgctcaacgc cagagaccag 244021 ccgccggctg aggtctcaga tcagagagtc tccggactca ccggggcggt tcagaggcaa 244081 ccaccatggt tgttgttgga accgatgcgc acaagtacag ccacaccttt gtggccaccg 244141 acgaagtggg tcgccaactc ggtgagaaga ccgtcaaggc caccacggcc gggcacgcca 244201 cagccatcat gtgggcccgt gaacagttcg gcctcgagct gatctggggc atcgaggact 244261 gccgcaacat gtcggcgcgt ctggagcgtg acctactggc ggccggccag caggtggtgc 244321 gggtacccac caagctgatg gcccagaccc gcaagtcggc gcgcagtcgg ggcaagtcgg 244381 atccgatcga tgcgctggcg gtggcgcggg cggtgctgcg tgaaaccgac ctacccctgg 244441 ccacccacga cgagacgtcg cgggagttga agttgttgac tgaccgtcga gatgtccttg 244501 tggcccaacg cacgtcggcg atcaaccggt tgcgctggct cgtccatgaa ctcgatcccg 244561 agcgggcacc ggcagcacgc tcgctcgatg ccgccaagca ccagcaggcc ctgcggacct 244621 ggctggacac ccagccagga ttggtcgccg aactcgcgcg cgccgagctg accgacatca 244681 tccggctcac cggcgagatc aacaccctag cccagcgcat cagcgcccga gtccaccagg 244741 tcgcccccgc actgctggaa atccctggct gcgcggagct gactgcagcc aaaatcgtcg 244801 gcgaagccgc cggagtgacc cggttcaaaa gcgaagccgc cttcgcctgc catgccgcag 244861 tggctcccat cccggtgtgg tcgggcaaca ccgccggcca gatgcggctc agccgctcgg 244921 gcaaccgcca gctcaacgcc gccctacacc gcatcgcact gacccaaatc cggatgaccg 244981 acagccgggg ccaggcctac taccaaaggc tgcaagacgc cgggaaaacc aaacgcgcag 245041 cactacgctg cctcaaacgc cgcctagccc gcaccgtctt ccaggccctg cgcaccgtcc 245101 accagcccag ctccgaacac acccaacccg cggccgcttg ccataggagc tattgctcgt 245161 cacacctcgg cgagccacct cgtctaacgg atatgacaca gaaaacccgc atccagcccc 245221 tacctcccaa gcgagccggc ctgttgatcc gcgcactgta tcggatcgcc aagcggcgct 245281 tcggcgaagt tcccgagccg ttcacggtca ccgcacatca tcggcggctg ctgatcgcca 245341 atgtggtgca cgaagccctg ctgcagcgag cgtcgcggaa gctaccgccc agcgtccgtg 245401 agctggcggt gttttggacc gcccgcagca tcggctgctc gtggtgcgtg gacttcggag 245461 ccatgctgca gcgcctggac gggctggacg tggacaggct cacggacatc gacaattacg 245521 ccacctcatc gaaattcagc gacgacgaac gcgccgccat cgcctacgcc gaggcgatga 245581 ccgcagaccc gcattcggtg accgacgagc aggtggccga cctgcgggcc cgcttcggcg 245641 aggccggcgt gatcgagctg acttaccaga tcggcgtgga gaacatgcga gcccggatga 245701 attcggcgct gggcatcacc gagcaaggct tcaattccgg tgatgcctgc cgcgtcccgt 245761 gggctgcgcc cgacgttcct tcagcggaga gccggtgaac ttgtcgggat tggcgatatc 245821 ccacagcgcg cacacctttc cgtcgcgcac ggttatcgcg gtgatccgcg gcgccatcgc 245881 ccgatacccg tcgaccccgg gtaagcccgc cgtgtaggcg ccgagctctc cgttgaccag 245941 cgccagctga ttcgcgccga agagccccgg gccgtaacgc tggaccagcc cgagtatgaa 246001 ccggaccacc ttgtcggatc cgcggacggc ccgtaccgct gtgggcgcct tgccattcga 246061 atcgccggta aacgtcacgt cgggatgcag cagcgacacc accgtgtcca ggtcaccagc 246121 ggccatggcg gccatcagcc ggccgaccac ctcgttgtgg gccggatccg gatcccccga 246181 tatcagggcg ggctgcgccg tgacggcctt gcgggcccgc gacgccagct ggcgcgcggc 246241 ggcctcgctg gttcccagca cctcggccac ttcggcaaac ggcacggcga acccgtcgtg 246301 cagcacgaac gcgacccgct gatcggggcg cagccgctcc agcaccacca tggccgcgaa 246361 cctggcgtcc tcggcggcca ccacggcggc caacggatcg gtcgcgtcca agccggtgac 246421 caccggttcg ggcagccagg tgccggtgta ggtctcccgc cggtgcgccg ccgacctcaa 246481 cttgtccaga cccagccggc tcaccacggt ggtcagccag gcccgcgggt cggcgatcac 246541 ggtgtccggt gagtcccagc gcagccaggc ctcctgcacg atgtcctcag catcggcgac 246601 cgtgccggtc agcctgtagg cgaccgacat gagatgctgt cgcagtgcct cgaattcgga 246661 aacctccatc gaggtcattg cccgagccta gcgctgcgct cgccaacacg acgacacgaa 246721 acctttggtt gcacttcgcc cggcacggtg ccggcatcca acacccggtc atcgtccgcg 246781 gcgacggcgt caccatcttc gacgaccgcg gcaagagcta tctggacgcc ttgtccgggc 246841 tgttcgtggt gcaggtcggt tacggccggg ccgaactcgc cgaggcggcc gcgcggcaag 246901 ccggcacgct ggggtatttc ccgctctggg ggtatgccac cccgccggcg atcgagctcg 246961 ccgagcgcct ggcccgctac gcgcccgggg acctaaaccg ggtgtttttc accagcggcg 247021 gcaccgaggc cgtcgaaacc gcctggaagg tggccaagca gtacttcaag ctcaccggca 247081 aaccgggcaa acaaaaggtc atttcacgct cgatcgccta ccacggcacc acccagggcg 247141 cgctggcgat caccggcctg ccattgttca aggcgccatt cgaaccgctg acgccgggcg 247201 gcttccgggt gcccaacacc aatttctacc gagcaccgtt gcacaccgac ctcaaagagt 247261 tcgggcgatg ggctgctgac cggatcgccg aggccatcga gttcgaaggc cccgacaccg 247321 tggccgcggt gtttttggag ccggtgcaga acgcgggcgg ctgcatcccg gcgccgccgg 247381 gttatttcga acgggtccgc gagatctgtg accgctacga cgtgctgctg gtctccgacg 247441 aggtgatctg tgcgttcggc cggatcgggt cgatgttcgc ctgtgaagac ctcggctacg 247501 tgcccgacat gatcacctgc gccaagggcc tgacgtcggg ctactcgccg ctgggcgcga 247561 tgatcgccag cgaccggttg ttcgaaccgt tcaacgacgg cgagacgatg ttcgcacacg 247621 gctacacgtt tggcggtcat ccggtgtcgg cggccgtcgg cctggccaac ctcgacatct 247681 tcgagcgcga gggtctcagc gatcacgtca agcggaattc ccccgcgctg cgggccaccc 247741 tggagaaact gtacgacctg cccatcgtcg gcgacatccg cggcgagggg tatttcttcg 247801 gcatcgaact ggtcaaagac caggcgacca agcaaacctt caccgatgac gaacgcgcac 247861 gactgctagg ccaggtatcc gcggcgctct ttgaggccgg gctgtactgc cgcaccgacg 247921 accgcgggga ccccgtcgtc caggtggctc ccccgctgat tagcggacag cccgagttcg 247981 acaccatcga aaccatcctg cgcagcgtgc tcaccgacac cggacgcaaa tatcttcatc 248041 tgtaactttc gtcccgccag tcacagcgcg gctcctcgcg gtcgggccgc cgatcaccta 248101 ctctgcacag acgatggcct tcttacgttc ggtatcgtgc ctggcagcag ccgtgtttgc 248161 ggtaggcacc ggaattggtc tacctaccgc ggccggcgaa cccaatgccg caccggcggc 248221 gtgcccgtac aaggtgtcca ccccacccgc cgtggactcg tcggaggttc ccgcggccgg 248281 tgaaccccca ctgccgctgg tggtaccccc caccccggtc ggcggcaacg cgctgggcgg 248341 ctgcggcatc atcaccgccc ctggcagcgc gccagcgccc ggcgacgtct cagccgaggc 248401 ctggctggtg gcggacctgg acagcggcgc ggtgatcgcc gcccgggatc cgcacggccg 248461 gcaccgcccg gccagcgtca tcaaggtgct ggtggcgatg gcgtccatca acacgctcac 248521 cctcaacaag tcggtcgccg gaaccgccga cgacgcggcg gtcgagggca ccaaagtcgg 248581 ggtgaacacc ggtggcacct acaccgtcaa ccagctgctg cacgggctgc tgatgcactc 248641 cggcaacgac gctgcgtacg cgctggccag gcagctcggc ggcatgccgg ccgcgctgga 248701 gaaaatcaat ctgctggccg ccaagctggg cggccgggac acccgagtgg ccacgccgtc 248761 cggactggac gggcccggca tgagcacgtc ggcctatgac atcggcctgt tctaccggta 248821 cgcgtggcag aacccggtct tcgccgacat cgtcgcgacc cgcaccttcg acttcccggg 248881 gcacggcgac catccaggct acgagttgga gaacgacaac cagctgctct acaactatcc 248941 gggcgcgctc ggcggcaaga ccggctatac cgacgacgcg gggcagacct tcgtgggcgc 249001 ggccaaccgc gacggccggc ggctgatgac ggtgctgctg cacgggaccc ggcagccgat 249061 cccgccgtgg gagcaggcgg cgcacctgct cgactacggg ttcaacaccc cggcaggcac 249121 ccagatcggg acactgatcg aacccgaccc gtcgctgatg tccaccgacc gcaatcccgc 249181 cgaccggcaa cgagtcgacc cccaggccgc ggcgcggata tcggccgccg acgcccttcc 249241 ggtgcgggtt ggcgtggccg tcatcggcgc cctgatcgtg ttcgggttga tcatggtcgc 249301 gcgggcgatg aaccgccggc cgcagcacta gctgcttacc ccgatacctt cggcgtcgtt 249361 tgcgggcggg catcctagcc ggccttggtc ggcaccgaaa tcggggcttg accagcggtt 249421 gaccgcgtga cgacgctgtg gcagcctcat cgaaatgact acagccctat accaggacgc 249481 ggggttcacg cccgccgggg cgcccgacga ccccgaccgc gtggtggacg tgctgagcgc 249541 cccggtaccg gtcaactgac cagatcgggg cgccgggcgc tcctcgtcgg gctcaccgcc 249601 gccagcgtcg gcgtcctcta cgggtacgac ctttccgcca tcgcgggtgc gttgctgtct 249661 ctcagcgagg aattcgaact caccactcga gaacaggagt tgctgaccac cacggcggtg 249721 ctcggccaga tcgccggggc gcttggcggc ggcatcctcg ccaacgcgat cggacgcaag 249781 aaatcggtgg tgctcatcgt cgccggctac gcagtgttcg ccctgctcgg cgcgacctcg 249841 gtgtccgtac cgatgctggt ggtggcgcgt ctgctgctgg gtgtgacaat cggcctgtcg 249901 gtggtggtgg tgccggtgta tgtggccgag tcggcgccgg cggcggtgcg tgggtcgttg 249961 gtgaccgcgt atcagctggc gacgcttagc ggcatcgtcg tcggttacct ggtcggctac 250021 ctgttggccg gatcgcacgg ctggcgcgcg atgttcgggc tggccgccgc gccggccacg 250081 ctgctgttgc cgttgttgtg gcgcatgccc gataccgccc gctggtatct gctcaagggc 250141 cggatcgccg acgcgcgtag cgcgctgcgg cggatccagc cggaggccga catcgatgcc 250201 gagctggccg atatggcggc cgcggtcgac gaacgcggcg gcggtatcgg cgaaatggtg 250261 cggcggccgt atctgcgggc cacgctgttc gtcatcgcgc tcggcttcct cgtccagatc 250321 accgggatca acgcgatcat ctactacagt ccgcgacttt tcgccgccat gggcttcgcg 250381 ggctatttcg cgatgcttgc cctgcccgcg atggtgcaag tcgccggctt ggcggcggtg 250441 tgtgcctcgc tgtttctggt cgatcggctg ggccgtcgcc cgatcctgtt gtccggcatc 250501 gcgacgatga tcaccgcaga tgccgtgctg atcaccgtat tcgccaacga ctccgatggt 250561 ggcacggggc tggtgttggg gttcgccggc gtgctgctgt tcatcatcgg gttcaacttc 250621 ggattcggct cgctggtctg ggtgtacgcc gcggagagct tcccgtcccg gctgcggtcg 250681 atgggatcga gcccgatgct cacctcgaca ctgacggcca acgcgatcgt tgccgccttc 250741 tcgctcacca tgctgcgtgt gctcggcggc gcaggcgttt tcgcggtctt cggcacgttc 250801 gccgtcgtcg cgttcgtggt cgtgtaccgc tttgcgccgg agaccaaggg ccgcaaactc 250861 gaggagatcc ggcacttctg ggagaacggc ggccgctggc ccgccgagcg gtcaccggcg 250921 gcggacgaac cgtgaccgtg ctcggcgccg acgccgtcgt catcgacggc cggatatgcc 250981 ggccagggtg ggtgcacacc gccgatggtc ggattctctc cggtggcgct ggggcaccgc 251041 ccatgccggc cgacgcggaa ttccccgatg cgatcgtggt gcccggcttt gtcgatatgc 251101 atgtgcacgg cgggggcggc gcgtcgttcg ccgacggcaa cgccgcagac atcgcccgtg 251161 cggccgagtt tcacctgcgg cacggcacca ctaccacgct ggccagtctg gtcaccgcgg 251221 gccccgccga gttgctctcc gccgtgggcg ctttggccga ggcaactcgg gacggcgtcg 251281 tcgcgggcat ccatctggag gggccgtggc tgagcccagc gcggtgcgga gcgcacgacc 251341 acacccggat gcgtgccccg gatcccgccg agatcgagtc ggtgctcgcc gccgccgacg 251401 gcgccgtccg gatggtcacg ttggcacccg agttgcccgg aagcgatgcg gcgatccggc 251461 gcttccgtga cgccgaagtg gttgtcgccg tggggcatac ggatgcgacc tacacacaga 251521 cccgacacgc catcgacctg ggcgcgacag tcggcaccca cctgttcaac gcgatgccgc 251581 cgctggacca tcgggcgccc ggacccgtgc tggcgttgct gtgcgacccg cgggtgaccg 251641 tcgaaatcat cgccgacggc gtgcacgtgc accccgcggt ggtgcacgcg gtgatcgaag 251701 ccgtcggtcc cgatcgggtc gccgtggtca ccgacgcgat cgccgcggcc ggatgcggcg 251761 atggcgcgtt ccggctcggc acaatgccga tcgaggtcga gtcgagcgtg gcacgggtgg 251821 ctggtgcgtc gacgctggcg ggcagcacca ccaccatgga tcagctcttc cggacggtgg 251881 ctgggctcgg ctcgaagtcg gactcagccg gcgatgtggc gctggccgcc gcggtgcagg 251941 tgacctcggc gacgccggcc cgcgctctcg ggctcaccgg ggtgggccgg ctggcggcgg 252001 gctatgccgc caatcttgtt gtgctggacc gtgatctgcg ggtgacggcc gtcatggtca 252061 acgatgactg gcgggtgggc tgagcgtccg tggaggcccg tcacaatgcc caggctcgca 252121 ccgtgagtac tcggtcaacg ttgacggttg ccccggcgac ccggtcactc tggcgagggc 252181 taccggcgcc gcgcggcttg taccgcaatc atccgatcgc cgcgaagcgc tcggcagccg 252241 gcttgggcgg tagccgacga cacgggtacg gtctcacggc gcgagcctga taaagcccgg 252301 cggcatgggt cgtgcaggcg acggctctac cggtccgtca ccaccgccgc caccaccgct 252361 gccggcgccg ccactgccgg cagcgccccc ggactgcgga acaccagcag gcggctcaac 252421 ctctggcggc gggggcggcg gctgttgcgg cggcgctggt cgcggtggcg gcggtgccac 252481 gatcggcggg ggtggaatca gggtctgcgc cgccggcggc ggtaccggaa tcggcggcgg 252541 attcggtatc aggggatccc ccgcgcgaac cgctccgagc accgaggcaa gcatcgcacc 252601 cgtcggttcc cgccatcccg gcgacatgat ggtcatgtcc gacaccgacg cccgcaggtc 252661 gcttcccgag ttgaccgcgc tgcgcgtgga cgccgcaacg cgatgcgtcg gttcattcga 252721 tcccggctcg aaattggcca tggcgaacgc catcttgctg tgatggttcg ggcagtagat 252781 ctccactgcc gcactgataa atcgggtcat ggtcgtcgtg aggcggacag ggtagaggcg 252841 catgaccggg tctatgttgt aggcatcgtt gcgtaacccg tccacaatgt cgttcaccgg 252901 catgccgcca tcgagtttgc gacacacttt gtgggccgcg tcgatgacgc gaggcacatt 252961 cgcgacggcg gggatttcct ttttctcgag cagcgccaga aaccgatcgt cttggtttgg 253021 gtcggccgct gctgggccgt cgtgcagaat tgcggcgccg atcagcacca ctaaggcggc 253081 acccagggcg ccggcatggc tagcgatgcc ggtgaacatg atggggtttc cgttctgcta 253141 aaagccgtta cctggcgggc tttggatcgc gatccacgcc ataggtgtgg ctgtctggtc 253201 aggtttgacc ggcgccatga tgtcgtttca cagcgccgat gcagtctggg aggggaccag 253261 ggcatgggtg cattgaggag ccagatccag agaaccacac cggagccgct ggccgaggct 253321 catccacaag ccttcgatcc cgctcccgtt gtcggcatgg gcgcctgccg acggaatcag 253381 cggatggtca tagtggcgtc gggcgccagg cctgcgcggg cacacgcggt gcggtgtcga 253441 tggttgttct catctggtaa ctcctttccg caggccgcaa ttcagcggta tgggctcacc 253501 gagatcaggc tcgtcacgat cgcccgcact gctggcggct cacatgtacc cagtgttaac 253561 cttctagtgc actagaaggt caaggggagt cgcatgaaga tcagcgaggt agccgcgctc 253621 accaacacca gcaccaagac cctccgcttc tacgagaact cggggctgct gccgccgcct 253681 gcacgcacag catcggggta tcgcaactat ggacccgaga tcgtggatcg gctgcggttt 253741 atccatcggg gccaagcggc cgggctggca ttacaggaag tacgccaaat cctggccatc 253801 cacgaccgcg gcgaggcgcc gtgcgcacac gtccgccaac tactgagcac ccgcatcgac 253861 gaagtccgcg cgcagatcgc cgaactgatt gccctcgaag gccacttgca gaccctgctt 253921 gaccacgctt catatggccc gcccaccgaa cacgaccact ccacggtgtg ttggatcctg 253981 gaaagcgacc tcgatgagcc caccgccatc gaggtcagcg acattcacgc ctagaggtcg 254041 ctgggtacgc gggctggccc acgggtttta cgccgaagcc gtcgccgccc acgcggtggc 254101 gaacaggatc agccacgcgg tgacgaacgc gaacaccatc aagcccagca ccggcccgaa 254161 caccgcgccc gccgggctgc gcaacactat ctgcaggtag atcgccccca cctgcttgaa 254221 cagctcgaag ccgaccgccg ccatcaaccc ggcccgcgcc gcggtgacca aaccgaccgg 254281 ctcccgcggc agccggccaa tcatccaggt gaacagcacc cacgacacca gcaccgatac 254341 cagcaccgag atgccccgaa agatctcgtc gaacactgaa aactggggta tttcaagcca 254401 tctcagtacc gcagccatcg gcctggcatg gccgagcacg gtgagcgcga tggtggccac 254461 gatcaccacg aacgtcccca ccatggccgc tagatccgac agtttggtgc gcaagtagcc 254521 cgccggagcg actggatgtg cccacatctg gctcaacgct tcccgcaggt gccacatcca 254581 gcccaggccc acccaggccg cggtcgccag accgatcacc ccgaccgacg cgcgtgcatc 254641 gatcgccgaa ttcatcaggt cgaccagctg ctgtcccacc gcaccggaga ccgaggtgcg 254701 gatgcgctcc tcgagcgtgg tcagcagctc cggacgacgc gacaacgcga atccacccac 254761 cccgaaaccg accatcagca aaggaaatat cgcaaagatc gtgtagtagg tgagtccggc 254821 cgcaaaaaga ctgccgttgc gatcgttaaa gcgcgtgaac gcacgcacga catggtccaa 254881 ccacccgaac cgggcccgca gccggtcaag cacccctggc tcggcgagct cgcccatgat 254941 cgactgccct acccccgtta tagaaggaac ccgagccgat cgtagactcg ctgaaccgtt 255001 ttgctggcca catcgtgggc gcgctgcgcc ccggcggcga gcacggcctc cagctccgcg 255061 ggatctgcgg tcaattcgtc aactctggct tggatcgggt tgacgaattc gacgacggcc 255121 tcggcggtgt ctttcttcaa atcgccgtag ccgtgtccgg catagccgtc gacgagaacg 255181 tcgatgtcgg tcccggtgac cgccgactgg atgttcaaca ggttagacac ccctggcttg 255241 acgtccgggt catagcggat gtcacgttcg ctgtcggtca cggcggagcg aatcttcttg 255301 gcggacaatg ccggatcgtc gagcaggttg atcaaaccgg catcggtgcc cgccgatttg 255361 ctcatctttg acgtcgggtc ttgtagatcg tagattttgg cggtcatctt ggggatgagc 255421 acgtcgggaa ccaccagggt gccggggaat cggctgttga accgttgcgc gacgtcgcgg 255481 gccagctcga ggtgctgccg ctgatcctcc ccgacgggca ccagctcggt gtcgtaggcc 255541 aacacgtccg cggcctgcag taccgggtag gtgaacaggc cgacggtggt ggcctcgctg 255601 ccctgacgcg ccgacttgtc tttgaactgg gtcatccgcg acgcctggcc aaagccggtg 255661 aaacaaccca gcacccacgc cagctgggtg tgagccggca cctgactttg cacgaagatg 255721 gtggcgcggc cgggatcgat tcccaacgcc aggtattgcg cggcggtaat cagggtccgg 255781 cgccgcagtg cctcgggatc ctgagggatg gtgatcgcat gcaggtcgac cacgcagaag 255841 aacgcatcgt ggtcatcctg caagccaacc cattgggcga cggcgcccaa ggcattaccg 255901 aggtgaagcg agtcagacgt gggctgcacg ccggagaaga tccggcggga cccggtaggg 255961 gtgctcatga tgccccgatc ctttcacgcg gggtgccctc cccgtcgacc accggtcacc 256021 acgctgcttg cggtaccggc ggtaccggct ttagtgtcgg ctctatgcgc agtccgatac 256081 gcgtgggttc gggagagccg gtcctactgc tacacccgtt cttgatgtcc caaacggtgt 256141 gggagaaggt cgcccagcag ctggccgaca ccggccgctt cgaggtattt gcccccacga 256201 tggccggcca caacggcgga ccggcctcgg gcacccggtt ttgtcctcgg cggtgctggc 256261 cgaccacgtc gaacgccagc tcgacgaact gggctgggaa accagccata tcgtcggcaa 256321 ctcgttgggc ggctgggtcg cgttcgaact cgaacgacgt ggccgggcac gcagcgtgac 256381 cggtatcgcc ccggcgggcg gttggacccg ctggagtccg gtcaagttcg aagtgatcgc 256441 taagttcatc gcaggggcgc cgatcttggc cgtcgcccac attcttggcc aacgggcgct 256501 tcggctgccg ttcagccgcc tgctggccac cctgccgatc agcgccacac cggacggcgt 256561 gagcgagcgc gagctgtccg gcatcatcga cgacgccgcg cactgcccgg cctattttca 256621 gctgctggtc aaggcgctgg tgctgcccgg gctgcaggag ttggaacaca ccgccgtgcc 256681 ctcgcacgtg gtgctgtgcg agcaggaccg ggtggtccct cccagcaggt tcagccgtca 256741 tttcaccgac tcactgccgg cgggccaccg gctcaccgtg ctcgacggcg tcggtcacgt 256801 tccgatgttc gaggctccgg ggcgcatcac tgagctgatc accagcttca tcgaagagtg 256861 ctgcccgcat gtccgggcca gttagcgggc gcgagcagac gcaaaatcgc ccatttcggc 256921 acgaaattgg gcgattttgc gtctgctcgc cctaattggc cagctccttt tccaggttgt 256981 cggcgatcgc atcgaggaat tcctcgctat tcagccagtc ctgctccgga ccgatgagga 257041 tcgcgaggtc cttggtcatc ttcccgctct ccaccgtggc gatgacgacg gactccagct 257101 tgtgggcgaa gtcgatgact tcgggagtgc catccagctt gccgcgatgc tgtaatccgc 257161 gggtccaggc aaagatcgac gcgatcgggt ttgttgaggt cggtttaccg gcctgatact 257221 gccggtaatg ccgggtgacg gtgccgtggg cggcttcggc ctcgactgtc ttgccgtcgg 257281 ccgtcatcag caccgacgtc atcaggccca gcgagccgta gccctgtgcg acggtgtccg 257341 actgcacgtc gccgtcgtag ttcttgcacg cccagacgta accgccttcc catttcaggc 257401 aggcggcgac catgtcgtcg atcaaccgat gctcgtaggt cagccccgcc gcttcgaact 257461 gcgccttgaa ttcctcttcg tagacgcgct cgaactcgtc tttgaacatc ccgtcgtagg 257521 ccttgaggat ggtgttcttg gtggacagat ataccggcca tttcgcgttg aggccgtagg 257581 agaacgacgc gcgcgcgaaa tcccggatgg attccttgaa gttgtacatc cccagcacga 257641 cgccgccgtc ctcggggatg gacaccattt cgtgcacgat cggcgcgctg ccgtcggcgg 257701 gcgtgaaagt cagtgtgacg gtgcccggtt ggtcgacctt gaagttcgtc gcccgatatt 257761 ggtcaccaaa agcgtgccgg ccgatgacga tcggcttggt ccaccccgga accagtcgcg 257821 gcacattaga aatcacgata ggttcgcgaa agattgtgcc gcccaagatg ttccggattg 257881 tcccattggg cgacagccac atcttcttca ggttgaattc ctcgacacgg gcctcgtcgg 257941 gggtgatcgt cgcgcacttt acgcccacac cgtgtttctt gatcgcatac gccgcgtcga 258001 tcgtcacctg gtcgtcggtg gcgtcgcggt gctcgatgcc caagtcgtaa tagtccaagc 258061 ggatgtcgag atagggaagg ataagcatgt ccttgatgag cttccagatg acacgggtca 258121 tctcgtcacc gtcgagctct acgaccggac cgctgacttt tatcttgggt gcgttggaca 258181 tgggagtcca catcagatta ctagcagccc gcgcgggccc ctagcggccg gtaaagggcc 258241 agttgagacc gccggagttg tgctttgagt tggcactgag tagctgccat gcgctaggct 258301 tcgagtcggt catgagcgcc agcgtcaagc cccggcttgc tggccggcaa ccctccaacc 258361 gcggtggggt gccccgggtg atgaccaggt tgagtagcca tcgccggctg cgcggcaagc 258421 gcgggtccgc catgacgggc ccctgaccag acggggaaag ctcatgagcg ccgacagcaa 258481 tagcaccgac gccgatccga ccgcgcattg gtcgttcgaa accaaacaga tacacgctgg 258541 tcagcaccct gatccgacca ccaacgcccg ggctctgccg atctatgcga ccacgtcgta 258601 caccttcgac gacaccgcgc acgccgccgc cctgttcgga ctggaaattc cgggcaatat 258661 ctacacccgg atcggcaacc ccaccaccga cgtcgtcgag cagcgcatcg ccgcgctcga 258721 gggcggtgtg gccgcgctgt tcctgtcgtc ggggcaggcc gcggagacgt tcgccatctt 258781 gaacctggcc ggcgcgggcg atcacatcgt gtccagcccg cgcctgtacg gcggcaccta 258841 caacctgttc cactattcgc tggccaagct cggcatcgag gtcagcttcg tcgacgatcc 258901 ggacgatctg gacacctggc aggcggcggt acggcccaac accaaggcgt tcttcgccga 258961 gaccatctcc aacccgcaga tcgacctgct ggacaccccg gcggtttccg aggtcgccca 259021 tcgcaacggg gtgccgttga tcgtcgacaa caccatcgcc acgccatacc tgatccaacc 259081 gttggcccag ggcgccgaca tcgtcgtgca ttcggccacc aagtacctgg gcgggcacgg 259141 tgccgccatc gcgggtgtga tcgtcgacgg cggcaacttc gattggaccc agggccgctt 259201 ccccggcttc accacccccg accccagcta ccacggcgtg gtgttcgccg agctgggtcc 259261 accggcgttt gcgctcaaag ctcgagtgca gctgctccgt gactacggct cggcggcttc 259321 gccgttcaac gcgttcttgg tggcgcaggg tctggaaacg ctgagcctgc ggatcgagcg 259381 gcacgtcgcc aacgcgcagc gcgtcgccga gttcctggcc gcccgcgacg acgtgctttc 259441 ggtcaactat gcggggctgc cctcctcgcc ctggcatgag cgggccaaga ggctggcgcc 259501 caagggaacc ggggccgtgc tgtccttcga gttggccggc ggcatcgagg ccggcaaggc 259561 attcgtgaac gcgttgaagc tgcacagcca cgtcgccaac atcggtgacg tgcgctcgct 259621 ggtgatccac ccggcatcga ccactcatgc ccagctgagc ccggccgagc agctggcgac 259681 cggggtcagc ccgggcctgg tgcgtttggc tgtgggcatc gaaggtatcg acgatatcct 259741 ggccgacctg gagcttggct ttgccgcggc ccgcagattc agcgccgacc cgcagtccgt 259801 ggcggcgttc tgaggaattc tgacatgacg atctccgatg tacccaccca gacgctgccc 259861 gccgaaggcg aaatcggcct gatagacgtc ggctcgctgc aactggaaag cggggcggtg 259921 atcgacgatg tctgtatcgc cgtgcaacgc tggggcaaat tgtcgcccgc acgggacaac 259981 gtggtggtgg tcttgcacgc gctcaccggc gactcgcaca tcactggacc cgccggaccc 260041 ggccacccca cccccggctg gtgggacggg gtggccgggc cgggtgcgcc gattgacacc 260101 acccgctggt gcgcggtagc taccaatgtg ctcggcggct gccgcggctc caccgggccc 260161 agctcgcttg cccgcgacgg aaagccttgg ggctcaagat ttccgctgat ctcgatacgt 260221 gaccaggtgc aggcggacgt cgcggcgctg gccgcgctgg gcatcaccga ggtcgccgcc 260281 gtcgtcggcg gctccatggg cggcgcccgg gccctggaat gggtggtcgg ctacccggat 260341 cgggtccgag ccggattgct gctggcggtc ggtgcgcgtg ccaccgcaga ccagatcggc 260401 acgcagacaa cgcaaatcgc ggccatcaaa gccgacccgg actggcagag cggcgactac 260461 cacgagacgg ggagggcacc agacgccggg ctgcgactcg cccgccgctt cgcgcacctc 260521 acctaccgcg gcgagatcga gctcgacacc cggttcgcca accacaacca gggcaacgag 260581 gatccgacgg ccggcgggcg ctacgcggtg caaagttatc tggaacacca aggagacaaa 260641 ctgttatccc ggttcgacgc cggcagctac gtgattctca ccgaggcgct caacagccac 260701 gacgtcggcc gcggccgcgg cggggtctcc gcggctctgc gcgcctgccc ggtgccggtg 260761 gtggtgggcg gcatcacctc cgaccggctc tacccgctgc gcctgcagca ggagctggcc 260821 gacctgctgc cgggctgcgc cgggctgcga gtcgtcgagt cggtctacgg acacgacggc 260881 ttcctggtgg aaaccgaggc cgtgggcgaa ttgatccgcc agacactggg attggctgat 260941 cgtgaaggcg cgtgtcggcg gtgacgtgct cccgacgcga catgtccctg tcgtttggct 261001 ccgcggtcgg cgcctacgag cgcgggcgcc cctcgtatcc accggaagcc atcgactggc 261061 tgctgccggc cgccgcccgc cgcgtgctcg acctgggagc gggcaccggc aagctgacca 261121 cccggctagt cgagcgcggc ctggacgtgg ttgccgtcga cccgatcccg gagatgctgg 261181 acgtgctgcg tgctgcgctg ccgcaaaccg tcgcgctgct gggcaccgcc gaagagattc 261241 cgttggacga caacagcgtt gacgcggtgt tggtggctca ggcgtggcac tgggtggatc 261301 ccgcccgggc gattccggag gtcgcccggg tgttgcgtcc gggcgggcgg ctcggcctgg 261361 tgtggaacac ccgcgacgaa cggctgggct gggtgcgcga gctgggtgag atcatcggtc 261421 gcgacggcga tccggtgcgc gacagggtga cgctgcccga gccgttcact acggtgcagc 261481 gccatcaggt cgagtggacg aattacctga caccacaagc ccttatcgac ctggtggctt 261541 cgcgcagcta ttgcatcacc tcaccggcgc aggtccgcac caaaacgctc gaccgggtgc 261601 ggcagttgct ggccacccat ccggcgctgg cgaatagcaa cggcctggcg ctgccctacg 261661 tcacggtctg tgtgcgggcg actctggcct gacgccgcct ttagggcccg gtgccggtgt 261721 aaatcaggcc cgccagttgc tggccgacgt tgccgaagcc ggagaccagg gccgaggtga 261781 tcaggcccag cgcgccggtg ttgtacacac ccgagatgtc cgcgccgcgg ttgaggatgc 261841 cggagagttg ggtgccgaag ttggcgaagc ccgacgccga tccgagcagc ggatccgaga 261901 tcgcgttgag cacgcccgac atgcccgcgc cgaggttgtg gaagcccgac aacccgccgc 261961 caccgccgat gttgaagaac cccgacgacg ggaccgcggt ggtgttgccg aatcccggga 262021 cgggcgggat gaccaacccg gcgttgatgg ggccgagcag cgcgttgacg tcgagaacca 262081 ctgggattcg gtcgatggtg atctccagag ggaaggcgaa ggcgggggtg gcgccggaca 262141 acgcgaggcc cagcgggagt tggggaatgg tgatttccgg gctcacgaag ggtccgatgg 262201 tgacggacag gggcagctcg acatggattg gatcgacggg tatgtggaat cccgggatgg 262261 tgatttccgg tgttagatgg gtcacgccaa gcgaactcag cagcacggtg aatggcagaa 262321 tctcgctggg cgccgtttgg atggcgggga cattaacgtt gatgaacccc agcagcgtaa 262381 ggctgaatgg atcgatgatg gagcctgagc tgaatatcgg gcccacggtg acaccggttg 262441 cggggtcgag tcccagggcg ggaatcgtga tgtcctggac ggtgatgggg ccgaggtcga 262501 agactgggtc gatgcgaacc gtgatcgggg aaatggacac cggcgggatg gtgaagccgc 262561 cgatgtggcc ggttgcgctg aggtccaagg gaattgccgg aaattggatc gacggaacga 262621 tgatgggtcc ggcgccgccg gacgcgtgga tgttcgcgac agtgaattcg ggaatgatgg 262681 tgctggtgta ggagaagccg agcaggccct ggtagtcgcc ccgccagaag gcgccgttgc 262741 tgtagttgcc ggagatgaag gcgccggtgt tgacgtcgcc ggagttggcc accccggtgt 262801 tgatgtcacc ggtgttcaac caacccgtgt tgacactgcc cgggttgaaa ccgcccgtat 262861 tggcctgccc cgcgttgaaa ctgccggtgt tgtagctacc cgcattgacc acacccgtgt 262921 tgaacccacc cgcgttgaac aaccccgtgc tggcaatccc cgaattaccg atcccggtgt 262981 tataactccc cgaattgaac accccccagt tcccggtgcc agagttaaag aaccccacat 263041 taccggtccc cgaattaaac aaccccacat tcccgctgcc ggtattgaaa ccaccgaacc 263101 cggtcagatt atcaccggtc aacccaatac cgaaattccc actgccggtg ttagcgaacc 263161 caatattgcc cacacccata ttcgccaaac cgaaattgta gctgccggca ttaccaaacc 263221 cgatattacc caaacccatc agacccggcg ttaaccccga attcccgagc ccaaagttgc 263281 cccacccgac attgcccaac ccgacattgt tgccgccgat attgccgcca cccacattga 263341 acccaccgac gttgcccgca cccaggttaa agtccccgac attgcccaac ccgacattgc 263401 ccaaccccac atcggccaac ccgaaattga ggaccagacc ctgatgcagc gccgtcccgc 263461 tcgccaacaa tcccgacaac tgctgaccga cactacccaa acccgacacc aacgccggcg 263521 cacccaaccc caacacgctg gtgttgaaca gccccgacat gccagagccg aaattcagca 263581 cacccgaatg cagcgtgccg gcgttgaaaa cacccgaacc cccacccagc aacgccgacg 263641 gagcctgatt ccagccaccc gacaccatcg cgccgacatt cccaaacccc gacaccccac 263701 ccgcaccgga gttgaagaaa cccgacgacg gagcaccggt cgtattcccg aaccccggca 263761 cggcgggaag gtcgatgagg atgtgaacgg ggccgagcgt gctgtgggcc acgaggtcaa 263821 aggggatttc gccgatggtg attgccggaa tggtgacggc gccggtgcca ccggacaggt 263881 tgatgctcag cgggttcatc gcggggatcg tgaggccgcc cgggaagatg tcgacgggct 263941 cgctgtggcc ggtaatgctg gccagcagcg ggatctcgtc aatggtgacg acgggggtgc 264001 tgaacggcag gttggccagg aaagccgtga tggtcccttg cgacgagcta gcaccgatga 264061 ctatctggct taacgccagg ggggtaaggc cgatgggggt gttgaagagt cccgtaatcg 264121 gaccgatttt caggggcccg ccgggttgtg agccaaacaa gtaattcagc gtgacgggca 264181 cccgtggaat atcgaggtgc gggacggtga tggggccgag gccgacgctg accgtggtgg 264241 cggccaggtc gatctgggga atcgggatgc tcggcacagt gaagctgtcg atggcgacgt 264301 tggcgctgaa ctcggggcgg atcgcgggaa tgtcgatggc ggggataacg acggagccca 264361 gtccgccggt gagggtgagg tccaggaacg gcgtttgggg aagcacggcg gggcggtagg 264421 agaagccgag caggccctgg tagtcgcccc gccagaaggc gccgttgctg tagttaccgg 264481 agatgaaggc gccggtgttg acgtcgccgg agttggccac cccggtgttg atgtcaccgg 264541 tgttcaacca acccgtgttg acactgcccg ggttgaaacc gcccgtattg gcctgccccg 264601 cgttgaaact gccggtgttg tagctacccg cattgaccac acccgtgttg aacccacccg 264661 cgttgaacaa ccccgtgctg gcaatccccg aattaccgat cccggtatta taactccccg 264721 aattgaacac cccccagttc ccggtgccag agttaaagaa ccccacatta ccggtccccg 264781 aattaaacaa ccccacattc ccgctgccgg tattgaaacc accgaacccg gtcagattat 264841 caccggtcaa cccaataccg aaattcccac tgccggtgtt agcgaaccca atattgccca 264901 cacccatatt cgccaaaccg aaattgtagc tgccggcatt accaaacccg atattaccca 264961 aacccatcag acccggcgtt aaccccgaat tcgccaaccc gacattgcca aacccgacat 265021 tgcccaaccc gacattgttg ccgccgatat tgccgccacc cacattgaac ccaccgacgt 265081 tgcccgcacc caggttaaag tccccgacat tgcccaaccc gacattgccg ccaccgaggt 265141 tgctcaaccc cacgttcggg ccgacgatcc cgaccgcgga attgaagccc gagatcaggt 265201 tgttggcgat gctcccgtcg aacaggccca acagtcccac acccaggccc gggacagcca 265261 aaccgctgaa gggatccgac gtggtggtgg tggagttccc tgagcccggc tcggtgatga 265321 tcgggatgtt gatggggccc accgggattg tgacgtccac gttcagcgga attgcgggca 265381 gcacggtggc cgggatgaag acggcgtcct cgaggttgat ggacacgtcg ataggcagga 265441 tttcgtgcag aatcattgac tttacggtgg atgccgggga accgaaagag aagttgagcg 265501 gtatggattc actgacagtg ggcaacggga tactgagtcc cgccatggtg atgggaatag 265561 aacttcccgg aattacaatc ggattcagtt cgatgccgtc tctgaagtca aacaagaaaa 265621 gagtctgacc gaccgacatg aacagctggg cgggctgggt ctgtatattc gtgatttgga 265681 ttccggagat atcgatgctt cccgtgatgc ccaggccgga cagcagggta gtggccgggg 265741 cgttaaaact cacattgacg tttccgtcga ggccaaaatt gatggcgggg atggggatgt 265801 ccgggacggt aaaggggccg acctcgaggt ttcccgtgac ggtcaggagg ggatttagcg 265861 catccacaac ggtggtggtc gggatgctga tggggccgat gccgccgttg agggtgaagt 265921 gaaatggaaa cagcccgctg gtgaggccaa agccgcctgg gaccgccgga atggggccgt 265981 tggccggggt tggcgggatg tagtcccacc ggaacgggaa agggccaata gaaagggtgg 266041 tgtgcaggtc caccgggatg cggtcaaccg tgaaaccctg cgggaacacg gtgaatccac 266101 cggtgccgac ggagaagttg gtgaggctga ccacggggtt ttccgggaac gccaggccgc 266161 ccgggaatag cgtgatgctg tccaggccgc cggtcaggtt gacggtcacc ggtgtttggt 266221 cgggaacggt gaggccggcc gggaacaagg ccaaggacga tgtggacaga ttgaaagtcg 266281 cgccgaacgg gccggggatc gtgcccgggc cgccgtagct gccgatgatg ggtccattga 266341 tctgcaggtc gctgatgctg aggtagaacg acccggaggg gaatttcgcg ccgggtgggc 266401 ctagcggcgg gccgtagtgg tcgatcgtga tgaacgggtc cggcaagacg accgggtccg 266461 cggtgatttc tgccatggcg gtttgcccga aaagaacaaa cgcgggattc acgtgaaaac 266521 cctcgaggcc gacggttccg gtcacgtgga tcgggatcgc gggaatggtg atctccggga 266581 gagtgaattc gcggatcccg atgaatcccc cggtgatttg tatgtcgaat gccggaatat 266641 cgatgggctg gacgtggatg ggaccgatcc cgccaatcac ctgcaggtca atggggattt 266701 cggaaatggt gaaaagggtg ccgggggtga agggggccag gacgttgatg ttgttgcccg 266761 ttaagaagaa accggtgttg tggcttcccg aattgaatac gcccaaattc ccggtgccgg 266821 agttgaagaa cccgacattg ccggtacccg aattgaacaa tcccacattc tcgctgcccg 266881 aattgaaacc accgaaccca gtcagattgt ccccgctgag cccgataccg atattcccgt 266941 tgccggtatt ggccaacccg atgttgccga tgcccatgtt cgccaggccg aaattgctgc 267001 tgccggcatt gccgaacccg acgttgtcga acccgatatt gcccaatccg aagttgttgc 267061 cgcccagcgc gccgcccgac aacatccccg acaactgagt acctacattg ccgatacccg 267121 acatcaacgt gccggagttg aaatagcccg aaaccgttcc cggcaacacc tgcatggcct 267181 gggtggactg gttaaaccag cccgaggtgt gcgcgccgac gttcccgaat cccgacaccc 267241 cgccggcgcc ggtgttaaag aagcccgagg acggggcggt ggtcgaattc ccgaaccccg 267301 gcgacgccgg aacgttgccg cccacgatgt cgacgggccc gacgccgccg atggcgtgca 267361 ggttcagggg gatgttgtcg atggtgattg ccggggtgct cagggcgttg atgtggccaa 267421 tcacgttgat cgccagcgga agtggttgct cgggaatcga gaatcccgga atggtgaagg 267481 cctcggtgcc tgccgttacg ccaagagtca gggtgagcgg ccccccggtg ggaatgctga 267541 ggccaaccgg gaaaagggtg agggctgggg tggaataact gaaggttact gggatggaaa 267601 acccggtatt gatatgtatt gggccgatca aggttgtggg aatgggggaa gggctgaggg 267661 cgacctgttg gatttgggga attgttatgg acgagacggg ccaggccagc gtgatggttt 267721 ggttgaagtt ttgtgccggc cacagggtga tgggattgat tttgatgggg ccgatcgaaa 267781 tattgggtat gccgacgccg agcgagattg ccgggacgtt gatgggcggg acgaccaagg 267841 gtccgaggta gagggtttcg ttgatgttga tcgggatgtc gggaagtatg tggatgggct 267901 cgatagtgat ggcgccgaca ccaccgttta tgtccaggct gaggggaatg acaggaagaa 267961 cgttcgctcc cgaggagaag ccgagcaggc cctggtagtc gccccgccac aagacgccgt 268021 tgctgtagtt accggagatg aaggcaccgg tgttgacgtc gccggagttg gccaccccgg 268081 tgttgatgtc accggtgttc aaccaacccg tgttgacact gcccgggttg aaaccgcccg 268141 tattggcctc ccccgcgttg aaactgccgg tgttgtagct acccgcattg accacacccg 268201 tattgaaccc acccgcgttg aacaaccccg tgctggcaat ccccgaatta ccgatcccgg 268261 tgttatagct ccccgaattg aacacccccc agttcccggt gccggagtta aagaacccca 268321 cattaccggt ccccgaatta aacaacccca cattcccgct accggtattg aaaccaccga 268381 acccggtcag attatcaccg gtcaacccaa taccgaaatt cccactgccg gtgttagcga 268441 acccaatatt gcccacaccc atattcgcca aaccgaaatt gtagctgccg gcattaccaa 268501 acccgatatt acccagaccc atcagacccg gcgttaaccc cgaattcccg agcccaaagt 268561 tgccccaccc gacattgccc aacccgacat tgttgccacc gatattgccg ccgcccacgt 268621 tgtagctccc gacgttgccg gcccccacgt tgtagctgcc gacgttgccg cttcccgcgt 268681 tgaagaggcc aacgttggcc aaacccagat tgacggcgag cgacttggcc ggctcggcgg 268741 cggccgccag gcttgccagc ggcgagccaa acggcgccaa cgcctcggcc gccgccgagg 268801 cgccggtgtg gtaccccagc atcgcggcca cgtcctgggc ccacatcagc tcgtagtcga 268861 actccgcggc cgcgatcgcc ggcgtgttct ggccgaacag attcgataac gccagcgaca 268921 ctaacctcga ccgattggcc gcgatgacga aggggtccac cgtctcggcc aacgccgcct 268981 cgaacacacc caccaccgcc cgggcctgcc cggccgccga ctcggcggag gccgccgccg 269041 cgctcaacca ccccgcatac ggggcggccg ccgccgccat cgcgaccgag gacggcccct 269101 gccagatacc accgaccagc cccgaggtca ccgacccgaa agccgccgcc gccgagccca 269161 gctcggcggc cagctcatcc caggccgcgg ccgccgccaa cagggggccc ggacccgccc 269221 cggtatatat cagcagggag ttgatctctg gcggcattac gacaaaactc atgccgccag 269281 ccctttcccg tgcgttccca acatcgctgt caaccggtga tcagggtgtt gcgccggcgc 269341 cgccgaggcc gccgtcgccg ccgaaccctg gctccgtgcc tgagttgggc tggccggcct 269401 gccctttgcc gccggcgccg ccggccttgg cgccgctgtt gccgccgttg ccgccgtcac 269461 cgccgtcacc gccgtcaccg ccgaggccgg tcgcgctctg agtgccgccg ccaatgccgc 269521 cctggccacc cttaccgccg ttgccaccga agccgccgtc cggggcgttg cctccgccac 269581 cgcccgcgcc gccaaggccg ccgttgccgc cggtggagcc gccgccattg ccgccctgcc 269641 caccgaggcc gccctggccg ccggcaccgg caaagacgcc gtcgccgccc cggccgccga 269701 caccgccgtt gccgccgcca ccggccacgg tgccgacggt accgccgccg ttggggccgc 269761 cctgaccgcc gtcgccgccg aagccgccct tgccgccgaa aaagccgctg ccgccggcgc 269821 cgccggcgcc gccgccaccg ccgctgccgc cttgggtgac ggagctgttg ccgccgacgc 269881 cgtcaccgcc gtggccaccg tcgccgccct tgccgccctc gccggagcta aggctgccgt 269941 ttccgccggc gccgccagcg ccaccggccc caccggaacc gccgacgatg ccgctgttgg 270001 cgccgatcga gcccccgttg ccgccggcac cgccgttgcc gcccttgccg ccgtcgccac 270061 ctgagccgtt ggggttgctg ccaccggcgc cgcccttgcc gccgttgccg ccgggggcgc 270121 ccgtgacccc gatggaggcg gggccgctgg tagcgccgaa gctcccatca ccgccattgc 270181 caccggcgcc gcccttgccg cctgagccgg tggcgttacc cccggcgcca ccgttgccgc 270241 cggagccgcc ggcgccgccg cggctgccgc tgcccgggtt ggtggcaggc ccaccgtggt 270301 caccgttgcc cccgtcgccg cccttgccgc caagcacgac gccggtgccg ccggcgccgc 270361 cgttgccgcc gttgccgccg gcgccgccgc caatgccgct gccgctgccc ccggtgccac 270421 cgaacccacc ctggccacct gcgccgccgg cgccgcccgt gtcgccgctg ccgccggcgc 270481 cgccgtggcc gccgttaccg gcgttgccac cgcgagcgtt gccgttgctg gaaccgccgt 270541 tggcgccagc gccgcccttg ccgcccgcgc cgccggtgga gccagggccg acaccgtcgc 270601 cgcccttgcc gccattgccg cctgagccgg cgttgccggc atcgccaccg ccaccgttgc 270661 cgccggcacc gccgttgcca ccggcaccac cggcgccgcc gttgccggcc gagccagcgc 270721 cgccgttgcc accggcacca ccgctgccgc cgtgggccgc cggactggcc tgtgctcagg 270781 ctgcccccgc cagcaccggc gccgccgttg ccgccggccg cgccggcgcc gcccgtggtg 270841 ccgctgccac cgctgccgcc gctgccgccg tggccggcgg cgctggaagt gccgccgccg 270901 ttgccgccgg cgccggcggc accaccggcc aagcccgcga cgccggtgct gttgccggag 270961 ttgccgccgt tgccgccgtt gccgccgtcg ccgccggtgg caccgccgcc gtggccgccg 271021 ttgccggcgc tgccgccggc accgccctgg ccgccggcgc ccgcggagcc gttgccgccg 271081 ttgccgccat tgccgccgtt gccgccgtgg ccggcggtga cgttgacgac gcctgagccg 271141 ctggcggcac cgctgctgcc gttgccgccc ttgccgccgg cgccgcccgt cgtgccgtcg 271201 ccgccgtggc cgccgttgcc gccgttgccg ccgtcgccgc ccacagcgtt gccgaaggac 271261 acgccggcga cacccgcgtt gccgccggcc ccgccagcac cgcccgcgcc gttgaggcca 271321 gtgcccccat taccgccggc accaccggag ccggcgttgc cggtggtcgt gcttttgctg 271381 ctaccgccgt taccgccagc gccaccggcc cctccggcac cgcccgcgtc ggtgccgata 271441 ccgccattgc cgcccgcgcc gccggagccg gcgtcaccgc ccaaaccgac gttcccgccg 271501 tcgccgccgt tgccgccctt gccgccggcg ccgccgtcgc cgcccgtggt gctgacgccg 271561 ccgttgccgc cggcgccgcc gttgccgccg aggccgccat tgccttcggg gcctcccgga 271621 ccgccgtagc cgccgttgcc gccggcgccg ccaaacccag tctcggagac gccgccgttg 271681 ccgccgaggc cgccgttgcc gcctaaggaa atgccgccac cgccgtcgcc gccgctaccg 271741 ccgttgccgc ctgtgcgccc ttccccgccg atgccgccct ggccgccgaa gccgccgacc 271801 ccgccggcac cgccgtcccc gccggcgccg ccgacaccgc caacaccgct agcaaagtcg 271861 cccgcgccgc cgggaccgcc ggcgccgcct gggccaccca acccggtgct agcgaagccg 271921 ccggcaccgc cattgccgcc agcgccgccc gttgtcgcgg cgacgtcaac ggcgccgcca 271981 ccgccggcgc cgccgaagcc gccgaggccg ccgttgatca tgccggcacc gccattgccg 272041 ccgttaccgc ctttgccgcc cgtgccgaag aagccggcct ggttcagcgc cccaccgccg 272101 ttgccgccgt tgccggcgtc accgccgttg aggccggagc cgccgttgcc gccgttgccg 272161 ccggccgcgc cgctcccgtt gccggcggtg ccgcccttgc cgccgttgcc gccattgccg 272221 ccgttaccgc cgttgggggt gatgccgtcg gtgccgtcca agcccgtcaa ggagccggtg 272281 ccggccttgc ctccggtgcc gccgacgccg gcgttgccgc cgttgccgcc gttgccgccg 272341 gtaccggggt ttcctacggt gccgccgccc ggcagcatgg ccccgctgtt taggccgttt 272401 tcgccggccc cgccgtcacc ggctttgccg ccatcgccgc cgttgccgcc gtcgccgccg 272461 gtgcccgtgg cgccgtcggt gtacccggcc gcctgcgcct tgccgcccgc gccgccattg 272521 ccgccggcgc cgccgtcgcc accgttacca ccgctaccgc cgttctcgcc gtttgcgccg 272581 ttagcattgg ggccggcgcc gtcggcgcct ctctcgccgg cgccgccgat gccaccctgg 272641 ccgccgttac cacccttacc accgttgccg ccgtggccgg ccagtgttcc gccggcgccg 272701 cccgccccgc cgttgccgcc agccccaccg tcggtgcccg aggtgccgga atcaccgctg 272761 gtagggcccg gcgtaccggc ttggccggcc gcgccgttgc cgccggcccc gccattgccg 272821 ccattgccga cattcccgcc gctgccgccc ttgccgccgt caccgccgtt gccgcccgcg 272881 acggtggggc tggcgccgtt gccgccgttg ccgccgtcac cgccgctggt gggtgcggtg 272941 ccatcggcgc cggtcgcacc cttcatggct ggaatggcgc ccttgccgcc ggccccaccc 273001 tggccggcaa cgcccacatt gccgccgttg ccgccggcac cgccgttgcc ggccttagcg 273061 aacgtggcga aggcgtcacc acccttgccg ccgatgccgc cgttgccgcc gttgccgccc 273121 tgtccgccat tcgcgccatt ggcggacgcg gagaagtctt ggccgttggc tccggcgccc 273181 ccgttgccgc ccttgccgcc gtccccgccc gtgccggccg ccgatccgcc gttgccgccg 273241 atgccgccgt tgccgccgtt gccgccgttg agggcaaggc cggtgccggc gacgccattt 273301 ccgccggcac cacccgcacc gccgttaccg accgacccgc catggccgcc gttaccaccg 273361 gcgccgccgt tttctcccgc gacggtgggg gtggcgccgg cacctccgtt gccaccgttg 273421 ccgccgctgg tgggcgcggt gccgttcgcc ccggccgaac cgttcagggc cgggttcgcg 273481 ctaacaccgc cggccccacc cttgccgcca acgcccactt caccgccgtt gccgccgtca 273541 ccgccggcac cctggttgac ggccaaggtc acatcaccgg cggcaccggc tccgccatca 273601 ccggccttgc cgccgtcacc gcccttgccg ccgttgccgc ccataccgcc atcggcaccg 273661 ggcgaaccca aggtggcggc gtcgaatccg tttccgccgg cgccgccgct accgccggca 273721 ccgcccttgc cgccgacgcc gccgtcgccg tgctgggcgc cgccatttcc gccattaccg 273781 ccgtggcccc cggcgccgcc attggtgccg ttaccgcccg tcggttgtaa ggcggtaccg 273841 gtagcgccgg tggaacccgc atgaccggca ccgccggcgc cgccggtgcc gccgttgccg 273901 accaacccgc catgaccgcc attaccgccg gccccgccgg cttgtagggg tgagttggcg 273961 gtggcgccga tgccgccatc gccgccgttg ccgccgctgg tgggggtggc gccggcggca 274021 ccgtgcgcac ccgccagcag gccgccggcc ccaccggccc cgcccacgcc ggggttgccg 274081 ccgtgaccgc cgttaccgcc ggcaccgttg ttgacggcga aactcggatc gccagcgccg 274141 cccttaccac cgtcgccgcc gacgccgccg gccccgccgg ccccgccgtt gccaaccaat 274201 aacccgccgc gcccgccgtt gccgccggtt ccgccgttgc cgccgtcgct gccgtcgccg 274261 ccgttgaggc cggcggcacc cggcaggccc gcggccccgg cccccccggc gccgccgttc 274321 ccgaacagcc cggcgtcgcc accgttgccg cctatacctc cgatgccgcc gatcccgccg 274381 gcgccgccgt tgccgtagac aaatccgccg gacccgccga cgccaccatt ggtgccggcg 274441 ccgccggacc cgccggcccc gaacaaccag gcgttgccgc cggcaccacc gttagcgccg 274501 gtcccgccgg ccccgccggc cccgccgttg ccgttcaacc acccgccgga tccgccgaca 274561 ccgccggcag cgccggcccc gccggacccg ccggacccgc cgttgccgaa caacccggcc 274621 gcgccgccgg gcccaccgac ttgaccggcc gcccccgaac cgccgttacc gccattaccc 274681 cacaacaacc ccccggcccc accgggctgc ccggtccccg gcgccccgtg aacgccatca 274741 ccgatcagcg ggcgccccaa ccacagctgt gtgggcgcgt tgatcgcacc caacacttgc 274801 tgctccagcg cctgcagcgg tgatgcattc gccgcctcgg cagtcgcata cgcgctgcca 274861 gccgcggtca gcgagcgcac aaactgctca tgaaacgtcg ccacccgggc gctcaacgcc 274921 tggtactcct gcgcgtgggt accaaacaac gccgcgatcg ccgccgacac ctcatcaccg 274981 gcggccgcca acacctgcgt cgtcgggccc gctgccgccg cattcgccgc gctgatggcc 275041 tgcccaatcc cggtcaagtc cgccgcggcc gccgccacca gctccggcgc caccatcagc 275101 gacatgacca ttcctccaac accaatggcg cgtacagccg gctcgcgcga gccttgaccg 275161 ccggcggcaa cccgagcgat cccatggccc taggcggttc tcgggcgaac gccacgttta 275221 gcggatcgat tcacccggtc gttgcgttgc ggcgcagcaa tagacatctc gaagcactcc 275281 ggctgccaat ctcgtcgcgt ttattctgct cgtgaccagc gcaggaaagg gggggattac 275341 gaaagtcttc gggatctcag tgcacagtgc acacatgttt aaccaatcac cgtggcataa 275401 cgcacaccaa aggccgagag cgcggaaaac gcagaacatc aattggatcg gttgctagct 275461 ttgccgcacc gtggtcagcc gcgccaggat cggtcggcaa tggcaccacc ggagcaggcg 275521 aaaggtaccc ggttctagcc cgtccccaac gggtcaatgg tggatgcgat atagaccatg 275581 gccgccgcga ccgtcacggt cgtcacgaaa tcgatcccct tgctgcgcac caccaacagg 275641 ccggcccgtt cctcggacaa caccaaccgc agcaccgccg ccaccccaac gccgataccg 275701 atcagcagcg caccacggcg ccagaagttg acccccgcca ggatcggcca ctgggcgcca 275761 acagtgcgcc gcaaaacggc cctcacggtc atcgccgctc agccagctcc acgacacttg 275821 tcagcaagga cgcccggggc gaagggcgtt cgccaagtct gtagatgagc tgcgggagat 275881 ggccgacggc gagggttgag aagcgtcaac ttcgatcgtg atgcctggga ggacttctta 275941 tttcatacgc gatcggtgat gccgccctga agccgaggtc gacggcagcg cggagacgtt 276001 cgagaagacg tcgcggtgag gtcaatcccg gtgtgaccaa cggccggtta cggcccggtg 276061 cccgcgaaca gcaggcccga cagctgctgg ccgacgttca taaagcccga gacgaaggcc 276121 gatgtgacca ggccaagcgt gcccgtgttg tacacgcccg agatgcccgc gccacggttg 276181 aggatgccgg agagctgggt gccgaaattg gcgaagcccg acgccgaccc gagcagcgga 276241 tccgagatcg cgttgagcac ccccgacatg cccgacccgg agttggagaa gccggacccg 276301 ccaccaccgc cggtgttgaa gaagcccgac gacggcgcgg tggtgtcgtt gccaaagccc 276361 ggtgctccgc cgaacccgaa aatcgggagg ctgacggggc cgatggtggt gctggcgtgt 276421 aactccaccg ggatccggtc gataacgacc gtcgggagat caaagggtgg ggtgccgccg 276481 gacaaaccga ggcccagcgg gagttgggga atcagggtgc cgcccgggat ggtgaagccc 276541 ggaatggtca gcgacagcgg caggccgatg tggatgggtc cggtgggaat ggtgaatccg 276601 gggaagtgca gtgtcgtcgg gttcaagttg atgggtgcca cggtgaatgg ttgaagtatg 276661 gagacctcgc ccccgggcat gccgtcgggt ccgaccgcga agaatgaaaa gctgggtctg 276721 accttgaatc cggagctgct tccggacgtc atcctgatct ccgagacggc agcatccaaa 276781 cttaggccag ggatggtgag ggtgatgggg tccacggtga tagggccgac gtcgaaggtg 276841 ggatcgatgc ccaggtggat cgaggggatg gcgatgttcg ggatgctgat cggcccgatg 276901 tggccgatcg cggcgaagcc caacgggatg gacgggatgt ggatgggcgg aatgatggtg 276961 gcggggccga tgtcgccggt gacgtcggcg cccaccgcgg ggaacagcgg aatggggtac 277021 ccgaaggaga agccggccaa gccctcgtaa ttgccccgcc ataagatgcc gttgctaaag 277081 ttgcccgtga tgagggcgcc ggtgttgaca ttgcccgcgt tggcgacgcc ggtgttggcg 277141 ttaccggtgt tgaaccagcc ggtgttggtg ctgcctgggt tgaagccacc ggtgttggtg 277201 tcaccagcat tgaagctgcc cgtgttgtac gacccggcgt ttgccacacc ggtgttgaag 277261 ccgccggcgt tgaccaaccc ggtgctggcc accccggagt tgccgatacc ggtgttgtag 277321 ctgccggagt tgaacaaccc gaagttggca gtcccggagt tgaagaagcc gatattgcct 277381 gtgccggagt tgaacaggcc aatgttgcca gtgccggagt tcaagccgcc gatgccggac 277441 tggttgtcgc cggtgagccc gatcccgagg ttgttggtgc cggtgttgcc aaacccgatg 277501 ttgcccaggc ccatgttggc ccagccgacg ttgccgctgc cggcgttgcc cagcccgata 277561 ttgcccatgc cggccaggcc cgccgccaga cccgaattcc cgaacccgaa gttggcatcg 277621 ccgatattgc cgaacccgac gttgccgccg ccgatgttgc cgaagcccag gttcacgtcg 277681 ccaatgttgc cgaatcccag gttcacgtcg ccaatgttgg ccgcacccag gttgaggttg 277741 ccgatgttgc cgaggccgac gttgccgttg ccgacgttag ccaacccgat gttgacgatg 277801 gtgatggggt tttgccccac gttggaggcc aacaagcccg acaggtgatc accgacgttg 277861 cccaggcccg acaccaacgc cggcgtccca agcggcagcg tgctggtgtt gtagatcccc 277921 gacagccccg aaccgaggtt gagcacgccg gagtgcagtg tgccgacgtt ggcaataccc 277981 gaacccgcgc ctgccaaagc ggtgtgcgcc tggttccacc accccgacat gttcgcgccg 278041 aagttgccga aacccgagcc cccgcccgcc ccggtgttga agaagcccga cgacggaacg 278101 gtggtggtgt tcccaatgcc cggggtgggc gggatgttga tcagcgggat gtcgccggcg 278161 atgacgtaga gttcgccgtc ggcgttcgcc gggatctccg ggaacgtgat cgccggaatg 278221 gtggcgccgg gggtgccgac gaacacatcc aggttcagca gcgagttcgc cgggaacgtc 278281 agaccaccgg ggaacagggt gatcgcgtcg atgctgcccg gcacctggaa acccaacggg 278341 atctggtgaa tattgagcgc cggggtgttg aacgcctgag atgccgcatt gaagacggca 278401 tgcaccgggc cggtcgtgct gagcgtcggg attcccgaga tgatattgcc gccgacgaac 278461 aggtcaccgg cgttgtagat tctgccgacc gagtaccacg ttgggccgat cgcaccggat 278521 gacgtccaga cgataaacgg ctctatttcg ctggtcgccc cgaccgacgc ggccatatcg 278581 aggaccgctc gtgcggcggt cagggcggga atggtgaccg aggggaccgc gatggggccg 278641 aagccgacgc ttccggtgac gttcggattg agggcgggaa tatcgatttg cgggatggtg 278701 aaggcgccca tcgccgcgtt gccggtcagg tgcgcgttga tcgccagaac cgggatgggc 278761 gggacgacca ccgggccgaa ggccccggtg aaatgcgcgt ccaggatggt gatccgggga 278821 acgtcgaggc tgtaggaata gctgaatagg ccttcgtagt tgccccgcca caggatgccg 278881 ttgctgaagt tgcccgacat gagggcgccg gtgtcgacat tgcccgagtt cgcgatgccg 278941 gtgttggcgt taccggtgtt gaaccagccg gtgttgatgc tgcccgggtt gaagccaccg 279001 gtgttggtgt caccgacatt gaagctgccc gtgttgtacg acccggcgtt ggccagaccc 279061 gtagtgaaac caccggcatt gaaaagccca gtactgcccg ttccgctatt accgatgccg 279121 gtgttgaagc tgcccgagtt gaacaacccc cagtttccgg tcccggagtt gaagaacccg 279181 atgttgccgg tgccggagtt gaacaggcca atgttgccgg caccggagtt caagccgccg 279241 atgccggtct ggttgtcgcc ggtcagccca atcccgaggt tgttggtgcc ggtgttggcg 279301 aacccgatgt tgcccacacc catgttggcc aggccaacgt tggtgctgcc cgcattgccc 279361 aacccgatat tgccgatgcc gagcgccgcc cccaggcccg aattgccaaa cccgacgttg 279421 ccgtggccga tattgccgaa gccgacgttg gcgttcccga tattgcccaa ccctaggttg 279481 aggtcgccga ggttggccgc gcccaggttg aagtccccaa cgttgcccaa cccgaggttg 279541 tagttgccga catcggccaa cccgaggttg atgatggggc tttgggtcaa cgccgtcccg 279601 gccgccaaca cccccgacag ctgctggccc acgttgccgg cacccgacac cagcgccggc 279661 gtccccaaac ccacgatagc ggtgttgtac agccccgata tccccgagcc gacgttcagc 279721 acacccgagt tcagcgtgcc aacgttgaga acgcccgagc ccgcgcccgc caacgcggca 279781 tgcgcctggt tccaccagcc tgagctgccg gccccgaagt tgccgaaacc cgacaccccg 279841 cccgcgccgg agttgaagaa acccgacgac ggggtggcgg tcgcgttccc gaagccgggc 279901 gtcggcggaa cgatgatgat cggaacgctg ctgtccggca cgctgatgtt gagggccagg 279961 ctcagtggca gcggatcgat cgtgaaacca cccgggaata tcgtgatcgg atccagcacg 280021 ccggacgcat cgatggtcaa cgggatcgca ttttgcggga tgttgaggcc accggggaac 280081 agcgtgaagg ccggaagacc gcccgacaca tcgatcttga gcgggatagg cgatgtcgtg 280141 atcgttggga tggtgacggt tgggagggtt agtgcgaggc taccggtggt tgcgctgctg 280201 ggaccggtat ggatcaggat gccctgagtg ggtgcggtga caaagccacc actcattccg 280261 gttgagttgg acgccccaac gatccagttg tcgccgagcg cattcacgaa cagcaacgga 280321 agtctgaagg gcggcggggc gggggccggg ggcgtgtcga gcggaatcgt gtaggtctga 280381 ccgccgatcg tcatgctcgg caggaagacg atgggcggga tgaccatcgt ttcgtggatg 280441 tccagcacca ctgcggggac atcgatgggc tcgatcctga agggcccgat gttgacgagt 280501 tcgtggatgt cgaacagcga catgccggga atatcgatct gatcgatgtg gacgggaccg 280561 aggttgaggg tttcgttgat gtccaccagg gtgctgccgg tgatttcgat gctgtaggag 280621 aagccgacca gcccgtggtg atcaccggtc cacagcgcgc cgttgttgaa gctgccggag 280681 ttgaacgcgc cggtgttgac attgcccgtg ttgaagccgc cggtgttggt gtggccggcg 280741 ttgaaccagc cggtgttgac attgccaggg ttgaagccgc cggtgttggt gttgcccgcg 280801 ttgaggctgc cggtgttgta actaccggca ttggccagac ccgtgttgaa actcccggca 280861 ttgaaaagcc cggtactgcc cgttccgctg ttaccgatgc cggtgttgta gctgcccgag 280921 ttgaacaacc cccagtttcc ggtcccggtg ttgaagaacc cgatgttgcc ggtgccggag 280981 ttgaacaacc ccaggttgcc ggcaccggag ttcaggccgc cgaacccggt ctggttgtcg 281041 ccggtcagcc cgatcccgag gttgttggtg ccggtattgc cgaacccgat gttgcccagg 281101 cccatgttgc cgaagccgac gttgttgctg ccggcgttgc ccaacccgat gttgccgatc 281161 cccggcagcg cccccaggcc cgagttgccg aacccgacat tgccgtggcc gaggttgccg 281221 aacccgacgt tgccgtcccc gaggttgccc aaccccaggt tctgcccgcc gaggttgcca 281281 ccgccgaggt tgaggttgcc gaggttgccc gcgcccaggt tgacgtcgcc gacgttggcg 281341 aagccgaggt tgtagctgcc gacgttgccc aggttgacga tgttcagcgg attcaggtgc 281401 cgcagctcgg cgatcgccgc gtcgatgatg ctcggctgcc cggagccgcc cgacccgccg 281461 ctggtcagca tcgccagcag gccatcgatg gacacccccg acacgtggtt gcccaggttg 281521 ccgaaacccg agatcaccgc cggcgcggag cccagcgtgc tcacgttgaa catgcccgag 281581 atgtcgacgc cggagttcag cacaccggat gccaggctgc cggcattgcc caggccggag 281641 agcgtcccca ccatcggact cgaggcctgg ttcagcaagc cggacacccc cgcgccgaag 281701 ttggcgatgc ccgagccgcc accgccgccg gtgttgaaga agcccgacga cggcagctcg 281761 gtcgagttgc caaagcccgg cagcgccgga atgtcgatga tcgagatgtt gatgggtccg 281821 gcgctgctga gaacgtcgaa gttcagcgga atcgggtcga tcctggtgcc ggtgatggtg 281881 accgccggaa tgtcgacgga cacatcgatc ggcacgacct ccgacatcga aattccgttg 281941 atagtggagg ccgggatgtc gatcggcgga atgtcgatgg gtatggattg gctgaacgag 282001 attgccggca attcgatggc gtcgatggtc tgctgcagcg gcagggccaa tccgcccagc 282061 gttgccgaag taaggggtat ggcgacctgt atctgaaccg agattgtggg atcgggaaat 282121 tcatttggga acgcgtcgtg gaggaactga agcttgaggt taacgttgaa cggattgagc 282181 tggacgtttg agacggtgat cgggccgaac ctgaattgtc cggtaatgcc cagcgcagaa 282241 agcagggtgg tggccggggc ggtgaagccg gcgtcggcgg caccgtcgaa gtcgatgtgg 282301 attgccggaa tggggatgtc cggcacggcg aagccgtagt tcgcttgtcc cgtgaggccc 282361 aggtggatgg ggggaaggat cgtggtgtcc gggatgataa tggggccgat gccgccggtt 282421 gaagtccagt ggatcgggaa ttcgggaatc gtgatgccga cgttcaggcc gaacaggccc 282481 tcgaagttgc ctcgccacaa gatgccgttg ctgaagttgc ccgacatgag ggcgccggtg 282541 tcgacattgc ccgaattggc gacgccggtg ttggcgttgc cggtgttgaa ccagccggtg 282601 ttgatgctgc ccgggttgaa accaccggtg ttggtgtcac ccacattgaa gctgcccgtg 282661 ttgtacgacc cagggttggc cacaccggta ttgaaattac cggcattgaa aagcccagta 282721 ctgcccgttc cgccattgcc gatgccggtg ttgaagctgc ccgagttgaa caacccgaag 282781 ttcccggtcc cggagttgaa caacccgacg ttgccggtgc cggagttgaa caacccgatg 282841 ttgccggcac cggagttcaa gccgccgatc ccagtctggt tgtccccggt cagcccaatc 282901 ccgaggttgt tggtgccggt gttaccgaac ccgatgttgc ccacacccat gttgccgaag 282961 ccgacgttgc cgctgccggc attgcccaac ccgatgttgc ccaccccggc caggcccgcc 283021 gccagacccg cattgcccaa cccgaagttg gcatcgccga tattgccgaa cccgacgttg 283081 ccgccgccga cattgcccaa acccacgttc aagtcgccga tattggccgc acccaggttg 283141 aagtccccga cgttgccgaa accgacgttt acgctgccca catcggccaa cccgagattg 283201 atgatgaggc tctggttgag tgccgtcccc gccgaggaca accccgacag ctgctcacca 283261 acattgccga tgcccgagac caccgccggg gtccccggcg gcaacccgcc ggtgttgtac 283321 agccccgaca cacccgagcc gaagttcagc acacccgatc ccagcgaacc gaaattggcg 283381 aaacccgaac ccgccccagc cacctcggtc tgcgcctggt tccaccaacc cgagctgccc 283441 gcaccgaaat tcccgaagcc cgacacccca ccgtcgccgg agttgaagaa acccgacgac 283501 ggagcggtgg tcgtgttgcc aaagcccggg gtcgccggga tattaacgcc gttgatcagg 283561 atagggccga cagtgacgct ggcgccgagg ttcagcggga tgcggtcgat cgtgatcggc 283621 ggggtgctga agccgtcaat ctggccgtct atgtcgatcg tcagcggcag cggcgcagcg 283681 ggaatggtga agcccgggat cgtgaatccc agcgtgccga tcgacgcgct ggccagcagc 283741 gccagtggat tgttgggaat actgatgcca ttcgggaaga tcgttactgc cggggtactc 283801 cagttgacgg tcaccgggaa tgactggtta attctggtgt cgatattaag gttacctaat 283861 tggagggtga cgttgccggc aagatctttg atttcgattc ctgaaatgtt gacgaccccc 283921 aagccaaaga aggggccgac ggggaaagtc gtgttgaagt tctgagccgg gaacagggtg 283981 atgggcgaga tggtgatggg gccgacgctg ataggtatgg ccgtaccgcc accaaaagcg 284041 gggatcacga tgtccggaac gaccagcggg ccgaggctga aggtttggtg aatgttgagc 284101 gggatggtgg gcaaaatctg gatcggcaac acggtgatgg ggccgacgcc gccgttgagc 284161 tcgagaccaa tggggatcgc cggaatggtc gatccaccgg agagccccca caggccctcg 284221 tagtcacccc gccacagcac accgttgctg aagttgcccg agatgaacgc gccggtgttg 284281 acattgcccg agttggcgat gccggtgttg gtgttgccgg tgttcagcca gccggtgttg 284341 acgttgcccg ggttgaagcc acccgtattg gtgttgcccg cgttgaagct gcccgtgtta 284401 tagctaccca cgttggccac acccgtgttg aacccaccaa cgttgaacaa cccggtactg 284461 gccgtccccg cattaccgac accggtgttg tagctgcccg agttgaatac cccgaagttg 284521 ccggtccccg aattgaagaa cccaatgttg ccggtgccgg agttgaacaa ccccagatta 284581 ccggttcctg aattcaggcc cccaatgcca gtcaggttgt ccccggtcaa cccgatcccg 284641 atgttgttgc tacccgtgtt ggcaaaaccg atgttgccca cacccaggtt tgcgaggccg 284701 tagttgctgc tgcccgcatt gcccaaccca atattgccca tgcccggcgg caacccaaga 284761 cccgagttgc cgaacccgaa gttggcgttg ccgatattgc cgaaaccgaa attcccgcta 284821 ccggcgttgg cagcacccaa attctgcgca ccgacattgg ctgcgcccag gttgaatatc 284881 ccgacattgc ccaacccgac gttgtaatta ccgacattgc ccaagcccgc gttaagcctc 284941 aacatcttcg cgggtccggc aaatagagca ttgaggaacg cgccgacacc accccccaac 285001 gcctgcgccg gtgggctgaa cgccggcaac gccgcggcag cagccgacgc gccggaatgg 285061 tagccggcca tcgccgccac atcggcggcc cacatcaact cgtactcggc ctcgacggcc 285121 gcgatcgctg cggcgttctg ccccagcagg ttcgacatcg ccaacgcccg catcgccatc 285181 cggttgaccg ccaccgccgc cggatccacc gtcgccgcca acgccgcctc aaacgccgcc 285241 accgcggccc gcgcctgccc ggccaccgcc acggcctgcg ccgccaccga acccaaccac 285301 cccgcatacg gggccgccgc ggccgccatc gccgccgccg ccgcaccctg ccacaccccc 285361 gccgtcaggc ccgacgtcac ctgcccaaac gacaccgccg ccgaccccaa ctcctcagcc 285421 agcccatccc acgccgcggc cgccgccagc aacgggctcg accccgcacc cgaatacatc 285481 agcacggagt tgatttccgg tggcagaact ggaaaattca accgccccta cctctgccgc 285541 tcacgatgcg ttcacacctc atcgtctcac cacgacgtgg tgagcgcggg cacttcgaca 285601 aactaatctg caatatcccg atcgcgtaca aacgtgccga catttgcggc gcattaatgc 285661 ccatatcggc ttgtatctct tgtagtgccg ctttgacggg gtggtggtca ggtacggtgg 285721 cctcgggaga ggctggaggg ctcgacgttt tcggctgagt gtctgggccc gtgaaagaga 285781 tcgtctgctc cagctttgtc tcctgaactg acccggttta gggaattggt ggccaggttg 285841 cggaagtgcg cagcatcgac gtgtacctgg gtgaggcatc gaatcatcga caagcaccgg 285901 agccgcgcgt gaactcccgc cgcgttgtgg tcggggatga tgtgggagac cggccggcag 285961 tgctgtgtac gaaggttctc ccaccgcaac gagttcacgc acgacggtcg gctgggtggg 286021 ccctggaata cgtgaactct tcatcaacac aacatgattg acgatgaagg ggagaacctc 286081 catgcacaac aacgctaacc cgtgactgcc gagaatccag gacggagcag gcggacgctg 286141 gtcggaatcg acgcggcgat cacggcctgt caccacatcg cgatccgcga tgatgtcggt 286201 gcgaggtcga ttcgattcag tgtcgaaccc acgctggccg gactgcgcac cctcaccgac 286261 aagctcagcg gttacgacga tatcgacgcc accgtggaac cgacctcgat gacgtggctg 286321 ccgctcacga tcgctgtcga gaatgccggt gacaccatgc acatggccgg cgcgcggcat 286381 tgcgcccggc tgcggggtgc gatcgtgggc aagagcaagt ccgacgtcat cgacgccgag 286441 gttctcaccc gcgccagcga ggtgttcgac ctgacgccgc tgacactgcc gacgcccgcg 286501 cagttggcgt tacgtcgatc ggtgatccga cgtgccggcg cagtgattga cgcgaaccgg 286561 tcctggcgtc ggttgatgtc gttggcgcgg taggcgttcc ccgatgtgtg gaccgcgttc 286621 gccgggtcgt taccgaccgc gacagcggtg ctggggcgtt ggcccgacat ccgcttgctg 286681 gccggcgcac cgacccgcca cgttgaccgc cgtcatcgcc gcgcacaccc gcggtgtcgc 286741 cgacaccccg gcccggccga ggccatcaag accgccgcaa ccggctgggc cgcgttctgg 286801 gacgggcacc tcgacctgga cgcactggcc gtcgatgtca ccgagcatct cagcgacctc 286861 accgacgacc gatgcgcgcg ttggtgatgc cggtgaccaa gaaggtgttg atcttgggtg 286921 actagtcaat ggtggtggcc agggtgagca gttcggggat ctgcgagtcg atgcgccagg 286981 caggaagcgg tgtaggtgat ggcgcgccag gtgggggtcc ccgccggtgc gcacggtcga 287041 cagcagggtg cgcagctcct ctttggcgat ccaggccgag agaatctgcg cgcgggggtc 287101 gacggcgttg atccgattcc gcattttggc gaagcttttg tccgacaagc gttcccgggc 287161 ggtcagcaag cgacgtcggt tggcccactg cgggtcgatc ttgcggccgc gccggtcgtg 287221 gaacgcccag gtcacccggc ggcgcaccgc ggtcagcgcg tcgttggcca gcgtggtcac 287281 atggaagtgg tcgacgacga gcttggcgtt gggcagcagc ccgggcgtgc ggatcgccga 287341 ggcgtaggca gcggcggggt cgatggccac cgtactggat gctctcccgg aactgcggtg 287401 tgcgcgcttg cagccatgcc agcaccgccg cgccgccgcg gccttcatgc tgccccataa 287461 acccctgatc accggccagg tcgacgaacc cggtatccca cgggtcgacc cgtacccacc 287521 ggccagtctt ggcgcagcgc tcccatctgg gttttcctcg ccgtgtctgg tcaacgccca 287581 gcaccggggt gggcaacggc tcggtcaata cccgtctcgg cgtaggcaac aaacgcccga 287641 tgtgccgtcg gccacgacac ggcgtcagcc tgggcgacct cggcccaccg agcgggccgc 287701 atccccgatc gccttggcca tctgccgacg cagccgcagc gtgctgcgga cgcgggcagg 287761 tacctgggtg atggcctcgg tgaacggccc cagcttgcag tagtcttctc ggcatcgcca 287821 gcgaattttg ttccagcgca ccatgatgcg gtcttcgcca taaggtagat ctttcggtga 287881 ggtaaccgcg tattccttca ctgatatcga gaccaccccc gcacgacggg cacgccgccg 287941 ccgtcggctc atcggtgatc acatcgacca cccgggtccc gtcactgcgg cgctcgacac 288001 gctcaacccg tgctcctggc agcccgaaca acactgtcgt agcgtcagac acagcccttg 288061 gctccttcct cggcctgaat gcttcgcaac acttagactt cagaaggcca agggccctca 288121 gccgctaaac acgccgacca agatcaacga gctacctgcc cggtcaaggt tgaagagccc 288181 ccatatcagc aagggcccgg tgtcggcgca aaatttagcg tcgttgcgcc cacaccagag 288241 ttaccgccgc acacacggcg tgaccaccgg cgtgcattta agaatccgtt agggcccgac 288301 gccggtgaag agcaagcccg acagttgctg gccgacgttg ccgaaacccg agacgacggc 288361 cgcggtgaca acacccagcg cgccggtgtt gtacacgccc gagatgccgg cgccgcggtt 288421 gaggatgccg gagagctggg tgccgaagtt ggcgaagccc gacgccgacc cgagcagcgg 288481 atccgacatc gcgttgagca atcccgacat gcccgcgccg gtgttgctaa agcccgaacc 288541 gccgccagct ccggtgttga agaagcccga cgacggcagc gtggtcgagt tcccgaaacc 288601 cggcgccccg ccgaacccgg cgatcgggac gttgatcggg ccgatagtgg tgtcggcgtg 288661 caggtccagc aagatccggt cgagaacgat ggccgggatg tcgacgggcg ggatgccatt 288721 ggacaacgcg aggcccagcg ggagggtggg gatcagggtg ccgcccggga tggtgaaccc 288781 cgggatggtc agcgacaccg gcaggccgat gtcgatcggg tcgaggggga tggtgaatcc 288841 cgggaaggtc accgtgccgg aggggatgga gatgggcccc acaaagtatg ccccttgcgt 288901 ggacgttgca cccccgccgc tagagggcgc gatccggatt ccggggaaga agctgggctt 288961 gacccaaatc tctgaggttg gtccggacgt gctggtgacg gctccttggg agtaactgac 289021 gagcacgggc ggggtcctga cggtaatggg gttgacggtg atggagccga catggacggc 289081 ggggtcgagg cccaagtgaa tggatggaac agagatgtcc gggatggcga tcgggccgat 289141 gccaccgacc gcggcgaagc cgaccggaat gggcgggatg tggatgggcg gcagcacggt 289201 aatcgggccg atcccgccgc tgacgtcggc gcccaccgcg gggaacagcg ggagggtgta 289261 gcccacggcg aagccggcca ggccctggta gtcgccgcgc cacaggatgc cgttgctgaa 289321 gttgccggtg acgaaggcgc cggtgttgac attgcccgcg ttggccaccc cggtgttggc 289381 gttgccggcg ttgagccagc cggtgttgat gctgcccggg ttgaagcccc cggtgttggt 289441 gtcaccgaca ttgaagctgc ccgtgttgta gctgccggcg ttggccacac cggtgttgaa 289501 actgccggca ttgaagagcc cagtgctgcc cgttccgcta ttgccgacgc cggtgttgaa 289561 gctgccggag ttgaacaacc cgaagttgcc ggtcccggtg ttgaagaacc cgacgttgcc 289621 ggcgccggag ttgaacaacc ccaggttgcc ggcaccggaa tttaggccgc cgatgccggt 289681 ctggtagtcg ccggtcagcc cgatcccaat gttgccggtg ccggtgttgg ccaacccgat 289741 attgcccacg cccacgttgg ccaaccccca gttgttgccg ccggcattgc ccaaccccac 289801 attgcccagg cccggcacgc ccgcggtcag acccgagttg ccgactccga cattgccgtg 289861 gccaatattg ccgaacccca ggttgccggc gccgatattt ccgaagccca ggttgtgcgc 289921 gccgaggttg gccgcgccca ggttgacctc cccgacattg ccgaaaccgg cgttgtggct 289981 gccgacgttg gccaacccga tattcagaac ggtcaccggg ttcaccgcgg acccgccgga 290041 aagcagcccc gacagttggt ggccgacgtt gcccaggcct gagaccagcg ccggggtccc 290101 cacccccagc gtgctggtgt tgtagatccc cgagacaccc gagcccaggt tgagcacacc 290161 ggaatgcagc gtgccaacgt tggcaaaacc cgagcccgcc cccgccagcg cggtgtgcgc 290221 ctggttccac cagcccgagg tgcccgcgcc gaagttgccg aagcccgatc ccccgcccgc 290281 gccggcgttg aagaagcccg acgacggggt gatggtgctg ttcccaatgc ccggggtggg 290341 cgggatgttg atcagcggga tgctgctggc gaggacatac accgagccgt cggcgctcgc 290401 cgcgatctcg ggccaggtga tggccgggat gtccacgccg ccggcgccgg cggtcacgtc 290461 caggttcagc agcgaggtcg ccgggaacgt caaaccaccg gggaagaggg tgatcgcgtt 290521 gacgctgccg ggcacctgga agcccaacgt gatcgggcca gtttcgagct gcggagtggt 290581 aaacgccccg ctggacgcgg aaatggtgag atggcttccg tcgctcgtgc cggcgccgaa 290641 aacgagtggg ccggtggcgt agggcgaacc gtcggccgat ccgaatgaat agaaggttat 290701 accaaggcca ttagtgcctt gagtccacat ttcgaaggga tctatcctca tctccgcccc 290761 aaccgaggcg ttgattattt gctccacaat gacactcacc ggcggaatgc gcacggaccc 290821 cacaacgatg cggaaggcgg cgcttccggt gatgtttggg gtgagtgcgg ggatgtcgat 290881 ctgcggaatg gtgaatgcgc ccatcgcgac gtttccggtc aggtgcgcat taacggccgg 290941 caccgggatg ggcgggagga ccacgggtcc gaagccgccg tcgaggtggg cgtccacgat 291001 ggtgatccgg ggcacgtcga ggctgtagaa caggctgaac aggccctcgt gatcaccccg 291061 ccacaacagg ccgttgctga agttgcccga catgaacgcg ccggtgccga cgttgcccga 291121 gttggcgatg ccggtattgg tgtggccggt gttgaaccag ccggtgttga tggtgcccgg 291181 gttgaacccc ccggtgttgg tgtcgccggc attgaagctg ccggtgttgt agctgccggc 291241 gttggccacg ccggtgttga agctgccggc attgaagagc ccagtgctgc ccgttccgct 291301 attgccgatg ccggtgttga agctgcccga gttaccgatg ccgaagttgc cggtcccgga 291361 gttgaagaac ccgatgttgc cggtgccgga gttgaacaag ccgatattgc cggcaccgga 291421 gttcaggccc ccgatgccgg tgaggttgtc ccccaccagc ccgatcccga tgttgccggt 291481 gccggtgttg gccaacccga tgttgcgcac gccctggttg gcgaaaccat agttggcgct 291541 gccggcattg ccgaaccccg tgttgcccag gccggccgcg ccggcggtca gacccgaatt 291601 gccgaaaccg atattgccgt ggccgacgtt ggcgaagccg aggttgccgg tgccgacgtt 291661 gcccagcccc aggttttgcg caccgaggtt ggccgcgccc aggttaacgt ccccgacgtt 291721 gccgaacccg acgttgaagt tgcccacatc cgccaacccg atgttgagga tggggatctg 291781 gttcaacgcg gtcccggccg cagacacgcc cgacagctga tggccgacgt tgccgaggcc 291841 cgacagcacc gccggcgtcc cgagcggcaa cacgctggtg ttgtagatcc ccgagacacc 291901 cgagccgacg ttgagcacac ccgagcccag cgtgccgaca ttcaacaccc ccgatcccga 291961 ccccgccagc gcgctcgccg cctggttcca ccagcccgac aggttcgacc cgacgtttcc 292021 gaaccccgac accccaccgg cgccggagtt gaagaacccc gacgacgggg tcgccgtggt 292081 gttgccgaac cctggcgtcg gcgggacatc gatgatcggg atgctgctgt cgggcacggt 292141 gagattcagc gccaggtgca gcggcagcgg gtcgatcgtg tacccacccg ggaaaatcgt 292201 gatcggatcc agcgcgccgg acgcatcgat cgttaacggg atggcgttcg tggggatcgt 292261 caggccaccc gcgaacaagg tgaaggccgg cagaccaccg ctgatgttca cgtccaacag 292321 gaatctcgtg gtagcgattt gcggaatctc gaaacccgga atagatatct tgagctcgcc 292381 ggtcgttccg gggccagggc cggtgtgaat ggtgatgccc tgggtgggcg ccgggaaggg 292441 gtctccgaaa ttgggaatcg ccgcggtcga cccgaggatc cagtcctcgc cttcgaagcg 292501 catgctgatg agcggaagcg tcatggttga cccgggtgag gcggggatgt ccagcggaat 292561 ggttctcgtc tgtgcgggaa ttgtggtggc gggcaccagg acgatgggat ccatgtggat 292621 cgattcgtgg atctctagcg gtatcgcggg aacatcgacc tgcgggatgg tgaagggtcc 292681 gatctcgacg atttcgtgga cgtcgaacag cgacatgccg gggatgtcga tctgctcgat 292741 gtggatgggg cccaggttga gggtttcgtt gaggtccagc agggtgctgc cggcgatgtc 292801 gatgctgaag gagaagccga ccagcccgtg gtagtcaccg gtccacagcg ccccgttgtt 292861 gaagctgccg gagttgaacg cgccggtgtt gacgttgccg gtgttgaaca ggccggtgtt 292921 ggtgtggccg gtgttgaacc agccggtgtt gacggtgccc gggttgacgc cgccggtgtt 292981 gaagctgccc acgttgaggc tgccggtgtt gtaggagccg gcattggcca gaccggtgtt 293041 gaagttcccc gcgttgaaca acccggtgct ggccgtgccc gcattcccca caccggtgct 293101 gtaactgccc gagttgaaca gcccgaagtt cccggtcccg gtgttgaaga acccgatgtt 293161 gccggtgccc gagttgaaca acccgaggtt cccggtgccc gagttcaggc cgccgatccc 293221 ggtccgatag tccccggtca gcccgatccc gatgttgccg gtgccggtgt tggccaaccc 293281 gatattgccc acacccacgt tggccaaccc ccagctgccg ctgccggcgt tacccaaccc 293341 cacattgccc aggccccccg cgcccgcggt caggcccgcg ttgccgaatc cgaaattgcc 293401 ggcaccgatg ttgccgaacc cgaggttgcc ggtcccgacg ttgcccaacc ccaagttgct 293461 gccgccgagg ttgccggcgc cgacgttgat gttgccgacg ttgcccgcac ccaggttgaa 293521 ctcaccgacg ttagccaaac cgaggttcac cccgccgaca ttgcccaagg ccaaagcgtt 293581 gccgatgtcg aggtgctgca gctcggcgat ggccgcgtcg atgatctgat cgaacacgga 293641 ctcggcaggt gggaaggtga ggatcgcgat caggccatcg atggacaccc ccgacatatg 293701 gtcgccgagg ttgctgaacc ccgagatcac cgccggggtg gtggcgtcca gcgtgctcac 293761 gttgaacagc ccggagatgg cggtgccgga gttcagcaca cccgaggcca gggtgccggc 293821 attgcccagc cccgagagtg tccccaccag tgaccccgcg ccggcctggt tgagcaggcc 293881 cgacacgccc gcacccaagt tgccgatgcc cgatccgccg ccggcaccgg tgttgaagaa 293941 ccccgacgac ggcatctggg tcgagttccc gaagcccggc gccgccggga tgtcgatgat 294001 cgggatgttg aggggtccgg cactggtgcg aatgtcgaag cccagcggga tcgcggaaat 294061 ggtggtgcct gtgatcgtga ccgccgggat gtccacggac gcatcgatcg gcaccacttc 294121 cgacattgaa atcccatcga tgaccgaggc cggaatatca acaggtatgc ggataggaat 294181 cgactcactc aacgaaatcg catccagggg gatgggctcg atctccaggg gcacaccgat 294241 cccggccacc acgattggct caagatgaat tggtccgagt tggcccgtga taggaccaag 294301 aacgggcagg cctaacgtga aatccatggg cggaatatcg atattcgaga gcgtgatggg 294361 gccgaagctg atgaagctac cgttattctt cagggcggac agcagggtgg cttccggggc 294421 ggtgaagccg acggtgacga cgccattgat gccgatgtgg atggcgggga tggggatgtc 294481 gggcacggtg aagctgtagt ccgcgtcgcc ggtgatctgc aggtgcagcg gcggaaggat 294541 cgtggtgtcc gggatgacga tggggccgat accgccagtc gtggtgatgc ggatcgggaa 294601 ttgcgggatc gtgatgccat aggacaggcc gaacaggccc tcgtggtcgc cgcgccacag 294661 catgccgttg ctgtcggtcc ccgacatgag ggcgccggtg ttgcgggtgc ccgtattcat 294721 aatgccggtg ttgaaccagc cggtgttgat gtcgcccggg ttgaaaccac cggtgttggt 294781 atcaccgaca ttgaagctgc ccgtgttgta cgacccgggg ttggcgatgc cggtgttgaa 294841 attgccggca ttgaagagcc cagtactgcc ggttccgcta ttaccgatgc cggtgttgaa 294901 actaccggag ttgaacagtc cgaagttgcc ggtgccggtg ttgaagaacc cgacattgcc 294961 ggtgccggaa ttgaacaatc cgatattgcc actacccgag ttgaggccgc cgatgccggt 295021 ctggtagtcg ccgaccagcc cgatcccgat gttgcccgtg ccggtgttgg ccaacccgat 295081 gttgcccaca cccaggttgg ccagccccca gttgttgctg ccggcattgc tcaaccccac 295141 gttgcccagg ccggccaggc ccaccgccgg acccgagttg gcgaacccga cgttgccggc 295201 accgatgttg ccgaacccga cgttcccgct gccgagattg cccaggccca ggttctgcgc 295261 gccgatgttg gccgcacccc agttgaggtc ccccacattg cccaacccgg tgttgaacgc 295321 gcccacatcg gcccacccga tattgacaat ggggctccgg ttgagcacgg tcccatttgc 295381 caagaacccc gacagctgct ggccgaggtt gccgatgccc gagaccaccg ccggggtgcc 295441 cgctcccagg gtgctggtgt tgtaccaccc ggagatcccc gagccgacgt tcagcacgcc 295501 cgagctcagc gtgccggcat tggcaactcc cgagcccgcc cctgctaaca cgtcgtgccc 295561 ctggttccac cagcccgacg tgcccgcgcc gacgttggcg aaccccgatc caccgccgcc 295621 gccggtgttg aagaaccccg acgatggggc cgtggtggtg ttgccgaacc ccggcaccgc 295681 cggcacatcg atgatcggga tcgggatatc gccgatgagg atggtgccgt cgaaggtcgc 295741 cggcacggtg tcgagggtga acccgtcggg caacagcgtg aacgcgtcca gccccacgga 295801 cagtccggtg accccggcgg aggcccgcgg aaaggtcagc ccacccggga agaaggtgaa 295861 cccgtcgttg gcgacctcca tacccaccgt cacgggggtt tgcgcgggaa tggtgaaacc 295921 attcgggaaa agcgtccacg gggtggtgtc caagttgagg gttaggggaa ttggtgtcgg 295981 ggtgaccaat atctgaccgc taaccgtgag gccgggcaca atgatgttct ctaggaacaa 296041 gacaccggca acaacttgga acgcatcaat ggtgataaat gggtcactga ggcggaacgg 296101 ctcgagaaaa agccctatcg aaccggcgag cgggtcaaga gcgcgaatcg gcgagatggt 296161 gtttgcggcc aggtccacgc ttccggtgat gctggcgatg ggaagtgagg gaatgctgat 296221 cggtgggacg gtgaacggac ccaggccgac ggtggcgtcg gtgatctcga cgtgcacggc 296281 gggtaccggg acgggcgcca catgcagcgg gcccaccccg ccgatcgcgt gcacggtgac 296341 cgggaattgg gagatcgtgg gcccgacgcg gacgccgacc aggccctcgt agccgccccg 296401 ccacaacagg ccgttgctgt agtcgcccgt catgaaggcg ccggtgccga aggtgcccgc 296461 gttggccaac ccggtgttgg catgcccggt gttgaaccag ccggtgttga tgccgcccgg 296521 gttgaagcca ccggtgttgg tgtcgccggc gttgaagctg cccgtgttgt agtcaccagt 296581 gttggcgatg ccggtgctga agctgccggc attgaagagc ccggtgctgg ccgttccgct 296641 attaccgatc ccggtgttga agcggccgga gttcccgatg ccgaagttgc cggtcccgga 296701 attgaagaac ccgacgttgc cggtgccgga gttgaacaac ccgatattgc cgatgccgga 296761 gttcaagccc ccgatcccgg tccgatggtc cccgaccagc ccgatcccga tgttgcccgt 296821 gccggtgttg gcaaacccaa tattgcccac acccatgttc gccaagccat agttgttgat 296881 gccggcattg ccaaaaccaa cattgcccac ccccgccgcg ccggcggtca ggcccaagtt 296941 ggcaaacccc aggttgccat ggccgatgtt gcccaacccc aggttgccgt ccccgacatt 297001 gcccaggccc aggttgtgcc caccgatgtt ggccgcaccc aggttgacgt ccccgacatt 297061 tccgaacccg gtgttgaagt tgcccacatt ggccaacccg aggttgccgg cgagcatcga 297121 gcgcagcgtg gttcccgccg ccgacacccc cgacagctgc tggcccaggt tgccgatgcc 297181 cgacaccgcc gccggtgtcc cgaaaggcaa cacgctggtg ttgtagaacc ccgagatccc 297241 tgagcccagg ttgagcacac ccgagcccag ggtgcccacg ttgccaacac ccgaaccggc 297301 ccccaacagc gcgctcggcg cctggttcca ccagcccgag ctgcccgcgc cgacgttgcc 297361 gaaacccgac accccacccg caccggagtt gaagaatccc gacgacgggg ccgtggtggt 297421 gttccccact cccggcgccg ccgggatatg aaggccctgg atcgtgatgg ggccgatcgt 297481 gaccccgccc cccacggtca gggggatgcg atcgatcgtg atcggcgggg tgctgaaccc 297541 gtcgatctgg ccctcgatat cgatcgacaa cggcaacggc tgcgcgggaa cactaaatcc 297601 cgggatggta aagcccgggt tactgatcga cacactcacc agcaacccca aaggattatc 297661 gggagcactg atgccattcg ggaacagcgt gatcggaggg gtatcccatc tgatcgttaa 297721 atcaatctgt ggattggtgg gtccgggaat ggtggtgtcg ataacgatag ggccgataaa 297781 gctgacaagc tgaccgttag aatcaaaggt ttggatttgt ggaattgtga ttttccctaa 297841 actgaaggtg ggaaagggca attggttgac aaatgtctgt tgggcaaaca gggtgatggg 297901 tgtgatggtc agcgggccga tgttgatggg tatgccgata ccgccgccga aggcggggat 297961 cacgatgtcg ggaaccacca gcgggcccaa gttgacggtt tggtgaatgc tgagcgggat 298021 ggtgggcagg atcgggatgg gctggatggt gatcgggccg atgtcgccgt tgagcaccag 298081 gccgatggga attgcgggga tcgacgagcc ggcggagacg ccgaacaggc cctggtagtc 298141 acccacccac agcacgccgt tgttgaagtt gcccgagatg aacgcgccgg tgttgacgtt 298201 gcccgagttg gcgatgccgg tgttggtgtt gccggtgttc agccagccgg tgttcacacc 298261 gccggggttg aagccaccgg tgttggtgtc gccggcgttg aaactgccgg tgttgtaact 298321 gcccacgttc accacgccgg tgttgaaatt gccggcattg aacaaccccg tgctggccgt 298381 ccccgcatta ccgacaccgg tgttgtaatt acccgagttg aacaccccga agttcccggt 298441 ccccgaattg aagaacccca cattcccggt gccggagttg aacaacccga tattcccggt 298501 gcccgaattc aggcccccga tacccgtcag gtggttgccg gtgagcccga cgccgacgtt 298561 gttggtgccg gtgttgccga aaccgatgtt gcccacaccc aggtttgcga aaccatagtt 298621 gctgctgccc gcattgccca acccgatatt gcccaagccg gccaggcccg cccccagacc 298681 ggagttgccg aacccgacat tcccgttacc gaggttgccg aacccgacat tggtgccacc 298741 ggcattcccg aaacccagat tctgcccacc cacattgccc gcgcccaggt tgaacacccc 298801 gacattgccc aacccgacgt tgtaattgcc gacattgccc aaacccgcat tcaggctcag 298861 cgccttcgca gggctggcga acagggcggt aaggaacgcg ccgacacctc cccccagcgc 298921 ctgcgccggt gggctgaacg ccggcaacgc cgcggcagca gccgacgcgc cggaatggta 298981 gccggccatc gccgccacat cggcggccca catcagctcg tactcggcct cggcggccgc 299041 gatcgccggc gtgttctgcc ccaacagatt cgacaccgcc aacgccacca gccgcgcccg 299101 gttggccgcc accagcgccg gatccaccgt cgccgccaac gccgcctcaa agacccccac 299161 caccacccgc gcctgcccgg ccaccgcctc ggccgcggcc gccaccgaac ccaaccaccc 299221 cgcatacggc gccgccgcgg ccgccatcgc cgccgccgcc gcaccctgcc acacccccgc 299281 cgtcaggccc gacgtcacct gcccaaacga caccgccgcc gaccccaact cctcagccag 299341 cccatcccac gccgcggccg ccgccagcaa cgggctcgac cccgcacccg aatacatcag 299401 cacggagttg atttccggtg gcaacaccgg aaactccatc acccattccc cttcccagcc 299461 cgacaccaat ccccaccgac accccccaca tgacgtgtcg acgccccgat aattttgctc 299521 gcattgccaa cggcccaaga acgattcccc gataatcgcg ggtactgggt gcactttgca 299581 cagacgccgc agcaaaatgc acatatgccc tgtccagacc ggcgagcggc agggcgtcat 299641 ctgccctgac acttcgactg ctggcggagt ccgcgagcat gctcaccgcc gcggcgtgcg 299701 ccgaaccggc agcgccggca aatccatgac cccagcctgt tcttgggtca ctgcgacgtt 299761 cacttttaag cgcgaccacg taaggttggg caaagttccc aagcgtttca cagtgtcagt 299821 gcacagtgcg cacctgatta ccaaaacccc gaacctcact cgaaagccga gagcgggtaa 299881 aagtcgttca gcgacctgtc tggtagagaa atccagaccc gagtacatga tccggtcggg 299941 atcgtacttg cgccgcactg tggtcagccg cgacaggttc gcgccgaagt attgtgacgc 300001 cgcggcgttg gcctccaggt agttgacata gccgccgacc gaaaagtgtt gcaccgcgtg 300061 gtgtgcgtcg ctcagccatt tgttggccgt cgccacctgg ccgtcgctgg gggtgttgac 300121 ataccactgc accacagcgg actggcggca ccagggaaat gccgagccct ccgggtccat 300181 gtcgcccacc gcgccgccca gcgaatcgat cagagccgac gcgcggcccg cagcgggtgg 300241 ccatgttccg atggcggcga cgatggcttg ggccgcggcc ggattcgtcg tcccgatgac 300301 atcggatcca gccacgaagc cctccggcgg ataggtcgta tggccgccgg ccagatacct 300361 caccaggtcc atacggcgca gcgtcttgtg ctcaactcca ctgggttgca ctccaaccgc 300421 ggacttgatc gcatccgcga cagccgcgcc ggaccgcgcc gggcagctcg ccagcacatg 300481 acaattgcct ccggatgagc tgaccgcggg gtcaaccaga ccccacgtgg tgcggtcggc 300541 cccggccagc cacgtctgtc agccgaccag cacctgcgcg gccgcagacg gcgcgaaatc 300601 gacacggacg acatcgcagt ccgcggtggg gaacctcgcg aacgtcatcg atgtcgtcac 300661 cccgaagttg ccgcccccgc cgccacgaag cgcccagaac agctccgcgt ggtcgtcggc 300721 agacgcgctc accgcatcac cgccgggcaa caccaccgtc gccgacttga gcgcatcgca 300781 ggtcaacccc gcatggcgag aatcggcgcc taacccgccg cccagggtca aacccgccac 300841 acccacggtc gggcagctgc cggtcggaat cgcccggctc tcaccggcca acgcttgatg 300901 gaccgcatag agatcggtcg cggccgacac cgtacgtttc tcgtggcgct gtcgaaatgc 300961 accccgcccg gtaggcccag cagatcgagc accatggcgc cattggccga cgaggcgccg 301021 atgtaggaat gtccgccgcc gcgcacagcg atcttgagct tgctggccgc cgctacgaaa 301081 ccgccttccg gacgtctgcc tgcgaggcga ccgtcaccac cgcggccgga ttcaagccgc 301141 tgtagttcga attgaagatc tgctttccgc tcgtgaacgc cctgccgttg gccggcagca 301201 gcacctgccc gcctatcgat gaggccagac tggcccaccc atcacccggt gttgcgcgcg 301261 ccaatatcgt cgggaagacc gccgacgtcg ccggcgctcc gacggcgccg cgaagaaacg 301321 tctggcgaga catcacgacc gcgatcgtgt cgtatcgaga accccggccg gtatcagaac 301381 gcgccagagc gcaaaccttt ataacttcgt gtcccaaatg tgacgaccat ggaccaaggt 301441 tcctgagatg aacctacggc gccatcagac cctgacgctg cgactgctgg cggcatccgc 301501 gggcattctc agcgccgcgg ccttcgccgc gccagcacag gcaaaccccg tcgacgacgc 301561 gttcatcgcc gcgctgaaca atgccggcgt caactacggc gatccggtcg acgccaaagc 301621 gctgggtcag tccgtctgcc cgatcctggc cgagcccggc gggtcgttta acaccgcggt 301681 agccagcgtt gtggcgcgcg cccaaggcat gtcccaggac atggcgcaaa ccttcaccag 301741 tatcgcgatt tcgatgtact gcccctcggt gatggcagac gtcgccagcg gcaacctgcc 301801 ggccctgcca gacatgccgg ggctgcccgg gtcctaggcg tgcgcggctc ctagccggtc 301861 cctaacggat cgatcgtgga tgcgatgtag accatggccg ccgcgaccgt cacggtcgtc 301921 acgaaatcga tccccttgct gcgcaccacc aacaggccgg cccgttcctc ggacaacacc 301981 aaccgcagca ccgccgccac cccaacgccg ataccgatca gcagcgcacc acggcgccag 302041 aagttagccc ccgccagcac gaaccccacc gcgaagatcg acccaaccag caggatcggc 302101 cactgggcgc caacagtgcg ccggaaaacg gccctcacgg tcatcgccgc tcagccagct 302161 ccacgacatt ggtcaacaag aacgcccggg tcaacgggcc cacgccgccc ggattgggtg 302221 acacgtggcc ggcgagctcc cacacatcgg gatgcacgtc gccgaccagt ccgtcatcag 302281 tgcggctgac gccgacgtcg attaccgcgg cacccgggcg caccatgtca gccgtcaaca 302341 ggtgcgccac cccgaccgcg gccacgacga tgtcggcctg ccgggtcaac gcgggcaggt 302401 cgcgggtacc ggtgtggcac aacgtcaccg tggcattctc cgagcgccgg gtcagcaaca 302461 gccccagcgg ccggcccacc gtcacaccac gaccgataac gaccacatgc gcgccggcga 302521 tcgagatgtc gtagcgccgc agcaggtgca caatgccgcg cggagtacac ggcagcggcg 302581 ccggggtgcc cagcaccagc cggcccaggt tggtcgggtg caacccatcg gcgtccttgg 302641 ccgggtcgac gcgctccaac gccgcgttct cgtcgagatg cttgggcaac ggcaactgca 302701 cgatgtagcc ggtgcagtcg gggttggcgt tcagttcgtc gatggtctca ttcagcgtgg 302761 cggtgctgat gtcggcgggc aggtcgcggc gaatcgacgt gatgcccacc ttggcgcaat 302821 cagcgtgctt accgcgcacg taggcctgcg accccgggtc gtcaccgacc aggatggtgc 302881 ccaagccggg cgtgcggccc gccgcgtcca atgcggccac ccgctgcttg aggtcaccga 302941 agatctcgtc gcgggtagcc ttgccgtcca gcatgatcgc gcccacgcca gccagtctgg 303001 catgcgtgtc cgcggtgccg atggcgacga cccgctcacg cgcccaccgt acggacaact 303061 tgtaccattg tggtacagat tatccgtaca tctttctaag agaggacgca tgagcatcag 303121 tgcgagcgag gcgaggcagc gcctgtttcc actcatcgaa caggtcaata ccgatcacca 303181 gccggtgcgg atcacctccc gggccggcga tgcggtgctg atgtccgccg acgactacga 303241 cgcgtggcag gaaacggtct atctgctgcg ctcaccggag aacgccaggc ggttgatgga 303301 agcggttgcc cgggataagg ctgggcactc ggctttcacc aagtctgtag atgagctgcg 303361 ggagatggcc ggcggcgagg agtgagaagc gtcaacttcg atcccgatgc ctgggaggac 303421 ttcttgttct ggctggccgc tgatcgcaaa acggcccgtc ggatcacccg gttgatcgga 303481 gaaattcagc gtgatccgtt cagcgggatc ggcaaacccg agccgctcca aggtgagttg 303541 tcgggatact ggtcgcgccg gatcgacgac gaacaccggc tggtgtatcg agcgggcgac 303601 gacgaagtca cgatgctgaa ggcccgatac cactactgat ttgggggctg gtggtattcc 303661 ggcgggctta agctccccat gtggctcccg gcagctgcga agccccggac gtgttcaacc 303721 cggccaaact cggtccgctc acgctgcgta accgggtcat caaggccgcc accttcgagg 303781 cccgcacacc tgacgcgttg gtgaccgatg acctgatcga gtaccaccgg ctgccggccg 303841 cgggcggggt cgccatgacc accgtcgcct attgcgcggt ctcccccggc ggacgcaccg 303901 gcggcaacca gatctggatg cgcccgcatg cggtgccggg actgcgccgg ctcaccgagg 303961 cgatacacgc cgagggggcg gcgatcagcg cccagatcgg ccacgccggc ccggtggccg 304021 acgcccgctc caaccaggcg accgcgctgg ctccggtgcg gttcttcaat ccgatcgcta 304081 tgcggttcgc ccagaaggcg acccgcgagg acatcgacga tgtgctggcc gcgcacgccc 304141 atgccgcccg gctggccgtc gacgccggct tcgacgccgt cgaaatccat ttggggcata 304201 actatctggc gagcgcgttt ctgtctccgc tgctcaaccg gcgtgatgac gagttcggcg 304261 gttcgttgca gaaccgggcg aaggtagctc gcggattggt gatggccgtg cgccgcgccg 304321 tccggcagca ggtcgcggtg accgccaagc tcaacatgac cgatggcatc cgcggcggca 304381 tcacagtcga cgaggcactg accaccgcca ggtggctgca ggacgacggc gggctagacg 304441 cgatcgagct caccgcgggc agctcgctgg tcaacccgat gtatttgttc cgcggcgacg 304501 cgccggttaa ggagttcgcc gccgcgttca aaccaccgct gcgctggggc atccggatga 304561 ccggccatag gtttttccgc gaatacccct accgcgatgc ctatctgtta cgcgaggctc 304621 ggttgtttcg cgccgagctg acaatcccgc tgattctgct gggcggcatc accaaccgaa 304681 cgaccatgga cctggcgatg gccgaagggt tcgagttcgt cgcgatggct cgggcgctgc 304741 tcgccgagcc cgacctggtc aatcggatcg cggccgaagg cagccaggtg cggtcggcgt 304801 gcacacactg taatcagtgc atggccacga tttatcgccg cactcactgt gtggtcaccg 304861 gggctccata gcgtccagat tgacgccacc gtgaagaagt gcaacccatt gtgccggaaa 304921 tccggttgac ttccccgcgc gaatccggct caggcactat tgaccgcgcg cagcataatt 304981 tgaaccgatg agtcgacccc atccaccggt gctgacagtt cggtccgatc ggtcgcagca 305041 atgcttcgcc gcgggccgcg acgtggttgt cgggagtgat cttcgtgccg acatgcgcgt 305101 ggcgcaccca ctgatcgccc gtgcgcacct gttgctgcgc ttcgatcggg gcaattggat 305161 cgcgatcgac aacgattcgc agagcgggat gttcgtcgac ggccagcggg tgtcggaagt 305221 cgacatttat gacggcctga ctatcaacat cgggaagccc accgggccgt ggatcacctt 305281 cgaggtcggc catcaccagg gcatcatcgg acggctgtca cgcaccccgt cgtcgcgtcc 305341 cggctcaccg atctagcccc ctgccaagca cagcccgtgc gccgccgcaa aggccacggc 305401 ttggtcgacg tcgacacgcg cacccaccaa cgacgcggtc cgccacaata ccgggtccac 305461 ggtcgcgccc cgcaagtcgg cgtcatccag ccgggcgccc gtggtacggg caccactgag 305521 gtcggcgccg cgcagcacgc acttgcgcaa gtcggtatcc accaggctgg tctctcgcaa 305581 ccggcagccg gtcaagttga gaccacgcag atcatttccg ccgagcacgg cgagcgtgaa 305641 atccacgtcg tccaacgtca gcggccgcag ccggcaagcc acgaagaccg agcccaacat 305701 gctgcactgg gcaaatgtgc tgtgccacag tgtcgtccgt tcgaaggtgc aattacgaaa 305761 cgccgaccct cggtgttgtg actcggccag attcacgccg ctgaaatcgc attcgctgaa 305821 catcgcccgt tcggtgtgca ggcggctaag gtcctcgtcg cggaagtctc gaccggtgaa 305881 ttcgcaatca acccactgct gcaacgcttt tcaaccgccc gcaggagaca gggtggccag 305941 cgcgtattcg ctcaccgcga tcagtgcatc ggtcgccgac ctgcgattgc gggcgtcaac 306001 attgatcacc ggaatgtgtg cgggcagcgt caacgcgtcg cgcaccgcgc taaccggata 306061 ccttggcgcg ctgtcgaact cgttgatggc gatcaagaac ggcaggttgc ggtgttcgaa 306121 gaagtcgacc gccgcaaagc tgtcctgcag acgccggcag tcgaccaaga cgatcgcccc 306181 gatggcacca cgcaccaggt cgtcccacat gaaccagaac cggcgctggc ccggggtacc 306241 gaatagataa agcaccagat cctcgcccaa ggtgatgcgg ccgaagtcca tcgccaccgt 306301 ggtgctccgc ttgtcgggag tggcctccag catgtcgacg ccggcggagg catcggtgac 306361 catcgcttcg gtgcgcaacg gcatgatctc cgaaacagcg ccgacgaatg tggtcttgcc 306421 ggacccgaat ccgcccgcga tgacgatctt cgtcgacgcg gtgccggatg cctcagagtg 306481 ctttaaggcc acgcagggtc cttcctatga gttcgtggcg ttcgtcgcgg gtcgatcggt 306541 cggtcaaggt cgcgtgcacc cgaaggtaac cggacgtgac cagatcaccg accagcacac 306601 gcgccacacc caccggcaaa tccagccgag ccgagatttc cgcgaccgac ggactgccaa 306661 tgcacaattg caagatcctg cgtcgcatgt cgtaggccgg ccagcggcca gccggtcccg 306721 ccggcagggt ctgcaccggc gcctgaagcg gaaggtcgac gtcggtaccg gtacgtccgg 306781 cggtcagcgt gtaggggcgg accaggcccg ccttcggtct atcgccggca ggattgaaca 306841 acgccgccca cccgctcgac aaggatggcc atctcataac cgatctggcc gatatcgcat 306901 ccggtcgcgg ccagcgccgc cagcgccgac ccgtctccca cctgcatcaa cagcaggtag 306961 ccgttctgca tctcaaccac cgactgcagc acctgcccgc cgtcgaacag ttgcgcggcg 307021 ccgccggcca ggctggccag cccggacgtc accgcggcca actgatcggc gcgttcgcgt 307081 ggtagatgtt cgctggccgc cacgggaagc ccgtcgaccg acaccagcaa tgcatgggcc 307141 accccgggaa cctcgcgggc gaacttcgac accagccagt caagcgggct gtccggcaag 307201 cgggctttca ttgctgattg ggtccctgac tgctctcgcg ggcatgcgac cgcccggtgc 307261 gcacgccgcc gaaatggctg ctgatggagg cacgaaccgc gtcggggtcg cgtaccgcag 307321 ccgcgtgccg cggcgctcgg ccgggatgaa gtccgccgtt ggatgctagc gctgcacccg 307381 gatgctcccg atcgggtccc tcaggcaccg ccgcccccgg cactaaccgg gccccgggtt 307441 cgcgcaccgg caggccgtag tccgtgcggg actgcacggg cttgtccgcg gcctcggcgg 307501 ccgccgacca gccgtggtcc cacaccgact tccagtccag atcggggctg tgggccagct 307561 cgtgcgggtc acccaccatc tcggagagca tccgccggta gatgacgtcg tcatcaaccg 307621 ggcccgccgg tggcgcgggt ttggcgggcg gcggcgccgg tcgcggttct ggtgcgggcg 307681 gttgtttggg ctcctgttga aacctatcct cccaccaggg tgttttcagc tcgcgccgcc 307741 gctgctgcat cggctgggcc gggacgtcgg cgatgccact ggaccccggg gtacggcgcg 307801 ggagcaacgt gaccggtggt agcggcccga tggcggcggg aacgtccgtc ggatcggccg 307861 ccgcgggttc aggacacggc ggcttgatcg caaatacccg cggctttggc ggctgcgctg 307921 gggccgtccc ctcgagcacg gctagcggca ggtagacctc ggcggtggtg ccggtgccct 307981 gttcaccggt caccggaccg cgcagcccga ctcggatgcc gtgccgaccg gccagccggc 308041 cgactacgaa cagacccatg tgccgggcac tatccggggt gacctcaccg ccggcccgca 308101 gccgcatatt ggccatccgc cgatcggcat cggtcatgcc caggccggaa tccgagattc 308161 gcagcagaac actgccttcg ctgccgattg cggcggcaac ccgaacgggt gtggtcggtg 308221 acgagtagcg caacgcgttg tcgatcagct cggcaagcag atgaatgacg ccaccagccg 308281 ctgcgccgac taccgcacag tcgggtaccc tcgcgatgtc gacgcggcga tagtcctcga 308341 cctctgacac ggcggcgctg atcacggttg acagcggcac cggctcgcgg tggtcacggg 308401 taatctgcgc accggccagc accagcaggt tggcgctgtt gcggcgcagc cgggcggcca 308461 ggtgatcgag ccggaaaagg ctgtcgagtc gggcgggatc ctcctcgttg cgctccagtt 308521 ggtcgatgac cgacagctgc tggtcgacca gggaacggct acgccgcgac atggtctcaa 308581 acatctcgtt gaccagcagt cgcaaccgcg tttcctcgcc ggccagcaac agggcccggg 308641 tgtgcagctc gtcgaccgca tgcgcgacct gaccgatttc ctcggtggtg tacaccgcca 308701 gtggctcggg gatcggctcg tcgccggcgc ggaccgccgc gatctcgccg tcgagatcgg 308761 tatgagcaac cttgagcgcc ccatcacgca gtacccgcat cggcccgacc agcgtgcgcg 308821 ccaccaccaa cacgacgacg atcgcggtcg cgatggcggc caacaccagc acggcgtcgc 308881 gaatcgcggc atcccgccgg tcggtggcct ggctttgcac cgacttcgtc accgcctcgg 308941 tggtgtcggt gatcacctgc tcggcaatgt cgcgggtgat ctgtatcgag tgcagcagct 309001 ctgggttgtt gaccagtgca acggccggat cggacatgat cgccatcctg gtcaccattt 309061 gctgctgcag gttcttggtg tccggcgagc ctgcaccgag cgccgcgctc atcccgaaca 309121 gcgtcgaggg ttcggtgccg gccagggtaa ccatcgcgct gcgcagttgc ggctcggcaa 309181 ggtcggcgcc gcgagtcacc aggatctcct gcatcgtcat ctgcccgcgg gcgccaacgg 309241 ctcggctcaa accctgcacc tgggttcgga tttgctcgct gtcaacccgc accgacgcgt 309301 caatcacgtt ctgggccgtc aacagcagcg gcgcgtaggc ggtgacccga tcccgcaagc 309361 cgatgctgtc ggccagcacc ttatccagca gcgcctgacc gccgttgagc agcgtgttca 309421 ctcccgaccg cacgtctgcg atgacgtcgg tgtcggccag tcgcgtctgc agctcgtact 309481 tgcgggcggt gaagtttttc tgcgccccct ccacatcgtg tccggtcgag ctggccagca 309541 cggcgacgtc cagcgccgac atgtatttcg tgatcgcggg tatcatttcg gcgcgcgcgg 309601 cgaccagccg caggccgctg gtgctggcca tcgcagcctc gacccgcaat cctgctaaca 309661 ccatcgccac taccagcggc agaagcgcga tcgtgaacac tttccatcgg accggccagt 309721 tgcgcggcga ccaggacggc gggcgttgct gaggtttgcc gcgggccggt tgagccgggg 309781 cggaaatatc agaagcggcc gccgcgaccg ggatggtcgg gcgggcgaac atggtcacgt 309841 ggccgcggcc gtgccaccgg ccgcaccctt atgcagcgct cgaaaaacgg agagactcat 309901 agacttcctg ctcatgcctt gatgccgtcc gccccagccg gccgggcgcg gacgtaaaca 309961 actggcaatc cgacgagtat gacagcccac ggccgaggtc tccaccgctg tcaccgagca 310021 tgtcaccgga caggccggca aacgggcacc gggcgctttg ccatgatcgg cggatgttcc 310081 ggctgctgtt cgtatctccg cgtatcgccc ccaacaccgg caacgccatc cggacgtgcg 310141 ccgcaaccgg ctgtgaactg catctggtcg agccgctcgg cttcgacctg tccgaaccca 310201 agctgcgacg ggccgggctg gactaccacg acctggcctc ggtcaccgtt catgcctcgc 310261 tcgcgcacgc ctgggaggcg ctgtcgccag cgcgggtgtt cgccttcacg gcgcaggcga 310321 cgacgttgtt caccaacgtc ggctaccggg ccggtgacgt gttgatgttc gggcccgaac 310381 ccaccggcct ggacgaggcc accctggctg atacgcacat caccgggcag gtgcgcattc 310441 cgatgctggc gggccggcgc tcgttgaacc tgtccaacgc cgcagccgtc gcggtctacg 310501 aggcctggcg tcagcacggc tttgccgggg cggtctagtc gcgaccaagg tgacaccgaa 310561 ccagccggta tgcgcacaac gaagctcatc ggcgtcgggc gccggacagg agcacccaac 310621 cggtgacagc acaccgaacg caacccgggc gatcacatcg gaccacgaca tcccgggaaa 310681 atcgatgccg gtgagcttgc gcgtccagct accaccaccg tcagcggtga caccttcacc 310741 ggcaacaacg gcagcgcagg cgcagctgtc agcggcggcg cgcagcgaag gcgttgcggt 310801 caatgaatct gccgcaaacc ccacgcccgt tggcccatat tgcgctagca tccgggtgtt 310861 gtgatctcgc aggttgcgtg ctggcagcct gggggtgggt tgtgatgtcg tttgtcgtag 310921 cagtcccgga ggcattggcg gcggccgcgt cggatgtggc gaacatcggt tctgcgctaa 310981 gtgccgcgaa tgcagcggca gccgccggca caacggggct actggcagcc ggtgccgacg 311041 aggtctcggc cgccctggcg tcgctgtttt ccgggcacgc tgtgagctac caacaggtcg 311101 cggcccaggc gacggcgtta cacgatcagt ttgtccaggc cttgaccggt gccggcggat 311161 cgtacgccct caccgaggcc gccaacgtcc agcagaatct gctgaacgca attaacgcgc 311221 ccactcaggc gctgttgggg cgcccgttaa ttggcgacgg ggctgtcggc accgccagca 311281 gccccgacgg gcaagatggc ggtctgctgt tcggcaacgg gggcgccggc tacaacagcg 311341 ccgccacgcc cggaatggcc ggcggcaacg gcggcaacgc cggattgatc ggcaacggcg 311401 gtactggcgg gtcgggcggt gccggcgcgg ccggtggcgc cggcggcagc ggcggctggt 311461 tgtacggcaa cggcggaaac ggcggcatcg gcgggaatgc gatcgtcgcg ggcggtgccg 311521 gcggcaatgg gggcgctggc ggcgccgccg gattgtgggg cagtggcggc agcggcggcc 311581 aaggcggcaa cggtctgacc ggcaacgacg gcgtgaatcc ggcccccgtc acaaaccccg 311641 cgctaaatgg cgccgccggc gacagcaata tcgagccgca aaccagcgtc ctgatcggca 311701 cccaaggcgg tgacggcacg cccgggggtg ctggcgtcaa cggcggcaac ggtggcgcgg 311761 gcggagacgc caatggcaac cccgcaaaca cctcgatcgc caacgcaggc gccggcggga 311821 acggcgccgc cggcggtgac ggcggtgcca atggcggtgc gggcggcgcc ggcgggcagg 311881 ccgcgtccgc cggtagttcc gtcggcggtg acggcggcaa cggcggtgcc ggcggtacgg 311941 gcacgaacgg gcacgccggc ggtgcgggcg gcgccggcgg tgccggtggt cgcggcgggt 312001 ggctggtcgg caacggtggc aacggtggca acggtgccgc cggcggcaac ggcgccatcg 312061 gcggtaccgg tggtgccggc ggcgtccccg ccaaccaggg cggtaacagc gccctaggca 312121 cccagccggt cggcggcgac ggcggcgacg gcggcaacgg gggcaccgga ggcaccggcg 312181 ggcgtggcgg cgacggcgga tccggcggcg cgggcggcgc gagcggttgg ttgatgggca 312241 acggcggcaa cggcggcaac ggcggcaccg gcggctcagg cggtgtcggc ggcaatggcg 312301 gcatcggcgg tgacggcgcc ggcggcggaa acgccacgag cacgtcgagc atccccttcg 312361 acgcccacgg gggtaacggc ggcgctggtg gcgacgctgg tcacggcgga acgggcggcg 312421 acggcggtga cggggggcat gccggcaccg gtggacgtgg cgggttactg gccggccagc 312481 acgccaactc cggcaatggc ggtggcggcg gtaccggcgg tgccgggggc acccatggca 312541 cccccggcag cggcaacgca ggcggcaccg gcaccggtaa cgctgacagc acaaacggcg 312601 ggccaggcag cgacggcctc ggcggggacg cgtttaacgg cagtcgcggc accgacggca 312661 accccggcta attaccagcc gttccagtgc gtcacgctct cggccggcag ccgcttggcc 312721 ggccggaagt cgatgccttg tgtgtaggcg atcggaagca gcccgccttg gctgtattcg 312781 tcgtagggaa tgccgagcac gtcggccacc ttgtgctcgc cgttgtcgag caggtgcagc 312841 gtcgtccagc acgaacccag cccgcgggag cgcagcgcca ggcagaagct ccacaccgcc 312901 gggaacagtg aggcccaaaa cgacacgcca cccaccgccg actcgtcttc ccggcctttc 312961 aggcagggga tcagcagcac cggcgcccgg tgcatgtgtt cggcgagata ggtcgccgaa 313021 tcgcggaccc gccccatccg ctcgccgcgg gtgtcgccgt cggggtactc gggcgccggc 313081 ccgctgaggt agccccgggc gttggccagg tagacgtcgg cgatcgcctt tttcttggcg 313141 gcgtcctcga cgaacaccca ctgccagcct tgggaattgg aaccggtggg cgcctgcagc 313201 gccagctcga ggcattccat cagcacgtcg cgtggcaccg gcttgtcgaa atcgagacgc 313261 ttgcgcaccg agcgggtagt ggtcaggacc tcgtcgacgg acaggttgag ggtcatgtgg 313321 gcaggctacc gttgggccat gagcgtcgaa ctgacacaag aggtttctgc caggctcacg 313381 tccgaccttt acgggtggtt gaccaccgtc gcccgatcgg ggcagccggt tccgcggctg 313441 gtgtggttct acttcgacgg gaccgacctg acggtgtact ccatgcctca ggcggccaag 313501 gtcgcccaca tcaccgccca tccgcaggtc agcctgaacc tggactccga cggcaacggc 313561 gccgggatca tcgtggtggg cgggacggcg gcggtggtgg ccaccgatgt cgactgccgc 313621 gacgacgcgc cgtattgggc caagtaccgc gaggatgccg cgaagttcgg gctgaccgag 313681 gcgatcgccg cctacagcac ccggctgaag atcaccccga cccgggtgtg gacgacgccc 313741 acgggctgag cgggctggcc cccgctcgcc gccagagtga aatccacgac gcgtttgcgg 313801 cgtgtcgcgt cgcccgtttc actgtcggcg cagaggttca ccggaagtcg cgcgagcgcg 313861 cgccgaccgc cagggtgagg cggcccatcc gttcggcgac gacggtgatt gcgccgctgg 313921 cgttttggac ctggccgcgg atcagcagcg ccggcgccgt gtgcgcgagc ttgcggtgtc 313981 gcgcccacac cccgggcgtg cagagcacgt tgaccatccc ggtctcgtct tcgaggttga 314041 tgaacgtcac cccctgggcc gtggcgggtc gctgccgatg agtcaccgcg ccggcgatca 314101 gcacgcggtc gccgtcggac accgatccca gcctctcggc gggcagcacc cccatcgcgt 314161 ccaggtccgc ccgcaggaac tgggtcggat agctgtccgg ggagacgccg gtggcccaca 314221 cgtcggcggc ggccagctcc agctcgctca tccccggcag cgccgggatg tgcgacgacg 314281 agcccacccc gggtaaccgg tccggccggc ccgtggccgc ggccccggcc gcccacagcg 314341 cctcccgccg agacatgccg aagcagccca gcgccccggc cgtcgccagc gcttcgacct 314401 gcggcacgga aagctgcacc cgcgacgtca agtccggcag ggaggtgaac gggccgttgg 314461 ctgttcgctc cgcgaccagc ttctcggcca gctcggcgcc gaggtagcgg acggcgccca 314521 agcccaaacg cacctccgtt ccggcgttct cacacgtggc gtgcgccagg ctggcattga 314581 cacacgggcc gtgcaccgcc acgccgtgcc ggcgggcgtc ggccaccagc gactgcggcg 314641 aatagaaacc catcggctgg gcgcgcagca gcgccgcaca gaacgccgcc gggtggtgca 314701 gcttgaacca cgccgagtag aacaccagcg acgcgaaact cagtgcgtgg ctctcgggga 314761 agccgaaatt ggcaaacgcc tccagctttt cgtagatccg gtcgatcacc tcgtcggggg 314821 cgccgtgcag cgcgcgcatg ccgtcgtaga accggccgcg cagccggcgc atgcgttcgg 314881 tggagcgttt ggaccccatg gcgcggcgca gctggtcggc ctcggcggcg gaaaagccgg 314941 cgcagtcgac cgccaactgc atcagctgct cctgaaacag cggcactccc agcgtctttc 315001 gcaatgccgg cgccatcgac gggtgctcgt agatgaccgg gtcgacgccg ttgcgccgcc 315061 ggatgtaggg gtgcaccgat ccgccctgga tgggcccggg gcggatcagc gccacctcca 315121 ccaccaggtc gtagaacact cgcggcttaa ggcgcggcag ggtggccatc tgcgcacgtg 315181 actccacctg gaacacgccg acggaatcgg cgcgggccag catctcatac accgccggct 315241 cggagaggtc gaggcgggcc aggtccacct cgatgccctt gtgctcggcc accaggtctt 315301 tcgcatagtg cagcgccgag agcatgccca gcccgagtag gtcgaatttc accaagccga 315361 ttgccgcgca gtcgtctttg tcccattgca ggacgctgcg gttggccatg cgcgcccatt 315421 ccaccgggca cacgtcggcg atcgggcggt cgcagatgac catgccgccg gagtggatgc 315481 ctaggtgccg cggcaggttg cggatctggg tggccaggtc gatcacctgc tcggggatgc 315541 cgtcaacgtc gtcggcctgc ccggtccagt ggctgacctg cttgctccac gcgtcctgct 315601 ggcccggcga gaagcccagg gcgcgggcca tgtcacgcac cgcgctgcgc ccccggtagg 315661 tgatgacgtt ggcgacctgg gcggcgtagt cgcggccgta tttgtggtag acgtactgga 315721 tgaccttttc gcgctgatcc gactcgatgt cgatgtcgat gtcgggtggc ccgtcgcggg 315781 cgggcgataa gaagcgctcg aacaacagct cgttggccac cgggtcgacg gcggtgacgc 315841 ccagggcata gcagaccgcg gagttggccg ccgatcccct gccctgacac aggatgtcgt 315901 tgtcccggca aaaccgggtg atgtcgtgca ccaccaggaa gtagcccgga aatctcagtt 315961 gggcaatgac tttcagctca tgctcgatct gggagtacgc ccggggcgcg ctcttgggcg 316021 gcccgtaacg ctcgcgggcg cccgccatga ccaacgaccg cagccagctg tcctcggtgt 316081 gcccgtcggg aacatcgaac ggcggcagcc gcggcgcgat gagctgtagg ccaaaggcgc 316141 accgctcgcc gagctcggcg gccgcggtca ccgcctcggg gcaccacgcg aacaaccggg 316201 ccatctcctc cccggaccgc aggtgcgccc cacccagcgg agccagccac ccggccgcgg 316261 agtccagcga ccgccgggcc cggatggccg ccatcgccat cgccagccgc ccacgtgacg 316321 gatccgcgaa gtgcgccccg gtggtggcga cgatgccgac accgaagcgc ggcgccagtc 316381 cggccagcgc ggcgttgcgt tcgtcgtcga gcgggtgacc atgatgggtc agctcgatgc 316441 tgacccggct gggggtgaac cggtccacca gatcggccag cgcccgctgc gccgcggccg 316501 ggccaccctg ggaaagcgct tggcgcacat ggcctttgcg gcagccagtc aggatgtgcc 316561 agtgcccgcc ggcggcctcg gttagcgcgt cgaagtcgta gcgcggctta cccttttcgc 316621 cgccggccag atgcgccgcc gccagttgcc gcgacaaccg ccggtagcct tccgggccgc 316681 gggccaacac cagcaggtgc gggccgggcg gatccggccg ctcggtgcga gccgtggcgc 316741 ccagtgacag ctcggcgccg aagaccgtgc gcacgtcgag ttccgcggcc gcttcggcga 316801 accgcaccgc cccgtacagg ccgtcgtggt cggtcagcgc cagggcacac aggcccagcc 316861 gggcggcctc ctcgaccaac tcctcgggcg tgctggcccc gtcgaggaag ctgtacgccg 316921 aatgcgcatg cagctcggca tacgcgacgg acgatccgac ccgttcccgg cccggcggct 316981 ggtacgcccc gcgcttgcgg gaccgtggga cgtccccatc cgcgtcgaac gccggcaccc 317041 cggcatggcg cggcttgccg ttaagcaccc gttccatttc cgcccagctc ggcggcccgt 317101 tgctccaccc cacattccac agtatatcga acaattgttc gatacagcgc agttgttcag 317161 cacatcttca cctgcgaaac atgttcttaa ccgtttgggc cttctgcttc cggtgcggtc 317221 cggcggacac ttatacctgg ggtcgcaaaa cgacggtggg gacttgtcat ggcacaactg 317281 acggcactgg atgcgggttt tctcaagtcc cgcgatccgg agcggcaccc gggcctggcg 317341 atcggcgcag ttgccgtcgt caacggtgcc gcccccagct acgaccagct caaaacggtt 317401 ctcacagaac ggattaagtc gatacctcga tgtacccagg tgttggcgac cgagtggatc 317461 gactatccgg gattcgacct cacccagcac gtgcgacggg tggcgcttcc ccggcccggc 317521 gacgaagccg agctgttccg ggccatcgcg ctggcactgg agcgtcccct cgacccggac 317581 cgcccgctgt gggaatgctg gatcatcgaa ggcctcaacg gcaaccgctg ggcgatcttg 317641 ataaaaatcc accattgcat ggccggcgcc atgtcggcgg cccacctgct ggccaggctc 317701 tgcgacgatg ccgacggcag tgccttcgct aacaatgttg atatcaaaca gattccgccg 317761 tatggcgatg cgcggagctg ggccgaaacg ctgtggcgaa tgtccgtcag catcgctggc 317821 gccgtctgca cggccgcggc acgcgccgtc agctggccgg cagtgacgtc accggccggc 317881 ccggtcacca ccaggcggcg gtaccaagcg gtgcgcgttc cccgcgacgc cgtcgacgcc 317941 gtgtgccaca agttcggggt gaccgccaac gacgtcgcgc tcgcggccat caccgagggc 318001 ttccgaacgg ttctgctgca ccgcggccag caaccgcgcg ccgactcact gcgtaccctg 318061 gagaaaaccg atggcagctc ggccatgctg ccctatctcc ccgtcgagta cgacgacccg 318121 gtgcggcgat tgcgcaccgt gcacaaccgg tcacagcaga gcggccgtcg tcaacccgac 318181 agtctgtcgg actatacgcc tctcatgttg tgcgccaaga tgattcacgc gctagctcgg 318241 ttaccgcaac aaggcatcgt caccctggcg accagtgcac ccaggccacg ccaccagtta 318301 cggctgatgg gccagaagat ggaccaggtg ctgcccatcc cgcccaccgc actgcagctg 318361 agcaccggga tcgcggtcct cagctacggc gatgagctgg tgttcggcat caccgctgac 318421 tatgacgccg cgtccgaaat gcagcagctg gtcaacggta tcgaactggg tgtggcgcgt 318481 ctggtggcgc tcagcgacga ttccgtgctg ctgtttacca aggatcggcg taagcgttca 318541 tcccgcgcac tccccagcgc cgcgcggcgg gggcggccct ctgtgccgac cgcccgagcg 318601 cgtcactgac gccatctccg tcggcgttga cccccgtgag agggtgggtc gtgcgcaagt 318661 tgggcccggt caccatcgat ccgcgccgcc atgacgcggt gctgttcgac accacgttgg 318721 acgccaccca ggaactggtc cggcaactcc aggaagtcgg tgtgggcacc ggcgtcttcg 318781 gtagtggcct agacgttccg atcgtagcgg ccggccgtct ggcggtgcgg ccgggccggt 318841 gcgtggtcgt ctcggcccac tcggcgggcg tcacggccgc acgcgaaagc ggatttgcgc 318901 tgatcatcgg tgtcgaccgc accgggtgtc gggacgcatt gcgtcgcgac ggcgccgaca 318961 cggtggtcac cgacctaagc gaggtcagcg tgcgcaccgg ggaccgacgc atgtcgcagc 319021 tgcccgacgc gttacaggca ctcggcctgg ccgacggcct ggtcgcccgg cagcccgcgg 319081 tgttcttcga cttcgacggc acgctgtccg acattgtcga ggatcccgac gcggcctggc 319141 tcgcccccgg tgccttggag gcactgcaga agttggccgc gcgctgtccg atcgcggtgc 319201 tcagtggccg cgacctggcc gacgtgacac agcgggtggg tctgcccggc atctggtatg 319261 ccggcagcca tggtttcgaa ttgaccgcac ccgacggaac gcaccaccag aacgacgccg 319321 cggcggcagc cataccggtg ctgaaacagg cggctgccga gctgcgccag caacttggac 319381 ccttcccggg tgttgtggtg gagcacaagc ggtttggcgt cgccgtgcac taccgcaacg 319441 cggcccggga ccgggtcggc gaagtcgccg cggcggtgcg cacggccgag cagcgtcatg 319501 cgctgcgggt gacgacgggc cgcgaagtca tcgagttgcg tcccgatgtc gactgggaca 319561 aggggaaaac gctgctgtgg gttcttgacc atctgccgca ttcgggctcg gctcccctgg 319621 tgccgatcta cctcggcgac gacatcaccg acgaggacgc tttcgatgtg gtcggccccc 319681 atggtgttcc aattgtggtg cgccacaccg acgacggtga ccgcgccacc gccgcactgt 319741 ttgcgctgga cagtcccgca cgggtcgcgg agttcaccga tcggctggcg cgtcagctcc 319801 gtgaggctcc cctgcgggca acgtgagacg cggtgccgcc gcgggcgata cgctccgacc 319861 gtcaacgagg aggacggcca tgtggtttgc attggtgaac ccggagatgc tggccgcggc 319921 ggcgacagac ttgggcggca tcaggtcagg gatcagcgcc gcctatgcgc gtcctctgcg 319981 gtgacctggc tggtagctta ggcacgtctt tatcgacacc gggtgctgcc agagaactcg 320041 agacgcggca caggtcggca ccatgaggcg gcgtgcaatg acgaagatgg acgaggctag 320101 caatccgtgc ggcggggaca tcgaagctga gatgtgccag ttgatgcgcg agcaaccacc 320161 cgccgaaggc gtcgtcgatc gtgtcgcgct gcaacgccat cgaaacgttg cgttgatcac 320221 gctgagccat ccgcaggcgc agaacgcact caacctggcg agctggcgtc ggctgaagcg 320281 gctgctggac gatctcgccg gcgaatcggg gctgcgggcg gtggtgctgc ggggcgccgg 320341 tgacaaggcg ttcgccgcgg gtgccgacat caaggagttt ccgaacaccc gcatgagcgc 320401 cgcggacgcc gcggagtaca acgagagcct ggccgtctgc ctgagggcgt tgaccacgat 320461 gccgatccca gtcatcgcgg cggtccgggg gctcgccgtc ggtggcggct gtgagctggc 320521 gacggcctgc gatgtgtgca tcgcgaccga cgacgcgcgc ttcggcatcc cgctgggcaa 320581 gctcggcgtc acgacgggct tcaccgaggc ggacaccgtc gcgcgcctca tcggtccggc 320641 ggcgctgaag tatctgttgt tcagcggaga actgatcggc attgaggaag ccgcccgctg 320701 gtgattggtg caaaaggtcg tcgcaccaca ggatttggcg gccgcgacgg ccaaactggt 320761 cggccaggtc tgtcggcaat ccgcggtgac catgcgtgcg gcgaaggtgg tcgccaacat 320821 gcacggccga gcgctgaccg gcgccgacac cgatgcgctg atccggttcg gtgtcgaagc 320881 ctacgagggg gcggacctac gcgaaggggt ggcggccttc agccagggac gcccacccaa 320941 atttgatgat tagcgccatg accgatgctg acagtgcggt ccctccccga ctcgacgagg 321001 acgcgatctc gaaactcgag ctgaccgagg tcgccgacct gatccgcacc cggcaactga 321061 cgtcggcaga agtgaccgag tcgacgctgc ggcgtatcga aaggcttgac ccccagctga 321121 agagctacgc cttcgtcatg ccggaaactg cgctagcggc ggcacgtgcc gccgacgccg 321181 acatcgcgcg cggccactac gagggtgtcc tgcacggcgt accgatcggc gtgaaggatc 321241 tctgctacac ggtcgacgcc ccgaccgcgg ccggcaccac catctttcgt gactttcgcc 321301 cggcatacga cgcgacggtt gtcgcgaggt tgcgcgcggc cggcgcggtg atcatcggca 321361 agctggccat gacggagggg gcctatctcg gctatcaccc cagtctgccg accccggtca 321421 atccctggga cccgacagcg tgggcgggcg tgtcctcgag cggctgcggc gtggccaccg 321481 cggcgggatt gtgcttcggc tcgatcgggt cggacaccgg ggggtcgatt cgctttccga 321541 cgagcatgtg cggcgtcacc gggatcaaac cgacgtgggg ccgggtcagc cgtcacggcg 321601 tcgtcgaact tgcggcaagc tacgaccacg tcgggccgat cacccgtagc gctcacgatg 321661 cggcggtatt gctcagtgtc atagcgggat ccgatatcca cgatccctcg tgctcggcgg 321721 agcccgttcc ggactatgcc gccgacctcg ccttgacacg gattccgcgt gtcggggtgg 321781 actggtcgca gacgacgtcg tttgacgagg acaccacggc gatgctggcc gatgtcgtca 321841 aaacgctcga cgacatcgga tggcccgtca tcgacgtcaa gctgcccgcg cttgcgccga 321901 tggtggcagc gttcggaaaa atgcgcgcgg tcgaaacggc gatcgcgcat gccgacacct 321961 acccggcgcg cgccgacgag tacgggccga tcatgcgcgc aatgatcgac gccggacaca 322021 ggctggctgc ggtggaatat cagacgctga ccgagcggcg tctggaattc acgcgatcgc 322081 tgcgtcgcgt gttccacgac gtggacatcc tgctgatgcc cagcgccgga attgcctcgc 322141 ccacactgga aaccatgcgc gggctcggac aagacccgga gctgaccgcc agactggcga 322201 tgccgacagc accgttcaac gtcagcggta atcccgcgat atgcctaccg gcgggaacga 322261 cggcgcgcgg aacgccgctc ggcgtccagt tcatcggccg tgaattcgac gagcacttgc 322321 tcgtccgagc cggccacgca tttcagcaag tcaccgggta tcatcgccga cgcccgccgg 322381 tgtgaaaaac cctcggccgc aaaaggcttg cgaatgtcgc accgaaggtc gcggcgaatc 322441 gccttactgg tatgtttacg aacacaatct gtggccatca agggaggacg cgttgagcat 322501 tagcgcggtt gttttcgacc gtgacggtgt gctcaccagc tttgactgga cacgtgccga 322561 ggaggatgtg cggcgaatca cgggcctacc attggaggag atcgaacgcc gctggggtgg 322621 gtggctcaac ggattgacta tcgacgacgc gttcgttgaa acccagccaa ttagcgagtt 322681 cctctcgagc ctggcgcgcg agctcgagct cggttcgaag gcaagagacg agctagtgcg 322741 cctcgactac atggcgttcg cccagggata tccagacgcg cgtccagccc ttgaagaagc 322801 ccggcgccgt ggcctcaagg tcggtgttct cacaaacaac agcctgttgg tcagcgcccg 322861 cagcctcctt cagtgcgccg ctctgcacga cctcgtcgac gtcgtgctga gttcgcagat 322921 gatcggagct gccaagcctg acccgcgggc ctatcaagcg atcgcggaag ccctcggcgt 322981 ctcgacaacg tcatgcctgt tcttcgacga catcgccgac tgggttgagg gcgcacggtg 323041 cgcgggcatg cgcgcgtacc tcgtggaccg ttccggacaa actcgcgacg gcgtcgttcg 323101 cgatttgtcc agccttggag cgatcctgga cggcgcggga ccatgaccga acgtgacgag 323161 ccggacatcg ccgacaggga cgcctcattg gttactctca tcgaccagcc gcagtgcact 323221 taggatggca gccttaacta ccgtcgccga gcagtaaagt gtcttggcaa tccacaacgg 323281 cgcgtatggc ggttcgcagt gttgcgatag ccacccaccc gcgcgactga tctgcgccga 323341 caaggatgtg ccgctgtgcc tctgccaatg cgccagagct tgaatgcaat atgctgtctc 323401 ttccgcagtc gcttggccgt cgaaaaatcc ccacgagcca tcgggcctct gcgtattaag 323461 aatccaccca atcgcatctg agcatagggc atcatcatag ttactggcag cacatatcag 323521 atgcgcagtc gtataatatg ccgatcggtg ccacttatcc cgccagcaga accgtccagg 323581 ctccttgctt gatcggatga attccagaac ctttcgtact cgtggatgac atttgtcgta 323641 gcccgcctgc ttcaacgcac cgagcacgtg gacgttcgtc gatatcgagg ggccgacttc 323701 gtgaaagtag gtacggaacc aatcggcgtc ttcgaattgt aatacggctc cgatatccgg 323761 cgaccgtcca aacttcgaca aaacatcgta ggccacactt gtggtgtcac aatcttccaa 323821 ggtggaattt cctgtccacc ccacacctcg accacggacc caatgttgtt cgacatggtc 323881 aagatagggt aggtacgtac gaacgatctc aggatcggac aaatcaatat ccgtacgcga 323941 gagattccat agagaccaaa caatttcaaa aatctcggct tgatagaagg ccggcgcacc 324001 gccatcgccg gcttgaatta tcgatgagat gtacgccaag gcccgcttgt ctcctggttt 324061 aacatgtaac gcgaagtagg ctgacgctga tggcgaatac ttgaccgatc catttgtctc 324121 ctgcaagtta tcgacatcca acataccgac accgtcttgg ccggccagtt ctacggagaa 324181 agctgcggtg atatgtttat tgattttgct tccgccgagt tttctcaact tctgctcacg 324241 cactccgaca agctcgccga ggatggattc ctcgtggcaa atggcaaggc caagtcgcgc 324301 cgcctcagcc atcagcgtag gtgcgattaa ctcaaacccg acggttgcgt cttttatatc 324361 aagttgaggg ccttcgaaag cacccgaggt aaggttcttc agggctagca agcctttttc 324421 aacttgcgct gcgcgcctcc gacgatgctt attcgacgtg aggctgatca tggccgccaa 324481 agtggagagc agtcgatctt cgtagcagaa agggaactcg gctccccatg agccgtcagg 324541 aagctggcgc tcgcaaagcc agttgagggc gaggtcgctt agctcatcat cgagctggcc 324601 cagcttcgcg acccacgcgg tgtcataggc tgtgctcgag atgccgttgc ctagtgccgc 324661 tttcgctagc agagtcctga aagtctccat accatcagcc ctccgcgaac cagattccat 324721 catgaacaca acccacaccg aaaactctgt caggctgggc tcgatatctg ttgcgcagta 324781 cattgagctg atcggccgac atcgctgaat agtcaggttt gggccggaaa tgacggagat 324841 agatatgatc gtacaagatc ctccggagcg ttgtttcggt catatagtat gagggagcaa 324901 cggtgaagta tagactcgtt tttcctgagc tgagcagcgg aaaatcgaaa gtgctgaaac 324961 gcccaaatcc gatgaacatg tcagccttgt caacatactc gccgtaataa ccttcgataa 325021 tctctctccg cgtgggaggt ttaccatgcg tttcgttcca cgagatagaa aactgcgcaa 325081 cagactcagc cgcatcgttg ccaaaaacac cgaagcatag tctgtgttca gtgttggatg 325141 acgtagagat tgttaggtca tcgaatgact tgacaacggc tgccccttgc gcggtcgaag 325201 gcaatctttt cttataatca ccataaaaaa gaacgtggac ctcgtgttct ttatagaacg 325261 acagaatttc ctcgtcgttg gcaagcaagg ccatcccttc gagcgcctgt acgatatatc 325321 gatcaccacg atccagaaga tcgtcgctaa agattggcga gattactgtt tcgatgccgt 325381 gctcgaagag catcttcaga atacgaattg attgacgcaa ggcggcctgc tgataatcgt 325441 cgtactgcgg attacattcg aggtgaaacc agcggcgtgt gccatcgaag ggaaagacgg 325501 ataccttcgg tccacggcaa cgtacaatct ctgctacgga tactagagga agatccaaga 325561 attctttttc gctaaccaag ttcatgcttc ctcttaataa ctatcgccgg aatcaggatg 325621 gtcttcgggt ccagggactt catgtagtgc gttaagtagt gatttgcatc ttatgcggat 325681 tgcggggccg gtgagtccgt ggctggaaag gatgtggtcg cggctggcgt ggggaatgta 325741 ggccggtggc agtcccagtg tgtaggtgcg cgtccgcggg tgtgtccgcc cgatgtggtg 325801 gctaaggtgc gcgccgattc ccacgtcggc aatcgcatct tcgacacaca cggtgatccg 325861 atggcggcca gccagctcgg tcagtgccgg gctgattggc cagacccatt gtggatcaac 325921 gactgtcacc ccgatctgct cctcgctgag gcaccgggcg gcgtccatgc atggtcgact 325981 catggcaccc actgcgacca agagcacgtc gggtcgccaa tgcggtggtg gtgtatgcaa 326041 gacgtcgagg ccaccgatgg tgtgttcggc cgtgatcggt tcgcccggcg cccctttggg 326101 gaaacgcacg gcggtgggag ccgcggtcgc gatcgcggta cgcaactgtt gtcgtagccg 326161 aggcgcgtcg cgcggacagg cgatctgaaa cccgggcacg caggccagca gcgccagatc 326221 ccacaaaccg tgatggctgg gtccgtcggg cccggttacc ccagcccggt ccagcaccag 326281 cgtcacgggt aaccggtgca gcccgatgtc gaacagaagt tggtcaaagg cgcggtgcag 326341 aaacgtcgag tacaccgcga caacgggatg ggttcccgcg gcagctagcc cggccgcgct 326401 ggccaacagg tgttgttcgg cgatgcccga atcgaacacc cgatgcgggt atcgcctcga 326461 cagcgcgcct agaccagtgg gcagacgcat cgccgcggtc agcccgacga cgtcggatcg 326521 gtcgtcagca atgcgcgcga tttcgtcctc gaacacgtcg gtccagctcc gctgactggg 326581 tgtgctagcg aggccggtgg caatgtcgac caccccgcag gcgtgcatat ggtccctctc 326641 gtcagcttcg gctggaggat aaccccggcc cttactagtc actgcgtgaa caacaacggg 326701 cctagctgcc gcggccgctt ttcgtagaac cgcgcacgtg tcggggatgt tgtgcccatc 326761 gaccggaccg atgtaggtaa atcccatgtt ctcaaagagg ttcggccctc ggggtgtgcc 326821 gacgcgaagt tcttctaggt gtgccgcaag agccccagcg gtggggtcgt aggagcggcc 326881 attgtcattg agcacgacga tcacgggccg ggtagcggca ccgaggttgt tcaggccctc 326941 ccatgccacg cccccggtga gggcgccatc accgatcacc gcgatgacac gtcggtcgca 327001 ttgcccctgc agggccaatg ctttggcgat gccgtccacc caggcgaggc tgaccgaggc 327061 atgggagttc tcgacccagt catgtggcga ttcatggcgg ttgggatacc ccgatagacc 327121 atcggcctgg cgcagcgtgg cgaagtcttt accgcggccg gtgagcagct tgtgcggata 327181 ggtttggtgc ccggtgtcga acaccgatgt cgtgtggcga ggtgaacacc cgatgcaatg 327241 cgatggtcag ctctaccatg ccaagtcccg cgccgagatg gccaccggta gccgtcactg 327301 tttctatgag ccgccgacgc atctgcacgg ccagctctgg cagctggctt tcgggcaatg 327361 cctgcacatc gcaaggtccg ccgatcgcgg taattgaacc gccccggtga gtccggagac 327421 tctctgatct gagacctcag ccggcggctg gtctctggcg ttgagcgtag taggcagcct 327481 cgagttcgac cggcgggacg tcgccgcagt actggtagag gcggcgatgg ttgaaccagt 327541 cgacccagcg cgcggtggcc aactcgacat cctcgatgga ccgccagggc ttgccgggtt 327601 tgatcagctc ggtcttgtat aggccgttga tcgtctcggc tagtgcattg tcataggagc 327661 ttccgaccgc tccgaccgac ggttggatgc ctgcctcggc gagccgctcg ctgaaccgga 327721 tcgatgtgta ctgagatccc ctatccgtat ggtggataac gtctttcagg tcgagtacgc 327781 cttcttgttg gcgggtccag atggcttgct cgatcgcgtc gaggaccatg gaggtggcca 327841 tcgtggaagc gacccgccag cccaggatcc tgcgagcgta ggcgtcggtg acaaaggcca 327901 cgtaggcgaa ccctgcccag gtcgacacat aggtgaggtc tgctacccac agccggttag 327961 gtgctggtgg tccgaagcgg cgctggacga gatcggcggg acgggctgtg gccggatcag 328021 cgatcgtggt cctgcgggct ttgccgcggg tggtcccgga caggccgagt ttggtcatca 328081 gccgttcgac ggtgcatctg gccacctcga tgccctcacg gttcagggtt agccacactt 328141 tgcgggcacc gtaaacaccg tagttggcgg cgtggacgcg gctgatgtgc tccttgagtt 328201 cgccatcgcg cagctcgcgg cggctgggct cccggttgat gtggtcgtag taggtcgatg 328261 gggcgatcgg cacacccagc tcggtcagct gtgtgcagat cgactcgaca ccccaccgca 328321 aaccatcggg gccctcgcgg tggccctgat gatcggcgat gaaccgggta attagcgtgc 328381 tggccggtcg agctcggccg cgaagaaagc cgacgcggtc tttaaaatcg cgttcgccct 328441 tcgcaattcg gcgttgtccc gccgcaagcg cttcagctca gcggattctt cggtcgtggt 328501 cccgggccgt gcgccggcat cgacctgcgc ctggcgcacc cacttacgca ccgtctccgc 328561 gcagccaaca ccaagtagac gggcgacctc actgatcgct gcccactccg aatcgtgctg 328621 accgcggatc tctgcgacca tccgcaccgc ccgctcacgc agctccggcg ggtacctcct 328681 cgatgaacca cctgacatga ccccatcctt tccaagaact ggagtctccg gacatgccgg 328741 ggcggttcaa atcaagtccc cgcgtccgtt gcgaatcgtg gttgtcattg cgcgcgaacc 328801 tgtttgggaa ggccgaatcg caccgtctcg gtcgctatcg agcgttccac cacggtgatc 328861 gaggcgtatc cgcgaagtgc atcaatcacc tgccccacca gtcgtggcgg cgcggaggct 328921 cccgcggtga caccgatcgt cgagaccgac gacagccatt cgggctcaat gtcatcaggc 328981 ccgtcaatca agtaggccgg cgtcccactt cgctgcgcca actcgaccag acgccgcgaa 329041 ttcgacgaat tgcacgagcc aatcaccaac acaacgtcac attcaccgac catcgattgc 329101 agcgcacgct gtctgttcgt ggtggcatag cagatgtctt cagagggggg ttggcccaac 329161 gtcggaaacc tcgcgcgcag cgcatcaatg acatcggcag tttcatcaag tgccagggtt 329221 gtctgggtca gatacgatag ctgggtaccc tcgggcaggt tcaacgctgc cacatcagcg 329281 ggtgtctgca ccaataatgt tgaccgcgga gcgacgccaa gcgtgccttc ggtctcctca 329341 tgtccggcgt gcccgatgaa gaccaccgtg tcaccgcgcg cggcaaaccg tgcggcttca 329401 gcgtggactt tcgccaccag tgggcaggtc gcgtcgacga cctgcagtcc ccgctcatca 329461 gcgcccgcgc gcaccgccgg ggaaacccca tgcgcggaga acaccacgac cgcccccggc 329521 ggcggcggat cgggaatctc gtcgagatcc tcgacgaaca ctgctccccg gtcccgcaac 329581 tcggcaacca caacagtgtt gtgcacgatt tgcttgcgca catacaccgg gccttcggcc 329641 acgtcaagca ctcgcttgac cgtctcgata gcacgctcta caccggcgca aaacgaccgc 329701 ggcgacgcca acagcaccgt gacttcaccc gaagcgtatc cctgtgcgac cggtcccacg 329761 aacacctcag ccatcagcac tcccggcgac atatcagttg cgacaacgcg atcaggtctg 329821 gggatcgcac cgcatcgggc agtgccgcaa tagcagcctg gatgcgttca tcggcgcatc 329881 gctgcgccac atgaccaccc ccggccacct tgacaagcgc ggtagcccgc tcgacatcgc 329941 ttgctgtcat tgcggcaggt gcttgataga gggccgccaa ttcggtcgcc gcttcggatc 330001 gcgagttcag ggcggcaaca actggcagtg tcgccttacg tcgggcaagg tcgttgccga 330061 ccggctttcc cgtcacacca gggtcacccc agatgccgat cagatcgtcg acgcattgaa 330121 acgcaagacc caactcatgg ccaaaacgct ccaacgcagc aatcgtcgcg tcgtctgcat 330181 tggccactaa agctcccaga gcgcaacaac aaccggtcag ggcggccgtc ttgcccgcgg 330241 ccatccgcag atagtcatcg actgtaactt cgggctgtcc ctccaataaa caatcctcaa 330301 actggccgat acacaagtcc aggcacgaca tctgcaatcg ccttatcgcc ctgaccgcca 330361 cacactcgtc ggtcaggccg gtcagtatcc gaacggccgt ggcgtgcaac gcatctccca 330421 acaggatcgc gacgcccaca ccccacacac tccataccgt cggccgtccc ctgcgagtcg 330481 catccccatc catcacatcg tcatgcaaca acgtgaagtt gtgcaccaac tccacagccg 330541 ccgacaccgg agtagcatca ccgacatcac caccgcaagc cgcggccgcc gcgtagacaa 330601 gggcggcgcg aaaatacttg cccgacgatc ctgccgctgt ggatcgatcg gcgttccacc 330661 agccaaggtg atatcccgcc atcgtcgcca acggctcgcg catcgactca atggcccgat 330721 gcagcacagg gccacaatcc gctcgagccc gttctaacaa tgctttccca aggtcagcag 330781 ggacactccc cagaaaagcc gcatccagag tcaatacgcc tcccattctt aacctcaccg 330841 gagcaacagt gagtcgctat tttcagcgaa cgagcaatcg gcgatattgc ttcacttcgg 330901 agatacccaa atatttcaaa tatcaacgca acatgtacct atgcccgtcg accaacacga 330961 ccatcagggt tgttagcaat gatctcggaa ttcgagttgt ccagacgccc cgggtcatcc 331021 actacagaaa gacacgcata ccctgcggcg acctatactt cccatcacgg cgggtaggtt 331081 gccttcgaca atactgcaac attcaattgc ctggcctttc tcggagtatc ttgcggactt 331141 gaagctcaca catcggccgg cgtcgaacgc ctcacgctgc agagcagttt agtggatttc 331201 atcagcatcg gatatgcata attgaaacca cagcactttc ataaacagtg tccagatgat 331261 ttacacctaa tttgggcggc gaatgctacg caatggtggt gcgcttccca agggagcaca 331321 acgcgaagct aaagcagttg cacgccgaga ccgagccgaa aggtcgccct gcggggaagg 331381 cggccacggg agaattgtga gctcggcggt cgaccacgac gtacccgcca cgccgtagta 331441 atgggcattt gtacatgtac attcgcacac aaggagaggt cttgacgtat ctattccctc 331501 tctgcgcgat cgcggcggag gcggcggcaa ccagcctgtt caagggcagt ttcggggact 331561 ttcgcgtctg ctcgccgggt cacgacgggg cgatcacggc catgccgagc gtcttggcgg 331621 cgtcgcgcat ccggtcgtcg taggtgcaca accggcccag atcgacgccg agccgctgcg 331681 ccgtcgccaa gtggatggca tcgagcgtgc gcagctcgaa tggcagcagc ccaccagcga 331741 gatcgaggac gcgcttgtcg acgcgcagca gatcgagatg agccagcgcc cggcggccgg 331801 ctttccgcgc tgattcaccc ttgtcaagca gggcccgcat gacctccgcg cgcgcaaggg 331861 cactcgacac tcgcgggtgg cgggtgcgaa ggtagcggcg cagcgcgtcc gactctggct 331921 cgcgaaccgc gagcttgacg atcgcggacg agtcgagata gatggccgcc atcaacgctc 331981 gtgctcacgc aggcgcgcaa gcgtcaccga cggcagctcg acgcccgcgt cgaggtcgag 332041 cggttcgggc agatcaacga cgtcgagcgt ggcacgctcg atctcgccgc ttgccagcag 332101 ctgctcgtat ggaccgccct gcggcagcgg cgagagcagg gcgacgggcc ggccgcggtc 332161 ggtgatctcg atcgtctcgc cggcctcgac tcggcgcagc agctcgctgg cccgctgccg 332221 cagcgcacgc acccccaccg aggtcattgt gctaactgta gcacaagcgg tcggcgtcat 332281 gggccgacgt tcgactcgcg caggctttaa gtaacgtcgg tgttaattac taggacctga 332341 aaaagtcggc gcgttgttcc tcggttggtt ggcgctgagc tgggaggatg gcctcaatgc 332401 ccttgttgcg gaagggattg aggccatcgt gtttcgtact gtaggcgatc aggcatcgtt 332461 gtgggaatcc gtgctgcccg aggagttgcg gcggctgccc gaagagctgg cccgggtgga 332521 tgcgctgctc gatgattcgg cgttcttctg cccgtttgtg ccgttcttcg acccgcggat 332581 gggtcggccg tccataccga tggagaccta tttgcggttg atgttcttga agttccgtta 332641 ccggttgggc tatgagtcgc tgtgtcggga ggtcaccgat tcgatcacct ggcggcggtt 332701 ctgccgtatt ccgttggagg gatcggtgcc gcacccaacc acgttgatga agctgaccac 332761 gcgctgcggt gaggatgcgg tggccgggct caatgaggcg ctgctggcca aggcggccag 332821 cgaaaagctg ttgcgcacca acaaggtccg tgccgacacc accgtggtgg agggcgatgt 332881 gggctatccc accgacactg gactgctcgc caaggcggtc ggctcgatgg cgcgcaccgt 332941 ggcgcggatc aaagccgcgg acgcgggatc ggcgccgctc ggtgggtcgt cgggcccgcg 333001 cgatcgcctc caagctgcgg ttacgcggcg cgcagcaacg cgatcaggcg caggccttcg 333061 tgcgccggat caccggggag ctagccggga tcgccgagca ggcgctgacc gaggctgccg 333121 cggtggtacg taacgcccaa cgtgcggtgc gccgcgccag tgggcggcgc aaagcctggc 333181 tacgccaggc catcaaccat ctcgagaagc tgatcggacg caccgagcgg gtggtggacc 333241 aggcccgtag ccggctggcc ggggtaatgc ccgactcaag cagccgcctg gtcagtctcc 333301 acgatgccga cgctcgcccg atccgcaagg gacgattggg caagccggtc gagttcggct 333361 acaaggccca ggtcgtcgac aacgccgacg gtgtcatcct ggaccacagc gtcgagctcg 333421 gaaaccccgc agatgcaccg caattggcac ccgccatcga acggatcagc cgccgcaccg 333481 gacgcccacc acgggcagtg accgctgatc ggggctgcgg agacgcatcg gtcgaagatg 333541 atctccacca gctcggggtg cgcaacgtgg ccatcccacg caagagcaaa cccagcgcca 333601 cccgccgcgc attcgaacac cgacgggcat tccgcgacaa gatcaaatgg cgaaccggat 333661 ccgaaggacg catcaaccac ctcaagcgca gctacggctg gaaccgcacc gaactcaccg 333721 gcatcaccgg cgcccgaacc tggtgcggac acggcgtctt cgcccacaac ctcgtcaaga 333781 tcagcaccct ggcagcgtga cagacacccg cgcccacccc gaccacgcca cgcaggtcgc 333841 ccagcccgcc gccgtcaatg caaccgcgac tttttcaggt cttagtaatt agtggccgcc 333901 gctttgggtc caccggggcc ctgcggcgaa acaccagacg tgatgccgtg atcggcgata 333961 cccttcgacc cattgaaggg agaacagcca tgtcgtttgt gatcgcgaac cccgagatgc 334021 tggcagcggc ggcgaccgat ttggccggca tccggtcggc gatcagcgcc gcgaccgcgg 334081 cggccgcggc cccgacgatc caggttgccg cggccggcgc cgacgaggtg tcgctggcca 334141 tctcggcgct gtttggccag cacgcccagg cctatcaggc gctcagcgcc caggcgacga 334201 tctttcacga ccagttcgtg caggccctga cctccggcgg caacctgtat gcggccgccg 334261 agagccacac cgtcgagcag atggtgctca acgcgatcaa cgcgcccacc cagacactgt 334321 tcggccgccc gctgatcggc gacggcgcca acgggaccgc ggagaacccg gacggccaaa 334381 acggcggcct gctgttcggc aacggcggca acggctttac ccagacgacc gccggggtgg 334441 ccggcggcaa cggcggcagc gcggggttga tcggcaacgg cggggccggc ggcggcggcg 334501 gggccggcgc cgccggcggc ctcggcggca acggcgggtg gctgtacggc aacggcgggg 334561 ccggcggcat cgggggcgcg ggcaccggaa ccggtggtca cggcggggcc ggcggggccg 334621 gcggccgggc ctggctgtgg ggcaccggcg gggccggcgg agccggcggt gacggcggct 334681 ggttgttcgg cgacggcggg gccggcggca ccggcggcaa cggcggcagc ggctttaaca 334741 gcttgacctc ttcggtcggc ggcgccggcg gggccggtgg gcacgccggg ctgttcggcg 334801 ccggcgggac cggcgggacc ggcggcatcg gcgggcaaaa caccgagacc ggcccggccg 334861 ccagcaacgg cggcgcgggc ggcgccggtg gcggcggcgg gtacctggtc ggcgatggcg 334921 gcgccggcgg gaccggcggg gccggcggga agaattccag cggtggcgcc accctcaccg 334981 ggggcaccgg agggaccggc ggggccggcg gggcggccgg gtggctctac ggcagcggcg 335041 gcgccggcgg tgccggcggc gccggcgggc tcaacaacgc cggtggtgcc accggcggca 335101 ccggcggtac cggcggagcc ggcggctctg gagcgtggct gtacggcaac ggcggggccg 335161 ccggggccgg cggcaacggc ggcaacaata ccagcgccgg caccggtggt gtcggggcta 335221 gcggcgggac cggcggaaac gccgggctga tcggcgccgg cggccacggc ggggccggcg 335281 gcgccggcgg aaaccaaacc ggtggcgtgg gcaacggcgg ggccggcggg aacggcggcg 335341 ccggcggggc cggtggtcag ctgtacggca acggcgggga cggcggcaac ggcggggccg 335401 gcggggccaa catcgccggc ggcaatggca gcgacggcgg cgccgccggc cacggcgggg 335461 ccggcgggag cgcccggctg atcggagccg gcggccacgg cggggacggc ggcgccggcg 335521 ggaacaccgc cggcagaagg gccgacgcga tcgccggcac cggcggggac ggcggcaacg 335581 gcgggaatgg cggcttgcta agcggcaacg ccggggccgg cggccacggc ggggcgggcg 335641 ggagcagcac cgcgaccacc accaccggaa cacccccaac gggtgcaacg ggcggcaatg 335701 gcggcaacgg cggggccggc ggcacggccg ggtttaccgg cagcggcggc atcggcggca 335761 acggcggggc cggcggcacc ggcggtaacg ccggtgtcgc cttgtcggtt ggcagcacgg 335821 gcggactggg cggtaacggc ggcagcgggg gcctcggcgg cggcggcggg tcgctcttcg 335881 gcaatggcgg ggccggcggt gtcggcgcaa ccggcggaaa cggcggaagc ggtatcgggc 335941 ccgccagcgt gggtggcaac ggcggcaagg gcggcgttgg tgcggccggc gggcttgccg 336001 ggcagatcgg caacggcggt agtggtgggt ccggcggtgc cgggggcaac ggcgggaccg 336061 gcgataccgc cggcaacggt ggcaatggtg gtgccggcgc ggtcggcggc aacgcccagc 336121 tcatcggcaa cggcggcaac ggcggtggcg gcgggaacgg cggaaccggc gccgacggca 336181 cctaaggccc gcgagcagac gcaaaatcgc ccaatttcgt gccgaattgg gcgattttgc 336241 gtctgctcgg cgcagctaac ccgccacgta ctccaccgcg ccgtcgtcga gcaccacccg 336301 ggcctcggcg ccgtcggagc cggccacctc ggtgcggaac accgcccggc ccggctcggt 336361 gcgccagatc accgtcgaca gcgtctcgcc gggaaacacc ggcttggtga accgcgcggc 336421 gatcgaggtg atgttggccg ccacaccgcc gccaagctcg gccaccagcg cccggcccgc 336481 caccccgtag gtgcacaacc cgtgcaggat cggcttggga aacccggcca gctgcgtggc 336541 gaaccagggg tcgctgtgca gcgggttgcg gtcaccggag agccggtaga tcagcgcctg 336601 gtcctcacgg gtcggcatat cgattcgggc gtcggggtgg cggtccggaa attccggcgc 336661 ggccggccgc tcaccccgcg ctcctccgaa acccccctga ccccgaagca ccaacgtggt 336721 aagcgtttcg gcaaccaacg aacccgattc cgggtcgcaa ccgcggccgc gcagcacaac 336781 gatggcgttc ttgccctccc ccttgtcctg gatgtcggcg acctcggtga ccaccgacag 336841 ttttcccgcc gccggcagcg gcgcatgcag ccggatgccc tgggagccgt gtagcagcgc 336901 cgccgggttg aatgttccca cctttgcggc cgcaccaaac gccggacagc aaatcaccgc 336961 atacgtcggc aacacttgct ggtcgatgcc gtggctgttc tccgtggtga acgccagatc 337021 tccggtcccg gcgcccaccc cgatcgcgta aagcagcgtg tcccggtcgg tccactcgaa 337081 caacatcggc tcggtcactg cacctatgga gttcggatca atcgccatgc aactctcctc 337141 ccggttggaa aatcatcgca agcccttccc ccggacggta tcgacagggc aggctatcgc 337201 catggcgaag cgcaccccgg tccggaaggc ctgcacagtt ctagccgtgc tcgccgcgac 337261 gctactcctc ggcgcctgcg gcggtcccac gcagccacgc agcatcacct tgacctttat 337321 ccgcaacgcg caatcccagg ccaacgccga cgggatcatc gacaccgaca tgcccggttc 337381 cggcctcagc gccgacggca aagcagaggc gcagcaggtc gcgcaccagg tttcccgcag 337441 agatgtcgac agcatctatt cctcccccat ggcggccgac cagcagaccg ccgggccgtt 337501 ggccggcgaa cttggcaagc aagtcgagat tcttccgggc ctgcaagcga tcaacgccgg 337561 ctggttcaac ggcaaacccg aatcaatggc caactcaaca tatatgctgg caccggcaga 337621 ctggctggcc ggcgatgttc acaacactat tccggggtcg atcagcggca ccgaattcaa 337681 ttcccagttc agcgccgccg tccgcaagat ctacgacagc ggccacaata cgccggtcgt 337741 gttctcgcag ggggtagcga tcatgatctg gacgctgatg aacgcacgaa actctaggga 337801 cagcctgctg accacccatc cactgcccaa catcggccgc gtggtgatca ccggcaaccc 337861 agtgaccggc tggaggctgg tggaatggga cggcatccgt aacttcacct gaccgcgcgg 337921 ttgacgctta ccgccgctga ccgccacgat tgaccgcatg cggtacgtcg ttaccggcgg 337981 taccgggttt atcgggcgcc acgtggtatc ccgtctcctg gacggccgac ccgaggcacg 338041 gctgtgggcg ctggttcgcc gccagtcgtt aagccgcttc gagcgcctcg ccggccagtg 338101 gggtgaccgg gtaagaccgc tggtcggtga tctcacggag ctcgaactgt ccgagcggac 338161 catcgccgag ctaggcgata tcgaccatgt gctgcactgt gcggcggtac acgacaccac 338221 ctgggccgac gccacccgcg ccgtcatcga gctggcggca cgccttgacg ccacgtttca 338281 tcacgtgtcg tcgatcgcgg tggccggaga cttcgccggc cactacaccg aggccgactt 338341 cgacgtcggc cagcgcctac cgaccccgta tcatcggatg acattcgagg ccgaacggct 338401 ggtgcgctcc acgcccggcc tgcgctatcg catctaccgc ccggcggtgg tggtgggtga 338461 ttcgcgcacc ggcgagatgg acacgatcga cggaccctac tacttgttcg gggtgctggc 338521 caagctggcg gtgttgccgt cgttcacccc gatgctgctg ccggacattg ggcgcaccaa 338581 catcgtgccg gtcgactatg tggccgacgc gctggtggcg ctcatgcacg ccgacggccg 338641 ggatgggcag acgtttcatt tgaccgcgcc gacagcaatc ggactgcgcg gcatctaccg 338701 cgggatcgcc ggcgcggccg gactgccccc gctactcggg acgctgcccg gctttgtggc 338761 cgcaccggtg ctcaacgcgc gcggccgcgc caaggtgctg cgcaacatgg cggccaccca 338821 actgggaatt cccgccgaga ttttcgacgt cgtcggctgc gcgcccacgt tcacgtccga 338881 cacaacccgg gaagcgttgc gcggcaccgg cattcacgtc cccgaattcg ccacctacgc 338941 gcccgggctg tggcggtatt gggccgagca cctcgacccc gaccgcgcgc gtcgcaacga 339001 tccgctgctg ggccgccacg tcatcatcac cggtgcgtcc agcggcatcg ggagggcatc 339061 ggcgatcgcc gtcgccaaac ggggtgcgac ggtattcgcg ctggcccgca acggcaacgc 339121 gctagatgag ctggtcaccg agatccgcgc ccatggcggt caggcgcacg cattcacctg 339181 cgacgtcacc gattccgcgt cggtggagca caccgtcaag gacatcctgg gccgtttcga 339241 ccacgtggac tacctggtga acaacgccgg ccggtcgata cgccgctcgg tggtcaactc 339301 caccgaccgg ctgcacgact acgagcgggt gatggcggtc aactacttcg gcgcggtgcg 339361 catggtgctg gcgctgctgc cgcattggcg cgagcgccgg ttcggccacg tcgtcaacgt 339421 ctccagcgcc ggcgtgcagg cccgcaatcc caagtacagc tcgtatctgc ccaccaaggc 339481 cgcgctggac gcgttcgccg acgtggtcgc ctccgagacg ctgtccgacc acatcacgtt 339541 caccaacatc catatgccgc tggtggccac cccgatgatc gtgccgtcgc ggcggctcaa 339601 cccggtgcgc gcgatcagcg ccgaacgcgc ggcggcgatg gtgatccgcg gactcgtgga 339661 aaagccggcg cgcatcgaca ctccgttggg tacgctcgcc gaagccggca actacgtcgc 339721 gccacggctg tcgcgccgaa ttctgcacca gctctatctg ggctatcccg attcagctgc 339781 agcgcagggg atttcgcgtc cagacgcgga ccgcccaccg gcgccgcggc gtccccggcg 339841 atccgcccgc gcgggagtcc cgaggccgct caggcgcttg gggcgactgg tgcccggtgt 339901 gcattggtag tcacttctgg caggtgaact ggttgacgtc gatgtatccg atgcgaaaca 339961 tctcggcgca gccggtgagg tacttcatat accgctcgta gacttcctcg gattgcagcg 340021 cgatggcctg gcccttgttg gcctgcaacg ccgcggacca gaggtcgagg gttttcgcat 340081 agtgcggctg caacgattga actctggtga cggtgaagcc gtttgcgctg gcacactcct 340141 gcaccatcgg tatcgagggc agccgcccac ccggaaagat ctcggtcaca atgaatttca 340201 ggaaacgagc gaaggtgaac gacatgggca ggccgcgttc gtggatctct ttcggatgca 340261 acccggtgat ggtgtgcagc agcatgaccc cgtcagcggg cagcaggcga tgcgccaggc 340321 tgaagaacgc gtcgtagcgc tcgtgaccga aatgttcgaa agcaccgatg ctgacgatgc 340381 ggtcgacggg ctcgtcaaac tgttcccagc cggccagcag aacgcgtttg gagcgtagat 340441 tttcggagtt ggcgaccagc tgctgaacgt ggttggcctg gtttttgctc agggtcagac 340501 cgacgacgtt gacgtcgtat ttttccaccg cgcgcatcat ggtggcgccc cagccgcagc 340561 cgacgtccaa cagtgtcatg cccggctgca atccgagttt gcccagcgcg agatcgatct 340621 tggcgatctg cgcctcttgc agcgtcatgt cgtcgcgctc gaagtaggcg cagctgtagg 340681 tctgagtggg atcgaggaac agccggaaga agtcgtcgga caggtcgtag tgcgcctgca 340741 cgttggcgaa gtgcggcttc agctcgtcgg gcattgggat agcgtatcgt cgtcgcggtg 340801 agcgtcgtat tcgccgacgt cgacaccggc atcgacgacg cgctggccgt gatctatctg 340861 ctggccagtc ccgacgccga tctggtcggc atcgcctcga ccggcggaaa catcgcggta 340921 ggtcaagtgt gcgcgaacaa cctgagcttg ctcgaattgt gcggtgccgc agacatcccc 340981 gtgtccaaag gcgccgatga gccgctcggc ggccggtggc ccgatcaccc aaagtttcac 341041 ggccccaagg ggataggcta tgccgagctg ccggccagca atcgccggct caccgattat 341101 gacgccacga cggcctggat cgcggcggcg cactcccacg ccggcgacct gatcggtctg 341161 gtcaccggcc cgctgaccaa cctggcgctg gcgctgcgcg ccgaacccgc gctgccgagg 341221 ctgctgcgcc ggctggtgat catgggcggc atgttcgacg gccagccgat caccgaatgg 341281 aacatccggg tggatcccga ggcggccagc gaggtgttca ccgcgtgggc cggacaacga 341341 caactgccga tcgtgtgcgg tttggatctc acccggcggg tcgcgatgac accggacatt 341401 ctcgcccggc tggcgtccgt ctgcggctcg tctccggtga tgcgggtgat cgaggacgcg 341461 ctgcggttct acttcgagtc tcatgaggcg cgcggacatg ggtacctggc atatatgcac 341521 gacccgctgg ccgccgcggt cgcaatggac ccggaactcc tgacgacccg gaccgcgacg 341581 gtggatgtcg acccgacggg ggcgacggtc accgactggt ccgggaagcg aaatcccaac 341641 gcgcggatcg gcatgagcgt cgatccggcg gtgttcttcg accggttcgt cgaacggatc 341701 ggacgattcg cgcgccgaac gtgaactgac ggcgggattt tcccgaaatt ctcgccctga 341761 cgtcacgttc ggcgcaagtc attcgtagct tccctccaga taccaccgcc gctgccggta 341821 gcacagcagc aacgcggtgc cgggatcgcc gtccagcaat acctgagcgc gcgcggtgcg 341881 gccactcgcc cgatccggat cccaccaccg ctcgtcgtcc ggccacggtc cggcccacca 341941 gcgcagccga tcgtctcggc cacgaaccct cagccgcgcc gggtccgcgg agaacatccc 342001 ccggctggtc acccgtatcg ggtttccttg ggcgtcaagc aagtccaccg gatcgtcgaa 342061 cagcaccgcc ggcgacgggt cgggcaacct gccgggccac ggctgaccgg ggtcggcctg 342121 cggcaccggc tcaggggcta ctaggcccag cacggtcaac gtgatgcgtt cggccgggcc 342181 gtgtccgccg gatagcaccg gcacccgcac ggcctccgga ccgagcaagc cctgcacccg 342241 caccagcgcc cgacgggccc gaagcctgtc ctgttcaccg agcccgcccc atagcggcaa 342301 ctgcaagcct tccgatgcgg acaccgtctc caccgcctgc agccgcagca gagtcaccgc 342361 cgcggtgggc cggtcacgag cattccggtt gttcaaccac ccgtccagtt gccagcgcac 342421 ccggtcggcg gtggcgtcct cggtcagcgg ctcggcgcac cgccacaccc ggctgcgctc 342481 ttcgccgttg gcggtgacgg catgaatggc cagccgggtg cagcccactc cggcggccat 342541 cagcgcccga tgcagctcgg cggccagcga gcgcccggcg aacgccgcgg cgtcgacccg 342601 gtcgatcggc ggatcgcatg ccagctcggc ggccagatcc ggcggcggct cccgcccgca 342661 gggcgcccgt tccggttcgc cgcgggcgaa ccggtgcgcg gccaccgcgt cggcaccgaa 342721 cctggacgcc acgtcggtac gagacagcgc ggcgaactgt ccgatggtgc gaatccccat 342781 cctccacaac agatccgtca ggtcgtcccg gcccggcccg gacaggctcg gctcggtggc 342841 aagttggcgg atcgacagca gcgacagaaa ccgcgcatcg cctcccggct ccacgatgcg 342901 gccagcacgc gcggcgaaaa ccgcggtaga caaccggtcg gcgattccga cctgacactc 342961 cgcgccggcc gcggccaccg cgtcgatcag ccgctcggcc gccatctgct cggacccgaa 343021 aaaacgggcc ggcccgcgca ccggcaacac caggagcccg ggccgcagca gctcggcgcg 343081 gggcaccaga tcgtctaccg ccgcgatcac cccttcgaag agccgggcgt cgcggtcggc 343141 gtcggcagtc gctataaaca gttgcggaca ccgcgccgcc gcctcccgac gccgcaaccc 343201 tcggcgcacc ccggccgccc gcgcggtcgc cgagcaggcg atcacccggt ttgccaacgt 343261 gaccgcgacc ggggccgtcg cggataggcc cgcggccgcg gccgccgcga ccgcgggcca 343321 gtccatacac cagatcgcca gcacgcgagc ggaggccatc accgtccacg cccgttgatc 343381 tgcagccgca ccccactgat ccgccccaac cccggggtgg gcacgcccct gagggccggg 343441 gtgatctcat agccgcagac ccgggccgca agccgcgtcg acacgccttg ccagtcgccg 343501 tcggtgacca gcagggtgca gcctttttga cgggcacggg ccaccactgc ccgcgcccgc 343561 gcccgcgtca cccggcgccc tcccagaccg agcaccacca gatccatgcc gtcgatcagc 343621 acagcggcca cctcaaccgg atcggtcccg ggatctggta tcaccgcgag ccggctcaga 343681 tccgccccca tctccaccgc ggccagcaac ccgatatccg gctggccaac gatggccgcg 343741 tttcccccgg ccgccgtcac cgatgccacc atgctcagca gcagtgaccg cgcacccgac 343801 agcactccca ccgtccccgg gggcaacgac accggtcccg ccggcaccag gtcgcccgaa 343861 cggctgggcc ccccggacac cttctcggac agcaaagcca tctgccgtcg tagtgattcg 343921 agctgctcag caccattttc aaggcgttgg tcggaggcga aggccgcagt catgaccagc 343981 ctcctgttcg aaaatatgtt cgaagtcagt aaacacccgt ccttggagtc cgtcaaggtc 344041 atgagaggct gccttgtgca atcgcgtaaa accacctcgg tactggcggc tgccctgctg 344101 ttttgcggcc tgttaggccc agggacggcc ccaccggcca ccggtggcgg gcctgcctgc 344161 cggccggcag agctcttcgc caccgacaac accaccgatg ggttcgagct accggccgtt 344221 gcgactatcg cactaaccgg cacggtggtg accggatcga ccctggtcga cggcgtgttc 344281 tggtcgaatg agcgccagca gatcggctac gagcgctccc gtgaatttca tctgtgcgtt 344341 gtcgacgcgc ccacattgca caacgccgcc gaggcactgc accgccagtt caaccaagaa 344401 gcggtgctga ccttcgacta cttgccgcag aatgcacccg aggcggacgc gatcctcatc 344461 accgtgcccg acatcggcat cgcccgcttc cgcgatgcct tcgcatctga tttggctgca 344521 caccaccgat tacggggcgg atctgtcacc acagccgacc acaccttaat cctggtcgcc 344581 ggcaacggcg atctcgatgt cgcccgccga ctcgtcgagg aggccggcgg ggactggaac 344641 gcaaccacca ttgcccatgg caggcgtgaa ttcgtgaact agctgatcaa gggcgctccg 344701 ctggccaccc gagccgggtt ggtcacatta gttagtcaca gcaatctctg ggccggcggg 344761 cacaacgcgt attcatcccg acagatacca atgtgtcgcc tgtgacaaaa gccgggcctg 344821 gctaatgctg gccgccgcta ctcccactcg atggtggcgg gcggcttgct ggtgatgtcc 344881 agcaccacgc ggttgacctc ggcgacctcg ttggtgatcc gggtcgagat gcgctcgagc 344941 acctcgtagg gcacccgggt ccagtcggcg gtcatcgcgt cttcactcga caccggacgc 345001 agcacaatcg ggtggccata ggtgcgaccg tcaccctgca cacccaccga gcggacatcg 345061 gccaacagca ccaccggaca ctgccagatc tggttgtcca ggcccgccgc ggtcagctcc 345121 tcacgcacga tcgaatcggc gtgccgcagc gtatccaacc gcttggcggt gacctccccg 345181 acgatccgaa tacccaaccc cggtcccgga aacggctggc gcgccacgat ctcctccggc 345241 agacccaact cccgcccgac cgcgcgcacc tcgtctttga acagcagccg cagcggctca 345301 acgagggtga acttcaggtc gtcgggcagg ccgccgacat tgtggtggct cttgatgttc 345361 gcggtgccgc tgcccccgcc ggactccacc acatccggat acagcgtgcc ctgcaccagg 345421 aactcagcag tcttaccgtc cagcacatcc cgcaccgcgc cctcgaacgc gcggatgaac 345481 tgacggccga tgatcttgcg tttgccctcg ggggcgctca cgcccgacag cgcctcgagg 345541 aaggtctcgg ccgcgtcgac ggtgaccagg ttggcgccgg tggcggccac gaaatcgcgt 345601 tgcacctgcg cccgctcacc ggcgcgcaac agcccgtggt cgacgaagac acaggtcaac 345661 cggtcgccga tggcccgctg caccagggcc gcggccaccg cggaatccac gccgccggat 345721 agcccgcaga tggcgtggcc gtcgccgatc tgggtgcgca cctgctcgat cagcgcgttg 345781 gcgatgttgg cgggcgtcca ctgggcgccg agcccggcga agtcgtgcaa aaaccggctg 345841 agcacctgtt gcccgtgtgg ggtgtgcatc acctccgggt gatactgcac cccggccagg 345901 cgccggtcga aggcctcgaa ggcggccacc ggggcaccgg cgctgctagc caccacgtcg 345961 aatccgtccg gcgcggccgt gaccgcgtca ccgtgactca tccataccgg ctgaacctcg 346021 ggaagatccg aatgcagttt gccaccaagg actttcagtt cagtccgacc gtattcgcga 346081 gtgccggtgt gggcgacgat ccccccgagc gcctgcgcca tggcctgaaa cccgtagcag 346141 atgccaagaa ccggtacacc gaggtccagt agcgccggat cgagtttcgg agcgccgtcg 346201 gcgtagacac tggccggtcc accggaaagc acgagcgcca ccggctgacg ggccctgatc 346261 tcctcgatcg aggcggtgtg cggaatcacc tcggagaaaa cccgtgcttc tcgaacccga 346321 cgggcaatca actgggcata ttgggcaccg aagtcgacca ccaacaccgg tcgagccggt 346381 gtctcaggca cgtcgatgtc agcaggctgc accacggcca gtcagtctag tggctggggt 346441 gactcccgag gtcggccggt agcggtccat gggccggtcc gcaggttacc gaagaggcca 346501 gtgctgccgc cgccacttgg gccttcttca gtcccgacag agagattcgc cgatcgtaga 346561 cgaccgccgg cgatgctctg atcaaggcga gctgacggcg gtagatgcca gacatggccg 346621 cacagcaggc agcgctgcgg cggtcgaggt gtggaatcag ccgcagtccc agcgaatacc 346681 agtctgcggc gcggtcggca ctgaaccgca gcagtgccgc gagccgtccg tcggggtcat 346741 cgagtgcccc ggtgtcgtcc aggcggaggc gtacgcctaa tcggtccagc tcgtcgcgcg 346801 gcaggtagat ccgtccattc aaaaagtcct ctcgaacgtc gcgcagaata ttggtttgct 346861 gcagagcgat tcccaactgc tcggcgtatc gcgacgtcgc cgtgctgacg ggtccaaaga 346921 tggaaagaca aagctttccg atcgtgccgg ccccccggcg gcagtagacg atcagctcgt 346981 cgaaatcgcg gcaaccagtc cagtcgattt ccatacgggc gccgtcaatc aactctgcga 347041 acatcgcgat cggcaccgga aaccggcgag ccgcgtcagc cagcgcaacc agcaccggat 347101 cggatgaatc atcaatatta tcaagtgatt tcctgatggc atcgagctcg gtgatcttgg 347161 tctcgggggc cagctcgccg tcggcgacgt cgtcgatccg gcggccgagc gcatagaccg 347221 cagatagtgc cgctcgcttt tcgcgcggca agagtcggat gccgtagtag aagtttctgg 347281 cggccgtgcg cgtgatcgac tcggtgattc gatacgcctg ttcgatctcg gtcatgccgt 347341 cctccaacta cggtgttggt cagtcacgcc tgacgatcga cgatgtagtg agccaaatcc 347401 tgaagctcag cggccgggcg atcgggaatg ccgatgcgcg ccaccatgtc gatgccttgc 347461 gttacgtgtc ggcgggcctc cgcgcttgcc cacctgcgcc ccccaccgca ctcgatcagt 347521 tctgcgaccg ctgcgagctc atcatcggac gctgtctggc tgcccgtctc gtccaccagc 347581 cacgctgcga ggcggcggcc ggccgaaccg ccgtgcgcca cggtccaggt aacgggcaga 347641 gttttcttgc gggagcgaag gtccgagtac accggcttgc cggtgatctc aggacggccc 347701 caaatgccga gcaggtcgtc gaccaattgg aaggcaagtc caatgtgacg accgtaggca 347761 accaacgctt ctcgcaccga acgcggtgcg ccagcgagta acgcgccgac ctcggcgctg 347821 gctgccatca gtgctgcggt cttgccttca gccatcttga gacactcatc gagtgcgacg 347881 tcggttcggc tttcgaacgc ggtgtcggcg gcctgcccac ggatcaactc acgggtggct 347941 tccgaaatcg cgcgcagcgc cgcaccgacg tgtggtgaat cgcaatccag caggacctcg 348001 tgcgccagcg acagcatcgc atcaccggcc aatagcgcca tcgcatcgcc ccacagtgcc 348061 cacaccgtcg gccggtgccg acggtgctcg tcgcggtcca tgaggtcgtc atggacgagc 348121 gagaagttgt gcaccagttc aaccgagacg gctccgggaa tcgccgagtg ggggtcggcg 348181 ccggcggctt cggcggcgac aaacaccaaa gcaggacgga ttgccttgcc gcagttgttg 348241 ttcactggac ggccgcgttc atcagaccag ccgaggtggt aggacacgac gggccgcatg 348301 tggggatcga ggcggtcagc catctggcgc agcgtcggtg tgatgagttc gtgtgcgagt 348361 cccaaaacgg gaagcgtgcg acgggtcata cggtcgctgt cgggttgcgg tggcagtccg 348421 tacttttcgt cggtaccgcg cattgcgtga atctagcatt cgctcatggc acggcccatg 348481 ggcaagttgc ccagcaatac gcgaaaatgt gcacaatgtg caatggcgga ggcactattg 348541 gagatcgctg gtcagactat taatcaaaag gaccttggca ggagcggacg gatgacgcgt 348601 accgacaatg acacttggga tctggcctcc agcgtggggg cgaccgccac aatgatcgcc 348661 accgcccggg cgttggctag cagggccgaa aaccctttga tcaatgatcc attcgccgag 348721 ccgctggtgc gcgccgtcgg catcgacctg tttacccggc tggccagcgg cgagttgagg 348781 cttgaggaca tcggcgacca cgccaccggg ggtcggtgga tgatcgacaa catcgcgatt 348841 cggaccaagt tctacgatga ctttttcggt gacgcaacca cggcgggtat tcggcaggta 348901 gtgattctgg cggctgggct cgacacccgc gcgtaccgac tgccctggcc cccgggcacg 348961 gtggtctacg agatcgacca gcccgcagtc atcaagttca agacacgggc cctcgccaat 349021 ctgaacgccg aacccaacgc agaacggcac gccgtggccg tcgatctgcg aaacgattgg 349081 ccgacggcgc tgaagaacgc cggcttcgac ccggccagac cgacagcctt cagcgccgag 349141 gggttgctga gctacctgcc cccacagggg caggaccgcc tgctcgatgc gattaccgcg 349201 ctcagcgccc ctgacagccg gttggccacc cagagcccac tggtgctcga cctggccgag 349261 gaagatgaga agaagatgcg catgaaatcc gcggccgagg catggcggga acgcggcttt 349321 gatctggact tgaccgagct gatctacttc gatcaacgca acgacgtggc cgactacctc 349381 gccggctccg gctggcaggt caccaccagc accggcaagg aactctttgc ggcccaaggg 349441 ctgccgccct tcgcggacga ccacataact cggttcgccg accgccgcta catcagcgcg 349501 gtgctgaagt aggtggcccc ggcactatag ccgggcctaa ctcgtaggct tggtacgcgg 349561 gca //