ID   CITN_KLEPN     STANDARD;      PRT;   446 AA.
AC   P31602;
DT   01-JUL-1993 (Rel. 26, Created)
DT   01-JUL-1993 (Rel. 26, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   Citrate-sodium symport (Citrate transporter) (Citrate carrier
DE   protein).
GN   Name=citS;
OS   Klebsiella pneumoniae.
OG   Plasmid pES3.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 13882;
RX   MEDLINE=92250486; PubMed=1577734;
RA   van der Rest M.E., Siewe R.M., Abee T., Schwarz E., Oesterhelt D.,
RA   Konings W.N.;
RT   "Nucleotide sequence and functional properties of a sodium-dependent
RT   citrate transport system from Klebsiella pneumoniae.";
RL   J. Biol. Chem. 267:8971-8976(1992).
RN   [2]
RP   TOPOLOGY.
RX   MEDLINE=96411779; PubMed=8810332; DOI=10.1074/jbc.271.41.25582;
RA   van Geest M., Lolkema J.S.;
RT   "Membrane topology of the sodium ion-dependent citrate carrier of
RT   Klebsiella pneumoniae. Evidence for a new structural class of
RT   secondary transporters.";
RL   J. Biol. Chem. 271:25582-25589(1996).
CC   -!- FUNCTION: Uptake of citrate across the boundary membrane with the
CC       concomitant uptake of a sodium ion (symport system).
CC   -!- PATHWAY: Allows the utilization of citrate as a sole source of
CC       carbon and energy.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC   -!- SIMILARITY: Belongs to the sodium:citrate (SCF) symporter family.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; M83146; AAA25060.1; -.
DR   PIR; A38244; A38244.
DR   InterPro; IPR004679; Cit_carr.
DR   Pfam; PF03390; Na_citrate; 1.
DR   ProDom; PD007103; Cit_carr; 1.
DR   TIGRFAMs; TIGR00783; ccs; 1.
KW   Citrate utilization; Plasmid; Symport; Transmembrane; Transport.
FT   DOMAIN        1     22       Cytoplasmic (Probable).
FT   TRANSMEM     23     43       I (Probable).
FT   DOMAIN       44     45       Periplasmic (Probable).
FT   TRANSMEM     46     66       II (Probable).
FT   DOMAIN       67     78       Cytoplasmic (Probable).
FT   TRANSMEM     79     99       III (Probable).
FT   DOMAIN      100    109       Periplasmic (Probable).
FT   TRANSMEM    110    130       IV (Probable).
FT   DOMAIN      131    147       Cytoplasmic (Probable).
FT   TRANSMEM    148    168       V (Probable).
FT   DOMAIN      169    212       Periplasmic (Probable).
FT   TRANSMEM    213    233       VI (Probable).
FT   DOMAIN      234    266       Cytoplasmic (Probable).
FT   TRANSMEM    267    287       VII (Probable).
FT   DOMAIN      288    360       Periplasmic (Probable).
FT   TRANSMEM    361    379       VIII (Probable).
FT   DOMAIN      380    426       Cytoplasmic (Probable).
FT   TRANSMEM    427    446       IX (Probable).
SQ   SEQUENCE   446 AA;  47558 MW;  D90AB990BDDDE879 CRC64;
     MTNMSQPPAT EKKGVSDLLG FKIFGMPLPL YAFALITLLL SHFYNALPTD IVGGFAIMFI
     IGAIFGEIGK RLPIFNKYIG GAPVMIFLVA AYFVYAGIFT QKEIDAISNV MDKSNFLNLF
     IAVLITGAIL SVNRRLLLKS LLGYIPTILM GIVGASIFGI AIGLVFGIPV DRIMMLYVLP
     IMGGGNGAGA VPLSEIYHSV TGRSREEYYS TAIAILTIAN IFAIVFAAVL DIIGKKHTWL
     SGEGELVRKA SFKVEEDEKT GQITHRETAV GLVLSTTCFL LAYVVAKKIL PSIGGVAIHY
     FAWMVLIVAA LNASGLCSPE IKAGAKRLSD FFSKQLLWVL MVGVGVCYTD LQEIINAITF
     ANVVIAAIIV IGAVLGAAIG GWLMGFFPIE SAITAGLCMA NRGGSGDLEV LSACNRMNLI
     SYAQISSRLG GGIVLVIASI VFGMMI
//