ID   DYR_ENTAE      STANDARD;      PRT;   159 AA.
AC   P31074;
DT   01-JUL-1993 (Rel. 26, Created)
DT   01-JUL-1993 (Rel. 26, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   Dihydrofolate reductase (EC 1.5.1.3).
GN   Name=folA;
OS   Enterobacter aerogenes (Aerobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=92114753; PubMed=1766362;
RA   Garvin L.D., Hardies S.C.;
RT   "Temporal and topological clustering of diverged residues among
RT   enterobacterial dihydrofolate reductases.";
RL   Mol. Biol. Evol. 8:654-668(1991).
CC   -!- CATALYTIC ACTIVITY: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-
CC       dihydrofolate + NADPH.
CC   -!- PATHWAY: Essential step for de novo glycine and purine synthesis,
CC       DNA precursor synthesis, and for the conversion of dUMP to dTMP.
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; M26022; AAA24800.1; -.
DR   PIR; A39799; A39799.
DR   HSSP; P00379; 5DFR.
DR   InterPro; IPR001796; DHFR.
DR   Pfam; PF00186; DiHfolate_red; 1.
DR   PRINTS; PR00070; DHFR.
DR   PROSITE; PS00075; DHFR; 1.
KW   NADP; One-carbon metabolism; Oxidoreductase.
SQ   SEQUENCE   159 AA;  17974 MW;  73C9B8D31D0C1C07 CRC64;
     MISLIAALAV DRVIGMENAM PWDLPADLAW FKRNTLNKPV VMGRLTWESI GRPLPGRKNI
     VISSKPGSDD RVQWVKSVDE AIAACGDAEE IMVIGGGRVY EQFLPKAHKL YLTHIDAEVE
     GDTHFPDYDP DEWESVFSEF HDADAQNSHS YCFEILERR
//