ID   LRP_ECOL6      STANDARD;      PRT;   163 AA.
AC   P0ACJ1; P19494;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   02-MAY-2006, entry version 9.
DE   Leucine-responsive regulatory protein.
GN   Name=lrp; OrderedLocusNames=c_1026;
OS   Escherichia coli O6.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=217992;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O6:H1 / CFT073 / ATCC 700928 / UPEC;
RX   MEDLINE=22388234; PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P.,
RA   Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D.,
RA   Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T.,
RA   Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence
RT   of uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp
CC       mediates this effect for at least some of these operons. For
CC       example it is regulator of the branched-chain amino acid transport
CC       genes (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Contains 1 HTH asnC-type DNA-binding domain.
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DR   EMBL; AE014075; AAN79498.1; ALT_INIT; Genomic_DNA.
DR   GenomeReviews; AE014075_GR; c_1026.
DR   InterPro; IPR011008; Dimer_A_B_barrel.
DR   InterPro; IPR000485; HTH_AsnC_lrp.
DR   InterPro; IPR011991; Wing_hlx_DNA_bd.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
KW   Activator; Complete proteome; DNA-binding; Transcription;
KW   Transcription regulation.
FT   INIT_MET      0      0       By similarity.
FT   CHAIN         1    163       Leucine-responsive regulatory protein.
FT                                /FTId=PRO_0000111730.
FT   DOMAIN       11     72       HTH asnC-type.
FT   DNA_BIND     30     49       H-T-H motif (Potential).
SQ   SEQUENCE   163 AA;  18756 MW;  B0083495B8F7B255 CRC64;
     VDSKKRPGKD LDRIDRNILN ELQKDGRISN VELSKRVGLS PTPCLERVRR LERQGFIQGY
     TALLNPHYLD ASLLVFVEIT LNRGAPDVFE QFNTAVQKLE EIQECHLVSG DFDYLLKTRV
     PDMSAYRKLL GETLLRLPGV NDTRTYVVME EVKQSNRLVI KTR
//