ID   IL5_CAVPO      STANDARD;      PRT;   135 AA.
AC   O08987;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   21-MAR-2006, entry version 37.
DE   Interleukin-5 precursor (IL-5) (T-cell replacing factor) (TRF)
DE   (Eosinophil differentiation factor).
GN   Name=IL5;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96289181; PubMed=8764226;
RA   Mansour M., Karmilowicz M., Hawrylik S.J., Nalcerio B., Angilly J.,
RA   Conklyn M.J., Lilly C.M., Drazen J.M., Lee S.E., Auperin D.D.,
RA   de Wet J.R., Cohan V.L., Showell H.J., Danley D.E.;
RT   "Production and characterization of guinea pig IL-5 in baculovirus-
RT   infected insect cells.";
RL   Am. J. Physiol. 270:L1002-L1007(1996).
CC   -!- FUNCTION: Factor that induces terminal differentiation of late-
CC       developing B-cells to immunoglobulin secreting cells (By
CC       similarity).
CC   -!- SUBUNIT: Homodimer; disulfide-linked (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted protein.
CC   -!- SIMILARITY: Belongs to the IL-5 family.
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DR   EMBL; U34588; AAB61357.1; -; mRNA.
DR   HSSP; P05113; 1HUL.
DR   SMR; O08987; 29-131.
DR   InterPro; IPR009079; 4_helix_cytokine.
DR   InterPro; IPR012351; Cytokine_4_hlx.
DR   InterPro; IPR000186; Interleukin_5.
DR   PANTHER; PTHR10525; Interleukin_5; 1.
DR   Pfam; PF02025; IL5; 1.
DR   PRINTS; PR00432; INTERLEUKIN5.
DR   ProDom; PD006721; Interleukin_5; 1.
KW   Cytokine; Glycoprotein; Growth factor; Signal.
FT   SIGNAL        1     19       By similarity.
FT   CHAIN        20    135       Interleukin-5.
FT                                /FTId=PRO_0000015556.
FT   CARBOHYD     48     48       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     77     77       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     91     91       N-linked (GlcNAc...) (Potential).
FT   DISULFID     64     64       Interchain (with C-106) (By similarity).
FT   DISULFID    106    106       Interchain (with C-64) (By similarity).
SQ   SEQUENCE   135 AA;  15291 MW;  EB85252132F52731 CRC64;
     MRVLLQLGLL ALGAVCVCAI PKQSATLRAL VRETLTLLST HRTLLKGNET LRISVPAHKN
     HQLCIEEIFQ GIDTLKNQTT QGEALATLFQ NLSLIKKHID LQKQKCGEER RRVKQFLDYL
     QEFLAVINTE WTIEG
//