ID   LRP_SHIFL      STANDARD;      PRT;   163 AA.
AC   P0ACJ3; P19494;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   04-APR-2006, entry version 7.
DE   Leucine-responsive regulatory protein.
GN   Name=lrp; OrderedLocusNames=SF0848, S0889;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   MEDLINE=22272406; PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H.,
RA   Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J.,
RA   Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S.,
RA   Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y.,
RA   Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2457T / ATCC 700930 / Serotype 2a;
RX   MEDLINE=22590274; PubMed=12704152;
RX   DOI=10.1128/IAI.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W.,
RA   Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A.,
RA   Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S.,
RA   Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella
RT   flexneri serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp
CC       mediates this effect for at least some of these operons. For
CC       example it is regulator of the branched-chain amino acid transport
CC       genes (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Contains 1 HTH asnC-type DNA-binding domain.
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DR   EMBL; AE005674; AAN42481.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP16353.1; -; Genomic_DNA.
DR   GenomeReviews; AE014073_GR; S0889.
DR   GenomeReviews; AE005674_GR; SF0848.
DR   InterPro; IPR011008; Dimer_A_B_barrel.
DR   InterPro; IPR000485; HTH_AsnC_lrp.
DR   InterPro; IPR011991; Wing_hlx_DNA_bd.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
KW   Activator; Complete proteome; DNA-binding; Transcription;
KW   Transcription regulation.
FT   INIT_MET      0      0       By similarity.
FT   CHAIN         1    163       Leucine-responsive regulatory protein.
FT                                /FTId=PRO_0000111737.
FT   DOMAIN       11     72       HTH asnC-type.
FT   DNA_BIND     30     49       H-T-H motif (Potential).
SQ   SEQUENCE   163 AA;  18756 MW;  B0083495B8F7B255 CRC64;
     VDSKKRPGKD LDRIDRNILN ELQKDGRISN VELSKRVGLS PTPCLERVRR LERQGFIQGY
     TALLNPHYLD ASLLVFVEIT LNRGAPDVFE QFNTAVQKLE EIQECHLVSG DFDYLLKTRV
     PDMSAYRKLL GETLLRLPGV NDTRTYVVME EVKQSNRLVI KTR
//