ID   AAD2_KLEPN     STANDARD;      PRT;   177 AA.
AC   P29806;
DT   01-APR-1993 (Rel. 25, Created)
DT   01-APR-1993 (Rel. 25, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   2''-aminoglycoside nucleotidyltransferase (EC 2.7.7.46) (AAD(2''))
DE   (Gentamicin 2''-nucleotidyltransferase) (Gentamicin resistance
DE   protein).
GN   Name=aadB;
OS   Klebsiella pneumoniae.
OG   Plasmid pLST1000.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Zieg J., Jiang H., McCabe F., O'Brien T.;
RL   Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This enzyme confers resistance to kanamycin, gentamicin,
CC       dibekacin, sisomicin, neomycin and tobramycin by adenylating the
CC       2''-hydroxyl group of these antibiotics.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + gentamicin =
CC       diphosphate + 2''-nucleotidylgentamicin.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; X64369; CAA45722.1; -.
DR   PIR; S19940; XNKBLS.
KW   Antibiotic resistance; Nucleotidyltransferase; Plasmid; Transferase.
SQ   SEQUENCE   177 AA;  19861 MW;  F941A0785D77E719 CRC64;
     MDTTQVTLIH QILAAADERN LPLWIGGGWA IDARLGRVTR KHDDIDLTFP GERRGELEAM
     VEMLGGRVTE ELDYGFLAEI GDELLDCEPA WWADEAYEIA EAPQGSCPEA AEGVIAGRPV
     RCNSWEAIIW DYFYYADEVP PVDWPTKHIE SYRLACTSLG AEKVEVLRAA FRSRYAA
//