ID   ALR2_KLEAE     STANDARD;      PRT;   356 AA.
AC   O30746;
DT   15-DEC-1998 (Rel. 37, Created)
DT   15-DEC-1998 (Rel. 37, Last sequence update)
DT   01-FEB-2005 (Rel. 46, Last annotation update)
DE   Alanine racemase, catabolic (EC 5.1.1.1).
GN   Name=dadB;
OS   Klebsiella aerogenes.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=28451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=W70;
RX   MEDLINE=98117036; PubMed=9457858;
RA   Janes B.K., Bender R.A.;
RT   "Alanine catabolism in Klebsiella aerogenes: molecular
RT   characterization of the dadAB operon and its regulation by the
RT   nitrogen assimilation control protein.";
RL   J. Bacteriol. 180:563-570(1998).
CC   -!- FUNCTION: Isomerizes L-alanine to D-alanine which is then oxidized
CC       to pyruvate by dadA.
CC   -!- CATALYTIC ACTIVITY: L-alanine = D-alanine.
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- PATHWAY: Alanine catabolism; first step.
CC   -!- INDUCTION: By alanine.
CC   -!- SIMILARITY: Belongs to the alanine racemase family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AF016253; AAC38140.1; -.
DR   HSSP; P10724; 1BD0.
DR   HAMAP; MF_01201; -; 1.
DR   InterPro; IPR000821; Ala_racemase.
DR   InterPro; IPR011079; Ala_racemase_C.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR009006; Racem_decarbox_C.
DR   Pfam; PF00842; Ala_racemase_C; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PRINTS; PR00992; ALARACEMASE.
DR   TIGRFAMs; TIGR00492; alr; 1.
DR   PROSITE; PS00395; ALANINE_RACEMASE; 1.
KW   Isomerase; Pyridoxal phosphate.
FT   ACT_SITE     35     35       Proton acceptor; specific for D-alanine
FT                                (By similarity).
FT   ACT_SITE    253    253       Proton acceptor; specific for L-alanine
FT                                (By similarity).
FT   BINDING      35     35       Pyridoxal phosphate (covalent) (By
FT                                similarity).
SQ   SEQUENCE   356 AA;  38788 MW;  45A7CD7E56855856 CRC64;
     MTRPVVASID LLALRQNLQI VRRAAPGSRL WAVDKDNAYG HGVARVWSAL SAADGFALLN
     LEEAILLREQ GWKGPILLLE GFFHADELAV LDQYRLPTSV HSNWQIKALQ QAKLRAPLDI
     YLKVNSGMNR LGFMPERVHT VWQQLRAISN VGEMTLMSHF AEAENPQGIV EPMRRIEQAA
     EGLDCPRSLA NSAATLWHPE AHFDWVRPGI VLYGASPSGQ WQDIANTGLK PVMTLRSEII
     GVQNLRPGEA IGYGGLYRTT QEQRIGIVAC GYADGYPRVA PSGTPVLVDG VRTTTVGRVS
     MDMLAVDLTP CPQAGIGAPV ELWGKEIKID DVAASSGTVG YELMCALAPR VPVVTL
//