ID   FPIF_BOMMO     STANDARD;      PRT;    77 AA.
AC   Q10731;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   07-FEB-2006, entry version 36.
DE   Fungal protease inhibitor F precursor (FPI-F).
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96424990; PubMed=8827441;
RA   Pham T.-N., Hayashi K., Takano R., Nakazawa H., Mori H., Ichida M.,
RA   Itoh M., Eguchi M., Matsubara F., Hara S.;
RT   "Expression of Bombyx family fungal protease inhibitor F from Bombyx
RT   mori by baculovirus vector.";
RL   J. Biochem. 119:1080-1085(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C124; TISSUE=Fat body;
RA   Itoh M., Takenaka T., Ashikari T., Eguchi M.;
RT   "cDNA cloning and expression of a novel type protease inhibitor
RT   (FPI-F) from the silkworm, Bombyx mori.";
RL   Nihon Sanshigaku Zasshi 65:326-333(1996).
RN   [3]
RP   PROTEIN SEQUENCE OF 23-77.
RX   PubMed=7961602;
RA   Eguchi M., Itoh M., Nishino K., Shibata H., Tanaka T.,
RA   Kamei-Hayashi K., Hara S.;
RT   "Amino acid sequence of an inhibitor from the silkworm (Bombyx mori)
RT   hemolymph against fungal protease.";
RL   J. Biochem. 115:881-884(1994).
RN   [4]
RP   DISULFIDE BONDS.
RX   MEDLINE=96271002; PubMed=8830035;
RA   Pham T.-N., Hayashi K., Takano R., Itoh M., Eguchi M., Shibata H.,
RA   Tanaka T., Hara S.;
RT   "A new family of serine protease inhibitors (Bombyx family) as
RT   established from the unique topological relation between the positions
RT   of disulphide bridges and reactive site.";
RL   J. Biochem. 119:428-434(1996).
CC   -!- FUNCTION: Highly specific for fungal protease and subtilisin.
CC   -!- SUBCELLULAR LOCATION: Secreted protein.
CC   -!- TISSUE SPECIFICITY: Hemolymph.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I40 family.
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DR   EMBL; S83181; AAB46908.1; -; mRNA.
DR   EMBL; D38075; BAA22409.1; -; mRNA.
DR   PIR; JC4790; JC4790.
DR   InterPro; IPR002919; Prot_Inh_CR_TIL.
KW   Direct protein sequencing; Protease inhibitor;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL        1     22       Potential.
FT   CHAIN        23     77       Fungal protease inhibitor F.
FT                                /FTId=PRO_0000026724.
FT   SITE         51     52       Reactive bond.
FT   DISULFID     25     57
FT   DISULFID     36     49
FT   DISULFID     40     77
FT   DISULFID     59     71
SQ   SEQUENCE   77 AA;  8492 MW;  B9CFC085DDA10354 CRC64;
     MASKNLFVLF FIFALFAANI AALQCPKNSE VRNSPCPRTC NDPYGQNSCI TVIRETCHCK
     GELVFDSDSI CVPISQC
//