ID   AAC6_KLEPN     STANDARD;      PRT;   201 AA.
AC   P19650;
DT   01-FEB-1991 (Rel. 17, Created)
DT   01-FEB-1991 (Rel. 17, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   Aminoglycoside N(6')-acetyltransferase (EC 2.3.1.82) (Amikacin
DE   resistance protein) (AAC(6')).
GN   Name=aacA4;
OS   Klebsiella pneumoniae.
OG   Plasmid pJHC-MW1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TRANSPOSON=Tn1331;
RX   MEDLINE=88298697; PubMed=2841303;
RA   Nobuta K., Tolmasky M.E., Crosa L.M., Crosa J.H.;
RT   "Sequencing and expression of the 6'-N-acetyltransferase gene of
RT   transposon Tn1331 from Klebsiella pneumoniae.";
RL   J. Bacteriol. 170:3769-3773(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TRANSPOSON=Tn1331;
RX   MEDLINE=91172904; PubMed=1963948;
RA   Tolmasky M.E.;
RT   "Sequencing and expression of aadA, bla, and tnpR from the
RT   multiresistance transposon Tn1331.";
RL   Plasmid 24:218-226(1990).
CC   -!- FUNCTION: Resistance to antibiotics containing the purpurosamine
CC       ring including gentamicin, kanamycin, tobramycin, and neomycin.
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + kanamycin-B = CoA + N(6')-
CC       acetylkanamycin-B.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; M21682; AAA69747.1; -.
DR   EMBL; M21682; AAA69748.1; ALT_INIT.
DR   EMBL; M55547; AAA98404.1; -.
DR   PIR; B31104; B31104.
DR   InterPro; IPR000182; GCN5acetyl_trans.
DR   Pfam; PF00583; Acetyltransf_1; 1.
KW   Acyltransferase; Antibiotic resistance; Plasmid; Transferase;
KW   Transposable element.
SQ   SEQUENCE   201 AA;  22407 MW;  ED0314DCDF05BEDC CRC64;
     MSIQHFQTKL GITKYSIVTN SNDSVTLRLM TEHDLAMLYE WLNRSHIVEW WGGEEARPTL
     ADVQEQYLPS VLAQESVTPY IAMLNGEPIG YAQSYVALGS GDGWWEEETD PGVRGIDQLL
     ANASQLGKGL GTKLVRALVE LLFNDPEVTK IQTDPSPSNL RAIRCYEKAG FERQGTVTTP
     DGPAVYMVQT RQAFERTRSV A
//