ID   ITP_SCHGR      STANDARD;      PRT;   130 AA.
AC   Q26491;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   07-FEB-2006, entry version 31.
DE   Ion transport peptide precursor (ITP).
OS   Schistocerca gregaria (Desert locust).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Orthopteroidea; Orthoptera; Caelifera; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96237431; PubMed=8786332;
RA   Meredith J., Ring M., Macins A., Marschall J., Cheng N.N.,
RA   Theilmann D., Brock H.W., Phillips J.E.;
RT   "Locust ion transport peptide (ITP): primary structure, cDNA and
RT   expression in a baculovirus system.";
RL   J. Exp. Biol. 199:1053-1061(1996).
CC   -!- FUNCTION: Stimulates salt and water reabsorption and inhibits acid
CC       secretion in the ileum of S.gregaria.
CC   -!- SUBCELLULAR LOCATION: Secreted protein.
CC   -!- TISSUE SPECIFICITY: Brain and corpus cardiacum.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; U36919; AAB16822.1; -; mRNA.
DR   HSSP; P55847; 1J0T.
DR   InterPro; IPR001166; CHH_MIH_GIH.
DR   InterPro; IPR000346; Hyprgly_hormne1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Signal.
FT   PROPEP        ?     55
FT                                /FTId=PRO_0000019086.
FT   SIGNAL        1      ?       Potential.
FT   PEPTIDE      56    127       Ion transport peptide.
FT                                /FTId=PRO_0000019087.
FT   MOD_RES     127    127       Leucine amide (G-128 provides amide
FT                                group) (Potential).
FT   DISULFID     62     98       By similarity.
FT   DISULFID     78     94       By similarity.
FT   DISULFID     81    107       By similarity.
SQ   SEQUENCE   130 AA;  15022 MW;  9499D8C1B0A93896 CRC64;
     MHHQKQQQQQ KQQGEAPCRH LQWRLSGVVL CVLVVASLVS TAASSPLDPH HLAKRSFFDI
     QCKGVYDKSI FARLDRICED CYNLFREPQL HSLCRSDCFK SPYFKGCLQA LLLIDEEEKF
     NQMVEILGKK
//