ID   LRP_ECO57      STANDARD;      PRT;   163 AA.
AC   P0ACJ2; P19494;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   02-MAY-2006, entry version 8.
DE   Leucine-responsive regulatory protein.
GN   Name=lrp; OrderedLocusNames=Z1234, ECs0974;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   MEDLINE=21074935; PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   MEDLINE=21156231; PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp
CC       mediates this effect for at least some of these operons. For
CC       example it is regulator of the branched-chain amino acid transport
CC       genes (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Contains 1 HTH asnC-type DNA-binding domain.
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DR   EMBL; AE005174; AAG55376.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34397.1; -; Genomic_DNA.
DR   PIR; D85614; D85614.
DR   PIR; F90750; F90750.
DR   GenomeReviews; BA000007_GR; ECs0974.
DR   GenomeReviews; AE005174_GR; Z1234.
DR   InterPro; IPR011008; Dimer_A_B_barrel.
DR   InterPro; IPR000485; HTH_AsnC_lrp.
DR   InterPro; IPR011991; Wing_hlx_DNA_bd.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
KW   Activator; Complete proteome; DNA-binding; Transcription;
KW   Transcription regulation.
FT   INIT_MET      0      0       By similarity.
FT   CHAIN         1    163       Leucine-responsive regulatory protein.
FT                                /FTId=PRO_0000111729.
FT   DOMAIN       11     72       HTH asnC-type.
FT   DNA_BIND     30     49       H-T-H motif (Potential).
SQ   SEQUENCE   163 AA;  18756 MW;  B0083495B8F7B255 CRC64;
     VDSKKRPGKD LDRIDRNILN ELQKDGRISN VELSKRVGLS PTPCLERVRR LERQGFIQGY
     TALLNPHYLD ASLLVFVEIT LNRGAPDVFE QFNTAVQKLE EIQECHLVSG DFDYLLKTRV
     PDMSAYRKLL GETLLRLPGV NDTRTYVVME EVKQSNRLVI KTR
//