ID   GRP_HUMAN      STANDARD;      PRT;   148 AA.
AC   P07492; P07491; P81553; Q14454; Q9BSY7;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   18-APR-2006, entry version 56.
DE   Gastrin-releasing peptide precursor (GRP) [Contains: Neuromedin C
DE   (GRP-10)].
GN   Name=GRP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING.
RX   MEDLINE=86094341; PubMed=3001723;
RA   Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.;
RT   "Two prohormones for gastrin-releasing peptide are encoded by two
RT   mRNAs differing by 19 nucleotides.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=89096899; PubMed=3211139;
RA   Lebacq-Verheyden A.M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K.,
RA   Lebacq J.A., Battey J.F.;
RT   "Posttranslational processing of endogenous and of baculovirus-
RT   expressed human gastrin-releasing peptide precursor.";
RL   Mol. Cell. Biol. 8:3129-3135(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE, AND ALTERNATIVE SPLICING.
RX   MEDLINE=86111953; PubMed=3003116;
RA   Sausville E.A., Lebacq-Verheyden A.M., Spindel E.R., Cuttitta F.,
RA   Gazdar A.F., Battey J.F.;
RT   "Expression of the gastrin-releasing peptide gene in human small cell
RT   lung cancer. Evidence for alternative processing resulting in three
RT   distinct mRNAs.";
RL   J. Biol. Chem. 261:2451-2457(1986).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: GRP stimulates gastrin release as well as other
CC       gastrointestinal hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P07492-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P07492-2; Sequence=VSP_000549;
CC       Name=3;
CC         IsoId=P07492-3; Sequence=VSP_000550;
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin B/ranatensin
CC       family.
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DR   EMBL; K02054; AAA52613.1; -; mRNA.
DR   EMBL; M12550; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; M12512; AAA52612.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; M12511; AAA52612.1; JOINED; Genomic_DNA.
DR   EMBL; M12512; AAA52611.1; -; Genomic_DNA.
DR   EMBL; M12511; AAA52611.1; JOINED; Genomic_DNA.
DR   EMBL; BC004488; AAH04488.1; -; mRNA.
DR   PIR; A26182; A26182.
DR   PIR; B26182; B26182.
DR   UniGene; Hs.153444; -.
DR   Ensembl; ENSG00000134443; Homo sapiens.
DR   HGNC; HGNC:4605; GRP.
DR   H-InvDB; HIX0014482; -.
DR   MIM; 137260; gene.
DR   GO; GO:0005615; C:extracellular space; IDA.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IDA.
DR   GO; GO:0005102; F:receptor binding; NAS.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA.
DR   GO; GO:0007165; P:signal transduction; NAS.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Signal.
FT   SIGNAL        1     23
FT   PEPTIDE      24     50       Gastrin-releasing peptide.
FT                                /FTId=PRO_0000003035.
FT   PEPTIDE      41     50       Neuromedin C.
FT                                /FTId=PRO_0000003036.
FT   PROPEP       54    148
FT                                /FTId=PRO_0000003037.
FT   MOD_RES      50     50       Methionine amide (G-51 provides amide
FT                                group).
FT   VARSPLIC    122    148       VGSKGKVGRLSAPGSQREGRNPQLNQQ -> LVDSLLQVLN
FT                                VKEGTPS (in isoform 2).
FT                                /FTId=VSP_000549.
FT   VARSPLIC    128    134       Missing (in isoform 3).
FT                                /FTId=VSP_000550.
FT   CONFLICT      4      4       S -> R (in Ref. 4).
SQ   SEQUENCE   148 AA;  16144 MW;  2B55B93904825466 CRC64;
     MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS
     VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK
     DVGSKGKVGR LSAPGSQREG RNPQLNQQ
//