ID   KRUP_DROME     STANDARD;      PRT;   502 AA.
AC   P07247; Q8SYW3; Q9W0V9;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   16-MAY-2006, entry version 62.
DE   Protein krueppel.
GN   Name=Kr; ORFNames=CG3340;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Rosenberg U.B., Schroeder C., Preiss A., Kienlin A., Cote S.,
RA   Riede I., Jaeckle H.;
RT   "Structural homology of the product of the Drosophila Krueppel gene
RT   with Xenopus transcription factor IIIA.";
RL   Nature 319:336-339(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RX   MEDLINE=22426069; PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   MEDLINE=22426066; PubMed=12537569;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA   George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA   Rubin G.M., Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 240-314.
RX   MEDLINE=93066327; PubMed=1438276;
RA   Sommer R.J., Retzlaff M., Goerlich K., Sander K., Tautz D.;
RT   "Evolutionary conservation pattern of zinc-finger domains of
RT   Drosophila segmentation genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:10782-10786(1992).
RN   [6]
RP   SUBCELLULAR LOCATION, DNA-BINDING, AND PHOSPHORYLATION.
RX   MEDLINE=87289672; PubMed=3112773;
RA   Ollo R., Maniatis T.;
RT   "Drosophila Kruppel gene product produced in a baculovirus expression
RT   system is a nuclear phosphoprotein that binds to DNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:5700-5704(1987).
CC   -!- FUNCTION: Krueppel is a gap class segmentation protein. It is
CC       involved in the segmentation of the embryo and in the
CC       differentiation of the Malpighian tubules.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromatin associated.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
CC   -!- CAUTION: Ref.1 sequence differs from that shown due to a
CC       frameshift in position 411.
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DR   EMBL; X03414; CAA27148.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE003466; AAF47321.1; -; Genomic_DNA.
DR   EMBL; AY071280; AAL48902.1; -; mRNA.
DR   PIR; A24566; TWFF.
DR   UniGene; Dm.2786; -.
DR   HSSP; P08047; 1SP2.
DR   TRANSFAC; T00456; -.
DR   Ensembl; CG3340; Drosophila melanogaster.
DR   FlyBase; FBgn0001325; Kr.
DR   GO; GO:0003677; F:DNA binding; IDA.
DR   GO; GO:0016564; F:transcriptional repressor activity; IDA.
DR   GO; GO:0007411; P:axon guidance; IMP.
DR   GO; GO:0007456; P:eye development (sensu Endopterygota); IMP.
DR   GO; GO:0007402; P:ganglion mother cell fate determination; TAS.
DR   GO; GO:0007443; P:Malpighian tubule morphogenesis; TAS.
DR   GO; GO:0007517; P:muscle development; TAS.
DR   GO; GO:0007400; P:neuroblast fate determination; IEP.
DR   GO; GO:0040034; P:regulation of development, heterochronic; TAS.
DR   GO; GO:0007419; P:ventral cord development; NAS.
DR   InterPro; IPR007087; Znf_C2H2.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   ProDom; PD000003; Znf_C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
KW   Complete proteome; Developmental protein; DNA-binding; Gap protein;
KW   Metal-binding; Nuclear protein; Phosphorylation; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    502       Protein krueppel.
FT                                /FTId=PRO_0000046992.
FT   ZN_FING     222    244       C2H2-type 1.
FT   ZN_FING     250    272       C2H2-type 2.
FT   ZN_FING     278    300       C2H2-type 3.
FT   ZN_FING     306    328       C2H2-type 4.
FT   ZN_FING     334    354       C2H2-type 5.
FT   CONFLICT    153    154       HE -> Q (in Ref. 4).
FT   CONFLICT    181    182       HT -> LS (in Ref. 1).
FT   CONFLICT    256    256       H -> D (in Ref. 1).
FT   CONFLICT    329    329       N -> T (in Ref. 1).
FT   CONFLICT    397    397       G -> S (in Ref. 1).
FT   CONFLICT    429    429       C -> Y (in Ref. 1).
SQ   SEQUENCE   502 AA;  54715 MW;  67A94177A701D976 CRC64;
     MSISMLQDAQ TRTLAAALAG IKQEDVHLDR SMSLSPPMSA NTSATSAAAI YPAMGLQQAA
     AASAFGMLSP TQLLAANRQA AAFMAQLPMS TLANTLFPHN PAALFGAWAA QQSLPPQGTH
     LHSPPASPHS PLSTPLGSGK HPLNSPNSTP QHHEPAKKAR KLSVKKEFQT EISMSVNDMY
     HTSGGPISPP SSGSSPNSTH DGAGGNAGCV GVSKDPSRDK SFTCKICSRS FGYKHVLQNH
     ERTHTGEKPF ECPECHKRFT RDHHLKTHMR LHTGEKPYHC SHCDRQFVQV ANLRRHLRVH
     TGERPYTCEI CDGKFSDSNQ LKSHMLVHNG EKPFECERCH MKFRRRHHLM NHKCGIQSPP
     TPALSPAMSG DYPVAISAIA IEASTNRFAA MCATYGGSNE SVDMEKATPE DDGPLDLSED
     GASSVDGHCS NIARRKAQDI RRVFRLPPPQ IPHVPSDMPE QTEPEDLSMH SPRSIGSHEQ
     TDDIDLYDLD DAPASYMGHQ QH
//