ID   GSTA3_CHICK    STANDARD;      PRT;   228 AA.
AC   P26697;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   04-APR-2006, entry version 43.
DE   Glutathione S-transferase 3 (EC 2.5.1.18) (GST-CL3) (GST class-alpha).
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae;
OC   Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=White leghorn; TISSUE=Liver;
RX   MEDLINE=92143826; PubMed=1339283;
RA   Chang L.-H., Fan J.-Y., Liu L.-F., Tsai S.-P., Tam M.F.;
RT   "Cloning and expression of a chick liver glutathione S-transferase CL
RT   3 subunit with the use of a baculovirus expression system.";
RL   Biochem. J. 281:545-551(1992).
CC   -!- FUNCTION: Catalyzes the conjugation of GSH to a wide variety of
CC       electrophilic alkylating agents. Also involved in the metabolism
CC       of lipid hydroperoxides, prostaglandins and leukotriene A4 and in
CC       binding of non-substrate hydrophobic ligands such as bile acids, a
CC       number of drugs and thyroid hormones. This GST does not exhibit
CC       peroxidase activity.
CC   -!- CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.
CC   -!- SUBUNIT: Homodimer or heterodimer (with a subunit from group
CC       CL-4).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- MISCELLANEOUS: The variations were found from AA sequencing and
CC       imply there are multiple forms of CL-3.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Alpha family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M38219; AAA62731.1; -; mRNA.
DR   PIR; S19734; S19734.
DR   UniGene; Gga.788; -.
DR   PDB; 1VF1; X-ray; A=1-228.
DR   PDB; 1VF2; X-ray; A/B=1-228.
DR   PDB; 1VF3; X-ray; A/B=1-228.
DR   PDB; 1VF4; X-ray; A=1-228.
DR   Ensembl; ENSGALG00000016322; Gallus gallus.
DR   InterPro; IPR003080; GST_alpha.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR010987; GST_C_like.
DR   InterPro; IPR004045; GST_N.
DR   InterPro; IPR012336; Thiordxn-like_fd.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01266; GSTRNSFRASEA.
KW   3D-structure; Direct protein sequencing; Polymorphism; Transferase.
FT   INIT_MET      0      0
FT   CHAIN         1    228       Glutathione S-transferase 3.
FT                                /FTId=PRO_0000185800.
FT   MOD_RES       1      1       Blocked amino end (Ala).
FT   VARIANT      44     44       L -> V.
FT   VARIANT      46     46       S -> A.
FT   VARIANT      48     48       I -> F.
FT   VARIANT      48     48       I -> V.
FT   VARIANT      51     51       F -> R.
FT   VARIANT     128    129       TS -> AN.
FT   VARIANT     134    135       AY -> VF.
FT   VARIANT     154    154       W -> R.
FT   VARIANT     157    158       IH -> VV.
FT   VARIANT     162    162       A -> T.
FT   VARIANT     165    165       M -> A.
FT   VARIANT     167    167       E -> V.
FT   STRAND        5      8
FT   STRAND       10     11
FT   TURN         13     15
FT   HELIX        16     24
FT   TURN         25     26
FT   STRAND       30     33
FT   STRAND       36     36
FT   HELIX        37     46
FT   TURN         47     47
FT   STRAND       49     49
FT   TURN         50     51
FT   STRAND       52     52
FT   STRAND       54     54
FT   STRAND       56     59
FT   TURN         60     61
FT   STRAND       62     66
FT   HELIX        67     77
FT   TURN         78     79
FT   STRAND       81     81
FT   STRAND       83     84
FT   HELIX        85    103
FT   TURN        104    105
FT   STRAND      106    107
FT   HELIX       108    110
FT   STRAND      111    111
FT   HELIX       113    129
FT   TURN        130    130
FT   HELIX       131    142
FT   STRAND      145    148
FT   TURN        149    150
FT   STRAND      151    151
FT   HELIX       154    169
FT   TURN        171    176
FT   HELIX       178    189
FT   STRAND      190    190
FT   HELIX       191    197
FT   STRAND      198    198
FT   TURN        199    200
FT   STRAND      201    202
FT   HELIX       209    219
FT   STRAND      220    220
FT   STRAND      223    224
SQ   SEQUENCE   228 AA;  26195 MW;  C7450E146F41E787 CRC64;
     AAKPVLYYFN GRGKMESIRW LLAAAGVEFE EVFLETREQY EKLLQSGILM FQQVPMVEID
     GMKLVQTRAI LNYIAGKYNL YGKDLKERAL IDMYVGGTDD LMGFLLSFPF LSAEDKVKQC
     AFVVEKATSR YFPAYEKVLK DHGQDFLVGN RLSWADIHLL EAILMVEEKK SDALSGFPLL
     QAFKKRISSI PTIKKFLAPG SKRKPISDDK YVETVRRVLR MYYDVKPH
//