ID DCHS_ENTAE STANDARD; PRT; 377 AA. AC P28577; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Histidine decarboxylase (EC 4.1.1.22) (HDC). GN Name=hdc; OS Enterobacter aerogenes (Aerobacter aerogenes). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Enterobacter. OX NCBI_TaxID=548; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=91236707; PubMed=2033044; RA Kamath A.V., Vaaler G.L., Snell E.E.; RT "Pyridoxal phosphate-dependent histidine decarboxylases. Cloning, RT sequencing, and expression of genes from Klebsiella planticola and RT Enterobacter aerogenes and properties of the overexpressed enzymes."; RL J. Biol. Chem. 266:9432-9437(1991). CC -!- CATALYTIC ACTIVITY: L-histidine = histamine + CO(2). CC -!- COFACTOR: Pyridoxal phosphate. CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SIMILARITY: Belongs to the group II decarboxylase family. CC -------------------------------------------------------------------------- CC This Swiss-Prot entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use as long as its content is in no way modified and this statement is not CC removed. CC -------------------------------------------------------------------------- DR EMBL; M62745; AAA24802.1; -. DR PIR; A40004; A40004. DR HAMAP; MF_00609; -; 1. DR InterPro; IPR002129; Pyridoxal_deC. DR Pfam; PF00282; Pyridoxal_deC; 1. DR PROSITE; PS00392; DDC_GAD_HDC_YDC; 1. KW Decarboxylase; Lyase; Pyridoxal phosphate. FT INIT_MET 0 0 By similarity. FT BINDING 232 232 Pyridoxal phosphate (covalent) FT (Potential). SQ SEQUENCE 377 AA; 42303 MW; 4C7A3334ACA7D6AE CRC64; SLSIADQNKL DAFWSYCVKN RYFNIGYPES ADFDYTMLER FLRFSINNCG DWGEYCNYLL NSFDFEKEVM EYFSGIFKIP FAESWGYVTN GGTESNMFGC YLGRELFPEG TLYYSKDTHY SVAKIVKLLR IKSQLVESQP DGEMDYDDLI NKIRTSGERH PIIFANIGTT VRGAVDNIAE IQKRIAALGI PREDYYLHAD AALSGMILPF VEDPQPFTFA DGIDSIGVSG HKMIGSPIPC GIVVAKKANV DRISVEIDYI SAHDKTISGS RNGHTPLMMW AAVRSHTDAE WHRRIGHSLN MAKYAVDRFK AAGIDALCHK NSITVVFPKP SEWVWKKHCL ATSGNVAHLI TTAHHLDSSR IDALIDDVIA DLAQRAA //