ID   DCHS_ENTAE     STANDARD;      PRT;   377 AA.
AC   P28577;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   07-FEB-2006, entry version 34.
DE   Histidine decarboxylase (EC 4.1.1.22) (HDC).
GN   Name=hdc;
OS   Enterobacter aerogenes (Aerobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91236707; PubMed=2033044;
RA   Kamath A.V., Vaaler G.L., Snell E.E.;
RT   "Pyridoxal phosphate-dependent histidine decarboxylases. Cloning,
RT   sequencing, and expression of genes from Klebsiella planticola and
RT   Enterobacter aerogenes and properties of the overexpressed enzymes.";
RL   J. Biol. Chem. 266:9432-9437(1991).
CC   -!- CATALYTIC ACTIVITY: L-histidine = histamine + CO(2).
CC   -!- COFACTOR: Pyridoxal phosphate.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
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DR   EMBL; M62745; AAA24802.1; -; Genomic_DNA.
DR   PIR; A40004; A40004.
DR   HAMAP; MF_00609; -; 1.
DR   InterPro; IPR002129; Pyridoxal_deC.
DR   PANTHER; PTHR11999; Pyridoxal_deC; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
KW   Decarboxylase; Lyase; Pyridoxal phosphate.
FT   INIT_MET      0      0       By similarity.
FT   CHAIN         1    377       Histidine decarboxylase.
FT                                /FTId=PRO_0000146955.
FT   BINDING     232    232       Pyridoxal phosphate (covalent)
FT                                (Potential).
SQ   SEQUENCE   377 AA;  42303 MW;  4C7A3334ACA7D6AE CRC64;
     SLSIADQNKL DAFWSYCVKN RYFNIGYPES ADFDYTMLER FLRFSINNCG DWGEYCNYLL
     NSFDFEKEVM EYFSGIFKIP FAESWGYVTN GGTESNMFGC YLGRELFPEG TLYYSKDTHY
     SVAKIVKLLR IKSQLVESQP DGEMDYDDLI NKIRTSGERH PIIFANIGTT VRGAVDNIAE
     IQKRIAALGI PREDYYLHAD AALSGMILPF VEDPQPFTFA DGIDSIGVSG HKMIGSPIPC
     GIVVAKKANV DRISVEIDYI SAHDKTISGS RNGHTPLMMW AAVRSHTDAE WHRRIGHSLN
     MAKYAVDRFK AAGIDALCHK NSITVVFPKP SEWVWKKHCL ATSGNVAHLI TTAHHLDSSR
     IDALIDDVIA DLAQRAA
//