ID   GMHA_BURPS     STANDARD;      PRT;   197 AA.
AC   Q93UJ2; Q63R78;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   07-MAR-2006, entry version 24.
DE   Phosphoheptose isomerase (EC 5.3.1.-) (Sedoheptulose 7-phosphate
DE   isomerase).
GN   Name=gmhA; OrderedLocusNames=BPSL2795;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20569162; PubMed=11119486; DOI=10.1128/IAI.69.1.34-44.2001;
RA   Reckseidler S.L., DeShazer D., Sokol P.A., Woods D.E.;
RT   "Detection of bacterial virulence genes by subtractive hybridization:
RT   identification of capsular polysaccharide of Burkholderia pseudomallei
RT   as a major virulence determinant.";
RL   Infect. Immun. 69:34-44(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L.,
RA   Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R.,
RA   Brooks K., Brown K.A., Brown N.F., Challis G.L., Cherevach I.,
RA   Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D.,
RA   Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K.,
RA   Keith K.E., Maddison M., Moule S., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA   Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis,
RT   Burkholderia pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
RN   [3]
RP   BIOSYNTHESIS OF NUCLEOTIDE-ACTIVATED GLYCERO-MANNO-HEPTOSE.
RX   MEDLINE=22095940; PubMed=12101286;
RA   Valvano M.A., Messner P., Kosma P.;
RT   "Novel pathways for biosynthesis of nucleotide-activated glycero-
RT   manno-heptose precursors of bacterial glycoproteins and cell surface
RT   polysaccharides.";
RL   Microbiology 148:1979-1989(2002).
CC   -!- FUNCTION: Catalyzes the isomerization of sedoheptulose 7-phosphate
CC       in D-glycero-D-manno-heptose 7-phosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: D-sedoheptulose 7-phosphate = D-glycero-alpha-
CC       D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose
CC       7-phosphate.
CC   -!- PATHWAY: Capsular polysaccharide (CPS) biosynthesis; GDP-D-
CC       glycero-alpha-D-manno-heptose biosynthesis; first step.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SIS family. GmhA subfamily.
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DR   EMBL; AF228583; AAK49808.1; -; Genomic_DNA.
DR   EMBL; BX571965; CAH36804.1; -; Genomic_DNA.
DR   GenomeReviews; BX571965_GR; BPSL2795.
DR   HAMAP; MF_00067; -; 1.
DR   InterPro; IPR004515; GmhA.
DR   TIGRFAMs; TIGR00441; gmhA; 1.
KW   Bacterial capsule; Carbohydrate metabolism; Complete proteome;
KW   Isomerase.
FT   CHAIN         1    197       Phosphoheptose isomerase.
FT                                /FTId=PRO_0000136521.
FT   CONFLICT     34     34       R -> Q (in Ref. 1).
FT   CONFLICT    115    115       E -> K (in Ref. 1).
SQ   SEQUENCE   197 AA;  20813 MW;  22A249C834AC585B CRC64;
     MENRELTYIT NSIAEAQRVM AAMLADERLL ATVRKVADAC IASIAQGGKV LLAGNGGSAA
     DAQHIAGEFV SRFAFDRPGL PAVALTTDTS ILTAIGNDYG YEKLFSRQVQ ALGNEGDVLI
     GYSTSGKSPN ILAAFREAKA KGMTCVGFTG NRGGEMRELC DLLLEVPSAD TPKIQEGHLV
     LGHIVCGLVE HSIFGKQ
//