ID   LRP_ENTAE      STANDARD;      PRT;   163 AA.
AC   P0ACJ4; P19494;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   21-MAR-2006, entry version 6.
DE   Leucine-responsive regulatory protein.
GN   Name=lrp;
OS   Enterobacter aerogenes (Aerobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95189743; PubMed=7883720;
RA   Friedberg D., Platko J.V., Tyler B., Calvo J.M.;
RT   "The amino acid sequence of Lrp is highly conserved in four enteric
RT   microorganisms.";
RL   J. Bacteriol. 177:1624-1626(1995).
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp
CC       mediates this effect for at least some of these operons. For
CC       example it is regulator of the branched-chain amino acid transport
CC       genes (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Contains 1 HTH asnC-type DNA-binding domain.
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DR   EMBL; U02272; AAA75439.1; -; Genomic_DNA.
DR   InterPro; IPR011008; Dimer_A_B_barrel.
DR   InterPro; IPR000485; HTH_AsnC_lrp.
DR   InterPro; IPR011991; Wing_hlx_DNA_bd.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   INIT_MET      0      0       By similarity.
FT   CHAIN         1    163       Leucine-responsive regulatory protein.
FT                                /FTId=PRO_0000111727.
FT   DOMAIN       11     72       HTH asnC-type.
FT   DNA_BIND     30     49       H-T-H motif (Potential).
SQ   SEQUENCE   163 AA;  18756 MW;  B0083495B8F7B255 CRC64;
     VDSKKRPGKD LDRIDRNILN ELQKDGRISN VELSKRVGLS PTPCLERVRR LERQGFIQGY
     TALLNPHYLD ASLLVFVEIT LNRGAPDVFE QFNTAVQKLE EIQECHLVSG DFDYLLKTRV
     PDMSAYRKLL GETLLRLPGV NDTRTYVVME EVKQSNRLVI KTR
//